CCT5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1formation of translation preinitiation complex (GO:0001731)4.88631430
2DNA unwinding involved in DNA replication (GO:0006268)4.82297501
3DNA strand elongation involved in DNA replication (GO:0006271)4.72687111
4nucleobase biosynthetic process (GO:0046112)4.65962709
5DNA strand elongation (GO:0022616)4.48728165
6sister chromatid segregation (GO:0000819)4.46300448
7pore complex assembly (GO:0046931)4.45927118
8ribosomal small subunit assembly (GO:0000028)4.44013262
9DNA replication initiation (GO:0006270)4.43545982
10maturation of SSU-rRNA (GO:0030490)4.37268201
11purine nucleobase biosynthetic process (GO:0009113)4.36840678
12regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.36513131
13IMP biosynthetic process (GO:0006188)4.34710919
14telomere maintenance via semi-conservative replication (GO:0032201)4.23920043
15protein localization to kinetochore (GO:0034501)4.04695269
16DNA replication-dependent nucleosome organization (GO:0034723)4.02445340
17DNA replication-dependent nucleosome assembly (GO:0006335)4.02445340
18mitotic metaphase plate congression (GO:0007080)3.98100001
19mitotic nuclear envelope disassembly (GO:0007077)3.96175644
20folic acid-containing compound biosynthetic process (GO:0009396)3.95652347
21mitotic sister chromatid cohesion (GO:0007064)3.95493934
22nuclear pore organization (GO:0006999)3.94689089
23ribosomal large subunit biogenesis (GO:0042273)3.86580875
24ribosome biogenesis (GO:0042254)3.84820838
25telomere maintenance via recombination (GO:0000722)3.84244868
26IMP metabolic process (GO:0046040)3.80481592
27ribosome assembly (GO:0042255)3.80139740
28DNA replication checkpoint (GO:0000076)3.78208249
29mitotic recombination (GO:0006312)3.72907129
30regulation of translational fidelity (GO:0006450)3.71996258
31ribonucleoprotein complex biogenesis (GO:0022613)3.69949026
32establishment of viral latency (GO:0019043)3.68664333
33double-strand break repair via nonhomologous end joining (GO:0006303)3.68347357
34non-recombinational repair (GO:0000726)3.68347357
35CENP-A containing nucleosome assembly (GO:0034080)3.68173322
36chromatin remodeling at centromere (GO:0031055)3.67168914
37nuclear envelope disassembly (GO:0051081)3.67155655
38membrane disassembly (GO:0030397)3.67155655
39viral transcription (GO:0019083)3.65906379
40translational termination (GO:0006415)3.64895927
41nuclear pore complex assembly (GO:0051292)3.61416245
42translational initiation (GO:0006413)3.54662770
43telomere maintenance via telomere lengthening (GO:0010833)3.53320218
44metaphase plate congression (GO:0051310)3.52868554
45regulation of mitotic spindle organization (GO:0060236)3.52504542
46spindle checkpoint (GO:0031577)3.51433981
47translational elongation (GO:0006414)3.50157740
48negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.49719107
49regulation of chromosome segregation (GO:0051983)3.46055515
50anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.45431784
51spliceosomal snRNP assembly (GO:0000387)3.44966444
52nucleotide-excision repair, DNA gap filling (GO:0006297)3.44455792
53DNA ligation (GO:0006266)3.44231155
54DNA replication-independent nucleosome organization (GO:0034724)3.42630187
55DNA replication-independent nucleosome assembly (GO:0006336)3.42630187
56mitotic spindle checkpoint (GO:0071174)3.41441879
57regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.41138518
58protein complex localization (GO:0031503)3.41026493
59positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.40137511
60nucleobase-containing small molecule interconversion (GO:0015949)3.39437881
61protein localization to chromosome, centromeric region (GO:0071459)3.38505475
62regulation of centriole replication (GO:0046599)3.37037017
63rRNA processing (GO:0006364)3.36895583
64ribosomal small subunit biogenesis (GO:0042274)3.35850825
65negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.34533466
66proteasome assembly (GO:0043248)3.34039340
67mitotic chromosome condensation (GO:0007076)3.28448866
68establishment of integrated proviral latency (GO:0075713)3.27064187
69rRNA metabolic process (GO:0016072)3.25790339
70cullin deneddylation (GO:0010388)3.23894309
71nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.23342428
72negative regulation of ligase activity (GO:0051352)3.22206133
73negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.22206133
74kinetochore organization (GO:0051383)3.21885535
75regulation of spindle organization (GO:0090224)3.21666153
76establishment of chromosome localization (GO:0051303)3.20481065
77DNA duplex unwinding (GO:0032508)3.18729563
78positive regulation of chromosome segregation (GO:0051984)3.18729418
79regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.17887748
80regulation of mitotic metaphase/anaphase transition (GO:0030071)3.17887748
81SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.17418356
82DNA geometric change (GO:0032392)3.16931789
83maturation of 5.8S rRNA (GO:0000460)3.16263202
84histone exchange (GO:0043486)3.16150713
85attachment of spindle microtubules to kinetochore (GO:0008608)3.15422948
86mitotic sister chromatid segregation (GO:0000070)3.14677478
87transcription-coupled nucleotide-excision repair (GO:0006283)3.14070944
88cellular protein complex localization (GO:0034629)3.13819991
89chromosome segregation (GO:0007059)3.13481418
90somatic hypermutation of immunoglobulin genes (GO:0016446)3.12581426
91somatic diversification of immune receptors via somatic mutation (GO:0002566)3.12581426
92G1/S transition of mitotic cell cycle (GO:0000082)3.11404671
93cell cycle G1/S phase transition (GO:0044843)3.11404671
94DNA topological change (GO:0006265)3.10949321
95regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.10034307
96tRNA aminoacylation for protein translation (GO:0006418)3.09932274
97cotranslational protein targeting to membrane (GO:0006613)3.08774495
98protein targeting to ER (GO:0045047)3.07172651
99DNA synthesis involved in DNA repair (GO:0000731)3.06512230
100regulation of mitotic sister chromatid segregation (GO:0033047)3.06103179
101regulation of sister chromatid segregation (GO:0033045)3.06103179
102regulation of mitotic sister chromatid separation (GO:0010965)3.06103179
103regulation of centrosome cycle (GO:0046605)3.06001260
104regulation of mitochondrial translation (GO:0070129)3.04994997
105protein deneddylation (GO:0000338)3.03802639
106negative regulation of sister chromatid segregation (GO:0033046)3.03152845
107negative regulation of mitotic sister chromatid separation (GO:2000816)3.03152845
108negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03152845
109negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03152845
110negative regulation of chromosome segregation (GO:0051985)3.02885662
111tRNA aminoacylation (GO:0043039)3.02836401
112amino acid activation (GO:0043038)3.02836401
113DNA deamination (GO:0045006)3.00983731
114DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.00346800
115nuclear envelope organization (GO:0006998)3.00283950
116positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.00152924
117viral mRNA export from host cell nucleus (GO:0046784)3.00036343
118pseudouridine synthesis (GO:0001522)2.98027303
119mitotic spindle assembly checkpoint (GO:0007094)2.98026635
120cellular protein complex disassembly (GO:0043624)2.97500229
121spindle assembly checkpoint (GO:0071173)2.97418618
122signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.97376041
123intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.97376041
124spliceosomal complex assembly (GO:0000245)2.96760442
125signal transduction involved in DNA damage checkpoint (GO:0072422)2.95466957
126signal transduction involved in DNA integrity checkpoint (GO:0072401)2.95466957
127regulation of translational termination (GO:0006449)2.95302473
128RNA splicing, via transesterification reactions (GO:0000375)2.95135549
129signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.95035711
130signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.95035711
131signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.95035711
132chromosome condensation (GO:0030261)2.94570964
133meiotic chromosome segregation (GO:0045132)2.91714738

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.26668521
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.60047374
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.90326797
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.64650718
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.57224976
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.29007792
7* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.15272933
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.14549557
9GABP_17652178_ChIP-ChIP_JURKAT_Human3.01388657
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.99435008
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.98514521
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.93989135
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.91134866
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90355844
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.75956641
16* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.57100356
17* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.56443280
18XRN2_22483619_ChIP-Seq_HELA_Human2.48678745
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40196275
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.31487581
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.30177866
22VDR_23849224_ChIP-Seq_CD4+_Human2.26232139
23AR_21909140_ChIP-Seq_LNCAP_Human2.17360027
24* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.13163892
25DCP1A_22483619_ChIP-Seq_HELA_Human2.08481086
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.02971986
27* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.01652472
28* FOXP3_21729870_ChIP-Seq_TREG_Human1.99700123
29GABP_19822575_ChIP-Seq_HepG2_Human1.95322091
30TTF2_22483619_ChIP-Seq_HELA_Human1.94193704
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.93565130
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92891902
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92595864
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.91277976
35* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.90701595
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.89734831
37* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.83301939
38YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77299650
39EGR1_19374776_ChIP-ChIP_THP-1_Human1.77282000
40* ELK1_19687146_ChIP-ChIP_HELA_Human1.73180665
41NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70436058
42* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.69797799
43RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66949409
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63835662
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.61037233
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.60737501
47CIITA_25753668_ChIP-Seq_RAJI_Human1.59620794
48PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.59543675
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.56711060
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56512542
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.53819233
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.53375033
53ZNF263_19887448_ChIP-Seq_K562_Human1.53196776
54KDM5A_27292631_Chip-Seq_BREAST_Human1.49766739
55HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46481669
56* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45390643
57* SRF_21415370_ChIP-Seq_HL-1_Mouse1.41973030
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.41561487
59MYC_22102868_ChIP-Seq_BL_Human1.39298083
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34506525
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.32101574
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31662855
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28146569
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26468795
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26328487
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.24672298
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22056262
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18730131
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18127306
70TFEB_21752829_ChIP-Seq_HELA_Human1.17981337
71KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17881680
72SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16877421
73MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.16694272
74SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.15915300
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15516722
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13252242
77FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11948501
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.10861352
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06963359
80CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06314454
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02701778
82BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01207510
83* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00914638
84HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00626485
85* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98942812
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97971447
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96905782
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96343840
89ELK1_22589737_ChIP-Seq_MCF10A_Human0.95839337
90HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94379008
91TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.93671952
92* MYC_18940864_ChIP-ChIP_HL60_Human0.93283358
93CHD1_26751641_Chip-Seq_LNCaP_Human0.91674398
94ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91376040
95CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89244443
96* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88891575
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88193501
98TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87878075
99SALL1_21062744_ChIP-ChIP_HESCs_Human0.87534579
100NANOG_21062744_ChIP-ChIP_HESCs_Human0.87246099
101NANOG_16153702_ChIP-ChIP_HESCs_Human0.84459136
102NOTCH1_21737748_ChIP-Seq_TLL_Human0.84147325
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84077140
104SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.83331835
105OCT4_18692474_ChIP-Seq_MEFs_Mouse0.81218263
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.81138361
107TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80774296
108NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.80579300
109ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.79236747
110SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79184661
111SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.77467325
112EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.75721649
113CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.75535834
114TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.74857620

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.40257048
2MP0010094_abnormal_chromosome_stability4.74720908
3MP0004957_abnormal_blastocyst_morpholog4.70185792
4MP0003111_abnormal_nucleus_morphology4.37295302
5MP0003077_abnormal_cell_cycle4.08704884
6MP0008057_abnormal_DNA_replication3.67244081
7MP0008058_abnormal_DNA_repair3.59151221
8MP0008007_abnormal_cellular_replicative3.08652441
9MP0003123_paternal_imprinting2.95447303
10MP0008932_abnormal_embryonic_tissue2.88859021
11MP0001730_embryonic_growth_arrest2.63831807
12MP0010352_gastrointestinal_tract_polyps2.46347270
13MP0008877_abnormal_DNA_methylation2.39542035
14MP0002877_abnormal_melanocyte_morpholog2.38126561
15MP0000350_abnormal_cell_proliferation2.33252836
16MP0002396_abnormal_hematopoietic_system2.09755149
17MP0003786_premature_aging2.01141640
18MP0001697_abnormal_embryo_size1.88634832
19MP0005380_embryogenesis_phenotype1.85475100
20MP0001672_abnormal_embryogenesis/_devel1.85475100
21MP0010307_abnormal_tumor_latency1.81395016
22MP0010030_abnormal_orbit_morphology1.81116778
23MP0003806_abnormal_nucleotide_metabolis1.78841351
24MP0002080_prenatal_lethality1.75136544
25MP0003984_embryonic_growth_retardation1.69170501
26MP0002088_abnormal_embryonic_growth/wei1.64854833
27MP0004197_abnormal_fetal_growth/weight/1.63338620
28MP0002085_abnormal_embryonic_tissue1.63034659
29MP0003121_genomic_imprinting1.62544791
30MP0002084_abnormal_developmental_patter1.59826633
31MP0000537_abnormal_urethra_morphology1.55937471
32MP0010234_abnormal_vibrissa_follicle1.50145028
33MP0000490_abnormal_crypts_of1.50111307
34MP0003718_maternal_effect1.46344028
35MP0000313_abnormal_cell_death1.45328751
36MP0002086_abnormal_extraembryonic_tissu1.42679872
37MP0003567_abnormal_fetal_cardiomyocyte1.42439737
38MP0001661_extended_life_span1.42273326
39MP0003890_abnormal_embryonic-extraembry1.40485026
40MP0004808_abnormal_hematopoietic_stem1.38442992
41MP0001293_anophthalmia1.36619895
42MP0002019_abnormal_tumor_incidence1.33950616
43MP0009053_abnormal_anal_canal1.31773295
44MP0003315_abnormal_perineum_morphology1.23644674
45MP0003119_abnormal_digestive_system1.20887562
46MP0005408_hypopigmentation1.18561425
47MP0002210_abnormal_sex_determination1.18401700
48MP0000358_abnormal_cell_content/1.14777234
49MP0006054_spinal_hemorrhage1.14128871
50MP0004133_heterotaxia1.13215340
51MP0000372_irregular_coat_pigmentation1.12181764
52MP0005501_abnormal_skin_physiology1.09742770
53MP0001145_abnormal_male_reproductive1.06296978
54MP0002160_abnormal_reproductive_system1.03483505
55MP0005623_abnormal_meninges_morphology1.03020803
56MP0009333_abnormal_splenocyte_physiolog0.99636799
57MP0005076_abnormal_cell_differentiation0.99219281
58MP0009672_abnormal_birth_weight0.97056803
59MP0002111_abnormal_tail_morphology0.94298798
60MP0004185_abnormal_adipocyte_glucose0.93431342
61MP0002796_impaired_skin_barrier0.93150432
62MP0002938_white_spotting0.91630125
63MP0001929_abnormal_gametogenesis0.91302569
64MP0000579_abnormal_nail_morphology0.89421743
65MP0005023_abnormal_wound_healing0.87892467
66MP0000653_abnormal_sex_gland0.87867941
67MP0000703_abnormal_thymus_morphology0.87521351
68MP0005384_cellular_phenotype0.86498019
69MP0003763_abnormal_thymus_physiology0.84448177
70MP0003221_abnormal_cardiomyocyte_apopto0.83356623
71MP0005389_reproductive_system_phenotype0.82674302
72MP0003186_abnormal_redox_activity0.81599191
73MP0002653_abnormal_ependyma_morphology0.81215957
74MP0003937_abnormal_limbs/digits/tail_de0.78014415
75MP0000647_abnormal_sebaceous_gland0.77862907
76MP0003705_abnormal_hypodermis_morpholog0.77431700
77MP0000858_altered_metastatic_potential0.77276754
78MP0002060_abnormal_skin_morphology0.77199919
79MP0003566_abnormal_cell_adhesion0.77170255
80MP0000428_abnormal_craniofacial_morphol0.75171737
81MP0006292_abnormal_olfactory_placode0.73442325
82MP0005621_abnormal_cell_physiology0.73310708
83MP0001286_abnormal_eye_development0.72549143
84MP0009703_decreased_birth_body0.72283867
85MP0001545_abnormal_hematopoietic_system0.72229239
86MP0005397_hematopoietic_system_phenotyp0.72229239
87MP0003115_abnormal_respiratory_system0.71465189
88MP0001119_abnormal_female_reproductive0.70842083
89MP0001727_abnormal_embryo_implantation0.70680773
90MP0002722_abnormal_immune_system0.70618463
91MP0003385_abnormal_body_wall0.69643254
92MP0003950_abnormal_plasma_membrane0.69461951
93MP0001915_intracranial_hemorrhage0.68898888
94MP0005171_absent_coat_pigmentation0.68828369
95MP0003941_abnormal_skin_development0.68036910
96MP0002092_abnormal_eye_morphology0.67553370
97MP0002398_abnormal_bone_marrow0.67310332
98MP0003942_abnormal_urinary_system0.65421131
99MP0001188_hyperpigmentation0.63098069
100MP0000689_abnormal_spleen_morphology0.63028582
101MP0002132_abnormal_respiratory_system0.62930080
102MP0006035_abnormal_mitochondrial_morpho0.62910227
103MP0003699_abnormal_female_reproductive0.62448911
104MP0004233_abnormal_muscle_weight0.62187264
105MP0000762_abnormal_tongue_morphology0.62139793
106MP0003943_abnormal_hepatobiliary_system0.61772834
107MP0002697_abnormal_eye_size0.61132266
108MP0000477_abnormal_intestine_morphology0.61017063
109MP0006036_abnormal_mitochondrial_physio0.59970737
110MP0001849_ear_inflammation0.59894901
111MP0005395_other_phenotype0.59828119
112MP0000627_abnormal_mammary_gland0.59276631
113MP0005266_abnormal_metabolism0.59261785
114MP0002233_abnormal_nose_morphology0.58960284
115MP0008260_abnormal_autophagy0.58935392
116MP0002751_abnormal_autonomic_nervous0.58724742
117MP0002161_abnormal_fertility/fecundity0.58130504
118MP0002282_abnormal_trachea_morphology0.57940901
119MP0002009_preneoplasia0.56224761
120MP0001186_pigmentation_phenotype0.55214667
121MP0001881_abnormal_mammary_gland0.54940320
122MP0001919_abnormal_reproductive_system0.54930867
123MP0002429_abnormal_blood_cell0.54786220
124MP0001216_abnormal_epidermal_layer0.54519679
125MP0003122_maternal_imprinting0.53360054
126MP0001243_abnormal_dermal_layer0.53051854
127MP0009697_abnormal_copulation0.52386624
128MP0005187_abnormal_penis_morphology0.51976966
129MP0000049_abnormal_middle_ear0.49921711
130MP0002269_muscular_atrophy0.49364603
131MP0002114_abnormal_axial_skeleton0.48273546

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.81322085
2Colon cancer (HP:0003003)4.11393859
3Reticulocytopenia (HP:0001896)4.02684087
4Abnormality of cells of the erythroid lineage (HP:0012130)3.83029297
5Selective tooth agenesis (HP:0001592)3.73972522
6Degeneration of anterior horn cells (HP:0002398)3.63211909
7Abnormality of the anterior horn cell (HP:0006802)3.63211909
8Abnormal number of erythroid precursors (HP:0012131)3.58844709
9Breast hypoplasia (HP:0003187)3.56576049
10Oral leukoplakia (HP:0002745)3.53241845
11Ependymoma (HP:0002888)3.36145700
12Microvesicular hepatic steatosis (HP:0001414)3.19621846
13Medulloblastoma (HP:0002885)3.19294988
14Patellar aplasia (HP:0006443)3.10178535
1511 pairs of ribs (HP:0000878)3.04184554
16Carpal bone hypoplasia (HP:0001498)3.03862816
17Cerebral hypomyelination (HP:0006808)3.03725376
18Aplasia/Hypoplasia of the patella (HP:0006498)2.89270452
19Agnosia (HP:0010524)2.88138292
20Chromsome breakage (HP:0040012)2.86838306
21Rough bone trabeculation (HP:0100670)2.86272443
22Aplastic anemia (HP:0001915)2.84623356
23Trismus (HP:0000211)2.77436952
24Abnormality of methionine metabolism (HP:0010901)2.68691714
25Macrocytic anemia (HP:0001972)2.67404734
26Volvulus (HP:0002580)2.65424807
27Cortical dysplasia (HP:0002539)2.63290288
28Nephroblastoma (Wilms tumor) (HP:0002667)2.62865239
29Meckel diverticulum (HP:0002245)2.62849666
30Absent thumb (HP:0009777)2.62474602
31Neoplasm of the pancreas (HP:0002894)2.61699750
32Abnormality of chromosome stability (HP:0003220)2.60774263
33Abnormality of the labia minora (HP:0012880)2.59354320
34Abnormality of the preputium (HP:0100587)2.58493762
35Progressive muscle weakness (HP:0003323)2.56526725
36Missing ribs (HP:0000921)2.54448752
37Abnormal lung lobation (HP:0002101)2.54294946
38Chromosomal breakage induced by crosslinking agents (HP:0003221)2.52168862
39Abnormality of the ileum (HP:0001549)2.49788578
40Rhabdomyosarcoma (HP:0002859)2.48834608
41Multiple enchondromatosis (HP:0005701)2.47739196
42Abnormal number of incisors (HP:0011064)2.47157034
43Premature graying of hair (HP:0002216)2.46801298
44Pallor (HP:0000980)2.39509889
45Abnormality of glycolysis (HP:0004366)2.36899227
46Increased serum pyruvate (HP:0003542)2.36899227
47Microretrognathia (HP:0000308)2.35252934
48Absent radius (HP:0003974)2.34344490
49Small intestinal stenosis (HP:0012848)2.34088279
50Duodenal stenosis (HP:0100867)2.34088279
51Myelodysplasia (HP:0002863)2.33823139
52Abnormality of the umbilical cord (HP:0010881)2.31354009
53Deviation of the thumb (HP:0009603)2.31240570
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.30699144
55Proximal placement of thumb (HP:0009623)2.28657163
56Glossoptosis (HP:0000162)2.28309185
57Abnormality of the carotid arteries (HP:0005344)2.26353319
58Horseshoe kidney (HP:0000085)2.24009507
59Atrophy/Degeneration involving motor neurons (HP:0007373)2.23796703
60Basal cell carcinoma (HP:0002671)2.20560333
61Atresia of the external auditory canal (HP:0000413)2.18435053
62Progressive external ophthalmoplegia (HP:0000590)2.17893612
63Impulsivity (HP:0100710)2.16236741
64Absent forearm bone (HP:0003953)2.16059497
65Aplasia involving forearm bones (HP:0009822)2.16059497
66Abnormality of the calcaneus (HP:0008364)2.15103366
67Thrombocytosis (HP:0001894)2.14521937
68Cellular immunodeficiency (HP:0005374)2.13118766
69Increased nuchal translucency (HP:0010880)2.12657084
70Facial cleft (HP:0002006)2.12254966
71Sloping forehead (HP:0000340)2.11755515
72Neoplasm of the colon (HP:0100273)2.11060337
73Abnormality of the astrocytes (HP:0100707)2.09620565
74Astrocytoma (HP:0009592)2.09620565
75Bone marrow hypocellularity (HP:0005528)2.09241921
76Spastic diplegia (HP:0001264)2.09241591
77Choanal atresia (HP:0000453)2.08977890
78Slender long bone (HP:0003100)2.08617985
79Abnormalities of placenta or umbilical cord (HP:0001194)2.06502912
80Aplasia/Hypoplasia of the sternum (HP:0006714)2.06331278
81Supernumerary spleens (HP:0009799)2.05258185
82Cerebral edema (HP:0002181)2.04497639
83Abnormal trabecular bone morphology (HP:0100671)2.03771632
84Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.02653335
85Glioma (HP:0009733)2.02524728
86Cafe-au-lait spot (HP:0000957)2.01925864
87Abnormality of the fetal cardiovascular system (HP:0010948)2.01859978
88Abnormal umbilical cord blood vessels (HP:0011403)2.01859978
89Single umbilical artery (HP:0001195)2.01859978
90Hypoplasia of the capital femoral epiphysis (HP:0003090)2.01801292
91Abnormality of alanine metabolism (HP:0010916)2.01411212
92Hyperalaninemia (HP:0003348)2.01411212
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01411212
94Ragged-red muscle fibers (HP:0003200)1.99099670
95Abnormality of the duodenum (HP:0002246)1.99042566
96Tracheoesophageal fistula (HP:0002575)1.99011589
97Aplasia/Hypoplasia of the sacrum (HP:0008517)1.98337677
98Abnormal mitochondria in muscle tissue (HP:0008316)1.97743295
99Squamous cell carcinoma (HP:0002860)1.97714820
100Amaurosis fugax (HP:0100576)1.95462777
101Increased hepatocellular lipid droplets (HP:0006565)1.94650502
102Premature ovarian failure (HP:0008209)1.94479005
103Type I transferrin isoform profile (HP:0003642)1.94431084
104Secondary amenorrhea (HP:0000869)1.93227701
105Ovarian neoplasm (HP:0100615)1.92162770
106Overlapping toe (HP:0001845)1.91471394
107CNS hypomyelination (HP:0003429)1.91221467
108Sparse eyelashes (HP:0000653)1.89687054
109Optic nerve coloboma (HP:0000588)1.88677226
110Biliary tract neoplasm (HP:0100574)1.87971345
111Cutaneous melanoma (HP:0012056)1.87855830
112Increased CSF lactate (HP:0002490)1.87572612
113Ectopic kidney (HP:0000086)1.87296943
114Reduced antithrombin III activity (HP:0001976)1.86258928
115Acute encephalopathy (HP:0006846)1.84845778
116Deep philtrum (HP:0002002)1.82633169
117Adenoma sebaceum (HP:0009720)1.81973827
118Angiofibromas (HP:0010615)1.81973827
119Prominent metopic ridge (HP:0005487)1.81964484
120Triphalangeal thumb (HP:0001199)1.81049795
121Cleft eyelid (HP:0000625)1.79804965
122Abnormal gallbladder physiology (HP:0012438)1.79538013
123Cholecystitis (HP:0001082)1.79538013
124Shoulder girdle muscle weakness (HP:0003547)1.77219203
125Decreased activity of mitochondrial respiratory chain (HP:0008972)1.77099169
126Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.77099169
127Acute necrotizing encephalopathy (HP:0006965)1.76203611
128Hypoplasia of the pons (HP:0012110)1.76180999
129Postnatal microcephaly (HP:0005484)1.75563756
130Increased serum lactate (HP:0002151)1.73667578
131Megaloblastic anemia (HP:0001889)1.73335704
132Freckling (HP:0001480)1.72960950
133Pelvic girdle muscle weakness (HP:0003749)1.72944866
134Embryonal renal neoplasm (HP:0011794)1.72513332
135Neoplasm of striated muscle (HP:0009728)1.72052157
136Abnormality of serum amino acid levels (HP:0003112)1.70362526
137Entropion (HP:0000621)1.69914262
138Lipid accumulation in hepatocytes (HP:0006561)1.67630784
139Microglossia (HP:0000171)1.66983384
140Pancytopenia (HP:0001876)1.64791912
141Ankyloglossia (HP:0010296)1.63542445
142Homocystinuria (HP:0002156)1.63087568
143Abnormality of homocysteine metabolism (HP:0010919)1.63087568

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.59315304
2WEE14.07253360
3CDC73.96679746
4EIF2AK13.46143878
5TSSK63.32473875
6PASK2.70756381
7NEK12.58776825
8SRPK12.40943817
9NEK22.32974532
10BRSK22.19217747
11TTK2.17213896
12MST1R2.14038820
13EIF2AK32.12216707
14STK162.06591308
15TESK22.05489022
16MKNK11.97271030
17ACVR1B1.90580710
18PLK11.90037236
19PLK41.87441530
20VRK21.85374896
21RPS6KB21.82158062
22PLK31.79386582
23NME21.75205134
24ATR1.66675572
25AURKB1.65330317
26TGFBR11.63696922
27EEF2K1.59138712
28EPHA21.53953121
29VRK11.51801740
30CDK71.46065272
31TESK11.44579474
32SCYL21.41303892
33BRSK11.39156443
34RPS6KA41.37254021
35TRIM281.31339241
36PAK41.30136617
37TLK11.29805827
38MAP3K81.28044692
39AURKA1.27343550
40CCNB11.26926506
41DYRK31.19325247
42CHEK21.18962388
43CHEK11.17768393
44SMG11.17640887
45PKN21.11449060
46ERBB41.06991396
47MET1.06517760
48MKNK21.06268140
49STK101.06267846
50CDK41.03850525
51ZAK1.00187283
52TAF10.98393071
53CDK120.91746800
54PDK30.90912276
55PDK40.90912276
56FLT30.89193767
57LIMK10.88880769
58IRAK30.85705790
59LRRK20.85487076
60STK40.82145268
61ATM0.80535699
62CDK20.78175594
63CSNK2A20.75767042
64CDK80.74757523
65CLK10.74735609
66PAK10.73628952
67MAP3K120.72334235
68NME10.72192186
69PBK0.71875161
70ALK0.69744355
71ILK0.68984749
72CSNK2A10.67328280
73MAP3K100.65894828
74PIM20.60982270
75LATS10.60040869
76PIM10.58604471
77CDK10.58091226
78MAP2K30.58085347
79KDR0.57835878
80EIF2AK20.57725651
81BRD40.57579900
82STK38L0.57293607
83PRKCI0.57018437
84TAOK20.56232932
85MELK0.54507361
86PNCK0.53900168
87BRAF0.48419698
88ICK0.47578901
89CSNK1G10.46500423
90CSNK1G30.46200164
91MAP3K110.46131788
92BCKDK0.44705235
93FGFR10.44452640
94MAP3K30.43645584
95DAPK10.43064616
96CDK60.42972254
97BCR0.41813576
98RPS6KA50.41540257
99MAPKAPK50.40935064
100RAF10.40929088
101NUAK10.40707265
102MST40.39636530
103MAPKAPK30.38918104
104PDK20.38696695
105PLK20.38172356
106CSNK1E0.37279181
107NEK60.36769210
108STK30.36743114
109PAK20.34572320
110CSNK1A1L0.34060481
111PRKDC0.33614992
112MTOR0.33124432
113CDK180.32383042
114CDK140.30119888
115MAP4K10.29872941
116TTN0.29350518
117DYRK20.29220914
118ZAP700.29020629
119AKT20.28754184
120LATS20.28666496
121CDK150.28534540
122RPS6KB10.27561411
123CDK11A0.27401265
124ERBB30.26702218
125PTK20.26255738
126CDK90.25709632
127NEK90.25316681
128CDK30.22580911
129BTK0.20720341

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.80810709
2Mismatch repair_Homo sapiens_hsa034304.23944693
3Proteasome_Homo sapiens_hsa030503.95828956
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.72137546
5Ribosome_Homo sapiens_hsa030103.41446970
6Spliceosome_Homo sapiens_hsa030403.37555532
7RNA transport_Homo sapiens_hsa030133.31345077
8RNA polymerase_Homo sapiens_hsa030203.20147408
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.09872938
10Base excision repair_Homo sapiens_hsa034102.97342052
11Nucleotide excision repair_Homo sapiens_hsa034202.91496705
12One carbon pool by folate_Homo sapiens_hsa006702.75903224
13Homologous recombination_Homo sapiens_hsa034402.71953554
14Cell cycle_Homo sapiens_hsa041102.63799283
15Pyrimidine metabolism_Homo sapiens_hsa002402.38807890
16Non-homologous end-joining_Homo sapiens_hsa034502.11529293
17Fanconi anemia pathway_Homo sapiens_hsa034601.93220324
18RNA degradation_Homo sapiens_hsa030181.92061587
19Basal transcription factors_Homo sapiens_hsa030221.81850261
20mRNA surveillance pathway_Homo sapiens_hsa030151.80695006
21p53 signaling pathway_Homo sapiens_hsa041151.39659328
22Purine metabolism_Homo sapiens_hsa002301.29651856
23Epstein-Barr virus infection_Homo sapiens_hsa051691.28245268
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.20436043
25Systemic lupus erythematosus_Homo sapiens_hsa053221.16408598
26Biosynthesis of amino acids_Homo sapiens_hsa012301.13259609
27Fatty acid elongation_Homo sapiens_hsa000621.05650256
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.03294082
29Steroid biosynthesis_Homo sapiens_hsa001000.99130910
30Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.98951175
31Protein export_Homo sapiens_hsa030600.98849201
32Viral carcinogenesis_Homo sapiens_hsa052030.97392273
33Antigen processing and presentation_Homo sapiens_hsa046120.96878317
34Propanoate metabolism_Homo sapiens_hsa006400.93949803
35Selenocompound metabolism_Homo sapiens_hsa004500.93864239
36Oocyte meiosis_Homo sapiens_hsa041140.93107681
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.88352339
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88277067
39Pentose phosphate pathway_Homo sapiens_hsa000300.87983621
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85744309
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83567620
42Carbon metabolism_Homo sapiens_hsa012000.81439491
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.79474410
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78741983
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.78012920
46Legionellosis_Homo sapiens_hsa051340.72837376
47Herpes simplex infection_Homo sapiens_hsa051680.71993668
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71957003
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70958199
50Huntingtons disease_Homo sapiens_hsa050160.69658280
51HTLV-I infection_Homo sapiens_hsa051660.69302447
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.68719753
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68521252
54Thyroid cancer_Homo sapiens_hsa052160.60775567
55Parkinsons disease_Homo sapiens_hsa050120.59416959
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57343544
57Folate biosynthesis_Homo sapiens_hsa007900.57268300
58Glutathione metabolism_Homo sapiens_hsa004800.53978717
59N-Glycan biosynthesis_Homo sapiens_hsa005100.52715272
60Arginine biosynthesis_Homo sapiens_hsa002200.50820467
61Alzheimers disease_Homo sapiens_hsa050100.50681784
62Fructose and mannose metabolism_Homo sapiens_hsa000510.48213999
63Small cell lung cancer_Homo sapiens_hsa052220.47378801
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47306074
65Lysine degradation_Homo sapiens_hsa003100.46567889
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46400960
67Vitamin B6 metabolism_Homo sapiens_hsa007500.45714310
68MicroRNAs in cancer_Homo sapiens_hsa052060.45061475
69Hippo signaling pathway_Homo sapiens_hsa043900.44949072
70Alcoholism_Homo sapiens_hsa050340.44370921
71Fatty acid metabolism_Homo sapiens_hsa012120.44328704
72Sulfur metabolism_Homo sapiens_hsa009200.40796816
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37370343
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.37131805
75TGF-beta signaling pathway_Homo sapiens_hsa043500.36797404
76Galactose metabolism_Homo sapiens_hsa000520.36671477
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35369059
78Colorectal cancer_Homo sapiens_hsa052100.35011397
79Pyruvate metabolism_Homo sapiens_hsa006200.33321542
80Apoptosis_Homo sapiens_hsa042100.33261629
81Basal cell carcinoma_Homo sapiens_hsa052170.32962024
82Sulfur relay system_Homo sapiens_hsa041220.32899072
83Shigellosis_Homo sapiens_hsa051310.31107091
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30789559
85Oxidative phosphorylation_Homo sapiens_hsa001900.30082921
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.29949210
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.28548464
88HIF-1 signaling pathway_Homo sapiens_hsa040660.27586462
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27257865
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.26132096
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.25941510
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24822547
93Bladder cancer_Homo sapiens_hsa052190.24644109
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22593784
95Metabolic pathways_Homo sapiens_hsa011000.21665121
96Measles_Homo sapiens_hsa051620.20030147
97Notch signaling pathway_Homo sapiens_hsa043300.19682703
98Hedgehog signaling pathway_Homo sapiens_hsa043400.18475571
99Viral myocarditis_Homo sapiens_hsa054160.18416391
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.18145882
101Hepatitis B_Homo sapiens_hsa051610.18021425
102Vibrio cholerae infection_Homo sapiens_hsa051100.17021290
103Tyrosine metabolism_Homo sapiens_hsa003500.16017839
104Pathways in cancer_Homo sapiens_hsa052000.15316388
105Primary immunodeficiency_Homo sapiens_hsa053400.14942056
106Chronic myeloid leukemia_Homo sapiens_hsa052200.14584860
107Adherens junction_Homo sapiens_hsa045200.13802421
108Tight junction_Homo sapiens_hsa045300.13445778
109Renin-angiotensin system_Homo sapiens_hsa046140.11467239
110Phenylalanine metabolism_Homo sapiens_hsa003600.11387629
111Wnt signaling pathway_Homo sapiens_hsa043100.11275271
112Influenza A_Homo sapiens_hsa051640.11165604
113Pancreatic cancer_Homo sapiens_hsa052120.09782158
114Prostate cancer_Homo sapiens_hsa052150.07977922
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.07636352
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.06874310
117mTOR signaling pathway_Homo sapiens_hsa041500.06050058
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.04097387
119Arginine and proline metabolism_Homo sapiens_hsa003300.02562139
120Melanoma_Homo sapiens_hsa052180.01846750

Most similar genes based on co-expression Upload to Enrichr

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