CCT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.29928793
2nuclear pore organization (GO:0006999)4.76889947
3formation of translation preinitiation complex (GO:0001731)4.61654277
4nuclear pore complex assembly (GO:0051292)4.57321425
5protein localization to kinetochore (GO:0034501)4.49818221
6DNA strand elongation involved in DNA replication (GO:0006271)4.36437643
7folic acid-containing compound biosynthetic process (GO:0009396)4.34972690
8DNA replication initiation (GO:0006270)4.34259191
9maturation of SSU-rRNA (GO:0030490)4.28669874
10mitotic nuclear envelope disassembly (GO:0007077)4.26535415
11DNA replication-dependent nucleosome organization (GO:0034723)4.21427300
12DNA replication-dependent nucleosome assembly (GO:0006335)4.21427300
13IMP biosynthetic process (GO:0006188)4.16613548
14nucleobase biosynthetic process (GO:0046112)4.12133823
15DNA strand elongation (GO:0022616)4.11335222
16nuclear envelope disassembly (GO:0051081)4.00798034
17membrane disassembly (GO:0030397)4.00798034
18ribosomal small subunit assembly (GO:0000028)3.92313683
19ribosome assembly (GO:0042255)3.86608812
20mitotic metaphase plate congression (GO:0007080)3.84861341
21translational termination (GO:0006415)3.84683281
22viral transcription (GO:0019083)3.84270277
23telomere maintenance via semi-conservative replication (GO:0032201)3.77707032
24IMP metabolic process (GO:0046040)3.76733400
25purine nucleobase biosynthetic process (GO:0009113)3.73557360
26protein localization to chromosome, centromeric region (GO:0071459)3.72977114
27translational initiation (GO:0006413)3.64649230
28establishment of viral latency (GO:0019043)3.64627537
29ribosomal large subunit biogenesis (GO:0042273)3.64514878
30DNA replication checkpoint (GO:0000076)3.63406869
31DNA duplex unwinding (GO:0032508)3.60025130
32DNA geometric change (GO:0032392)3.57777896
33translational elongation (GO:0006414)3.57345750
34mitotic chromosome condensation (GO:0007076)3.53087375
35heterochromatin organization (GO:0070828)3.50941808
36synapsis (GO:0007129)3.50113019
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.47021002
38double-strand break repair via nonhomologous end joining (GO:0006303)3.46319198
39non-recombinational repair (GO:0000726)3.46319198
40DNA ligation (GO:0006266)3.45827523
41pore complex assembly (GO:0046931)3.45408348
42metaphase plate congression (GO:0051310)3.43833081
43mitotic recombination (GO:0006312)3.41843786
44regulation of spindle organization (GO:0090224)3.41180782
45regulation of posttranscriptional gene silencing (GO:0060147)3.41071004
46regulation of gene silencing by miRNA (GO:0060964)3.41071004
47regulation of gene silencing by RNA (GO:0060966)3.41071004
48ribosome biogenesis (GO:0042254)3.40841471
49ribonucleoprotein complex biogenesis (GO:0022613)3.39855696
50telomere maintenance via recombination (GO:0000722)3.39326433
51regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.36887372
52proteasome assembly (GO:0043248)3.35712604
53chromatin remodeling at centromere (GO:0031055)3.35563953
54regulation of translational fidelity (GO:0006450)3.35507594
55ribosomal small subunit biogenesis (GO:0042274)3.31427164
56negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.30865442
57CENP-A containing nucleosome assembly (GO:0034080)3.27259909
58DNA replication-independent nucleosome organization (GO:0034724)3.26445106
59DNA replication-independent nucleosome assembly (GO:0006336)3.26445106
60kinetochore organization (GO:0051383)3.25492903
61regulation of centriole replication (GO:0046599)3.24670444
62regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.24470178
63anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.24414274
64regulation of histone H3-K9 methylation (GO:0051570)3.24007640
65mitotic sister chromatid segregation (GO:0000070)3.23463331
66sister chromatid segregation (GO:0000819)3.22650031
67negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.22638993
68attachment of spindle microtubules to kinetochore (GO:0008608)3.19911637
69regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.18617590
70telomere maintenance via telomere lengthening (GO:0010833)3.18162813
71mitotic sister chromatid cohesion (GO:0007064)3.17143130
72positive regulation of chromosome segregation (GO:0051984)3.15533598
73negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.15471264
74regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.14832708
75nuclear envelope organization (GO:0006998)3.12547331
76establishment of chromosome localization (GO:0051303)3.09911905
77DNA synthesis involved in DNA repair (GO:0000731)3.09852266
78SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.09842509
79somatic diversification of immune receptors via somatic mutation (GO:0002566)3.09419782
80somatic hypermutation of immunoglobulin genes (GO:0016446)3.09419782
81cellular protein complex disassembly (GO:0043624)3.09093009
82establishment of integrated proviral latency (GO:0075713)3.08849275
83negative regulation of RNA splicing (GO:0033119)3.08602388
84positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.07902559
85negative regulation of histone methylation (GO:0031061)3.07632181
86nucleotide-excision repair, DNA gap filling (GO:0006297)3.07477658
87rRNA processing (GO:0006364)3.06216358
88negative regulation of ligase activity (GO:0051352)3.05855592
89negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.05855592
90establishment of protein localization to mitochondrial membrane (GO:0090151)3.04388924
91spliceosomal snRNP assembly (GO:0000387)3.03455610
92tRNA aminoacylation for protein translation (GO:0006418)3.03403903
93regulation of translational termination (GO:0006449)3.03275613
94regulation of chromosome segregation (GO:0051983)3.02997906
95regulation of mitochondrial translation (GO:0070129)3.02581550
96DNA topological change (GO:0006265)3.02434749
97protein targeting to ER (GO:0045047)3.01478703
98cotranslational protein targeting to membrane (GO:0006613)3.01383456
99peptidyl-arginine omega-N-methylation (GO:0035247)3.00913987
100pre-miRNA processing (GO:0031054)3.00908348
101negative regulation of chromosome segregation (GO:0051985)3.00753985
102chromatin assembly or disassembly (GO:0006333)3.00715345
103viral life cycle (GO:0019058)3.00343748
104DNA damage response, detection of DNA damage (GO:0042769)2.99482160
105regulation of centrosome cycle (GO:0046605)2.98866293
106amino acid activation (GO:0043038)2.98647520
107tRNA aminoacylation (GO:0043039)2.98647520
108spindle checkpoint (GO:0031577)2.98304274
109negative regulation of mitotic sister chromatid separation (GO:2000816)2.97782617
110negative regulation of mitotic sister chromatid segregation (GO:0033048)2.97782617
111negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.97782617
112negative regulation of sister chromatid segregation (GO:0033046)2.97782617
113regulation of helicase activity (GO:0051095)2.97257346
114rRNA metabolic process (GO:0016072)2.96554484
115spindle assembly checkpoint (GO:0071173)2.96364608
116mitotic spindle assembly checkpoint (GO:0007094)2.95797207
117histone exchange (GO:0043486)2.95353768
118RNA splicing, via transesterification reactions (GO:0000375)2.94800910
119mitotic spindle checkpoint (GO:0071174)2.94644198
120mRNA splicing, via spliceosome (GO:0000398)2.94424450
121RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.94424450
122ATP-dependent chromatin remodeling (GO:0043044)2.94194407
123regulation of mitotic spindle organization (GO:0060236)2.93843066
124regulation of mitotic metaphase/anaphase transition (GO:0030071)2.91898845
125regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.91898845
126regulation of sister chromatid segregation (GO:0033045)2.85819746
127regulation of mitotic sister chromatid separation (GO:0010965)2.85819746
128regulation of mitotic sister chromatid segregation (GO:0033047)2.85819746
129cullin deneddylation (GO:0010388)2.84143680
130DNA catabolic process, exonucleolytic (GO:0000738)2.83004445
131cell cycle G1/S phase transition (GO:0044843)2.79821398
132G1/S transition of mitotic cell cycle (GO:0000082)2.79821398
133mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.77488618

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.96886283
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.45612182
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.24582603
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.73125497
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.71580297
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.24198239
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.03273733
8* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.84445594
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.73344110
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.62838478
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.54531394
12NELFA_20434984_ChIP-Seq_ESCs_Mouse2.49984787
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.43581555
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.38133052
15* XRN2_22483619_ChIP-Seq_HELA_Human2.37858254
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.37131305
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.33888177
18AR_21909140_ChIP-Seq_LNCAP_Human2.32840303
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.32299167
20* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.18745317
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13619413
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13280419
23E2F1_21310950_ChIP-Seq_MCF-7_Human2.10599387
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.09005259
25MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97270244
26VDR_23849224_ChIP-Seq_CD4+_Human1.96192505
27MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96076798
28MYC_22102868_ChIP-Seq_BL_Human1.90670663
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86389252
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86000594
31DCP1A_22483619_ChIP-Seq_HELA_Human1.82814404
32TTF2_22483619_ChIP-Seq_HELA_Human1.81358852
33FOXP3_21729870_ChIP-Seq_TREG_Human1.75976353
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72067577
35ZFX_18555785_ChIP-Seq_MESCs_Mouse1.71279463
36* GABP_19822575_ChIP-Seq_HepG2_Human1.68604761
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63598476
38* ELK1_19687146_ChIP-ChIP_HELA_Human1.59231779
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.59168945
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59139676
41CIITA_25753668_ChIP-Seq_RAJI_Human1.56999119
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56106088
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53318718
44KDM5A_27292631_Chip-Seq_BREAST_Human1.50279318
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49746351
46SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.49548274
47TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.47341566
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44923792
49NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40888121
50* SRF_21415370_ChIP-Seq_HL-1_Mouse1.40485817
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39739517
52PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.38251747
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.37979274
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.37276689
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37020852
56* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36331562
57KLF4_18555785_ChIP-Seq_MESCs_Mouse1.36238959
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31291081
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30993936
60FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.29788237
61TFEB_21752829_ChIP-Seq_HELA_Human1.28042759
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26793028
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25484088
64HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.25224787
65SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21560777
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.21319768
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20895906
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19224700
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.18335133
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17983112
71* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17690348
72TP63_19390658_ChIP-ChIP_HaCaT_Human1.17383201
73SOX17_20123909_ChIP-Seq_XEN_Mouse1.15630140
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.13527585
75* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.13402004
76* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13022562
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.12409930
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12176159
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.12136465
80ESR1_15608294_ChIP-ChIP_MCF-7_Human1.11728251
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10917247
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08903740
83CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.05239630
84TCF3_18692474_ChIP-Seq_MEFs_Mouse1.04331451
85E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04005347
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03155676
87ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03071102
88NANOG_21062744_ChIP-ChIP_HESCs_Human0.99341585
89ZNF263_19887448_ChIP-Seq_K562_Human0.99232194
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.96255432
91VDR_21846776_ChIP-Seq_THP-1_Human0.95679371
92TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.95403533
93* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93623108
94TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93603642
95POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91805933
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91555867
97KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.90707930
98KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.90707930
99KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.90707930
100HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.90469714
101CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89751870
102SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.88762402
103CHD1_26751641_Chip-Seq_LNCaP_Human0.88213845
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87707426
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86527271
106EWS_26573619_Chip-Seq_HEK293_Human0.86297580
107ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85394690
108ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.84631372
109MYC_18940864_ChIP-ChIP_HL60_Human0.84560240
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.83849344
111OCT4_18692474_ChIP-Seq_MEFs_Mouse0.83085175
112NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.81409993
113ELK1_22589737_ChIP-Seq_MCF10A_Human0.80029759
114CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.78301765
115NOTCH1_21737748_ChIP-Seq_TLL_Human0.75290203
116HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.74592952
117SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.74058243
118CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.71714257

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.62671360
2MP0004957_abnormal_blastocyst_morpholog4.24693260
3MP0010094_abnormal_chromosome_stability4.19785219
4MP0003111_abnormal_nucleus_morphology3.98184388
5MP0003077_abnormal_cell_cycle3.73078885
6MP0010352_gastrointestinal_tract_polyps3.49950983
7MP0008057_abnormal_DNA_replication3.37193499
8MP0008058_abnormal_DNA_repair2.77660874
9MP0003123_paternal_imprinting2.68967346
10MP0001730_embryonic_growth_arrest2.66113284
11MP0008007_abnormal_cellular_replicative2.62587978
12MP0008932_abnormal_embryonic_tissue2.54149568
13MP0000350_abnormal_cell_proliferation2.36283602
14MP0010307_abnormal_tumor_latency2.21989680
15MP0003705_abnormal_hypodermis_morpholog2.15731234
16MP0009697_abnormal_copulation2.05282079
17MP0008877_abnormal_DNA_methylation2.03436642
18MP0000537_abnormal_urethra_morphology1.93742831
19MP0001672_abnormal_embryogenesis/_devel1.93066338
20MP0005380_embryogenesis_phenotype1.93066338
21MP0001697_abnormal_embryo_size1.92191737
22MP0004197_abnormal_fetal_growth/weight/1.88993052
23MP0002084_abnormal_developmental_patter1.83678465
24MP0002396_abnormal_hematopoietic_system1.79624758
25MP0005076_abnormal_cell_differentiation1.78573339
26MP0003984_embryonic_growth_retardation1.78409364
27MP0002085_abnormal_embryonic_tissue1.75884025
28MP0002088_abnormal_embryonic_growth/wei1.75361953
29MP0002080_prenatal_lethality1.74636055
30MP0003567_abnormal_fetal_cardiomyocyte1.72159298
31MP0002086_abnormal_extraembryonic_tissu1.65625016
32MP0006292_abnormal_olfactory_placode1.65214545
33MP0003786_premature_aging1.65181316
34MP0004808_abnormal_hematopoietic_stem1.52736331
35MP0003121_genomic_imprinting1.51622280
36MP0010030_abnormal_orbit_morphology1.50619546
37MP0000490_abnormal_crypts_of1.49594341
38MP0003890_abnormal_embryonic-extraembry1.49122222
39MP0009053_abnormal_anal_canal1.48011176
40MP0001293_anophthalmia1.41770481
41MP0008789_abnormal_olfactory_epithelium1.40935720
42MP0006035_abnormal_mitochondrial_morpho1.40400687
43MP0001529_abnormal_vocalization1.37508506
44MP0000313_abnormal_cell_death1.32302658
45MP0002019_abnormal_tumor_incidence1.29105225
46MP0003566_abnormal_cell_adhesion1.28374006
47MP0002233_abnormal_nose_morphology1.22326545
48MP0002938_white_spotting1.21453461
49MP0006054_spinal_hemorrhage1.20966095
50MP0003119_abnormal_digestive_system1.19815990
51MP0009379_abnormal_foot_pigmentation1.19415433
52MP0005499_abnormal_olfactory_system1.13623476
53MP0005394_taste/olfaction_phenotype1.13623476
54MP0005023_abnormal_wound_healing1.12787793
55MP0002210_abnormal_sex_determination1.11224507
56MP0008995_early_reproductive_senescence1.10900733
57MP0003806_abnormal_nucleotide_metabolis1.09738920
58MP0003186_abnormal_redox_activity1.07890698
59MP0010234_abnormal_vibrissa_follicle1.05008948
60MP0009672_abnormal_birth_weight1.03792923
61MP0001849_ear_inflammation1.03273983
62MP0003937_abnormal_limbs/digits/tail_de1.02278870
63MP0000733_abnormal_muscle_development1.00978843
64MP0001145_abnormal_male_reproductive1.00255058
65MP0002111_abnormal_tail_morphology0.97514098
66MP0000049_abnormal_middle_ear0.96972157
67MP0000703_abnormal_thymus_morphology0.94529162
68MP0001915_intracranial_hemorrhage0.93191741
69MP0003385_abnormal_body_wall0.91912588
70MP0000358_abnormal_cell_content/0.91752408
71MP0009333_abnormal_splenocyte_physiolog0.91466067
72MP0003718_maternal_effect0.91455335
73MP0002092_abnormal_eye_morphology0.90767499
74MP0003221_abnormal_cardiomyocyte_apopto0.89880846
75MP0003315_abnormal_perineum_morphology0.89724222
76MP0002877_abnormal_melanocyte_morpholog0.89262088
77MP0008438_abnormal_cutaneous_collagen0.89216181
78MP0002102_abnormal_ear_morphology0.88420633
79MP0009703_decreased_birth_body0.88020790
80MP0000428_abnormal_craniofacial_morphol0.87647480
81MP0004133_heterotaxia0.87105290
82MP0003698_abnormal_male_reproductive0.86678456
83MP0002697_abnormal_eye_size0.85827345
84MP0006072_abnormal_retinal_apoptosis0.85410666
85MP0001188_hyperpigmentation0.85187183
86MP0002234_abnormal_pharynx_morphology0.85158560
87MP0005623_abnormal_meninges_morphology0.83882531
88MP0006036_abnormal_mitochondrial_physio0.83487910
89MP0005187_abnormal_penis_morphology0.83300321
90MP0003115_abnormal_respiratory_system0.82819794
91MP0002653_abnormal_ependyma_morphology0.82519830
92MP0005384_cellular_phenotype0.82494658
93MP0000372_irregular_coat_pigmentation0.82208416
94MP0000579_abnormal_nail_morphology0.82188602
95MP0003136_yellow_coat_color0.81524302
96MP0001929_abnormal_gametogenesis0.80327263
97MP0000647_abnormal_sebaceous_gland0.80248079
98MP0001545_abnormal_hematopoietic_system0.79273723
99MP0005397_hematopoietic_system_phenotyp0.79273723
100MP0005621_abnormal_cell_physiology0.78699854
101MP0000653_abnormal_sex_gland0.78630894
102MP0001346_abnormal_lacrimal_gland0.78160355
103MP0001119_abnormal_female_reproductive0.77799340
104MP0000858_altered_metastatic_potential0.76742104
105MP0004147_increased_porphyrin_level0.75740568
106MP0001727_abnormal_embryo_implantation0.74137478
107MP0002751_abnormal_autonomic_nervous0.73630872
108MP0000477_abnormal_intestine_morphology0.72630196
109MP0001286_abnormal_eye_development0.72215443
110MP0005391_vision/eye_phenotype0.72134459
111MP0002161_abnormal_fertility/fecundity0.72086822
112MP0001299_abnormal_eye_distance/0.71568699
113MP0008770_decreased_survivor_rate0.70921589
114MP0009278_abnormal_bone_marrow0.70751741
115MP0004233_abnormal_muscle_weight0.70203983
116MP0002925_abnormal_cardiovascular_devel0.70198116
117MP0000432_abnormal_head_morphology0.69432986
118MP0002722_abnormal_immune_system0.69313462
119MP0000566_synostosis0.69143626
120MP0002398_abnormal_bone_marrow0.68864172
121MP0000762_abnormal_tongue_morphology0.68432009
122MP0003763_abnormal_thymus_physiology0.68358594
123MP0001661_extended_life_span0.68252278
124MP0002160_abnormal_reproductive_system0.65984890
125MP0005501_abnormal_skin_physiology0.65882080
126MP0002163_abnormal_gland_morphology0.64503208
127MP0003861_abnormal_nervous_system0.62449869
128MP0003935_abnormal_craniofacial_develop0.61869027
129MP0000750_abnormal_muscle_regeneration0.61388120
130MP0003941_abnormal_skin_development0.60323970
131MP0005367_renal/urinary_system_phenotyp0.59721530
132MP0000516_abnormal_urinary_system0.59721530
133MP0003942_abnormal_urinary_system0.58335334
134MP0003448_altered_tumor_morphology0.57453424
135MP0000689_abnormal_spleen_morphology0.56845601
136MP0002282_abnormal_trachea_morphology0.56055044
137MP0003755_abnormal_palate_morphology0.52903374

Predicted human phenotypes

RankGene SetZ-score
1Colon cancer (HP:0003003)4.14147993
2Birth length less than 3rd percentile (HP:0003561)4.03691604
3Ependymoma (HP:0002888)3.93782228
4Reticulocytopenia (HP:0001896)3.79754607
5Selective tooth agenesis (HP:0001592)3.77944720
6Medulloblastoma (HP:0002885)3.47474084
7Abnormality of cells of the erythroid lineage (HP:0012130)3.26310457
8Abnormality of the anterior horn cell (HP:0006802)3.13024594
9Degeneration of anterior horn cells (HP:0002398)3.13024594
10Breast hypoplasia (HP:0003187)3.00505602
11Microvesicular hepatic steatosis (HP:0001414)2.97672315
12Deviation of the thumb (HP:0009603)2.89345227
13Proximal placement of thumb (HP:0009623)2.86315632
14Astrocytoma (HP:0009592)2.86256869
15Abnormality of the astrocytes (HP:0100707)2.86256869
16Abnormal number of erythroid precursors (HP:0012131)2.82146202
17Cortical dysplasia (HP:0002539)2.81757967
18Chromsome breakage (HP:0040012)2.81361620
19Agnosia (HP:0010524)2.78349491
20Increased serum pyruvate (HP:0003542)2.74569716
21Rhabdomyosarcoma (HP:0002859)2.73764237
22Patellar aplasia (HP:0006443)2.73508416
23Abnormality of glycolysis (HP:0004366)2.71835899
24Abnormality of the labia minora (HP:0012880)2.68643571
25Oral leukoplakia (HP:0002745)2.64628625
26Carpal bone hypoplasia (HP:0001498)2.60773985
27Aplasia/Hypoplasia of the patella (HP:0006498)2.58315310
28Neoplasm of the pancreas (HP:0002894)2.54185983
29Basal cell carcinoma (HP:0002671)2.52202695
30Increased nuchal translucency (HP:0010880)2.46412605
31Chromosomal breakage induced by crosslinking agents (HP:0003221)2.45738838
32Biliary tract neoplasm (HP:0100574)2.45497580
33Abnormality of chromosome stability (HP:0003220)2.45346695
34Missing ribs (HP:0000921)2.44464984
35Trismus (HP:0000211)2.43615171
3611 pairs of ribs (HP:0000878)2.42693613
37Increased hepatocellular lipid droplets (HP:0006565)2.42560995
38Absent thumb (HP:0009777)2.41433361
39Glioma (HP:0009733)2.41009912
40Abnormal number of incisors (HP:0011064)2.40939045
41Nephroblastoma (Wilms tumor) (HP:0002667)2.40428938
42Abnormality of the calcaneus (HP:0008364)2.36217767
43Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.34791840
44Short 4th metacarpal (HP:0010044)2.34791840
45Absent radius (HP:0003974)2.33404148
46Atresia of the external auditory canal (HP:0000413)2.31886589
47Aplastic anemia (HP:0001915)2.30880805
48Glossoptosis (HP:0000162)2.28284480
49Multiple enchondromatosis (HP:0005701)2.26607197
50Embryonal renal neoplasm (HP:0011794)2.26502767
51Acute necrotizing encephalopathy (HP:0006965)2.25711782
52Rough bone trabeculation (HP:0100670)2.24873503
53Meckel diverticulum (HP:0002245)2.22213385
54Acute encephalopathy (HP:0006846)2.20734151
55Macrocytic anemia (HP:0001972)2.20696405
56Abnormality of the duodenum (HP:0002246)2.19444896
57Pelvic girdle muscle weakness (HP:0003749)2.18760521
58Angiofibromas (HP:0010615)2.18462347
59Adenoma sebaceum (HP:0009720)2.18462347
60Pallor (HP:0000980)2.18173404
61Aplasia involving forearm bones (HP:0009822)2.16526553
62Absent forearm bone (HP:0003953)2.16526553
63Abnormal mitochondria in muscle tissue (HP:0008316)2.15960002
64Ankle contracture (HP:0006466)2.15752201
65Abnormality of the carotid arteries (HP:0005344)2.15607097
66Amaurosis fugax (HP:0100576)2.15482809
67Lipid accumulation in hepatocytes (HP:0006561)2.15371166
68Cutaneous melanoma (HP:0012056)2.13534280
69Neoplasm of striated muscle (HP:0009728)2.12876479
70Neoplasm of the oral cavity (HP:0100649)2.12803149
71Abnormality of the ileum (HP:0001549)2.10513950
72Myelodysplasia (HP:0002863)2.08878520
73Triphalangeal thumb (HP:0001199)2.08459470
74Amniotic constriction ring (HP:0009775)2.06215470
75Abnormality of placental membranes (HP:0011409)2.06215470
76Squamous cell carcinoma (HP:0002860)2.05506006
77Facial cleft (HP:0002006)2.05310246
78Abnormality of the preputium (HP:0100587)2.05065278
79Increased CSF lactate (HP:0002490)2.03958421
80Aplasia/hypoplasia of the humerus (HP:0006507)2.02478590
81Atrophy/Degeneration involving motor neurons (HP:0007373)2.01737885
82Neoplasm of the colon (HP:0100273)2.00756214
83Gastrointestinal carcinoma (HP:0002672)1.99910957
84Malignant gastrointestinal tract tumors (HP:0006749)1.99910957
85Ovarian neoplasm (HP:0100615)1.98750757
86Ectopic kidney (HP:0000086)1.98196712
87Aplasia/Hypoplasia of the uvula (HP:0010293)1.97347494
88Overlapping toe (HP:0001845)1.95508540
89Shoulder girdle muscle weakness (HP:0003547)1.94848452
90Aplasia/Hypoplasia of the sacrum (HP:0008517)1.94719963
91Horseshoe kidney (HP:0000085)1.93316612
92High pitched voice (HP:0001620)1.93150869
93Premature graying of hair (HP:0002216)1.93090905
94Duodenal stenosis (HP:0100867)1.92896749
95Small intestinal stenosis (HP:0012848)1.92896749
96Volvulus (HP:0002580)1.92740642
97Cerebral hypomyelination (HP:0006808)1.92269414
98Cerebral edema (HP:0002181)1.90097304
99Slender long bone (HP:0003100)1.89827417
100Increased serum lactate (HP:0002151)1.89698900
101Postnatal microcephaly (HP:0005484)1.89451186
102Impulsivity (HP:0100710)1.88724231
103Cafe-au-lait spot (HP:0000957)1.88063637
104Neoplasm of the rectum (HP:0100743)1.87781149
105Increased density of long bones (HP:0006392)1.85485440
106Microglossia (HP:0000171)1.85383444
107Facial hemangioma (HP:0000329)1.84551984
108Tracheoesophageal fistula (HP:0002575)1.83651160
109Thrombocytosis (HP:0001894)1.83034528
110Intestinal polyp (HP:0005266)1.81194288
111Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.80083294
112Hepatocellular necrosis (HP:0001404)1.79896336
113Short humerus (HP:0005792)1.79046810
114Aplasia/Hypoplasia of the sternum (HP:0006714)1.78188815
115Intestinal polyposis (HP:0200008)1.77220542
116Microretrognathia (HP:0000308)1.77096450
117Mitochondrial inheritance (HP:0001427)1.77037116
118Freckling (HP:0001480)1.76854673
119Supernumerary spleens (HP:0009799)1.76618482
120Abnormal lung lobation (HP:0002101)1.76439813
121Abnormality of the hip-girdle musculature (HP:0001445)1.75615675
122Abnormality of the musculature of the pelvis (HP:0001469)1.75615675
123Stenosis of the external auditory canal (HP:0000402)1.74915194
124Progressive external ophthalmoplegia (HP:0000590)1.73989824
125Secondary amenorrhea (HP:0000869)1.72862803
126Abnormality of methionine metabolism (HP:0010901)1.72672191
127Protrusio acetabuli (HP:0003179)1.72660904
128Sloping forehead (HP:0000340)1.71209808
129Choanal atresia (HP:0000453)1.71202311
130Progressive muscle weakness (HP:0003323)1.71185843
131Duplication of thumb phalanx (HP:0009942)1.70145697
132Abnormalities of placenta or umbilical cord (HP:0001194)1.66918286
133Hypoplastic pelvis (HP:0008839)1.63924361
134Abnormality of alanine metabolism (HP:0010916)1.63146064
135Hyperalaninemia (HP:0003348)1.63146064
136Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.63146064
137Progressive macrocephaly (HP:0004481)1.62565081
138Short thumb (HP:0009778)1.62274543
139High anterior hairline (HP:0009890)1.61248814
140Spastic diplegia (HP:0001264)1.60471188
141Lactic acidosis (HP:0003128)1.58851477
142Hepatic necrosis (HP:0002605)1.56229462
143Type I transferrin isoform profile (HP:0003642)1.53606003
144Neoplasm of the adrenal gland (HP:0100631)1.52877187
145Hypoplasia of the capital femoral epiphysis (HP:0003090)1.52650681
146Abnormality of the umbilical cord (HP:0010881)1.50937614
147CNS hypomyelination (HP:0003429)1.48231026
148Gonadotropin excess (HP:0000837)1.48033135

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.36077357
2WEE14.00248377
3BUB13.47156858
4EEF2K2.70205321
5NEK22.68477497
6TSSK62.61575312
7NEK12.48258013
8EIF2AK12.44248150
9VRK22.35956521
10PASK2.33203019
11TTK2.19052224
12CDK122.18474282
13PKN22.17149679
14SRPK12.16569112
15RPS6KB22.13616199
16TRIM282.08641135
17SCYL21.99570770
18EPHA21.94588725
19NME21.90895895
20ACVR1B1.82602235
21MKNK11.81353068
22PLK11.79225959
23BRSK21.72278462
24PLK31.66067703
25TGFBR11.64670561
26ATR1.61974621
27MAP3K101.59404880
28AURKB1.57855325
29TESK21.55493424
30TAF11.55148324
31CDK71.54749120
32DYRK31.52276186
33RPS6KA41.51884987
34MAP3K81.49314611
35PAK41.41803101
36EIF2AK31.39913974
37STK101.39597474
38CDK41.36937131
39NME11.34743469
40BCR1.34458315
41CHEK11.30516851
42PLK41.29387335
43ALK1.29381151
44LRRK21.25520603
45CHEK21.19742851
46TESK11.15297957
47AURKA1.06850228
48BRD41.05440493
49FLT31.03237173
50TLK11.00318539
51TRIB30.98379716
52BRSK10.97914304
53PNCK0.97040793
54CDK60.96641972
55MKNK20.94237150
56MAP2K70.92384181
57ATM0.92230964
58EIF2AK20.92109527
59VRK10.91967575
60CDK20.90329552
61MAP3K40.89488669
62TTN0.89400508
63STK40.85813113
64STK30.83034228
65NUAK10.82708697
66ERBB40.78583689
67MTOR0.76924403
68SMG10.76901232
69CSNK1G30.75864021
70CSNK1G10.75292181
71PIM10.74141443
72PAK20.73689213
73FGFR10.72934014
74BRAF0.72591820
75CSNK2A20.71940847
76PAK10.69648550
77CDK190.69009951
78MELK0.68170663
79ERBB30.67189974
80LIMK10.65930930
81DYRK20.65065027
82CDK10.64863211
83PDK30.61805966
84PDK40.61805966
85CSNK1A1L0.59517532
86ILK0.57651325
87CLK10.57391481
88STK160.56703809
89CSNK1G20.55757389
90WNK30.53823511
91CSNK2A10.53699392
92PRKCI0.52835048
93CSNK1E0.51900836
94CDK180.51561881
95LATS20.50090940
96PLK20.49872533
97CDK140.48433434
98ZAK0.47850491
99CDK11A0.47486356
100CDK30.45798086
101CDK150.45644776
102CCNB10.43956268
103MINK10.43787651
104PTK60.43648143
105MST1R0.43626393
106DAPK10.43059889
107BCKDK0.42955944
108MAP4K20.42667096
109PRKDC0.42571660
110MAPKAPK30.42459903
111BMPR1B0.42339946
112KSR10.41585510
113MAP3K120.41018050
114PDGFRA0.40333156
115MET0.40304756
116MAP2K30.39174924
117AKT20.39152797
118RPS6KA50.37691039
119CSNK1D0.36053408
120PIM20.35763841
121LATS10.34999150
122MAPKAPK50.34481789
123CDK80.32209986
124BMX0.31833114
125PBK0.27823380
126MST40.27685910
127STK38L0.27446214
128GRK60.27209870
129MAP4K10.26703209
130MAPK140.26239268
131KDR0.25745266
132PDK20.25276193
133DDR20.24633130
134ZAP700.23646111
135MAPKAPK20.20319252
136MAPK10.19189833

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.62091413
2Mismatch repair_Homo sapiens_hsa034304.05088348
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.68985337
4RNA transport_Homo sapiens_hsa030133.47081901
5Spliceosome_Homo sapiens_hsa030403.40561043
6Ribosome_Homo sapiens_hsa030103.21975425
7Proteasome_Homo sapiens_hsa030503.00496285
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.00049234
9One carbon pool by folate_Homo sapiens_hsa006702.97973971
10Cell cycle_Homo sapiens_hsa041102.81365426
11Base excision repair_Homo sapiens_hsa034102.73510498
12Nucleotide excision repair_Homo sapiens_hsa034202.69716606
13RNA polymerase_Homo sapiens_hsa030202.60427788
14Homologous recombination_Homo sapiens_hsa034402.48375952
15mRNA surveillance pathway_Homo sapiens_hsa030152.08989293
16Non-homologous end-joining_Homo sapiens_hsa034502.07915156
17Pyrimidine metabolism_Homo sapiens_hsa002402.00195006
18Protein export_Homo sapiens_hsa030601.85767597
19Fanconi anemia pathway_Homo sapiens_hsa034601.82428107
20RNA degradation_Homo sapiens_hsa030181.82087566
21Basal transcription factors_Homo sapiens_hsa030221.68203966
22p53 signaling pathway_Homo sapiens_hsa041151.65867592
23Parkinsons disease_Homo sapiens_hsa050121.61913216
24Oxidative phosphorylation_Homo sapiens_hsa001901.52132939
25Pyruvate metabolism_Homo sapiens_hsa006201.41153074
26Huntingtons disease_Homo sapiens_hsa050161.37368918
27Systemic lupus erythematosus_Homo sapiens_hsa053221.32455664
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32317008
29Epstein-Barr virus infection_Homo sapiens_hsa051691.29361393
30Viral carcinogenesis_Homo sapiens_hsa052031.27298746
31Steroid biosynthesis_Homo sapiens_hsa001001.24912903
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21090013
33Propanoate metabolism_Homo sapiens_hsa006401.16384734
34Antigen processing and presentation_Homo sapiens_hsa046121.10436451
35Oocyte meiosis_Homo sapiens_hsa041141.07113523
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04272962
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00889516
38MicroRNAs in cancer_Homo sapiens_hsa052060.99047504
39Fatty acid elongation_Homo sapiens_hsa000620.98817407
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.97879466
41HTLV-I infection_Homo sapiens_hsa051660.96727395
42Biosynthesis of amino acids_Homo sapiens_hsa012300.96027116
43Selenocompound metabolism_Homo sapiens_hsa004500.95525529
44Purine metabolism_Homo sapiens_hsa002300.93985249
45Small cell lung cancer_Homo sapiens_hsa052220.93657961
46Thyroid cancer_Homo sapiens_hsa052160.92799145
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91732988
48Herpes simplex infection_Homo sapiens_hsa051680.88758793
49Vitamin B6 metabolism_Homo sapiens_hsa007500.84204506
50Alzheimers disease_Homo sapiens_hsa050100.82914336
51Hippo signaling pathway_Homo sapiens_hsa043900.81314315
52Cyanoamino acid metabolism_Homo sapiens_hsa004600.76050754
53Colorectal cancer_Homo sapiens_hsa052100.75055029
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.74648845
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73777959
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73198369
57Chronic myeloid leukemia_Homo sapiens_hsa052200.70108032
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69674501
59TGF-beta signaling pathway_Homo sapiens_hsa043500.69091352
60Legionellosis_Homo sapiens_hsa051340.67876090
61Pentose phosphate pathway_Homo sapiens_hsa000300.67108228
62Basal cell carcinoma_Homo sapiens_hsa052170.65449134
63Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65393746
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65325922
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64214391
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.63919898
67Bladder cancer_Homo sapiens_hsa052190.63533785
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61001241
69Adherens junction_Homo sapiens_hsa045200.60080423
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.59671788
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57708978
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56928820
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.56913524
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55791654
75Alcoholism_Homo sapiens_hsa050340.55045165
76Carbon metabolism_Homo sapiens_hsa012000.54504091
77Viral myocarditis_Homo sapiens_hsa054160.53903941
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52720193
79Apoptosis_Homo sapiens_hsa042100.52505775
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51787373
81Metabolic pathways_Homo sapiens_hsa011000.51399045
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51012229
83Shigellosis_Homo sapiens_hsa051310.50334609
84mTOR signaling pathway_Homo sapiens_hsa041500.49579476
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49246919
86HIF-1 signaling pathway_Homo sapiens_hsa040660.47599178
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47153026
88Proteoglycans in cancer_Homo sapiens_hsa052050.46561100
89Notch signaling pathway_Homo sapiens_hsa043300.44191807
90Fatty acid metabolism_Homo sapiens_hsa012120.42781522
91Hepatitis B_Homo sapiens_hsa051610.42566233
92Pathways in cancer_Homo sapiens_hsa052000.42471302
93Hedgehog signaling pathway_Homo sapiens_hsa043400.42038083
94N-Glycan biosynthesis_Homo sapiens_hsa005100.41492937
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.41206087
96Cardiac muscle contraction_Homo sapiens_hsa042600.38252036
97Tight junction_Homo sapiens_hsa045300.38225864
98Prostate cancer_Homo sapiens_hsa052150.37307881
99Arginine and proline metabolism_Homo sapiens_hsa003300.36699269
100Non-small cell lung cancer_Homo sapiens_hsa052230.35602206
101Pancreatic cancer_Homo sapiens_hsa052120.31828606
102Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31551878
103Acute myeloid leukemia_Homo sapiens_hsa052210.31249746
104Glutathione metabolism_Homo sapiens_hsa004800.30781880
105Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30502607
106Endometrial cancer_Homo sapiens_hsa052130.29944740
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.28048351
108Focal adhesion_Homo sapiens_hsa045100.27528293
109Measles_Homo sapiens_hsa051620.27440056
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.26980415
111Wnt signaling pathway_Homo sapiens_hsa043100.25402817
112Melanoma_Homo sapiens_hsa052180.25336133
113Folate biosynthesis_Homo sapiens_hsa007900.25218928
114Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24156773
115ECM-receptor interaction_Homo sapiens_hsa045120.23971568
116Sulfur metabolism_Homo sapiens_hsa009200.21552787
117NF-kappa B signaling pathway_Homo sapiens_hsa040640.18637438
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.18276800
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.17971436
120Primary immunodeficiency_Homo sapiens_hsa053400.17146831
121Sulfur relay system_Homo sapiens_hsa041220.16912534
122Fructose and mannose metabolism_Homo sapiens_hsa000510.16464313
123Influenza A_Homo sapiens_hsa051640.16429172
124Lysine degradation_Homo sapiens_hsa003100.15546148
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.15262421
126FoxO signaling pathway_Homo sapiens_hsa040680.14706575
127Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.14078453
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.14013863
129Renin-angiotensin system_Homo sapiens_hsa046140.13978170
130Butanoate metabolism_Homo sapiens_hsa006500.13649134
131beta-Alanine metabolism_Homo sapiens_hsa004100.13450983
132Peroxisome_Homo sapiens_hsa041460.12786527
133Regulation of autophagy_Homo sapiens_hsa041400.09314813
134Vibrio cholerae infection_Homo sapiens_hsa051100.08716033
135Galactose metabolism_Homo sapiens_hsa000520.08079963

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