CCR8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tolerance induction (GO:0002507)9.71111807
2negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)8.60730367
3negative regulation of T-helper cell differentiation (GO:0045623)8.60730367
4positive regulation of granulocyte differentiation (GO:0030854)8.53990965
5cellular response to interleukin-15 (GO:0071350)8.17691285
6regulation of podosome assembly (GO:0071801)8.07792265
7negative thymic T cell selection (GO:0045060)7.42358982
8response to interleukin-15 (GO:0070672)7.34643460
9negative T cell selection (GO:0043383)7.26358126
10regulation of isotype switching to IgG isotypes (GO:0048302)7.06231902
11negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)7.02295948
12positive thymic T cell selection (GO:0045059)6.87442163
13positive regulation of gamma-delta T cell activation (GO:0046645)6.86519322
14leukocyte aggregation (GO:0070486)6.70279721
15lymphocyte costimulation (GO:0031294)6.60347919
16T cell lineage commitment (GO:0002360)6.59898806
17thymic T cell selection (GO:0045061)6.59680887
18T cell costimulation (GO:0031295)6.48615254
19cytokine production involved in immune response (GO:0002367)6.32718321
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.28659360
21negative regulation of cell killing (GO:0031342)6.28659360
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.18265908
23sequestering of actin monomers (GO:0042989)6.17207280
24regulation of interleukin-13 production (GO:0032656)6.16880594
25CD4-positive, alpha-beta T cell differentiation (GO:0043367)6.16306221
26negative regulation of alpha-beta T cell differentiation (GO:0046639)6.02292900
27negative regulation of acute inflammatory response (GO:0002674)6.02150445
28regulation of gamma-delta T cell differentiation (GO:0045586)5.87738418
29positive regulation of chemokine biosynthetic process (GO:0045080)5.87669387
30regulation of MHC class II biosynthetic process (GO:0045346)5.76024346
31positive T cell selection (GO:0043368)5.72844959
32T cell selection (GO:0045058)5.69066671
33regulation of gamma-delta T cell activation (GO:0046643)5.68153535
34CD4-positive, alpha-beta T cell activation (GO:0035710)5.67865173
35positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.66494143
36positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.63682536
37response to mercury ion (GO:0046689)5.49160897
38production of molecular mediator of immune response (GO:0002440)5.46060751
39regulation of T cell tolerance induction (GO:0002664)5.42657536
40T cell receptor signaling pathway (GO:0050852)5.37494137
41regulation of granulocyte differentiation (GO:0030852)5.37380150
42alpha-beta T cell differentiation (GO:0046632)5.36146696
43cytokine biosynthetic process (GO:0042089)5.06429374
44defense response to protozoan (GO:0042832)4.95625174
45positive regulation of B cell proliferation (GO:0030890)4.84319839
46regulation of proton transport (GO:0010155)4.81729266
47alpha-beta T cell activation (GO:0046631)4.71485287
48T cell mediated immunity (GO:0002456)4.70286575
49regulation of B cell proliferation (GO:0030888)4.60285484
50positive regulation of tolerance induction (GO:0002645)4.56333287
51antigen receptor-mediated signaling pathway (GO:0050851)4.49746050
52regulation of isotype switching (GO:0045191)4.48090046
53DNA deamination (GO:0045006)4.47878817
54regulation of chemokine biosynthetic process (GO:0045073)4.46566844
55antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.45128271
56antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.45128271
57regulation of T cell receptor signaling pathway (GO:0050856)4.41492290
58regulation of immunoglobulin mediated immune response (GO:0002889)4.37923658
59T cell migration (GO:0072678)4.35915330
60negative regulation of alpha-beta T cell activation (GO:0046636)4.34895513
61regulation of immunoglobulin production (GO:0002637)4.31896407
62response to protozoan (GO:0001562)4.30746793
63regulation of interleukin-2 biosynthetic process (GO:0045076)4.28229026
64positive regulation of B cell differentiation (GO:0045579)4.28135706
65negative regulation of B cell activation (GO:0050869)4.28107049
66positive regulation of natural killer cell mediated immunity (GO:0002717)4.27217497
67positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.27217497
68negative regulation of B cell proliferation (GO:0030889)4.26394926
69positive regulation of B cell activation (GO:0050871)4.23125491
70regulation of B cell mediated immunity (GO:0002712)4.21992500
71positive regulation of immunoglobulin mediated immune response (GO:0002891)4.18145393
72positive regulation of B cell mediated immunity (GO:0002714)4.18145393
73regulation of B cell receptor signaling pathway (GO:0050855)4.10003227
74cytokine metabolic process (GO:0042107)4.06802732
75regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)4.06674119
76regulation of antigen receptor-mediated signaling pathway (GO:0050854)4.06173635
77CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)4.05937060
78regulation of natural killer cell mediated immunity (GO:0002715)4.05702033
79regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.05702033
80regulation of regulatory T cell differentiation (GO:0045589)3.95722507
81regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.94989149
82positive regulation of isotype switching (GO:0045830)3.94562108
83positive regulation of immunoglobulin production (GO:0002639)3.93035015
84regulation of B cell activation (GO:0050864)3.92199818
85regulation of tolerance induction (GO:0002643)3.91812257
86negative regulation of T cell differentiation (GO:0045581)3.91453765
87positive regulation of alpha-beta T cell proliferation (GO:0046641)3.89544082
88regulation of chronic inflammatory response (GO:0002676)3.86974780
89regulation of macrophage activation (GO:0043030)3.84592377
90regulation of leukocyte mediated cytotoxicity (GO:0001910)3.81059834
91regulation of T-helper cell differentiation (GO:0045622)3.80922876
92interferon-gamma production (GO:0032609)3.80426857
93antigen processing and presentation of endogenous antigen (GO:0019883)3.80036893
94positive regulation of interleukin-2 production (GO:0032743)3.79945550
95regulation of alpha-beta T cell proliferation (GO:0046640)3.74039465
96positive regulation of organelle assembly (GO:1902117)3.71011579
97regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.70917519
98CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.69814605
99T-helper cell differentiation (GO:0042093)3.69814605
100positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.69091024
101regulation of immunoglobulin secretion (GO:0051023)3.66493304
102negative regulation of T cell mediated immunity (GO:0002710)3.63573660
103regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)3.63504719
104positive regulation of production of molecular mediator of immune response (GO:0002702)3.60943756
105positive regulation of interleukin-10 production (GO:0032733)3.60668013
106positive regulation of macrophage differentiation (GO:0045651)3.58650618
107tumor necrosis factor-mediated signaling pathway (GO:0033209)3.57159355
108negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.52492005
109regulation of response to interferon-gamma (GO:0060330)3.52055439
110regulation of T cell mediated cytotoxicity (GO:0001914)3.51847520
111regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.50097290
112regulation of lymphocyte mediated immunity (GO:0002706)3.49468369
113positive regulation of lamellipodium assembly (GO:0010592)3.48402502
114T cell activation involved in immune response (GO:0002286)3.47732081
115innate immune response in mucosa (GO:0002227)3.47212866
116negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.45151000
117positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.45019505
118positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.44486034
119negative regulation of lymphocyte mediated immunity (GO:0002707)3.44316843
120positive regulation of T cell activation (GO:0050870)3.42031801
121positive regulation of humoral immune response (GO:0002922)3.40850122
122mast cell activation (GO:0045576)3.40685107
123negative regulation of adaptive immune response (GO:0002820)3.38001437
124negative regulation of nitric oxide biosynthetic process (GO:0045019)3.37911610
125positive regulation of lymphocyte mediated immunity (GO:0002708)3.36683650
126natural killer cell activation (GO:0030101)3.36244913
127T cell differentiation (GO:0030217)3.35751580
128positive regulation of DNA recombination (GO:0045911)3.34162041
129regulation of cell killing (GO:0031341)3.33302340
130regulation of interleukin-10 production (GO:0032653)3.32178994
131negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.32063806
132JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.30680282
133negative regulation of T cell receptor signaling pathway (GO:0050860)3.30097605
134type I interferon signaling pathway (GO:0060337)3.28831776
135cellular response to type I interferon (GO:0071357)3.28831776
136response to type I interferon (GO:0034340)3.27804539
137hepatocyte apoptotic process (GO:0097284)3.27794304
138positive regulation of interleukin-4 production (GO:0032753)3.27788942
139positive regulation of activated T cell proliferation (GO:0042104)3.26829282
140kinetochore assembly (GO:0051382)3.26472191
141regulation of B cell differentiation (GO:0045577)3.25269398
142regulation of respiratory burst (GO:0060263)3.23951949
143NIK/NF-kappaB signaling (GO:0038061)3.22782720
144alpha-beta T cell differentiation involved in immune response (GO:0002293)3.21944554
145alpha-beta T cell activation involved in immune response (GO:0002287)3.21944554
146T cell differentiation involved in immune response (GO:0002292)3.21944554
147regulation of defense response to virus by virus (GO:0050690)3.20280117
148T cell activation (GO:0042110)3.18879826
149regulation of activated T cell proliferation (GO:0046006)3.17405092
150positive regulation of cell killing (GO:0031343)3.17105693
151antigen processing and presentation via MHC class Ib (GO:0002475)3.17031325
152regulation of type I interferon-mediated signaling pathway (GO:0060338)3.16986058
153lymphocyte mediated immunity (GO:0002449)3.13712389
154negative regulation of lymphocyte differentiation (GO:0045620)3.03119790

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.41159684
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.95695529
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.13096056
4STAT4_19710469_ChIP-ChIP_TH1__Mouse3.97297413
5* STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.96271951
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.85914247
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.61574242
8RUNX_20019798_ChIP-Seq_JUKART_Human3.55459822
9MYB_26560356_Chip-Seq_TH2_Human3.25797276
10MYC_22102868_ChIP-Seq_BL_Human3.23611503
11FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.07459484
12MAF_26560356_Chip-Seq_TH1_Human3.07166153
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.85568668
14MYB_26560356_Chip-Seq_TH1_Human2.82706558
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.80522737
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.78215013
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.77923200
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.76321363
19UTX_26944678_Chip-Seq_JUKART_Human2.74819003
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.63030781
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.60076685
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.47822981
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.46988486
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.33959605
25MAF_26560356_Chip-Seq_TH2_Human2.28896463
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.23638097
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21175246
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.16613463
29E2F7_22180533_ChIP-Seq_HELA_Human2.04345865
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03084364
31FLI1_27457419_Chip-Seq_LIVER_Mouse2.01972484
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97887128
33EST1_17652178_ChIP-ChIP_JURKAT_Human1.96099024
34GATA3_27048872_Chip-Seq_THYMUS_Human1.93962555
35KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.93397075
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.91952541
37DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.81770422
38SMAD_19615063_ChIP-ChIP_OVARY_Human1.81752888
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81467993
40E2F4_17652178_ChIP-ChIP_JURKAT_Human1.76676249
41SPI1_23547873_ChIP-Seq_NB4_Human1.74296451
42E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70851215
43VDR_21846776_ChIP-Seq_THP-1_Human1.65482617
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.62476975
45IRF1_19129219_ChIP-ChIP_H3396_Human1.62279292
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.61173102
47NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.56447791
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53909609
49KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51986415
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.50980201
51TCF7_22412390_ChIP-Seq_EML_Mouse1.48410043
52CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.48118577
53SRY_22984422_ChIP-ChIP_TESTIS_Rat1.45393938
54NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.43895847
55PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39742688
56VDR_23849224_ChIP-Seq_CD4+_Human1.39174171
57VDR_24763502_ChIP-Seq_THP-1_Human1.38981670
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38526465
59MYB_21317192_ChIP-Seq_ERMYB_Mouse1.38108332
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38102738
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.37833685
62PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36882837
63RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.34338712
64KDM2B_26808549_Chip-Seq_DND41_Human1.33174496
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30302285
66ELK1_19687146_ChIP-ChIP_HELA_Human1.27478588
67ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26978010
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26325601
69GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25528231
70GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24618848
71SPI1_23127762_ChIP-Seq_K562_Human1.23091426
72GATA3_26560356_Chip-Seq_TH2_Human1.20487433
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19531995
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.17782904
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17507547
76E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15112765
77CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14320286
78GATA3_26560356_Chip-Seq_TH1_Human1.12525954
79EGR1_19032775_ChIP-ChIP_M12_Human1.12477615
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.12344958
81GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09344048
82MYC_18555785_ChIP-Seq_MESCs_Mouse1.07213744
83PU_27001747_Chip-Seq_BMDM_Mouse1.05637898
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05601877
85SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05255415
86FOXP3_21729870_ChIP-Seq_TREG_Human1.05186628
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.02593294
88SCL_19346495_ChIP-Seq_HPC-7_Human1.02345120
89CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00757456
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00446347
91ELK3_25401928_ChIP-Seq_HUVEC_Human0.99863752
92ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99583353
93GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98838681
94DCP1A_22483619_ChIP-Seq_HELA_Human0.98789669
95CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97667580
96PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96730474
97SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.95601188
98NFE2_27457419_Chip-Seq_LIVER_Mouse0.94908531
99FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92397550
100HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92260463
101* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90501537
102CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90237115
103ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90133259
104KDM2B_26808549_Chip-Seq_JURKAT_Human0.90062331
105SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89966540
106VDR_24787735_ChIP-Seq_THP-1_Human0.89641544
107CIITA_25753668_ChIP-Seq_RAJI_Human0.89406418
108PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89067931
109JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.88908330
110OCT4_21477851_ChIP-Seq_ESCs_Mouse0.88782878
111LXR_22292898_ChIP-Seq_THP-1_Human0.88587262
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88549527
113GABP_17652178_ChIP-ChIP_JURKAT_Human0.88197706
114PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87853478
115SALL4_22934838_ChIP-ChIP_CD34+_Human0.87644136
116PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87314651
117ETS1_20019798_ChIP-Seq_JURKAT_Human0.85918290
118SUZ12_27294783_Chip-Seq_NPCs_Mouse0.84870493
119GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.83354607
120HOXB4_20404135_ChIP-ChIP_EML_Mouse0.82779848
121PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.81033520
122GATA1_22025678_ChIP-Seq_K562_Human0.80659376
123LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.80606308
124BCL6_27268052_Chip-Seq_Bcells_Human0.79258422
125GATA1_22383799_ChIP-Seq_G1ME_Mouse0.77791694
126STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.77401725
127VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.75656563
128CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.75337279
129LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.75023927
130EZH2_27294783_Chip-Seq_NPCs_Mouse0.72793931
131MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.72417812
132CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.72362576
133SMRT_27268052_Chip-Seq_Bcells_Human0.72155791
134XRN2_22483619_ChIP-Seq_HELA_Human0.71553221
135TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.71525711
136SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70374507
137TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.69840497
138FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.68601776

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to6.14981425
2MP0003763_abnormal_thymus_physiology5.73451904
3MP0002166_altered_tumor_susceptibility3.50213697
4MP0001835_abnormal_antigen_presentation3.39705471
5MP0000685_abnormal_immune_system3.19345765
6MP0001800_abnormal_humoral_immune3.18318061
7MP0005387_immune_system_phenotype3.13772838
8MP0001790_abnormal_immune_system3.13772838
9MP0009785_altered_susceptibility_to3.10427020
10* MP0005000_abnormal_immune_tolerance3.03014893
11MP0004510_myositis2.93664760
12MP0002933_joint_inflammation2.90327451
13MP0003724_increased_susceptibility_to2.85726286
14MP0006082_CNS_inflammation2.83889905
15MP0009333_abnormal_splenocyte_physiolog2.82480506
16MP0002723_abnormal_immune_serum2.79234755
17MP0005025_abnormal_response_to2.76290526
18MP0002420_abnormal_adaptive_immunity2.73362200
19MP0001819_abnormal_immune_cell2.71236856
20MP0002006_tumorigenesis2.69234498
21MP0002398_abnormal_bone_marrow2.67893381
22MP0001873_stomach_inflammation2.66617687
23MP0003300_gastrointestinal_ulcer2.50996275
24MP0008875_abnormal_xenobiotic_pharmacok2.50362267
25MP0002452_abnormal_antigen_presenting2.43969979
26MP0010155_abnormal_intestine_physiology2.40674836
27MP0000716_abnormal_immune_system2.39363551
28MP0000703_abnormal_thymus_morphology2.36109486
29MP0002405_respiratory_system_inflammati2.35868956
30MP0002722_abnormal_immune_system2.26903422
31MP0005310_abnormal_salivary_gland2.13181996
32MP0001853_heart_inflammation2.12918325
33MP0003866_abnormal_defecation2.12214794
34MP0000689_abnormal_spleen_morphology2.09231361
35MP0004947_skin_inflammation2.08782956
36MP0002277_abnormal_respiratory_mucosa1.94871930
37MP0003303_peritoneal_inflammation1.91837428
38MP0002429_abnormal_blood_cell1.88370814
39MP0003436_decreased_susceptibility_to1.85915280
40MP0002396_abnormal_hematopoietic_system1.78108891
41MP0001845_abnormal_inflammatory_respons1.72267656
42MP0002419_abnormal_innate_immunity1.71451194
43MP0002148_abnormal_hypersensitivity_rea1.63978886
44MP0001348_abnormal_lacrimal_gland1.59022247
45MP0002163_abnormal_gland_morphology1.51296141
46MP0000858_altered_metastatic_potential1.46381195
47MP0008057_abnormal_DNA_replication1.35945393
48MP0008469_abnormal_protein_level1.30429722
49MP0004381_abnormal_hair_follicle1.29353012
50MP0003448_altered_tumor_morphology1.23379046
51MP0001851_eye_inflammation1.22338693
52MP0002009_preneoplasia1.14764274
53MP0005464_abnormal_platelet_physiology1.07067489
54MP0009764_decreased_sensitivity_to1.01724593
55MP0001533_abnormal_skeleton_physiology1.00376180
56MP0005645_abnormal_hypothalamus_physiol0.97830341
57MP0009763_increased_sensitivity_to0.95526040
58MP0005381_digestive/alimentary_phenotyp0.94554880
59MP0000465_gastrointestinal_hemorrhage0.94469227
60MP0002019_abnormal_tumor_incidence0.92678896
61MP0005379_endocrine/exocrine_gland_phen0.91635549
62MP0000490_abnormal_crypts_of0.89768249
63MP0000477_abnormal_intestine_morphology0.88117419
64MP0005023_abnormal_wound_healing0.87426658
65MP0002693_abnormal_pancreas_physiology0.86098715
66MP0000343_altered_response_to0.85977157
67MP0005451_abnormal_body_composition0.82998013
68MP0000604_amyloidosis0.81665441
69MP0010234_abnormal_vibrissa_follicle0.77903224
70MP0002998_abnormal_bone_remodeling0.76345770
71MP0001919_abnormal_reproductive_system0.74040383
72MP0002132_abnormal_respiratory_system0.73997118
73MP0009765_abnormal_xenobiotic_induced0.71806206
74MP0003329_amyloid_beta_deposits0.71211549
75MP0004808_abnormal_hematopoietic_stem0.70095413
76MP0002138_abnormal_hepatobiliary_system0.69100005
77MP0001765_abnormal_ion_homeostasis0.68847934
78MP0008872_abnormal_physiological_respon0.66495157
79MP0002876_abnormal_thyroid_physiology0.65711139
80MP0000249_abnormal_blood_vessel0.65502916
81MP0003045_fibrosis0.63929014
82MP0005076_abnormal_cell_differentiation0.63087443
83MP0002909_abnormal_adrenal_gland0.62963616
84MP0010352_gastrointestinal_tract_polyps0.61628652
85MP0005501_abnormal_skin_physiology0.59266590
86MP0003795_abnormal_bone_structure0.59123868
87MP0001663_abnormal_digestive_system0.58524895
88MP0005397_hematopoietic_system_phenotyp0.55811581
89MP0001545_abnormal_hematopoietic_system0.55811581
90MP0003315_abnormal_perineum_morphology0.54293346
91MP0005584_abnormal_enzyme/coenzyme_acti0.54013272
92MP0008058_abnormal_DNA_repair0.53362903
93MP0005075_abnormal_melanosome_morpholog0.51546105
94MP0003787_abnormal_imprinting0.50797111
95MP0001881_abnormal_mammary_gland0.48919056
96MP0009278_abnormal_bone_marrow0.47628536
97MP0003868_abnormal_feces_composition0.46325371
98MP0008961_abnormal_basal_metabolism0.46291683
99MP0003786_premature_aging0.45871550
100MP0000609_abnormal_liver_physiology0.45159834
101MP0000427_abnormal_hair_cycle0.44471163
102MP0001984_abnormal_olfaction0.43703952
103MP0005165_increased_susceptibility_to0.43591353
104MP0004264_abnormal_extraembryonic_tissu0.42433696
105MP0003186_abnormal_redox_activity0.42389387
106MP0001191_abnormal_skin_condition0.42041598
107MP0001529_abnormal_vocalization0.41816384
108MP0003191_abnormal_cellular_cholesterol0.40301930
109MP0005166_decreased_susceptibility_to0.40025643
110MP0003077_abnormal_cell_cycle0.39212490
111MP0000598_abnormal_liver_morphology0.39085534
112MP0001502_abnormal_circadian_rhythm0.38109444
113MP0000372_irregular_coat_pigmentation0.37664290
114MP0009840_abnormal_foam_cell0.37631948
115MP0008007_abnormal_cellular_replicative0.37518860
116MP0003566_abnormal_cell_adhesion0.36900054
117MP0000313_abnormal_cell_death0.36121409
118MP0000015_abnormal_ear_pigmentation0.35620563
119MP0008873_increased_physiological_sensi0.35299201
120MP0001346_abnormal_lacrimal_gland0.35205625
121MP0005319_abnormal_enzyme/_coenzyme0.34912140
122MP0008569_lethality_at_weaning0.34863760
123MP0001243_abnormal_dermal_layer0.34445189
124MP0001216_abnormal_epidermal_layer0.33597095
125MP0003453_abnormal_keratinocyte_physiol0.32851277
126MP0002136_abnormal_kidney_physiology0.32239097
127MP0002083_premature_death0.32119284
128MP0000627_abnormal_mammary_gland0.31933521
129MP0001299_abnormal_eye_distance/0.30174698

Predicted human phenotypes

RankGene SetZ-score
1Severe combined immunodeficiency (HP:0004430)7.44205620
2IgM deficiency (HP:0002850)7.32065366
3Recurrent bronchitis (HP:0002837)7.21105519
4B lymphocytopenia (HP:0010976)6.69820552
5Abnormality of B cell number (HP:0010975)6.69820552
6T lymphocytopenia (HP:0005403)6.42229550
7Combined immunodeficiency (HP:0005387)6.40726534
8Elevated erythrocyte sedimentation rate (HP:0003565)6.37518771
9IgG deficiency (HP:0004315)6.30344068
10Abnormality of T cell number (HP:0011839)6.16591110
11Stomatitis (HP:0010280)5.53596050
12Abnormality of T cells (HP:0002843)5.39537910
13Fatigue (HP:0012378)5.33813731
14Thyroiditis (HP:0100646)5.02575551
15Myositis (HP:0100614)4.91787291
16IgA deficiency (HP:0002720)4.76203099
17Hypoplasia of the thymus (HP:0000778)4.63227763
18Chronic mucocutaneous candidiasis (HP:0002728)4.50455716
19Recurrent cutaneous fungal infections (HP:0011370)4.50455716
20Chronic diarrhea (HP:0002028)4.50152971
21Abnormality of T cell physiology (HP:0011840)4.36494791
22Lymphopenia (HP:0001888)4.25003747
23Recurrent sinusitis (HP:0011108)4.13890272
24Retrobulbar optic neuritis (HP:0100654)4.10596783
25Optic neuritis (HP:0100653)4.10596783
26Bronchitis (HP:0012387)4.04952880
27Abnormality of cells of the lymphoid lineage (HP:0012140)4.03097439
28Autoimmune hemolytic anemia (HP:0001890)4.00398484
29Abnormality of eosinophils (HP:0001879)3.90000011
30Gastrointestinal stroma tumor (HP:0100723)3.89274867
31Orchitis (HP:0100796)3.87090084
32Aplastic anemia (HP:0001915)3.84986281
33Abnormal delayed hypersensitivity skin test (HP:0002963)3.84629988
34Increased IgM level (HP:0003496)3.82826628
35Recurrent fungal infections (HP:0002841)3.80085273
36Large for gestational age (HP:0001520)3.74427205
37Vasculitis (HP:0002633)3.58061633
38Eczematoid dermatitis (HP:0000976)3.54680318
39Pustule (HP:0200039)3.29544569
40Leukocytosis (HP:0001974)3.23923359
41Gastrointestinal infarctions (HP:0005244)3.14366070
42Pulmonary infiltrates (HP:0002113)3.13859801
43Recurrent otitis media (HP:0000403)3.10761618
44Hemoptysis (HP:0002105)3.00914789
45Lymphoma (HP:0002665)2.98230621
46Obstructive lung disease (HP:0006536)2.93287977
47Chronic obstructive pulmonary disease (HP:0006510)2.93287977
48Urticaria (HP:0001025)2.83478740
49Gangrene (HP:0100758)2.80272271
50Panhypogammaglobulinemia (HP:0003139)2.76562267
51Keratoconjunctivitis sicca (HP:0001097)2.71286266
52Abnormal pupillary function (HP:0007686)2.71249947
53Joint swelling (HP:0001386)2.68496881
54Agammaglobulinemia (HP:0004432)2.68125277
55Ureteral stenosis (HP:0000071)2.51788447
56Amyotrophic lateral sclerosis (HP:0007354)2.50009078
57Abnormality of male internal genitalia (HP:0000022)2.49374795
58Autoimmune thrombocytopenia (HP:0001973)2.49070802
59Hypergammaglobulinemia (HP:0010702)2.47269289
60Reduced subcutaneous adipose tissue (HP:0003758)2.46781394
61Keratoconjunctivitis (HP:0001096)2.43935005
62Arterial thrombosis (HP:0004420)2.43914971
63Emphysema (HP:0002097)2.43161688
64Thrombocytosis (HP:0001894)2.42773714
65Chronic otitis media (HP:0000389)2.39872499
66Recurrent skin infections (HP:0001581)2.37094183
67Pulmonary embolism (HP:0002204)2.35443991
68Basal cell carcinoma (HP:0002671)2.34979422
69Anorexia (HP:0002039)2.29933520
70Meningitis (HP:0001287)2.26720180
71Increased density of long bones (HP:0006392)2.25763504
72Abnormality of the prostate (HP:0008775)2.24545781
73Mediastinal lymphadenopathy (HP:0100721)2.24526743
74Abnormality of the phalanges of the 2nd finger (HP:0009541)2.24034016
75Ureteral obstruction (HP:0006000)2.23854829
76Restrictive lung disease (HP:0002091)2.23160456
77Ileus (HP:0002595)2.21638693
78Recurrent abscess formation (HP:0002722)2.17960668
79Muscle fiber atrophy (HP:0100295)2.15284778
80Progressive muscle weakness (HP:0003323)2.13174792
81Nasal polyposis (HP:0100582)2.11268030
82Microcytic anemia (HP:0001935)2.11185346
83Type 2 muscle fiber atrophy (HP:0003554)2.10663346
84Hypoplasia of the ulna (HP:0003022)2.10054633
85Mucosal telangiectasiae (HP:0100579)2.08990022
86Spontaneous hematomas (HP:0007420)2.08723250
87Verrucae (HP:0200043)2.08481328
88Papilloma (HP:0012740)2.08481328
89Fibular aplasia (HP:0002990)2.05811901
90Increased hepatocellular lipid droplets (HP:0006565)2.05389214
91Arthralgia (HP:0002829)2.04717680
92Recurrent viral infections (HP:0004429)2.01576230
93Chest pain (HP:0100749)2.00198294
94Gingivitis (HP:0000230)2.00087698
95Aplasia/Hypoplasia of the ulna (HP:0006495)1.99844031
96Deep philtrum (HP:0002002)1.98342930
97Abnormality of the fingertips (HP:0001211)1.94962161
98Limb hypertonia (HP:0002509)1.92824792
99Abnormality of the nasal mucosa (HP:0000433)1.89885108
100Recurrent pneumonia (HP:0006532)1.89532492
101Xerostomia (HP:0000217)1.89086666
102Colon cancer (HP:0003003)1.88766589
103Aplasia/Hypoplasia of the thymus (HP:0010515)1.87491591
104Poikiloderma (HP:0001029)1.87198977
105Pancytopenia (HP:0001876)1.86828288
106Pulmonary fibrosis (HP:0002206)1.85230484
107Cavernous hemangioma (HP:0001048)1.84616297
108Eosinophilia (HP:0001880)1.84540039
109Radial bowing (HP:0002986)1.83889297
110Bronchiectasis (HP:0002110)1.83826438
111Abnormality of the pleura (HP:0002103)1.83305168
112Encephalitis (HP:0002383)1.83169860
113Paralysis (HP:0003470)1.82352285
114Amaurosis fugax (HP:0100576)1.82257267
115Papilledema (HP:0001085)1.82022987
116Polyneuropathy (HP:0001271)1.81556663
117Skin rash (HP:0000988)1.80541312
118Decreased activity of mitochondrial respiratory chain (HP:0008972)1.79306824
119Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.79306824
120Seborrheic dermatitis (HP:0001051)1.76309074
121Abnormality of macrophages (HP:0004311)1.71211655
122Abnormality of the pericardium (HP:0001697)1.69856397
123Glomerulopathy (HP:0100820)1.67045091
124Premature skin wrinkling (HP:0100678)1.66614847
125Bicuspid aortic valve (HP:0001647)1.65716178
126Epistaxis (HP:0000421)1.62882763
127Skin ulcer (HP:0200042)1.61356462
128Granulocytopenia (HP:0001913)1.61116367
129Thrombophlebitis (HP:0004418)1.60573156

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK8.26124532
2TXK7.39598106
3MAP4K15.27275039
4BRD44.49572893
5KDR4.29534487
6ZAP704.23461549
7BLK3.76733093
8FGFR43.18056175
9TESK22.95991911
10ITK2.85687085
11JAK32.63095083
12IKBKE2.35195199
13JAK12.18852587
14TYK22.05542543
15STK42.05032368
16NME22.01941578
17PIK3CG2.00232553
18TBK11.98996461
19MAP3K141.94467010
20TNIK1.92066369
21MAP3K121.90556789
22SRPK11.88315502
23TEC1.80024734
24SYK1.78322765
25LCK1.77017156
26NME11.71638506
27BCR1.59462220
28FGFR31.58240662
29GRK61.43168612
30HCK1.38125986
31CSK1.32106111
32TESK11.26680274
33EIF2AK11.22965852
34STK101.19790685
35NLK1.17564136
36TAOK31.14165727
37CDK81.07614413
38FGFR10.99208677
39TRPM70.97823808
40BTK0.94454956
41IRAK40.89693531
42BMPR20.86322110
43ADRBK20.85893365
44PRKCQ0.85888908
45LYN0.84215176
46MAP2K60.83296837
47TGFBR20.82538080
48FGFR20.78855073
49IKBKB0.78801907
50NEK90.78174821
51LIMK10.77778014
52AKT30.77380164
53VRK20.71863406
54CSNK1A1L0.71268999
55LRRK20.70533847
56DAPK30.69257220
57JAK20.66339881
58TLK10.64446384
59TRIM280.64226708
60RIPK40.64136941
61KIT0.63802003
62SIK30.62369634
63CHUK0.61958001
64SCYL20.61941164
65PRKCH0.61118729
66FYN0.60639119
67CSNK1G30.60027311
68VRK10.58453206
69STK38L0.57587400
70EEF2K0.57280261
71SIK10.56336016
72ERN10.55659680
73CLK10.55301574
74ERBB30.55046358
75TYRO30.53993195
76ILK0.51457375
77TAOK10.49653946
78INSR0.49578693
79EPHA30.48585220
80CSF1R0.48477379
81MKNK20.48158410
82GRK70.46097884
83IRAK10.45875596
84NTRK20.45522141
85TSSK60.45174248
86CSNK1G10.45108013
87ALK0.44604119
88SIK20.42799000
89PDK10.41944174
90MAP3K70.41941998
91PASK0.41748629
92PDGFRB0.41582078
93TGFBR10.40631078
94IGF1R0.39282726
95MAP3K110.38807301
96CSNK1G20.38137921
97MYLK0.37995830
98EIF2AK30.37638358
99WNK10.35453230
100MAP3K130.33317516
101FES0.33286001
102IRAK20.32768069
103ACVR1B0.32684106
104TNK20.31551680
105CAMKK20.30543890
106RPS6KA50.30438823
107MST40.29618969
108CDK60.28779590
109BUB10.27261083
110CDK40.27037186
111GSK3A0.26332462
112PIM20.26233217
113HIPK20.24286083
114PIM10.24071764
115GRK10.23952014
116ROCK20.22955449
117RPS6KB10.22731012
118ROCK10.22178202
119MAPK110.22025431
120MAP3K100.21803523
121EIF2AK20.21501978
122STK30.21280534
123EPHB10.20951867
124RPS6KA40.20315862
125MAPK30.19136633
126STK390.18499179
127PRKCD0.18089489
128MAPK90.16921398
129SRC0.15678148
130NUAK10.15340573
131STK240.14807821
132PAK30.14692171
133ABL10.14476440
134TRIB30.13748773
135MARK30.13631692
136FGR0.12609997
137MAPKAPK20.11581224
138MELK0.10430865
139MKNK10.09351424
140EGFR0.09234382
141MAP3K50.08865036
142RPS6KA10.07333003

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053406.96214387
2Intestinal immune network for IgA production_Homo sapiens_hsa046724.40137700
3T cell receptor signaling pathway_Homo sapiens_hsa046604.34662157
4Allograft rejection_Homo sapiens_hsa053304.00680883
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.80633389
6Asthma_Homo sapiens_hsa053103.63772606
7Autoimmune thyroid disease_Homo sapiens_hsa053203.52202905
8Measles_Homo sapiens_hsa051622.80022621
9Hematopoietic cell lineage_Homo sapiens_hsa046402.79598331
10Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.78956666
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.29553609
12Antigen processing and presentation_Homo sapiens_hsa046121.94831565
13Viral myocarditis_Homo sapiens_hsa054161.79294555
14Leishmaniasis_Homo sapiens_hsa051401.78812870
15Jak-STAT signaling pathway_Homo sapiens_hsa046301.73859994
16Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.70028058
17Proteasome_Homo sapiens_hsa030501.67390533
18Graft-versus-host disease_Homo sapiens_hsa053321.64724394
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62536567
20Osteoclast differentiation_Homo sapiens_hsa043801.51258413
21* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40544270
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39435320
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27988829
24Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21002451
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18121843
26Herpes simplex infection_Homo sapiens_hsa051681.13339303
27HTLV-I infection_Homo sapiens_hsa051661.03757610
28Malaria_Homo sapiens_hsa051440.97566515
29Toxoplasmosis_Homo sapiens_hsa051450.95083715
30B cell receptor signaling pathway_Homo sapiens_hsa046620.94341891
31Shigellosis_Homo sapiens_hsa051310.93151454
32Systemic lupus erythematosus_Homo sapiens_hsa053220.92520168
33RNA polymerase_Homo sapiens_hsa030200.92368138
34Other glycan degradation_Homo sapiens_hsa005110.91491510
35Epstein-Barr virus infection_Homo sapiens_hsa051690.86673937
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85479169
37Apoptosis_Homo sapiens_hsa042100.85248257
38Leukocyte transendothelial migration_Homo sapiens_hsa046700.82555546
39Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.82212657
40Ribosome_Homo sapiens_hsa030100.81464047
41Type I diabetes mellitus_Homo sapiens_hsa049400.79247005
42* Chemokine signaling pathway_Homo sapiens_hsa040620.77490464
43Hepatitis B_Homo sapiens_hsa051610.75563889
44Pancreatic cancer_Homo sapiens_hsa052120.71537700
45Staphylococcus aureus infection_Homo sapiens_hsa051500.70595759
46TNF signaling pathway_Homo sapiens_hsa046680.63363419
47Spliceosome_Homo sapiens_hsa030400.63027439
48VEGF signaling pathway_Homo sapiens_hsa043700.61529134
49* Viral carcinogenesis_Homo sapiens_hsa052030.58443503
50NOD-like receptor signaling pathway_Homo sapiens_hsa046210.57509596
51Hepatitis C_Homo sapiens_hsa051600.57172637
52Sulfur relay system_Homo sapiens_hsa041220.55483957
53Prolactin signaling pathway_Homo sapiens_hsa049170.55283582
54Nucleotide excision repair_Homo sapiens_hsa034200.54458217
55DNA replication_Homo sapiens_hsa030300.53210788
56Acute myeloid leukemia_Homo sapiens_hsa052210.53164034
57Salmonella infection_Homo sapiens_hsa051320.53159732
58Tuberculosis_Homo sapiens_hsa051520.51136074
59Mismatch repair_Homo sapiens_hsa034300.50685877
60Influenza A_Homo sapiens_hsa051640.48232475
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46123810
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.45133936
63Legionellosis_Homo sapiens_hsa051340.43293118
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42997977
65p53 signaling pathway_Homo sapiens_hsa041150.42033181
66Protein export_Homo sapiens_hsa030600.40658364
67RNA degradation_Homo sapiens_hsa030180.39994029
68RNA transport_Homo sapiens_hsa030130.39366898
69Adipocytokine signaling pathway_Homo sapiens_hsa049200.37616758
70Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37306395
71Colorectal cancer_Homo sapiens_hsa052100.36357035
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.33302709
73Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32168240
74Platelet activation_Homo sapiens_hsa046110.31307347
75Base excision repair_Homo sapiens_hsa034100.30533451
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30386784
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27793812
78AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.26999541
79Circadian rhythm_Homo sapiens_hsa047100.26849139
80Rheumatoid arthritis_Homo sapiens_hsa053230.26823212
81Notch signaling pathway_Homo sapiens_hsa043300.26593846
82Endocytosis_Homo sapiens_hsa041440.24565452
83Pentose phosphate pathway_Homo sapiens_hsa000300.24015456
84Pyrimidine metabolism_Homo sapiens_hsa002400.24001072
85Rap1 signaling pathway_Homo sapiens_hsa040150.23160656
86mRNA surveillance pathway_Homo sapiens_hsa030150.20144036
87Vitamin B6 metabolism_Homo sapiens_hsa007500.19194397
88Fanconi anemia pathway_Homo sapiens_hsa034600.18111083
89Chronic myeloid leukemia_Homo sapiens_hsa052200.17984020
90Basal transcription factors_Homo sapiens_hsa030220.17799152
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.16402869
92Pertussis_Homo sapiens_hsa051330.15691126
93Inositol phosphate metabolism_Homo sapiens_hsa005620.15331828
94Homologous recombination_Homo sapiens_hsa034400.14838924
95Small cell lung cancer_Homo sapiens_hsa052220.14804911
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.13647023
97Alcoholism_Homo sapiens_hsa050340.13279926
98Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.11532470
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.10701620
100Lysosome_Homo sapiens_hsa041420.10594881
101Purine metabolism_Homo sapiens_hsa002300.09606831
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.09519747
103African trypanosomiasis_Homo sapiens_hsa051430.08876696
104MAPK signaling pathway_Homo sapiens_hsa040100.08673572
105FoxO signaling pathway_Homo sapiens_hsa040680.07102055
106Thyroid cancer_Homo sapiens_hsa052160.05777388
107Non-homologous end-joining_Homo sapiens_hsa034500.05641262
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.05599358
109Non-small cell lung cancer_Homo sapiens_hsa052230.05587631
110Caffeine metabolism_Homo sapiens_hsa002320.05424228
111Peroxisome_Homo sapiens_hsa041460.05284641
112Prostate cancer_Homo sapiens_hsa052150.03067052
113Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.02979932
114Neurotrophin signaling pathway_Homo sapiens_hsa047220.02954023
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.02182180
116Steroid biosynthesis_Homo sapiens_hsa001000.02096729
117Dorso-ventral axis formation_Homo sapiens_hsa043200.00587728
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.00420762
119Cell cycle_Homo sapiens_hsa04110-0.0258866
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750-0.0079905

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