CCR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.72161412
2neutrophil activation involved in immune response (GO:0002283)6.59606901
3response to peptidoglycan (GO:0032494)5.85167148
4positive regulation by symbiont of host defense response (GO:0052509)5.62033557
5modulation by symbiont of host defense response (GO:0052031)5.62033557
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.62033557
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.62033557
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.62033557
9modulation by symbiont of host immune response (GO:0052553)5.62033557
10positive regulation of gamma-delta T cell activation (GO:0046645)5.39550828
11negative regulation of cell killing (GO:0031342)5.12448714
12negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.12448714
13production of molecular mediator involved in inflammatory response (GO:0002532)5.06799671
14respiratory burst (GO:0045730)4.99978951
15macrophage activation involved in immune response (GO:0002281)4.84094340
16cellular extravasation (GO:0045123)4.71417352
17granulocyte activation (GO:0036230)4.64470363
18regulation of interferon-beta biosynthetic process (GO:0045357)4.41593228
19positive regulation of mast cell activation (GO:0033005)4.39273721
20neutrophil activation (GO:0042119)4.31806131
21positive regulation of mast cell activation involved in immune response (GO:0033008)4.28022002
22positive regulation of mast cell degranulation (GO:0043306)4.28022002
23superoxide anion generation (GO:0042554)4.16658359
24detection of bacterium (GO:0016045)4.16295930
25hydrogen peroxide biosynthetic process (GO:0050665)4.11566415
26immunoglobulin mediated immune response (GO:0016064)4.11020379
27response to host immune response (GO:0052572)4.08972565
28response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.08972565
29regulation of mast cell degranulation (GO:0043304)4.05518917
30myeloid cell activation involved in immune response (GO:0002275)4.04177434
31regulation of B cell receptor signaling pathway (GO:0050855)4.01131251
32positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.01056640
33regulation of mast cell activation (GO:0033003)3.94899784
34lipopolysaccharide-mediated signaling pathway (GO:0031663)3.93929634
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.92176756
36positive regulation of interferon-alpha production (GO:0032727)3.90090491
37leukocyte aggregation (GO:0070486)3.87651917
38regulation of gamma-delta T cell activation (GO:0046643)3.83084653
39eosinophil chemotaxis (GO:0048245)3.81016716
40detection of biotic stimulus (GO:0009595)3.80588138
41positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.79382860
42regulation of mast cell activation involved in immune response (GO:0033006)3.79173263
43microglial cell activation (GO:0001774)3.71538562
44macrophage activation (GO:0042116)3.70158259
45regulation of interferon-alpha production (GO:0032647)3.68809312
46detection of molecule of bacterial origin (GO:0032490)3.66858189
47reactive oxygen species biosynthetic process (GO:1903409)3.66337360
48positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.64633312
49positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.64185299
50response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.62439299
51response to host (GO:0075136)3.62439299
52response to host defenses (GO:0052200)3.62439299
53neutrophil chemotaxis (GO:0030593)3.62338875
54eosinophil migration (GO:0072677)3.60767765
55regulation of T-helper 1 cell differentiation (GO:0045625)3.57167504
56positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.57084888
57antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.56940955
58regulation of myeloid leukocyte mediated immunity (GO:0002886)3.54268212
59neutrophil migration (GO:1990266)3.52509920
60positive regulation of cellular amide metabolic process (GO:0034250)3.49982114
61regulation of leukocyte degranulation (GO:0043300)3.48225675
62regulation of mononuclear cell migration (GO:0071675)3.44572236
63negative regulation of interleukin-17 production (GO:0032700)3.43481732
64positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.43254829
65positive regulation of antigen processing and presentation (GO:0002579)3.43198394
66interferon-gamma-mediated signaling pathway (GO:0060333)3.37819465
67response to muramyl dipeptide (GO:0032495)3.37126496
68negative regulation of mast cell activation (GO:0033004)3.33035103
69neutrophil mediated immunity (GO:0002446)3.32851810
70granulocyte chemotaxis (GO:0071621)3.32654042
71positive regulation of macrophage cytokine production (GO:0060907)3.32178111
72positive regulation of leukocyte degranulation (GO:0043302)3.31583990
73regulation of T cell tolerance induction (GO:0002664)3.30315363
74regulation of dendritic cell antigen processing and presentation (GO:0002604)3.28784969
75positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.28719887
76negative regulation of lymphocyte mediated immunity (GO:0002707)3.28294411
77positive regulation of chemokine biosynthetic process (GO:0045080)3.25851728
78* positive regulation of monocyte chemotaxis (GO:0090026)3.23847191
79phagosome maturation (GO:0090382)3.23196586
80granulocyte migration (GO:0097530)3.22323883
81regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.21205034
82positive regulation of lymphocyte migration (GO:2000403)3.20521324
83response to type I interferon (GO:0034340)3.19741435
84regulation of tolerance induction (GO:0002643)3.19064960
85regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.18988553
86cellular response to thyroid hormone stimulus (GO:0097067)3.17980228
87lymphocyte chemotaxis (GO:0048247)3.16742082
88negative regulation of leukocyte mediated immunity (GO:0002704)3.15832322
89positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.13964662
90positive regulation of tumor necrosis factor production (GO:0032760)3.13228601
91amino sugar catabolic process (GO:0046348)3.12409329
92leukocyte mediated cytotoxicity (GO:0001909)3.12215685
93regulation of lymphocyte chemotaxis (GO:1901623)3.11481115
94germinal center formation (GO:0002467)3.10869447
95detection of other organism (GO:0098543)3.10135284
96negative regulation of erythrocyte differentiation (GO:0045647)3.10098759
97myeloid leukocyte activation (GO:0002274)3.06793586
98glycosphingolipid catabolic process (GO:0046479)3.06054655
99defense response to protozoan (GO:0042832)3.05079532
100negative regulation of T cell mediated immunity (GO:0002710)3.04105882
101lipoxygenase pathway (GO:0019372)3.03012194
102leukocyte migration involved in inflammatory response (GO:0002523)3.02570141
103monocyte chemotaxis (GO:0002548)3.01827419
104negative regulation of interleukin-12 production (GO:0032695)3.01656991
105regulation of gamma-delta T cell differentiation (GO:0045586)3.01537759
106myeloid dendritic cell differentiation (GO:0043011)3.00077976
107T-helper 1 type immune response (GO:0042088)2.99518689
108positive regulation of macrophage differentiation (GO:0045651)2.98705822
109regulation of antigen processing and presentation (GO:0002577)2.98531379
110regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.98322070
111regulation of T-helper 2 cell differentiation (GO:0045628)2.94937028
112B cell mediated immunity (GO:0019724)2.94865248
113negative regulation of cytokine production involved in immune response (GO:0002719)2.94829709
114I-kappaB phosphorylation (GO:0007252)2.94576167
115detection of external biotic stimulus (GO:0098581)2.93042386
116positive regulation of type 2 immune response (GO:0002830)2.92171020
117response to fungus (GO:0009620)2.89755797
118T cell migration (GO:0072678)2.89281319
119myeloid leukocyte mediated immunity (GO:0002444)2.88482136
120positive regulation of toll-like receptor signaling pathway (GO:0034123)2.87480565
121positive regulation of interferon-beta production (GO:0032728)2.87474662
122oligosaccharide catabolic process (GO:0009313)2.86990853
123positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.86211440
124regulation of lymphocyte migration (GO:2000401)2.85907866
125myeloid dendritic cell activation (GO:0001773)2.85335739
126regulation of regulated secretory pathway (GO:1903305)2.84332215
127leukocyte degranulation (GO:0043299)2.83086397
128positive regulation of B cell differentiation (GO:0045579)2.80729789
129antigen processing and presentation of endogenous antigen (GO:0019883)2.80722903
130type I interferon signaling pathway (GO:0060337)2.80450916
131cellular response to type I interferon (GO:0071357)2.80450916
132regulation of interleukin-8 biosynthetic process (GO:0045414)2.79894067

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human9.91726403
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.02264737
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.71446619
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.58435166
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.27094473
6NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.85629075
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.83274572
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.43568677
9MYB_21317192_ChIP-Seq_ERMYB_Mouse3.37163929
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.23420040
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.98410350
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.98338414
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.88242447
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.73685408
15NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.68101789
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.66711796
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.50709000
18* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.43190415
19BRD4_27068464_Chip-Seq_AML-cells_Mouse2.29821488
20STAT4_19710469_ChIP-ChIP_TH1__Mouse2.24174315
21* SPI1_23547873_ChIP-Seq_NB4_Human2.17084928
22PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.03371364
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.87772574
24* VDR_24787735_ChIP-Seq_THP-1_Human1.82321855
25CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.75797183
26* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.74302542
27PU_27001747_Chip-Seq_BMDM_Mouse1.72598645
28STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.72221446
29* VDR_24763502_ChIP-Seq_THP-1_Human1.71466846
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.68517526
31* RUNX1_22412390_ChIP-Seq_EML_Mouse1.67764978
32RUNX_20019798_ChIP-Seq_JUKART_Human1.67742949
33* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.66441424
34SCL_19346495_ChIP-Seq_HPC-7_Human1.63900401
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61841556
36SPI1_23127762_ChIP-Seq_K562_Human1.57830479
37MYB_26560356_Chip-Seq_TH2_Human1.56771918
38GATA1_22025678_ChIP-Seq_K562_Human1.55157046
39MYC_22102868_ChIP-Seq_BL_Human1.51107001
40CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.50090463
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48210179
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47096841
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46398096
44* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.45200928
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43235381
46* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34943818
47MAF_26560356_Chip-Seq_TH2_Human1.32468937
48KDM2B_26808549_Chip-Seq_DND41_Human1.31945286
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28423157
50* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27509383
51MAF_26560356_Chip-Seq_TH1_Human1.24975215
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.22339248
53STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22163394
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.21680120
55EGR1_19032775_ChIP-ChIP_M12_Human1.19621843
56PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19485622
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19295173
58LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16538895
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15843440
60SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15245068
61* LXR_22292898_ChIP-Seq_THP-1_Human1.15082293
62SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13479822
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12600624
64KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12386201
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.12272327
66VDR_21846776_ChIP-Seq_THP-1_Human1.10849101
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.08542056
68MYB_26560356_Chip-Seq_TH1_Human1.07329326
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06174227
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05328352
71TFEB_21752829_ChIP-Seq_HELA_Human1.03701876
72GATA3_26560356_Chip-Seq_TH2_Human1.03429176
73TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03001032
74GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02987651
75GATA3_27048872_Chip-Seq_THYMUS_Human1.01872902
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01208830
77CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99549463
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99092597
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97294725
80GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93917705
81TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92108559
82PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92009611
83NRF2_20460467_ChIP-Seq_MEFs_Mouse0.90650726
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.90650726
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88341029
86UTX_26944678_Chip-Seq_JUKART_Human0.88247274
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87746828
88BCL6_27268052_Chip-Seq_Bcells_Human0.85349791
89VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.82491586
90KDM2B_26808549_Chip-Seq_JURKAT_Human0.80953846
91BCOR_27268052_Chip-Seq_Bcells_Human0.79254369
92SOX2_20726797_ChIP-Seq_SW620_Human0.78323760
93GATA2_19941826_ChIP-Seq_K562_Human0.76545484
94RARG_19884340_ChIP-ChIP_MEFs_Mouse0.76033233
95CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.75948516
96NCOR1_26117541_ChIP-Seq_K562_Human0.75717645
97STAT1_20625510_ChIP-Seq_HELA_Human0.75376431
98RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74689922
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.74682052
100TP63_17297297_ChIP-ChIP_HaCaT_Human0.74432553
101GATA1_19941827_ChIP-Seq_MEL_Mouse0.74305752
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.73721865
103RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73580592
104* SPI1_20517297_ChIP-Seq_HL60_Human0.71734214
105* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.71562897
106TCF7_22412390_ChIP-Seq_EML_Mouse0.71268549
107FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.70020005
108P63_26484246_Chip-Seq_KERATINOCYTES_Human0.67782464
109KDM2B_26808549_Chip-Seq_K562_Human0.66799380
110JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.65988227
111CJUN_26792858_Chip-Seq_BT549_Human0.65771796
112ELK3_25401928_ChIP-Seq_HUVEC_Human0.65620315
113GATA1_19941826_ChIP-Seq_K562_Human0.64159915
114JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.63839949
115RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.62512866
116GATA1_22383799_ChIP-Seq_G1ME_Mouse0.62317965
117SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.61807245
118SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.61807245
119CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.61797321
120ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.61518622
121* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.61203604
122* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.58640237
123SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.56736086

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.79603251
2MP0001835_abnormal_antigen_presentation4.65400715
3MP0003303_peritoneal_inflammation3.81521386
4* MP0002148_abnormal_hypersensitivity_rea3.75855379
5MP0009785_altered_susceptibility_to3.67972160
6* MP0002419_abnormal_innate_immunity3.55039014
7MP0005000_abnormal_immune_tolerance3.38959326
8MP0006082_CNS_inflammation3.33095061
9MP0003724_increased_susceptibility_to3.21849966
10* MP0005025_abnormal_response_to3.07568622
11MP0005058_abnormal_lysosome_morphology2.71710688
12MP0002452_abnormal_antigen_presenting2.66888540
13MP0001533_abnormal_skeleton_physiology2.55276384
14MP0001790_abnormal_immune_system2.47480752
15MP0005387_immune_system_phenotype2.47480752
16MP0005671_abnormal_response_to2.40957811
17* MP0002723_abnormal_immune_serum2.40807977
18MP0001800_abnormal_humoral_immune2.36940623
19MP0001853_heart_inflammation2.34831679
20MP0005464_abnormal_platelet_physiology2.27157721
21MP0001819_abnormal_immune_cell2.23809915
22MP0002420_abnormal_adaptive_immunity2.21563843
23MP0009764_decreased_sensitivity_to2.14220254
24MP0004510_myositis2.13416011
25MP0003075_altered_response_to2.12639956
26MP0000685_abnormal_immune_system2.08744942
27* MP0000343_altered_response_to2.05893130
28MP0003191_abnormal_cellular_cholesterol1.97750949
29MP0003448_altered_tumor_morphology1.95491506
30* MP0001845_abnormal_inflammatory_respons1.92417620
31* MP0002405_respiratory_system_inflammati1.91960106
32MP0003172_abnormal_lysosome_physiology1.82216612
33MP0003690_abnormal_glial_cell1.81024560
34MP0005166_decreased_susceptibility_to1.77692936
35MP0005451_abnormal_body_composition1.77268539
36MP0000604_amyloidosis1.76941669
37MP0009278_abnormal_bone_marrow1.74774417
38MP0009840_abnormal_foam_cell1.69588243
39MP0004947_skin_inflammation1.67015164
40MP0008469_abnormal_protein_level1.63973792
41MP0003828_pulmonary_edema1.63844480
42MP0010155_abnormal_intestine_physiology1.62609303
43MP0009333_abnormal_splenocyte_physiolog1.50547279
44MP0005164_abnormal_response_to1.47945607
45MP0005310_abnormal_salivary_gland1.46133785
46MP0002998_abnormal_bone_remodeling1.46094433
47MP0005167_abnormal_blood-brain_barrier1.43724209
48* MP0000716_abnormal_immune_system1.43474169
49MP0000858_altered_metastatic_potential1.39237227
50MP0003300_gastrointestinal_ulcer1.32995006
51MP0002398_abnormal_bone_marrow1.27315592
52MP0004883_abnormal_blood_vessel1.26573529
53MP0005390_skeleton_phenotype1.22146885
54MP0003763_abnormal_thymus_physiology1.19649771
55MP0002138_abnormal_hepatobiliary_system1.19309176
56MP0002933_joint_inflammation1.17761685
57MP0000569_abnormal_digit_pigmentation1.17056692
58MP0003183_abnormal_peptide_metabolism1.16461345
59MP0001851_eye_inflammation1.15350396
60MP0002006_tumorigenesis1.12963189
61* MP0002429_abnormal_blood_cell1.12847828
62MP0004782_abnormal_surfactant_physiolog1.12274597
63MP0005174_abnormal_tail_pigmentation1.10121934
64MP0000689_abnormal_spleen_morphology1.10076600
65MP0003806_abnormal_nucleotide_metabolis1.09022530
66MP0005397_hematopoietic_system_phenotyp1.08657115
67MP0001545_abnormal_hematopoietic_system1.08657115
68MP0002132_abnormal_respiratory_system1.07372379
69MP0002277_abnormal_respiratory_mucosa1.04093200
70MP0003329_amyloid_beta_deposits1.02341660
71MP0000465_gastrointestinal_hemorrhage0.99128703
72MP0002722_abnormal_immune_system0.97287847
73MP0002139_abnormal_hepatobiliary_system0.96701464
74MP0009763_increased_sensitivity_to0.95287216
75MP0003186_abnormal_redox_activity0.94402374
76MP0003279_aneurysm0.92212272
77MP0000920_abnormal_myelination0.90746165
78MP0005076_abnormal_cell_differentiation0.88095796
79MP0000249_abnormal_blood_vessel0.87777941
80MP0000703_abnormal_thymus_morphology0.80181837
81MP0003453_abnormal_keratinocyte_physiol0.77860917
82MP0003795_abnormal_bone_structure0.75399482
83MP0003566_abnormal_cell_adhesion0.74728391
84MP0003656_abnormal_erythrocyte_physiolo0.73235624
85MP0001663_abnormal_digestive_system0.72925729
86MP0008260_abnormal_autophagy0.71796844
87MP0009765_abnormal_xenobiotic_induced0.69980293
88MP0002877_abnormal_melanocyte_morpholog0.68396621
89MP0003091_abnormal_cell_migration0.67375359
90MP0004381_abnormal_hair_follicle0.66829971
91MP0008874_decreased_physiological_sensi0.66662683
92MP0002254_reproductive_system_inflammat0.65544642
93MP0005023_abnormal_wound_healing0.65410443
94MP0000015_abnormal_ear_pigmentation0.62963232
95MP0002166_altered_tumor_susceptibility0.62796517
96MP0000371_diluted_coat_color0.62329760
97MP0010307_abnormal_tumor_latency0.61779290
98MP0010352_gastrointestinal_tract_polyps0.60272092
99MP0000490_abnormal_crypts_of0.59343967
100MP0002332_abnormal_exercise_endurance0.59136467
101MP0004808_abnormal_hematopoietic_stem0.58617558
102MP0003221_abnormal_cardiomyocyte_apopto0.58502499
103MP0003045_fibrosis0.57253037
104MP0008438_abnormal_cutaneous_collagen0.57180117
105MP0002136_abnormal_kidney_physiology0.56963193
106MP0003866_abnormal_defecation0.56545182
107MP0005319_abnormal_enzyme/_coenzyme0.55090036
108MP0002396_abnormal_hematopoietic_system0.54100640
109MP0008004_abnormal_stomach_pH0.52952241
110MP0000609_abnormal_liver_physiology0.52345929
111MP0005165_increased_susceptibility_to0.51530201
112MP0000767_abnormal_smooth_muscle0.49776715
113MP0006054_spinal_hemorrhage0.49018936
114MP0003705_abnormal_hypodermis_morpholog0.47659078
115MP0003638_abnormal_response/metabolism_0.46294908
116MP0009115_abnormal_fat_cell0.45489393
117MP0008873_increased_physiological_sensi0.45392411

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)8.61937338
2Eczematoid dermatitis (HP:0000976)8.10378930
3Recurrent bacterial skin infections (HP:0005406)7.64142011
4Recurrent gram-negative bacterial infections (HP:0005420)7.48112379
5Abnormality of macrophages (HP:0004311)5.64930726
6Systemic lupus erythematosus (HP:0002725)5.26308675
7Mediastinal lymphadenopathy (HP:0100721)5.14429166
8Vacuolated lymphocytes (HP:0001922)4.79323428
9Recurrent skin infections (HP:0001581)4.75909045
10Gingivitis (HP:0000230)4.73424325
11Chronic obstructive pulmonary disease (HP:0006510)4.65769239
12Obstructive lung disease (HP:0006536)4.65769239
13Stomatitis (HP:0010280)4.47782029
14Increased cerebral lipofuscin (HP:0011813)4.07975803
15Recurrent fungal infections (HP:0002841)4.04665082
16Myositis (HP:0100614)3.93636284
17Increased neuronal autofluorescent lipopigment (HP:0002074)3.92848675
18Orchitis (HP:0100796)3.90015917
19Prostate neoplasm (HP:0100787)3.82654367
20Axonal loss (HP:0003447)3.81837435
21Disinhibition (HP:0000734)3.68364471
22Optic neuritis (HP:0100653)3.66944670
23Retrobulbar optic neuritis (HP:0100654)3.66944670
24Autoimmune thrombocytopenia (HP:0001973)3.60536729
25Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.58771399
26Elevated erythrocyte sedimentation rate (HP:0003565)3.44370248
27Recurrent cutaneous fungal infections (HP:0011370)3.40619364
28Chronic mucocutaneous candidiasis (HP:0002728)3.40619364
29Glomerulonephritis (HP:0000099)3.31058756
30Cellulitis (HP:0100658)3.29914792
31Urticaria (HP:0001025)3.26376468
32Pustule (HP:0200039)3.24277837
33Thick nail (HP:0001805)3.14343018
34Agnosia (HP:0010524)3.11872235
35Interstitial pulmonary disease (HP:0006530)3.10064875
36Gastrointestinal infarctions (HP:0005244)3.06293601
37Abnormality of liposaccharide metabolism (HP:0010968)3.05498593
38Abnormality of glycosphingolipid metabolism (HP:0004343)3.05498593
39Abnormality of glycolipid metabolism (HP:0010969)3.05498593
40Periodontitis (HP:0000704)3.05277628
41Joint hemorrhage (HP:0005261)3.03931689
42Dysostosis multiplex (HP:0000943)3.01774101
43Amyloidosis (HP:0011034)2.96643326
44Meningitis (HP:0001287)2.87644340
45Encephalitis (HP:0002383)2.85472426
46Basal ganglia calcification (HP:0002135)2.82918145
47T lymphocytopenia (HP:0005403)2.82248728
48Recurrent viral infections (HP:0004429)2.75620954
49Vasculitis (HP:0002633)2.75005099
50Mutism (HP:0002300)2.74026653
51Spontaneous hematomas (HP:0007420)2.71788286
52Abnormal delayed hypersensitivity skin test (HP:0002963)2.61767884
53Hepatosplenomegaly (HP:0001433)2.61173462
54Osteomyelitis (HP:0002754)2.59169346
55Myocardial infarction (HP:0001658)2.55894302
56Pulmonary infiltrates (HP:0002113)2.55539085
57Petechiae (HP:0000967)2.52162330
58Recurrent pneumonia (HP:0006532)2.51804563
59Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.48169792
60Chest pain (HP:0100749)2.45139477
61Hemoptysis (HP:0002105)2.41939723
62Abnormality of complement system (HP:0005339)2.41675966
63Hematochezia (HP:0002573)2.39900954
64Increased serum ferritin (HP:0003281)2.36722980
65Arterial thrombosis (HP:0004420)2.32763723
66Keratoconjunctivitis sicca (HP:0001097)2.32223456
67Pulmonary embolism (HP:0002204)2.31721188
68Increased IgE level (HP:0003212)2.30215323
69Abnormality of the prostate (HP:0008775)2.29704636
70Nephritis (HP:0000123)2.29117253
71Episodic fever (HP:0001954)2.28641790
72Leukocytosis (HP:0001974)2.27904465
73Neurofibrillary tangles (HP:0002185)2.27719557
74Upper motor neuron abnormality (HP:0002127)2.27481523
75Purpura (HP:0000979)2.23460926
76Neuronal loss in central nervous system (HP:0002529)2.22662540
77Gingival bleeding (HP:0000225)2.22652273
78Polyneuropathy (HP:0001271)2.20750343
79Cheilitis (HP:0100825)2.20162922
80Gangrene (HP:0100758)2.19185913
81Osteolytic defects of the hand bones (HP:0009699)2.18958397
82Osteolytic defects of the phalanges of the hand (HP:0009771)2.18958397
83Poor head control (HP:0002421)2.17287625
84Urinary glycosaminoglycan excretion (HP:0003541)2.16426380
85Mucopolysacchariduria (HP:0008155)2.16426380
86Recurrent lower respiratory tract infections (HP:0002783)2.16287989
87Pathologic fracture (HP:0002756)2.11184843
88Keratoconjunctivitis (HP:0001096)2.09953185
89Premature loss of primary teeth (HP:0006323)2.09788724
90Sepsis (HP:0100806)2.08953803
91Increased IgM level (HP:0003496)2.07138061
92Inflammation of the large intestine (HP:0002037)2.03355961
93Skin ulcer (HP:0200042)2.02200116
94Abnormality of iron homeostasis (HP:0011031)2.01535800
95Complement deficiency (HP:0004431)2.00935457
96Progressive neurologic deterioration (HP:0002344)2.00096832
97Abnormality of the pleura (HP:0002103)1.98628729
98Colitis (HP:0002583)1.98144717
99Vertigo (HP:0002321)1.97600199
100Abnormality of T cells (HP:0002843)1.97483121
101Hypergammaglobulinemia (HP:0010702)1.95815951
102Abnormality of the endocardium (HP:0004306)1.95712748
103Epistaxis (HP:0000421)1.95462353
104Abnormality of glycosaminoglycan metabolism (HP:0004371)1.95293528
105Abnormality of mucopolysaccharide metabolism (HP:0011020)1.95293528
106Abnormality of polysaccharide metabolism (HP:0011012)1.95293528
107Progressive visual loss (HP:0000529)1.94930494
108Apathy (HP:0000741)1.92198309
109Glomerulopathy (HP:0100820)1.92195090
110Loss of speech (HP:0002371)1.91723828
111Increased CSF protein (HP:0002922)1.90577893
112Abnormality of the pericardium (HP:0001697)1.89602558
113Menorrhagia (HP:0000132)1.88125469
114Anorexia (HP:0002039)1.85357657
115Chronic otitis media (HP:0000389)1.85119142
116Amaurosis fugax (HP:0100576)1.85091154
117Peritonitis (HP:0002586)1.84643342
118Bone pain (HP:0002653)1.82839842
119Restrictive lung disease (HP:0002091)1.82062786
120Gastrointestinal inflammation (HP:0004386)1.80994180
121Neoplasm of head and neck (HP:0012288)1.77944378
122Esophageal neoplasm (HP:0100751)1.77944378
123Prolonged bleeding time (HP:0003010)1.77508563
124J-shaped sella turcica (HP:0002680)1.76881380
125Abnormality of the vasculature of the conjunctiva (HP:0008054)1.75477010
126Inappropriate behavior (HP:0000719)1.73210593
127Diminished motivation (HP:0000745)1.73207090
128Abnormality of T cell number (HP:0011839)1.71111639

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK5.19584978
2RIPK43.92069100
3MAP3K143.35952488
4IRAK43.14096455
5PBK3.00515374
6IRAK32.92923351
7MAP4K12.87621562
8TYK22.72543548
9TBK12.67299650
10MST42.55676237
11TXK2.52883323
12PRPF4B2.38562782
13ERN11.92670486
14KIT1.89214560
15CSK1.82950380
16PIM21.81572109
17IKBKB1.79358767
18ZAP701.76171977
19FGR1.73087512
20EPHB11.73063649
21GRK71.71167620
22IKBKE1.64759148
23HCK1.63668166
24JAK11.62965029
25BTK1.62312245
26TAOK11.60671850
27SYK1.55688158
28JAK31.54263392
29FES1.49606528
30BMX1.47704466
31MST1R1.47447489
32NEK91.47332018
33TEC1.47067997
34TGFBR21.38948257
35LYN1.37966545
36CLK11.37763510
37STK101.35833172
38TAOK31.29650584
39TRPM71.28891768
40ABL21.22328240
41CSF1R1.19360777
42PIM11.15026444
43ACVR1B1.08797132
44MATK1.08549350
45KSR21.07615916
46LCK1.05721547
47MAP3K131.05500537
48JAK21.05398733
49ITK1.04227161
50IRAK21.01623258
51CDC42BPA1.01319771
52TESK20.93013261
53SIK30.92988866
54ADRBK20.92364965
55ARAF0.90834391
56ERBB30.90757199
57CAMKK20.90232894
58PRKCD0.88089661
59YES10.85878444
60MAP2K30.83929723
61BMPR20.83039068
62CHUK0.82888247
63LRRK20.81772440
64GRK60.81759495
65MARK30.80774575
66NME20.78611333
67DDR20.76284641
68DMPK0.75350507
69ABL10.74384447
70RPS6KA40.71743191
71MAP3K30.69328217
72MARK20.67930248
73MAPK120.67147418
74EIF2AK20.66673123
75EGFR0.65350190
76STK40.64096588
77MAPK70.63016786
78MOS0.61767380
79MAP3K20.60865761
80TRIB30.60629638
81MAP3K60.58385734
82RIPK10.58002028
83PAK40.56941477
84MAP2K60.55428759
85DAPK20.54388953
86TTN0.52562765
87FYN0.51967767
88PDK20.51357272
89FGFR30.50896748
90PIK3CG0.50592123
91PRKD20.49950525
92EPHA30.48831643
93MAP3K120.47521908
94SGK30.46810386
95KSR10.46581445
96MAP3K110.44272926
97PRKCQ0.44262138
98RPS6KA60.43520083
99MAPKAPK20.43471130
100CDK60.42059123
101MAP3K100.40953351
102SIK20.40880402
103IGF1R0.39679076
104PTK60.36594247
105RAF10.35326102
106RPS6KL10.35255003
107RPS6KC10.35255003
108MAP2K40.34379536
109CAMKK10.34225960
110PKN20.33978833
111STK240.32971196
112PDPK10.32043123
113PDK10.31828653
114RPS6KA20.31664682
115MAP3K10.29985044
116IRAK10.28753005
117PRKCH0.28409187
118MAP3K50.27603312
119PRKG20.27017621
120CAMK1D0.26526402
121TAOK20.26379335
122ALK0.25746624
123TNK20.25289408
124SCYL20.24969164
125FGFR40.23295969
126MAPK40.22320736

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.04629872
2Leishmaniasis_Homo sapiens_hsa051403.59077023
3Graft-versus-host disease_Homo sapiens_hsa053322.88658964
4Legionellosis_Homo sapiens_hsa051342.71094889
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.67249315
6Rheumatoid arthritis_Homo sapiens_hsa053232.67131544
7Tuberculosis_Homo sapiens_hsa051522.61804048
8Osteoclast differentiation_Homo sapiens_hsa043802.58769898
9Pertussis_Homo sapiens_hsa051332.51359037
10Lysosome_Homo sapiens_hsa041422.39255530
11Phagosome_Homo sapiens_hsa041452.38847113
12Malaria_Homo sapiens_hsa051442.33442911
13Asthma_Homo sapiens_hsa053102.28849922
14NF-kappa B signaling pathway_Homo sapiens_hsa040642.23038842
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.22623888
16NOD-like receptor signaling pathway_Homo sapiens_hsa046212.16908522
17Salmonella infection_Homo sapiens_hsa051322.07464782
18Allograft rejection_Homo sapiens_hsa053302.00874430
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.88599249
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.82923083
21Other glycan degradation_Homo sapiens_hsa005111.82471702
22Hematopoietic cell lineage_Homo sapiens_hsa046401.73294741
23RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.63487036
24Measles_Homo sapiens_hsa051621.62882947
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.55762564
26Complement and coagulation cascades_Homo sapiens_hsa046101.53077484
27TNF signaling pathway_Homo sapiens_hsa046681.52467962
28* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.51440825
29Type I diabetes mellitus_Homo sapiens_hsa049401.50344324
30Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.49654590
31* Chemokine signaling pathway_Homo sapiens_hsa040621.47341501
32B cell receptor signaling pathway_Homo sapiens_hsa046621.46065157
33Toxoplasmosis_Homo sapiens_hsa051451.43083268
34Influenza A_Homo sapiens_hsa051641.39347226
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.31668864
36Shigellosis_Homo sapiens_hsa051311.31033788
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25540196
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.20518697
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.17659935
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17377047
41Collecting duct acid secretion_Homo sapiens_hsa049661.15489954
42Jak-STAT signaling pathway_Homo sapiens_hsa046301.14455566
43Antigen processing and presentation_Homo sapiens_hsa046121.13682001
44Amoebiasis_Homo sapiens_hsa051461.13501113
45Viral myocarditis_Homo sapiens_hsa054161.10470443
46Apoptosis_Homo sapiens_hsa042101.10376255
47African trypanosomiasis_Homo sapiens_hsa051431.08145842
48Herpes simplex infection_Homo sapiens_hsa051681.07215308
49Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.06626964
50Autoimmune thyroid disease_Homo sapiens_hsa053201.03446598
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97067985
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.96245081
53Hepatitis B_Homo sapiens_hsa051610.90578614
54Prion diseases_Homo sapiens_hsa050200.84862266
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79872355
56Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74637848
57Platelet activation_Homo sapiens_hsa046110.73900763
58Primary immunodeficiency_Homo sapiens_hsa053400.71030239
59Hepatitis C_Homo sapiens_hsa051600.70721918
60T cell receptor signaling pathway_Homo sapiens_hsa046600.69564093
61Non-small cell lung cancer_Homo sapiens_hsa052230.69342726
62Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56518193
63SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52860247
64Acute myeloid leukemia_Homo sapiens_hsa052210.52698187
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.51366843
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51111769
67Notch signaling pathway_Homo sapiens_hsa043300.50346315
68Bladder cancer_Homo sapiens_hsa052190.49992216
69Pancreatic cancer_Homo sapiens_hsa052120.49443548
70Vibrio cholerae infection_Homo sapiens_hsa051100.49089201
71Mineral absorption_Homo sapiens_hsa049780.47788624
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.47557020
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46679116
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.46111712
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45189818
76GnRH signaling pathway_Homo sapiens_hsa049120.44938946
77Chronic myeloid leukemia_Homo sapiens_hsa052200.42584023
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42482746
79Endocytosis_Homo sapiens_hsa041440.41406873
80Caffeine metabolism_Homo sapiens_hsa002320.41102536
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40575290
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39940358
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39643073
84Sphingolipid metabolism_Homo sapiens_hsa006000.37142156
85HTLV-I infection_Homo sapiens_hsa051660.36940224
86Proteoglycans in cancer_Homo sapiens_hsa052050.36863586
87HIF-1 signaling pathway_Homo sapiens_hsa040660.35949446
88Renin-angiotensin system_Homo sapiens_hsa046140.35521555
89VEGF signaling pathway_Homo sapiens_hsa043700.34821149
90Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.33209100
91Galactose metabolism_Homo sapiens_hsa000520.31913776
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31361467
93Epstein-Barr virus infection_Homo sapiens_hsa051690.31076741
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.31009135
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30152207
96mTOR signaling pathway_Homo sapiens_hsa041500.28540507
97Arachidonic acid metabolism_Homo sapiens_hsa005900.28201528
98Endometrial cancer_Homo sapiens_hsa052130.24761099
99MAPK signaling pathway_Homo sapiens_hsa040100.24491638
100Histidine metabolism_Homo sapiens_hsa003400.24078687
101Prolactin signaling pathway_Homo sapiens_hsa049170.22026450
102Viral carcinogenesis_Homo sapiens_hsa052030.21946053
103Dorso-ventral axis formation_Homo sapiens_hsa043200.18847133
104Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18442746
105Steroid biosynthesis_Homo sapiens_hsa001000.15896330
106Insulin resistance_Homo sapiens_hsa049310.15580094
107Type II diabetes mellitus_Homo sapiens_hsa049300.13613440
108Renal cell carcinoma_Homo sapiens_hsa052110.13145136
109Ether lipid metabolism_Homo sapiens_hsa005650.12185971
110Adherens junction_Homo sapiens_hsa045200.11893564
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.10547735
112Starch and sucrose metabolism_Homo sapiens_hsa005000.10486869
113FoxO signaling pathway_Homo sapiens_hsa040680.09006905

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