CCNI2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.91174316
2gamma-aminobutyric acid transport (GO:0015812)4.67994310
3water-soluble vitamin biosynthetic process (GO:0042364)4.56027474
4behavioral response to nicotine (GO:0035095)4.26859128
5DNA deamination (GO:0045006)4.11150050
6regulation of female receptivity (GO:0045924)4.10581209
7protein polyglutamylation (GO:0018095)3.91543162
8detection of light stimulus involved in sensory perception (GO:0050962)3.73435466
9detection of light stimulus involved in visual perception (GO:0050908)3.73435466
10somite development (GO:0061053)3.62052195
11negative regulation of synaptic transmission, GABAergic (GO:0032229)3.54975515
12piRNA metabolic process (GO:0034587)3.49343558
13rRNA catabolic process (GO:0016075)3.37202500
14female mating behavior (GO:0060180)3.36879001
15transmission of nerve impulse (GO:0019226)3.34760937
16regulation of cilium movement (GO:0003352)3.32292401
17positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.26047881
18positive regulation of synapse maturation (GO:0090129)3.22814680
19DNA methylation involved in gamete generation (GO:0043046)3.19592545
20gamma-aminobutyric acid signaling pathway (GO:0007214)3.18704713
21glycine transport (GO:0015816)3.16858104
22regulation of action potential (GO:0098900)3.09742526
23cell proliferation in forebrain (GO:0021846)3.07783267
24positive regulation of triglyceride biosynthetic process (GO:0010867)3.06528404
25neuronal action potential propagation (GO:0019227)3.05011950
26negative regulation of response to food (GO:0032096)2.98646119
27negative regulation of appetite (GO:0032099)2.98646119
28membrane depolarization during action potential (GO:0086010)2.97013522
29cAMP catabolic process (GO:0006198)2.91445078
30regulation of acrosome reaction (GO:0060046)2.90131962
31cellular response to ATP (GO:0071318)2.89714260
32positive regulation of potassium ion transmembrane transport (GO:1901381)2.89175060
33sulfation (GO:0051923)2.88749553
34regulation of mesoderm development (GO:2000380)2.88184226
35regulation of glomerulus development (GO:0090192)2.87465321
36negative regulation of astrocyte differentiation (GO:0048712)2.84230840
37regulation of calcium ion-dependent exocytosis (GO:0017158)2.81515090
38regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.80736911
39regulation of rhodopsin mediated signaling pathway (GO:0022400)2.80175141
40DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.78878161
41endoderm formation (GO:0001706)2.77903638
42G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.76480841
43synaptic transmission, glutamatergic (GO:0035249)2.74130489
44serotonin metabolic process (GO:0042428)2.72082688
45negative regulation of mast cell activation (GO:0033004)2.71453790
46regulation of microtubule-based movement (GO:0060632)2.71173110
47parturition (GO:0007567)2.69274004
48regulation of synapse maturation (GO:0090128)2.69202385
49phosphorelay signal transduction system (GO:0000160)2.68697573
50cyclic nucleotide catabolic process (GO:0009214)2.68605988
51multicellular organism reproduction (GO:0032504)2.68447173
52rhodopsin mediated signaling pathway (GO:0016056)2.68329722
53axoneme assembly (GO:0035082)2.68094618
54ovulation cycle (GO:0042698)2.67104266
55calcium ion-dependent exocytosis (GO:0017156)2.64962330
56positive regulation of glomerulus development (GO:0090193)2.64294672
57neuron-neuron synaptic transmission (GO:0007270)2.63735765
58dentate gyrus development (GO:0021542)2.63640494
59cellular ketone body metabolic process (GO:0046950)2.63019659
60tachykinin receptor signaling pathway (GO:0007217)2.61625934
61primary amino compound metabolic process (GO:1901160)2.61327558
62protein K11-linked deubiquitination (GO:0035871)2.60647233
63cellular potassium ion homeostasis (GO:0030007)2.60457880
64magnesium ion transport (GO:0015693)2.59775118
65regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.56058040
66membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.55882943
67adaptation of signaling pathway (GO:0023058)2.54340018
68aggressive behavior (GO:0002118)2.53544860
69tryptophan catabolic process (GO:0006569)2.53275640
70indole-containing compound catabolic process (GO:0042436)2.53275640
71indolalkylamine catabolic process (GO:0046218)2.53275640
72epithelial cilium movement (GO:0003351)2.53164169
73cellular response to exogenous dsRNA (GO:0071360)2.52602160
74positive regulation of defense response to virus by host (GO:0002230)2.52309768
75kynurenine metabolic process (GO:0070189)2.51272548
76cerebellar Purkinje cell differentiation (GO:0021702)2.50799833
77glutamate receptor signaling pathway (GO:0007215)2.50703317
78regulation of synapse structural plasticity (GO:0051823)2.50271980
79interkinetic nuclear migration (GO:0022027)2.50000658
80synaptic vesicle maturation (GO:0016188)2.49548450
81positive regulation of mitochondrial fission (GO:0090141)2.46384777
82potassium ion import (GO:0010107)2.44368452
83membrane repolarization during action potential (GO:0086011)2.42933765
84central nervous system myelination (GO:0022010)2.42424281
85axon ensheathment in central nervous system (GO:0032291)2.42424281
86cytidine deamination (GO:0009972)2.41608019
87cytidine metabolic process (GO:0046087)2.41608019
88cytidine catabolic process (GO:0006216)2.41608019
89synaptic transmission, cholinergic (GO:0007271)2.41284569
90indolalkylamine metabolic process (GO:0006586)2.40490241
91multicellular organismal signaling (GO:0035637)2.40221973
92startle response (GO:0001964)2.39550561
93positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.39442373
94indole-containing compound metabolic process (GO:0042430)2.38980245
95RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.38656168
96positive regulation of histone H3-K4 methylation (GO:0051571)2.37152927
97action potential (GO:0001508)2.36880763
98positive regulation of action potential (GO:0045760)2.36455032
99regulation of germinal center formation (GO:0002634)2.36413079
100epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.36134841

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.35018381
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.60029449
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.96307254
4GBX2_23144817_ChIP-Seq_PC3_Human2.88483184
5REST_21632747_ChIP-Seq_MESCs_Mouse2.35232749
6NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.34608615
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.20070241
8BMI1_23680149_ChIP-Seq_NPCS_Mouse2.14134694
9VDR_22108803_ChIP-Seq_LS180_Human2.06106258
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04529238
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.98946184
12ZFP57_27257070_Chip-Seq_ESCs_Mouse1.95105961
13EZH2_27304074_Chip-Seq_ESCs_Mouse1.90710152
14JARID2_20075857_ChIP-Seq_MESCs_Mouse1.88338133
15ZNF274_21170338_ChIP-Seq_K562_Hela1.85573309
16REST_18959480_ChIP-ChIP_MESCs_Mouse1.82723911
17EZH2_27294783_Chip-Seq_ESCs_Mouse1.76013553
18NOTCH1_21737748_ChIP-Seq_TLL_Human1.72321648
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.71703647
20IRF1_19129219_ChIP-ChIP_H3396_Human1.71157894
21IGF1R_20145208_ChIP-Seq_DFB_Human1.70476542
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69821227
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.69405258
24CTBP1_25329375_ChIP-Seq_LNCAP_Human1.67393739
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.61693399
26RNF2_27304074_Chip-Seq_NSC_Mouse1.61174011
27SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60096606
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.59333579
29DROSHA_22980978_ChIP-Seq_HELA_Human1.56915997
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41525376
31FUS_26573619_Chip-Seq_HEK293_Human1.39917629
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38351250
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38351250
34CBX2_27304074_Chip-Seq_ESCs_Mouse1.37481967
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.36788647
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36229860
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36020650
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.33825648
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33644774
40TCF4_23295773_ChIP-Seq_U87_Human1.32951107
41EWS_26573619_Chip-Seq_HEK293_Human1.31659956
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.31388443
43RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30722059
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.30091062
45RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29851997
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.29702897
47PRDM14_20953172_ChIP-Seq_ESCs_Human1.28969659
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.28907013
49MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23742285
50ER_23166858_ChIP-Seq_MCF-7_Human1.23310756
51STAT3_23295773_ChIP-Seq_U87_Human1.21281227
52P300_19829295_ChIP-Seq_ESCs_Human1.20951545
53SMAD4_21799915_ChIP-Seq_A2780_Human1.19554086
54TP53_22573176_ChIP-Seq_HFKS_Human1.18943754
55GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17306922
56RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.15877754
57PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15802215
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15307591
59CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.15238839
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15086961
61MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12901786
62AR_25329375_ChIP-Seq_VCAP_Human1.11735305
63AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08669129
64STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.08445005
65CBP_20019798_ChIP-Seq_JUKART_Human1.07521798
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07521798
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06822493
68NCOR_22424771_ChIP-Seq_293T_Human1.06624545
69TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.06207390
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05893792
71NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04885930
72BCAT_22108803_ChIP-Seq_LS180_Human1.03866168
73TAF2_19829295_ChIP-Seq_ESCs_Human1.03139304
74RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03001544
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02889775
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02889775
77FOXA1_25329375_ChIP-Seq_VCAP_Human1.01525582
78FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01525582
79NANOG_18555785_Chip-Seq_ESCs_Mouse1.01485873
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01329472
81AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01276194
82TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99547990
83SMRT_27268052_Chip-Seq_Bcells_Human0.99520262
84IRF8_22096565_ChIP-ChIP_GC-B_Human0.98967376
85MYC_18940864_ChIP-ChIP_HL60_Human0.98184595
86ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97539065
87TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97417287
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95975015
89TAL1_26923725_Chip-Seq_HPCs_Mouse0.94256190
90P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93866021
91LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93608347
92SOX2_19829295_ChIP-Seq_ESCs_Human0.93134118
93NANOG_19829295_ChIP-Seq_ESCs_Human0.93134118
94TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.92288028
95GATA3_21878914_ChIP-Seq_MCF-7_Human0.91653965
96P53_22387025_ChIP-Seq_ESCs_Mouse0.91273718
97TAF15_26573619_Chip-Seq_HEK293_Human0.90967492
98ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90553522
99PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.89938184
100PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89763202

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005646_abnormal_pituitary_gland3.69111957
2MP0002138_abnormal_hepatobiliary_system3.11246836
3MP0008877_abnormal_DNA_methylation2.73085951
4MP0004859_abnormal_synaptic_plasticity2.71636960
5MP0004885_abnormal_endolymph2.58347595
6MP0003880_abnormal_central_pattern2.57521368
7MP0002876_abnormal_thyroid_physiology2.53252008
8MP0002272_abnormal_nervous_system2.45924676
9MP0009745_abnormal_behavioral_response2.41365828
10MP0002837_dystrophic_cardiac_calcinosis2.29091503
11MP0006292_abnormal_olfactory_placode2.21318466
12MP0003635_abnormal_synaptic_transmissio2.20062887
13MP0003879_abnormal_hair_cell2.16798394
14MP0009046_muscle_twitch2.13835760
15MP0003787_abnormal_imprinting2.12785830
16MP0005551_abnormal_eye_electrophysiolog2.05803106
17MP0005645_abnormal_hypothalamus_physiol2.01657717
18MP0002064_seizures2.00357334
19MP0004142_abnormal_muscle_tone1.93292873
20MP0003646_muscle_fatigue1.90409250
21MP0001968_abnormal_touch/_nociception1.86253207
22MP0002063_abnormal_learning/memory/cond1.84624642
23MP0000631_abnormal_neuroendocrine_gland1.79931046
24MP0003283_abnormal_digestive_organ1.79379378
25MP0005423_abnormal_somatic_nervous1.72404216
26MP0002163_abnormal_gland_morphology1.62280957
27MP0005671_abnormal_response_to1.61740082
28MP0002735_abnormal_chemical_nociception1.60282380
29MP0002572_abnormal_emotion/affect_behav1.57949038
30MP0008872_abnormal_physiological_respon1.54903735
31MP0002160_abnormal_reproductive_system1.54034948
32MP0001486_abnormal_startle_reflex1.51760156
33MP0002733_abnormal_thermal_nociception1.50820666
34MP0002734_abnormal_mechanical_nocicepti1.45172802
35MP0001970_abnormal_pain_threshold1.44816391
36MP0005310_abnormal_salivary_gland1.44069099
37MP0004145_abnormal_muscle_electrophysio1.43465523
38MP0001440_abnormal_grooming_behavior1.42522894
39MP0002822_catalepsy1.40461883
40MP0006072_abnormal_retinal_apoptosis1.39765616
41MP0004270_analgesia1.37019286
42MP0004130_abnormal_muscle_cell1.34283963
43MP0006276_abnormal_autonomic_nervous1.32928233
44MP0001986_abnormal_taste_sensitivity1.32163688
45MP0003195_calcinosis1.31828116
46MP0005389_reproductive_system_phenotype1.31488196
47MP0002557_abnormal_social/conspecific_i1.29910122
48MP0001905_abnormal_dopamine_level1.27927169
49MP0009780_abnormal_chondrocyte_physiolo1.27777179
50MP0001485_abnormal_pinna_reflex1.25620618
51MP0002736_abnormal_nociception_after1.24178431
52MP0002102_abnormal_ear_morphology1.20587326
53MP0005379_endocrine/exocrine_gland_phen1.18083703
54MP0001984_abnormal_olfaction1.17880826
55MP0003938_abnormal_ear_development1.17557526
56MP0010386_abnormal_urinary_bladder1.14775782
57MP0001963_abnormal_hearing_physiology1.14259248
58MP0003011_delayed_dark_adaptation1.13498349
59MP0004742_abnormal_vestibular_system1.05566714
60MP0000685_abnormal_immune_system1.05307562
61MP0005410_abnormal_fertilization1.04113913
62MP0001501_abnormal_sleep_pattern1.03441795
63MP0002184_abnormal_innervation1.03345449
64MP0002928_abnormal_bile_duct1.01557129
65MP0000026_abnormal_inner_ear1.00885787
66MP0002067_abnormal_sensory_capabilities0.98319711
67MP0008569_lethality_at_weaning0.96292462
68MP0003119_abnormal_digestive_system0.95988625
69MP0002229_neurodegeneration0.95366411
70MP0002693_abnormal_pancreas_physiology0.95114494
71MP0001919_abnormal_reproductive_system0.94750356
72MP0005253_abnormal_eye_physiology0.92711999
73MP0008789_abnormal_olfactory_epithelium0.92045783
74MP0002139_abnormal_hepatobiliary_system0.91674925
75MP0002882_abnormal_neuron_morphology0.90229415
76MP0002638_abnormal_pupillary_reflex0.89687951
77MP0002752_abnormal_somatic_nervous0.89058856
78MP0003633_abnormal_nervous_system0.84794799
79MP0005499_abnormal_olfactory_system0.84551809
80MP0005394_taste/olfaction_phenotype0.84551809
81MP0001800_abnormal_humoral_immune0.84375223
82MP0000049_abnormal_middle_ear0.84163551
83MP0001348_abnormal_lacrimal_gland0.83385299
84MP0002234_abnormal_pharynx_morphology0.82532593
85MP0004924_abnormal_behavior0.81720195
86MP0005386_behavior/neurological_phenoty0.81720195
87MP0000955_abnormal_spinal_cord0.79624537
88MP0004134_abnormal_chest_morphology0.79245842
89MP0005195_abnormal_posterior_eye0.77833323
90MP0002066_abnormal_motor_capabilities/c0.77073021
91MP0003718_maternal_effect0.77015597
92MP0002277_abnormal_respiratory_mucosa0.75613691
93MP0001188_hyperpigmentation0.75509665
94MP0000613_abnormal_salivary_gland0.74271492
95MP0001944_abnormal_pancreas_morphology0.73983153
96MP0003121_genomic_imprinting0.71020845
97MP0001790_abnormal_immune_system0.69414223
98MP0005387_immune_system_phenotype0.69414223
99MP0005075_abnormal_melanosome_morpholog0.69239648
100MP0001764_abnormal_homeostasis0.68713752

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.06459922
2Abnormal rod and cone electroretinograms (HP:0008323)3.70434175
3Absent rod-and cone-mediated responses on ERG (HP:0007688)3.59840614
4Pendular nystagmus (HP:0012043)3.54104039
5Pancreatic cysts (HP:0001737)3.39217423
6Pancreatic fibrosis (HP:0100732)3.21406147
7Nephronophthisis (HP:0000090)3.17582263
8Progressive cerebellar ataxia (HP:0002073)3.15344162
9Molar tooth sign on MRI (HP:0002419)3.08044412
10Abnormality of midbrain morphology (HP:0002418)3.08044412
11True hermaphroditism (HP:0010459)3.02640653
12Myokymia (HP:0002411)2.91675435
13Short 1st metacarpal (HP:0010034)2.87299205
14Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.87299205
15Severe visual impairment (HP:0001141)2.86793246
16Asplenia (HP:0001746)2.75390129
17IgG deficiency (HP:0004315)2.72208030
18Decreased central vision (HP:0007663)2.71316444
19Aplasia/Hypoplasia of the spleen (HP:0010451)2.71023627
20Methylmalonic acidemia (HP:0002912)2.70556792
21Medial flaring of the eyebrow (HP:0010747)2.68194035
22Attenuation of retinal blood vessels (HP:0007843)2.59210029
23Abnormality of the renal cortex (HP:0011035)2.55504556
24Abnormality of the 1st metacarpal (HP:0010009)2.54711675
25Agitation (HP:0000713)2.51597059
26Febrile seizures (HP:0002373)2.49049116
27Abnormality of the renal medulla (HP:0100957)2.48126952
28Abnormality of the proximal phalanges of the hand (HP:0009834)2.45384077
29Morphological abnormality of the middle ear (HP:0008609)2.44939936
30Hypoplasia of the uterus (HP:0000013)2.43665472
31Genetic anticipation (HP:0003743)2.40684234
32B lymphocytopenia (HP:0010976)2.39130882
33Focal seizures (HP:0007359)2.39109601
34Gaze-evoked nystagmus (HP:0000640)2.38279948
35Gait imbalance (HP:0002141)2.36824688
36Abnormality of B cell number (HP:0010975)2.36420374
37Abnormality of the nasal septum (HP:0000419)2.36114572
38Focal motor seizures (HP:0011153)2.34182460
39Bony spicule pigmentary retinopathy (HP:0007737)2.28683494
40Renal cortical cysts (HP:0000803)2.28654191
41Abolished electroretinogram (ERG) (HP:0000550)2.26063384
42Short hallux (HP:0010109)2.20158432
43Methylmalonic aciduria (HP:0012120)2.18679478
44Epileptic encephalopathy (HP:0200134)2.18360912
45Hyperthyroidism (HP:0000836)2.16558790
46Ketosis (HP:0001946)2.15249849
47Decreased circulating renin level (HP:0003351)2.13838781
48Symphalangism affecting the phalanges of the hand (HP:0009773)2.13579128
49Aplasia/Hypoplasia of the hallux (HP:0008362)2.13046481
50Nephrogenic diabetes insipidus (HP:0009806)2.12323670
51Thyroid-stimulating hormone excess (HP:0002925)2.12071583
52Abnormality of the middle phalanges of the toes (HP:0010183)2.11352817
53Congenital primary aphakia (HP:0007707)2.10145832
54Aplasia/hypoplasia of the uterus (HP:0008684)2.09427511
55Stenosis of the external auditory canal (HP:0000402)2.07804643
56Recurrent sinusitis (HP:0011108)2.07131926
57Aplasia/Hypoplasia of the fovea (HP:0008060)2.06104492
58Hypoplasia of the fovea (HP:0007750)2.06104492
59Hyperglycinemia (HP:0002154)2.06013240
60Furrowed tongue (HP:0000221)2.05570909
61Increased corneal curvature (HP:0100692)2.04161199
62Keratoconus (HP:0000563)2.04161199
63Cystic liver disease (HP:0006706)2.03685718
64Acute necrotizing encephalopathy (HP:0006965)2.02539240
65Abnormal drinking behavior (HP:0030082)1.98026339
66Polydipsia (HP:0001959)1.98026339
67Diplopia (HP:0000651)1.97169743
68Abnormality of binocular vision (HP:0011514)1.97169743
69Limb dystonia (HP:0002451)1.96811687
70Pigmentary retinal degeneration (HP:0001146)1.95138391
71Chorioretinal atrophy (HP:0000533)1.94266113
72Hemiparesis (HP:0001269)1.91832836
73Broad-based gait (HP:0002136)1.91409296
74Sclerocornea (HP:0000647)1.90974203
75Progressive macrocephaly (HP:0004481)1.90715988
76Short phalanx of the thumb (HP:0009660)1.88918273
77Goiter (HP:0000853)1.86659883
78Tubular atrophy (HP:0000092)1.86365267
79Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.85219495
80Mitochondrial inheritance (HP:0001427)1.84336148
81Synostosis involving the elbow (HP:0003938)1.83275690
82Humeroradial synostosis (HP:0003041)1.83275690
83Chronic hepatic failure (HP:0100626)1.83033005
84Abnormality of DNA repair (HP:0003254)1.82984546
85Dialeptic seizures (HP:0011146)1.80670932
86Vaginal atresia (HP:0000148)1.79650613
87Genital tract atresia (HP:0001827)1.79342338
88Visual hallucinations (HP:0002367)1.78786787
89Dynein arm defect of respiratory motile cilia (HP:0012255)1.77358399
90Absent/shortened dynein arms (HP:0200106)1.77358399
91Type II lissencephaly (HP:0007260)1.77253297
92Congenital hepatic fibrosis (HP:0002612)1.75406094
93Status epilepticus (HP:0002133)1.74511940
94Tachypnea (HP:0002789)1.74154637
95Optic disc pallor (HP:0000543)1.74145330
96Male pseudohermaphroditism (HP:0000037)1.72471236
97Abnormal mitochondria in muscle tissue (HP:0008316)1.71110828
98Lipid accumulation in hepatocytes (HP:0006561)1.70338767
993-Methylglutaconic aciduria (HP:0003535)1.69392244
100Thyroiditis (HP:0100646)1.68846584

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.25880282
2FRK4.23013672
3GRK12.86772631
4PINK12.74904676
5TAOK32.52467586
6MAP4K22.32534066
7BCKDK2.32223146
8MAPK132.26434684
9TLK12.02057454
10ADRBK21.81113416
11CASK1.76045054
12BMPR1B1.74392682
13NTRK31.72737631
14CAMKK11.71872758
15SIK21.69781295
16DAPK21.61367339
17BLK1.60703130
18CAMKK21.60330565
19MARK11.58018795
20ZAK1.54310597
21MAPKAPK51.53225478
22EPHA41.43928617
23PLK21.41079460
24NTRK21.36502027
25NEK11.35519962
26NUAK11.29523438
27PHKG21.25880470
28PHKG11.25880470
29STK161.25274169
30PRKCG1.21625875
31CDK191.18466834
32PASK1.18372330
33GRK51.17770210
34ARAF1.11520448
35TNK21.09116816
36PRKCQ1.08616052
37VRK11.07835553
38MAP4K11.03868483
39MAP3K41.00794417
40CSNK1G20.97970525
41WNK30.97025599
42TXK0.96176794
43WNK40.94515782
44RIPK40.92895295
45OXSR10.90403443
46SYK0.90122503
47DYRK20.90117736
48RPS6KA50.89098307
49TNIK0.87405953
50INSRR0.87213816
51MAPKAPK30.85782900
52PRKCH0.85441614
53TEC0.84519619
54ITK0.80329199
55PRKCI0.79804094
56PDK10.79426549
57MAP2K70.77494609
58PAK30.76944850
59CSNK1G30.74614262
60CAMK10.74075427
61DAPK10.72782931
62AURKA0.71858847
63CAMK2A0.71657040
64PRKCZ0.71549498
65IKBKB0.71110210
66STK110.69863801
67CSNK1A10.69170373
68CDK50.68495768
69STK390.67224866
70UHMK10.65250798
71PRKACA0.64622390
72PKN10.63953101
73KIT0.62772371
74SGK20.62425066
75NME10.60282439
76MINK10.58816069
77PRKCE0.58467348
78PRKD20.56449551
79CAMK2B0.54775164
80BRAF0.54364351
81CAMK40.53558402
82PAK60.52649657
83LYN0.51697780
84SGK10.51081822
85PLK40.50746911
86CSNK1G10.49694058
87CDK90.49075157
88RPS6KA20.49073998
89SGK2230.48492604
90SGK4940.48492604
91HIPK20.48138690
92RPS6KA60.47762665
93BTK0.46860067
94ACVR1B0.46557378
95CSNK1A1L0.45784160
96PRKCA0.44897408
97PRKD30.42377027
98RPS6KA30.40131021
99PIM10.39250161
100PRKAA10.38516402

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.59776351
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.67315373
3Phototransduction_Homo sapiens_hsa047442.61788385
4Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.56082801
5Primary immunodeficiency_Homo sapiens_hsa053402.55962042
6Morphine addiction_Homo sapiens_hsa050322.43043302
7Asthma_Homo sapiens_hsa053102.11370347
8Type I diabetes mellitus_Homo sapiens_hsa049402.04585580
9Insulin secretion_Homo sapiens_hsa049112.01130917
10Maturity onset diabetes of the young_Homo sapiens_hsa049501.98527028
11Allograft rejection_Homo sapiens_hsa053301.97067395
12GABAergic synapse_Homo sapiens_hsa047271.89758923
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.82640688
14Autoimmune thyroid disease_Homo sapiens_hsa053201.82559852
15Linoleic acid metabolism_Homo sapiens_hsa005911.74828202
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.72653343
17Circadian entrainment_Homo sapiens_hsa047131.67854141
18Glutamatergic synapse_Homo sapiens_hsa047241.62882881
19Oxidative phosphorylation_Homo sapiens_hsa001901.59898863
20Systemic lupus erythematosus_Homo sapiens_hsa053221.56841379
21Cardiac muscle contraction_Homo sapiens_hsa042601.52772269
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.52340852
23Caffeine metabolism_Homo sapiens_hsa002321.51278983
24Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.49407307
25Graft-versus-host disease_Homo sapiens_hsa053321.49034644
26Regulation of autophagy_Homo sapiens_hsa041401.48186126
27Taste transduction_Homo sapiens_hsa047421.44854282
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.44250159
29Synaptic vesicle cycle_Homo sapiens_hsa047211.40295176
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35213148
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.32528264
32Olfactory transduction_Homo sapiens_hsa047401.30598266
33Salivary secretion_Homo sapiens_hsa049701.27219055
34Serotonergic synapse_Homo sapiens_hsa047261.25196375
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.23095890
36Amphetamine addiction_Homo sapiens_hsa050311.22068990
37Cholinergic synapse_Homo sapiens_hsa047251.22002218
38Nitrogen metabolism_Homo sapiens_hsa009101.21686836
39Dorso-ventral axis formation_Homo sapiens_hsa043201.19336327
40Butanoate metabolism_Homo sapiens_hsa006501.18788511
41Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18280926
42RNA degradation_Homo sapiens_hsa030181.16085611
43Dopaminergic synapse_Homo sapiens_hsa047281.15011374
44Parkinsons disease_Homo sapiens_hsa050121.14176449
45Homologous recombination_Homo sapiens_hsa034401.14085209
46Sulfur relay system_Homo sapiens_hsa041221.08503477
47Alcoholism_Homo sapiens_hsa050341.06296406
48Sulfur metabolism_Homo sapiens_hsa009200.98327594
49Gastric acid secretion_Homo sapiens_hsa049710.98010178
50Cocaine addiction_Homo sapiens_hsa050300.96575162
51Long-term depression_Homo sapiens_hsa047300.95221575
52Glycerolipid metabolism_Homo sapiens_hsa005610.95059798
53Calcium signaling pathway_Homo sapiens_hsa040200.93728724
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93288442
55Alzheimers disease_Homo sapiens_hsa050100.91698488
56Ether lipid metabolism_Homo sapiens_hsa005650.88492432
57Steroid hormone biosynthesis_Homo sapiens_hsa001400.87221677
58Type II diabetes mellitus_Homo sapiens_hsa049300.86728928
59Oxytocin signaling pathway_Homo sapiens_hsa049210.86670741
60Long-term potentiation_Homo sapiens_hsa047200.84163232
61Renin secretion_Homo sapiens_hsa049240.83344567
62Retinol metabolism_Homo sapiens_hsa008300.82534300
63Basal transcription factors_Homo sapiens_hsa030220.81901590
64Ovarian steroidogenesis_Homo sapiens_hsa049130.75536374
65cAMP signaling pathway_Homo sapiens_hsa040240.72848127
66Tryptophan metabolism_Homo sapiens_hsa003800.72433026
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71489206
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70999523
69Chemical carcinogenesis_Homo sapiens_hsa052040.70802682
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.69294859
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63281990
72Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62286059
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.61857051
74Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.60272039
75Huntingtons disease_Homo sapiens_hsa050160.56940962
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56691879
77Propanoate metabolism_Homo sapiens_hsa006400.55372216
78Pancreatic secretion_Homo sapiens_hsa049720.53863144
79One carbon pool by folate_Homo sapiens_hsa006700.51230279
80MAPK signaling pathway_Homo sapiens_hsa040100.50793059
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.45092465
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.44768471
83Fanconi anemia pathway_Homo sapiens_hsa034600.44336760
84Fat digestion and absorption_Homo sapiens_hsa049750.44075610
85Ribosome_Homo sapiens_hsa030100.42896390
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42729620
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42403689
88Rheumatoid arthritis_Homo sapiens_hsa053230.41499564
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40866072
90Peroxisome_Homo sapiens_hsa041460.40770903
91Hematopoietic cell lineage_Homo sapiens_hsa046400.39795770
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.39321687
93Vascular smooth muscle contraction_Homo sapiens_hsa042700.37407944
94Collecting duct acid secretion_Homo sapiens_hsa049660.37173086
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36698457
96Fatty acid biosynthesis_Homo sapiens_hsa000610.35588860
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.35367147
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34889090
99B cell receptor signaling pathway_Homo sapiens_hsa046620.33404045
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32006413

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