CCNI

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin shows the highest similarity with cyclin G. The transcript of this gene was found to be expressed constantly during cell cycle progression. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.70920687
2neuron cell-cell adhesion (GO:0007158)4.67887428
3regulation of synaptic vesicle exocytosis (GO:2000300)4.58773484
4establishment of mitochondrion localization (GO:0051654)4.50777825
5axonal fasciculation (GO:0007413)4.46719813
6synaptic vesicle exocytosis (GO:0016079)4.45592225
7neuron recognition (GO:0008038)4.37687953
8vocalization behavior (GO:0071625)4.22488757
9cell migration in hindbrain (GO:0021535)4.20144742
10postsynaptic membrane organization (GO:0001941)4.19333614
11protein localization to synapse (GO:0035418)4.15799481
12presynaptic membrane organization (GO:0097090)4.11891007
13regulation of synaptic vesicle transport (GO:1902803)4.01020565
14ionotropic glutamate receptor signaling pathway (GO:0035235)3.97152955
15establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.91480694
16mitochondrion transport along microtubule (GO:0047497)3.91480694
17membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.87474718
18layer formation in cerebral cortex (GO:0021819)3.86102387
19presynaptic membrane assembly (GO:0097105)3.85396788
20cerebellar granule cell differentiation (GO:0021707)3.82344307
21neurotransmitter secretion (GO:0007269)3.82049092
22regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.76537198
23neuronal ion channel clustering (GO:0045161)3.72840375
24synaptic vesicle docking involved in exocytosis (GO:0016081)3.68824972
25regulation of synapse structural plasticity (GO:0051823)3.63922629
26regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.63027559
27cerebellar Purkinje cell differentiation (GO:0021702)3.62819824
28auditory behavior (GO:0031223)3.61908636
29adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.61122080
30exploration behavior (GO:0035640)3.55849740
31synapse assembly (GO:0007416)3.48510559
32positive regulation of dendritic spine morphogenesis (GO:0061003)3.43972277
33neurotransmitter-gated ion channel clustering (GO:0072578)3.37011583
34substrate-independent telencephalic tangential migration (GO:0021826)3.34659975
35substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.34659975
36glutamate receptor signaling pathway (GO:0007215)3.34344160
37neuron-neuron synaptic transmission (GO:0007270)3.27346112
38synaptic transmission, glutamatergic (GO:0035249)3.26693539
39mechanosensory behavior (GO:0007638)3.24838485
40central nervous system projection neuron axonogenesis (GO:0021952)3.23852482
41growth hormone receptor signaling pathway (GO:0060396)3.23598893
42cell differentiation in hindbrain (GO:0021533)3.22727411
43positive regulation of membrane potential (GO:0045838)3.20989446
44regulation of glutamate receptor signaling pathway (GO:1900449)3.20567917
45positive regulation of synapse assembly (GO:0051965)3.19817652
46transmission of nerve impulse (GO:0019226)3.19734059
47neurofilament cytoskeleton organization (GO:0060052)3.19238358
48cerebral cortex radially oriented cell migration (GO:0021799)3.18604996
49protein localization to endosome (GO:0036010)3.14613895
50positive regulation of synapse maturation (GO:0090129)3.13660445
51negative regulation of microtubule polymerization (GO:0031115)3.12394747
52regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.08825897
53gamma-aminobutyric acid transport (GO:0015812)3.07179657
54regulation of neuronal synaptic plasticity (GO:0048168)3.06060388
55regulation of excitatory postsynaptic membrane potential (GO:0060079)3.03623600
56regulation of postsynaptic membrane potential (GO:0060078)3.00754904
57synaptic vesicle maturation (GO:0016188)3.00618297
58positive regulation of fatty acid beta-oxidation (GO:0032000)3.00515217
59organelle transport along microtubule (GO:0072384)2.99826147
60regulation of vesicle fusion (GO:0031338)2.99708288
61sodium ion export (GO:0071436)2.99510229
62neurotransmitter transport (GO:0006836)2.98856820
63dendritic spine organization (GO:0097061)2.97425507
64regulation of fatty acid beta-oxidation (GO:0031998)2.96715836
65regulation of long-term neuronal synaptic plasticity (GO:0048169)2.93682158
66synaptic vesicle endocytosis (GO:0048488)2.92453661
67neuronal action potential propagation (GO:0019227)2.92321759
68dopamine receptor signaling pathway (GO:0007212)2.92044946
69adult walking behavior (GO:0007628)2.89182778
70alpha-linolenic acid metabolic process (GO:0036109)2.88579207
71regulation of synaptic transmission, glutamatergic (GO:0051966)2.88115427
72negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.86762470
73establishment of nucleus localization (GO:0040023)2.86617519
74response to auditory stimulus (GO:0010996)2.84384808
75positive regulation of histone deacetylation (GO:0031065)2.83686417
76regulation of neurotransmitter levels (GO:0001505)2.83574527
77cellular response to growth hormone stimulus (GO:0071378)2.82769208
78spinal cord association neuron differentiation (GO:0021527)2.78283260
79regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.77573595
80cytoskeletal anchoring at plasma membrane (GO:0007016)2.77546020
81insulin-like growth factor receptor signaling pathway (GO:0048009)2.77268219
82regulation of neurotransmitter secretion (GO:0046928)2.77153387
83neuromuscular synaptic transmission (GO:0007274)2.76876145
84regulation of dendritic spine morphogenesis (GO:0061001)2.76768597
85synapse organization (GO:0050808)2.75733992
86positive regulation of dendritic spine development (GO:0060999)2.75368386
87pyrimidine nucleobase catabolic process (GO:0006208)2.72998930
88behavioral defense response (GO:0002209)2.72879929
89behavioral fear response (GO:0001662)2.72879929
90dendrite development (GO:0016358)2.72343854
91cytoplasmic mRNA processing body assembly (GO:0033962)2.71423752
92behavioral response to cocaine (GO:0048148)2.70810663
93membrane depolarization during action potential (GO:0086010)2.70537473
94clathrin coat assembly (GO:0048268)2.69499129
95negative regulation of axonogenesis (GO:0050771)2.69327114
96regulation of voltage-gated calcium channel activity (GO:1901385)2.65600177
97membrane depolarization (GO:0051899)2.64863130
98response to histamine (GO:0034776)2.64622027
99positive regulation of fatty acid oxidation (GO:0046321)2.64186008
100regulation of synapse maturation (GO:0090128)2.63030410
101neuron projection extension (GO:1990138)2.63027245
102locomotory exploration behavior (GO:0035641)2.60639092
103negative regulation of synaptic transmission, GABAergic (GO:0032229)2.60401419
104activation of protein kinase A activity (GO:0034199)2.57129677
105nerve growth factor signaling pathway (GO:0038180)2.55467005
106positive regulation of glycogen biosynthetic process (GO:0045725)2.54334409
107nucleobase catabolic process (GO:0046113)2.53266394
108membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.52005068
109germ cell migration (GO:0008354)2.44699693
110glial cell proliferation (GO:0014009)2.40926977
111cellular potassium ion homeostasis (GO:0030007)2.40708256
112membrane repolarization during action potential (GO:0086011)2.38777453
113regulation of ARF protein signal transduction (GO:0032012)2.36726031
114negative regulation of fatty acid transport (GO:2000192)2.34960048
115dendrite morphogenesis (GO:0048813)2.34874856
116regulation of fatty acid oxidation (GO:0046320)2.33455725
117lysine catabolic process (GO:0006554)2.29114108
118lysine metabolic process (GO:0006553)2.29114108
119positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.29011059
120dendritic spine morphogenesis (GO:0060997)2.27001670
121regulation of ARF GTPase activity (GO:0032312)2.26116626
122peptidyl-lysine dimethylation (GO:0018027)2.26057039
123negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.24505891
124low-density lipoprotein particle clearance (GO:0034383)2.24473199
125positive regulation of lipid catabolic process (GO:0050996)2.23018171
126regulation of cholesterol homeostasis (GO:2000188)2.22800559
127regulation of polysaccharide biosynthetic process (GO:0032885)2.22239260
128regulation of cholesterol storage (GO:0010885)2.21723860
129acylglycerol catabolic process (GO:0046464)2.20432070
130neutral lipid catabolic process (GO:0046461)2.20432070
131proline transport (GO:0015824)2.19905061
132alanine transport (GO:0032328)2.19810618
133peptidyl-threonine modification (GO:0018210)2.17837787
134negative regulation of catenin import into nucleus (GO:0035414)2.16915093
135triglyceride catabolic process (GO:0019433)2.16063306
136mating behavior (GO:0007617)2.15190025
137potassium ion import (GO:0010107)2.14787721
138negative regulation of cell size (GO:0045792)2.12759782
139signal complex assembly (GO:0007172)2.12735343
140regulation of clathrin-mediated endocytosis (GO:2000369)2.12706941
141glucocorticoid receptor signaling pathway (GO:0042921)2.09519310
142response to nerve growth factor (GO:1990089)2.09226950
143cellular response to nerve growth factor stimulus (GO:1990090)2.09226950
144dicarboxylic acid biosynthetic process (GO:0043650)2.08933195
145cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.08848397
146positive regulation of glycogen metabolic process (GO:0070875)2.08759008
147negative regulation of heart growth (GO:0061117)2.05547061
148negative regulation of cardiac muscle tissue growth (GO:0055022)2.05547061
149membrane repolarization (GO:0086009)2.05118835
150regulation of glycogen (starch) synthase activity (GO:2000465)2.04554919
151regulation of sequestering of triglyceride (GO:0010889)2.04414041
152glutamate secretion (GO:0014047)2.04197897
153peptidyl-threonine phosphorylation (GO:0018107)2.03451066
154hypotonic response (GO:0006971)2.03123527
155regulation of NFAT protein import into nucleus (GO:0051532)2.02869172
156valine metabolic process (GO:0006573)2.02831428
157regulation of p38MAPK cascade (GO:1900744)2.02256328
158positive regulation of glucose import (GO:0046326)2.01904734
159fatty acid transmembrane transport (GO:1902001)2.00468748
160positive regulation of hormone biosynthetic process (GO:0046886)2.00449123
161protein targeting to Golgi (GO:0000042)2.00146332
162receptor catabolic process (GO:0032801)1.99440096
163positive regulation of nitric-oxide synthase activity (GO:0051000)1.99078597
164negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)1.98250558
165cell communication by electrical coupling (GO:0010644)1.97932196
166carnitine shuttle (GO:0006853)1.97575595
167tricarboxylic acid metabolic process (GO:0072350)1.95291446
168establishment of protein localization to Golgi (GO:0072600)1.94875019
169cellular response to lithium ion (GO:0071285)1.93870769
170positive regulation of synaptic transmission, dopaminergic (GO:0032226)1.93387706
171hippo signaling (GO:0035329)1.92669614
172macroautophagy (GO:0016236)1.91933038
173retrograde transport, vesicle recycling within Golgi (GO:0000301)1.91644117
174stress fiber assembly (GO:0043149)1.91243674
175regulation of short-term neuronal synaptic plasticity (GO:0048172)1.91203952
1764-hydroxyproline metabolic process (GO:0019471)1.90874238
177suckling behavior (GO:0001967)1.90622860
178lipid translocation (GO:0034204)1.90031783
179phospholipid translocation (GO:0045332)1.90031783
180amino-acid betaine transport (GO:0015838)1.89601827
181carnitine transport (GO:0015879)1.89601827
182axon extension (GO:0048675)1.89109128
183negative regulation of potassium ion transmembrane transporter activity (GO:1901017)1.88785176
184positive regulation of axon extension (GO:0045773)1.88059107
185cellular sodium ion homeostasis (GO:0006883)1.87997824

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.00326650
2REST_21632747_ChIP-Seq_MESCs_Mouse2.84836329
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.66185275
4GBX2_23144817_ChIP-Seq_PC3_Human2.53659353
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.45247306
6CBX2_27304074_Chip-Seq_ESCs_Mouse2.33453097
7PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.31945426
8REST_18959480_ChIP-ChIP_MESCs_Mouse2.26941575
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.12181139
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10943163
11CLOCK_20551151_ChIP-Seq_293T_Human2.05652039
12RNF2_27304074_Chip-Seq_NSC_Mouse2.03632562
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.01315745
14BMI1_23680149_ChIP-Seq_NPCS_Mouse1.92170540
15WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.88810375
16TAF15_26573619_Chip-Seq_HEK293_Human1.86189521
17TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.81133451
18RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.80648780
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.72479185
20KDM2B_26808549_Chip-Seq_K562_Human1.72305452
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71770021
22IGF1R_20145208_ChIP-Seq_DFB_Human1.71695313
23ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.70999109
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67588985
25TRIM28_21343339_ChIP-Seq_HEK293_Human1.65701987
26SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64949823
27LXR_22158963_ChIP-Seq_LIVER_Mouse1.62283507
28DROSHA_22980978_ChIP-Seq_HELA_Human1.61959790
29ZNF217_24962896_ChIP-Seq_MCF-7_Human1.61424039
30KDM2B_26808549_Chip-Seq_DND41_Human1.60299069
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.57860048
32ZNF263_19887448_ChIP-Seq_K562_Human1.57485109
33EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.54681457
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53744589
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.53101036
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.51508765
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.50785161
38* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.47321591
39EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45915537
40EZH2_18974828_ChIP-Seq_MESCs_Mouse1.45150580
41RNF2_18974828_ChIP-Seq_MESCs_Mouse1.45150580
42* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44437050
43NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.43976755
44DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.43841981
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43144589
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43144589
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.42502277
48RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.42335618
49TCF7_22412390_ChIP-Seq_EML_Mouse1.41810896
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.41231258
51KDM2B_26808549_Chip-Seq_JURKAT_Human1.39152519
52MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38796713
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.37841309
54CTBP1_25329375_ChIP-Seq_LNCAP_Human1.35371102
55KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.34808547
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34208210
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.33624927
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31312061
59SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.30736089
60PPARA_22158963_ChIP-Seq_LIVER_Mouse1.29952254
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.29785125
62* FOXO3_23340844_ChIP-Seq_DLD1_Human1.29015223
63SMAD4_21799915_ChIP-Seq_A2780_Human1.28218175
64WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28015025
65SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.26330238
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25974860
67RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25763061
68* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25126708
69RARB_27405468_Chip-Seq_BRAIN_Mouse1.25113377
70AHR_22903824_ChIP-Seq_MCF-7_Human1.24987426
71EZH2_22144423_ChIP-Seq_EOC_Human1.24941677
72SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24861880
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.24182472
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23989876
75* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.23350869
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.23115379
77OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22773006
78RNF2_27304074_Chip-Seq_ESCs_Mouse1.22410930
79EGR1_19374776_ChIP-ChIP_THP-1_Human1.21189140
80FOXA2_19822575_ChIP-Seq_HepG2_Human1.19608408
81SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.19013005
82KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.17157055
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16729027
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16450212
85JARID2_20064375_ChIP-Seq_MESCs_Mouse1.16351629
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15643113
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15219620
88GATA1_26923725_Chip-Seq_HPCs_Mouse1.14472507
89AR_21572438_ChIP-Seq_LNCaP_Human1.14276814
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14031616
91SUZ12_27294783_Chip-Seq_ESCs_Mouse1.13756036
92SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13208789
93CDX2_19796622_ChIP-Seq_MESCs_Mouse1.13199760
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13123168
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13011696
96SOX2_21211035_ChIP-Seq_LN229_Gbm1.12588300
97P300_19829295_ChIP-Seq_ESCs_Human1.12319761
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11384209
99EZH2_27294783_Chip-Seq_ESCs_Mouse1.10274806
100TBX20_22080862_ChIP-Seq_HEART_Mouse1.09262965
101TBX20_22328084_ChIP-Seq_HEART_Mouse1.09262965
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09146753
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08837833
104DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08705193
105* STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.08653063
106ERG_21242973_ChIP-ChIP_JURKAT_Human1.08177637
107SMAD3_21741376_ChIP-Seq_EPCs_Human1.07141873
108EP300_21415370_ChIP-Seq_HL-1_Mouse1.07122086
109BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.06872779
110JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06562680
111SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06159066
112FUS_26573619_Chip-Seq_HEK293_Human1.05915655
113* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05783810
114TP63_17297297_ChIP-ChIP_HaCaT_Human1.05490579
115LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05320716
116SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05120393
117PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04685107
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04434590
119SMAD_19615063_ChIP-ChIP_OVARY_Human1.03347747
120KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.02792438
121YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02598444
122* TP53_20018659_ChIP-ChIP_R1E_Mouse1.02394132
123STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02203351
124ISL1_27105846_Chip-Seq_CPCs_Mouse1.00953989
125AR_25329375_ChIP-Seq_VCAP_Human1.00861825
126LXR_22292898_ChIP-Seq_THP-1_Human1.00162505
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99323841
128SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98828630
129RING1B_27294783_Chip-Seq_NPCs_Mouse0.97406184
130GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97153504
131RUNX1_27514584_Chip-Seq_MCF-7_Human0.97134112
132THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97031021
133TCF4_23295773_ChIP-Seq_U87_Human0.96835401
134P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96651194
135SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96521136
136* RXR_22108803_ChIP-Seq_LS180_Human0.96186555
137STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96100820
138ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95721298
139RING1B_27294783_Chip-Seq_ESCs_Mouse0.95718357
140MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95506372
141VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95444749
142CREB1_26743006_Chip-Seq_LNCaP_Human0.95382181
143RUNX_20019798_ChIP-Seq_JUKART_Human0.94940422
144STAT3_23295773_ChIP-Seq_U87_Human0.94729575
145NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94393853
146MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93818336
147RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93689241
148KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.93678952
149FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93126311
150CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.91954133
151ESR1_21235772_ChIP-Seq_MCF-7_Human0.91856189
152ZNF274_21170338_ChIP-Seq_K562_Hela0.91601522
153SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.91331419
154FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.91132110
155STAT3_18555785_ChIP-Seq_MESCs_Mouse0.91000222
156* RUNX2_22187159_ChIP-Seq_PCA_Human0.90405936
157TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90199116
158FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.90123813
159TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89739630
160RACK7_27058665_Chip-Seq_MCF-7_Human0.89627648
161AR_19668381_ChIP-Seq_PC3_Human0.89558471
162CDX2_20551321_ChIP-Seq_CACO-2_Human0.89312532
163SALL1_21062744_ChIP-ChIP_HESCs_Human0.89253797
164EZH2_27304074_Chip-Seq_ESCs_Mouse0.88378261
165SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88222529
166FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87631803

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.06860039
2MP0003880_abnormal_central_pattern4.47645461
3MP0005423_abnormal_somatic_nervous3.53821594
4MP0003705_abnormal_hypodermis_morpholog3.46453832
5MP0003787_abnormal_imprinting3.44617259
6MP0002822_catalepsy3.21908298
7MP0003122_maternal_imprinting3.08454222
8MP0003300_gastrointestinal_ulcer3.06694433
9MP0008961_abnormal_basal_metabolism2.93381292
10MP0004185_abnormal_adipocyte_glucose2.72075145
11MP0004130_abnormal_muscle_cell2.60466346
12MP0002139_abnormal_hepatobiliary_system2.59063824
13MP0004859_abnormal_synaptic_plasticity2.49597532
14MP0002064_seizures2.39780262
15MP0003121_genomic_imprinting2.39710836
16MP0009780_abnormal_chondrocyte_physiolo2.39501434
17MP0009745_abnormal_behavioral_response2.38220536
18MP0000569_abnormal_digit_pigmentation2.29927129
19MP0002572_abnormal_emotion/affect_behav2.28245070
20MP0005360_urolithiasis2.24724599
21MP0002272_abnormal_nervous_system2.24512674
22MP0006276_abnormal_autonomic_nervous2.24055814
23MP0005666_abnormal_adipose_tissue2.20280293
24MP0001188_hyperpigmentation2.17686051
25MP0002909_abnormal_adrenal_gland2.16154191
26MP0002734_abnormal_mechanical_nocicepti2.14140517
27MP0001486_abnormal_startle_reflex2.10130828
28MP0002735_abnormal_chemical_nociception2.05863301
29MP0003303_peritoneal_inflammation1.99107334
30MP0009046_muscle_twitch1.95321330
31MP0005076_abnormal_cell_differentiation1.92290809
32MP0008877_abnormal_DNA_methylation1.90928473
33MP0003123_paternal_imprinting1.85516477
34MP0003252_abnormal_bile_duct1.84296339
35MP0003890_abnormal_embryonic-extraembry1.83877655
36MP0002557_abnormal_social/conspecific_i1.78712452
37MP0005375_adipose_tissue_phenotype1.74483157
38MP0001984_abnormal_olfaction1.74405912
39MP0000955_abnormal_spinal_cord1.74176158
40MP0005394_taste/olfaction_phenotype1.73816746
41MP0005499_abnormal_olfactory_system1.73816746
42MP0005623_abnormal_meninges_morphology1.73477351
43MP0002877_abnormal_melanocyte_morpholog1.72827383
44MP0000566_synostosis1.70245090
45MP0004858_abnormal_nervous_system1.67494058
46MP0001968_abnormal_touch/_nociception1.66752230
47MP0002067_abnormal_sensory_capabilities1.66384603
48MP0002184_abnormal_innervation1.65576811
49MP0000537_abnormal_urethra_morphology1.62562846
50MP0005167_abnormal_blood-brain_barrier1.60043809
51MP0009379_abnormal_foot_pigmentation1.59863323
52MP0001970_abnormal_pain_threshold1.59615026
53MP0004043_abnormal_pH_regulation1.57743887
54MP0001440_abnormal_grooming_behavior1.57612244
55MP0010329_abnormal_lipoprotein_level1.56712977
56MP0001529_abnormal_vocalization1.56673315
57MP0002882_abnormal_neuron_morphology1.56652122
58MP0004742_abnormal_vestibular_system1.55183042
59MP0002733_abnormal_thermal_nociception1.54711032
60MP0002138_abnormal_hepatobiliary_system1.54023710
61MP0004924_abnormal_behavior1.52574185
62MP0005386_behavior/neurological_phenoty1.52574185
63MP0004885_abnormal_endolymph1.49898585
64MP0005187_abnormal_penis_morphology1.49729269
65MP0001502_abnormal_circadian_rhythm1.49070141
66MP0004142_abnormal_muscle_tone1.48927771
67MP0003191_abnormal_cellular_cholesterol1.47963346
68MP0006292_abnormal_olfactory_placode1.43463389
69MP0001849_ear_inflammation1.39193642
70MP0000003_abnormal_adipose_tissue1.35861212
71MP0002152_abnormal_brain_morphology1.35174858
72MP0004270_analgesia1.31449411
73MP0002066_abnormal_motor_capabilities/c1.28236068
74MP0003938_abnormal_ear_development1.28084441
75MP0001501_abnormal_sleep_pattern1.26798125
76MP0002234_abnormal_pharynx_morphology1.25930848
77MP0005645_abnormal_hypothalamus_physiol1.25759534
78MP0010352_gastrointestinal_tract_polyps1.23046209
79MP0001905_abnormal_dopamine_level1.22481723
80MP0001879_abnormal_lymphatic_vessel1.21703641
81MP0002638_abnormal_pupillary_reflex1.19731127
82MP0002896_abnormal_bone_mineralization1.19068204
83MP0003635_abnormal_synaptic_transmissio1.18738993
84MP0000631_abnormal_neuroendocrine_gland1.17587088
85MP0005248_abnormal_Harderian_gland1.17023658
86MP0003045_fibrosis1.15354726
87MP0000013_abnormal_adipose_tissue1.14058628
88MP0005085_abnormal_gallbladder_physiolo1.12976402
89MP0002971_abnormal_brown_adipose1.12706608
90MP0008789_abnormal_olfactory_epithelium1.12700600
91MP0003861_abnormal_nervous_system1.12150515
92MP0003879_abnormal_hair_cell1.11927822
93MP0002752_abnormal_somatic_nervous1.10811083
94MP0009053_abnormal_anal_canal1.10442858
95MP0003329_amyloid_beta_deposits1.09423224
96MP0010678_abnormal_skin_adnexa1.09363093
97MP0010368_abnormal_lymphatic_system1.08248161
98MP0002736_abnormal_nociception_after1.07939536
99MP0005365_abnormal_bile_salt1.07283344
100MP0005275_abnormal_skin_tensile1.07083013
101MP0002254_reproductive_system_inflammat1.06885757
102MP0003091_abnormal_cell_migration1.03497556
103MP0003283_abnormal_digestive_organ1.02298759
104MP0002653_abnormal_ependyma_morphology1.02198839
105MP0001765_abnormal_ion_homeostasis1.01431021
106MP0001958_emphysema1.00455636
107MP0004133_heterotaxia1.00190305
108MP0002063_abnormal_learning/memory/cond0.99761889
109MP0000604_amyloidosis0.98926564
110MP0003566_abnormal_cell_adhesion0.96992693
111MP0002118_abnormal_lipid_homeostasis0.96514712
112MP0002009_preneoplasia0.96321211
113MP0003075_altered_response_to0.95339706
114MP0004272_abnormal_basement_membrane0.94165507
115MP0005535_abnormal_body_temperature0.93264326
116MP0000026_abnormal_inner_ear0.93118925
117MP0008995_early_reproductive_senescence0.93031930
118MP0008438_abnormal_cutaneous_collagen0.92965875
119MP0002069_abnormal_eating/drinking_beha0.92033867
120MP0003690_abnormal_glial_cell0.91993249
121MP0000733_abnormal_muscle_development0.91281437
122MP0003633_abnormal_nervous_system0.90590690
123MP0003631_nervous_system_phenotype0.89880352
124MP0005409_darkened_coat_color0.89876481
125MP0003195_calcinosis0.89337819
126MP0002837_dystrophic_cardiac_calcinosis0.88541939
127MP0009278_abnormal_bone_marrow0.87895254
128MP0000778_abnormal_nervous_system0.87613511
129MP0002166_altered_tumor_susceptibility0.85958024
130MP0006054_spinal_hemorrhage0.85927240
131MP0005670_abnormal_white_adipose0.85719322
132MP0000534_abnormal_ureter_morphology0.85715272
133MP0005646_abnormal_pituitary_gland0.85545284
134MP0005367_renal/urinary_system_phenotyp0.85515612
135MP0000516_abnormal_urinary_system0.85515612
136MP0001963_abnormal_hearing_physiology0.83666546
137MP0004811_abnormal_neuron_physiology0.82884960
138MP0002102_abnormal_ear_morphology0.82099695
139MP0004484_altered_response_of0.80866243
140MP0002229_neurodegeneration0.80407408
141MP0009384_cardiac_valve_regurgitation0.78698003
142MP0005551_abnormal_eye_electrophysiolog0.77538105
143MP0003567_abnormal_fetal_cardiomyocyte0.77534926
144MP0005334_abnormal_fat_pad0.76085135
145MP0001177_atelectasis0.75636717
146MP0001756_abnormal_urination0.74963736
147MP0001943_abnormal_respiration0.74156331
148MP0003115_abnormal_respiratory_system0.74073608
149MP0002928_abnormal_bile_duct0.73549202
150MP0004145_abnormal_muscle_electrophysio0.73201815
151MP0008569_lethality_at_weaning0.72809085
152MP0010630_abnormal_cardiac_muscle0.72794832
153MP0002078_abnormal_glucose_homeostasis0.72400211
154MP0001485_abnormal_pinna_reflex0.72259155
155MP0000609_abnormal_liver_physiology0.70708297
156MP0002751_abnormal_autonomic_nervous0.70089329
157MP0002081_perinatal_lethality0.69795254
158MP0000049_abnormal_middle_ear0.69567808
159MP0004510_myositis0.69264792
160MP0009115_abnormal_fat_cell0.67750959
161MP0002168_other_aberrant_phenotype0.66677509
162MP0002089_abnormal_postnatal_growth/wei0.65380071
163MP0006138_congestive_heart_failure0.65292027
164MP0004087_abnormal_muscle_fiber0.65167881
165* MP0009643_abnormal_urine_homeostasis0.64567780
166MP0005166_decreased_susceptibility_to0.64079587
167MP0004147_increased_porphyrin_level0.63877182
168MP0003119_abnormal_digestive_system0.63716363
169MP0003221_abnormal_cardiomyocyte_apopto0.63050996
170MP0003942_abnormal_urinary_system0.62985695
171MP0001986_abnormal_taste_sensitivity0.62642524
172MP0003453_abnormal_keratinocyte_physiol0.62533842
173MP0010770_preweaning_lethality0.62494860
174MP0002082_postnatal_lethality0.62494860
175MP0001270_distended_abdomen0.61594436
176MP0001299_abnormal_eye_distance/0.60129226
177MP0003172_abnormal_lysosome_physiology0.60128400
178MP0010769_abnormal_survival0.59744363
179MP0003632_abnormal_nervous_system0.59223289
180MP0010768_mortality/aging0.56940235

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.25916477
2Limb dystonia (HP:0002451)5.41361205
3Focal motor seizures (HP:0011153)4.29247308
4Focal seizures (HP:0007359)4.07154415
5Febrile seizures (HP:0002373)3.99882313
6Epileptic encephalopathy (HP:0200134)3.91762273
7Polyphagia (HP:0002591)3.84706797
8Abnormality of the corticospinal tract (HP:0002492)3.68731138
9Atonic seizures (HP:0010819)3.51021178
10Progressive cerebellar ataxia (HP:0002073)3.50350229
11Abnormal eating behavior (HP:0100738)3.43983423
12Drooling (HP:0002307)3.41183032
13Excessive salivation (HP:0003781)3.25269933
14Macroorchidism (HP:0000053)3.20471308
15Supranuclear gaze palsy (HP:0000605)3.15921052
16Sleep apnea (HP:0010535)3.10776115
17Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.09734320
18Degeneration of the lateral corticospinal tracts (HP:0002314)3.09734320
19Amyotrophic lateral sclerosis (HP:0007354)3.02655456
20Subacute progressive viral hepatitis (HP:0006572)2.93286923
21Spastic gait (HP:0002064)2.88040339
22Lymphangioma (HP:0100764)2.79001473
23Diplopia (HP:0000651)2.78171563
24Abnormality of binocular vision (HP:0011514)2.78171563
25Generalized tonic-clonic seizures (HP:0002069)2.77768296
26Impaired vibration sensation in the lower limbs (HP:0002166)2.77657936
27Broad-based gait (HP:0002136)2.77120561
28Epileptiform EEG discharges (HP:0011182)2.75934568
29Gait imbalance (HP:0002141)2.72675640
30Hyperventilation (HP:0002883)2.71315049
31Ankle clonus (HP:0011448)2.71243985
32Urinary bladder sphincter dysfunction (HP:0002839)2.66485312
33Hypsarrhythmia (HP:0002521)2.62658858
34EEG with generalized epileptiform discharges (HP:0011198)2.62372914
35Hematochezia (HP:0002573)2.61436724
36Papilledema (HP:0001085)2.59318486
37Dialeptic seizures (HP:0011146)2.51667513
38Morphological abnormality of the pyramidal tract (HP:0002062)2.50618232
39Absence seizures (HP:0002121)2.49498243
40Action tremor (HP:0002345)2.49360580
41Abnormal hair whorl (HP:0010721)2.45421786
42Enlarged penis (HP:0000040)2.45198128
43Absent speech (HP:0001344)2.39117097
44Neurofibrillary tangles (HP:0002185)2.35168114
45Status epilepticus (HP:0002133)2.34713994
46Specific learning disability (HP:0001328)2.32211303
47Buphthalmos (HP:0000557)2.30226876
48Failure to thrive in infancy (HP:0001531)2.28718563
49Torticollis (HP:0000473)2.25661456
50Visual hallucinations (HP:0002367)2.24521585
51Agitation (HP:0000713)2.23330115
52Insidious onset (HP:0003587)2.22995049
53Termporal pattern (HP:0011008)2.22995049
54Hamartoma of the eye (HP:0010568)2.22592537
55Lissencephaly (HP:0001339)2.20728276
56Mitral valve prolapse (HP:0001634)2.20589471
57Cerebral aneurysm (HP:0004944)2.20073153
58Abnormality of the labia minora (HP:0012880)2.18907283
59Visceral angiomatosis (HP:0100761)2.17460686
60Postural instability (HP:0002172)2.17300479
61Hypoplasia of the brainstem (HP:0002365)2.16909268
62Aplasia/Hypoplasia of the brainstem (HP:0007362)2.16909268
63Mutism (HP:0002300)2.16699110
64Abnormality of the lower motor neuron (HP:0002366)2.16652189
65Hyperacusis (HP:0010780)2.14832711
66Lower limb asymmetry (HP:0100559)2.14024579
67Dysmetric saccades (HP:0000641)2.13177538
68Hand muscle atrophy (HP:0009130)2.12066533
69Ketoacidosis (HP:0001993)2.11897599
70Spastic tetraplegia (HP:0002510)2.10495979
71Elfin facies (HP:0004428)2.09123051
72Shallow orbits (HP:0000586)2.07732176
73Rectal prolapse (HP:0002035)2.07287704
74Amblyopia (HP:0000646)2.07175941
75Peripheral hypomyelination (HP:0007182)2.05718904
76Hemangiomatosis (HP:0007461)2.05388010
77Ankyloglossia (HP:0010296)2.04769983
78Intention tremor (HP:0002080)2.04491405
79Aortic aneurysm (HP:0004942)2.04411830
80Pachygyria (HP:0001302)2.03924238
81Fetal akinesia sequence (HP:0001989)2.02945940
82Abnormality of chloride homeostasis (HP:0011422)1.99978713
83Deep venous thrombosis (HP:0002625)1.99891985
84Sporadic (HP:0003745)1.97433453
85Exostoses (HP:0100777)1.97023347
86Lower limb muscle weakness (HP:0007340)1.96837535
87Medial flaring of the eyebrow (HP:0010747)1.95993757
88Nephrogenic diabetes insipidus (HP:0009806)1.95235309
89Oligodactyly (hands) (HP:0001180)1.95177298
90Abnormality of salivation (HP:0100755)1.94301004
91Disinhibition (HP:0000734)1.93874427
92Hypokalemic alkalosis (HP:0001949)1.91991184
93Vascular tortuosity (HP:0004948)1.91572847
94Hypoplasia of the corpus callosum (HP:0002079)1.90370407
95Cerebral inclusion bodies (HP:0100314)1.90149697
96Long toe (HP:0010511)1.89791955
97Congenital primary aphakia (HP:0007707)1.89679572
98Shawl scrotum (HP:0000049)1.89671767
99Broad metatarsal (HP:0001783)1.89614520
100Hip dysplasia (HP:0001385)1.89108872
101Increased CSF protein (HP:0002922)1.88974138
102Retinal dysplasia (HP:0007973)1.88715549
103Complement deficiency (HP:0004431)1.88607291
104Thin bony cortex (HP:0002753)1.88481672
105Distal upper limb amyotrophy (HP:0007149)1.87395129
106Upper limb amyotrophy (HP:0009129)1.87395129
107Urinary urgency (HP:0000012)1.87381878
108Arterial tortuosity (HP:0005116)1.85344530
109Metabolic alkalosis (HP:0200114)1.82870056
110Aneurysm (HP:0002617)1.82579280
111Turricephaly (HP:0000262)1.82283740
112Back pain (HP:0003418)1.81683660
113Thyroid-stimulating hormone excess (HP:0002925)1.81561510
114Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.77719713
115Stereotypic behavior (HP:0000733)1.77690715
116Viral hepatitis (HP:0006562)1.76445134
117Exotropia (HP:0000577)1.76275582
118Hepatoblastoma (HP:0002884)1.75845773
119Protruding tongue (HP:0010808)1.75715509
120Bronchomalacia (HP:0002780)1.75696460
121Focal dystonia (HP:0004373)1.75113139
122Hemiplegia (HP:0002301)1.74500691
123Dysdiadochokinesis (HP:0002075)1.74445936
124Intellectual disability, severe (HP:0010864)1.74189899
125Ketosis (HP:0001946)1.72091034
126Asymmetric growth (HP:0100555)1.71192647
127Hemiparesis (HP:0001269)1.70555988
128Striae distensae (HP:0001065)1.70527768
129Disproportionate tall stature (HP:0001519)1.70158964
130Hypercortisolism (HP:0001578)1.69578330
131Genital tract atresia (HP:0001827)1.69502418
132Asymmetry of the thorax (HP:0001555)1.69270326
133Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.69054761
134Impaired vibratory sensation (HP:0002495)1.68463730
135Cortical dysplasia (HP:0002539)1.68143855
136Anxiety (HP:0000739)1.67690996
137Poor suck (HP:0002033)1.67658778
138Vaginal atresia (HP:0000148)1.67377439
139Hallux valgus (HP:0001822)1.67207818
140Papillary thyroid carcinoma (HP:0002895)1.65381139
141Fibrous tissue neoplasm (HP:0012316)1.65298464
142Deviation of the hallux (HP:0010051)1.65054071
143Abnormality of the aortic arch (HP:0012303)1.64771191
144Poor coordination (HP:0002370)1.64135049
145Paraplegia (HP:0010550)1.63722360
146Epidermoid cyst (HP:0200040)1.63463047
147Transitional cell carcinoma of the bladder (HP:0006740)1.63188183
148Poor eye contact (HP:0000817)1.63078409
149Inappropriate behavior (HP:0000719)1.62775811
150Neoplasm of the heart (HP:0100544)1.62419650
151Abnormality of glutamine family amino acid metabolism (HP:0010902)1.62152231
152Difficulty running (HP:0009046)1.62047279
153Conjunctival hamartoma (HP:0100780)1.61501990
154Renovascular hypertension (HP:0100817)1.60574208
155Myocardial infarction (HP:0001658)1.60502933
156Genetic anticipation (HP:0003743)1.60448769
157Subcapsular cataract (HP:0000523)1.60401534
158Fibroma (HP:0010614)1.60060175
159Insomnia (HP:0100785)1.59713953
160Abnormality of proline metabolism (HP:0010907)1.59160823
161Hydroxyprolinuria (HP:0003080)1.59160823
162Abnormal social behavior (HP:0012433)1.59063987
163Impaired social interactions (HP:0000735)1.59063987
164Obstructive sleep apnea (HP:0002870)1.58148661
165Hemorrhage of the eye (HP:0011885)1.57774075
166Obsessive-compulsive behavior (HP:0000722)1.56824694
167Bladder neoplasm (HP:0009725)1.55908688
168Bladder carcinoma (HP:0002862)1.55908688
169Congenital glaucoma (HP:0001087)1.55150100
170Megalencephaly (HP:0001355)1.54744873
171Hypoglycemic coma (HP:0001325)1.53785128
172Skin nodule (HP:0200036)1.51845863
173Heterotopia (HP:0002282)1.51737706
174Abnormality of oral frenula (HP:0000190)1.50809166
175Hyperactive renin-angiotensin system (HP:0000841)1.50556640
176Dilatation of the ascending aorta (HP:0005111)1.50255906
177Germ cell neoplasia (HP:0100728)1.50166301
178Intellectual disability, profound (HP:0002187)1.49061284
179Increased circulating renin level (HP:0000848)1.48593657
180Cavernous hemangioma (HP:0001048)1.48559534
181Pointed chin (HP:0000307)1.48426883

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.16134674
2TRIB34.09210249
3PKN23.18455736
4CDK193.01826249
5RIPK12.95685997
6FGFR22.22266403
7MAPK132.21579191
8MAP3K102.20120178
9EPHA42.15432818
10EEF2K2.11840251
11DYRK22.10070370
12PTK62.01510147
13PDGFRA2.00347950
14MAP3K91.97273118
15KSR21.86034449
16RET1.77418471
17MAP3K21.75977368
18MAP2K71.73367131
19PRKD31.72336840
20TNIK1.65902926
21CAMK1G1.63334832
22MARK11.61380756
23FRK1.59951317
24MARK21.57892534
25TYRO31.55635425
26SIK11.54409041
27FGFR31.47427663
28WNK41.46915524
29DAPK21.43652687
30SCYL21.40112263
31PNCK1.38754047
32KSR11.34996782
33CAMK1D1.31122180
34FGFR41.30725006
35EPHB21.29988439
36DYRK1A1.29271890
37ICK1.27892586
38LMTK21.25791961
39WNK11.21508803
40BCR1.20274724
41CAMKK11.18220645
42ERN11.17267419
43PINK11.16015611
44EPHB11.14673912
45PAK61.12694099
46SIK21.11172591
47PRKCG1.09238217
48NTRK11.05274206
49DMPK1.04382616
50SGK31.03475269
51PDGFRB1.02851011
52DYRK31.02136610
53TAOK11.01451108
54MINK11.00601210
55LRRK20.99910728
56ALK0.99814336
57PRKCH0.99239928
58TGFBR20.96039140
59MAP3K60.95162904
60CDK60.90572720
61CAMK10.89716680
62STK110.89550469
63PDK40.88384577
64PDK30.88384577
65MAP3K40.88203232
66NTRK20.87458738
67MAP2K40.86250151
68BMX0.84116248
69PRKD20.82138043
70EPHA30.80381581
71CDK140.80242878
72PTK20.79881375
73PAK30.78298247
74PDK10.76675353
75CDK11A0.76094431
76LATS10.75086821
77MAP3K70.74749022
78JAK20.74489328
79DDR20.74280459
80CDK180.74252743
81CDK150.74198039
82ERBB30.73715604
83NTRK30.72204523
84PDPK10.71910512
85STK390.69831632
86CAMK40.69607962
87PKN10.68619325
88FER0.67915994
89CAMKK20.67562132
90TRIM280.66050623
91JAK10.65809588
92SGK4940.64464525
93SGK2230.64464525
94CAMK2A0.62797401
95CDK50.62530625
96FGFR10.61901140
97DYRK1B0.61435708
98HIPK20.61107324
99MAP3K120.60571931
100STK240.59488489
101STK380.59105327
102CDK120.58160579
103CAMK2B0.57536017
104RIPK40.55968487
105MAPK120.55087838
106RPS6KA20.54461996
107SGK20.54450256
108MTOR0.54214947
109TNK20.54198406
110STK30.53864543
111PRKCZ0.53096459
112AKT30.52994654
113MAP3K10.51059257
114MAP3K110.50268670
115ERBB20.48878604
116WNK30.48369038
117UHMK10.48253379
118PRKAA10.46775151
119PRKD10.46175615
120SGK10.46113328
121GRK60.45342542
122OXSR10.45156274
123LATS20.44655538
124PLK20.44389762
125FYN0.42744262
126GSK3A0.42278748
127PRKCE0.42096126
128TESK10.41695570
129CSNK1G20.41373744
130FLT30.41333662
131SIK30.41078385
132STK100.40480136
133MAPK100.40468194
134RPS6KA30.40204321
135CSNK1A1L0.39870753
136TTN0.39651857
137PHKG20.39479882
138PHKG10.39479882
139PTK2B0.39356388
140PASK0.38790732
141CSNK1E0.38481766
142PRKG10.37744888
143PRKACA0.33961886
144GRK50.33875017
145TAOK30.33237247
146YES10.32954671
147MAPK40.32719284
148MAPK80.32433308

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.98032223
2Nitrogen metabolism_Homo sapiens_hsa009102.70796899
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.48582632
4Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61696284
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.51821857
6Serotonergic synapse_Homo sapiens_hsa047261.47982246
7Taste transduction_Homo sapiens_hsa047421.45606408
8Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.45297130
9Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.42081560
10Cardiac muscle contraction_Homo sapiens_hsa042601.41031269
11PPAR signaling pathway_Homo sapiens_hsa033201.26770646
12Bile secretion_Homo sapiens_hsa049761.23908879
13Dorso-ventral axis formation_Homo sapiens_hsa043201.22714865
14Glioma_Homo sapiens_hsa052141.21813688
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.21663366
16Type II diabetes mellitus_Homo sapiens_hsa049301.20804222
17Endometrial cancer_Homo sapiens_hsa052131.17292408
18Insulin resistance_Homo sapiens_hsa049311.15223161
19Fatty acid degradation_Homo sapiens_hsa000711.13694726
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10886189
21mTOR signaling pathway_Homo sapiens_hsa041501.10533699
22Fatty acid biosynthesis_Homo sapiens_hsa000611.10132772
23Propanoate metabolism_Homo sapiens_hsa006401.09841165
24Gastric acid secretion_Homo sapiens_hsa049711.08257629
25Long-term potentiation_Homo sapiens_hsa047201.07773087
26Estrogen signaling pathway_Homo sapiens_hsa049151.07347553
27Chronic myeloid leukemia_Homo sapiens_hsa052201.07065371
28Fatty acid metabolism_Homo sapiens_hsa012121.06562995
29Renin secretion_Homo sapiens_hsa049241.06418976
30Collecting duct acid secretion_Homo sapiens_hsa049661.04446769
31Phototransduction_Homo sapiens_hsa047441.01144555
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.99913847
33Circadian rhythm_Homo sapiens_hsa047100.99615024
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97613743
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97395381
36Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97264606
37AMPK signaling pathway_Homo sapiens_hsa041520.95532320
38Ras signaling pathway_Homo sapiens_hsa040140.95258062
39Arginine biosynthesis_Homo sapiens_hsa002200.95162600
40Adipocytokine signaling pathway_Homo sapiens_hsa049200.94310280
41Neurotrophin signaling pathway_Homo sapiens_hsa047220.93569857
42Butanoate metabolism_Homo sapiens_hsa006500.93249306
43Non-small cell lung cancer_Homo sapiens_hsa052230.92783425
44Calcium signaling pathway_Homo sapiens_hsa040200.91713537
45MAPK signaling pathway_Homo sapiens_hsa040100.90813511
46Renal cell carcinoma_Homo sapiens_hsa052110.90797431
47Dopaminergic synapse_Homo sapiens_hsa047280.90641427
48Lysine degradation_Homo sapiens_hsa003100.90632008
49VEGF signaling pathway_Homo sapiens_hsa043700.90371169
50Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90097342
51Olfactory transduction_Homo sapiens_hsa047400.88204315
52Proteoglycans in cancer_Homo sapiens_hsa052050.87718541
53Salivary secretion_Homo sapiens_hsa049700.87516363
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86839820
55Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86344048
56Thyroid hormone signaling pathway_Homo sapiens_hsa049190.85069708
57Focal adhesion_Homo sapiens_hsa045100.85051132
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84811117
59Circadian entrainment_Homo sapiens_hsa047130.84291396
60ErbB signaling pathway_Homo sapiens_hsa040120.84220721
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.84172643
62Thyroid hormone synthesis_Homo sapiens_hsa049180.84072871
63Wnt signaling pathway_Homo sapiens_hsa043100.82906428
64Pancreatic cancer_Homo sapiens_hsa052120.82804168
65Cholinergic synapse_Homo sapiens_hsa047250.82737989
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81741309
67Insulin signaling pathway_Homo sapiens_hsa049100.81513486
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81088262
69cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80733084
70Glucagon signaling pathway_Homo sapiens_hsa049220.80221816
71Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80160218
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.78769749
73Pancreatic secretion_Homo sapiens_hsa049720.78333170
74Axon guidance_Homo sapiens_hsa043600.77939335
75Regulation of autophagy_Homo sapiens_hsa041400.77745642
76Colorectal cancer_Homo sapiens_hsa052100.77110129
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76668432
78Inositol phosphate metabolism_Homo sapiens_hsa005620.76542534
79Insulin secretion_Homo sapiens_hsa049110.76139634
80Glutamatergic synapse_Homo sapiens_hsa047240.75107997
81Adherens junction_Homo sapiens_hsa045200.74644411
82Oocyte meiosis_Homo sapiens_hsa041140.74297861
83GnRH signaling pathway_Homo sapiens_hsa049120.72161761
842-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70095664
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67901389
86Gap junction_Homo sapiens_hsa045400.67823556
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67540220
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.67520609
89Prolactin signaling pathway_Homo sapiens_hsa049170.67355346
90Oxytocin signaling pathway_Homo sapiens_hsa049210.67222632
91Amoebiasis_Homo sapiens_hsa051460.66522153
92cAMP signaling pathway_Homo sapiens_hsa040240.65922305
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65677326
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65523128
95GABAergic synapse_Homo sapiens_hsa047270.65062364
96B cell receptor signaling pathway_Homo sapiens_hsa046620.65021918
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64941803
98Notch signaling pathway_Homo sapiens_hsa043300.63405463
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.63218674
100Vibrio cholerae infection_Homo sapiens_hsa051100.62540571
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62004854
102Endocytosis_Homo sapiens_hsa041440.61963076
103Melanogenesis_Homo sapiens_hsa049160.61841690
104Leukocyte transendothelial migration_Homo sapiens_hsa046700.61661607
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61442345
106Tryptophan metabolism_Homo sapiens_hsa003800.61281863
107Amphetamine addiction_Homo sapiens_hsa050310.60635866
108Choline metabolism in cancer_Homo sapiens_hsa052310.60153152
109Hedgehog signaling pathway_Homo sapiens_hsa043400.60024445
110Morphine addiction_Homo sapiens_hsa050320.59860059
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59790045
112Cocaine addiction_Homo sapiens_hsa050300.59448096
113Osteoclast differentiation_Homo sapiens_hsa043800.59404807
114Synaptic vesicle cycle_Homo sapiens_hsa047210.58896863
115Toxoplasmosis_Homo sapiens_hsa051450.58857064
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58598516
117Platelet activation_Homo sapiens_hsa046110.58587528
118Chemokine signaling pathway_Homo sapiens_hsa040620.57999240
119Hippo signaling pathway_Homo sapiens_hsa043900.57906872
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.57794890
121Rap1 signaling pathway_Homo sapiens_hsa040150.56663281
122Long-term depression_Homo sapiens_hsa047300.56525386
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56514584
124FoxO signaling pathway_Homo sapiens_hsa040680.56276273
125Vascular smooth muscle contraction_Homo sapiens_hsa042700.53817215
126Alcoholism_Homo sapiens_hsa050340.52579304
127Dilated cardiomyopathy_Homo sapiens_hsa054140.49724518
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.49073600
129Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46495677
130Alzheimers disease_Homo sapiens_hsa050100.45317238
131Basal cell carcinoma_Homo sapiens_hsa052170.44847183
132Parkinsons disease_Homo sapiens_hsa050120.43718885
133Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40235814
134Ovarian steroidogenesis_Homo sapiens_hsa049130.37259071
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35877863
136Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35855111
137Oxidative phosphorylation_Homo sapiens_hsa001900.34157399

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