CCNG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The protein encoded by this gene is a member of the cyclin family and contains the cyclin box. The encoded protein lacks the protein destabilizing (PEST) sequence that is present in other family members. Transcriptional activation of this gene can be induced by tumor protein p53. Two transcript variants encoding the same protein have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)5.83047321
2sarcomere organization (GO:0045214)5.79334032
3actin-myosin filament sliding (GO:0033275)5.31103419
4muscle filament sliding (GO:0030049)5.31103419
5regulation of skeletal muscle contraction (GO:0014819)5.01676205
6positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.81403346
7chromatin remodeling at centromere (GO:0031055)4.80217151
8CENP-A containing nucleosome assembly (GO:0034080)4.78125482
9negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.60705947
10actin-mediated cell contraction (GO:0070252)4.51815297
11establishment of integrated proviral latency (GO:0075713)4.44041547
12nuclear pore complex assembly (GO:0051292)4.43621712
13protein localization to kinetochore (GO:0034501)4.39918516
14cardiac myofibril assembly (GO:0055003)4.36364906
15nuclear pore organization (GO:0006999)4.14207110
16histone exchange (GO:0043486)3.98303560
17myofibril assembly (GO:0030239)3.93400006
18epithelial cell-cell adhesion (GO:0090136)3.91420834
19DNA replication-independent nucleosome organization (GO:0034724)3.88924715
20DNA replication-independent nucleosome assembly (GO:0006336)3.88924715
21tricarboxylic acid cycle (GO:0006099)3.88516504
22DNA ligation (GO:0006266)3.84664667
23protein hydroxylation (GO:0018126)3.83807888
24actomyosin structure organization (GO:0031032)3.83478826
25protein localization to chromosome, centromeric region (GO:0071459)3.81532476
26negative regulation of potassium ion transmembrane transport (GO:1901380)3.79571071
27mitotic metaphase plate congression (GO:0007080)3.77874267
28regulation of tight junction assembly (GO:2000810)3.76427909
29regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.73365032
30negative regulation of sister chromatid segregation (GO:0033046)3.69643316
31negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.69643316
32negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.69643316
33negative regulation of mitotic sister chromatid segregation (GO:0033048)3.69643316
34negative regulation of mitotic sister chromatid separation (GO:2000816)3.69643316
35IMP biosynthetic process (GO:0006188)3.68121221
36peptidyl-proline hydroxylation (GO:0019511)3.67316719
37actin filament-based movement (GO:0030048)3.67156726
38cell adhesion mediated by integrin (GO:0033627)3.66979284
39spindle checkpoint (GO:0031577)3.66772073
40negative regulation of chromosome segregation (GO:0051985)3.65761851
41regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.65271257
42chondrocyte proliferation (GO:0035988)3.64671381
43L-serine metabolic process (GO:0006563)3.63535851
44mitotic spindle checkpoint (GO:0071174)3.63504987
45purine nucleobase biosynthetic process (GO:0009113)3.62621493
46sister chromatid segregation (GO:0000819)3.61935892
47DNA replication checkpoint (GO:0000076)3.53736772
48double-strand break repair via nonhomologous end joining (GO:0006303)3.52261292
49non-recombinational repair (GO:0000726)3.52261292
50DNA strand elongation involved in DNA replication (GO:0006271)3.51798277
51mitotic sister chromatid segregation (GO:0000070)3.50855514
52negative regulation of fatty acid transport (GO:2000192)3.50262964
53regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.50005537
54DNA unwinding involved in DNA replication (GO:0006268)3.49740012
55endodermal cell differentiation (GO:0035987)3.47794929
56formation of translation preinitiation complex (GO:0001731)3.47683490
57mitotic spindle assembly checkpoint (GO:0007094)3.44847049
58metaphase plate congression (GO:0051310)3.43194680
59cardiac muscle cell development (GO:0055013)3.42498380
60regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.41400132
61regulation of mitotic metaphase/anaphase transition (GO:0030071)3.41400132
62spindle assembly checkpoint (GO:0071173)3.40630504
63carnitine shuttle (GO:0006853)3.39096707
64hippo signaling (GO:0035329)3.38328428
65DNA replication-dependent nucleosome organization (GO:0034723)3.38203252
66DNA replication-dependent nucleosome assembly (GO:0006335)3.38203252
67pre-miRNA processing (GO:0031054)3.38049872
68regulation of chromosome segregation (GO:0051983)3.34593720
69kinetochore organization (GO:0051383)3.34085563
70regulation of mitotic sister chromatid separation (GO:0010965)3.34054532
71regulation of mitotic sister chromatid segregation (GO:0033047)3.34054532
72regulation of sister chromatid segregation (GO:0033045)3.34054532
73DNA strand elongation (GO:0022616)3.33959187
74regulation of centriole replication (GO:0046599)3.33578983
75regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.31866682
76regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.30249705
77DNA double-strand break processing (GO:0000729)3.28660980
78regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.28565914
79DNA topological change (GO:0006265)3.24117869
80telomere maintenance via semi-conservative replication (GO:0032201)3.23615696
81cardiac muscle contraction (GO:0060048)3.23137719
82cardiac cell development (GO:0055006)3.23014247
83establishment of viral latency (GO:0019043)3.22556038
84cellular response to vitamin (GO:0071295)3.22254378
85regulation of SMAD protein import into nucleus (GO:0060390)3.20142027
86regulation of helicase activity (GO:0051095)3.19720772
87adherens junction assembly (GO:0034333)3.17434559
88positive regulation of SMAD protein import into nucleus (GO:0060391)3.17020191
89cell-substrate junction assembly (GO:0007044)3.15639990
90heterochromatin organization (GO:0070828)3.15474754
91ATP-dependent chromatin remodeling (GO:0043044)3.14860351
92regulation of cofactor metabolic process (GO:0051193)3.13159918
93regulation of coenzyme metabolic process (GO:0051196)3.13159918
94regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.10655804
95regulation of mitotic spindle checkpoint (GO:1903504)3.10655804
96mitotic recombination (GO:0006312)3.10535168
97regulation of acyl-CoA biosynthetic process (GO:0050812)3.10117974
98negative regulation of cell size (GO:0045792)3.10026621
99collagen fibril organization (GO:0030199)3.09826521
100nucleobase biosynthetic process (GO:0046112)3.09292667
101pore complex assembly (GO:0046931)3.09276408
102cell migration involved in sprouting angiogenesis (GO:0002042)3.06632694
103ribosome assembly (GO:0042255)3.06338118
104COPI coating of Golgi vesicle (GO:0048205)3.02993540
105Golgi transport vesicle coating (GO:0048200)3.02993540
106mitotic nuclear envelope disassembly (GO:0007077)3.00904364
107polarized epithelial cell differentiation (GO:0030859)2.99441577
108focal adhesion assembly (GO:0048041)2.97046895
109cell-substrate adherens junction assembly (GO:0007045)2.97046895
110negative regulation of mitosis (GO:0045839)2.95280666
111fatty acid transmembrane transport (GO:1902001)2.95270500
112basement membrane organization (GO:0071711)2.95025855
113kinetochore assembly (GO:0051382)2.94485620
114telomere maintenance via recombination (GO:0000722)2.92507061
115mitotic chromosome condensation (GO:0007076)2.92359233
116regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.92214578
117regulation of hippo signaling (GO:0035330)2.91996146
118sarcoplasmic reticulum calcium ion transport (GO:0070296)2.90641451
119anterior/posterior axis specification, embryo (GO:0008595)2.90514768
120regulation of sister chromatid cohesion (GO:0007063)2.89055076
121positive regulation of endothelial cell apoptotic process (GO:2000353)2.88033749
122mitotic sister chromatid cohesion (GO:0007064)2.87875976
123regulation of relaxation of muscle (GO:1901077)2.87576219
124apoptotic cell clearance (GO:0043277)2.87170339
125somatic diversification of immune receptors via somatic mutation (GO:0002566)2.85544620
126somatic hypermutation of immunoglobulin genes (GO:0016446)2.85544620
127* mitotic G2/M transition checkpoint (GO:0044818)2.85387790
1284-hydroxyproline metabolic process (GO:0019471)2.85353427
129apoptotic process involved in morphogenesis (GO:0060561)2.85044694
130negative regulation of cardiac muscle tissue growth (GO:0055022)2.84791071
131negative regulation of heart growth (GO:0061117)2.84791071
132bundle of His cell to Purkinje myocyte communication (GO:0086069)2.83591842
133establishment of chromosome localization (GO:0051303)2.83202631
134endocardial cushion development (GO:0003197)2.83112541
135regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.81962630
136DNA strand renaturation (GO:0000733)2.77760126
137DNA damage response, detection of DNA damage (GO:0042769)2.77384186
138regulation of gene silencing by RNA (GO:0060966)2.76611347
139regulation of posttranscriptional gene silencing (GO:0060147)2.76611347
140regulation of gene silencing by miRNA (GO:0060964)2.76611347
141cellular response to vitamin D (GO:0071305)2.76377043
142chromatin assembly or disassembly (GO:0006333)2.75910848
143nuclear envelope disassembly (GO:0051081)2.75723364
144membrane disassembly (GO:0030397)2.75723364
145wound healing, spreading of epidermal cells (GO:0035313)2.73041654
146negative regulation of DNA recombination (GO:0045910)2.71684182
147striated muscle contraction (GO:0006941)2.70935300
148regulation of mitotic spindle organization (GO:0060236)2.70076985
149cardiac muscle tissue morphogenesis (GO:0055008)2.69616419
150cellular response to interferon-alpha (GO:0035457)2.68912872
151cullin deneddylation (GO:0010388)2.68314972
152NLS-bearing protein import into nucleus (GO:0006607)2.68302408
153protein complex localization (GO:0031503)2.67983530
154positive regulation of blood vessel endothelial cell migration (GO:0043536)2.67592659
155regulation of cell communication by electrical coupling (GO:0010649)2.67368611
156paraxial mesoderm development (GO:0048339)2.66521526
157negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.66431614
158cellular response to nutrient (GO:0031670)2.65528647
159stress fiber assembly (GO:0043149)2.64881526
160negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.64460625
161substrate adhesion-dependent cell spreading (GO:0034446)2.64342326
162protein neddylation (GO:0045116)2.63263828
163tRNA aminoacylation for protein translation (GO:0006418)2.62791843
164regulation of centrosome cycle (GO:0046605)2.62640196
165skeletal muscle adaptation (GO:0043501)2.62625645
166ribosomal small subunit assembly (GO:0000028)2.62473878
167heart trabecula formation (GO:0060347)2.62406211
168chromosome segregation (GO:0007059)2.62349161
169vascular endothelial growth factor signaling pathway (GO:0038084)2.61963536
170negative regulation of DNA-dependent DNA replication (GO:2000104)2.61432386
171proteasome assembly (GO:0043248)2.60185208
172response to X-ray (GO:0010165)2.59969487
173desmosome organization (GO:0002934)2.58665212
174skeletal muscle tissue regeneration (GO:0043403)2.57420460
175amino acid activation (GO:0043038)2.57361535
176tRNA aminoacylation (GO:0043039)2.57361535
177ribosomal large subunit biogenesis (GO:0042273)2.57145444
178negative regulation of nuclear division (GO:0051784)2.56019829
179protein localization to endosome (GO:0036010)2.55855542
180regulation of actin filament-based movement (GO:1903115)2.55376520
181regulation of translational fidelity (GO:0006450)2.54796640
182regulation of cell fate specification (GO:0042659)2.54559038
183negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.54365683
184regulation of cardioblast differentiation (GO:0051890)2.53961151
185IMP metabolic process (GO:0046040)2.53860685
186hemidesmosome assembly (GO:0031581)2.53645511
187muscle contraction (GO:0006936)2.51090463
188creatine metabolic process (GO:0006600)2.47831157
189regulation of translational termination (GO:0006449)2.47133575
190muscle tissue morphogenesis (GO:0060415)2.45812674
191regulation of sulfur metabolic process (GO:0042762)2.45772522
192tricarboxylic acid metabolic process (GO:0072350)2.44374731
193renal filtration (GO:0097205)2.42476358
194ventricular cardiac muscle cell development (GO:0055015)2.42139593
195protein heterotrimerization (GO:0070208)2.41351534
196blood vessel endothelial cell migration (GO:0043534)2.39393736
197actin filament depolymerization (GO:0030042)2.37264280

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.34458589
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.50676431
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.26198723
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.07532143
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.83111696
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.49044822
7EGR1_19374776_ChIP-ChIP_THP-1_Human3.13259285
8CLOCK_20551151_ChIP-Seq_293T_Human3.11831261
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.05343589
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.96076417
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90914246
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.63906245
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63724511
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.62438726
15* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.59160262
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.54061401
17RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.38793026
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.31317467
19NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.26335374
20HIF1A_21447827_ChIP-Seq_MCF-7_Human2.24008245
21SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.21474601
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.14047955
23ZNF263_19887448_ChIP-Seq_K562_Human2.13215877
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09165569
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02094721
26RBPJ_22232070_ChIP-Seq_NCS_Mouse2.01664589
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98639774
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.97954539
29NANOG_16153702_ChIP-ChIP_HESCs_Human1.96009810
30PADI4_21655091_ChIP-ChIP_MCF-7_Human1.95711416
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.95109149
32SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.93607724
33KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.92256323
34KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.92256323
35KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.92256323
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.91209254
37STAT3_1855785_ChIP-Seq_MESCs_Mouse1.91152971
38ATF3_27146783_Chip-Seq_COLON_Human1.89947190
39TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.89395109
40ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.88741835
41POU5F1_16153702_ChIP-ChIP_HESCs_Human1.88181713
42* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.88156306
43SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.87524537
44SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.87524537
45PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.86133569
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.84876406
47TBX20_22080862_ChIP-Seq_HEART_Mouse1.83859126
48TBX20_22328084_ChIP-Seq_HEART_Mouse1.83859126
49KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.82841849
50* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82749421
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.82719784
52* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82621893
53EWS_26573619_Chip-Seq_HEK293_Human1.80996384
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77535206
55YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75484704
56NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.74799910
57FOXM1_23109430_ChIP-Seq_U2OS_Human1.74633073
58* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74500434
59CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.73518867
60MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.73049981
61SOX2_16153702_ChIP-ChIP_HESCs_Human1.72050010
62* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71846163
63FOXP3_21729870_ChIP-Seq_TREG_Human1.70947384
64FUS_26573619_Chip-Seq_HEK293_Human1.68332925
65BRD4_25478319_ChIP-Seq_HGPS_Human1.68265040
66* TTF2_22483619_ChIP-Seq_HELA_Human1.63174213
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.62740153
68* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60110845
69VDR_23849224_ChIP-Seq_CD4+_Human1.59349684
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.59237409
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57437474
72* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.57292433
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.56909890
74ESR1_15608294_ChIP-ChIP_MCF-7_Human1.56444183
75SALL4_18804426_ChIP-ChIP_XEN_Mouse1.55847085
76DCP1A_22483619_ChIP-Seq_HELA_Human1.55806045
77ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.55120649
78FOXO3_23340844_ChIP-Seq_DLD1_Human1.54549319
79MYC_18555785_ChIP-Seq_MESCs_Mouse1.52994718
80* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50214146
81CJUN_26792858_Chip-Seq_BT549_Human1.50123431
82SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.50022207
83JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48065147
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.47959003
85SOX2_18555785_ChIP-Seq_MESCs_Mouse1.47642258
86AR_21909140_ChIP-Seq_LNCAP_Human1.46586084
87THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45671625
88XRN2_22483619_ChIP-Seq_HELA_Human1.45306886
89P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44811975
90SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.44413581
91* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43293983
92TCF3_18692474_ChIP-Seq_MEFs_Mouse1.42858413
93SALL1_21062744_ChIP-ChIP_HESCs_Human1.42113131
94* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.40817716
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.40684383
96MYC_18940864_ChIP-ChIP_HL60_Human1.40071433
97POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.36461059
98UBF1/2_26484160_Chip-Seq_HMECs_Human1.35878835
99EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.34483916
100E2F7_22180533_ChIP-Seq_HELA_Human1.31512616
101TFEB_21752829_ChIP-Seq_HELA_Human1.31429666
102* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28827939
103ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28386600
104ESR1_20079471_ChIP-ChIP_T-47D_Human1.28375361
105NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.28176091
106TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27570286
107ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.27369264
108* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.27100204
109NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26462123
110MYC_22102868_ChIP-Seq_BL_Human1.25804987
111ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.25656941
112IGF1R_20145208_ChIP-Seq_DFB_Human1.24899181
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24220798
114WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23178399
115SOX17_20123909_ChIP-Seq_XEN_Mouse1.22867664
116FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.22700076
117FLI1_27457419_Chip-Seq_LIVER_Mouse1.22630800
118ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.21782706
119CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.21458780
120KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21063864
121TP63_19390658_ChIP-ChIP_HaCaT_Human1.16537640
122NANOG_21062744_ChIP-ChIP_HESCs_Human1.15959950
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15715989
124NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15715989
125JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15408199
126KLF4_18555785_ChIP-Seq_MESCs_Mouse1.15254253
127* TP53_22127205_ChIP-Seq_IMR90_Human1.15142827
128FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.12867392
129GABP_19822575_ChIP-Seq_HepG2_Human1.12794030
130* TP53_23651856_ChIP-Seq_MEFs_Mouse1.12758270
131EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.11912515
132ZFX_18555785_ChIP-Seq_MESCs_Mouse1.11807378
133* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.11703161
134CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10881038
135ESR1_21235772_ChIP-Seq_MCF-7_Human1.10536748
136IRF1_19129219_ChIP-ChIP_H3396_Human1.10249693
137RACK7_27058665_Chip-Seq_MCF-7_Human1.09797373
138CHD1_26751641_Chip-Seq_LNCaP_Human1.08271680
139TAF15_26573619_Chip-Seq_HEK293_Human1.08089161
140* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.07419382
141SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07117947
142ESR2_21235772_ChIP-Seq_MCF-7_Human1.06418111
143NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06165561
144P300_19829295_ChIP-Seq_ESCs_Human1.05777605
145TP53_16413492_ChIP-PET_HCT116_Human1.05732514
146TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.05670601
147JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05193085
148KDM2B_26808549_Chip-Seq_DND41_Human1.04036495
149ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02916050
150HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02042605
151RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01949485
152SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01469087
153KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00636893
154SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00254257
155ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99812641
156ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99180983
157HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.99034668
158SRF_21415370_ChIP-Seq_HL-1_Mouse0.98976916
159TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98892347
160ELK1_19687146_ChIP-ChIP_HELA_Human0.98557129
161CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97477028
162ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95776471
163DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94928885
164NCOR1_26117541_ChIP-Seq_K562_Human0.93710373
165KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93582597
166* HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93027478
167E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92567945
168SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92294141
169NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.89982133
170NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88173041
171ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86999669
172PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86873279
173CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84479889
174FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.84415901
175ERG_20887958_ChIP-Seq_HPC-7_Mouse0.84309014
176KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.83821642
177VDR_22108803_ChIP-Seq_LS180_Human0.80655556
178ZNF274_21170338_ChIP-Seq_K562_Hela0.80113966
179CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.80013770
180TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.78457778

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.14863994
2MP0003705_abnormal_hypodermis_morpholog3.68403080
3MP0004084_abnormal_cardiac_muscle3.55708615
4MP0004957_abnormal_blastocyst_morpholog3.45920658
5MP0010094_abnormal_chromosome_stability3.36599222
6MP0003890_abnormal_embryonic-extraembry3.36116725
7MP0003693_abnormal_embryo_hatching3.02379584
8MP0010352_gastrointestinal_tract_polyps2.87335027
9MP0002837_dystrophic_cardiac_calcinosis2.83624944
10MP0000751_myopathy2.80558597
11MP0005275_abnormal_skin_tensile2.78965943
12MP0003111_abnormal_nucleus_morphology2.77404396
13MP0008932_abnormal_embryonic_tissue2.72068803
14MP0008057_abnormal_DNA_replication2.64599334
15MP0005623_abnormal_meninges_morphology2.62346001
16MP0000749_muscle_degeneration2.62069991
17MP0001293_anophthalmia2.61701454
18MP0008058_abnormal_DNA_repair2.57075936
19MP0000750_abnormal_muscle_regeneration2.53039644
20MP0003077_abnormal_cell_cycle2.50115923
21MP0004036_abnormal_muscle_relaxation2.44073209
22MP0006292_abnormal_olfactory_placode2.37327135
23MP0004087_abnormal_muscle_fiber2.37231845
24MP0003646_muscle_fatigue2.29561968
25MP0003566_abnormal_cell_adhesion2.26517740
26MP0009697_abnormal_copulation2.24804744
27MP0004130_abnormal_muscle_cell2.15086693
28MP0005330_cardiomyopathy2.14562620
29MP0003136_yellow_coat_color2.11104097
30MP0003279_aneurysm2.08426138
31MP0004215_abnormal_myocardial_fiber2.04379101
32MP0003937_abnormal_limbs/digits/tail_de2.01745985
33MP0000733_abnormal_muscle_development2.00550715
34MP0002269_muscular_atrophy1.95505200
35MP0000747_muscle_weakness1.93879885
36MP0004233_abnormal_muscle_weight1.92814021
37MP0005503_abnormal_tendon_morphology1.87814481
38MP0002938_white_spotting1.86749909
39MP0010630_abnormal_cardiac_muscle1.86318517
40MP0008007_abnormal_cellular_replicative1.85878138
41MP0008775_abnormal_heart_ventricle1.84581218
42MP0009672_abnormal_birth_weight1.83753259
43MP0003119_abnormal_digestive_system1.82379739
44MP0002106_abnormal_muscle_physiology1.80240988
45MP0002254_reproductive_system_inflammat1.78902688
46MP0004272_abnormal_basement_membrane1.78414913
47MP0000759_abnormal_skeletal_muscle1.76832173
48MP0005620_abnormal_muscle_contractility1.75826735
49MP0003718_maternal_effect1.72398606
50MP0002697_abnormal_eye_size1.71164169
51MP0002972_abnormal_cardiac_muscle1.69492690
52MP0002085_abnormal_embryonic_tissue1.63059369
53MP0001286_abnormal_eye_development1.61514772
54MP0009384_cardiac_valve_regurgitation1.61018476
55MP0003091_abnormal_cell_migration1.59875255
56MP0003300_gastrointestinal_ulcer1.59754199
57MP0010234_abnormal_vibrissa_follicle1.59736183
58MP0002877_abnormal_melanocyte_morpholog1.59384033
59MP0002233_abnormal_nose_morphology1.58258543
60MP0001544_abnormal_cardiovascular_syste1.56846915
61MP0005385_cardiovascular_system_phenoty1.56846915
62MP0001529_abnormal_vocalization1.54918429
63MP0005369_muscle_phenotype1.54083218
64MP0004145_abnormal_muscle_electrophysio1.53986520
65MP0002102_abnormal_ear_morphology1.53653407
66MP0005023_abnormal_wound_healing1.53240091
67MP0001958_emphysema1.52514491
68MP0004185_abnormal_adipocyte_glucose1.44141035
69MP0004484_altered_response_of1.40159047
70MP0003221_abnormal_cardiomyocyte_apopto1.39435096
71MP0005666_abnormal_adipose_tissue1.38945397
72MP0005076_abnormal_cell_differentiation1.37990797
73MP0003122_maternal_imprinting1.37168890
74MP0006138_congestive_heart_failure1.36560745
75MP0003941_abnormal_skin_development1.35445391
76MP0004133_heterotaxia1.35046190
77MP0002111_abnormal_tail_morphology1.33891114
78MP0003950_abnormal_plasma_membrane1.32492321
79MP0010307_abnormal_tumor_latency1.32184845
80MP0005394_taste/olfaction_phenotype1.31184690
81MP0005499_abnormal_olfactory_system1.31184690
82MP0009703_decreased_birth_body1.30867775
83MP0003828_pulmonary_edema1.25283636
84MP0002080_prenatal_lethality1.24833827
85MP0006054_spinal_hemorrhage1.23941981
86MP0003567_abnormal_fetal_cardiomyocyte1.22090579
87MP0003806_abnormal_nucleotide_metabolis1.21529845
88MP0008789_abnormal_olfactory_epithelium1.20994118
89MP0008877_abnormal_DNA_methylation1.17785554
90MP0000372_irregular_coat_pigmentation1.15333110
91MP0000013_abnormal_adipose_tissue1.14723873
92MP0002092_abnormal_eye_morphology1.14323791
93MP0004147_increased_porphyrin_level1.14109092
94MP0002108_abnormal_muscle_morphology1.12448729
95MP0003121_genomic_imprinting1.11895911
96MP0005375_adipose_tissue_phenotype1.10128024
97MP0000049_abnormal_middle_ear1.08775562
98MP0003315_abnormal_perineum_morphology1.06499445
99MP0001299_abnormal_eye_distance/1.06464549
100MP0000343_altered_response_to1.04736434
101MP0002896_abnormal_bone_mineralization1.04133687
102MP0000266_abnormal_heart_morphology1.01881978
103MP0005248_abnormal_Harderian_gland0.98937696
104MP0006035_abnormal_mitochondrial_morpho0.96580110
105MP0003137_abnormal_impulse_conducting0.95927832
106MP0003755_abnormal_palate_morphology0.94733538
107MP0010030_abnormal_orbit_morphology0.93391913
108MP0004197_abnormal_fetal_growth/weight/0.91584013
109MP0000003_abnormal_adipose_tissue0.91578452
110MP0002128_abnormal_blood_circulation0.90807164
111MP0003984_embryonic_growth_retardation0.89919152
112MP0002234_abnormal_pharynx_morphology0.89476760
113MP0002088_abnormal_embryonic_growth/wei0.88939634
114MP0002060_abnormal_skin_morphology0.88859940
115MP0009053_abnormal_anal_canal0.88294395
116MP0000428_abnormal_craniofacial_morphol0.88282496
117MP0003935_abnormal_craniofacial_develop0.87453293
118MP0001348_abnormal_lacrimal_gland0.87274290
119MP0003861_abnormal_nervous_system0.86759415
120MP0003045_fibrosis0.85519963
121MP0005508_abnormal_skeleton_morphology0.85482985
122MP0000767_abnormal_smooth_muscle0.85189568
123MP0000432_abnormal_head_morphology0.85111940
124MP0003786_premature_aging0.84245788
125MP0001188_hyperpigmentation0.83002465
126MP0003186_abnormal_redox_activity0.82694430
127MP0006072_abnormal_retinal_apoptosis0.82480139
128MP0005187_abnormal_penis_morphology0.82384177
129MP0000358_abnormal_cell_content/0.82090264
130MP0002332_abnormal_exercise_endurance0.81762865
131MP0000647_abnormal_sebaceous_gland0.81437669
132MP0004808_abnormal_hematopoietic_stem0.81042855
133* MP0000313_abnormal_cell_death0.80746491
134MP0002009_preneoplasia0.80304246
135MP0002925_abnormal_cardiovascular_devel0.79869389
136MP0002090_abnormal_vision0.79723008
137MP0009780_abnormal_chondrocyte_physiolo0.78665897
138MP0001730_embryonic_growth_arrest0.78652487
139MP0005391_vision/eye_phenotype0.78438213
140MP0001661_extended_life_span0.78278213
141MP0000858_altered_metastatic_potential0.78058551
142MP0000516_abnormal_urinary_system0.77875325
143MP0005367_renal/urinary_system_phenotyp0.77875325
144MP0003385_abnormal_body_wall0.77444849
145MP0010368_abnormal_lymphatic_system0.76729446
146MP0005380_embryogenesis_phenotype0.76321065
147MP0001672_abnormal_embryogenesis/_devel0.76321065
148MP0002086_abnormal_extraembryonic_tissu0.76007245
149MP0001915_intracranial_hemorrhage0.75684617
150MP0004264_abnormal_extraembryonic_tissu0.75306826
151MP0003942_abnormal_urinary_system0.75046244
152MP0005165_increased_susceptibility_to0.74835035
153MP0002084_abnormal_developmental_patter0.74503858
154MP0002295_abnormal_pulmonary_circulatio0.74495656
155MP0001177_atelectasis0.71721237
156MP0001697_abnormal_embryo_size0.71335027
157MP0002089_abnormal_postnatal_growth/wei0.70565096
158MP0002751_abnormal_autonomic_nervous0.70106467
159MP0001614_abnormal_blood_vessel0.70097403
160MP0002168_other_aberrant_phenotype0.69974492
161MP0001145_abnormal_male_reproductive0.69338539
162MP0005670_abnormal_white_adipose0.68981540
163MP0000537_abnormal_urethra_morphology0.66858343
164MP0002210_abnormal_sex_determination0.66373290
165MP0001324_abnormal_eye_pigmentation0.65921091
166MP0000653_abnormal_sex_gland0.65802236
167MP0000350_abnormal_cell_proliferation0.64780481
168MP0003453_abnormal_keratinocyte_physiol0.63818035
169MP0001929_abnormal_gametogenesis0.62088253
170MP0001849_ear_inflammation0.61405584
171MP0005171_absent_coat_pigmentation0.60877522
172MP0009250_abnormal_appendicular_skeleto0.60503805
173MP0002081_perinatal_lethality0.57909445

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)5.20511255
2Protrusio acetabuli (HP:0003179)4.89239870
3Increased connective tissue (HP:0009025)4.48027152
4Muscle fiber splitting (HP:0003555)4.44102030
5Hyporeflexia of lower limbs (HP:0002600)4.34603228
6Premature rupture of membranes (HP:0001788)4.19581558
7Exercise-induced myalgia (HP:0003738)4.03134502
8Right ventricular cardiomyopathy (HP:0011663)4.02782868
9Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.01306569
10Sudden death (HP:0001699)3.99286422
11Muscle fiber inclusion bodies (HP:0100299)3.98185939
12Ventricular tachycardia (HP:0004756)3.94026551
13Type 1 muscle fiber predominance (HP:0003803)3.89981230
14Myoglobinuria (HP:0002913)3.75728055
15Calf muscle hypertrophy (HP:0008981)3.56684876
16Difficulty running (HP:0009046)3.55379252
17Difficulty climbing stairs (HP:0003551)3.47940402
18Muscle hypertrophy of the lower extremities (HP:0008968)3.39993380
19Nemaline bodies (HP:0003798)3.37289580
20Abnormality of the calf musculature (HP:0001430)3.34563479
21Colon cancer (HP:0003003)3.26467175
22Ankle contracture (HP:0006466)3.22378256
23EMG: myopathic abnormalities (HP:0003458)3.19989284
24Nephroblastoma (Wilms tumor) (HP:0002667)3.19182939
25Distal arthrogryposis (HP:0005684)3.19134573
26Chromsome breakage (HP:0040012)3.18549800
27Chromosomal breakage induced by crosslinking agents (HP:0003221)3.16769335
28Abnormal lung lobation (HP:0002101)3.16481928
29Cerebral aneurysm (HP:0004944)3.15756438
30Round ear (HP:0100830)3.13559778
31Rhabdomyolysis (HP:0003201)3.11939144
32Embryonal renal neoplasm (HP:0011794)3.10875311
33Lipoatrophy (HP:0100578)3.05503437
34Shallow orbits (HP:0000586)3.04978873
35Septo-optic dysplasia (HP:0100842)3.00392285
36Cervical subluxation (HP:0003308)2.94507277
37Hyperglycinemia (HP:0002154)2.94398463
38Aortic aneurysm (HP:0004942)2.89710310
39Pancreatic islet-cell hyperplasia (HP:0004510)2.87770350
40Abnormality of the labia minora (HP:0012880)2.84080129
41Meckel diverticulum (HP:0002245)2.83580070
42Atrial fibrillation (HP:0005110)2.80561158
43Distal lower limb muscle weakness (HP:0009053)2.78974017
44Spinal rigidity (HP:0003306)2.78784977
45Subaortic stenosis (HP:0001682)2.78494429
46Abnormality of the left ventricular outflow tract (HP:0011103)2.78494429
47Ulnar deviation of the wrist (HP:0003049)2.75766707
48Cortical dysplasia (HP:0002539)2.74296817
49Abnormality of methionine metabolism (HP:0010901)2.74119427
50Aortic dissection (HP:0002647)2.71038451
51Scapular winging (HP:0003691)2.69430222
52Abnormality of chromosome stability (HP:0003220)2.68711406
53Abnormality of the ileum (HP:0001549)2.68551629
54Increased variability in muscle fiber diameter (HP:0003557)2.67448669
55Abnormality of skeletal muscle fiber size (HP:0012084)2.66035435
56Asymmetric septal hypertrophy (HP:0001670)2.64884186
57Primary atrial arrhythmia (HP:0001692)2.64128503
58Broad metatarsal (HP:0001783)2.60846958
59Myopathic facies (HP:0002058)2.59507713
60Increased density of long bones (HP:0006392)2.58574799
61Supraventricular arrhythmia (HP:0005115)2.55982988
62Aplasia/Hypoplasia of the uvula (HP:0010293)2.51955848
63Stenosis of the external auditory canal (HP:0000402)2.51244589
64Supraventricular tachycardia (HP:0004755)2.50943808
65Bifid tongue (HP:0010297)2.49365769
66Hypoplastic ischia (HP:0003175)2.48189371
67Atrophic scars (HP:0001075)2.47684208
68Reticulocytopenia (HP:0001896)2.47500448
69Frequent falls (HP:0002359)2.47081393
70Dilatation of the ascending aorta (HP:0005111)2.45237244
71Abnormality of the calcaneus (HP:0008364)2.45167532
72Myotonia (HP:0002486)2.45002043
73Abnormality of serine family amino acid metabolism (HP:0010894)2.44271279
74Abnormality of glycine metabolism (HP:0010895)2.44271279
75Abnormality of aspartate family amino acid metabolism (HP:0010899)2.40077774
76Wrist flexion contracture (HP:0001239)2.39997399
77Dilated cardiomyopathy (HP:0001644)2.39837794
78Hyperglycinuria (HP:0003108)2.37632353
79Aneurysm (HP:0002617)2.35453243
80Rhabdomyosarcoma (HP:0002859)2.34715884
81Distal lower limb amyotrophy (HP:0008944)2.32557611
82Hepatoblastoma (HP:0002884)2.31408334
83Abnormality of serum amino acid levels (HP:0003112)2.31116289
84Increased serum pyruvate (HP:0003542)2.29524113
85Birth length less than 3rd percentile (HP:0003561)2.28177021
86Small intestinal stenosis (HP:0012848)2.26161520
87Duodenal stenosis (HP:0100867)2.26161520
88Spastic diplegia (HP:0001264)2.26021125
89Neoplasm of the colon (HP:0100273)2.25281774
90Intestinal atresia (HP:0011100)2.24532857
91Limb-girdle muscle atrophy (HP:0003797)2.24226746
92Abnormality of the duodenum (HP:0002246)2.21948968
93Abnormality of glycolysis (HP:0004366)2.20646301
94Muscle stiffness (HP:0003552)2.18014719
95Calcaneovalgus deformity (HP:0001848)2.16657589
96Mildly elevated creatine phosphokinase (HP:0008180)2.15466073
97Triphalangeal thumb (HP:0001199)2.15209222
98Peritonitis (HP:0002586)2.14936468
99Increased nuchal translucency (HP:0010880)2.12887334
100Absent radius (HP:0003974)2.12526841
101Supernumerary spleens (HP:0009799)2.11540375
102Short humerus (HP:0005792)2.11376654
103Hypoglycemic coma (HP:0001325)2.10858834
104Abnormality of the ischium (HP:0003174)2.10666483
105Biliary tract neoplasm (HP:0100574)2.10130210
106Soft skin (HP:0000977)2.09877711
107Short middle phalanx of the 5th finger (HP:0004220)2.09180829
108Hypoglycemic seizures (HP:0002173)2.09141869
109Limb-girdle muscle weakness (HP:0003325)2.08657704
110Aplasia/hypoplasia of the humerus (HP:0006507)2.08468849
111Bundle branch block (HP:0011710)2.08095839
112Hypoplastic pelvis (HP:0008839)2.07562806
113Fragile skin (HP:0001030)2.05236382
114Distal upper limb amyotrophy (HP:0007149)2.04630346
115Upper limb amyotrophy (HP:0009129)2.04630346
116Genu recurvatum (HP:0002816)2.04450794
117Mitral valve prolapse (HP:0001634)2.04007602
118Wormian bones (HP:0002645)2.03977740
119Gonadotropin excess (HP:0000837)2.03613603
120Muscular dystrophy (HP:0003560)2.01468595
121Palpitations (HP:0001962)2.00977902
122Medulloblastoma (HP:0002885)1.99648159
123Ovarian neoplasm (HP:0100615)1.99239782
124Absent phalangeal crease (HP:0006109)1.98484353
125Hyperinsulinemic hypoglycemia (HP:0000825)1.98412951
126Methylmalonic acidemia (HP:0002912)1.98002434
127Myelomeningocele (HP:0002475)1.96642273
128Pelvic girdle muscle weakness (HP:0003749)1.96032180
129Achilles tendon contracture (HP:0001771)1.96017037
130Aplasia involving forearm bones (HP:0009822)1.95124656
131Absent forearm bone (HP:0003953)1.95124656
132Abnormality of the preputium (HP:0100587)1.93297299
133Rectovaginal fistula (HP:0000143)1.92667093
134Rectal fistula (HP:0100590)1.92667093
135Neck muscle weakness (HP:0000467)1.92666844
136Ependymoma (HP:0002888)1.92455281
137Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.91945884
138Blue sclerae (HP:0000592)1.91748834
139Ventricular arrhythmia (HP:0004308)1.89391137
140Deformed tarsal bones (HP:0008119)1.88551697
141Abnormal umbilical cord blood vessels (HP:0011403)1.88321514
142Single umbilical artery (HP:0001195)1.88321514
143Abnormality of the fetal cardiovascular system (HP:0010948)1.88321514
144Absent septum pellucidum (HP:0001331)1.88308517
145Areflexia of lower limbs (HP:0002522)1.86631682
146Abnormality of the hip-girdle musculature (HP:0001445)1.86524297
147Abnormality of the musculature of the pelvis (HP:0001469)1.86524297
148Osteolytic defects of the phalanges of the hand (HP:0009771)1.86245556
149Osteolytic defects of the hand bones (HP:0009699)1.86245556
150Abnormality of the septum pellucidum (HP:0007375)1.86137964
151Anal stenosis (HP:0002025)1.86071432
152Volvulus (HP:0002580)1.85987792
153Radial bowing (HP:0002986)1.85640314
154Rectal prolapse (HP:0002035)1.84822169
155Facial diplegia (HP:0001349)1.83514706
156Irregular epiphyses (HP:0010582)1.83438678
157Bladder diverticulum (HP:0000015)1.82034904
158Generalized muscle weakness (HP:0003324)1.81577238
159Malignant gastrointestinal tract tumors (HP:0006749)1.81272527
160Gastrointestinal carcinoma (HP:0002672)1.81272527
161Lymphangioma (HP:0100764)1.80846431
162Abnormality of the shoulder girdle musculature (HP:0001435)1.80077584
163Embryonal neoplasm (HP:0002898)1.79192996
164Vertebral compression fractures (HP:0002953)1.78789148
165Abnormal atrioventricular conduction (HP:0005150)1.78158286
166Abnormality of sulfur amino acid metabolism (HP:0004339)1.77579237
167Neoplasm of the small intestine (HP:0100833)1.77349381
168Lower limb amyotrophy (HP:0007210)1.76160320
169Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.76067855
170Sloping forehead (HP:0000340)1.75892043
171Multiple enchondromatosis (HP:0005701)1.75695168
172Rimmed vacuoles (HP:0003805)1.75695015
173Myelodysplasia (HP:0002863)1.75127598
174Uterine neoplasm (HP:0010784)1.75074078
175Acanthocytosis (HP:0001927)1.74994134
176Abnormality of abdominal situs (HP:0011620)1.74723945
177Abdominal situs inversus (HP:0003363)1.74723945
178Abnormality of the pancreatic islet cells (HP:0006476)1.73140869
179Abnormality of endocrine pancreas physiology (HP:0012093)1.73140869
180Absent eyebrow (HP:0002223)1.73124020
181Anophthalmia (HP:0000528)1.72714761
182Broad foot (HP:0001769)1.71686322
183Proximal tubulopathy (HP:0000114)1.71070397
184Subacute progressive viral hepatitis (HP:0006572)1.70761392
185Abnormality of the Achilles tendon (HP:0005109)1.70274193
186Homocystinuria (HP:0002156)1.70067584
187Abnormality of homocysteine metabolism (HP:0010919)1.70067584
188Vaginal atresia (HP:0000148)1.68232389
189Vaginal fistula (HP:0004320)1.68202784
190Horseshoe kidney (HP:0000085)1.67889275
191Maternal diabetes (HP:0009800)1.65834211
192Genital tract atresia (HP:0001827)1.65305386
193Carpal bone hypoplasia (HP:0001498)1.63335357
194Preaxial foot polydactyly (HP:0001841)1.62326764
195Microvesicular hepatic steatosis (HP:0001414)1.62177859
196Aplasia/Hypoplasia of the sternum (HP:0006714)1.61621254
197Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.61231930
198Neoplasm of the adrenal gland (HP:0100631)1.60144539
199Increased hepatocellular lipid droplets (HP:0006565)1.60022082

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.65690296
2TRIB33.56100281
3BUB13.50626639
4PKN23.45448368
5TTK3.20345826
6CDC72.97943258
7MKNK12.89437632
8NEK12.78670523
9TRIM282.75673100
10WEE12.60436111
11SRPK12.58522437
12PBK2.56639472
13MKNK22.42581292
14PLK32.40671636
15PLK42.37917687
16EIF2AK32.36520258
17PDK42.35828866
18PDK32.35828866
19OBSCN2.34163734
20BRSK22.24346033
21TNIK2.15160597
22EPHA22.14422765
23TSSK62.14004066
24BCR2.09846664
25PHKG11.94285041
26PHKG21.94285041
27DDR21.94151057
28LATS11.93137293
29DMPK1.92681960
30PIK3CA1.91949555
31PDGFRA1.90373796
32EIF2AK11.87248119
33SCYL21.86982980
34MST41.85274899
35WNK31.80768940
36TESK11.77712621
37EEF2K1.73383478
38LIMK11.67826392
39PAK31.67789279
40NEK91.66009681
41LRRK21.65487674
42NUAK11.64440213
43RIPK11.62602073
44TAF11.59944959
45PASK1.58028907
46PLK11.51379668
47VRK21.50213578
48ACVR1B1.49513589
49LMTK21.47639407
50LATS21.45065963
51TRPM71.44766487
52PDK21.43070775
53VRK11.41104256
54PIM21.40178594
55MAPKAPK31.32845398
56PAK21.31875833
57FLT31.30370254
58FRK1.28926710
59BMPR1B1.28721060
60PIK3CG1.25973671
61NME21.22104688
62PTK61.21855693
63DYRK31.17012120
64CDK61.14977082
65CHEK21.14579011
66CDK191.14112745
67STK101.12070409
68MAP2K31.12029157
69BRD41.10684436
70FER1.09877822
71MYLK1.09538383
72STK161.08914341
73DYRK1B1.06836601
74RPS6KB21.06504655
75ILK1.06030126
76ATR1.03702802
77PAK41.03254510
78EIF2AK21.01119298
79CDK121.00638185
80PTK20.98574880
81MAP3K30.97762743
82STK38L0.96895064
83MAP3K50.95782126
84ZAK0.93902590
85PLK20.92038868
86DAPK30.90877439
87FGFR10.90110261
88CSNK1G10.89934373
89SIK10.87780759
90STK30.87758362
91RPS6KA40.86780012
92MTOR0.86436618
93BMX0.86224699
94BRSK10.85219826
95ROCK10.83814714
96TIE10.81512483
97TGFBR10.79945319
98ATM0.79608003
99ERN10.77545238
100MAP3K100.73248060
101MAP3K70.71600794
102PNCK0.71437512
103MET0.71264845
104ERBB30.70572403
105MAP3K80.69353957
106CHEK10.69187679
107MOS0.68876925
108MAP3K40.67074685
109CDK70.66765082
110STK240.66493456
111NLK0.65571525
112CSNK1G30.62764368
113BCKDK0.62377550
114PRKD10.61040427
115STK40.60350882
116TGFBR20.57789667
117MAP4K20.57525043
118CSNK1G20.57262883
119FGFR20.56559903
120TESK20.56256151
121DYRK20.55871554
122PDGFRB0.54615371
123FGFR30.54175312
124BRAF0.52584331
125MAP2K10.52040666
126ROCK20.51326476
127RET0.48721225
128EPHB20.47537531
129JAK10.46993463
130CSNK1A1L0.45768070
131ERBB40.45247235
132CDK10.44291532
133SIK30.43517703
134ALK0.42960011
135CSNK2A10.42350314
136PIM10.40840843
137CDK20.40439333
138FGFR40.40344720
139JAK30.38282858
140CSNK2A20.37649316
141CAMK1D0.36178225
142GRK10.35323764
143CSNK1E0.35100934
144CLK10.34642729
145PRKAA10.32849377
146PRKDC0.32811897
147YES10.32788720
148KSR10.32712101
149EPHA30.32235876
150CCNB10.31274338
151CDK180.30087865
152NEK20.30065045
153CDK40.29615892
154AKT20.29604057
155AURKB0.29152109
156INSR0.28564968
157TAOK20.28382679
158KDR0.27185417
159PRKAA20.27123260
160PRKG20.26926072
161EPHB10.26249624
162CDK90.25730931
163MAP2K70.25548371
164CHUK0.25470773
165CDK140.25018605
166MAPKAPK20.24997881
167MELK0.24666480
168EGFR0.24561027

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.31239472
2Mismatch repair_Homo sapiens_hsa034303.45630164
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.26142765
4Non-homologous end-joining_Homo sapiens_hsa034503.15941515
5Dilated cardiomyopathy_Homo sapiens_hsa054143.02405218
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.97275497
7DNA replication_Homo sapiens_hsa030302.94952706
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.86059017
9Viral myocarditis_Homo sapiens_hsa054162.44277236
10Focal adhesion_Homo sapiens_hsa045102.35540251
11Homologous recombination_Homo sapiens_hsa034402.26164043
12Steroid biosynthesis_Homo sapiens_hsa001002.17971398
13ECM-receptor interaction_Homo sapiens_hsa045122.17581622
14Proteasome_Homo sapiens_hsa030502.10736473
15Protein export_Homo sapiens_hsa030602.10734910
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.05085650
17Nucleotide excision repair_Homo sapiens_hsa034202.04516531
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.00774825
19Adherens junction_Homo sapiens_hsa045202.00719468
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.99756427
21Fanconi anemia pathway_Homo sapiens_hsa034601.98494483
22Spliceosome_Homo sapiens_hsa030401.96068989
23* p53 signaling pathway_Homo sapiens_hsa041151.93909552
24Small cell lung cancer_Homo sapiens_hsa052221.93342605
25Proteoglycans in cancer_Homo sapiens_hsa052051.93191506
26Carbon metabolism_Homo sapiens_hsa012001.90033640
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.85915298
28Base excision repair_Homo sapiens_hsa034101.85281918
29Ribosome_Homo sapiens_hsa030101.75609189
30Bladder cancer_Homo sapiens_hsa052191.73389221
31Basal transcription factors_Homo sapiens_hsa030221.66896070
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.66363304
33RNA degradation_Homo sapiens_hsa030181.64174121
34Fatty acid degradation_Homo sapiens_hsa000711.59390518
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59052627
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.56292287
37mRNA surveillance pathway_Homo sapiens_hsa030151.50050602
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49108686
39Fatty acid elongation_Homo sapiens_hsa000621.45444795
40Cardiac muscle contraction_Homo sapiens_hsa042601.45124465
41Tight junction_Homo sapiens_hsa045301.42344816
42Chronic myeloid leukemia_Homo sapiens_hsa052201.42299679
43Selenocompound metabolism_Homo sapiens_hsa004501.41648975
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.40200966
45Propanoate metabolism_Homo sapiens_hsa006401.38062466
46HIF-1 signaling pathway_Homo sapiens_hsa040661.36023397
47Amoebiasis_Homo sapiens_hsa051461.35417342
48* MicroRNAs in cancer_Homo sapiens_hsa052061.35237471
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.31432735
50RNA polymerase_Homo sapiens_hsa030201.30723858
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.29857953
52mTOR signaling pathway_Homo sapiens_hsa041501.29087785
53Hippo signaling pathway_Homo sapiens_hsa043901.28808191
54Regulation of actin cytoskeleton_Homo sapiens_hsa048101.26877292
55Central carbon metabolism in cancer_Homo sapiens_hsa052301.20635200
56Insulin resistance_Homo sapiens_hsa049311.20108817
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.16332633
58Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16047153
59AMPK signaling pathway_Homo sapiens_hsa041521.11546286
60Insulin signaling pathway_Homo sapiens_hsa049101.11186014
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.10085381
62Fatty acid metabolism_Homo sapiens_hsa012121.07350364
63Biosynthesis of amino acids_Homo sapiens_hsa012301.07109776
64Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05372681
65Melanoma_Homo sapiens_hsa052181.03598349
66TGF-beta signaling pathway_Homo sapiens_hsa043501.03553471
67Adipocytokine signaling pathway_Homo sapiens_hsa049201.00428703
68Oocyte meiosis_Homo sapiens_hsa041140.99794760
69Viral carcinogenesis_Homo sapiens_hsa052030.98620360
70Glutathione metabolism_Homo sapiens_hsa004800.98374458
71Pyrimidine metabolism_Homo sapiens_hsa002400.97649456
72Toxoplasmosis_Homo sapiens_hsa051450.95008275
73Vitamin B6 metabolism_Homo sapiens_hsa007500.94251100
74PI3K-Akt signaling pathway_Homo sapiens_hsa041510.92994982
75Shigellosis_Homo sapiens_hsa051310.92374870
76Purine metabolism_Homo sapiens_hsa002300.92095064
77Pyruvate metabolism_Homo sapiens_hsa006200.88572934
78Glucagon signaling pathway_Homo sapiens_hsa049220.86022285
79FoxO signaling pathway_Homo sapiens_hsa040680.84504410
80Pancreatic cancer_Homo sapiens_hsa052120.82974763
81HTLV-I infection_Homo sapiens_hsa051660.82671247
82Renal cell carcinoma_Homo sapiens_hsa052110.81944239
83Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.81907273
84Apoptosis_Homo sapiens_hsa042100.81752528
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.80597568
86Parkinsons disease_Homo sapiens_hsa050120.80521651
87Glioma_Homo sapiens_hsa052140.79614676
88Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79300756
89Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79113497
90Wnt signaling pathway_Homo sapiens_hsa043100.78515527
91Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78115903
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78078165
93Legionellosis_Homo sapiens_hsa051340.76326730
94Hedgehog signaling pathway_Homo sapiens_hsa043400.76286196
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75831079
96Arginine and proline metabolism_Homo sapiens_hsa003300.75510580
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74478428
98Fat digestion and absorption_Homo sapiens_hsa049750.74120636
99Thyroid cancer_Homo sapiens_hsa052160.73583338
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73403413
101Platelet activation_Homo sapiens_hsa046110.73354342
102Endometrial cancer_Homo sapiens_hsa052130.71821625
103Starch and sucrose metabolism_Homo sapiens_hsa005000.69461182
104Pathways in cancer_Homo sapiens_hsa052000.69234935
105Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.67005666
106Huntingtons disease_Homo sapiens_hsa050160.66831592
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66820327
108Protein digestion and absorption_Homo sapiens_hsa049740.65553999
109Butanoate metabolism_Homo sapiens_hsa006500.64042546
110Colorectal cancer_Homo sapiens_hsa052100.64001730
111VEGF signaling pathway_Homo sapiens_hsa043700.63372771
112Prostate cancer_Homo sapiens_hsa052150.62666034
113N-Glycan biosynthesis_Homo sapiens_hsa005100.61664852
114Malaria_Homo sapiens_hsa051440.58982793
115Vitamin digestion and absorption_Homo sapiens_hsa049770.58162683
116Oxidative phosphorylation_Homo sapiens_hsa001900.57762941
117Salmonella infection_Homo sapiens_hsa051320.57189183
118Metabolic pathways_Homo sapiens_hsa011000.57003158
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.55796796
120Alcoholism_Homo sapiens_hsa050340.54624545
121Peroxisome_Homo sapiens_hsa041460.54472003
122Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.54136251
123Hepatitis B_Homo sapiens_hsa051610.53609438
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52498363
125RNA transport_Homo sapiens_hsa030130.52262793
126TNF signaling pathway_Homo sapiens_hsa046680.51710142
127Lysine degradation_Homo sapiens_hsa003100.49738060
128Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49676255
129Systemic lupus erythematosus_Homo sapiens_hsa053220.48590915
130Rap1 signaling pathway_Homo sapiens_hsa040150.48190261
131Non-small cell lung cancer_Homo sapiens_hsa052230.48041822
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47357412
133Cell cycle_Homo sapiens_hsa041100.47156850
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47003765
135cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46005454
136Galactose metabolism_Homo sapiens_hsa000520.45640397
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45055365
138Arginine biosynthesis_Homo sapiens_hsa002200.44334251
139Basal cell carcinoma_Homo sapiens_hsa052170.44312090
140Leishmaniasis_Homo sapiens_hsa051400.43665098
141Renin-angiotensin system_Homo sapiens_hsa046140.42396764
142Acute myeloid leukemia_Homo sapiens_hsa052210.41243236
143Endocytosis_Homo sapiens_hsa041440.40628081
144Sulfur metabolism_Homo sapiens_hsa009200.40332550
145Oxytocin signaling pathway_Homo sapiens_hsa049210.39405331
146Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.38718669
147Folate biosynthesis_Homo sapiens_hsa007900.38292683
148PPAR signaling pathway_Homo sapiens_hsa033200.38170056
149One carbon pool by folate_Homo sapiens_hsa006700.36863729
150beta-Alanine metabolism_Homo sapiens_hsa004100.35640961
151Jak-STAT signaling pathway_Homo sapiens_hsa046300.35287737
152Pentose phosphate pathway_Homo sapiens_hsa000300.32563301
153Prolactin signaling pathway_Homo sapiens_hsa049170.31824992
154Retinol metabolism_Homo sapiens_hsa008300.30588746
155Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.30389556
156Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29273706
157Antigen processing and presentation_Homo sapiens_hsa046120.29030473
158Nitrogen metabolism_Homo sapiens_hsa009100.21548399
159Primary bile acid biosynthesis_Homo sapiens_hsa001200.21416914
160Alzheimers disease_Homo sapiens_hsa050100.17637718
161Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16995995
162Tryptophan metabolism_Homo sapiens_hsa003800.15027682

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