CCNA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.63468727
2mitotic metaphase plate congression (GO:0007080)5.63277624
3regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.45464209
4mitotic sister chromatid segregation (GO:0000070)5.24706982
5protein localization to chromosome, centromeric region (GO:0071459)5.23757368
6mitotic chromosome condensation (GO:0007076)5.04986773
7sister chromatid segregation (GO:0000819)4.98113269
8DNA unwinding involved in DNA replication (GO:0006268)4.89397026
9metaphase plate congression (GO:0051310)4.87257256
10regulation of spindle organization (GO:0090224)4.84146492
11kinetochore organization (GO:0051383)4.73172668
12DNA replication initiation (GO:0006270)4.68986202
13DNA strand elongation involved in DNA replication (GO:0006271)4.65056046
14CENP-A containing nucleosome assembly (GO:0034080)4.57134398
15attachment of spindle microtubules to kinetochore (GO:0008608)4.56063772
16mitotic nuclear envelope disassembly (GO:0007077)4.51179762
17establishment of integrated proviral latency (GO:0075713)4.49116216
18chromatin remodeling at centromere (GO:0031055)4.48786122
19DNA replication checkpoint (GO:0000076)4.47468509
20DNA ligation (GO:0006266)4.43218771
21DNA strand elongation (GO:0022616)4.42083579
22establishment of chromosome localization (GO:0051303)4.39548919
23regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.34743873
24positive regulation of chromosome segregation (GO:0051984)4.33294133
25nuclear pore organization (GO:0006999)4.27680668
26telomere maintenance via semi-conservative replication (GO:0032201)4.27193103
27DNA replication-independent nucleosome organization (GO:0034724)4.25450555
28DNA replication-independent nucleosome assembly (GO:0006336)4.25450555
29nuclear envelope disassembly (GO:0051081)4.20882663
30membrane disassembly (GO:0030397)4.20882663
31kinetochore assembly (GO:0051382)4.17884372
32DNA replication-dependent nucleosome organization (GO:0034723)4.17240044
33DNA replication-dependent nucleosome assembly (GO:0006335)4.17240044
34regulation of chromosome segregation (GO:0051983)4.14916803
35spindle checkpoint (GO:0031577)4.12535348
36regulation of mitotic spindle organization (GO:0060236)4.06136599
37protein localization to chromosome (GO:0034502)4.00978496
38nuclear pore complex assembly (GO:0051292)4.00523626
39mitotic recombination (GO:0006312)3.98560307
40telomere maintenance via recombination (GO:0000722)3.93157185
41spindle assembly checkpoint (GO:0071173)3.92677447
42negative regulation of chromosome segregation (GO:0051985)3.92198508
43histone exchange (GO:0043486)3.90886566
44negative regulation of mitotic sister chromatid separation (GO:2000816)3.87716321
45negative regulation of mitotic sister chromatid segregation (GO:0033048)3.87716321
46negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.87716321
47negative regulation of sister chromatid segregation (GO:0033046)3.87716321
48positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.87166599
49positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.87166599
50positive regulation of mitotic sister chromatid separation (GO:1901970)3.87166599
51mitotic spindle assembly checkpoint (GO:0007094)3.85312398
52mitotic sister chromatid cohesion (GO:0007064)3.85068179
53mitotic spindle checkpoint (GO:0071174)3.84235982
54regulation of mitotic metaphase/anaphase transition (GO:0030071)3.83352668
55meiotic chromosome segregation (GO:0045132)3.81572512
56nucleobase biosynthetic process (GO:0046112)3.79020971
57negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.77866913
58regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.75840935
59chromosome segregation (GO:0007059)3.71557595
60regulation of sister chromatid cohesion (GO:0007063)3.71162484
61purine nucleobase biosynthetic process (GO:0009113)3.70399882
62regulation of sister chromatid segregation (GO:0033045)3.64337873
63regulation of mitotic sister chromatid separation (GO:0010965)3.64337873
64regulation of mitotic sister chromatid segregation (GO:0033047)3.64337873
65chromatin assembly or disassembly (GO:0006333)3.59676288
66regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.57577576
67folic acid-containing compound biosynthetic process (GO:0009396)3.54419258
68regulation of centrosome cycle (GO:0046605)3.52252495
69telomere maintenance via telomere lengthening (GO:0010833)3.51954136
70protein K6-linked ubiquitination (GO:0085020)3.40654316
71nucleotide-excision repair, DNA gap filling (GO:0006297)3.39213681
72chromosome condensation (GO:0030261)3.38772171
73protein complex localization (GO:0031503)3.38767360
74establishment of viral latency (GO:0019043)3.38650861
75nuclear envelope organization (GO:0006998)3.37420748
76ribosome assembly (GO:0042255)3.31712410
77ATP-dependent chromatin remodeling (GO:0043044)3.27657578
78regulation of exit from mitosis (GO:0007096)3.26652386
79heterochromatin organization (GO:0070828)3.26652350
80DNA geometric change (GO:0032392)3.23310918
81regulation of translational fidelity (GO:0006450)3.23144668
82DNA duplex unwinding (GO:0032508)3.23116896
83histone-serine phosphorylation (GO:0035404)3.23049795
84IMP biosynthetic process (GO:0006188)3.22334893
85formation of translation preinitiation complex (GO:0001731)3.19357990
86double-strand break repair via nonhomologous end joining (GO:0006303)3.17898280
87non-recombinational repair (GO:0000726)3.17898280
88microtubule depolymerization (GO:0007019)3.16151587
89DNA topological change (GO:0006265)3.12762886
90* mitotic cell cycle (GO:0000278)3.12127934
91maturation of SSU-rRNA (GO:0030490)3.10387123
92translesion synthesis (GO:0019985)3.08628529
93regulation of double-strand break repair via homologous recombination (GO:0010569)3.08520318
94pore complex assembly (GO:0046931)3.06059835
95cellular protein complex localization (GO:0034629)3.04448266
96negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)3.01621704
97negative regulation of mitosis (GO:0045839)3.00346068
98DNA conformation change (GO:0071103)2.99343949
99negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.98928945
100DNA packaging (GO:0006323)2.97247540
101mitotic spindle organization (GO:0007052)2.96590495
102ribosome biogenesis (GO:0042254)2.96557216
103spindle assembly involved in mitosis (GO:0090307)2.95610981
104chromosome organization (GO:0051276)2.95530683
105regulation of spindle checkpoint (GO:0090231)2.92931939
106spindle organization (GO:0007051)2.91506111
107maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.91133359
108regulation of telomere maintenance via telomerase (GO:0032210)2.90509491
109spliceosomal snRNP assembly (GO:0000387)2.89803031
110postreplication repair (GO:0006301)2.88871657
111anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.88155026
112regulation of histone H3-K9 methylation (GO:0051570)2.87057514
113regulation of centriole replication (GO:0046599)2.86893596
114IMP metabolic process (GO:0046040)2.83228900
115negative regulation of RNA splicing (GO:0033119)2.81439635

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.92325286
2* FOXM1_23109430_ChIP-Seq_U2OS_Human6.62106665
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.52144886
4* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.10675170
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.90548468
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.40448007
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.79270169
8* AR_21909140_ChIP-Seq_LNCAP_Human2.74514030
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.73114482
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.67547466
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62885674
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.46058969
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.38744809
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.37133322
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.33672753
16* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.32797088
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.32098778
18NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31933646
19XRN2_22483619_ChIP-Seq_HELA_Human2.21597107
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.18545704
21* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.08514939
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.08428568
23MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07898955
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99361838
25* VDR_23849224_ChIP-Seq_CD4+_Human1.92058932
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.90023469
27* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89602967
28NANOG_18555785_ChIP-Seq_MESCs_Mouse1.76691251
29FOXP3_21729870_ChIP-Seq_TREG_Human1.73529348
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73317448
31DCP1A_22483619_ChIP-Seq_HELA_Human1.73218057
32MYC_22102868_ChIP-Seq_BL_Human1.71802734
33GABP_19822575_ChIP-Seq_HepG2_Human1.64908283
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64795029
35* TTF2_22483619_ChIP-Seq_HELA_Human1.60601138
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.58033301
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.57623609
38CIITA_25753668_ChIP-Seq_RAJI_Human1.55348731
39KDM5A_27292631_Chip-Seq_BREAST_Human1.52457999
40* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51451163
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48448778
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46111706
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.45364133
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44289840
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.44121209
46ELK1_19687146_ChIP-ChIP_HELA_Human1.42806157
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.36603173
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33533944
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32769198
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32754407
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.32471041
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32099286
53E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.29893791
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29603958
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.28061278
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27677434
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25267139
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.25196344
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22764296
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21658221
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17765360
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17263376
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.16609183
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.15821710
65CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11270461
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10536397
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10259399
68* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10058174
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10025206
70POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09118939
71CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.07857639
72YY1_21170310_ChIP-Seq_MESCs_Mouse1.06547605
73* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05602167
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.05135470
75ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04766414
76PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.04040548
77VDR_21846776_ChIP-Seq_THP-1_Human1.03596359
78TFEB_21752829_ChIP-Seq_HELA_Human1.03341470
79* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03269733
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00640209
81NANOG_21062744_ChIP-ChIP_HESCs_Human0.99705926
82* SOX17_20123909_ChIP-Seq_XEN_Mouse0.98291024
83SOX2_16153702_ChIP-ChIP_HESCs_Human0.96567425
84KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.94603141
85TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92099882
86* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90671570
87MYC_18940864_ChIP-ChIP_HL60_Human0.89818699
88* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.89508475
89* SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86932709
90HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86777138
91ZNF263_19887448_ChIP-Seq_K562_Human0.85207734
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81535687
93* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.81385693
94SRF_21415370_ChIP-Seq_HL-1_Mouse0.80943243
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.80938879
96ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.79254801
97FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.79176236
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79031340
99PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.77660802
100TCF3_18692474_ChIP-Seq_MEFs_Mouse0.77566504
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.76869682
102* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.76495362
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76412338
104ESR1_15608294_ChIP-ChIP_MCF-7_Human0.75191820
105CHD1_26751641_Chip-Seq_LNCaP_Human0.73337526
106DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73295024
107SPI1_23547873_ChIP-Seq_NB4_Human0.71342360
108NANOG_16153702_ChIP-ChIP_HESCs_Human0.68818590
109TBX5_21415370_ChIP-Seq_HL-1_Mouse0.67730804

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.80879530
2MP0003111_abnormal_nucleus_morphology5.03766990
3MP0010094_abnormal_chromosome_stability4.95687917
4MP0004957_abnormal_blastocyst_morpholog4.38265766
5* MP0003077_abnormal_cell_cycle4.20029755
6MP0008057_abnormal_DNA_replication3.68566467
7MP0008007_abnormal_cellular_replicative2.85730103
8MP0008058_abnormal_DNA_repair2.81648705
9MP0008932_abnormal_embryonic_tissue2.69468003
10MP0003123_paternal_imprinting2.68893247
11MP0001730_embryonic_growth_arrest2.55501026
12MP0010307_abnormal_tumor_latency2.51245528
13MP0000350_abnormal_cell_proliferation2.40072555
14MP0009697_abnormal_copulation2.11316011
15MP0002396_abnormal_hematopoietic_system2.04605857
16MP0008877_abnormal_DNA_methylation2.01592849
17MP0010352_gastrointestinal_tract_polyps1.92379943
18MP0001697_abnormal_embryo_size1.89012793
19* MP0001672_abnormal_embryogenesis/_devel1.88234261
20* MP0005380_embryogenesis_phenotype1.88234261
21MP0002085_abnormal_embryonic_tissue1.72511800
22MP0003984_embryonic_growth_retardation1.71974945
23MP0005076_abnormal_cell_differentiation1.71662406
24MP0003786_premature_aging1.70611119
25* MP0002080_prenatal_lethality1.68497546
26MP0002088_abnormal_embryonic_growth/wei1.68243540
27MP0003718_maternal_effect1.67886736
28MP0000490_abnormal_crypts_of1.66613256
29MP0002084_abnormal_developmental_patter1.59151594
30MP0002086_abnormal_extraembryonic_tissu1.54156864
31MP0004808_abnormal_hematopoietic_stem1.53282020
32MP0003121_genomic_imprinting1.51962616
33MP0003567_abnormal_fetal_cardiomyocyte1.49474184
34MP0004197_abnormal_fetal_growth/weight/1.47121247
35MP0010030_abnormal_orbit_morphology1.41887022
36MP0000313_abnormal_cell_death1.40781586
37MP0002019_abnormal_tumor_incidence1.39783521
38MP0000537_abnormal_urethra_morphology1.21820668
39MP0009333_abnormal_splenocyte_physiolog1.20944125
40MP0003315_abnormal_perineum_morphology1.19163984
41MP0003705_abnormal_hypodermis_morpholog1.17863566
42MP0001545_abnormal_hematopoietic_system1.17678982
43MP0005397_hematopoietic_system_phenotyp1.17678982
44MP0002210_abnormal_sex_determination1.17014362
45MP0009053_abnormal_anal_canal1.16702169
46MP0003937_abnormal_limbs/digits/tail_de1.16205016
47MP0001293_anophthalmia1.15901965
48MP0002009_preneoplasia1.10093899
49MP0006054_spinal_hemorrhage1.05442434
50MP0004233_abnormal_muscle_weight1.04862792
51MP0004185_abnormal_adipocyte_glucose1.04445862
52MP0001145_abnormal_male_reproductive1.04330810
53MP0009672_abnormal_birth_weight1.02473082
54MP0010234_abnormal_vibrissa_follicle1.01901371
55MP0000703_abnormal_thymus_morphology1.01474251
56MP0002102_abnormal_ear_morphology0.99778360
57MP0003890_abnormal_embryonic-extraembry0.99433473
58MP0001346_abnormal_lacrimal_gland0.99177932
59MP0006035_abnormal_mitochondrial_morpho0.96463491
60MP0003221_abnormal_cardiomyocyte_apopto0.95712869
61MP0003656_abnormal_erythrocyte_physiolo0.94583930
62MP0005501_abnormal_skin_physiology0.94524299
63MP0001929_abnormal_gametogenesis0.93340359
64MP0000653_abnormal_sex_gland0.91604806
65MP0009278_abnormal_bone_marrow0.90588532
66MP0000428_abnormal_craniofacial_morphol0.87903779
67MP0003385_abnormal_body_wall0.86369614
68MP0002398_abnormal_bone_marrow0.86216623
69MP0002722_abnormal_immune_system0.84230501
70MP0003119_abnormal_digestive_system0.84206662
71MP0005621_abnormal_cell_physiology0.82978859
72MP0009703_decreased_birth_body0.81745877
73MP0000733_abnormal_muscle_development0.80681290
74MP0002092_abnormal_eye_morphology0.80253799
75MP0005384_cellular_phenotype0.79148403
76MP0002111_abnormal_tail_morphology0.78985386
77MP0002233_abnormal_nose_morphology0.78975568
78MP0001529_abnormal_vocalization0.78829862
79MP0001119_abnormal_female_reproductive0.78678120
80MP0002653_abnormal_ependyma_morphology0.78297084
81MP0001661_extended_life_span0.77586969
82MP0000689_abnormal_spleen_morphology0.75536001
83MP0001727_abnormal_embryo_implantation0.74515673
84MP0002877_abnormal_melanocyte_morpholog0.72951387
85MP0005623_abnormal_meninges_morphology0.72404397
86MP0001849_ear_inflammation0.72179625
87MP0001915_intracranial_hemorrhage0.71950389
88MP0002234_abnormal_pharynx_morphology0.71672032
89MP0003806_abnormal_nucleotide_metabolis0.70473990
90MP0002796_impaired_skin_barrier0.69554874
91MP0002160_abnormal_reproductive_system0.69497643
92MP0000566_synostosis0.69295603
93MP0003935_abnormal_craniofacial_develop0.68403123
94MP0003115_abnormal_respiratory_system0.68300611
95MP0001286_abnormal_eye_development0.67243711
96MP0008789_abnormal_olfactory_epithelium0.67194312
97MP0000383_abnormal_hair_follicle0.67083034
98MP0005023_abnormal_wound_healing0.66024183
99MP0004264_abnormal_extraembryonic_tissu0.65663597
100MP0005389_reproductive_system_phenotype0.65442043
101MP0002161_abnormal_fertility/fecundity0.65198713
102MP0000358_abnormal_cell_content/0.64717664
103MP0000432_abnormal_head_morphology0.64317466
104MP0003763_abnormal_thymus_physiology0.63975290
105MP0000858_altered_metastatic_potential0.63888265
106MP0003941_abnormal_skin_development0.62748341
107MP0002429_abnormal_blood_cell0.62634889
108MP0004147_increased_porphyrin_level0.62613272
109MP0000049_abnormal_middle_ear0.62432475
110MP0003566_abnormal_cell_adhesion0.61848637
111MP0003942_abnormal_urinary_system0.61594164
112MP0000477_abnormal_intestine_morphology0.60846038
113MP0006292_abnormal_olfactory_placode0.60657732
114MP0005395_other_phenotype0.60161459
115MP0001881_abnormal_mammary_gland0.59429439
116MP0000762_abnormal_tongue_morphology0.59160934
117MP0003699_abnormal_female_reproductive0.58752068
118MP0001299_abnormal_eye_distance/0.58294134
119MP0002925_abnormal_cardiovascular_devel0.56782822
120MP0002697_abnormal_eye_size0.55788235
121MP0003186_abnormal_redox_activity0.55700384
122MP0002932_abnormal_joint_morphology0.55645382
123MP0003950_abnormal_plasma_membrane0.55275126
124MP0002114_abnormal_axial_skeleton0.55104254
125MP0003861_abnormal_nervous_system0.54264431
126MP0003938_abnormal_ear_development0.53514862
127MP0008770_decreased_survivor_rate0.53432436
128MP0002938_white_spotting0.52997909
129MP0003755_abnormal_palate_morphology0.51995102

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.88521780
2Chromsome breakage (HP:0040012)4.16273958
3Chromosomal breakage induced by crosslinking agents (HP:0003221)4.00139117
4Breast hypoplasia (HP:0003187)3.99937758
5Cortical dysplasia (HP:0002539)3.72747487
6Patellar aplasia (HP:0006443)3.72169196
7Abnormality of chromosome stability (HP:0003220)3.57120101
8Aplasia/Hypoplasia of the patella (HP:0006498)3.54058122
9Reticulocytopenia (HP:0001896)3.31646359
10Meckel diverticulum (HP:0002245)3.26703904
11Impulsivity (HP:0100710)3.25915331
12Abnormality of the preputium (HP:0100587)3.13496690
13Oral leukoplakia (HP:0002745)3.13206319
14Selective tooth agenesis (HP:0001592)3.12645243
15Medulloblastoma (HP:0002885)3.08692583
16Abnormality of the ileum (HP:0001549)3.07166917
17Small intestinal stenosis (HP:0012848)3.05786965
18Duodenal stenosis (HP:0100867)3.05786965
19Aplasia/Hypoplasia of the sacrum (HP:0008517)3.05758481
20Aplasia/Hypoplasia of the uvula (HP:0010293)3.04855626
21Carpal bone hypoplasia (HP:0001498)2.96200543
22Increased nuchal translucency (HP:0010880)2.94909165
23Ependymoma (HP:0002888)2.93780133
24Colon cancer (HP:0003003)2.87907933
25Facial hemangioma (HP:0000329)2.80252027
26Abnormality of the labia minora (HP:0012880)2.77627318
27Myelodysplasia (HP:0002863)2.75295687
28Absent radius (HP:0003974)2.71598896
29Abnormality of cells of the erythroid lineage (HP:0012130)2.71041747
30Volvulus (HP:0002580)2.69516204
31Proximal placement of thumb (HP:0009623)2.65756162
32Abnormal number of erythroid precursors (HP:0012131)2.62135113
33Rough bone trabeculation (HP:0100670)2.60176002
34Rhabdomyosarcoma (HP:0002859)2.60035256
35Ectopic kidney (HP:0000086)2.57177070
36Deviation of the thumb (HP:0009603)2.54229969
37Absent forearm bone (HP:0003953)2.52547679
38Aplasia involving forearm bones (HP:0009822)2.52547679
39Abnormality of the duodenum (HP:0002246)2.50791395
40Neoplasm of the pancreas (HP:0002894)2.49356810
41Atresia of the external auditory canal (HP:0000413)2.47238153
42Sloping forehead (HP:0000340)2.46144966
43Abnormal lung lobation (HP:0002101)2.43075963
44Short 4th metacarpal (HP:0010044)2.42595454
45Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.42595454
46Cafe-au-lait spot (HP:0000957)2.42436250
47Microvesicular hepatic steatosis (HP:0001414)2.41472786
48Absent thumb (HP:0009777)2.35278333
49Abnormality of the anterior horn cell (HP:0006802)2.34547725
50Degeneration of anterior horn cells (HP:0002398)2.34547725
51Prominent nose (HP:0000448)2.31525539
52Aplastic anemia (HP:0001915)2.30226157
53Abnormality of the carotid arteries (HP:0005344)2.27806085
54Bone marrow hypocellularity (HP:0005528)2.27535875
55Embryonal neoplasm (HP:0002898)2.27415109
56Abnormal number of incisors (HP:0011064)2.25500793
57High pitched voice (HP:0001620)2.25164704
58Abnormality of glycolysis (HP:0004366)2.24386913
59Basal cell carcinoma (HP:0002671)2.21281943
60Deep philtrum (HP:0002002)2.18347869
61Short middle phalanx of the 5th finger (HP:0004220)2.18175568
62Agnosia (HP:0010524)2.17982997
63Short thumb (HP:0009778)2.16893893
64Tracheoesophageal fistula (HP:0002575)2.16398317
65Missing ribs (HP:0000921)2.15884927
66Hypoplasia of the capital femoral epiphysis (HP:0003090)2.15361890
67Squamous cell carcinoma (HP:0002860)2.14851134
68Premature graying of hair (HP:0002216)2.14091463
69Horseshoe kidney (HP:0000085)2.13901233
70Microretrognathia (HP:0000308)2.12741163
71Increased serum pyruvate (HP:0003542)2.12290791
72Aplasia/Hypoplasia of the sternum (HP:0006714)2.11952428
73Duplication of thumb phalanx (HP:0009942)2.10454339
74Overlapping toe (HP:0001845)2.06133539
75Triphalangeal thumb (HP:0001199)2.04122150
76Slender long bone (HP:0003100)2.03607725
77Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.02950035
78High anterior hairline (HP:0009890)2.02328745
79Oligodactyly (HP:0012165)2.02108767
80Cleft eyelid (HP:0000625)2.01279893
81Nephroblastoma (Wilms tumor) (HP:0002667)2.00805905
82Progressive external ophthalmoplegia (HP:0000590)2.00625893
83Glioma (HP:0009733)2.00469786
84Neoplasm of striated muscle (HP:0009728)1.99481495
85Progressive muscle weakness (HP:0003323)1.97117294
86Macrocytic anemia (HP:0001972)1.96219165
87Arteriovenous malformation (HP:0100026)1.95385977
88Astrocytoma (HP:0009592)1.94996307
89Abnormality of the astrocytes (HP:0100707)1.94996307
90Abnormality of cochlea (HP:0000375)1.93540974
91Abnormality of the heme biosynthetic pathway (HP:0010472)1.93199614
92Supernumerary spleens (HP:0009799)1.92641816
93Pallor (HP:0000980)1.92492092
94Cellular immunodeficiency (HP:0005374)1.91451442
95Abnormality of chromosome segregation (HP:0002916)1.90386631
96Abnormal gallbladder physiology (HP:0012438)1.89410478
97Cholecystitis (HP:0001082)1.89410478
98Pelvic girdle muscle weakness (HP:0003749)1.89344149
99Ankle contracture (HP:0006466)1.88011576
100Hypoplastic pelvis (HP:0008839)1.87476553
101Abnormality of the fetal cardiovascular system (HP:0010948)1.85934257
102Abnormal umbilical cord blood vessels (HP:0011403)1.85934257
103Single umbilical artery (HP:0001195)1.85934257
104Secondary amenorrhea (HP:0000869)1.85876993
105Embryonal renal neoplasm (HP:0011794)1.85839979
106Abnormal trabecular bone morphology (HP:0100671)1.83645525
107Entropion (HP:0000621)1.83246516
108Abnormality of the umbilical cord (HP:0010881)1.82745773
109Abnormality of reticulocytes (HP:0004312)1.81952797
110Long eyelashes (HP:0000527)1.81702150
111Cerebral hypomyelination (HP:0006808)1.80989692
112Abnormality of the calcaneus (HP:0008364)1.80725545
113Choanal atresia (HP:0000453)1.79726781
11411 pairs of ribs (HP:0000878)1.78694727
115Clubbing of toes (HP:0100760)1.78092977
116Premature ovarian failure (HP:0008209)1.77903493
117Trismus (HP:0000211)1.76645592
118Neoplasm of the colon (HP:0100273)1.76327312
119Microtia (HP:0008551)1.76248022
120Aplasia/Hypoplasia of the earlobes (HP:0009906)1.75265102
121Multiple enchondromatosis (HP:0005701)1.74758697
122Insomnia (HP:0100785)1.74353906
123Duplicated collecting system (HP:0000081)1.73719534
124Broad distal phalanx of finger (HP:0009836)1.69238298
125Facial cleft (HP:0002006)1.68972536
126Orthostatic hypotension (HP:0001278)1.68062602
127Leiomyosarcoma (HP:0100243)1.64737062
128Uterine leiomyosarcoma (HP:0002891)1.64737062
129Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.63857155
130Absent epiphyses (HP:0010577)1.63857155
131Malignant gastrointestinal tract tumors (HP:0006749)1.62739534
132Gastrointestinal carcinoma (HP:0002672)1.62739534
133Poikiloderma (HP:0001029)1.62579413
134Microglossia (HP:0000171)1.61746090
135Abnormality of DNA repair (HP:0003254)1.61324796
136Small epiphyses (HP:0010585)1.61089528

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.46180190
2CDC74.50365187
3WEE14.34137448
4NEK23.89033276
5EIF2AK12.95473782
6TTK2.84213340
7BRSK22.37433931
8PLK42.32282815
9PLK12.26405952
10NEK12.24924625
11ACVR1B2.23067733
12BRSK12.09535115
13AURKB2.05461292
14SRPK12.05125287
15VRK21.77953342
16EEF2K1.76476523
17CDK41.69315624
18STK101.69270173
19MKNK11.68163091
20CHEK21.68033998
21DYRK31.68019390
22CDK121.67275263
23PLK31.65470887
24TLK11.59575736
25RPS6KA41.59378262
26MAP3K81.59275496
27ATR1.58431589
28CDK71.52622959
29TSSK61.52572973
30TESK21.51741552
31MKNK21.49526361
32SMG11.48734477
33STK41.47799718
34AURKA1.46814017
35NME21.46571459
36CCNB11.44020010
37VRK11.41116085
38TAF11.35297673
39MAP3K101.34342722
40RPS6KB21.32755786
41CHEK11.28675560
42MELK1.24206746
43STK31.19377128
44PASK1.17849938
45EIF2AK31.16288401
46SCYL21.12191824
47PKN21.09037141
48CDK61.04736579
49ZAK0.98008423
50PAK40.93816749
51ATM0.93018416
52MST40.91142614
53* CDK20.84458188
54LATS20.76175466
55STK160.75999282
56LATS10.73129885
57CDK10.72137997
58PAK10.70654465
59TGFBR10.70453586
60PIM10.67364154
61BRD40.66724240
62ICK0.66714050
63CDK80.65781969
64EPHA20.65156113
65PBK0.64796246
66ALK0.61418491
67BRAF0.61210378
68TRIM280.58810166
69NME10.57382805
70TRIB30.55951061
71FLT30.54946359
72LRRK20.52308251
73ERBB40.51735290
74CDK90.51431956
75EIF2AK20.51053316
76RPS6KA50.50208126
77CSNK2A10.48762564
78PNCK0.47853699
79CSNK2A20.45956778
80AKT20.43514877
81MTOR0.42836424
82MAPK110.42648468
83KSR20.41787211
84STK38L0.40148725
85MARK30.39734529
86NUAK10.37159151
87PRKCI0.36389883
88CLK10.35127184
89MET0.33621126
90MAPKAPK30.33458063
91MST1R0.33367268
92MAP4K10.33332191
93PRKDC0.32017952
94KDR0.30687033
95FGFR10.30646705
96MAP3K110.29153053
97NEK90.28770756
98RAF10.28708159
99DYRK20.27787383
100MAP3K90.26512455
101CSNK1E0.25978181
102MAP3K50.24675489
103MAPK140.24521149
104CDK11A0.24435414
105MAP2K30.24179611
106PAK20.24083974
107CDK150.23757841
108BMX0.23329820
109MAPKAPK20.22307019
110BCR0.21882092
111ARAF0.21821646
112CSNK1D0.21562220
113MAP3K60.21433013
114PDGFRA0.21375561
115KSR10.21313477
116TAOK10.21285112
117CDK180.20450372
118UHMK10.19690726
119IRAK30.19172682
120CDK140.17961221
121AKT10.17584699

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.18099166
2Mismatch repair_Homo sapiens_hsa034304.13679346
3* Cell cycle_Homo sapiens_hsa041103.67394991
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.39553478
5RNA transport_Homo sapiens_hsa030133.27831219
6Spliceosome_Homo sapiens_hsa030403.23112731
7Base excision repair_Homo sapiens_hsa034103.13199674
8Homologous recombination_Homo sapiens_hsa034403.12863093
9Nucleotide excision repair_Homo sapiens_hsa034202.85122610
10RNA polymerase_Homo sapiens_hsa030202.78146055
11Fanconi anemia pathway_Homo sapiens_hsa034602.49452103
12One carbon pool by folate_Homo sapiens_hsa006702.41580408
13Ribosome_Homo sapiens_hsa030102.38582095
14Pyrimidine metabolism_Homo sapiens_hsa002402.22032859
15Proteasome_Homo sapiens_hsa030502.12812896
16p53 signaling pathway_Homo sapiens_hsa041152.05898018
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.04609694
18Non-homologous end-joining_Homo sapiens_hsa034501.92377274
19mRNA surveillance pathway_Homo sapiens_hsa030151.89382793
20Systemic lupus erythematosus_Homo sapiens_hsa053221.88949006
21RNA degradation_Homo sapiens_hsa030181.86139124
22Basal transcription factors_Homo sapiens_hsa030221.84091314
23Vitamin B6 metabolism_Homo sapiens_hsa007501.82641121
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.65682926
25Oocyte meiosis_Homo sapiens_hsa041141.58108380
26* Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.48530637
27Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.32851840
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26544531
29* Viral carcinogenesis_Homo sapiens_hsa052031.22987229
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22455841
31Pyruvate metabolism_Homo sapiens_hsa006201.14911321
32* Epstein-Barr virus infection_Homo sapiens_hsa051691.14244481
33Purine metabolism_Homo sapiens_hsa002301.14159565
34MicroRNAs in cancer_Homo sapiens_hsa052061.03409346
35Herpes simplex infection_Homo sapiens_hsa051681.03203449
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.01709056
37Steroid biosynthesis_Homo sapiens_hsa001000.96470834
38HTLV-I infection_Homo sapiens_hsa051660.96115361
39Small cell lung cancer_Homo sapiens_hsa052220.95394160
40Protein export_Homo sapiens_hsa030600.89523669
41Alcoholism_Homo sapiens_hsa050340.86047093
42Pentose phosphate pathway_Homo sapiens_hsa000300.84288131
43Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80902515
44Antigen processing and presentation_Homo sapiens_hsa046120.80300869
45Folate biosynthesis_Homo sapiens_hsa007900.77530170
46Biosynthesis of amino acids_Homo sapiens_hsa012300.73853967
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.70694947
48Thyroid cancer_Homo sapiens_hsa052160.67910540
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66469569
50Colorectal cancer_Homo sapiens_hsa052100.65524885
51Chronic myeloid leukemia_Homo sapiens_hsa052200.65240244
52Selenocompound metabolism_Homo sapiens_hsa004500.64957069
53Huntingtons disease_Homo sapiens_hsa050160.63885136
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62060253
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61863403
56Fatty acid elongation_Homo sapiens_hsa000620.60948345
57TGF-beta signaling pathway_Homo sapiens_hsa043500.60423291
58Hippo signaling pathway_Homo sapiens_hsa043900.59656909
59Bladder cancer_Homo sapiens_hsa052190.59204550
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58245255
61Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54870913
62Drug metabolism - other enzymes_Homo sapiens_hsa009830.51713733
63Parkinsons disease_Homo sapiens_hsa050120.51625960
64Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51386968
65Apoptosis_Homo sapiens_hsa042100.51358335
66Basal cell carcinoma_Homo sapiens_hsa052170.49370490
67* Hepatitis B_Homo sapiens_hsa051610.49047108
68Sulfur relay system_Homo sapiens_hsa041220.48527230
69Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47957328
70Pancreatic cancer_Homo sapiens_hsa052120.45646314
71Notch signaling pathway_Homo sapiens_hsa043300.45353619
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.44971214
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.43998022
74Prostate cancer_Homo sapiens_hsa052150.43475608
75mTOR signaling pathway_Homo sapiens_hsa041500.43051337
76Non-small cell lung cancer_Homo sapiens_hsa052230.41033844
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40617185
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40362452
79Legionellosis_Homo sapiens_hsa051340.39099197
80Adherens junction_Homo sapiens_hsa045200.38860738
81Propanoate metabolism_Homo sapiens_hsa006400.37360521
82FoxO signaling pathway_Homo sapiens_hsa040680.37163878
83Shigellosis_Homo sapiens_hsa051310.37065775
84Pathways in cancer_Homo sapiens_hsa052000.34964376
85Hedgehog signaling pathway_Homo sapiens_hsa043400.34043192
86Primary immunodeficiency_Homo sapiens_hsa053400.33164806
87Measles_Homo sapiens_hsa051620.32330077
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.32116844
89Fructose and mannose metabolism_Homo sapiens_hsa000510.31637053
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31211973
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28899588
92Viral myocarditis_Homo sapiens_hsa054160.28886587
93Oxidative phosphorylation_Homo sapiens_hsa001900.28433563
94Galactose metabolism_Homo sapiens_hsa000520.28250892
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27906962
96Metabolic pathways_Homo sapiens_hsa011000.27863031
97HIF-1 signaling pathway_Homo sapiens_hsa040660.27624634
98NF-kappa B signaling pathway_Homo sapiens_hsa040640.26241278
99N-Glycan biosynthesis_Homo sapiens_hsa005100.25979069
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.25395091
101Carbon metabolism_Homo sapiens_hsa012000.25376012
102Glutathione metabolism_Homo sapiens_hsa004800.25251244
103Arginine and proline metabolism_Homo sapiens_hsa003300.23845105
104Influenza A_Homo sapiens_hsa051640.22931771
105Endometrial cancer_Homo sapiens_hsa052130.21894277
106Melanoma_Homo sapiens_hsa052180.21871853
107Lysine degradation_Homo sapiens_hsa003100.21417998
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20649284
109Proteoglycans in cancer_Homo sapiens_hsa052050.20469750
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.20129594
111Fatty acid metabolism_Homo sapiens_hsa012120.20008081
112Hematopoietic cell lineage_Homo sapiens_hsa046400.19102481
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17597694
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17574004
115Arginine biosynthesis_Homo sapiens_hsa002200.17493192
116Wnt signaling pathway_Homo sapiens_hsa043100.17313007
117Acute myeloid leukemia_Homo sapiens_hsa052210.17131603
118NOD-like receptor signaling pathway_Homo sapiens_hsa046210.16868999
119Renin-angiotensin system_Homo sapiens_hsa046140.16639534
120Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.15603797
121Glioma_Homo sapiens_hsa052140.15350134
122Tight junction_Homo sapiens_hsa045300.14886759
123Renal cell carcinoma_Homo sapiens_hsa052110.14840955
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.11334889
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.10096905
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.09856370

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