CCM2L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1lymph vessel development (GO:0001945)6.61646768
2endothelium development (GO:0003158)5.55104948
3vascular endothelial growth factor signaling pathway (GO:0038084)5.37488848
4blood vessel maturation (GO:0001955)5.19611660
5low-density lipoprotein particle clearance (GO:0034383)4.96824876
6surfactant homeostasis (GO:0043129)4.91666765
7positive regulation of vasculogenesis (GO:2001214)4.78482505
8cellular response to vascular endothelial growth factor stimulus (GO:0035924)4.66506363
9retina vasculature morphogenesis in camera-type eye (GO:0061299)4.50721911
10regulation of endothelial cell differentiation (GO:0045601)4.36688393
11morphogenesis of an endothelium (GO:0003159)4.35155776
12endothelial tube morphogenesis (GO:0061154)4.35155776
13positive regulation of protein kinase C signaling (GO:0090037)4.30774155
14heart trabecula formation (GO:0060347)4.29637494
15regulation of vasculogenesis (GO:2001212)4.27654442
16endothelial cell morphogenesis (GO:0001886)4.25250677
17ovulation from ovarian follicle (GO:0001542)4.14315554
18venous blood vessel morphogenesis (GO:0048845)4.11754593
19lymphangiogenesis (GO:0001946)4.08121240
20hyaluronan catabolic process (GO:0030214)3.92344539
21cardiac myofibril assembly (GO:0055003)3.90322477
22patterning of blood vessels (GO:0001569)3.90031411
23cAMP biosynthetic process (GO:0006171)3.87655751
24vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.82458748
25chemical homeostasis within a tissue (GO:0048875)3.76669867
26negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.75280937
27positive regulation of urine volume (GO:0035810)3.68779701
28positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.67956575
29sarcomere organization (GO:0045214)3.66993239
30basement membrane organization (GO:0071711)3.63979838
31peptidyl-tyrosine autophosphorylation (GO:0038083)3.62086921
32fatty acid transmembrane transport (GO:1902001)3.61495102
33definitive hemopoiesis (GO:0060216)3.54375463
34transcytosis (GO:0045056)3.53041692
35blood vessel endothelial cell migration (GO:0043534)3.50895126
36negative regulation of endothelial cell migration (GO:0010596)3.48936154
37endothelial cell chemotaxis (GO:0035767)3.48055573
38negative regulation of platelet activation (GO:0010544)3.42311117
39glomerular filtration (GO:0003094)3.41378054
40bundle of His cell to Purkinje myocyte communication (GO:0086069)3.41164630
41sarcoplasmic reticulum calcium ion transport (GO:0070296)3.39192891
42cellular response to cadmium ion (GO:0071276)3.38252900
43endothelial cell differentiation (GO:0045446)3.38062549
44negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.36418355
45myofibril assembly (GO:0030239)3.35540799
46complement activation, alternative pathway (GO:0006957)3.35067053
47vasculogenesis (GO:0001570)3.32433009
48cell migration involved in sprouting angiogenesis (GO:0002042)3.32290248
49negative regulation of amino acid transport (GO:0051956)3.31271364
50negative regulation of blood vessel endothelial cell migration (GO:0043537)3.31003276
51negative regulation of nitric-oxide synthase activity (GO:0051001)3.30677434
52carnitine shuttle (GO:0006853)3.30052811
53plasma membrane repair (GO:0001778)3.26358567
54diacylglycerol metabolic process (GO:0046339)3.25613950
55renal filtration (GO:0097205)3.24535305
56regulation of membrane protein ectodomain proteolysis (GO:0051043)3.23938861
57protein kinase C signaling (GO:0070528)3.20484431
58response to dietary excess (GO:0002021)3.19973850
59Notch signaling involved in heart development (GO:0061314)3.19760977
60regulation of actin filament-based movement (GO:1903115)3.15748234
61angiogenesis involved in wound healing (GO:0060055)3.14491034
62neuron projection extension involved in neuron projection guidance (GO:1902284)3.11867751
63axon extension involved in axon guidance (GO:0048846)3.11867751
64regulation of female gonad development (GO:2000194)3.08607728
65regulation of p38MAPK cascade (GO:1900744)3.07410389
66barbed-end actin filament capping (GO:0051016)3.02563660
67regulation of sequestering of triglyceride (GO:0010889)3.01454146
68cGMP-mediated signaling (GO:0019934)2.98972991
69muscle filament sliding (GO:0030049)2.96968013
70actin-myosin filament sliding (GO:0033275)2.96968013
71positive regulation of heat generation (GO:0031652)2.96243509
72fatty acid beta-oxidation (GO:0006635)2.95798703
73semaphorin-plexin signaling pathway (GO:0071526)2.95335413
74regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.93583137
75triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.91518525
76sprouting angiogenesis (GO:0002040)2.90525792
77regulation of sarcomere organization (GO:0060297)2.90179105
78establishment of endothelial barrier (GO:0061028)2.88253212
79labyrinthine layer development (GO:0060711)2.86426054
80negative regulation of focal adhesion assembly (GO:0051895)2.85844032
81negative regulation of cell junction assembly (GO:1901889)2.85844032
82negative regulation of adherens junction organization (GO:1903392)2.85844032
83ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.84288859
84lysine metabolic process (GO:0006553)2.82142470
85lysine catabolic process (GO:0006554)2.82142470
86regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.81372514
87endothelial cell migration (GO:0043542)2.80769815
88cardiac muscle tissue morphogenesis (GO:0055008)2.79840105
89mRNA transcription from RNA polymerase II promoter (GO:0042789)2.79549099
90NADH metabolic process (GO:0006734)2.79330390
912-oxoglutarate metabolic process (GO:0006103)2.79107209
92cardiac muscle cell proliferation (GO:0060038)2.77022942
93regulation of fever generation (GO:0031620)2.76383951
94regulation of cholesterol storage (GO:0010885)2.75924341
95virion attachment to host cell (GO:0019062)2.75819861
96adhesion of symbiont to host cell (GO:0044650)2.75819861
97negative regulation of DNA biosynthetic process (GO:2000279)2.75222059
98regulation of protein kinase C signaling (GO:0090036)2.74122908
99negative regulation of endothelial cell apoptotic process (GO:2000352)2.73696781
100regulation of urine volume (GO:0035809)2.73596959
101cell migration involved in heart development (GO:0060973)2.73472678
102arginine catabolic process (GO:0006527)2.70362568
103blood vessel remodeling (GO:0001974)2.69917337
104negative regulation of macrophage differentiation (GO:0045650)2.69882379
105regulation of macrophage chemotaxis (GO:0010758)2.68581829
106actin-mediated cell contraction (GO:0070252)2.67843533
107regulation of phospholipid biosynthetic process (GO:0071071)2.67239369
108adherens junction assembly (GO:0034333)2.66768149
109coronary vasculature morphogenesis (GO:0060977)2.66093105
110cholesterol catabolic process (GO:0006707)2.64969572
111sterol catabolic process (GO:0016127)2.64969572
112regulation of relaxation of muscle (GO:1901077)2.63461591
113negative regulation of endothelial cell proliferation (GO:0001937)2.63336149
114fatty acid oxidation (GO:0019395)2.62896521
115neuron remodeling (GO:0016322)2.62662302
116cardiac muscle contraction (GO:0060048)2.62103923
117regulation of vascular permeability (GO:0043114)2.61065885
118mRNA transcription (GO:0009299)2.60264132
119regulation of complement activation (GO:0030449)2.60192138
120regulation of the force of heart contraction (GO:0002026)2.59442825
121regulation of protein activation cascade (GO:2000257)2.58603330
122regulation of blood vessel endothelial cell migration (GO:0043535)2.58429177
123embryonic heart tube development (GO:0035050)2.57257890
124negative regulation of homotypic cell-cell adhesion (GO:0034111)2.57085667
125regulation of endothelial cell chemotaxis (GO:2001026)2.56747111
126regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.55884358
127positive regulation of endothelial cell differentiation (GO:0045603)2.55778200
128lipid oxidation (GO:0034440)2.55614667
129epoxygenase P450 pathway (GO:0019373)2.55195220
130negative regulation of epithelial cell migration (GO:0010633)2.54837077
131actomyosin structure organization (GO:0031032)2.54814078
132fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.54704165
133regulation of DNA methylation (GO:0044030)2.54681105
134regulation of cardiac muscle cell contraction (GO:0086004)2.54584748
135paraxial mesoderm development (GO:0048339)2.53793864
136ganglion development (GO:0061548)2.53464747
137response to mercury ion (GO:0046689)2.53413854
138regulation of mononuclear cell migration (GO:0071675)2.52988361
139carnitine transmembrane transport (GO:1902603)2.52975489
140carnitine metabolic process (GO:0009437)2.52900456
141ovulation (GO:0030728)2.52489945
142negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.52430529
143negative regulation of vascular permeability (GO:0043116)2.52209407
144muscle tissue morphogenesis (GO:0060415)2.51526935
145positive regulation of lipid storage (GO:0010884)2.50826576
146tricarboxylic acid cycle (GO:0006099)2.49560554
147cardiac muscle hypertrophy (GO:0003300)2.48981677
148regulation of endothelial cell migration (GO:0010594)2.47482989
149adhesion of symbiont to host (GO:0044406)2.47329138
150negative regulation of smooth muscle cell proliferation (GO:0048662)2.45485736
151regulation of synapse maturation (GO:0090128)2.45210905
152heart contraction (GO:0060047)2.44484629
153heart process (GO:0003015)2.44484629
154positive regulation of glomerulus development (GO:0090193)2.43296478
155polyol transport (GO:0015791)2.41124858
156negative regulation of heart growth (GO:0061117)2.40956333
157negative regulation of cardiac muscle tissue growth (GO:0055022)2.40956333
158growth hormone secretion (GO:0030252)2.40627198

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.13050752
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.82348442
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.53907244
4EZH2_22144423_ChIP-Seq_EOC_Human4.35622489
5GATA2_21666600_ChIP-Seq_HMVEC_Human3.34697406
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.32585418
7RXR_22158963_ChIP-Seq_LIVER_Mouse3.24540514
8CLOCK_20551151_ChIP-Seq_293T_Human3.16899489
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.04585676
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.04585676
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.04585676
12GATA1_22025678_ChIP-Seq_K562_Human2.95161283
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.94786357
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.93438777
15SCL_19346495_ChIP-Seq_HPC-7_Human2.78408535
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.67821236
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.43883097
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.40853511
19FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.38897880
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.38188630
21TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.36958677
22EP300_21415370_ChIP-Seq_HL-1_Mouse2.30805966
23STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.29352872
24TBX20_22328084_ChIP-Seq_HEART_Mouse2.10947288
25TBX20_22080862_ChIP-Seq_HEART_Mouse2.10947288
26NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.07296745
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06564407
28ZNF263_19887448_ChIP-Seq_K562_Human1.97818728
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.97408535
30STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.94362676
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.92608100
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90147529
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79182737
34TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.75221522
35GATA1_19941826_ChIP-Seq_K562_Human1.70540696
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.70333748
37TP63_17297297_ChIP-ChIP_HaCaT_Human1.64678654
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.63539925
39NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.61904972
40EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.61559797
41SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.60867499
42ZFP281_18757296_ChIP-ChIP_E14_Mouse1.59901604
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59438778
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.49631255
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.49580293
46ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46504595
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.45693298
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44241613
49DNAJC2_21179169_ChIP-ChIP_NT2_Human1.41666495
50TCF7_22412390_ChIP-Seq_EML_Mouse1.40321924
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39952805
52LXR_22292898_ChIP-Seq_THP-1_Human1.39708613
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.39605753
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.39605753
55IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39023564
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.38782705
57CDX2_20551321_ChIP-Seq_CACO-2_Human1.37747174
58RUNX_20019798_ChIP-Seq_JUKART_Human1.35656461
59CTCF_27219007_Chip-Seq_Bcells_Human1.34387091
60BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31111829
61GATA2_19941826_ChIP-Seq_K562_Human1.31071974
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.29915525
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28563983
64HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.28539509
65PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27467891
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24189348
67NFIB_24661679_ChIP-Seq_LUNG_Mouse1.23543236
68SPI1_23127762_ChIP-Seq_K562_Human1.22313604
69SMC3_22415368_ChIP-Seq_MEFs_Mouse1.21381193
70KDM2B_26808549_Chip-Seq_DND41_Human1.19812036
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.18769562
72SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.18714506
73SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17739284
74EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16860999
75SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.16677845
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16570897
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.16536324
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.16318810
79HIF1A_21447827_ChIP-Seq_MCF-7_Human1.15724500
80EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15199939
81MTF2_20144788_ChIP-Seq_MESCs_Mouse1.14536749
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.14170194
83SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11652085
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11265262
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.10948816
86SUZ12_27294783_Chip-Seq_ESCs_Mouse1.10770334
87RAD21_21589869_ChIP-Seq_MESCs_Mouse1.10311607
88EED_16625203_ChIP-ChIP_MESCs_Mouse1.09532133
89RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09163225
90RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.09054907
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08974791
92P68_20966046_ChIP-Seq_HELA_Human1.08941190
93SALL4_18804426_ChIP-ChIP_XEN_Mouse1.06849180
94FOXO3_23340844_ChIP-Seq_DLD1_Human1.06537754
95PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.06511458
96PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.05784576
97FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.05383621
98KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05287177
99RACK7_27058665_Chip-Seq_MCF-7_Human1.05142216
100EGR1_19374776_ChIP-ChIP_THP-1_Human1.04826682
101TET1_21451524_ChIP-Seq_MESCs_Mouse1.04609780
102CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04506490
103FOXA2_19822575_ChIP-Seq_HepG2_Human1.04166840
104MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03880038
105TET1_21490601_ChIP-Seq_MESCs_Mouse1.03079572
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02930224
107STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.02854146
108SMC4_20622854_ChIP-Seq_HELA_Human1.00696241
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00356182
110KDM2B_26808549_Chip-Seq_K562_Human1.00088704
111RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.98264094
112TP53_20018659_ChIP-ChIP_R1E_Mouse0.97955348
113CJUN_26792858_Chip-Seq_BT549_Human0.97600330
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97209552
115CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96989825
116SA1_22415368_ChIP-Seq_MEFs_Mouse0.96714648
117ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.96138329
118KDM2B_26808549_Chip-Seq_JURKAT_Human0.95549629
119CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93825355
120SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92275426
121OCT4_19829295_ChIP-Seq_ESCs_Human0.92074660
122CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91873798
123JARID2_20075857_ChIP-Seq_MESCs_Mouse0.91858342
124CTCF_26484167_Chip-Seq_Bcells_Mouse0.91207780
125SOX2_20726797_ChIP-Seq_SW620_Human0.90971083
126SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90256618
127EZH2_27304074_Chip-Seq_ESCs_Mouse0.90067935
128SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88715270
129KLF4_19829295_ChIP-Seq_ESCs_Human0.88443843
130LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88435776
131NCOR1_26117541_ChIP-Seq_K562_Human0.87821879
132SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.87666273
133MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.87641806
134CTCF_21964334_Chip-Seq_Bcells_Human0.86513842
135SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.86049681
136WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85749885
137SMC1_22415368_ChIP-Seq_MEFs_Mouse0.85692890
138MAF_26560356_Chip-Seq_TH1_Human0.85380881
139ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.85161099
140TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84946736
141SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.83960567
142WT1_19549856_ChIP-ChIP_CCG9911_Human0.83943888
143WT1_25993318_ChIP-Seq_PODOCYTE_Human0.82533319
144TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81635306
145SOX9_24532713_ChIP-Seq_HFSC_Mouse0.81622615
146GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80822146
147SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.79937655
148FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79797301
149DROSHA_22980978_ChIP-Seq_HELA_Human0.78871199
150PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.78821832
151VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.77520182
152RUNX1_27514584_Chip-Seq_MCF-7_Human0.76529665
153CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.75333157
154TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.74947250
155IRF8_22096565_ChIP-ChIP_GC-B_Human0.74896953
156TCF4_18268006_ChIP-ChIP_LS174T_Human0.74853652
157SPI1_20517297_ChIP-Seq_HL60_Human0.74696029

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system6.42438527
2MP0001879_abnormal_lymphatic_vessel4.78716536
3MP0005167_abnormal_blood-brain_barrier4.48828507
4MP0004084_abnormal_cardiac_muscle3.98821564
5MP0004272_abnormal_basement_membrane3.03282718
6MP0002837_dystrophic_cardiac_calcinosis2.93124099
7MP0003828_pulmonary_edema2.92059229
8MP0004036_abnormal_muscle_relaxation2.72896159
9MP0000751_myopathy2.55652020
10MP0003724_increased_susceptibility_to2.47354110
11MP0006138_congestive_heart_failure2.45726859
12MP0004215_abnormal_myocardial_fiber2.40161416
13MP0005330_cardiomyopathy2.23761783
14MP0002254_reproductive_system_inflammat2.23333714
15MP0000767_abnormal_smooth_muscle2.08351879
16MP0005385_cardiovascular_system_phenoty2.05014008
17MP0001544_abnormal_cardiovascular_syste2.05014008
18MP0005360_urolithiasis2.02680760
19MP0005058_abnormal_lysosome_morphology2.01009790
20MP0005409_darkened_coat_color1.98512078
21MP0008775_abnormal_heart_ventricle1.98154563
22MP0003191_abnormal_cellular_cholesterol1.95242949
23MP0009840_abnormal_foam_cell1.94634022
24MP0010630_abnormal_cardiac_muscle1.94090347
25MP0003279_aneurysm1.91004056
26MP0004147_increased_porphyrin_level1.88971717
27MP0003646_muscle_fatigue1.83797922
28MP0004130_abnormal_muscle_cell1.81358568
29MP0002972_abnormal_cardiac_muscle1.77206000
30MP0003705_abnormal_hypodermis_morpholog1.73707765
31MP0005085_abnormal_gallbladder_physiolo1.71008483
32MP0004484_altered_response_of1.70371316
33MP0000749_muscle_degeneration1.68223657
34MP0002138_abnormal_hepatobiliary_system1.67884734
35MP0003950_abnormal_plasma_membrane1.63331631
36MP0000343_altered_response_to1.61145621
37MP0004087_abnormal_muscle_fiber1.61059358
38MP0000249_abnormal_blood_vessel1.59698573
39MP0008875_abnormal_xenobiotic_pharmacok1.56458347
40MP0008004_abnormal_stomach_pH1.52581700
41MP0004085_abnormal_heartbeat1.51814937
42MP0002139_abnormal_hepatobiliary_system1.49754839
43MP0005165_increased_susceptibility_to1.47828443
44MP0005620_abnormal_muscle_contractility1.45815082
45MP0005670_abnormal_white_adipose1.42555318
46MP0002128_abnormal_blood_circulation1.42339970
47MP0006054_spinal_hemorrhage1.40385447
48MP0002127_abnormal_cardiovascular_syste1.40278355
49MP0004510_myositis1.38076087
50MP0009278_abnormal_bone_marrow1.37436634
51MP0005451_abnormal_body_composition1.36560655
52MP0002332_abnormal_exercise_endurance1.35052086
53MP0005365_abnormal_bile_salt1.34341856
54MP0001849_ear_inflammation1.31242576
55MP0002108_abnormal_muscle_morphology1.29563458
56MP0003566_abnormal_cell_adhesion1.28994826
57MP0004185_abnormal_adipocyte_glucose1.26729276
58MP0003690_abnormal_glial_cell1.25672509
59MP0001958_emphysema1.25312957
60MP0010329_abnormal_lipoprotein_level1.25280925
61MP0000003_abnormal_adipose_tissue1.23296957
62MP0000750_abnormal_muscle_regeneration1.21942761
63MP0005595_abnormal_vascular_smooth1.20264843
64MP0003567_abnormal_fetal_cardiomyocyte1.19887700
65MP0004233_abnormal_muscle_weight1.19547047
66MP0009697_abnormal_copulation1.19450685
67MP0002106_abnormal_muscle_physiology1.17114311
68MP0001614_abnormal_blood_vessel1.13289506
69MP0009379_abnormal_foot_pigmentation1.11505911
70MP0000465_gastrointestinal_hemorrhage1.11422498
71MP0005083_abnormal_biliary_tract1.11197191
72MP0010030_abnormal_orbit_morphology1.10966494
73MP0002925_abnormal_cardiovascular_devel1.09614552
74MP0000013_abnormal_adipose_tissue1.06969414
75MP0000266_abnormal_heart_morphology1.06916330
76MP0000230_abnormal_systemic_arterial1.06313801
77MP0004782_abnormal_surfactant_physiolog1.05393416
78MP0002998_abnormal_bone_remodeling1.02438495
79MP0003718_maternal_effect1.00855376
80MP0003879_abnormal_hair_cell1.00321666
81MP0003252_abnormal_bile_duct0.99870528
82MP0003011_delayed_dark_adaptation0.99470990
83MP0005666_abnormal_adipose_tissue0.97010736
84MP0001501_abnormal_sleep_pattern0.96866449
85MP0003186_abnormal_redox_activity0.96136036
86MP0002933_joint_inflammation0.95234398
87MP0004883_abnormal_blood_vessel0.94749260
88MP0005319_abnormal_enzyme/_coenzyme0.91699081
89MP0003453_abnormal_keratinocyte_physiol0.91465832
90MP0005369_muscle_phenotype0.91331931
91MP0005084_abnormal_gallbladder_morpholo0.90076880
92MP0003091_abnormal_cell_migration0.89200167
93MP0005535_abnormal_body_temperature0.88910532
94MP0004808_abnormal_hematopoietic_stem0.88673856
95MP0009115_abnormal_fat_cell0.86408099
96MP0005166_decreased_susceptibility_to0.85852256
97MP0008961_abnormal_basal_metabolism0.85341671
98MP0003137_abnormal_impulse_conducting0.84123934
99MP0001545_abnormal_hematopoietic_system0.83618605
100MP0005397_hematopoietic_system_phenotyp0.83618605
101MP0000747_muscle_weakness0.83390831
102MP0003806_abnormal_nucleotide_metabolis0.81521915
103MP0006036_abnormal_mitochondrial_physio0.81402488
104MP0003303_peritoneal_inflammation0.80577164
105MP0009643_abnormal_urine_homeostasis0.79974166
106MP0005623_abnormal_meninges_morphology0.79300844
107MP0005647_abnormal_sex_gland0.79289384
108MP0001727_abnormal_embryo_implantation0.79236495
109MP0000759_abnormal_skeletal_muscle0.78990593
110MP0005334_abnormal_fat_pad0.78568116
111MP0002118_abnormal_lipid_homeostasis0.78332461
112MP0003941_abnormal_skin_development0.77296441
113MP0003638_abnormal_response/metabolism_0.76479355
114MP0002295_abnormal_pulmonary_circulatio0.74966455
115MP0005266_abnormal_metabolism0.73684695
116MP0009764_decreased_sensitivity_to0.73217414
117MP0005164_abnormal_response_to0.72132779
118MP0009785_altered_susceptibility_to0.70930566
119MP0003948_abnormal_gas_homeostasis0.70718127
120MP0008874_decreased_physiological_sensi0.69484344
121MP0008438_abnormal_cutaneous_collagen0.68002983
122MP0001915_intracranial_hemorrhage0.67828347
123MP0003300_gastrointestinal_ulcer0.67315502
124MP0002269_muscular_atrophy0.66956844
125MP0003075_altered_response_to0.66884975
126MP0005375_adipose_tissue_phenotype0.66330754
127MP0002971_abnormal_brown_adipose0.64939017
128MP0002148_abnormal_hypersensitivity_rea0.64242187
129MP0003943_abnormal_hepatobiliary_system0.63933471
130MP0006276_abnormal_autonomic_nervous0.63564326
131MP0000609_abnormal_liver_physiology0.62678998
132MP0005187_abnormal_penis_morphology0.62519108
133MP0001784_abnormal_fluid_regulation0.62433975
134MP0001851_eye_inflammation0.62221960
135MP0005332_abnormal_amino_acid0.61758166
136MP0004145_abnormal_muscle_electrophysio0.61228631
137MP0003136_yellow_coat_color0.60890496
138MP0001533_abnormal_skeleton_physiology0.59643778
139MP0008260_abnormal_autophagy0.59188096

Predicted human phenotypes

RankGene SetZ-score
1Polycythemia (HP:0001901)5.91075005
2Spontaneous hematomas (HP:0007420)5.38019935
3Hematochezia (HP:0002573)4.52037836
4Sudden death (HP:0001699)4.44101414
5Ventricular tachycardia (HP:0004756)4.35117028
6Esophageal varix (HP:0002040)4.32826208
7Deep venous thrombosis (HP:0002625)4.31844554
8Muscle fiber splitting (HP:0003555)4.19069371
9Abnormality of the nasal mucosa (HP:0000433)3.88337682
10Atrial fibrillation (HP:0005110)3.76483362
11Nuclear cataract (HP:0100018)3.76277405
12Centrally nucleated skeletal muscle fibers (HP:0003687)3.61801840
13Broad metatarsal (HP:0001783)3.58645297
14Supraventricular arrhythmia (HP:0005115)3.48459685
15Cerebral hemorrhage (HP:0001342)3.44867081
16Primary atrial arrhythmia (HP:0001692)3.42608765
17Calf muscle hypertrophy (HP:0008981)3.40086717
18Hyporeflexia of lower limbs (HP:0002600)3.31807200
19Supraventricular tachycardia (HP:0004755)3.31129705
20Lipoatrophy (HP:0100578)3.31085909
21Lymphangioma (HP:0100764)3.29727953
22Increased connective tissue (HP:0009025)3.26246703
23Delayed CNS myelination (HP:0002188)3.24394626
24Skull defect (HP:0001362)3.23407491
25Axonal loss (HP:0003447)3.14845286
26Exercise-induced myalgia (HP:0003738)3.13193368
27Myoglobinuria (HP:0002913)3.12325796
28Conjunctival telangiectasia (HP:0000524)3.09047702
29Spinal rigidity (HP:0003306)3.04924104
30Facial diplegia (HP:0001349)3.03399466
31Exercise-induced muscle cramps (HP:0003710)3.03143409
32Muscle hypertrophy of the lower extremities (HP:0008968)3.02197610
33Complement deficiency (HP:0004431)2.99495333
34Difficulty running (HP:0009046)2.98443335
35Muscle fiber inclusion bodies (HP:0100299)2.97825620
36Visceral angiomatosis (HP:0100761)2.97822357
37Asymmetric septal hypertrophy (HP:0001670)2.94453958
38Cerebral aneurysm (HP:0004944)2.94127122
39Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.92729874
40Joint hemorrhage (HP:0005261)2.89315895
41Right ventricular cardiomyopathy (HP:0011663)2.88791737
42Atrioventricular block (HP:0001678)2.84340302
43Rimmed vacuoles (HP:0003805)2.83688055
44Portal hypertension (HP:0001409)2.82664635
45EMG: myopathic abnormalities (HP:0003458)2.82515564
46Hemangiomatosis (HP:0007461)2.81486092
47Oligomenorrhea (HP:0000876)2.78326775
48Hypoglycemic coma (HP:0001325)2.77384755
49Dilated cardiomyopathy (HP:0001644)2.72184735
50Neurofibrillary tangles (HP:0002185)2.68726651
51Bulbar palsy (HP:0001283)2.68383374
52Cavernous hemangioma (HP:0001048)2.67560751
53Apathy (HP:0000741)2.61383704
54Ketoacidosis (HP:0001993)2.60619390
55Nemaline bodies (HP:0003798)2.60027431
56Subaortic stenosis (HP:0001682)2.58513253
57Abnormality of the left ventricular outflow tract (HP:0011103)2.58513253
58Abnormality of liposaccharide metabolism (HP:0010968)2.58038868
59Abnormality of glycosphingolipid metabolism (HP:0004343)2.58038868
60Abnormality of glycolipid metabolism (HP:0010969)2.58038868
61Absent hand (HP:0004050)2.56869451
62Abnormality of the vasculature of the conjunctiva (HP:0008054)2.56158776
63Heart block (HP:0012722)2.55327050
64Myotonia (HP:0002486)2.49980315
65Abnormality of the hepatic vasculature (HP:0006707)2.49819905
66Prolonged bleeding time (HP:0003010)2.49360454
67Systemic lupus erythematosus (HP:0002725)2.48247937
68Abnormality of the calf musculature (HP:0001430)2.48192183
69Abnormality of fatty-acid metabolism (HP:0004359)2.45751754
70Type 1 muscle fiber predominance (HP:0003803)2.43799945
71Mutism (HP:0002300)2.41894006
72Capillary hemangiomas (HP:0005306)2.40501046
73Syncope (HP:0001279)2.40052011
74Palpitations (HP:0001962)2.39560466
75Rhabdomyolysis (HP:0003201)2.39240040
76Neck muscle weakness (HP:0000467)2.37588035
77Hemorrhage of the eye (HP:0011885)2.37125129
78Abnormality of skeletal muscle fiber size (HP:0012084)2.37114345
79Menorrhagia (HP:0000132)2.36608659
80Abnormal atrioventricular conduction (HP:0005150)2.36107451
81Abnormality of complement system (HP:0005339)2.35660421
82Stridor (HP:0010307)2.35569602
83Diminished motivation (HP:0000745)2.35492538
84Ketosis (HP:0001946)2.35302175
85Wrist flexion contracture (HP:0001239)2.35220254
86Glomerulonephritis (HP:0000099)2.34877187
87Pulmonary embolism (HP:0002204)2.32006296
88Increased variability in muscle fiber diameter (HP:0003557)2.31861825
89Bundle branch block (HP:0011710)2.28505612
90Amyloidosis (HP:0011034)2.28435059
91Microcytic anemia (HP:0001935)2.27618863
92Pulmonary artery stenosis (HP:0004415)2.26478763
93Foot dorsiflexor weakness (HP:0009027)2.23917516
94Cerebral inclusion bodies (HP:0100314)2.20310936
95Frequent falls (HP:0002359)2.20164717
96Mucosal telangiectasiae (HP:0100579)2.20133750
97Scapular winging (HP:0003691)2.19640262
98Hyperglycinuria (HP:0003108)2.19441917
99Recurrent gram-negative bacterial infections (HP:0005420)2.18327921
100Prolonged QT interval (HP:0001657)2.18210705
101Hypertriglyceridemia (HP:0002155)2.17551206
102Neonatal death (HP:0003811)2.13962545
103Aneurysm (HP:0002617)2.12911933
104Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.11826208
105Abnormality of the foot musculature (HP:0001436)2.10803860
106Difficulty climbing stairs (HP:0003551)2.09010238
107Polygenic inheritance (HP:0010982)2.08366237
108Hyperammonemia (HP:0001987)2.08338844
109Loss of speech (HP:0002371)2.07615879
110Myopathic facies (HP:0002058)2.06355838
111Prolonged partial thromboplastin time (HP:0003645)2.06133008
112Myocardial infarction (HP:0001658)2.05347452
113Nonimmune hydrops fetalis (HP:0001790)2.05131357
114Abnormality of lateral ventricle (HP:0030047)2.05073425
115Nephritis (HP:0000123)2.03663561
116Shallow orbits (HP:0000586)2.03343242
117Thrombophlebitis (HP:0004418)2.03272420
118Limb-girdle muscle atrophy (HP:0003797)2.02664255
119Absent eyebrow (HP:0002223)2.01763907
120Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.00894918
121Abnormality of dicarboxylic acid metabolism (HP:0010995)1.99195021
122Dicarboxylic aciduria (HP:0003215)1.99195021
123Hyperlipoproteinemia (HP:0010980)1.98726303
124Epistaxis (HP:0000421)1.98526893
125Stroke (HP:0001297)1.98484739
126Abnormality of the intrinsic pathway (HP:0010989)1.98080665
127Xanthomatosis (HP:0000991)1.97928868
128Malignant hyperthermia (HP:0002047)1.95594673
129Impaired platelet aggregation (HP:0003540)1.95469433
130Abnormal platelet function (HP:0011869)1.95469433
131Distal lower limb muscle weakness (HP:0009053)1.95311476
132Ulnar claw (HP:0001178)1.95289974
133Intrahepatic cholestasis (HP:0001406)1.93040308
134Rapidly progressive (HP:0003678)1.93019778
135Abnormality of the shoulder girdle musculature (HP:0001435)1.89185878
136Mesangial abnormality (HP:0001966)1.88781921
137Abnormality of aromatic amino acid family metabolism (HP:0004338)1.88752256
138Increased muscle lipid content (HP:0009058)1.87656543
139Diaphragmatic weakness (HP:0009113)1.86109010
140Abnormality of the common coagulation pathway (HP:0010990)1.85747159
141Nausea (HP:0002018)1.84549417
142Muscular dystrophy (HP:0003560)1.84390914
143Adactyly (HP:0009776)1.82697306
144Growth hormone excess (HP:0000845)1.80929242
145Ventricular arrhythmia (HP:0004308)1.79872310
146Porencephaly (HP:0002132)1.79680264
147Muscle stiffness (HP:0003552)1.79149161

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE19.66264468
2KDR4.93670383
3TGFBR24.14186477
4TGFBR13.05864001
5TTN2.55082609
6TRIB32.46716731
7PKN22.46527184
8RIPK12.38409732
9MAP3K132.14932340
10MYLK2.06404520
11MAP2K32.01694618
12PTK2B1.94036847
13TYRO31.93605087
14LATS21.91206065
15BCKDK1.76715436
16TESK21.76365942
17DDR21.75923716
18ERN11.75608727
19ARAF1.75107670
20IRAK31.71198520
21EPHB21.66159156
22DMPK1.58765561
23MOS1.51387263
24PTK61.40747937
25MAPK121.33248008
26CDC42BPA1.29833223
27NME21.29366780
28PDK21.25304397
29GRK11.24518394
30MAP3K91.24451017
31PRKG21.20813801
32FGFR41.16575206
33OBSCN1.12484892
34PHKG21.07947576
35PHKG11.07947576
36EPHB11.06886065
37MAP3K31.05328243
38LRRK21.02844406
39PRKD11.00700701
40MAP4K10.94347155
41LMTK20.92947533
42INSRR0.90993787
43MAP3K110.89313188
44TAOK20.88603163
45PDK30.88512832
46PDK40.88512832
47PRKAA20.86457779
48FGFR30.86187946
49PAK40.82774398
50PDGFRA0.81416463
51ABL20.80173288
52MAP3K100.78434041
53CAMK1D0.76472165
54KSR20.76449492
55TESK10.75022335
56PKN10.74068792
57CSK0.72419128
58MUSK0.72347094
59DAPK30.72127702
60MARK20.70975504
61MAP3K70.70644243
62MST1R0.69901448
63MAPKAPK30.68246117
64CAMK1G0.67116021
65PIK3CA0.63359586
66RPS6KA20.63109538
67PDPK10.63032723
68TAOK10.62605464
69FER0.61172354
70PRKCH0.60707283
71CAMK40.60070555
72MARK30.59912347
73KIT0.59192507
74CDK90.58933708
75BRAF0.57414414
76PINK10.57312173
77FGR0.56843687
78TBK10.54764248
79MAPK70.54546642
80NEK90.53742778
81WNK40.53657457
82MET0.52549169
83FGFR20.52169973
84FES0.52109401
85NTRK30.50606454
86ILK0.50312236
87ICK0.50276840
88MAP3K140.50246144
89GRK50.50108293
90TEC0.49526177
91SIK10.49464600
92PRPF4B0.47818792
93CDK190.47368732
94DYRK30.45551376
95CSNK1A1L0.45095892
96PTK20.43222835
97CAMK10.43094442
98MAPK40.42388109
99NTRK10.42280149
100CDK50.42140860
101MAP3K60.40733688
102RET0.40710462
103ZAP700.40279212
104PDGFRB0.39686856
105PDK10.39522974
106MATK0.38241849
107CSNK1G30.37813266
108IGF1R0.37370523
109CSNK1G10.37245818
110AKT20.36935011
111MAP3K10.36558060
112FLT30.36328853
113PRKG10.36318797
114SGK30.36270455
115MAP2K60.35966776
116PAK10.35131384
117MTOR0.34974279
118IRAK40.34241000
119CHUK0.34138459
120EGFR0.33751045
121CDK60.33612084
122MARK10.32599674
123GRK70.31468068
124TRPM70.30435358
125DAPK20.30046166
126ROCK20.29571816
127JAK20.28446452
128BTK0.28267280
129PRKAA10.27878757
130SGK4940.27703034
131SGK2230.27703034
132TYK20.27251167
133CAMK2G0.25808340
134PRKD30.24433467
135ROCK10.24410320
136SRC0.24205802
137PRKACB0.24198790
138GSK3A0.24037312
139EEF2K0.23707950
140MAP2K20.22921326
141RPS6KA60.22350477
142IKBKE0.22076338
143CDK40.21944024
144TAOK30.21888762
145JAK30.21863833
146MAP2K40.21427167
147JAK10.21317764

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid degradation_Homo sapiens_hsa000713.08801947
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.84164612
3Complement and coagulation cascades_Homo sapiens_hsa046102.69927590
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.58003960
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.55765878
6Propanoate metabolism_Homo sapiens_hsa006402.55329050
7Arginine biosynthesis_Homo sapiens_hsa002202.53731970
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.40725399
9Staphylococcus aureus infection_Homo sapiens_hsa051502.36573600
10Tryptophan metabolism_Homo sapiens_hsa003802.21961913
11Nitrogen metabolism_Homo sapiens_hsa009102.17205630
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.08643929
13PPAR signaling pathway_Homo sapiens_hsa033202.04303134
14Dilated cardiomyopathy_Homo sapiens_hsa054141.98171102
15Fatty acid metabolism_Homo sapiens_hsa012121.93038123
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.88116291
17Caffeine metabolism_Homo sapiens_hsa002321.83721460
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.79612943
19Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69769383
20Tight junction_Homo sapiens_hsa045301.52044856
21Salmonella infection_Homo sapiens_hsa051321.45352364
22Bile secretion_Homo sapiens_hsa049761.45346975
23ECM-receptor interaction_Homo sapiens_hsa045121.43232595
24Focal adhesion_Homo sapiens_hsa045101.41592255
25Gap junction_Homo sapiens_hsa045401.34000627
26beta-Alanine metabolism_Homo sapiens_hsa004101.33215032
27Leukocyte transendothelial migration_Homo sapiens_hsa046701.33209618
28Pyruvate metabolism_Homo sapiens_hsa006201.33092280
29Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.32074385
30Insulin resistance_Homo sapiens_hsa049311.31599066
31Carbon metabolism_Homo sapiens_hsa012001.31272247
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.30708739
33Lysosome_Homo sapiens_hsa041421.28684034
34TNF signaling pathway_Homo sapiens_hsa046681.26104371
35Toll-like receptor signaling pathway_Homo sapiens_hsa046201.25925023
36Butanoate metabolism_Homo sapiens_hsa006501.25118816
37Axon guidance_Homo sapiens_hsa043601.21361186
38Starch and sucrose metabolism_Homo sapiens_hsa005001.18518430
39Platelet activation_Homo sapiens_hsa046111.16875954
40Rheumatoid arthritis_Homo sapiens_hsa053231.16584112
41Adipocytokine signaling pathway_Homo sapiens_hsa049201.16455527
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15920145
43Peroxisome_Homo sapiens_hsa041461.14175062
44Lysine degradation_Homo sapiens_hsa003101.12567529
45Cardiac muscle contraction_Homo sapiens_hsa042601.12171550
46ABC transporters_Homo sapiens_hsa020101.12149118
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08960572
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.08726141
49Oxytocin signaling pathway_Homo sapiens_hsa049211.02863911
50Notch signaling pathway_Homo sapiens_hsa043300.98451894
51Histidine metabolism_Homo sapiens_hsa003400.92643637
52Chemokine signaling pathway_Homo sapiens_hsa040620.91063535
53Fatty acid elongation_Homo sapiens_hsa000620.90523149
54Viral myocarditis_Homo sapiens_hsa054160.90150741
55Amoebiasis_Homo sapiens_hsa051460.86990294
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86814269
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86575459
58Arginine and proline metabolism_Homo sapiens_hsa003300.85540582
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.85510785
60Ovarian steroidogenesis_Homo sapiens_hsa049130.82740188
61Ras signaling pathway_Homo sapiens_hsa040140.82505094
62Rap1 signaling pathway_Homo sapiens_hsa040150.79014720
63Fat digestion and absorption_Homo sapiens_hsa049750.78576425
64African trypanosomiasis_Homo sapiens_hsa051430.76775485
65Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75997713
66Adherens junction_Homo sapiens_hsa045200.75810359
67cAMP signaling pathway_Homo sapiens_hsa040240.75302048
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.74626514
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74173412
70HIF-1 signaling pathway_Homo sapiens_hsa040660.72942726
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.72708116
72Hepatitis C_Homo sapiens_hsa051600.71766863
73Small cell lung cancer_Homo sapiens_hsa052220.71312146
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.70516383
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70302913
76Phenylalanine metabolism_Homo sapiens_hsa003600.70136903
77Malaria_Homo sapiens_hsa051440.70135877
78Neurotrophin signaling pathway_Homo sapiens_hsa047220.69702306
79Legionellosis_Homo sapiens_hsa051340.67988409
80Fructose and mannose metabolism_Homo sapiens_hsa000510.67959868
81Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67580995
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67338701
83Dorso-ventral axis formation_Homo sapiens_hsa043200.66080390
84Glucagon signaling pathway_Homo sapiens_hsa049220.64171367
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63747497
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.63630829
87Circadian rhythm_Homo sapiens_hsa047100.63367705
88MAPK signaling pathway_Homo sapiens_hsa040100.62917182
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62095637
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61739793
91VEGF signaling pathway_Homo sapiens_hsa043700.61507520
92GnRH signaling pathway_Homo sapiens_hsa049120.60622509
93Drug metabolism - other enzymes_Homo sapiens_hsa009830.60214516
94Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59511403
95Pertussis_Homo sapiens_hsa051330.59366487
96PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57897925
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57497639
98Selenocompound metabolism_Homo sapiens_hsa004500.56995356
99Proteoglycans in cancer_Homo sapiens_hsa052050.56471289
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56227558
101Estrogen signaling pathway_Homo sapiens_hsa049150.55506759
102Tyrosine metabolism_Homo sapiens_hsa003500.55061408
103Retinol metabolism_Homo sapiens_hsa008300.55041339
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55039616
105Renin secretion_Homo sapiens_hsa049240.54707961
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.53233875
107Chemical carcinogenesis_Homo sapiens_hsa052040.51595426
108Vitamin digestion and absorption_Homo sapiens_hsa049770.50450596
109AMPK signaling pathway_Homo sapiens_hsa041520.50149281
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49202171
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48994551
112Steroid hormone biosynthesis_Homo sapiens_hsa001400.48988538
113Toxoplasmosis_Homo sapiens_hsa051450.48565346
114Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48252924
115Tuberculosis_Homo sapiens_hsa051520.47347147
116Shigellosis_Homo sapiens_hsa051310.47126617
117Melanogenesis_Homo sapiens_hsa049160.46706580
118Phagosome_Homo sapiens_hsa041450.46423903
119Leishmaniasis_Homo sapiens_hsa051400.46365931
120Biosynthesis of amino acids_Homo sapiens_hsa012300.46301997
121Oocyte meiosis_Homo sapiens_hsa041140.45911681
122Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43536771
123Bladder cancer_Homo sapiens_hsa052190.42718621
124GABAergic synapse_Homo sapiens_hsa047270.41731039
125Prion diseases_Homo sapiens_hsa050200.40964101
126Mineral absorption_Homo sapiens_hsa049780.40727124
127Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40256079
128Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40141738
129Folate biosynthesis_Homo sapiens_hsa007900.39851723
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39254144
131Other glycan degradation_Homo sapiens_hsa005110.38824435
132Protein digestion and absorption_Homo sapiens_hsa049740.38722756
133Glycosaminoglycan degradation_Homo sapiens_hsa005310.37713067
134Long-term depression_Homo sapiens_hsa047300.37567738
135Morphine addiction_Homo sapiens_hsa050320.37436758
136Osteoclast differentiation_Homo sapiens_hsa043800.36387340
137Glycerolipid metabolism_Homo sapiens_hsa005610.35956925
138Pathways in cancer_Homo sapiens_hsa052000.35284266
139Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.34588934
140Insulin signaling pathway_Homo sapiens_hsa049100.32334868
141Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31053860
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30157251
143Renal cell carcinoma_Homo sapiens_hsa052110.29485503
144Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29484074

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