CCL8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of cAMP-mediated signaling (GO:0043950)6.71354988
2positive regulation of type 2 immune response (GO:0002830)6.28427449
3T cell migration (GO:0072678)5.86497026
4antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.59607323
5cellular response to ethanol (GO:0071361)5.54005892
6adhesion of symbiont to host cell (GO:0044650)5.44301399
7virion attachment to host cell (GO:0019062)5.44301399
8cellular response to type I interferon (GO:0071357)5.31409777
9type I interferon signaling pathway (GO:0060337)5.31409777
10response to type I interferon (GO:0034340)5.22892467
11positive regulation of monocyte chemotaxis (GO:0090026)5.10063048
12negative regulation of interleukin-12 production (GO:0032695)4.98468510
13monocyte chemotaxis (GO:0002548)4.85113942
14protein heterotrimerization (GO:0070208)4.71882989
15interferon-gamma-mediated signaling pathway (GO:0060333)4.66926154
16adhesion of symbiont to host (GO:0044406)4.61074455
17regulation of monocyte chemotaxis (GO:0090025)4.45134683
18lipopolysaccharide-mediated signaling pathway (GO:0031663)4.44281261
19regulation of T-helper 1 cell differentiation (GO:0045625)4.30110156
20regulation of lymphocyte chemotaxis (GO:1901623)4.28521301
21positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.24424922
22regulation of type 2 immune response (GO:0002828)4.17305546
23regulation of tolerance induction (GO:0002643)4.12297899
24positive regulation of toll-like receptor signaling pathway (GO:0034123)4.08490229
25regulation of hypersensitivity (GO:0002883)4.07609897
26T-helper 1 type immune response (GO:0042088)4.05530763
27B cell mediated immunity (GO:0019724)4.03113623
28positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.02225341
29negative regulation of viral genome replication (GO:0045071)4.00699031
30negative regulation of granulocyte differentiation (GO:0030853)3.96842315
31response to peptidoglycan (GO:0032494)3.95328053
32cellular response to interferon-gamma (GO:0071346)3.94097994
33keratan sulfate catabolic process (GO:0042340)3.93647606
34cytidine metabolic process (GO:0046087)3.91013627
35cytidine catabolic process (GO:0006216)3.91013627
36cytidine deamination (GO:0009972)3.91013627
37positive regulation of macrophage cytokine production (GO:0060907)3.90817325
38positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.87236013
39positive regulation of lymphocyte migration (GO:2000403)3.86610315
40cellular response to exogenous dsRNA (GO:0071360)3.86222303
41positive regulation of T-helper cell differentiation (GO:0045624)3.85453108
42sexual reproduction (GO:0019953)3.84491080
43response to interferon-gamma (GO:0034341)3.82382102
44apoptotic cell clearance (GO:0043277)3.79691925
45regulation of lymphocyte migration (GO:2000401)3.75211359
46regulation of cAMP-mediated signaling (GO:0043949)3.75076018
47response to interferon-beta (GO:0035456)3.68274966
48regulation of T-helper 2 cell differentiation (GO:0045628)3.66488312
49phagocytosis, engulfment (GO:0006911)3.64802567
50antigen processing and presentation of endogenous antigen (GO:0019883)3.62598426
51regulation of chronic inflammatory response (GO:0002676)3.62108911
52microglial cell activation (GO:0001774)3.60711217
53cellular extravasation (GO:0045123)3.60233869
54positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.59916204
55regulation of macrophage chemotaxis (GO:0010758)3.59203508
56macrophage activation involved in immune response (GO:0002281)3.58643664
57positive regulation by symbiont of host defense response (GO:0052509)3.56039613
58modulation by symbiont of host defense response (GO:0052031)3.56039613
59modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.56039613
60modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.56039613
61positive regulation by organism of defense response of other organism involved in symbiotic interact3.56039613
62modulation by symbiont of host immune response (GO:0052553)3.56039613
63sequestering of actin monomers (GO:0042989)3.55165300
64regulation of vitamin D biosynthetic process (GO:0060556)3.54781671
65positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.50760391
66cellular response to interferon-beta (GO:0035458)3.48818761
67positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.46547923
68neutrophil activation involved in immune response (GO:0002283)3.45831835
69pinocytosis (GO:0006907)3.44249374
70regulation of cholesterol storage (GO:0010885)3.42967514
71regulation of interferon-beta biosynthetic process (GO:0045357)3.41798529
72regulation of inflammatory response to antigenic stimulus (GO:0002861)3.37927793
73production of molecular mediator involved in inflammatory response (GO:0002532)3.37513416
74myeloid dendritic cell differentiation (GO:0043011)3.35318943
75defense response to virus (GO:0051607)3.32991942
76immunoglobulin mediated immune response (GO:0016064)3.31381841
77positive regulation of cholesterol efflux (GO:0010875)3.31297199
78regulation of dendritic cell antigen processing and presentation (GO:0002604)3.29745032
79collagen fibril organization (GO:0030199)3.28926768
80positive regulation of cellular amide metabolic process (GO:0034250)3.28365745
81cellular response to lipopolysaccharide (GO:0071222)3.27972933
82defense response to protozoan (GO:0042832)3.26594808
83lymphocyte migration (GO:0072676)3.24874486
84chemokine-mediated signaling pathway (GO:0070098)3.22546629
85cellular response to molecule of bacterial origin (GO:0071219)3.21228007
86molting cycle (GO:0042303)3.20832491
87hair cycle (GO:0042633)3.20832491
88regulation of T-helper cell differentiation (GO:0045622)3.19932432
89regulation of interleukin-12 production (GO:0032655)3.19324811
90regulation of granulocyte chemotaxis (GO:0071622)3.17392817
91regulation of mononuclear cell migration (GO:0071675)3.16196768
92granulocyte chemotaxis (GO:0071621)3.15064147
93regulation of T cell tolerance induction (GO:0002664)3.14799037
94regulation of macrophage cytokine production (GO:0010935)3.14407664
95positive regulation of interleukin-10 production (GO:0032733)3.14073671
96kynurenine metabolic process (GO:0070189)3.12755135
97regulation of interleukin-10 production (GO:0032653)3.11958721
98positive regulation of antigen processing and presentation (GO:0002579)3.11810491
99negative regulation of myeloid cell apoptotic process (GO:0033033)3.10425050
100cellular response to thyroid hormone stimulus (GO:0097067)3.07827421
101collagen metabolic process (GO:0032963)3.07769571
102positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.07709675
103response to protozoan (GO:0001562)3.07563003
104collagen catabolic process (GO:0030574)3.06859204
105regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.06838485
106complement activation, alternative pathway (GO:0006957)3.06815287
107cellular response to interferon-alpha (GO:0035457)3.05636432
108positive regulation of sterol transport (GO:0032373)3.05080412
109positive regulation of cholesterol transport (GO:0032376)3.05080412
110regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.04082243
111low-density lipoprotein particle clearance (GO:0034383)3.03264127
112negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.03170070
113complement activation (GO:0006956)3.03013425
114negative regulation of smooth muscle cell migration (GO:0014912)3.01803318
115granulocyte migration (GO:0097530)3.01258082
116positive regulation of gamma-delta T cell activation (GO:0046645)3.00085628
117positive regulation of leukocyte migration (GO:0002687)2.99136565
118positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)2.98377398
119regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.98343900
120skin morphogenesis (GO:0043589)2.98335187
121phagocytosis, recognition (GO:0006910)2.97752095
122macrophage activation (GO:0042116)2.96841097
123detection of molecule of bacterial origin (GO:0032490)2.96274258
124positive regulation of interleukin-12 production (GO:0032735)2.94813667
125multicellular organismal macromolecule metabolic process (GO:0044259)2.94198199
126dendritic cell differentiation (GO:0097028)2.93410127
127positive regulation of acute inflammatory response (GO:0002675)2.92644905
128positive regulation of interleukin-1 beta secretion (GO:0050718)2.92570001
129interferon-gamma secretion (GO:0072643)2.92367924
130regulation of type I interferon-mediated signaling pathway (GO:0060338)2.92329458
131eosinophil chemotaxis (GO:0048245)2.89861268
132mannose metabolic process (GO:0006013)2.87310787
133multicellular organismal catabolic process (GO:0044243)2.84669198
134response to lipoprotein particle (GO:0055094)2.82911723
135complement activation, classical pathway (GO:0006958)2.81392108
136negative regulation of heart growth (GO:0061117)2.81253705
137negative regulation of cardiac muscle tissue growth (GO:0055022)2.81253705
138pyrimidine ribonucleoside catabolic process (GO:0046133)2.79832876
139cortical actin cytoskeleton organization (GO:0030866)2.79817326
140positive regulation of interferon-alpha production (GO:0032727)2.78173535
141multicellular organismal metabolic process (GO:0044236)2.78010485
142Arp2/3 complex-mediated actin nucleation (GO:0034314)2.76372867
143fibril organization (GO:0097435)2.75148089
144regulation of integrin-mediated signaling pathway (GO:2001044)2.73751662
145extracellular fibril organization (GO:0043206)2.73670068
146regulation of complement activation (GO:0030449)2.72753730
147response to interferon-alpha (GO:0035455)2.71286846
148positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.71258769
149regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.70922256
150response to acidic pH (GO:0010447)2.70528427
151positive regulation of leukocyte chemotaxis (GO:0002690)2.70000143
152peptide cross-linking (GO:0018149)2.67464805
153phospholipid efflux (GO:0033700)2.65865980
154lipoprotein transport (GO:0042953)2.63155772
155positive regulation of smooth muscle cell migration (GO:0014911)2.63081531
156regulation of interferon-alpha production (GO:0032647)2.61569382
157negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.60826133
158endothelial cell chemotaxis (GO:0035767)2.60082740
159regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.59837079
160cortical cytoskeleton organization (GO:0030865)2.59653540
161regulation of antigen processing and presentation (GO:0002577)2.59472079
162lymphocyte chemotaxis (GO:0048247)2.56923931
163positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.56310691
164regulation of B cell receptor signaling pathway (GO:0050855)2.54388447
165regulation of leukocyte chemotaxis (GO:0002688)2.53959614
166membrane invagination (GO:0010324)2.53895847
167positive regulation of natural killer cell differentiation (GO:0032825)2.52682641
168basement membrane organization (GO:0071711)2.51513014
169negative regulation of protein localization to plasma membrane (GO:1903077)2.49652327
170stress fiber assembly (GO:0043149)2.48421879
171positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.47343348
172eosinophil migration (GO:0072677)2.46466464

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.62740355
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.49570367
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.04338391
4GATA1_22025678_ChIP-Seq_K562_Human3.99253650
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.72996136
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.62276548
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.29663174
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.20767886
9CLOCK_20551151_ChIP-Seq_293T_Human3.18362155
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.15373471
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.02628547
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.78255955
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.63096217
14RARG_19884340_ChIP-ChIP_MEFs_Mouse2.59522344
15Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.34294543
16THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.25680497
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.20669974
18FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.17216833
19* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.11944873
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.87351567
21CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.79952401
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.77902206
23STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.76898708
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76478644
25GATA2_21666600_ChIP-Seq_HMVEC_Human1.71627673
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66668646
27RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.65050088
28ESR1_21235772_ChIP-Seq_MCF-7_Human1.64517645
29IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.63528121
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.60904033
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56816175
32* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.56468918
33LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.52396440
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.51304801
35VDR_24787735_ChIP-Seq_THP-1_Human1.51104475
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.50131316
37SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.49525122
38EGR1_19032775_ChIP-ChIP_M12_Human1.49352892
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.48526311
40STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48316769
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.47888251
42CJUN_26792858_Chip-Seq_BT549_Human1.47189604
43STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.46854727
44VDR_24763502_ChIP-Seq_THP-1_Human1.44987634
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.41871184
46CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.41410327
47STAT1_20625510_ChIP-Seq_HELA_Human1.38486472
48LXR_22292898_ChIP-Seq_THP-1_Human1.37824429
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35913135
50SPI1_23127762_ChIP-Seq_K562_Human1.33445913
51* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32854557
52WT1_19549856_ChIP-ChIP_CCG9911_Human1.30327207
53KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29452550
54ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27848145
55MYB_26560356_Chip-Seq_TH2_Human1.27483585
56RXR_22158963_ChIP-Seq_LIVER_Mouse1.26552348
57P63_26484246_Chip-Seq_KERATINOCYTES_Human1.25125906
58SOX2_20726797_ChIP-Seq_SW620_Human1.25024636
59* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24605262
60* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.23346100
61LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22489940
62SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20057821
63TFEB_21752829_ChIP-Seq_HELA_Human1.19876423
64MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19789745
65SCL_19346495_ChIP-Seq_HPC-7_Human1.15844625
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15562044
67LXR_22158963_ChIP-Seq_LIVER_Mouse1.14992219
68MAF_26560356_Chip-Seq_TH1_Human1.13249389
69SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12489631
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.11814630
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11025500
72KDM2B_26808549_Chip-Seq_DND41_Human1.10755584
73STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10632671
74EGR1_19374776_ChIP-ChIP_THP-1_Human1.09806909
75SPI1_23547873_ChIP-Seq_NB4_Human1.09732358
76PU_27001747_Chip-Seq_BMDM_Mouse1.09707556
77ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.08440798
78CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08324163
79CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07903414
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07560710
81SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07474537
82SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07474537
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07285025
84GATA3_26560356_Chip-Seq_TH2_Human1.06922369
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06413368
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06308733
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.06083415
88PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05558877
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04638985
90SPI1_20517297_ChIP-Seq_HL60_Human1.04566923
91JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03998213
92ZFP281_18757296_ChIP-ChIP_E14_Mouse1.03570936
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.03145414
94FOXO3_23340844_ChIP-Seq_DLD1_Human1.01759702
95WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.98943845
96JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98167970
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97769975
98E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97409370
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97189079
100VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96764151
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94575440
102FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93102552
103SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93035334
104KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.92886137
105EGR1_23403033_ChIP-Seq_LIVER_Mouse0.92228021
106RUNX1_22412390_ChIP-Seq_EML_Mouse0.92202792
107VDR_21846776_ChIP-Seq_THP-1_Human0.91348057
108PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90952868
109GATA1_19941827_ChIP-Seq_MEL_Mouse0.90472218
110GATA3_27048872_Chip-Seq_THYMUS_Human0.90399679
111PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89965261
112STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89306056
113RACK7_27058665_Chip-Seq_MCF-7_Human0.88966928
114SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88903886
115TCF7_22412390_ChIP-Seq_EML_Mouse0.88775951
116HIF1A_21447827_ChIP-Seq_MCF-7_Human0.88614996
117MYB_26560356_Chip-Seq_TH1_Human0.88572433
118SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88538782
119MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.88134240
120RUNX_20019798_ChIP-Seq_JUKART_Human0.88115998
121FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.86893237
122CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.86765676
123SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86576929
124GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86015337
125FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.76649253
126GATA2_22383799_ChIP-Seq_G1ME_Mouse0.74410028
127SALL4_18804426_ChIP-ChIP_XEN_Mouse0.73491830
128BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.65081242
129SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64171654
130SMRT_27268052_Chip-Seq_Bcells_Human0.62398146
131TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.62231679
132ELF1_20517297_ChIP-Seq_JURKAT_Human0.58794844
133GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.56909420
134GATA1_19941826_ChIP-Seq_K562_Human0.54971875
135GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.54702667
136SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.53867246
137MAF_26560356_Chip-Seq_TH2_Human0.53350942
138UTX_26944678_Chip-Seq_JUKART_Human0.53053160

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.59236490
2MP0005275_abnormal_skin_tensile5.82068927
3MP0005058_abnormal_lysosome_morphology3.79235254
4MP0003191_abnormal_cellular_cholesterol3.72174219
5MP0003705_abnormal_hypodermis_morpholog3.41875685
6MP0005503_abnormal_tendon_morphology3.30868861
7MP0009840_abnormal_foam_cell2.66480899
8MP0001835_abnormal_antigen_presentation2.66222062
9MP0003436_decreased_susceptibility_to2.47586849
10MP0000343_altered_response_to2.41930964
11MP0002139_abnormal_hepatobiliary_system2.28262694
12MP0003279_aneurysm2.21239943
13MP0002254_reproductive_system_inflammat2.12626682
14MP0005167_abnormal_blood-brain_barrier2.11839092
15MP0001533_abnormal_skeleton_physiology2.09650660
16MP0002060_abnormal_skin_morphology2.08018284
17MP0002419_abnormal_innate_immunity2.03674301
18MP0002148_abnormal_hypersensitivity_rea2.00701511
19MP0003724_increased_susceptibility_to1.99403055
20MP0000604_amyloidosis1.90949504
21MP0005000_abnormal_immune_tolerance1.70230673
22MP0010368_abnormal_lymphatic_system1.69707427
23MP0001958_emphysema1.67145313
24MP0003690_abnormal_glial_cell1.66548877
25MP0003303_peritoneal_inflammation1.63282037
26MP0005025_abnormal_response_to1.63048224
27MP0009333_abnormal_splenocyte_physiolog1.61572019
28MP0000569_abnormal_digit_pigmentation1.60737058
29MP0000920_abnormal_myelination1.60647982
30MP0003183_abnormal_peptide_metabolism1.55591633
31MP0002277_abnormal_respiratory_mucosa1.54981370
32MP0003448_altered_tumor_morphology1.54339589
33MP0003566_abnormal_cell_adhesion1.53576746
34MP0001243_abnormal_dermal_layer1.53399063
35MP0003806_abnormal_nucleotide_metabolis1.50405583
36MP0002796_impaired_skin_barrier1.46403188
37MP0003075_altered_response_to1.40687386
38MP0002295_abnormal_pulmonary_circulatio1.40599916
39MP0003195_calcinosis1.35698482
40MP0004130_abnormal_muscle_cell1.35277608
41MP0003300_gastrointestinal_ulcer1.34193819
42MP0001790_abnormal_immune_system1.33922132
43MP0005387_immune_system_phenotype1.33922132
44MP0000685_abnormal_immune_system1.33094540
45MP0000716_abnormal_immune_system1.32785313
46MP0005390_skeleton_phenotype1.32043983
47MP0002933_joint_inflammation1.29157401
48MP0006054_spinal_hemorrhage1.27614151
49MP0006082_CNS_inflammation1.25679024
50MP0002452_abnormal_antigen_presenting1.24605568
51MP0005023_abnormal_wound_healing1.23710360
52MP0004185_abnormal_adipocyte_glucose1.23097598
53MP0002998_abnormal_bone_remodeling1.19807294
54MP0005451_abnormal_body_composition1.18873923
55MP0004510_myositis1.16889137
56MP0001853_heart_inflammation1.15318047
57MP0009785_altered_susceptibility_to1.14033972
58MP0009278_abnormal_bone_marrow1.11441662
59MP0001542_abnormal_bone_strength1.09245462
60MP0001800_abnormal_humoral_immune1.08354642
61MP0005666_abnormal_adipose_tissue1.06681818
62MP0004883_abnormal_blood_vessel1.05689528
63MP0005464_abnormal_platelet_physiology1.05128338
64MP0005166_decreased_susceptibility_to1.04297607
65MP0005164_abnormal_response_to1.03799455
66MP0002723_abnormal_immune_serum1.03471120
67MP0002405_respiratory_system_inflammati1.03345867
68MP0003453_abnormal_keratinocyte_physiol1.02294535
69MP0002166_altered_tumor_susceptibility1.01407161
70MP0005670_abnormal_white_adipose1.01354122
71MP0009764_decreased_sensitivity_to1.00312269
72MP0002429_abnormal_blood_cell0.98302079
73MP0002398_abnormal_bone_marrow0.96810884
74MP0001879_abnormal_lymphatic_vessel0.96676075
75MP0001845_abnormal_inflammatory_respons0.96271090
76MP0002420_abnormal_adaptive_immunity0.95752045
77MP0004947_skin_inflammation0.95241405
78MP0001819_abnormal_immune_cell0.95179273
79MP0000249_abnormal_blood_vessel0.94706481
80MP0005671_abnormal_response_to0.93787663
81MP0000371_diluted_coat_color0.93262497
82MP0008469_abnormal_protein_level0.93038740
83MP0000015_abnormal_ear_pigmentation0.92797299
84MP0000858_altered_metastatic_potential0.91947026
85MP0003828_pulmonary_edema0.90390553
86MP0003329_amyloid_beta_deposits0.88548735
87MP0009765_abnormal_xenobiotic_induced0.86690458
88MP0000647_abnormal_sebaceous_gland0.85832218
89MP0005397_hematopoietic_system_phenotyp0.84523259
90MP0001545_abnormal_hematopoietic_system0.84523259
91MP0005076_abnormal_cell_differentiation0.83909005
92MP0002332_abnormal_exercise_endurance0.83737434
93MP0001851_eye_inflammation0.82336727
94MP0010771_integument_phenotype0.80484486
95MP0008874_decreased_physiological_sensi0.80333962
96MP0008004_abnormal_stomach_pH0.80129288
97MP0000579_abnormal_nail_morphology0.79293421
98MP0005310_abnormal_salivary_gland0.79209974
99MP0005174_abnormal_tail_pigmentation0.78474657
100MP0009763_increased_sensitivity_to0.77696348
101MP0005508_abnormal_skeleton_morphology0.77134519
102MP0004782_abnormal_surfactant_physiolog0.75892590
103MP0004233_abnormal_muscle_weight0.74998256
104MP0000689_abnormal_spleen_morphology0.74551580
105MP0002090_abnormal_vision0.74309926
106MP0001663_abnormal_digestive_system0.73011642
107MP0001216_abnormal_epidermal_layer0.72587383
108MP0005365_abnormal_bile_salt0.72246635
109MP0003795_abnormal_bone_structure0.71851788
110MP0005257_abnormal_intraocular_pressure0.71747165
111MP0003172_abnormal_lysosome_physiology0.71601740
112MP0004272_abnormal_basement_membrane0.71543024
113MP0005375_adipose_tissue_phenotype0.70687638
114MP0000465_gastrointestinal_hemorrhage0.69993763
115MP0005647_abnormal_sex_gland0.69869600
116MP0010329_abnormal_lipoprotein_level0.69714126
117MP0002971_abnormal_brown_adipose0.69514717
118MP0009115_abnormal_fat_cell0.69444437
119MP0000750_abnormal_muscle_regeneration0.69315146
120MP0008875_abnormal_xenobiotic_pharmacok0.67929061
121MP0010234_abnormal_vibrissa_follicle0.67352845
122MP0002693_abnormal_pancreas_physiology0.67071585
123MP0001756_abnormal_urination0.66739500
124MP0005165_increased_susceptibility_to0.66084860
125MP0000767_abnormal_smooth_muscle0.65486180
126MP0003091_abnormal_cell_migration0.64504347
127MP0003656_abnormal_erythrocyte_physiolo0.64475103
128MP0002108_abnormal_muscle_morphology0.63924784
129MP0010155_abnormal_intestine_physiology0.63473173
130MP0001915_intracranial_hemorrhage0.63404231
131MP0002006_tumorigenesis0.63123960
132MP0000733_abnormal_muscle_development0.62632315
133MP0002722_abnormal_immune_system0.61487911
134MP0010307_abnormal_tumor_latency0.59703789
135MP0000609_abnormal_liver_physiology0.59264507
136MP0002877_abnormal_melanocyte_morpholog0.57983962
137MP0002138_abnormal_hepatobiliary_system0.57940312
138MP0008260_abnormal_autophagy0.56485004
139MP0005584_abnormal_enzyme/coenzyme_acti0.56223025
140MP0003646_muscle_fatigue0.56189661
141MP0005319_abnormal_enzyme/_coenzyme0.56165812
142MP0003186_abnormal_redox_activity0.55972181

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)8.82665306
2Glomerulonephritis (HP:0000099)6.78639538
3Complement deficiency (HP:0004431)6.69148858
4Abnormality of complement system (HP:0005339)5.78145450
5Protrusio acetabuli (HP:0003179)4.59840260
6Premature rupture of membranes (HP:0001788)4.59047541
7Thick nail (HP:0001805)4.24169000
8Optic neuritis (HP:0100653)4.22860755
9Retrobulbar optic neuritis (HP:0100654)4.22860755
10Cerebral aneurysm (HP:0004944)4.14761382
11Alopecia of scalp (HP:0002293)4.06014396
12Aortic dissection (HP:0002647)4.03068653
13Nephritis (HP:0000123)4.02892341
14Premature loss of primary teeth (HP:0006323)3.97217074
15Recurrent abscess formation (HP:0002722)3.90774026
16Dysostosis multiplex (HP:0000943)3.89079986
17Recurrent bacterial skin infections (HP:0005406)3.86224640
18Osteolytic defects of the phalanges of the hand (HP:0009771)3.83907633
19Osteolytic defects of the hand bones (HP:0009699)3.83907633
20Vacuolated lymphocytes (HP:0001922)3.73330021
21Hemoptysis (HP:0002105)3.69254614
22Prostate neoplasm (HP:0100787)3.68780050
23Recurrent cutaneous fungal infections (HP:0011370)3.61955525
24Chronic mucocutaneous candidiasis (HP:0002728)3.61955525
25Increased cerebral lipofuscin (HP:0011813)3.56680809
26Loss of speech (HP:0002371)3.47165947
27Arterial tortuosity (HP:0005116)3.43067173
28Follicular hyperkeratosis (HP:0007502)3.40220446
29Aortic aneurysm (HP:0004942)3.34774522
30Increased IgM level (HP:0003496)3.29501586
31Striae distensae (HP:0001065)3.29328492
32Stomatitis (HP:0010280)3.28830627
33Soft skin (HP:0000977)3.28158969
34Albinism (HP:0001022)3.26930082
35Pulmonary infiltrates (HP:0002113)3.25424558
36Vascular tortuosity (HP:0004948)3.24327261
37Peritonitis (HP:0002586)3.24210972
38Atrophic scars (HP:0001075)3.18001616
39Eczematoid dermatitis (HP:0000976)3.02546071
40Increased neuronal autofluorescent lipopigment (HP:0002074)3.00793010
41Mutism (HP:0002300)2.97186706
42Dilatation of the ascending aorta (HP:0005111)2.95265049
43Abnormality of the prostate (HP:0008775)2.91357755
44Recurrent fungal infections (HP:0002841)2.91271448
45Vertebral compression fractures (HP:0002953)2.85092859
46Cheilitis (HP:0100825)2.81203152
47Neoplasm of head and neck (HP:0012288)2.80193840
48Esophageal neoplasm (HP:0100751)2.80193840
49Keratoconjunctivitis sicca (HP:0001097)2.78842880
50Mitral valve prolapse (HP:0001634)2.77690867
51Bladder diverticulum (HP:0000015)2.75337463
52Hematochezia (HP:0002573)2.73580596
53Neurofibrillary tangles (HP:0002185)2.69240284
54Disinhibition (HP:0000734)2.68729563
55Spontaneous hematomas (HP:0007420)2.67013314
56Recurrent gram-negative bacterial infections (HP:0005420)2.66920851
57Vasculitis (HP:0002633)2.66474153
58Agnosia (HP:0010524)2.63581529
59Increased connective tissue (HP:0009025)2.63396889
60Blue sclerae (HP:0000592)2.63131477
61Type 1 muscle fiber predominance (HP:0003803)2.61945104
62Spondylolisthesis (HP:0003302)2.58342638
63Increased serum ferritin (HP:0003281)2.55051770
64Gingivitis (HP:0000230)2.55002108
65Keratoconjunctivitis (HP:0001096)2.52787791
66Abnormality of nail color (HP:0100643)2.49457921
67Fragile skin (HP:0001030)2.48229251
68Nuclear cataract (HP:0100018)2.44371019
69Obstructive lung disease (HP:0006536)2.44277427
70Chronic obstructive pulmonary disease (HP:0006510)2.44277427
71Round ear (HP:0100830)2.41992555
72Inappropriate behavior (HP:0000719)2.41197804
73Malnutrition (HP:0004395)2.40801974
74Myocardial infarction (HP:0001658)2.37824876
75Gangrene (HP:0100758)2.37010625
76Recurrent viral infections (HP:0004429)2.36600813
77Axonal loss (HP:0003447)2.35766467
78Cervical subluxation (HP:0003308)2.33998427
79Abnormality of the endocardium (HP:0004306)2.33361229
80Wormian bones (HP:0002645)2.30554429
81Ankle contracture (HP:0006466)2.29766894
82Mucopolysacchariduria (HP:0008155)2.28428395
83Urinary glycosaminoglycan excretion (HP:0003541)2.28428395
84Autoimmune thrombocytopenia (HP:0001973)2.26118212
85Abnormality of T cell number (HP:0011839)2.25032190
86Metaphyseal irregularity (HP:0003025)2.24703860
87T lymphocytopenia (HP:0005403)2.23971120
88Apathy (HP:0000741)2.23707525
89Nausea (HP:0002018)2.22536105
90Hypergammaglobulinemia (HP:0010702)2.20899852
91Autoimmune hemolytic anemia (HP:0001890)2.20494333
92Cerebral inclusion bodies (HP:0100314)2.18324557
93Myositis (HP:0100614)2.17054744
94Diminished motivation (HP:0000745)2.17022781
95Broad metatarsal (HP:0001783)2.14727951
96Abnormality of iron homeostasis (HP:0011031)2.13286737
97Urticaria (HP:0001025)2.13242374
98Shallow orbits (HP:0000586)2.12731901
99Meningitis (HP:0001287)2.12429610
100Amyloidosis (HP:0011034)2.11054146
101Memory impairment (HP:0002354)2.08196822
102Elevated erythrocyte sedimentation rate (HP:0003565)2.06196603
103Hyperextensible skin (HP:0000974)2.04811956
104Basal ganglia calcification (HP:0002135)2.04012142
105Abnormality of macrophages (HP:0004311)2.03635478
106Hypertensive crisis (HP:0100735)1.99512018
107Abnormality of polysaccharide metabolism (HP:0011012)1.98862895
108Abnormality of glycosaminoglycan metabolism (HP:0004371)1.98862895
109Abnormality of mucopolysaccharide metabolism (HP:0011020)1.98862895
110Palmoplantar hyperkeratosis (HP:0000972)1.97471417
111Abnormality of the pleura (HP:0002103)1.96368410
112Chronic otitis media (HP:0000389)1.96203621
113Pustule (HP:0200039)1.95929992
114Arterial thrombosis (HP:0004420)1.94193391
115Neuronal loss in central nervous system (HP:0002529)1.94117392
116Asymmetric septal hypertrophy (HP:0001670)1.94020828
117Joint stiffness (HP:0001387)1.93678868
118Recurrent bronchitis (HP:0002837)1.93211858
119Venous abnormality (HP:0002624)1.92116985
120Polyneuropathy (HP:0001271)1.90808943
121IgA deficiency (HP:0002720)1.90521179
122Abnormality of glycolipid metabolism (HP:0010969)1.89278560
123Abnormality of liposaccharide metabolism (HP:0010968)1.89278560
124Abnormality of glycosphingolipid metabolism (HP:0004343)1.89278560
125Spinal rigidity (HP:0003306)1.88701690
126Periodontitis (HP:0000704)1.88571447
127Chest pain (HP:0100749)1.88273622
128Encephalitis (HP:0002383)1.87836665
129Facial diplegia (HP:0001349)1.87236519
130Recurrent skin infections (HP:0001581)1.86639140
131Muscle fiber splitting (HP:0003555)1.86245805
132Anorexia (HP:0002039)1.85630406
133Biconcave vertebral bodies (HP:0004586)1.83531788
134Progressive neurologic deterioration (HP:0002344)1.83504315
135Abnormality of dentin (HP:0010299)1.81702131
136Venous insufficiency (HP:0005293)1.80681550
137Abnormality of the lumbar spine (HP:0100712)1.78082903
138Palmar hyperkeratosis (HP:0010765)1.77555099
139Interstitial pulmonary disease (HP:0006530)1.77347672
140Ulnar deviation of the wrist (HP:0003049)1.76750245
141Exercise-induced muscle cramps (HP:0003710)1.76001778
142Mediastinal lymphadenopathy (HP:0100721)1.72626612
143Orchitis (HP:0100796)1.70054142
144Plantar hyperkeratosis (HP:0007556)1.69930122
145Increased IgE level (HP:0003212)1.69627661
146Slender build (HP:0001533)1.69146679
147Genu recurvatum (HP:0002816)1.68337235
148Aneurysm (HP:0002617)1.66632089
149Cellulitis (HP:0100658)1.64581941
150Abnormality of the vasculature of the conjunctiva (HP:0008054)1.63663562
151Purpura (HP:0000979)1.62980498
152Conjunctival telangiectasia (HP:0000524)1.60799766
153Gastrointestinal infarctions (HP:0005244)1.60767427
154Right ventricular cardiomyopathy (HP:0011663)1.60592202
155Xanthomatosis (HP:0000991)1.60525727
156Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.60087112
157Hypotrichosis (HP:0001006)1.58968690

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK6.41783794
2TGFBR24.38780349
3IRAK34.25428697
4TRIB33.85761350
5TYK23.60472260
6ERN12.89001872
7GRK72.43120602
8NME22.27608441
9SCYL22.15463848
10CAMK1D2.12437553
11TTN2.10185452
12EPHB12.02035499
13TBK11.93177419
14BMPR21.87173860
15FGFR41.84259112
16RIPK11.75515587
17LIMK11.75224597
18KIT1.73733049
19PIK3CG1.70295963
20TXK1.70105140
21TAOK21.68285648
22CAMK1G1.58557870
23EPHA31.55431181
24TESK11.55043698
25JAK11.54420161
26FGFR31.53369722
27EPHB21.44281585
28CAMKK21.41778468
29FGR1.39878775
30CSK1.38895194
31PKN21.37224870
32ERBB31.34229700
33PTK61.33485696
34KDR1.29747752
35CAMKK11.17749276
36DDR21.15694083
37JAK31.11202936
38LRRK21.09523790
39NEK91.08744095
40MATK1.07663155
41ZAP701.02459556
42MOS1.01695348
43CDC42BPA1.00788269
44PDGFRA1.00153699
45MAP3K110.98386535
46PAK40.97303421
47MAP3K30.96834141
48JAK20.96133654
49MAP3K100.94268012
50TGFBR10.90284403
51TAOK10.89386336
52CHUK0.89328228
53CSF1R0.88990214
54MAP4K10.88822930
55IRAK40.88328337
56CDK60.87423558
57ACVR1B0.86029347
58TAOK30.85627363
59PTK2B0.85465313
60HCK0.85052638
61PRPF4B0.84467320
62ILK0.82634701
63NTRK10.81227258
64BMX0.80380816
65IKBKE0.78428207
66IRAK10.76820254
67PDK20.75966331
68FES0.75197974
69FER0.74942893
70RIPK40.73869687
71ITK0.72692124
72FGFR10.71990417
73DYRK1B0.71915782
74MAP3K140.71704972
75ABL20.71187989
76MST40.70653498
77RPS6KA40.70405327
78DMPK0.69111726
79PAK20.67291872
80TRPM70.65970312
81MET0.65242240
82MAP2K30.64976423
83STK100.64455296
84EGFR0.64100456
85KSR10.62289033
86LYN0.62073386
87ADRBK20.61393898
88RET0.58389430
89DAPK20.57339017
90MAPK110.55411898
91MAPKAPK20.54324567
92MAP3K130.53861418
93MAP2K10.53656695
94PRKCD0.53603970
95MAPKAPK50.53012134
96LCK0.51572200
97MYLK0.50995629
98MAP3K50.50216527
99FYN0.49870516
100INSR0.49371264
101BTK0.49310015
102HIPK20.49226210
103MAPKAPK30.46979090
104IGF1R0.45928022
105PLK20.42594908
106PRKD10.42369364
107MAP3K20.42033724
108SYK0.41342383
109IRAK20.41145757
110PBK0.40465385
111TESK20.39909765
112TYRO30.39450507
113GSK3A0.39425992
114EIF2AK20.39311650
115MAP3K60.38749093
116ABL10.38215734
117ROCK20.37945790
118BCKDK0.36748404
119FRK0.36640102
120LATS20.35882911
121IKBKB0.35423242
122PIM20.34851508
123MAP3K10.34762931
124PHKG10.33788021
125PHKG20.33788021
126PDGFRB0.33768944
127PAK60.33523614
128PTK20.33352282
129MAP3K40.33128310
130TAF10.27653897
131MAPK40.27317248
132RPS6KA50.27009542
133MAP2K60.26860396
134PKN10.25868956
135RPS6KL10.25068889
136RPS6KC10.25068889
137MKNK10.24788690
138RPS6KA60.21048964
139PRKCQ0.20655581
140PIM10.19842237
141MARK30.19544869
142RPS6KA20.18291672
143PRKG20.14781723
144TNK20.10791754
145CLK10.10588157
146PDPK10.08870124

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051505.87876622
2Allograft rejection_Homo sapiens_hsa053304.06668704
3Asthma_Homo sapiens_hsa053103.98666429
4Autoimmune thyroid disease_Homo sapiens_hsa053203.56857528
5Graft-versus-host disease_Homo sapiens_hsa053323.53561330
6Lysosome_Homo sapiens_hsa041423.12387610
7Type I diabetes mellitus_Homo sapiens_hsa049403.06785891
8Complement and coagulation cascades_Homo sapiens_hsa046102.82857879
9Pertussis_Homo sapiens_hsa051332.63260073
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.58567531
11Prion diseases_Homo sapiens_hsa050202.46048001
12Other glycan degradation_Homo sapiens_hsa005112.45857723
13Osteoclast differentiation_Homo sapiens_hsa043802.07844206
14Phagosome_Homo sapiens_hsa041452.07466041
15Malaria_Homo sapiens_hsa051442.03159200
16Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.93766634
17Leishmaniasis_Homo sapiens_hsa051401.89633163
18Tuberculosis_Homo sapiens_hsa051521.78321167
19Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.74237856
20Antigen processing and presentation_Homo sapiens_hsa046121.62734718
21Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.59649815
22Caffeine metabolism_Homo sapiens_hsa002321.49827933
23Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.46131705
24Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44577515
25Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.39442358
26Salmonella infection_Homo sapiens_hsa051321.35704311
27PPAR signaling pathway_Homo sapiens_hsa033201.30227326
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.28678494
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.28603427
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.27937350
31Toxoplasmosis_Homo sapiens_hsa051451.26447275
32Hematopoietic cell lineage_Homo sapiens_hsa046401.25926899
33Shigellosis_Homo sapiens_hsa051311.22217793
34Amoebiasis_Homo sapiens_hsa051461.21429333
35* Chemokine signaling pathway_Homo sapiens_hsa040621.20827490
36Nitrogen metabolism_Homo sapiens_hsa009101.19040544
37Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.17735280
38Legionellosis_Homo sapiens_hsa051341.16618661
39Endocytosis_Homo sapiens_hsa041441.16457908
40Platelet activation_Homo sapiens_hsa046111.13848891
41B cell receptor signaling pathway_Homo sapiens_hsa046621.13341167
42Focal adhesion_Homo sapiens_hsa045101.11673067
43ECM-receptor interaction_Homo sapiens_hsa045121.07864177
44Rheumatoid arthritis_Homo sapiens_hsa053231.06268785
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02257009
46Proteoglycans in cancer_Homo sapiens_hsa052050.99145347
47Apoptosis_Homo sapiens_hsa042100.92133345
48Adherens junction_Homo sapiens_hsa045200.91560564
49Measles_Homo sapiens_hsa051620.87713729
50* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85904341
51Pancreatic cancer_Homo sapiens_hsa052120.85503595
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80976496
53Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79540159
54Viral myocarditis_Homo sapiens_hsa054160.79038073
55Collecting duct acid secretion_Homo sapiens_hsa049660.77193577
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.73725411
57Sphingolipid metabolism_Homo sapiens_hsa006000.73507144
58Arachidonic acid metabolism_Homo sapiens_hsa005900.68773615
59TNF signaling pathway_Homo sapiens_hsa046680.68266568
60Influenza A_Homo sapiens_hsa051640.67903766
61Renin-angiotensin system_Homo sapiens_hsa046140.66482194
62Chronic myeloid leukemia_Homo sapiens_hsa052200.66376450
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.65621875
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.64757046
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.64538757
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62261620
67HIF-1 signaling pathway_Homo sapiens_hsa040660.62028132
68VEGF signaling pathway_Homo sapiens_hsa043700.59671819
69Primary immunodeficiency_Homo sapiens_hsa053400.59286944
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.59286030
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58152971
72Epstein-Barr virus infection_Homo sapiens_hsa051690.56795674
73Protein digestion and absorption_Homo sapiens_hsa049740.56124100
74Renal cell carcinoma_Homo sapiens_hsa052110.54521083
75Mineral absorption_Homo sapiens_hsa049780.52838129
76Hepatitis C_Homo sapiens_hsa051600.51179835
77Dilated cardiomyopathy_Homo sapiens_hsa054140.50717262
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.49258452
79Hepatitis B_Homo sapiens_hsa051610.48098204
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.47989371
81Insulin resistance_Homo sapiens_hsa049310.46471050
82African trypanosomiasis_Homo sapiens_hsa051430.45765003
83Oxytocin signaling pathway_Homo sapiens_hsa049210.45671664
84Tryptophan metabolism_Homo sapiens_hsa003800.44186298
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.43773965
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43461230
87Neurotrophin signaling pathway_Homo sapiens_hsa047220.43073207
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42753684
89Ether lipid metabolism_Homo sapiens_hsa005650.40861914
90Pentose and glucuronate interconversions_Homo sapiens_hsa000400.40550548
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.39078678
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38471970
93Renin secretion_Homo sapiens_hsa049240.37539645
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.36738115
95Acute myeloid leukemia_Homo sapiens_hsa052210.34946830
96Sulfur metabolism_Homo sapiens_hsa009200.34617642
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.34564891
98Rap1 signaling pathway_Homo sapiens_hsa040150.32886165
99RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32786457
100Vibrio cholerae infection_Homo sapiens_hsa051100.32315383
101Ras signaling pathway_Homo sapiens_hsa040140.31756812
102Fatty acid metabolism_Homo sapiens_hsa012120.31445621
103Systemic lupus erythematosus_Homo sapiens_hsa053220.31313697
104T cell receptor signaling pathway_Homo sapiens_hsa046600.31188191
105GnRH signaling pathway_Homo sapiens_hsa049120.30630328
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.30343583
107Herpes simplex infection_Homo sapiens_hsa051680.29739776
108Notch signaling pathway_Homo sapiens_hsa043300.29182663
109NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29115755
110Prolactin signaling pathway_Homo sapiens_hsa049170.29084424
111HTLV-I infection_Homo sapiens_hsa051660.29006303
112Bladder cancer_Homo sapiens_hsa052190.28986676
113Fatty acid degradation_Homo sapiens_hsa000710.28329258
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.27773344
115TGF-beta signaling pathway_Homo sapiens_hsa043500.27736588
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27714330
117Fat digestion and absorption_Homo sapiens_hsa049750.27356828
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26954790
119Estrogen signaling pathway_Homo sapiens_hsa049150.26587132
120Gap junction_Homo sapiens_hsa045400.25054174
121ABC transporters_Homo sapiens_hsa020100.23955353
122Glioma_Homo sapiens_hsa052140.22928007
123Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.19721798
124Synaptic vesicle cycle_Homo sapiens_hsa047210.16815541
125Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.15366449
126Galactose metabolism_Homo sapiens_hsa000520.13066401
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.12738406
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10762508
129Type II diabetes mellitus_Homo sapiens_hsa049300.02399330
130Glutathione metabolism_Homo sapiens_hsa004800.01221385
131Viral carcinogenesis_Homo sapiens_hsa052030.00066059
132Fatty acid biosynthesis_Homo sapiens_hsa00061-0.0766996
133Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.0723268
134Drug metabolism - other enzymes_Homo sapiens_hsa00983-0.0196842

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