CCL28

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)7.01028503
2drug transmembrane transport (GO:0006855)6.27299843
3urate metabolic process (GO:0046415)5.75977473
4drug transport (GO:0015893)5.33334599
5L-fucose catabolic process (GO:0042355)5.13438337
6fucose catabolic process (GO:0019317)5.13438337
7L-fucose metabolic process (GO:0042354)5.13438337
8organic cation transport (GO:0015695)4.99771162
9detection of bacterium (GO:0016045)4.98964085
10detection of other organism (GO:0098543)4.72663746
11phosphate ion transport (GO:0006817)4.49641707
12sulfate transmembrane transport (GO:1902358)4.45339332
13oligosaccharide catabolic process (GO:0009313)4.35582428
14endocrine hormone secretion (GO:0060986)4.28280455
15sulfate transport (GO:0008272)4.18698143
16behavioral response to nicotine (GO:0035095)4.04311237
17phosphate ion homeostasis (GO:0055062)3.99726711
18trivalent inorganic anion homeostasis (GO:0072506)3.99726711
19excretion (GO:0007588)3.97737325
20lysine metabolic process (GO:0006553)3.97046913
21lysine catabolic process (GO:0006554)3.97046913
22toxin transport (GO:1901998)3.93132846
23polyol transport (GO:0015791)3.87369910
24epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.85542720
25phosphate ion transmembrane transport (GO:0035435)3.83444544
26glycoside metabolic process (GO:0016137)3.81626359
27indolalkylamine metabolic process (GO:0006586)3.78047042
28transepithelial transport (GO:0070633)3.77802211
29pyrimidine-containing compound transmembrane transport (GO:0072531)3.70296249
30axoneme assembly (GO:0035082)3.66619257
31sulfur compound transport (GO:0072348)3.66600557
32DNA deamination (GO:0045006)3.64058979
33exogenous drug catabolic process (GO:0042738)3.61222188
34nonribosomal peptide biosynthetic process (GO:0019184)3.60863677
35response to phenylpropanoid (GO:0080184)3.59055478
36O-glycan processing (GO:0016266)3.58981678
37detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.53022817
38epithelial cilium movement (GO:0003351)3.52741441
39drug catabolic process (GO:0042737)3.52146013
40receptor guanylyl cyclase signaling pathway (GO:0007168)3.50256301
41polyketide metabolic process (GO:0030638)3.47198471
42doxorubicin metabolic process (GO:0044598)3.47198471
43daunorubicin metabolic process (GO:0044597)3.47198471
44positive regulation of prostaglandin secretion (GO:0032308)3.45625188
453-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.45589527
46purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.45589527
47negative regulation of keratinocyte proliferation (GO:0010839)3.43490213
48detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.43380261
49quaternary ammonium group transport (GO:0015697)3.43167558
50renal absorption (GO:0070293)3.42557390
51short-chain fatty acid metabolic process (GO:0046459)3.38053173
52oligosaccharide biosynthetic process (GO:0009312)3.37289661
53membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.36923957
54peptide catabolic process (GO:0043171)3.34502947
55sulfation (GO:0051923)3.32743974
56cilium or flagellum-dependent cell motility (GO:0001539)3.32408680
57regulation of memory T cell differentiation (GO:0043380)3.30078269
58glutathione biosynthetic process (GO:0006750)3.29270319
59piRNA metabolic process (GO:0034587)3.27382475
60cellular ketone body metabolic process (GO:0046950)3.24661787
61detection of light stimulus involved in visual perception (GO:0050908)3.23675686
62detection of light stimulus involved in sensory perception (GO:0050962)3.23675686
63cysteine metabolic process (GO:0006534)3.22573347
64kynurenine metabolic process (GO:0070189)3.22083813
65bicarbonate transport (GO:0015701)3.20832859
66thyroid hormone metabolic process (GO:0042403)3.20749078
67metanephric tubule development (GO:0072170)3.19961712
68metanephric nephron tubule development (GO:0072234)3.19961712
69neural tube formation (GO:0001841)3.18639291
70respiratory chain complex IV assembly (GO:0008535)3.18190295
71surfactant homeostasis (GO:0043129)3.16782573
72cilium movement (GO:0003341)3.14725376
73peptide biosynthetic process (GO:0043043)3.14182308
74detection of external biotic stimulus (GO:0098581)3.13863669
75cellular response to vitamin D (GO:0071305)3.12676796
76positive regulation of fatty acid transport (GO:2000193)3.11668128
77intestinal absorption (GO:0050892)3.11480642
78thyroid hormone generation (GO:0006590)3.11052272
79positive regulation of digestive system process (GO:0060456)3.10934999
80vitamin transmembrane transport (GO:0035461)3.08982237
81nucleotide transmembrane transport (GO:1901679)3.08367426
82fucosylation (GO:0036065)3.08182353
83preassembly of GPI anchor in ER membrane (GO:0016254)3.07955039
84platelet dense granule organization (GO:0060155)3.07088775
85vitamin D metabolic process (GO:0042359)3.06620059
86water-soluble vitamin biosynthetic process (GO:0042364)3.04974895
87calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.03741369
88membrane repolarization during action potential (GO:0086011)3.02665410
89regulation of apoptotic process involved in morphogenesis (GO:1902337)3.02406821
90photoreceptor cell maintenance (GO:0045494)3.00906068
91positive regulation of icosanoid secretion (GO:0032305)2.98433689
92chemical homeostasis within a tissue (GO:0048875)2.95064752
93indolalkylamine catabolic process (GO:0046218)2.92533467
94tryptophan catabolic process (GO:0006569)2.92533467
95indole-containing compound catabolic process (GO:0042436)2.92533467
96positive regulation of defense response to virus by host (GO:0002230)2.90704508
97regulation of pH (GO:0006885)2.89100702
98positive regulation of respiratory burst (GO:0060267)2.88161251
99branched-chain amino acid metabolic process (GO:0009081)2.84931308
100mannosylation (GO:0097502)2.84436171
101UDP-N-acetylglucosamine metabolic process (GO:0006047)2.83531965
102cGMP biosynthetic process (GO:0006182)2.83107783
103maintenance of gastrointestinal epithelium (GO:0030277)2.82530789
104benzene-containing compound metabolic process (GO:0042537)2.82210173
105nephron tubule development (GO:0072080)2.82013762
106fucose metabolic process (GO:0006004)2.81470348
107nephron tubule formation (GO:0072079)2.80968591
108auditory receptor cell stereocilium organization (GO:0060088)2.79751749
109metanephric nephron epithelium development (GO:0072243)2.79474915
110cytochrome complex assembly (GO:0017004)2.78734873
111phosphatidylinositol acyl-chain remodeling (GO:0036149)2.76198573
112cornea development in camera-type eye (GO:0061303)2.75717144
113tryptophan metabolic process (GO:0006568)2.75681169
114amino-acid betaine transport (GO:0015838)2.74944995
115carnitine transport (GO:0015879)2.74944995
116DNA methylation involved in gamete generation (GO:0043046)2.72960966
117histamine transport (GO:0051608)2.72818019
118homocysteine metabolic process (GO:0050667)2.71436874
119superoxide anion generation (GO:0042554)2.70419619
120nephron tubule morphogenesis (GO:0072078)2.69591531
121nephron epithelium morphogenesis (GO:0072088)2.69591531
122peptide hormone processing (GO:0016486)2.69410017
123indole-containing compound metabolic process (GO:0042430)2.69250475
124ketone body metabolic process (GO:1902224)2.68786614
125modified amino acid transport (GO:0072337)2.65992547
126NAD biosynthetic process (GO:0009435)2.65693615
127flavonoid metabolic process (GO:0009812)2.65288404
128kidney morphogenesis (GO:0060993)2.64665140
129multicellular organism reproduction (GO:0032504)2.63797635
130cellular biogenic amine catabolic process (GO:0042402)2.63567984
131amine catabolic process (GO:0009310)2.63567984
132regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.63387089
133protein complex biogenesis (GO:0070271)2.62890438
134vitamin transport (GO:0051180)2.62628976
135biotin metabolic process (GO:0006768)2.61999784
136response to pheromone (GO:0019236)2.61867525
137GPI anchor metabolic process (GO:0006505)2.61727471
138regulation of rhodopsin mediated signaling pathway (GO:0022400)2.60820167
139axonemal dynein complex assembly (GO:0070286)2.60525233
140renal tubule development (GO:0061326)2.60459598
141cellular anion homeostasis (GO:0030002)2.60016382
142protein localization to cilium (GO:0061512)2.59017116
143rhodopsin mediated signaling pathway (GO:0016056)2.56606811
144regulation of male gonad development (GO:2000018)2.56432200
145iron ion import (GO:0097286)2.56057894
146metanephric epithelium development (GO:0072207)2.54830512
147digestive system process (GO:0022600)2.54677584
148bundle of His cell to Purkinje myocyte communication (GO:0086069)2.54043212
149oxidative demethylation (GO:0070989)2.53587273
150reflex (GO:0060004)2.53455540
151polyol catabolic process (GO:0046174)2.53364517
152endocrine pancreas development (GO:0031018)2.52539901
153regulation of cilium movement (GO:0003352)2.49207214
154regulation of prostaglandin secretion (GO:0032306)2.48889550
155L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.44399751
156signal peptide processing (GO:0006465)2.44039722
157behavioral response to ethanol (GO:0048149)2.43461949
158cilium morphogenesis (GO:0060271)2.43427107
159phosphatidylserine acyl-chain remodeling (GO:0036150)2.42986716
160protein K11-linked deubiquitination (GO:0035871)2.42205982
161auditory receptor cell differentiation (GO:0042491)2.39892376
162cellular response to ATP (GO:0071318)2.37359567
163mitochondrial respiratory chain complex assembly (GO:0033108)2.37275983
164protein-cofactor linkage (GO:0018065)2.36206217
165cilium organization (GO:0044782)2.35179203
166GPI anchor biosynthetic process (GO:0006506)2.35118271
167embryonic epithelial tube formation (GO:0001838)2.34476687
168mitochondrial respiratory chain complex I assembly (GO:0032981)2.33838163
169NADH dehydrogenase complex assembly (GO:0010257)2.33838163
170mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.33838163
171cytidine deamination (GO:0009972)2.32873586
172cytidine metabolic process (GO:0046087)2.32873586
173cytidine catabolic process (GO:0006216)2.32873586
174regulation of hexokinase activity (GO:1903299)2.32560117
175regulation of glucokinase activity (GO:0033131)2.32560117
176reciprocal DNA recombination (GO:0035825)2.32070686
177reciprocal meiotic recombination (GO:0007131)2.32070686
178arginine catabolic process (GO:0006527)2.31205020

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela3.62676249
2GBX2_23144817_ChIP-Seq_PC3_Human3.01994185
3CDX2_19796622_ChIP-Seq_MESCs_Mouse2.71429911
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.63223677
5STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.35825326
6IRF8_22096565_ChIP-ChIP_GC-B_Human2.16749252
7IGF1R_20145208_ChIP-Seq_DFB_Human2.16242979
8CDX2_20551321_ChIP-Seq_CACO-2_Human2.10805040
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.07203894
10PIAS1_25552417_ChIP-Seq_VCAP_Human2.06518111
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.04443136
12ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99592624
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85993797
14PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85089248
15POU3F2_20337985_ChIP-ChIP_501MEL_Human1.84132647
16PCGF2_27294783_Chip-Seq_NPCs_Mouse1.83738364
17EGR1_23403033_ChIP-Seq_LIVER_Mouse1.71869960
18TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.71151309
19SUZ12_18555785_Chip-Seq_ESCs_Mouse1.67028924
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66475756
21BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65745504
22TRIM28_21343339_ChIP-Seq_HEK293_Human1.64426980
23STAT3_18555785_Chip-Seq_ESCs_Mouse1.64247836
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62665049
25E2F1_18555785_Chip-Seq_ESCs_Mouse1.62332394
26P53_22387025_ChIP-Seq_ESCs_Mouse1.61813607
27EWS_26573619_Chip-Seq_HEK293_Human1.61772706
28SOX2_20726797_ChIP-Seq_SW620_Human1.60207056
29NANOG_18555785_Chip-Seq_ESCs_Mouse1.59991632
30SOX2_18555785_Chip-Seq_ESCs_Mouse1.59777142
31IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.59776266
32CBP_20019798_ChIP-Seq_JUKART_Human1.59776266
33OCT4_18555785_Chip-Seq_ESCs_Mouse1.59172650
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.57963834
35EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.57862044
36* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.57553217
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57442800
38CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.57428612
39CMYC_18555785_Chip-Seq_ESCs_Mouse1.55939727
40SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53356995
41SOX2_27498859_Chip-Seq_STOMACH_Mouse1.51199171
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.49839166
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48907035
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.48705818
45P300_19829295_ChIP-Seq_ESCs_Human1.48189378
46FOXA1_25329375_ChIP-Seq_VCAP_Human1.47050701
47FOXA1_27270436_Chip-Seq_PROSTATE_Human1.47050701
48P300_18555785_Chip-Seq_ESCs_Mouse1.46654977
49NMYC_18555785_Chip-Seq_ESCs_Mouse1.46102984
50FOXA1_21572438_ChIP-Seq_LNCaP_Human1.45447949
51SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44036511
52RUNX1_27457419_Chip-Seq_LIVER_Mouse1.43324290
53RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42926881
54EZH2_22144423_ChIP-Seq_EOC_Human1.41770435
55FOXM1_26456572_ChIP-Seq_MCF-7_Human1.41592175
56VDR_22108803_ChIP-Seq_LS180_Human1.41405858
57* GATA4_25053715_ChIP-Seq_YYC3_Human1.40933974
58ESRRB_18555785_Chip-Seq_ESCs_Mouse1.40494908
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40359534
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.40126005
61SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.39937129
62ZFX_18555785_Chip-Seq_ESCs_Mouse1.39315422
63SMAD4_21799915_ChIP-Seq_A2780_Human1.39246434
64* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38745528
65KLF4_18555785_Chip-Seq_ESCs_Mouse1.38637984
66* STAT3_23295773_ChIP-Seq_U87_Human1.38424003
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38333116
68NANOG_19829295_ChIP-Seq_ESCs_Human1.36384380
69SOX2_19829295_ChIP-Seq_ESCs_Human1.36384380
70CTCF_18555785_Chip-Seq_ESCs_Mouse1.35898024
71SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.35783874
72TP53_22573176_ChIP-Seq_HFKS_Human1.34323591
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34269974
74EZH2_27294783_Chip-Seq_NPCs_Mouse1.34171780
75SMAD1_18555785_Chip-Seq_ESCs_Mouse1.33777568
76EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.33757781
77AR_20517297_ChIP-Seq_VCAP_Human1.32757051
78GATA3_21878914_ChIP-Seq_MCF-7_Human1.32613262
79TCF4_23295773_ChIP-Seq_U87_Human1.31048830
80HOXB7_26014856_ChIP-Seq_BT474_Human1.30715895
81CDX2_22108803_ChIP-Seq_LS180_Human1.29667235
82PU1_27457419_Chip-Seq_LIVER_Mouse1.28446327
83SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28403533
84* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26838779
85TAL1_26923725_Chip-Seq_HPCs_Mouse1.26679549
86SALL1_21062744_ChIP-ChIP_HESCs_Human1.26428458
87AR_25329375_ChIP-Seq_VCAP_Human1.26273984
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26219700
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.24916802
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23817521
91AHR_22903824_ChIP-Seq_MCF-7_Human1.22120306
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20023863
93NCOR_22424771_ChIP-Seq_293T_Human1.19842883
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19789483
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.19115174
96ETV2_25802403_ChIP-Seq_MESCs_Mouse1.19096210
97ER_23166858_ChIP-Seq_MCF-7_Human1.18280856
98BCAT_22108803_ChIP-Seq_LS180_Human1.17263517
99IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.16648992
100RXR_22108803_ChIP-Seq_LS180_Human1.16502512
101CTBP2_25329375_ChIP-Seq_LNCAP_Human1.16184065
102EED_16625203_ChIP-ChIP_MESCs_Mouse1.15560987
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.15230821
104NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14503365
105NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14503365
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14332155
107NOTCH1_21737748_ChIP-Seq_TLL_Human1.13806867
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13778134
109TCF4_22108803_ChIP-Seq_LS180_Human1.13546574
110* PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13375821
111PRDM14_20953172_ChIP-Seq_ESCs_Human1.13348113
112SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13173142
113FUS_26573619_Chip-Seq_HEK293_Human1.12230435
114SMAD3_21741376_ChIP-Seq_HESCs_Human1.12177254
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11860959
116RNF2_27304074_Chip-Seq_NSC_Mouse1.11501008
117NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11324684
118CRX_20693478_ChIP-Seq_RETINA_Mouse1.11248416
119AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11234581
120GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human1.11234067
121TP63_17297297_ChIP-ChIP_HaCaT_Human1.10863129
122CBX2_27304074_Chip-Seq_ESCs_Mouse1.10768940
123TAF15_26573619_Chip-Seq_HEK293_Human1.10248658
124SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.09572038
125* TP53_18474530_ChIP-ChIP_U2OS_Human1.08502375
126Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07924947
127RUNX2_22187159_ChIP-Seq_PCA_Human1.07644640
128LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.07387798
129TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07191336
130MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07154108
131BP1_19119308_ChIP-ChIP_Hs578T_Human1.06884770
132CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.06774084
133CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06464871
134AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.06337874
135CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.06183704
136KDM2B_26808549_Chip-Seq_REH_Human1.06121734
137GATA3_26560356_Chip-Seq_TH2_Human1.05860534
138BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05796066
139GABP_17652178_ChIP-ChIP_JURKAT_Human1.04794219
140* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04486391
141AR_21572438_ChIP-Seq_LNCaP_Human1.03089714
142SMAD4_21741376_ChIP-Seq_EPCs_Human1.02392386
143TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.02368766
144FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.98797259
145FLI1_21867929_ChIP-Seq_TH2_Mouse0.98500396

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation4.79827971
2MP0002876_abnormal_thyroid_physiology4.60954397
3MP0005360_urolithiasis4.56436624
4MP0004019_abnormal_vitamin_homeostasis4.10875911
5MP0003878_abnormal_ear_physiology3.50711520
6MP0005377_hearing/vestibular/ear_phenot3.50711520
7MP0001765_abnormal_ion_homeostasis2.98276752
8MP0002139_abnormal_hepatobiliary_system2.82439873
9MP0003283_abnormal_digestive_organ2.82428108
10MP0003315_abnormal_perineum_morphology2.78135461
11MP0004264_abnormal_extraembryonic_tissu2.63589053
12MP0002009_preneoplasia2.56346437
13MP0002138_abnormal_hepatobiliary_system2.47712501
14MP0008872_abnormal_physiological_respon2.41706237
15MP0002822_catalepsy2.35848408
16MP0005636_abnormal_mineral_homeostasis2.35065345
17MP0001881_abnormal_mammary_gland2.31116306
18MP0005332_abnormal_amino_acid2.30164885
19MP0009643_abnormal_urine_homeostasis2.29608529
20MP0008875_abnormal_xenobiotic_pharmacok2.19583730
21MP0000372_irregular_coat_pigmentation2.16113497
22MP0010234_abnormal_vibrissa_follicle2.15496151
23MP0003300_gastrointestinal_ulcer2.12259863
24MP0005551_abnormal_eye_electrophysiolog2.10477896
25MP0010386_abnormal_urinary_bladder2.06523261
26MP0001873_stomach_inflammation2.05028693
27MP0000427_abnormal_hair_cycle2.03458878
28MP0005174_abnormal_tail_pigmentation1.96040341
29MP0005085_abnormal_gallbladder_physiolo1.95990120
30MP0001666_abnormal_nutrient_absorption1.94735675
31MP0001664_abnormal_digestion1.94150102
32MP0000462_abnormal_digestive_system1.92399586
33MP0005075_abnormal_melanosome_morpholog1.87934351
34MP0008877_abnormal_DNA_methylation1.87259765
35MP0001501_abnormal_sleep_pattern1.83747744
36MP0000538_abnormal_urinary_bladder1.83637926
37MP0002102_abnormal_ear_morphology1.76382159
38MP0001756_abnormal_urination1.71254113
39MP0003195_calcinosis1.71080220
40MP0001485_abnormal_pinna_reflex1.70062131
41MP0004147_increased_porphyrin_level1.65280105
42MP0009780_abnormal_chondrocyte_physiolo1.61095356
43MP0002136_abnormal_kidney_physiology1.61075612
44MP0005379_endocrine/exocrine_gland_phen1.60854783
45MP0002095_abnormal_skin_pigmentation1.58219065
46MP0000681_abnormal_thyroid_gland1.57815685
47MP0000383_abnormal_hair_follicle1.57455343
48MP0002163_abnormal_gland_morphology1.57380866
49MP0001188_hyperpigmentation1.56079277
50MP0005187_abnormal_penis_morphology1.55969140
51MP0008004_abnormal_stomach_pH1.51536976
52MP0005171_absent_coat_pigmentation1.50672897
53MP0001663_abnormal_digestive_system1.47215595
54MP0002277_abnormal_respiratory_mucosa1.43218765
55MP0005381_digestive/alimentary_phenotyp1.41763574
56MP0002837_dystrophic_cardiac_calcinosis1.41179743
57MP0003646_muscle_fatigue1.40477701
58MP0000678_abnormal_parathyroid_gland1.39836258
59MP0002938_white_spotting1.39326861
60MP0000015_abnormal_ear_pigmentation1.37656354
61MP0001346_abnormal_lacrimal_gland1.36614439
62MP0005646_abnormal_pituitary_gland1.35465531
63MP0006072_abnormal_retinal_apoptosis1.33873132
64MP0005167_abnormal_blood-brain_barrier1.33219087
65MP0005310_abnormal_salivary_gland1.30152248
66MP0002896_abnormal_bone_mineralization1.28213774
67MP0010678_abnormal_skin_adnexa1.26302016
68MP0000631_abnormal_neuroendocrine_gland1.24145056
69MP0002653_abnormal_ependyma_morphology1.23347620
70MP0004742_abnormal_vestibular_system1.23107381
71MP0004381_abnormal_hair_follicle1.22971654
72MP0004142_abnormal_muscle_tone1.22614596
73MP0001502_abnormal_circadian_rhythm1.20960977
74MP0003136_yellow_coat_color1.20690633
75MP0005253_abnormal_eye_physiology1.19769907
76MP0001968_abnormal_touch/_nociception1.17753665
77MP0003252_abnormal_bile_duct1.15438606
78MP0005645_abnormal_hypothalamus_physiol1.14821736
79MP0000569_abnormal_digit_pigmentation1.14537469
80MP0010329_abnormal_lipoprotein_level1.12564412
81MP0001986_abnormal_taste_sensitivity1.08936972
82MP0003866_abnormal_defecation1.08830569
83MP0005389_reproductive_system_phenotype1.08257541
84MP0003879_abnormal_hair_cell1.05124771
85MP0001919_abnormal_reproductive_system1.04914106
86MP0003045_fibrosis1.02110762
87MP0005410_abnormal_fertilization1.02064563
88MP0002098_abnormal_vibrissa_morphology1.01641279
89MP0005408_hypopigmentation1.00477165
90MP0003718_maternal_effect1.00372653
91MP0000613_abnormal_salivary_gland0.96340401
92MP0002638_abnormal_pupillary_reflex0.95110616
93MP0002148_abnormal_hypersensitivity_rea0.94620857
94MP0009745_abnormal_behavioral_response0.92962978
95MP0005671_abnormal_response_to0.92934870
96MP0001790_abnormal_immune_system0.92770938
97MP0005387_immune_system_phenotype0.92770938
98MP0004133_heterotaxia0.92734800
99MP0005084_abnormal_gallbladder_morpholo0.92414304
100MP0002254_reproductive_system_inflammat0.91711319
101MP0003011_delayed_dark_adaptation0.90224611
102MP0009046_muscle_twitch0.89512551
103MP0002693_abnormal_pancreas_physiology0.88945376
104MP0009785_altered_susceptibility_to0.88738763
105MP0001963_abnormal_hearing_physiology0.88156960
106MP0002928_abnormal_bile_duct0.87654445
107MP0005365_abnormal_bile_salt0.85968989
108MP0008789_abnormal_olfactory_epithelium0.83693352
109MP0002160_abnormal_reproductive_system0.82928998
110MP0000490_abnormal_crypts_of0.80710535
111MP0008995_early_reproductive_senescence0.80593495
112MP0002272_abnormal_nervous_system0.79306719
113MP0001984_abnormal_olfaction0.78893880
114MP0005058_abnormal_lysosome_morphology0.78452302
115MP0001270_distended_abdomen0.78445253
116MP0000026_abnormal_inner_ear0.78338463
117MP0003638_abnormal_response/metabolism_0.77058390
118MP0005448_abnormal_energy_balance0.76662527
119MP0005647_abnormal_sex_gland0.76220080
120MP0000566_synostosis0.76045670
121MP0003953_abnormal_hormone_level0.75436131
122MP0003787_abnormal_imprinting0.75289497
123MP0001800_abnormal_humoral_immune0.74659144
124MP0004782_abnormal_surfactant_physiolog0.74406791
125MP0009379_abnormal_foot_pigmentation0.73009544
126MP0003186_abnormal_redox_activity0.70475171
127MP0010155_abnormal_intestine_physiology0.70122732
128MP0000627_abnormal_mammary_gland0.69244740
129MP0008961_abnormal_basal_metabolism0.69066936
130MP0005451_abnormal_body_composition0.66862335
131MP0005220_abnormal_exocrine_pancreas0.66804880
132MP0000230_abnormal_systemic_arterial0.66596499
133MP0004885_abnormal_endolymph0.66026350
134MP0003183_abnormal_peptide_metabolism0.61737285
135MP0002998_abnormal_bone_remodeling0.61541010
136MP0005535_abnormal_body_temperature0.60495715
137MP0000762_abnormal_tongue_morphology0.59438175
138MP0003690_abnormal_glial_cell0.59395651
139MP0005584_abnormal_enzyme/coenzyme_acti0.59040437
140MP0003938_abnormal_ear_development0.58897578
141MP0004484_altered_response_of0.58554436
142MP0001764_abnormal_homeostasis0.57915476
143MP0003191_abnormal_cellular_cholesterol0.56232235
144MP0002557_abnormal_social/conspecific_i0.56055094
145MP0009642_abnormal_blood_homeostasis0.52463630
146MP0003724_increased_susceptibility_to0.51857324
147MP0009764_decreased_sensitivity_to0.50637098
148MP0000163_abnormal_cartilage_morphology0.50137370

Predicted human phenotypes

RankGene SetZ-score
1Metabolic alkalosis (HP:0200114)6.66062594
2Hyperactive renin-angiotensin system (HP:0000841)6.26170290
3Abnormality of chloride homeostasis (HP:0011422)5.74582731
4Gout (HP:0001997)5.02929900
5Hypomagnesemia (HP:0002917)4.90665243
6Abnormality of renal excretion (HP:0011036)4.71686731
7Polyuria (HP:0000103)4.46712317
8Proximal tubulopathy (HP:0000114)4.42165963
9Pancreatic cysts (HP:0001737)4.36280197
10Hypokalemic alkalosis (HP:0001949)4.32028984
11Abnormal urine output (HP:0012590)4.27618297
12Abnormality of renin-angiotensin system (HP:0000847)4.24291370
13Tetany (HP:0001281)4.21006540
14Abnormality of purine metabolism (HP:0004352)4.18334733
15Abnormality of magnesium homeostasis (HP:0004921)4.15147505
16Congenital stationary night blindness (HP:0007642)4.14659201
17Increased circulating renin level (HP:0000848)4.09387063
18Hyperaldosteronism (HP:0000859)4.05486251
19Hyperuricemia (HP:0002149)3.86222223
20Increased purine levels (HP:0004368)3.86222223
21True hermaphroditism (HP:0010459)3.66911541
22Ketoacidosis (HP:0001993)3.65686954
23Polydipsia (HP:0001959)3.63187298
24Abnormal drinking behavior (HP:0030082)3.63187298
25Pancreatic fibrosis (HP:0100732)3.51379193
26Alkalosis (HP:0001948)3.44358605
27Molar tooth sign on MRI (HP:0002419)3.42246834
28Abnormality of midbrain morphology (HP:0002418)3.42246834
29Congenital sensorineural hearing impairment (HP:0008527)3.37489887
30Abnormality of the renal medulla (HP:0100957)3.35248313
31Nephronophthisis (HP:0000090)3.32775739
32Hypokalemia (HP:0002900)3.29114667
33Abnormality of glutamine family amino acid metabolism (HP:0010902)3.23649336
34Decreased circulating renin level (HP:0003351)3.23110283
35Hypercalciuria (HP:0002150)3.22040907
36Attenuation of retinal blood vessels (HP:0007843)3.21444988
37Abnormality of urine glucose concentration (HP:0011016)3.18204431
38Glycosuria (HP:0003076)3.18204431
39Renal salt wasting (HP:0000127)3.17989425
40Hyperglycinuria (HP:0003108)2.94245673
41Ileus (HP:0002595)2.92328469
42Cystic liver disease (HP:0006706)2.89372570
43Delayed epiphyseal ossification (HP:0002663)2.86101908
44Abnormality of potassium homeostasis (HP:0011042)2.76482542
45Stomach cancer (HP:0012126)2.74762948
46Generalized aminoaciduria (HP:0002909)2.73901384
47Abnormality of nucleobase metabolism (HP:0010932)2.73038984
48Abnormal rod and cone electroretinograms (HP:0008323)2.72611209
49Abnormality of calcium-phosphate metabolism (HP:0100530)2.71473758
50Large for gestational age (HP:0001520)2.66598948
51Widely patent fontanelles and sutures (HP:0004492)2.65729663
52Hypophosphatemia (HP:0002148)2.62118798
53Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.60477846
54Abnormal urine phosphate concentration (HP:0012599)2.59856812
55Chronic hepatic failure (HP:0100626)2.59668268
56Type II lissencephaly (HP:0007260)2.59025361
57Metaphyseal irregularity (HP:0003025)2.57329293
58Dehydration (HP:0001944)2.55486529
59Decreased central vision (HP:0007663)2.54208972
60Abnormal respiratory epithelium morphology (HP:0012253)2.49107869
61Abnormal respiratory motile cilium morphology (HP:0005938)2.49107869
62Medial flaring of the eyebrow (HP:0010747)2.48786093
63Symptomatic seizures (HP:0011145)2.47108478
64Renal tubular acidosis (HP:0001947)2.46988819
65Abnormality of carpal bone ossification (HP:0006257)2.46830438
66Abolished electroretinogram (ERG) (HP:0000550)2.46822620
67Abnormality of macular pigmentation (HP:0008002)2.45483261
68Abnormal tarsal ossification (HP:0008369)2.42621515
69Hyperphosphaturia (HP:0003109)2.42238589
70Absent/shortened dynein arms (HP:0200106)2.40888978
71Dynein arm defect of respiratory motile cilia (HP:0012255)2.40888978
72Vacuolated lymphocytes (HP:0001922)2.40628671
73Hyperphosphatemia (HP:0002905)2.39862220
74Congenital, generalized hypertrichosis (HP:0004540)2.38588221
75Neonatal short-limb short stature (HP:0008921)2.37662035
76Osteomalacia (HP:0002749)2.37249451
77Gaze-evoked nystagmus (HP:0000640)2.37206406
78Flat acetabular roof (HP:0003180)2.36928445
79Lip pit (HP:0100267)2.33475082
80Enlarged epiphyses (HP:0010580)2.32422991
81Abnormality of renal resorption (HP:0011038)2.31448219
82Alveolar cell carcinoma (HP:0006519)2.30729022
83Tubular atrophy (HP:0000092)2.30716294
84Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.26729731
85Abnormality of alanine metabolism (HP:0010916)2.26729731
86Hyperalaninemia (HP:0003348)2.26729731
87Abnormal ciliary motility (HP:0012262)2.26327912
88Ketosis (HP:0001946)2.24602467
89Aplasia/Hypoplasia of the fovea (HP:0008060)2.24542390
90Hypoplasia of the fovea (HP:0007750)2.24542390
91Concave nail (HP:0001598)2.23002192
92Nephrocalcinosis (HP:0000121)2.22763400
93Rickets (HP:0002748)2.22234357
94Abnormality of serine family amino acid metabolism (HP:0010894)2.20236544
95Abnormality of glycine metabolism (HP:0010895)2.20236544
96Tubulointerstitial nephritis (HP:0001970)2.20035441
97Rhinitis (HP:0012384)2.17656690
98Hypothermia (HP:0002045)2.15164087
99Vascular calcification (HP:0004934)2.15131946
100Furrowed tongue (HP:0000221)2.14986176
101Unilateral renal agenesis (HP:0000122)2.14670217
102Stomatitis (HP:0010280)2.09144430
103Abnormality of the middle phalanges of the toes (HP:0010183)2.08128129
104Decreased electroretinogram (ERG) amplitude (HP:0000654)2.07530365
105Abnormal respiratory motile cilium physiology (HP:0012261)2.07294913
106Nephrolithiasis (HP:0000787)2.06934873
107Abnormality of proline metabolism (HP:0010907)2.06555405
108Hydroxyprolinuria (HP:0003080)2.06555405
109Amelogenesis imperfecta (HP:0000705)2.05796078
110Tubulointerstitial fibrosis (HP:0005576)2.01189912
111Aplasia/hypoplasia of the uterus (HP:0008684)2.00547829
112Hyperventilation (HP:0002883)2.00051535
113Inability to walk (HP:0002540)1.99930982
114Neoplasm of the tracheobronchial system (HP:0100552)1.99911617
115Malnutrition (HP:0004395)1.98424460
116Adrenal overactivity (HP:0002717)1.98147297
117Male pseudohermaphroditism (HP:0000037)1.96856191
118Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.96397382
119Congenital hepatic fibrosis (HP:0002612)1.96298141
120Cerebellar dysplasia (HP:0007033)1.95029839
121Abnormality of the fovea (HP:0000493)1.94966519
122Mitochondrial inheritance (HP:0001427)1.94460215
123Absent rod-and cone-mediated responses on ERG (HP:0007688)1.93791003
124Hypoplasia of the uterus (HP:0000013)1.93488527
125Keratoconus (HP:0000563)1.93421487
126Increased corneal curvature (HP:0100692)1.93421487
127Abnormal pancreas size (HP:0012094)1.92146946
128Symphalangism affecting the phalanges of the hand (HP:0009773)1.92018726
129Bony spicule pigmentary retinopathy (HP:0007737)1.91865073
130Hypoproteinemia (HP:0003075)1.91479849
131Bronchiectasis (HP:0002110)1.91305931
132Renal cortical cysts (HP:0000803)1.90382957
133Abnormality of the vitamin B12 metabolism (HP:0004341)1.89422290
134Metaphyseal dysplasia (HP:0100255)1.88758160
135Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.87574763
136Abnormality of the renal cortex (HP:0011035)1.87511210
137Pendular nystagmus (HP:0012043)1.87233038
138Increased CSF lactate (HP:0002490)1.86079679
139Tubulointerstitial abnormality (HP:0001969)1.85616545
140Sclerocornea (HP:0000647)1.85481531
141Chronic sinusitis (HP:0011109)1.85465940
142Hypophosphatemic rickets (HP:0004912)1.85364421
143Right ventricular cardiomyopathy (HP:0011663)1.84404830
144Methylmalonic aciduria (HP:0012120)1.84307722
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.84062873
146Flat capital femoral epiphysis (HP:0003370)1.83201996
147Methylmalonic acidemia (HP:0002912)1.83100794
148Abdominal distention (HP:0003270)1.82849997
149Renal tubular dysfunction (HP:0000124)1.82565703
150Absent speech (HP:0001344)1.82325904
151Hepatocellular necrosis (HP:0001404)1.80944869
152Metabolic acidosis (HP:0001942)1.80517225
153Abnormal hand bone ossification (HP:0010660)1.79482287
154Chronic bronchitis (HP:0004469)1.77735168
155Conjugated hyperbilirubinemia (HP:0002908)1.77233247
156Thyroiditis (HP:0100646)1.76747208
157Cardiovascular calcification (HP:0011915)1.76562889
158Hepatic necrosis (HP:0002605)1.75898818
159Abnormality of alkaline phosphatase activity (HP:0004379)1.75535064
160Late onset (HP:0003584)1.75378222
161Thin bony cortex (HP:0002753)1.74723432
162Short thorax (HP:0010306)1.74369551
163Progressive inability to walk (HP:0002505)1.73999737
164Sensorimotor neuropathy (HP:0007141)1.73309790
165Albinism (HP:0001022)1.72619786
166Pigmentary retinal degeneration (HP:0001146)1.72591997
167Congenital primary aphakia (HP:0007707)1.71230984
168Acute necrotizing encephalopathy (HP:0006965)1.70331094
169Nephrogenic diabetes insipidus (HP:0009806)1.69675199
170Rectal prolapse (HP:0002035)1.69382648
171Abnormality of vitamin B metabolism (HP:0004340)1.68895687
172Abnormal enzyme/coenzyme activity (HP:0012379)1.68705194
173Gait imbalance (HP:0002141)1.68569222
174Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.68152510
175Short middle phalanx of finger (HP:0005819)1.68059030

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK34.54688495
2MST1R4.44448159
3WNK44.20839071
4LMTK23.88234968
5OXSR13.68784072
6FRK3.54007318
7ACVR1B2.93474335
8STK38L2.77158660
9CASK2.58283543
10STK392.48396356
11IRAK32.34575751
12INSRR2.31098900
13YES12.28848389
14MAP4K22.15374665
15MST42.07701480
16SIK31.97914225
17TLK11.95048486
18TRPM71.72018919
19TXK1.64086646
20PIK3CA1.61245859
21SGK4941.53233133
22SGK2231.53233133
23PDK21.44175933
24MAP3K141.42036161
25TRIM281.41094213
26BCR1.33822025
27SGK21.32078913
28PRKG21.27569538
29MAPKAPK31.27060544
30RIPK41.24786046
31MAP3K21.24362277
32PDK41.21437775
33PDK31.21437775
34BMPR1B1.21054823
35EIF2AK31.21029920
36BCKDK1.20919471
37PRPF4B1.20758174
38NUAK11.20227930
39MET1.15932585
40LATS11.15179330
41EPHA31.13752268
42MAP2K71.13365921
43BMPR21.12852185
44IKBKB1.08611471
45MAPK151.08522197
46NLK1.07487668
47KIT1.04752139
48MAP3K121.01951951
49SGK30.99355649
50IRAK10.94334364
51WNK10.90577633
52TAOK30.90558454
53MYLK0.89362197
54NTRK30.88164063
55DAPK20.85267374
56FER0.82153178
57TNIK0.80820976
58CHUK0.77661825
59EPHB20.75400161
60TGFBR10.72408918
61MELK0.72286928
62TEC0.71029651
63STK380.70880153
64MAP2K20.70172373
65ITK0.69234274
66PTK2B0.68342176
67STK30.68225731
68FGFR20.68178640
69BRSK20.66132492
70CAMKK20.65429528
71IKBKE0.64922219
72FLT30.64746164
73ZAK0.64062888
74SGK10.63768301
75MAP2K60.62958809
76PRKCI0.61785126
77SIK10.61224602
78ERBB30.60343182
79AKT30.60317874
80NEK90.59964041
81PIK3CG0.59867842
82PRKAA10.59828406
83PRKCE0.55884177
84GRK10.55303519
85NME10.54683667
86GRK60.54191351
87MAP3K40.53818108
88PRKAA20.53743131
89PRKCG0.52492825
90DYRK1B0.52402341
91EIF2AK10.51423524
92EPHA20.51144102
93MKNK20.50783559
94CAMK2D0.49758504
95VRK20.48759024
96RIPK10.48025640
97ERBB20.47510706
98PHKG20.47355754
99PHKG10.47355754
100PAK30.47087961
101VRK10.46495273
102MAP2K10.45287541
103MUSK0.44754138
104CSNK1G10.44743555
105PINK10.44598005
106EIF2AK20.44265403
107GSK3A0.44047539
108RPS6KA50.43942669
109CAMK2B0.43833402
110CDK60.43591986
111MAPK130.43195460
112MAPKAPK50.42027127
113SYK0.41789686
114GRK50.41595956
115FGFR30.41500764
116CDK90.40928479
117TNK20.39165951
118TESK10.38372352
119PTK60.38297199
120MARK30.38254973
121CSNK1A10.38134908
122PRKACA0.37709201
123MAP3K70.37242603
124CSNK1G30.36332198
125MATK0.36053157
126IGF1R0.35258240
127CSNK1G20.35149210
128TIE10.35056099
129DYRK20.33552876
130PBK0.32507522
131STK110.32498065
132MAP4K10.32384102
133PRKCA0.32121427
134RPS6KB10.32068550
135HIPK20.31274473
136ERBB40.30935748
137CDK80.30136794
138ADRBK10.30023711
139CDK30.29728830
140ABL10.29111127
141CSNK1A1L0.29066226
142CAMK2A0.28996897
143MAPK110.28819250
144EPHB10.26953488
145MAP2K40.25001205
146PRKCQ0.24659289
147NEK60.23744035
148CSK0.22140912
149ADRBK20.21620568
150CDC42BPA0.21592855

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009204.72474808
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.29088781
3Nitrogen metabolism_Homo sapiens_hsa009103.05870179
4Mineral absorption_Homo sapiens_hsa049783.01159184
5Butanoate metabolism_Homo sapiens_hsa006502.89835971
6Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.63984060
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.52640397
8Propanoate metabolism_Homo sapiens_hsa006402.48277828
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.43397405
10Vitamin digestion and absorption_Homo sapiens_hsa049772.37615934
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.04436737
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.93991694
13Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.89850563
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.86344541
15Fatty acid biosynthesis_Homo sapiens_hsa000611.79110504
16Pyruvate metabolism_Homo sapiens_hsa006201.78591351
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.73369211
18* Intestinal immune network for IgA production_Homo sapiens_hsa046721.70861772
19Tryptophan metabolism_Homo sapiens_hsa003801.70213323
20Peroxisome_Homo sapiens_hsa041461.61557969
21beta-Alanine metabolism_Homo sapiens_hsa004101.61264549
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.60249481
23Asthma_Homo sapiens_hsa053101.55708853
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.54150201
25Histidine metabolism_Homo sapiens_hsa003401.46339549
26Fatty acid degradation_Homo sapiens_hsa000711.42149266
27Protein export_Homo sapiens_hsa030601.38807722
28Fatty acid metabolism_Homo sapiens_hsa012121.38054501
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37827135
30Autoimmune thyroid disease_Homo sapiens_hsa053201.32692891
31Primary bile acid biosynthesis_Homo sapiens_hsa001201.32026740
32Bile secretion_Homo sapiens_hsa049761.31740156
33Collecting duct acid secretion_Homo sapiens_hsa049661.29809520
34Arachidonic acid metabolism_Homo sapiens_hsa005901.29640544
35Other glycan degradation_Homo sapiens_hsa005111.28304656
36Glutathione metabolism_Homo sapiens_hsa004801.26430680
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.25660206
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23894137
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22260400
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17067940
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.15240705
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08777741
43Homologous recombination_Homo sapiens_hsa034401.07973825
44Protein digestion and absorption_Homo sapiens_hsa049741.07383358
45Graft-versus-host disease_Homo sapiens_hsa053321.06446888
46Type I diabetes mellitus_Homo sapiens_hsa049401.05916794
47Linoleic acid metabolism_Homo sapiens_hsa005911.05551596
48Ovarian steroidogenesis_Homo sapiens_hsa049131.05544421
49Galactose metabolism_Homo sapiens_hsa000521.05232613
50Sphingolipid metabolism_Homo sapiens_hsa006001.05014393
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.04404787
52Thyroid hormone synthesis_Homo sapiens_hsa049181.04156574
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.03883299
54Allograft rejection_Homo sapiens_hsa053301.03606803
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00265353
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99764589
57Starch and sucrose metabolism_Homo sapiens_hsa005000.97591332
58Ether lipid metabolism_Homo sapiens_hsa005650.94667259
59Sulfur relay system_Homo sapiens_hsa041220.93221168
60Caffeine metabolism_Homo sapiens_hsa002320.92135612
61Parkinsons disease_Homo sapiens_hsa050120.91124938
62Arginine and proline metabolism_Homo sapiens_hsa003300.88652960
63PPAR signaling pathway_Homo sapiens_hsa033200.85560521
64Drug metabolism - other enzymes_Homo sapiens_hsa009830.83788982
65Fanconi anemia pathway_Homo sapiens_hsa034600.82691874
66Primary immunodeficiency_Homo sapiens_hsa053400.78094355
67Vibrio cholerae infection_Homo sapiens_hsa051100.77846105
68Folate biosynthesis_Homo sapiens_hsa007900.77632494
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.75638214
70RNA polymerase_Homo sapiens_hsa030200.75606154
71Lysine degradation_Homo sapiens_hsa003100.73313702
72Fructose and mannose metabolism_Homo sapiens_hsa000510.71574392
73* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.68630922
74Olfactory transduction_Homo sapiens_hsa047400.68503189
75Nicotine addiction_Homo sapiens_hsa050330.67067607
76Huntingtons disease_Homo sapiens_hsa050160.66378092
77Oxidative phosphorylation_Homo sapiens_hsa001900.65485219
78Glycerolipid metabolism_Homo sapiens_hsa005610.64484314
79Proteasome_Homo sapiens_hsa030500.64279821
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63449475
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.62764834
82GnRH signaling pathway_Homo sapiens_hsa049120.62100739
83Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61507989
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60736546
85Rheumatoid arthritis_Homo sapiens_hsa053230.60478655
86Gastric acid secretion_Homo sapiens_hsa049710.60201348
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59927308
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.59885412
89Steroid biosynthesis_Homo sapiens_hsa001000.59804648
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.59437119
91Regulation of autophagy_Homo sapiens_hsa041400.59219364
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59148758
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58886648
94Dorso-ventral axis formation_Homo sapiens_hsa043200.58458756
95Salivary secretion_Homo sapiens_hsa049700.58078569
96Tyrosine metabolism_Homo sapiens_hsa003500.54596650
97Pancreatic secretion_Homo sapiens_hsa049720.54421511
98Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53693061
99Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53645032
100Basal transcription factors_Homo sapiens_hsa030220.52857068
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51623251
102Lysosome_Homo sapiens_hsa041420.51512114
103Insulin secretion_Homo sapiens_hsa049110.51057296
104Metabolic pathways_Homo sapiens_hsa011000.50845085
105Type II diabetes mellitus_Homo sapiens_hsa049300.49538740
106Carbon metabolism_Homo sapiens_hsa012000.48827909
107N-Glycan biosynthesis_Homo sapiens_hsa005100.47131167
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.46907022
109ABC transporters_Homo sapiens_hsa020100.46906880
110Fat digestion and absorption_Homo sapiens_hsa049750.44845863
111Hematopoietic cell lineage_Homo sapiens_hsa046400.44081689
112Renin-angiotensin system_Homo sapiens_hsa046140.43966501
113Phototransduction_Homo sapiens_hsa047440.42761672
114Circadian rhythm_Homo sapiens_hsa047100.42350872
115Purine metabolism_Homo sapiens_hsa002300.42103357
116Hepatitis C_Homo sapiens_hsa051600.41517741
117RNA degradation_Homo sapiens_hsa030180.40306201
118Fatty acid elongation_Homo sapiens_hsa000620.40230151
119Morphine addiction_Homo sapiens_hsa050320.39963849
120One carbon pool by folate_Homo sapiens_hsa006700.38741188
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38461260
122Prolactin signaling pathway_Homo sapiens_hsa049170.37856140
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.37344521
124Taste transduction_Homo sapiens_hsa047420.35185098
125Chemical carcinogenesis_Homo sapiens_hsa052040.34116780
126Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34019738
127Selenocompound metabolism_Homo sapiens_hsa004500.32841844
128Inositol phosphate metabolism_Homo sapiens_hsa005620.32596734
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.32294188
130Renin secretion_Homo sapiens_hsa049240.31379792
131Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31104155
132Antigen processing and presentation_Homo sapiens_hsa046120.30262211
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29425319
134Serotonergic synapse_Homo sapiens_hsa047260.28302630
135Tight junction_Homo sapiens_hsa045300.25677655
136Retinol metabolism_Homo sapiens_hsa008300.24562088
137Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.23519911
138Alzheimers disease_Homo sapiens_hsa050100.22418350
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.22288147
140FoxO signaling pathway_Homo sapiens_hsa040680.21519301

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