CCL27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of water loss via skin (GO:0033561)9.58842451
2keratinocyte proliferation (GO:0043616)7.26476452
3desmosome organization (GO:0002934)7.15740018
4intermediate filament organization (GO:0045109)5.97903223
5multicellular organismal water homeostasis (GO:0050891)5.84305323
6keratinocyte differentiation (GO:0030216)5.77202607
7fatty acid elongation (GO:0030497)5.42595137
8lateral sprouting from an epithelium (GO:0060601)4.91119567
9epidermal cell differentiation (GO:0009913)4.85232198
10water homeostasis (GO:0030104)4.81539622
11hair cycle (GO:0042633)4.79155705
12molting cycle (GO:0042303)4.79155705
13long-chain fatty acid biosynthetic process (GO:0042759)4.59332760
14peptide cross-linking (GO:0018149)4.55715006
15epidermis development (GO:0008544)4.48122163
16axon ensheathment in central nervous system (GO:0032291)4.46327705
17central nervous system myelination (GO:0022010)4.46327705
18intermediate filament cytoskeleton organization (GO:0045104)4.36938095
19intermediate filament-based process (GO:0045103)4.25135611
20regulation of axon regeneration (GO:0048679)4.18588042
21regulation of neuron projection regeneration (GO:0070570)4.18588042
22cerebral cortex radially oriented cell migration (GO:0021799)4.03432837
23linoleic acid metabolic process (GO:0043651)3.90430371
24pyrimidine nucleobase catabolic process (GO:0006208)3.88410613
25neuron cell-cell adhesion (GO:0007158)3.75389345
26negative regulation of astrocyte differentiation (GO:0048712)3.74344905
27presynaptic membrane assembly (GO:0097105)3.68018213
28tongue development (GO:0043586)3.67594631
29establishment of planar polarity (GO:0001736)3.66295512
30establishment of tissue polarity (GO:0007164)3.66295512
31acrosome reaction (GO:0007340)3.65760405
32behavioral response to nicotine (GO:0035095)3.53390356
33polyol transport (GO:0015791)3.37054871
34central nervous system projection neuron axonogenesis (GO:0021952)3.33609588
35sperm motility (GO:0030317)3.29909454
36postsynaptic membrane organization (GO:0001941)3.27030124
37positive regulation of glomerulus development (GO:0090193)3.25522159
38cerebral cortex neuron differentiation (GO:0021895)3.23103407
39presynaptic membrane organization (GO:0097090)3.22296055
40neurofilament cytoskeleton organization (GO:0060052)3.15109943
41otic vesicle formation (GO:0030916)3.14442099
42negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.11334001
43regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.07999787
44keratinocyte development (GO:0003334)3.06057794
45regulation of keratinocyte proliferation (GO:0010837)3.03553314
46axonal fasciculation (GO:0007413)3.02609348
47ionotropic glutamate receptor signaling pathway (GO:0035235)2.94117201
48central nervous system neuron axonogenesis (GO:0021955)2.94029399
49negative regulation of keratinocyte proliferation (GO:0010839)2.94027351
50phosphatidylinositol acyl-chain remodeling (GO:0036149)2.89913758
51axonemal dynein complex assembly (GO:0070286)2.84219600
52negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.83676399
53nucleobase catabolic process (GO:0046113)2.81908060
54motile cilium assembly (GO:0044458)2.81128846
55one-carbon compound transport (GO:0019755)2.80445231
56cranial nerve morphogenesis (GO:0021602)2.80321155
57spermatid nucleus differentiation (GO:0007289)2.79244098
58epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.77095374
59ceramide biosynthetic process (GO:0046513)2.75023263
60protein targeting to Golgi (GO:0000042)2.74883326
61sulfation (GO:0051923)2.73856797
62hair cell differentiation (GO:0035315)2.68620682
63mechanoreceptor differentiation (GO:0042490)2.67395195
64fusion of sperm to egg plasma membrane (GO:0007342)2.66662136
65negative regulation of inclusion body assembly (GO:0090084)2.64160928
66regulation of autophagic vacuole assembly (GO:2000785)2.63469385
67coenzyme catabolic process (GO:0009109)2.63252733
68epithelial cilium movement (GO:0003351)2.61176544
69neuromuscular synaptic transmission (GO:0007274)2.59298343
70positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.57807331
71establishment of protein localization to Golgi (GO:0072600)2.57247994
72spermatid development (GO:0007286)2.53845784
73retrograde transport, vesicle recycling within Golgi (GO:0000301)2.52402742
74dendritic spine morphogenesis (GO:0060997)2.51916520
75calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.51456772
76protein polyglutamylation (GO:0018095)2.50336051
77regulation of vacuole organization (GO:0044088)2.47047832
78regulation of neuron migration (GO:2001222)2.46986238
79negative regulation of dendrite development (GO:2000171)2.46155282
80phosphatidylserine acyl-chain remodeling (GO:0036150)2.45439668
81limb bud formation (GO:0060174)2.45189066
82dermatan sulfate biosynthetic process (GO:0030208)2.45118568
83axon regeneration (GO:0031103)2.43943580
84heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.43925477
85pattern specification involved in kidney development (GO:0061004)2.43671595
86polarized epithelial cell differentiation (GO:0030859)2.40529662
87response to acidic pH (GO:0010447)2.40517617
88locomotory exploration behavior (GO:0035641)2.40468714
89somite development (GO:0061053)2.39789488
90negative regulation of glial cell differentiation (GO:0045686)2.35818845
91myelination in peripheral nervous system (GO:0022011)2.33869510
92peripheral nervous system axon ensheathment (GO:0032292)2.33869510
93digestive tract morphogenesis (GO:0048546)2.33416519
94epithelium development (GO:0060429)2.32943519
95apical protein localization (GO:0045176)2.32711964
96cell proliferation in forebrain (GO:0021846)2.29534789
97dendritic spine organization (GO:0097061)2.29119646
98bundle of His cell to Purkinje myocyte communication (GO:0086069)2.28697471
99keratinization (GO:0031424)13.4581016
100establishment of skin barrier (GO:0061436)11.6030294

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human3.76501133
2EZH2_22144423_ChIP-Seq_EOC_Human3.28189845
3GBX2_23144817_ChIP-Seq_PC3_Human2.92200625
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.72440185
5FUS_26573619_Chip-Seq_HEK293_Human2.72385840
6AR_21572438_ChIP-Seq_LNCaP_Human2.65987250
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.44764456
8IGF1R_20145208_ChIP-Seq_DFB_Human2.36005250
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.17309361
10CBX2_27304074_Chip-Seq_ESCs_Mouse2.16903897
11POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.12217525
12TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12217525
13RXR_22108803_ChIP-Seq_LS180_Human2.05913264
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01547360
15CTBP2_25329375_ChIP-Seq_LNCAP_Human1.98483758
16EZH2_27304074_Chip-Seq_ESCs_Mouse1.96348891
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.95468941
18P300_19829295_ChIP-Seq_ESCs_Human1.91665710
19SUZ12_27294783_Chip-Seq_ESCs_Mouse1.81540177
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79609813
21SALL1_21062744_ChIP-ChIP_HESCs_Human1.75700700
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73844670
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.73048990
24SMAD3_21741376_ChIP-Seq_EPCs_Human1.72599953
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.68717677
26JARID2_20075857_ChIP-Seq_MESCs_Mouse1.68432774
27EED_16625203_ChIP-ChIP_MESCs_Mouse1.67831613
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67482556
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.66414360
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65207243
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65207243
32SMAD4_21799915_ChIP-Seq_A2780_Human1.63610819
33TAF15_26573619_Chip-Seq_HEK293_Human1.63185959
34SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.62951755
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.55952198
36* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.54873197
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54518023
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52169850
39RNF2_27304074_Chip-Seq_ESCs_Mouse1.51725075
40AR_25329375_ChIP-Seq_VCAP_Human1.48894065
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47338465
42CBP_20019798_ChIP-Seq_JUKART_Human1.47338465
43UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46557208
44TP53_18474530_ChIP-ChIP_U2OS_Human1.45317886
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.40764947
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.40658406
47PIAS1_25552417_ChIP-Seq_VCAP_Human1.40556510
48* TP63_23658742_ChIP-Seq_EP156T_Human1.40061689
49ZNF274_21170338_ChIP-Seq_K562_Hela1.38966575
50REST_21632747_ChIP-Seq_MESCs_Mouse1.38362675
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37289857
52ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.35883335
53POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34060008
54AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.33412491
55ARNT_22903824_ChIP-Seq_MCF-7_Human1.31966932
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31311753
57TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30222949
58RUNX2_22187159_ChIP-Seq_PCA_Human1.29605408
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.29028066
60CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27641194
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27401932
62RNF2_27304074_Chip-Seq_NSC_Mouse1.27327870
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.27174608
64CTCF_27219007_Chip-Seq_Bcells_Human1.26221077
65SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23231523
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22962484
67NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22666177
68MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21895267
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21411495
70P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19600552
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18843672
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17869313
73SRY_22984422_ChIP-ChIP_TESTIS_Rat1.17651070
74WDR5_24793694_ChIP-Seq_LNCAP_Human1.17441808
75SMAD3_21741376_ChIP-Seq_ESCs_Human1.17376054
76EWS_26573619_Chip-Seq_HEK293_Human1.16876445
77ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16333490
78ERG_20517297_ChIP-Seq_VCAP_Human1.15610686
79TCF4_18268006_ChIP-ChIP_LS174T_Human1.14943350
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11387862
81TBL1_22424771_ChIP-Seq_293T_Human1.11025652
82CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09911999
83OCT1_27270436_Chip-Seq_PROSTATE_Human1.08273373
84MTF2_20144788_ChIP-Seq_MESCs_Mouse1.07676970
85ER_23166858_ChIP-Seq_MCF-7_Human1.06528618
86TCF4_22108803_ChIP-Seq_LS180_Human1.04854875
87AHR_22903824_ChIP-Seq_MCF-7_Human1.04790432
88HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.04651225
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04296558
90LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03478583
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.02519733
92* TP63_22573176_ChIP-Seq_HFKS_Human1.02279340
93GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01528476
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01266667
95VDR_22108803_ChIP-Seq_LS180_Human1.00788854
96POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99665399
97STAT3_23295773_ChIP-Seq_U87_Human0.99618055
98SMAD4_21741376_ChIP-Seq_EPCs_Human0.99142205
99GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99049758
100ERG_21242973_ChIP-ChIP_JURKAT_Human0.96729420

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.56981821
2MP0009379_abnormal_foot_pigmentation5.75903064
3MP0005275_abnormal_skin_tensile5.18445799
4MP0010234_abnormal_vibrissa_follicle3.78665802
5MP0005501_abnormal_skin_physiology3.67778311
6MP0001188_hyperpigmentation3.66905286
7MP0000566_synostosis2.84713754
8MP0004381_abnormal_hair_follicle2.78173862
9MP0000579_abnormal_nail_morphology2.44816758
10MP0005174_abnormal_tail_pigmentation2.39153365
11MP0003011_delayed_dark_adaptation2.32534921
12MP0004885_abnormal_endolymph2.20546652
13MP0003136_yellow_coat_color2.15945041
14MP0002638_abnormal_pupillary_reflex2.12673977
15MP0002095_abnormal_skin_pigmentation2.10515679
16MP0001216_abnormal_epidermal_layer2.08784492
17MP0000647_abnormal_sebaceous_gland1.99387563
18MP0002822_catalepsy1.95400040
19MP0010771_integument_phenotype1.93688698
20MP0010678_abnormal_skin_adnexa1.89596791
21MP0003453_abnormal_keratinocyte_physiol1.88268799
22MP0000383_abnormal_hair_follicle1.69479264
23MP0000377_abnormal_hair_follicle1.69203127
24MP0000015_abnormal_ear_pigmentation1.61297777
25MP0000778_abnormal_nervous_system1.61073774
26MP0002735_abnormal_chemical_nociception1.59231860
27MP0000427_abnormal_hair_cycle1.54277407
28MP0001984_abnormal_olfaction1.53458310
29MP0004782_abnormal_surfactant_physiolog1.51422061
30MP0005171_absent_coat_pigmentation1.49870107
31MP0002098_abnormal_vibrissa_morphology1.43395466
32MP0000762_abnormal_tongue_morphology1.41564671
33MP0005409_darkened_coat_color1.36947736
34MP0003315_abnormal_perineum_morphology1.31428560
35MP0005410_abnormal_fertilization1.30144633
36MP0005394_taste/olfaction_phenotype1.28498522
37MP0005499_abnormal_olfactory_system1.28498522
38MP0002102_abnormal_ear_morphology1.26609150
39MP0000049_abnormal_middle_ear1.26130118
40MP0002234_abnormal_pharynx_morphology1.24549755
41MP0004859_abnormal_synaptic_plasticity1.22951858
42MP0010030_abnormal_orbit_morphology1.21403483
43MP0000467_abnormal_esophagus_morphology1.21047687
44MP0008789_abnormal_olfactory_epithelium1.19975297
45MP0002282_abnormal_trachea_morphology1.18017768
46MP0003890_abnormal_embryonic-extraembry1.11920614
47MP0004947_skin_inflammation1.11041309
48MP0002060_abnormal_skin_morphology1.10830430
49MP0002177_abnormal_outer_ear1.08462173
50MP0003705_abnormal_hypodermis_morpholog1.08342540
51MP0010386_abnormal_urinary_bladder1.05870813
52MP0002653_abnormal_ependyma_morphology1.05500411
53MP0002233_abnormal_nose_morphology1.04723379
54MP0003755_abnormal_palate_morphology1.03412640
55MP0003880_abnormal_central_pattern1.01345289
56MP0000537_abnormal_urethra_morphology0.96789413
57MP0001299_abnormal_eye_distance/0.95848940
58MP0003941_abnormal_skin_development0.95129067
59MP0000367_abnormal_coat/_hair0.94180899
60MP0003698_abnormal_male_reproductive0.93392978
61MP0005248_abnormal_Harderian_gland0.92937058
62MP0009931_abnormal_skin_appearance0.92115502
63MP0000026_abnormal_inner_ear0.89888350
64MP0004270_analgesia0.86483949
65MP0005253_abnormal_eye_physiology0.86103573
66MP0005075_abnormal_melanosome_morpholog0.85938774
67MP0001191_abnormal_skin_condition0.84241882
68MP0009053_abnormal_anal_canal0.80917127
69MP0003635_abnormal_synaptic_transmissio0.79902018
70MP0002249_abnormal_larynx_morphology0.78767060
71MP0000631_abnormal_neuroendocrine_gland0.77965356
72MP0006072_abnormal_retinal_apoptosis0.77952874
73MP0002572_abnormal_emotion/affect_behav0.73583905
74MP0002063_abnormal_learning/memory/cond0.73277966
75MP0001340_abnormal_eyelid_morphology0.72252231
76MP0003718_maternal_effect0.70968533
77MP0005391_vision/eye_phenotype0.69577399
78MP0000428_abnormal_craniofacial_morphol0.68822065
79MP0006276_abnormal_autonomic_nervous0.65097865
80MP0001929_abnormal_gametogenesis0.64920981
81MP0005503_abnormal_tendon_morphology0.64539211
82MP0002160_abnormal_reproductive_system0.63278261
83MP0002184_abnormal_innervation0.62815611
84MP0005551_abnormal_eye_electrophysiolog0.61758188
85MP0001177_atelectasis0.61472632
86MP0008569_lethality_at_weaning0.61182418
87MP0003938_abnormal_ear_development0.59932021
88MP0001968_abnormal_touch/_nociception0.59917301
89MP0003119_abnormal_digestive_system0.57278613
90MP0000432_abnormal_head_morphology0.57053323
91MP0001243_abnormal_dermal_layer0.55008308
92MP0003935_abnormal_craniofacial_develop0.54822125
93MP0005377_hearing/vestibular/ear_phenot0.54714334
94MP0003878_abnormal_ear_physiology0.54714334
95MP0001970_abnormal_pain_threshold0.54021657
96MP0002882_abnormal_neuron_morphology0.53837035
97MP0009250_abnormal_appendicular_skeleto0.53657593
98MP0001485_abnormal_pinna_reflex0.53453197
99MP0002090_abnormal_vision0.52080122
100MP0002752_abnormal_somatic_nervous0.51569676

Predicted human phenotypes

RankGene SetZ-score
1Increased IgE level (HP:0003212)6.87222807
2Erythroderma (HP:0001019)6.72009460
3Palmoplantar hyperkeratosis (HP:0000972)5.99062041
4Palmar hyperkeratosis (HP:0010765)5.93623847
5Erythema (HP:0010783)5.62721628
6Congenital ichthyosiform erythroderma (HP:0007431)5.41381709
7Abnormality of nail color (HP:0100643)5.37703333
8Hypotrichosis (HP:0001006)5.34798902
9Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.03643831
10Conjunctival hamartoma (HP:0100780)4.95673770
11Plantar hyperkeratosis (HP:0007556)4.73695864
12Thick nail (HP:0001805)4.55089229
13Abnormality of secondary sexual hair (HP:0009888)4.34566121
14Abnormality of the axillary hair (HP:0100134)4.34566121
15Parakeratosis (HP:0001036)4.17913076
16Fragile nails (HP:0001808)3.60020529
17Alopecia of scalp (HP:0002293)3.46847747
18Woolly hair (HP:0002224)3.44844560
19Palmoplantar keratoderma (HP:0000982)3.35324614
20Corneal erosion (HP:0200020)3.33669678
21Hamartoma of the eye (HP:0010568)3.26902719
22Split foot (HP:0001839)3.09870241
23Septo-optic dysplasia (HP:0100842)3.03981305
24Sparse scalp hair (HP:0002209)2.87226562
25Aplasia involving bones of the upper limbs (HP:0009823)2.80614133
26Aplasia of the phalanges of the hand (HP:0009802)2.80614133
27Aplasia involving bones of the extremities (HP:0009825)2.80614133
28Hamartoma (HP:0010566)2.75041934
29Right ventricular cardiomyopathy (HP:0011663)2.69578469
30Ulnar claw (HP:0001178)2.67977171
31Abnormality of the columella (HP:0009929)2.58197266
32Absent/shortened dynein arms (HP:0200106)2.56491019
33Dynein arm defect of respiratory motile cilia (HP:0012255)2.56491019
34Nasolacrimal duct obstruction (HP:0000579)2.49038354
35Hypoplastic labia majora (HP:0000059)2.45441597
36Hypohidrosis (HP:0000966)2.43592865
37Onycholysis (HP:0001806)2.36640017
38Abnormality of the dental root (HP:0006486)2.33325604
39Taurodontia (HP:0000679)2.33325604
40Abnormality of permanent molar morphology (HP:0011071)2.33325604
41Conical tooth (HP:0000698)2.33150242
42Abnormality of the labia majora (HP:0012881)2.30461546
43Segmental peripheral demyelination/remyelination (HP:0003481)2.21420648
44Optic nerve hypoplasia (HP:0000609)2.20933042
45Abnormality of the salivary glands (HP:0010286)2.20586709
46Abnormality of molar (HP:0011077)2.16998883
47Abnormality of molar morphology (HP:0011070)2.16998883
48Abnormal blistering of the skin (HP:0008066)2.16124984
49Melanocytic nevus (HP:0000995)2.13694973
50Alacrima (HP:0000522)2.10126185
51Gangrene (HP:0100758)2.07969971
52Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.03946249
53Mixed hearing impairment (HP:0000410)2.03038699
54Abnormality of the dental pulp (HP:0006479)2.02803153
55Depressed nasal tip (HP:0000437)1.99918299
56Coronal craniosynostosis (HP:0004440)1.99315789
57Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.97410872
58Absent septum pellucidum (HP:0001331)1.97275223
59Abnormal ciliary motility (HP:0012262)1.96383808
60Long nose (HP:0003189)1.95665207
61Labial hypoplasia (HP:0000066)1.91096597
62Abnormal respiratory motile cilium physiology (HP:0012261)1.90765124
63Median cleft lip (HP:0000161)1.89741807
64Oligodontia (HP:0000677)1.89240441
65Duplicated collecting system (HP:0000081)1.88826867
66Ectropion (HP:0000656)1.88353896
67Abnormality of the lacrimal duct (HP:0011481)1.87714495
68Lip pit (HP:0100267)1.86757533
69Abnormality of hair growth rate (HP:0011363)1.83479034
70Slow-growing hair (HP:0002217)1.83479034
71Megalencephaly (HP:0001355)1.82631780
72Acanthosis nigricans (HP:0000956)1.80979077
73Recurrent corneal erosions (HP:0000495)1.79534054
74Abnormality of the septum pellucidum (HP:0007375)1.79404003
75Abnormality of the renal collecting system (HP:0004742)1.78411828
76Esophageal atresia (HP:0002032)1.77476380
77Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76382572
78Decreased lacrimation (HP:0000633)1.76144105
79Curly hair (HP:0002212)1.75995986
80Steppage gait (HP:0003376)1.75196464
81Thickened helices (HP:0000391)1.74270296
82Hypoplastic female external genitalia (HP:0012815)1.73650475
83Laryngomalacia (HP:0001601)1.72035633
84Furrowed tongue (HP:0000221)1.70515522
85Atonic seizures (HP:0010819)1.69924842
86Xerostomia (HP:0000217)1.69020463
87Shoulder girdle muscle weakness (HP:0003547)1.66668778
88Pruritus (HP:0000989)1.66450171
89Renal dysplasia (HP:0000110)1.63272193
90Upper limb muscle weakness (HP:0003484)1.62680086
91Absent eyelashes (HP:0000561)1.60077513
92Nail dystrophy (HP:0008404)1.58701277
93Abnormal respiratory epithelium morphology (HP:0012253)1.58328106
94Abnormal respiratory motile cilium morphology (HP:0005938)1.58328106
95Gait imbalance (HP:0002141)1.57861389
96Abnormality of incisor morphology (HP:0011063)1.57739716
97Polyphagia (HP:0002591)1.57029746
98Oral leukoplakia (HP:0002745)1.53762115
99High anterior hairline (HP:0009890)1.52611309
100Abnormality of the labia (HP:0000058)1.52603099

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.06217370
2PINK13.93613296
3STK243.62512129
4TGFBR13.02204268
5STK38L2.77509007
6MARK12.76913358
7NTRK22.69624945
8LATS12.64113968
9SGK4942.21206011
10SGK2232.21206011
11SIK22.05532853
12TYRO31.93999074
13TAF11.84830319
14DYRK31.78603359
15BMPR1B1.75754590
16EPHB21.53113561
17PRKD31.49721863
18FGFR21.49354316
19PNCK1.47128122
20DYRK21.46660530
21WNK31.39900328
22SGK21.35572248
23MAPK151.34766092
24MARK31.33381705
25MOS1.31588460
26CDK31.30963580
27MAPK131.21671752
28CDK191.16257229
29MAP3K61.13975722
30FGFR11.13328481
31NEK21.07552676
32PLK41.03442055
33DDR20.99469632
34EPHA40.98798980
35PKN10.97290295
36WEE10.96830548
37MAPKAPK50.95491186
38STK30.92602578
39STK380.91727524
40DYRK1B0.87977729
41OBSCN0.86960322
42PIK3CG0.86566932
43CDK50.86308151
44ACVR1B0.83693870
45MAP2K70.82067458
46MAPK120.81691153
47MAP4K20.81069849
48INSRR0.80687829
49MAPK70.80012658
50DMPK0.79712762
51PRKCG0.78087559
52PAK30.75913224
53NTRK30.75386277
54RPS6KB10.74726829
55KSR10.69323156
56PRKCE0.67654880
57AKT30.66259830
58SGK30.65122986
59CSNK1G20.64665001
60KSR20.64469174
61PDGFRB0.62902235
62CSNK1A1L0.59093974
63FGR0.58698077
64ARAF0.57328629
65PAK60.56832291
66CSNK1G10.56455827
67CSNK1G30.54383351
68GSK3A0.54258821
69ROCK10.53924599
70EPHA30.53888421
71ADRBK10.53630578
72UHMK10.53208291
73LATS20.53129777
74FRK0.52946929
75BCR0.52028161
76DYRK1A0.50792637
77MINK10.50383237
78MYLK0.49902680
79PLK20.48051951
80RAF10.45156771
81NLK0.45130165
82PRKCZ0.44934972
83TLK10.43778962
84PRPF4B0.42778649
85RPS6KA40.42245820
86WNK10.42082943
87RPS6KA50.41724501
88TAOK30.39566234
89ERBB30.38390803
90FGFR30.38098602
91CDK140.37975019
92PAK20.35093106
93SGK10.34408515
94MAP3K40.34313856
95MAPKAPK30.32963482
96IRAK20.29038861
97CCNB10.27593442
98CAMK10.27455392
99EEF2K0.27172600
100MAP3K90.26110808

Predicted pathways (KEGG)

RankGene SetZ-score
1alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.51423473
2Circadian rhythm_Homo sapiens_hsa047102.82684086
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.80150661
4Linoleic acid metabolism_Homo sapiens_hsa005912.64414112
5Phototransduction_Homo sapiens_hsa047442.47082260
6Olfactory transduction_Homo sapiens_hsa047402.24787018
7Ether lipid metabolism_Homo sapiens_hsa005652.02057655
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.97362706
9Nicotine addiction_Homo sapiens_hsa050331.96977518
10Hedgehog signaling pathway_Homo sapiens_hsa043401.76068300
11Long-term depression_Homo sapiens_hsa047301.54008285
12Gap junction_Homo sapiens_hsa045401.53803756
13Glutamatergic synapse_Homo sapiens_hsa047241.50521330
14Taste transduction_Homo sapiens_hsa047421.47357212
15Dorso-ventral axis formation_Homo sapiens_hsa043201.44321688
16beta-Alanine metabolism_Homo sapiens_hsa004101.41439944
17Nitrogen metabolism_Homo sapiens_hsa009101.39240660
18Axon guidance_Homo sapiens_hsa043601.37879747
19Oxytocin signaling pathway_Homo sapiens_hsa049211.37186492
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.33626327
21Choline metabolism in cancer_Homo sapiens_hsa052311.32388792
22Cocaine addiction_Homo sapiens_hsa050301.29875318
23Circadian entrainment_Homo sapiens_hsa047131.27633322
24Histidine metabolism_Homo sapiens_hsa003401.27356745
25Basal transcription factors_Homo sapiens_hsa030221.26887884
26Melanogenesis_Homo sapiens_hsa049161.26163729
27Fatty acid elongation_Homo sapiens_hsa000621.26050150
28Amphetamine addiction_Homo sapiens_hsa050311.24909877
29Sphingolipid metabolism_Homo sapiens_hsa006001.17606511
30Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.16821636
31Arachidonic acid metabolism_Homo sapiens_hsa005901.16367254
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14891387
33Glycerophospholipid metabolism_Homo sapiens_hsa005641.14100194
34Vascular smooth muscle contraction_Homo sapiens_hsa042701.12580758
35Dopaminergic synapse_Homo sapiens_hsa047281.12297487
36GABAergic synapse_Homo sapiens_hsa047271.12248260
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.11999311
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.09738324
39Oocyte meiosis_Homo sapiens_hsa041141.06238061
40GnRH signaling pathway_Homo sapiens_hsa049121.05680487
41Aldosterone synthesis and secretion_Homo sapiens_hsa049251.05301620
42Estrogen signaling pathway_Homo sapiens_hsa049151.04074610
43Hippo signaling pathway_Homo sapiens_hsa043901.02228786
44Retinol metabolism_Homo sapiens_hsa008301.02016706
45Butanoate metabolism_Homo sapiens_hsa006501.01298538
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.00007517
47Renin secretion_Homo sapiens_hsa049240.95657411
48Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94444472
49cAMP signaling pathway_Homo sapiens_hsa040240.91718209
50Long-term potentiation_Homo sapiens_hsa047200.91134972
51Basal cell carcinoma_Homo sapiens_hsa052170.91010680
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.90939345
53Gastric acid secretion_Homo sapiens_hsa049710.88343017
54TGF-beta signaling pathway_Homo sapiens_hsa043500.86272478
55Cholinergic synapse_Homo sapiens_hsa047250.83836948
56Serotonergic synapse_Homo sapiens_hsa047260.82833455
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.82799267
58Sphingolipid signaling pathway_Homo sapiens_hsa040710.82753550
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81013979
60MAPK signaling pathway_Homo sapiens_hsa040100.80110207
61Ras signaling pathway_Homo sapiens_hsa040140.79251746
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78939213
63Salivary secretion_Homo sapiens_hsa049700.78562044
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75564990
65Calcium signaling pathway_Homo sapiens_hsa040200.75483995
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75115768
67Steroid biosynthesis_Homo sapiens_hsa001000.73152749
68VEGF signaling pathway_Homo sapiens_hsa043700.72844325
69ErbB signaling pathway_Homo sapiens_hsa040120.72279151
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70477565
71Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69612186
72Ovarian steroidogenesis_Homo sapiens_hsa049130.69587397
73Alcoholism_Homo sapiens_hsa050340.69185800
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69101120
75Wnt signaling pathway_Homo sapiens_hsa043100.68621463
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67491514
77Morphine addiction_Homo sapiens_hsa050320.67475219
78ECM-receptor interaction_Homo sapiens_hsa045120.64906504
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64158088
80FoxO signaling pathway_Homo sapiens_hsa040680.61117682
81Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61060162
82AMPK signaling pathway_Homo sapiens_hsa041520.59011982
83Glycerolipid metabolism_Homo sapiens_hsa005610.58657507
84Tight junction_Homo sapiens_hsa045300.57273342
85Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55190741
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54863475
87Ribosome_Homo sapiens_hsa030100.54824693
88Fatty acid biosynthesis_Homo sapiens_hsa000610.54822845
89Steroid hormone biosynthesis_Homo sapiens_hsa001400.53615069
90Glucagon signaling pathway_Homo sapiens_hsa049220.53024350
91MicroRNAs in cancer_Homo sapiens_hsa052060.51697447
92Glioma_Homo sapiens_hsa052140.50959514
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.50638892
94Cardiac muscle contraction_Homo sapiens_hsa042600.49394943
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48977353
96Tyrosine metabolism_Homo sapiens_hsa003500.48871439
97Rap1 signaling pathway_Homo sapiens_hsa040150.48840983
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47764537
99mTOR signaling pathway_Homo sapiens_hsa041500.47538254
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41363995

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