CCL23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine catabolic process (GO:0006216)7.43679339
2cytidine deamination (GO:0009972)7.43679339
3cytidine metabolic process (GO:0046087)7.43679339
4positive regulation of monocyte chemotaxis (GO:0090026)6.71402758
5eosinophil chemotaxis (GO:0048245)6.61226736
6regulation of chronic inflammatory response (GO:0002676)6.60595941
7pyrimidine ribonucleoside catabolic process (GO:0046133)6.59409447
8regulation of T cell tolerance induction (GO:0002664)6.48484496
9DNA deamination (GO:0045006)6.47897186
10regulation of activation of Janus kinase activity (GO:0010533)6.39739277
11regulation of mononuclear cell migration (GO:0071675)6.25794956
12regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450916.05718863
13eosinophil migration (GO:0072677)5.97622815
14positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)5.96598833
15positive regulation of natural killer cell mediated immunity (GO:0002717)5.84036236
16regulation of chemokine-mediated signaling pathway (GO:0070099)5.58539904
17regulation of macrophage chemotaxis (GO:0010758)5.53233566
18negative regulation of B cell proliferation (GO:0030889)5.51868057
19regulation of tolerance induction (GO:0002643)5.47780838
20regulation of regulatory T cell differentiation (GO:0045589)5.44249396
21regulation of T cell chemotaxis (GO:0010819)5.43618447
22positive regulation of T cell chemotaxis (GO:0010820)5.43618447
23negative regulation of organelle assembly (GO:1902116)5.41076391
24Arp2/3 complex-mediated actin nucleation (GO:0034314)5.26470284
25dendritic cell chemotaxis (GO:0002407)5.16803677
26positive regulation of tolerance induction (GO:0002645)5.08919627
27NIK/NF-kappaB signaling (GO:0038061)5.03849695
28regulation of natural killer cell mediated cytotoxicity (GO:0042269)5.02473726
29regulation of natural killer cell mediated immunity (GO:0002715)5.02473726
30macrophage chemotaxis (GO:0048246)5.00248322
31positive regulation of translational initiation (GO:0045948)4.79396599
32regulation of interleukin-2 biosynthetic process (GO:0045076)4.77694611
33regulation of monocyte chemotaxis (GO:0090025)4.76649322
34positive regulation of T cell apoptotic process (GO:0070234)4.66321095
35negative regulation of T cell apoptotic process (GO:0070233)4.49529638
36regulation of lymphocyte chemotaxis (GO:1901623)4.40185284
37* monocyte chemotaxis (GO:0002548)4.39136517
38actin nucleation (GO:0045010)4.29924018
39granulocyte activation (GO:0036230)4.22699838
40regulation of T cell migration (GO:2000404)4.16706145
41cellular response to interleukin-15 (GO:0071350)4.12385011
42regulation of leukocyte mediated cytotoxicity (GO:0001910)4.08931686
43response to interleukin-15 (GO:0070672)4.01717070
44positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.99865819
45positive regulation of leukocyte apoptotic process (GO:2000108)3.98814438
46positive regulation of protein sumoylation (GO:0033235)3.98067728
47nucleoside diphosphate catabolic process (GO:0009134)3.94221734
48dendritic cell migration (GO:0036336)3.93718808
49negative regulation by host of viral transcription (GO:0043922)3.89078594
50negative regulation of B cell activation (GO:0050869)3.87531624
51regulation of interleukin-12 biosynthetic process (GO:0045075)3.87345177
52neutrophil activation (GO:0042119)3.80628976
53positive regulation of lymphocyte apoptotic process (GO:0070230)3.79895120
54negative regulation of viral genome replication (GO:0045071)3.71421577
55positive regulation of T cell migration (GO:2000406)3.63940233
56positive regulation of lymphocyte migration (GO:2000403)3.59490246
57regulation of T cell apoptotic process (GO:0070232)3.56358889
58regulation of lymphocyte migration (GO:2000401)3.53423312
59regulation of cell killing (GO:0031341)3.51153911
60positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.49736648
61purine nucleoside diphosphate metabolic process (GO:0009135)3.48441587
62purine ribonucleoside diphosphate metabolic process (GO:0009179)3.48441587
63regulation of interleukin-8 biosynthetic process (GO:0045414)3.40212970
64intestinal epithelial cell development (GO:0060576)3.39774260
65positive regulation of cell killing (GO:0031343)3.37080869
66negative regulation of chemokine production (GO:0032682)3.35846570
67positive regulation of smooth muscle cell migration (GO:0014911)3.31262728
68positive regulation of calcium-mediated signaling (GO:0050850)3.25866118
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.24429743
70regulation of alpha-beta T cell proliferation (GO:0046640)3.24276089
71lipopolysaccharide-mediated signaling pathway (GO:0031663)3.23345005
72T cell costimulation (GO:0031295)3.23336413
73negative regulation of interleukin-12 production (GO:0032695)3.22682966
74lymphocyte costimulation (GO:0031294)3.18680026
75negative regulation of T cell differentiation (GO:0045581)3.12745988
76pyrimidine nucleoside catabolic process (GO:0046135)3.10303232
77negative regulation of cytokine biosynthetic process (GO:0042036)3.09650158
78negative regulation of T cell activation (GO:0050868)3.09087178
79negative regulation of lymphocyte apoptotic process (GO:0070229)3.03509922
80activated T cell proliferation (GO:0050798)2.98876507
81positive regulation of type 2 immune response (GO:0002830)2.97763535
82cellular defense response (GO:0006968)2.97194478
83negative regulation of interleukin-2 production (GO:0032703)2.97145082
84T cell migration (GO:0072678)2.93950910
85cellular response to exogenous dsRNA (GO:0071360)2.92793063
86negative regulation of T cell proliferation (GO:0042130)2.92068537
87regulation of T cell mediated cytotoxicity (GO:0001914)2.91700425
88positive thymic T cell selection (GO:0045059)2.91459949
89regulation of immunoglobulin secretion (GO:0051023)2.90316170
90positive regulation of interleukin-8 secretion (GO:2000484)2.88640305
91T cell mediated immunity (GO:0002456)2.87621001
92ribonucleoside diphosphate metabolic process (GO:0009185)2.86398561
93negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.85104378
94regulation of B cell receptor signaling pathway (GO:0050855)2.83415638
95chemokine-mediated signaling pathway (GO:0070098)2.82210022
96negative regulation of T cell receptor signaling pathway (GO:0050860)2.82120680
97negative regulation of leukocyte apoptotic process (GO:2000107)2.80334826
98positive regulation of hair follicle development (GO:0051798)2.79733749
99positive regulation of hair cycle (GO:0042635)2.79733749
100positive regulation of B cell differentiation (GO:0045579)2.76805088

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.00972353
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.66888691
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.21198571
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human5.00228595
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.32754344
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.17888275
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.16482148
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.07320541
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.81652088
10STAT4_19710469_ChIP-ChIP_TH1__Mouse3.23791926
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.67788216
12MYB_26560356_Chip-Seq_TH2_Human2.67252773
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.61554111
14RUNX_20019798_ChIP-Seq_JUKART_Human2.60165251
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.55358601
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.52008417
17GATA3_27048872_Chip-Seq_THYMUS_Human2.21258909
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.20525377
19* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.11612550
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03338975
21SPI1_23547873_ChIP-Seq_NB4_Human1.91817567
22MYB_26560356_Chip-Seq_TH1_Human1.89336683
23FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81235990
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.77581436
25TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73565999
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66073698
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65233414
28SPI1_23127762_ChIP-Seq_K562_Human1.65116279
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.65079174
30PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.63404368
31PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62898352
32SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58972921
33HTT_18923047_ChIP-ChIP_STHdh_Human1.55451886
34MAF_26560356_Chip-Seq_TH1_Human1.54086244
35MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48723782
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47731670
37MAF_26560356_Chip-Seq_TH2_Human1.44702384
38UTX_26944678_Chip-Seq_JUKART_Human1.41995797
39CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37144576
40VDR_24763502_ChIP-Seq_THP-1_Human1.35037142
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34552761
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30772548
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.25612607
44MYB_21317192_ChIP-Seq_ERMYB_Mouse1.24082850
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18247597
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.17280559
47CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17134226
48FLI1_21867929_ChIP-Seq_CD8_Mouse1.15612534
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14429724
50LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13815779
51CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11394239
52GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10806860
53RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06044099
54NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.04723941
55GATA3_26560356_Chip-Seq_TH2_Human1.04612557
56BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.04278532
57GATA1_22025678_ChIP-Seq_K562_Human1.02958134
58E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.02790326
59TAF2_19829295_ChIP-Seq_ESCs_Human1.01374737
60TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.99441138
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99418092
62DCP1A_22483619_ChIP-Seq_HELA_Human0.99163347
63TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.99009162
64BCOR_27268052_Chip-Seq_Bcells_Human0.98530246
65ELF1_20517297_ChIP-Seq_JURKAT_Human0.98311712
66KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97088120
67KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97088120
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97088120
69GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95895395
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95870225
71GATA3_21867929_ChIP-Seq_TH1_Mouse0.95569081
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94371822
73BCL6_27268052_Chip-Seq_Bcells_Human0.93235626
74RUNX1_22412390_ChIP-Seq_EML_Mouse0.92695784
75SMAD_19615063_ChIP-ChIP_OVARY_Human0.90507817
76VDR_23849224_ChIP-Seq_CD4+_Human0.88616231
77P300_27268052_Chip-Seq_Bcells_Human0.88489216
78VDR_24787735_ChIP-Seq_THP-1_Human0.88251623
79STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87655941
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.85569282
81GABP_17652178_ChIP-ChIP_JURKAT_Human0.82185470
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82119425
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81970918
84TRIM28_21343339_ChIP-Seq_HEK293_Human0.79390931
85JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79118993
86IKZF1_21737484_ChIP-ChIP_HCT116_Human0.78585510
87NOTCH1_21737748_ChIP-Seq_TLL_Human0.77840940
88PU.1_20513432_ChIP-Seq_Bcells_Mouse0.77195823
89ELF1_17652178_ChIP-ChIP_JURKAT_Human0.77023219
90SPI1_20517297_ChIP-Seq_HL60_Human0.76876635
91GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.76308301
92VDR_21846776_ChIP-Seq_THP-1_Human0.75265070
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.74519206
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.74454592
95NANOG_20526341_ChIP-Seq_ESCs_Human0.74404021
96PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.74178344
97GATA3_26560356_Chip-Seq_TH1_Human0.74166802
98GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.72816093
99IGF1R_20145208_ChIP-Seq_DFB_Human0.70763344
100TFEB_21752829_ChIP-Seq_HELA_Human0.69591108

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to5.65918468
2MP0001853_heart_inflammation3.83441007
3MP0001873_stomach_inflammation3.40319023
4MP0002148_abnormal_hypersensitivity_rea3.36903705
5MP0006082_CNS_inflammation3.31871263
6MP0009785_altered_susceptibility_to3.19785565
7MP0003045_fibrosis2.92545680
8MP0004145_abnormal_muscle_electrophysio2.84109854
9MP0010307_abnormal_tumor_latency2.67249544
10MP0001835_abnormal_antigen_presentation2.64594423
11MP0009333_abnormal_splenocyte_physiolog2.62907132
12MP0002877_abnormal_melanocyte_morpholog2.60330078
13MP0005000_abnormal_immune_tolerance2.50594607
14MP0003763_abnormal_thymus_physiology2.48916825
15MP0003191_abnormal_cellular_cholesterol2.47815458
16MP0005025_abnormal_response_to2.41527728
17MP0001800_abnormal_humoral_immune2.37599372
18MP0002723_abnormal_immune_serum2.37186351
19MP0002405_respiratory_system_inflammati2.33037839
20MP0002638_abnormal_pupillary_reflex2.21311622
21MP0003075_altered_response_to2.18304282
22MP0003436_decreased_susceptibility_to2.11596720
23MP0002419_abnormal_innate_immunity2.05247306
24MP0003011_delayed_dark_adaptation2.03923970
25MP0001790_abnormal_immune_system2.03114339
26MP0005387_immune_system_phenotype2.03114339
27MP0000685_abnormal_immune_system2.02839306
28MP0002420_abnormal_adaptive_immunity2.02414243
29MP0001819_abnormal_immune_cell2.02095737
30MP0002452_abnormal_antigen_presenting2.01158088
31MP0002139_abnormal_hepatobiliary_system1.93699028
32MP0005310_abnormal_salivary_gland1.87705946
33MP0001188_hyperpigmentation1.87658239
34MP0010155_abnormal_intestine_physiology1.80920430
35MP0000569_abnormal_digit_pigmentation1.71517470
36MP0001845_abnormal_inflammatory_respons1.68243075
37MP0009840_abnormal_foam_cell1.66528484
38MP0003303_peritoneal_inflammation1.64268532
39MP0001905_abnormal_dopamine_level1.63933094
40MP0009764_decreased_sensitivity_to1.63891204
41MP0002398_abnormal_bone_marrow1.61116117
42MP0000716_abnormal_immune_system1.59968557
43MP0005165_increased_susceptibility_to1.53868474
44MP0000689_abnormal_spleen_morphology1.41507552
45MP0003806_abnormal_nucleotide_metabolis1.39809187
46MP0005464_abnormal_platelet_physiology1.35452153
47MP0003448_altered_tumor_morphology1.34895240
48MP0000343_altered_response_to1.34601039
49MP0002429_abnormal_blood_cell1.29616471
50MP0002138_abnormal_hepatobiliary_system1.28959856
51MP0002090_abnormal_vision1.28211586
52MP0002722_abnormal_immune_system1.27800846
53MP0002933_joint_inflammation1.26546437
54MP0005058_abnormal_lysosome_morphology1.25651635
55MP0000920_abnormal_myelination1.24266526
56MP0008469_abnormal_protein_level1.23023086
57MP0009765_abnormal_xenobiotic_induced1.22207043
58MP0005365_abnormal_bile_salt1.17267693
59MP0003786_premature_aging1.13705086
60MP0002277_abnormal_respiratory_mucosa1.13505466
61MP0003724_increased_susceptibility_to1.13431412
62MP0009763_increased_sensitivity_to1.11564478
63MP0000703_abnormal_thymus_morphology1.11297711
64MP0003567_abnormal_fetal_cardiomyocyte1.09422352
65MP0003183_abnormal_peptide_metabolism1.07879795
66MP0008007_abnormal_cellular_replicative1.04209772
67MP0004947_skin_inflammation1.03329110
68MP0003866_abnormal_defecation1.03199674
69MP0005166_decreased_susceptibility_to0.98921927
70MP0001533_abnormal_skeleton_physiology0.98710473
71MP0000604_amyloidosis0.97302310
72MP0005623_abnormal_meninges_morphology0.94629615
73MP0005360_urolithiasis0.94104088
74MP0005174_abnormal_tail_pigmentation0.88481796
75MP0008004_abnormal_stomach_pH0.86096500
76MP0003172_abnormal_lysosome_physiology0.84847312
77MP0002168_other_aberrant_phenotype0.83559951
78MP0009278_abnormal_bone_marrow0.82478760
79MP0004381_abnormal_hair_follicle0.82411215
80MP0000371_diluted_coat_color0.82380046
81MP0002998_abnormal_bone_remodeling0.81276593
82MP0001663_abnormal_digestive_system0.78442556
83MP0001919_abnormal_reproductive_system0.71234346
84MP0005167_abnormal_blood-brain_barrier0.70199038
85MP0001968_abnormal_touch/_nociception0.70017314
86MP0008873_increased_physiological_sensi0.69722098
87MP0006035_abnormal_mitochondrial_morpho0.68136477
88MP0005164_abnormal_response_to0.61086327
89MP0009643_abnormal_urine_homeostasis0.60894877
90MP0003690_abnormal_glial_cell0.58477702
91MP0002019_abnormal_tumor_incidence0.58413535
92MP0000858_altered_metastatic_potential0.56713958
93MP0003137_abnormal_impulse_conducting0.55874026
94MP0002332_abnormal_exercise_endurance0.53893093
95MP0005075_abnormal_melanosome_morpholog0.51261801
96MP0001186_pigmentation_phenotype0.50487970
97MP0006054_spinal_hemorrhage0.49964067
98MP0005390_skeleton_phenotype0.49317941
99MP0002693_abnormal_pancreas_physiology0.49079856
100MP0002136_abnormal_kidney_physiology0.48602348

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.42444838
2Abnormality of T cell number (HP:0011839)6.45304708
3IgG deficiency (HP:0004315)4.52896110
4Recurrent cutaneous fungal infections (HP:0011370)4.41288033
5Chronic mucocutaneous candidiasis (HP:0002728)4.41288033
6Abnormality of the prostate (HP:0008775)4.20855742
7Severe combined immunodeficiency (HP:0004430)4.15130745
8Abnormality of T cells (HP:0002843)4.12095145
9Chronic obstructive pulmonary disease (HP:0006510)4.05475327
10Obstructive lung disease (HP:0006536)4.05475327
11Purpura (HP:0000979)4.05253354
12Stomatitis (HP:0010280)3.84377852
13Elevated erythrocyte sedimentation rate (HP:0003565)3.73538324
14Tongue fasciculations (HP:0001308)3.61118326
15Ureteral stenosis (HP:0000071)3.60369521
16Combined immunodeficiency (HP:0005387)3.58530180
17Prolonged neonatal jaundice (HP:0006579)3.57262321
18Thyroiditis (HP:0100646)3.39901775
19Meningitis (HP:0001287)3.39747572
20Recurrent bronchitis (HP:0002837)3.37924743
21Chronic diarrhea (HP:0002028)3.31371179
22Abnormality of glycolipid metabolism (HP:0010969)3.31032345
23Abnormality of liposaccharide metabolism (HP:0010968)3.31032345
24Abnormality of glycosphingolipid metabolism (HP:0004343)3.31032345
25Muscle fibrillation (HP:0010546)3.26534386
26Ureteral obstruction (HP:0006000)3.25179223
27Agammaglobulinemia (HP:0004432)3.23687138
28Gangrene (HP:0100758)3.22436808
29Hypoplasia of the thymus (HP:0000778)3.17184002
30Type I transferrin isoform profile (HP:0003642)3.15588327
31Hemoptysis (HP:0002105)3.12417940
32Abnormal delayed hypersensitivity skin test (HP:0002963)3.08312908
33Systemic lupus erythematosus (HP:0002725)3.07807184
34Encephalitis (HP:0002383)3.06208188
35Recurrent skin infections (HP:0001581)3.05384200
36Pulmonary infiltrates (HP:0002113)3.01922961
37Methylmalonic aciduria (HP:0012120)3.01682111
38Hemiplegia (HP:0002301)2.94123711
39Abnormality of the pleura (HP:0002103)2.89059423
40Abnormality of macrophages (HP:0004311)2.85357724
41Abnormal albumin level (HP:0012116)2.84446167
42Hypoalbuminemia (HP:0003073)2.84446167
43Agitation (HP:0000713)2.81577017
44Abnormality of lateral ventricle (HP:0030047)2.80505324
45Increased cerebral lipofuscin (HP:0011813)2.77930845
46Increased neuronal autofluorescent lipopigment (HP:0002074)2.77536928
47Cutaneous melanoma (HP:0012056)2.73815713
48Recurrent abscess formation (HP:0002722)2.71739808
49Vasculitis (HP:0002633)2.71667568
50Chest pain (HP:0100749)2.70464395
51Bifid tongue (HP:0010297)2.69365147
52Squamous cell carcinoma (HP:0002860)2.68494972
53Acute hepatic failure (HP:0006554)2.67305342
54Pulmonary embolism (HP:0002204)2.66437635
55Recurrent bacterial skin infections (HP:0005406)2.63434048
56Pulmonary fibrosis (HP:0002206)2.59439750
57Global brain atrophy (HP:0002283)2.55646434
58Increased IgM level (HP:0003496)2.54742508
59Leukocytosis (HP:0001974)2.54072496
60Recurrent fungal infections (HP:0002841)2.53276890
61Abnormality of the pericardium (HP:0001697)2.52294295
62Myositis (HP:0100614)2.46010504
63Abnormality of the anterior horn cell (HP:0006802)2.43817396
64Degeneration of anterior horn cells (HP:0002398)2.43817396
65Progressive external ophthalmoplegia (HP:0000590)2.43728803
66Recurrent viral infections (HP:0004429)2.43129589
67Polyneuropathy (HP:0001271)2.39990366
68Abnormality of midbrain morphology (HP:0002418)2.39452454
69Molar tooth sign on MRI (HP:0002419)2.39452454
70Hypoproteinemia (HP:0003075)2.36410457
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.35188320
72Abnormal protein N-linked glycosylation (HP:0012347)2.35188320
73Abnormal protein glycosylation (HP:0012346)2.35188320
74Abnormal glycosylation (HP:0012345)2.35188320
75Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.30525176
76Decreased activity of mitochondrial respiratory chain (HP:0008972)2.30525176
77Thrombocytosis (HP:0001894)2.29520965
78Abolished electroretinogram (ERG) (HP:0000550)2.25140602
79Pancreatitis (HP:0001733)2.25083996
80Skin rash (HP:0000988)2.24252232
81Glomerulopathy (HP:0100820)2.23949914
82Abnormality of male internal genitalia (HP:0000022)2.23774475
83Periodontitis (HP:0000704)2.22864581
84Abnormality of aromatic amino acid family metabolism (HP:0004338)2.22473747
85Periorbital edema (HP:0100539)2.18934455
86Malignant hyperthermia (HP:0002047)2.17396078
87Methylmalonic acidemia (HP:0002912)2.17036227
88Increased serum ferritin (HP:0003281)2.14942472
89Petechiae (HP:0000967)2.14717243
90Acrocyanosis (HP:0001063)2.12370227
91Mediastinal lymphadenopathy (HP:0100721)2.12029468
92Abnormality of eosinophils (HP:0001879)2.11365766
93Facial edema (HP:0000282)2.10685694
94Zonular cataract (HP:0010920)2.10344967
95Retrobulbar optic neuritis (HP:0100654)2.08809702
96Optic neuritis (HP:0100653)2.08809702
97Premature loss of primary teeth (HP:0006323)2.05128448
98Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.00125884
99Atrophy/Degeneration involving motor neurons (HP:0007373)1.98628688
100Joint swelling (HP:0001386)1.98223779

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK33.90494599
2FES3.48332953
3TYRO32.86232763
4KDR2.74509847
5TBK12.62591254
6BCKDK2.51218067
7SCYL22.50512796
8IKBKE2.04548901
9TXK11.0809125
10CSK1.97100422
11IRAK31.92639988
12IKBKB1.63840493
13BLK1.62057340
14JAK31.48329476
15PIK3CG1.48130308
16TESK21.44500384
17TNK21.42993167
18ZAP701.40617612
19GRK71.33838958
20LCK1.33048534
21ACVR1B1.26813803
22SYK1.25828251
23ITK1.25026123
24BUB11.25023934
25ADRBK21.23130646
26DAPK11.21239085
27MAP3K141.19016692
28MAPK71.18541866
29MAP4K11.13603858
30RIPK41.13478938
31CSF1R1.12886407
32FGR1.05232671
33JAK21.04408627
34PRKCQ1.03831010
35PDGFRB0.98409528
36LYN0.97691292
37LIMK10.91607237
38CAMKK20.91578335
39TLK10.91388592
40CAMK40.89649519
41IRAK40.77366062
42TESK10.69694749
43MINK10.68509206
44PIM10.67554287
45PRKD30.67235388
46MARK30.66482581
47BMPR20.66005527
48MATK0.65485150
49TEC0.65217663
50FYN0.61247756
51TAOK30.60352638
52VRK10.59202796
53VRK20.59155810
54TYK20.56822647
55CHUK0.56539177
56PRKCI0.55817047
57BTK0.55574689
58TGFBR20.53699826
59MST40.51235282
60GRK60.50018800
61ATR0.49445804
62CDK40.47891406
63PIM20.47525195
64CAMK2G0.41657955
65DDR20.41584625
66IRAK20.39887862
67NME20.39526593
68TAOK20.38562914
69CAMK2A0.35893295
70CDK190.32332788
71AURKA0.31960450
72ABL10.30199855
73ABL20.28508481
74PRKCG0.26123202
75INSR0.25997166
76CSNK1G30.24270387
77MAP2K60.24105012
78DYRK1B0.23929521
79MAPKAPK20.23551168
80CSNK1A1L0.22988205
81STK110.22559228
82CAMK1D0.22353091
83STK100.21852706
84MYLK0.21027200
85JAK10.17894388
86PBK0.17084211
87RIPK10.16643801
88HIPK20.16276415
89HCK0.15906226
90MAPK40.15454497
91DAPK30.15149832
92MAPK110.15063037
93MAP3K120.14843377
94SRC0.14788373
95IGF1R0.14035445
96CDC42BPA0.13578875
97FGFR10.13125048
98MAP3K90.13011011
99PAK10.12307235
100GRK10.12279272

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.78026964
2Autoimmune thyroid disease_Homo sapiens_hsa053204.22534112
3Graft-versus-host disease_Homo sapiens_hsa053323.73952172
4Cytosolic DNA-sensing pathway_Homo sapiens_hsa046233.71452831
5Allograft rejection_Homo sapiens_hsa053303.40806705
6Rheumatoid arthritis_Homo sapiens_hsa053233.20646820
7Antigen processing and presentation_Homo sapiens_hsa046123.11342557
8Type I diabetes mellitus_Homo sapiens_hsa049402.61752400
9Prion diseases_Homo sapiens_hsa050202.47286662
10NOD-like receptor signaling pathway_Homo sapiens_hsa046212.45553725
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.41640971
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.32678145
13Hematopoietic cell lineage_Homo sapiens_hsa046402.30813620
14T cell receptor signaling pathway_Homo sapiens_hsa046602.24338534
15Staphylococcus aureus infection_Homo sapiens_hsa051502.16850486
16Toll-like receptor signaling pathway_Homo sapiens_hsa046202.15364141
17Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.11501446
18Asthma_Homo sapiens_hsa053102.00134366
19Measles_Homo sapiens_hsa051621.92603788
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.87908489
21Viral myocarditis_Homo sapiens_hsa054161.85270004
22Leishmaniasis_Homo sapiens_hsa051401.75861107
23Osteoclast differentiation_Homo sapiens_hsa043801.53445820
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.47572393
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.46077860
26* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.38633565
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.28377964
28Folate biosynthesis_Homo sapiens_hsa007901.26385818
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.24212413
30Sulfur relay system_Homo sapiens_hsa041221.23891486
31Salmonella infection_Homo sapiens_hsa051321.11968327
32TNF signaling pathway_Homo sapiens_hsa046681.07660336
33Influenza A_Homo sapiens_hsa051641.07052371
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.04342340
35Herpes simplex infection_Homo sapiens_hsa051681.02303191
36Lysosome_Homo sapiens_hsa041421.00484746
37Malaria_Homo sapiens_hsa051440.96562301
38Shigellosis_Homo sapiens_hsa051310.96248368
39Pertussis_Homo sapiens_hsa051330.95668622
40* Chemokine signaling pathway_Homo sapiens_hsa040620.93368628
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92820642
42Tuberculosis_Homo sapiens_hsa051520.92618762
43Proteasome_Homo sapiens_hsa030500.89851418
44Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.81552393
45Tryptophan metabolism_Homo sapiens_hsa003800.80080667
46Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.72502988
47Legionellosis_Homo sapiens_hsa051340.69128313
48Primary bile acid biosynthesis_Homo sapiens_hsa001200.67873721
49Phagosome_Homo sapiens_hsa041450.67352871
50Other glycan degradation_Homo sapiens_hsa005110.66826452
51Epstein-Barr virus infection_Homo sapiens_hsa051690.65862359
52Systemic lupus erythematosus_Homo sapiens_hsa053220.63220069
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62832938
54Selenocompound metabolism_Homo sapiens_hsa004500.57998655
55Bladder cancer_Homo sapiens_hsa052190.57175763
56Regulation of autophagy_Homo sapiens_hsa041400.55162563
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55135357
58Homologous recombination_Homo sapiens_hsa034400.54361813
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54277144
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.50992434
61N-Glycan biosynthesis_Homo sapiens_hsa005100.47926155
62Toxoplasmosis_Homo sapiens_hsa051450.46915482
63Collecting duct acid secretion_Homo sapiens_hsa049660.44222578
64Renin-angiotensin system_Homo sapiens_hsa046140.41714385
65Apoptosis_Homo sapiens_hsa042100.40364951
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39806684
67Oxidative phosphorylation_Homo sapiens_hsa001900.38950036
68African trypanosomiasis_Homo sapiens_hsa051430.38870896
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38403820
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.37457519
71Fatty acid elongation_Homo sapiens_hsa000620.36187092
72Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34607852
73Endocytosis_Homo sapiens_hsa041440.34013905
74HTLV-I infection_Homo sapiens_hsa051660.33396882
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33210367
76Fatty acid degradation_Homo sapiens_hsa000710.31170726
77Non-small cell lung cancer_Homo sapiens_hsa052230.30046954
78Sulfur metabolism_Homo sapiens_hsa009200.29239926
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26483141
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.26429804
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.25256377
82Dorso-ventral axis formation_Homo sapiens_hsa043200.23282083
83Complement and coagulation cascades_Homo sapiens_hsa046100.23112325
84B cell receptor signaling pathway_Homo sapiens_hsa046620.22620115
85Phototransduction_Homo sapiens_hsa047440.22230704
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.21684773
87Caffeine metabolism_Homo sapiens_hsa002320.18110153
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16159237
89Galactose metabolism_Homo sapiens_hsa000520.16051825
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.12690818
91Hepatitis C_Homo sapiens_hsa051600.12568577
92Platelet activation_Homo sapiens_hsa046110.12426757
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.11473158
94Parkinsons disease_Homo sapiens_hsa050120.11370306
95Steroid hormone biosynthesis_Homo sapiens_hsa001400.10723594
96alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10472577
97Retinol metabolism_Homo sapiens_hsa008300.08792311
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.06394362
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.06280930
100Purine metabolism_Homo sapiens_hsa002300.05895400

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