CCL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis and atherosclerosis. It binds to chemokine receptors CCR2 and CCR4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1eosinophil chemotaxis (GO:0048245)8.08789037
2eosinophil migration (GO:0072677)7.10284534
3cellular response to ethanol (GO:0071361)5.84301920
4neutrophil activation involved in immune response (GO:0002283)5.68462905
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.63371537
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.63371537
7modulation by symbiont of host immune response (GO:0052553)5.63371537
8positive regulation by symbiont of host defense response (GO:0052509)5.63371537
9modulation by symbiont of host defense response (GO:0052031)5.63371537
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.63371537
11* monocyte chemotaxis (GO:0002548)5.04303758
12microglial cell activation (GO:0001774)4.64676118
13regulation of branching involved in salivary gland morphogenesis (GO:0060693)4.41415678
14glycosphingolipid catabolic process (GO:0046479)4.27309648
15positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.19781014
16positive regulation of lymphocyte migration (GO:2000403)4.08303613
17* regulation of lymphocyte chemotaxis (GO:1901623)4.08191417
18macrophage activation involved in immune response (GO:0002281)4.07421682
19pinocytosis (GO:0006907)3.97708637
20regulation of vitamin metabolic process (GO:0030656)3.94247857
21response to peptidoglycan (GO:0032494)3.92351811
22glycolipid catabolic process (GO:0019377)3.92032307
23positive regulation of macrophage differentiation (GO:0045651)3.90974614
24positive regulation of monocyte chemotaxis (GO:0090026)3.83872945
25oligosaccharide catabolic process (GO:0009313)3.81919382
26* regulation of mononuclear cell migration (GO:0071675)3.78593797
27positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.74507176
28regulation of chemokine biosynthetic process (GO:0045073)3.72423274
29negative regulation of myeloid cell apoptotic process (GO:0033033)3.63599185
30macrophage activation (GO:0042116)3.62072816
31positive regulation of heat generation (GO:0031652)3.58545139
32* lipopolysaccharide-mediated signaling pathway (GO:0031663)3.56340771
33granulocyte activation (GO:0036230)3.54669067
34positive regulation of interferon-alpha production (GO:0032727)3.53646921
35negative regulation of nitric oxide biosynthetic process (GO:0045019)3.53048237
36regulation of fever generation (GO:0031620)3.48132758
37regulation of interferon-alpha production (GO:0032647)3.47839283
38response to muramyl dipeptide (GO:0032495)3.45827407
39positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.44910180
40* regulation of lymphocyte migration (GO:2000401)3.44890111
41positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.43220991
42NIK/NF-kappaB signaling (GO:0038061)3.40682726
43response to host immune response (GO:0052572)3.40181791
44response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.40181791
45cyclooxygenase pathway (GO:0019371)3.39348454
46ceramide catabolic process (GO:0046514)3.39063222
47regulation of monocyte chemotaxis (GO:0090025)3.39029787
48cellular response to zinc ion (GO:0071294)3.37578512
49decidualization (GO:0046697)3.37300154
50T-helper 1 type immune response (GO:0042088)3.33900447
51regulation of membrane protein ectodomain proteolysis (GO:0051043)3.28480871
52cellular response to thyroid hormone stimulus (GO:0097067)3.28124933
53myeloid cell activation involved in immune response (GO:0002275)3.27290502
54membrane lipid catabolic process (GO:0046466)3.26408658
55neutrophil activation (GO:0042119)3.24571307
56myeloid dendritic cell differentiation (GO:0043011)3.23598450
57barbed-end actin filament capping (GO:0051016)3.23323484
58antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.22696977
59negative regulation of smooth muscle cell differentiation (GO:0051151)3.22610785
60phagocytosis, engulfment (GO:0006911)3.21588841
61regulation of cholesterol storage (GO:0010885)3.20490165
62* regulation of macrophage chemotaxis (GO:0010758)3.17193072
63regulation of interleukin-8 biosynthetic process (GO:0045414)3.10743225
64negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.10338026
65ribosomal small subunit biogenesis (GO:0042274)3.10047829
66positive regulation of NF-kappaB import into nucleus (GO:0042346)3.09061792
67detection of molecule of bacterial origin (GO:0032490)3.08816809
68response to laminar fluid shear stress (GO:0034616)3.08539418
69positive regulation of type 2 immune response (GO:0002830)3.08119723
70* cellular response to lipopolysaccharide (GO:0071222)3.04569867
71regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.03743898
72* granulocyte chemotaxis (GO:0071621)3.02887450
73response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.02183121
74response to host (GO:0075136)3.02183121
75response to host defenses (GO:0052200)3.02183121
76regulation of interferon-beta biosynthetic process (GO:0045357)3.00439257
77respiratory burst (GO:0045730)2.98112796
78positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.97947472
79interferon-gamma-mediated signaling pathway (GO:0060333)2.97799454
80amino sugar catabolic process (GO:0046348)2.96899577
81positive regulation of acute inflammatory response (GO:0002675)2.96866961
82positive regulation of macrophage cytokine production (GO:0060907)2.96356268
83cellular response to cadmium ion (GO:0071276)2.96269005
84myeloid cell homeostasis (GO:0002262)2.95277452
85* cellular response to molecule of bacterial origin (GO:0071219)2.94120084
86positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.94035182
87positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.93967259
88regulation of nitric oxide biosynthetic process (GO:0045428)2.93678299
89sphingolipid catabolic process (GO:0030149)2.93220956
90negative regulation of cytokine production involved in immune response (GO:0002719)2.92028776
91immunoglobulin mediated immune response (GO:0016064)2.91122522
92regulation of dendritic cell antigen processing and presentation (GO:0002604)2.90906094
93regulation of T-helper 2 cell differentiation (GO:0045628)2.87957588
94* granulocyte migration (GO:0097530)2.87850622
95positive regulation of gamma-delta T cell activation (GO:0046645)2.87766228
96adhesion of symbiont to host cell (GO:0044650)2.87227217
97virion attachment to host cell (GO:0019062)2.87227217
98positive regulation of chemokine secretion (GO:0090197)2.85949775
99apoptotic cell clearance (GO:0043277)2.84813463
100positive regulation of chemokine biosynthetic process (GO:0045080)2.84637945
101germinal center formation (GO:0002467)2.82709463
102positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.82562586
103positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.81260700
104cell adhesion mediated by integrin (GO:0033627)2.79722962
105myeloid dendritic cell activation (GO:0001773)2.79204682
106* lymphocyte chemotaxis (GO:0048247)2.78353952
107response to protozoan (GO:0001562)2.78272594
108regulation of cytokine secretion involved in immune response (GO:0002739)2.75666429
109protein localization to endosome (GO:0036010)2.74981246
110* positive regulation of leukocyte chemotaxis (GO:0002690)2.74695772
111cellular response to arsenic-containing substance (GO:0071243)2.74390151
112positive regulation of interleukin-6 production (GO:0032755)2.74366719
113positive regulation of nitric oxide biosynthetic process (GO:0045429)2.73455341
114I-kappaB phosphorylation (GO:0007252)2.71905005
115dendritic cell differentiation (GO:0097028)2.71366474
116mesenchymal-epithelial cell signaling (GO:0060638)2.70361437
117* positive regulation of leukocyte migration (GO:0002687)2.70252195
118fat-soluble vitamin biosynthetic process (GO:0042362)2.69358893
119phagosome maturation (GO:0090382)2.68913545
120regulation of interleukin-6 biosynthetic process (GO:0045408)2.67889591
121positive regulation of cellular amide metabolic process (GO:0034250)2.67648535
122response to manganese ion (GO:0010042)2.66142950
123regulation of macrophage cytokine production (GO:0010935)2.66067511
124macrophage differentiation (GO:0030225)2.64854478
125ribosomal small subunit assembly (GO:0000028)2.64038629
126myeloid leukocyte activation (GO:0002274)2.63659963
127hydrogen peroxide biosynthetic process (GO:0050665)2.63335351
128regulation of heat generation (GO:0031650)2.62701179
129* neutrophil chemotaxis (GO:0030593)2.62649751
130positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.61818831
131regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.61027781
132positive regulation of leukocyte degranulation (GO:0043302)2.60670259
133response to thyroid hormone (GO:0097066)2.60246121
134negative regulation of lipid storage (GO:0010888)2.60163733
135positive regulation of astrocyte differentiation (GO:0048711)2.60157256
136positive regulation vascular endothelial growth factor production (GO:0010575)2.59454361
137regulation of macrophage differentiation (GO:0045649)2.58838852
138mRNA transcription (GO:0009299)2.58411967
139tyrosine phosphorylation of STAT protein (GO:0007260)2.58259622
140positive regulation of toll-like receptor signaling pathway (GO:0034123)2.57022720
141positive regulation of antigen processing and presentation (GO:0002579)2.56292185
142regulation of podosome assembly (GO:0071801)2.55149524
143* regulation of leukocyte chemotaxis (GO:0002688)2.54275381
144wound healing, spreading of epidermal cells (GO:0035313)2.53618031
145positive regulation of mast cell degranulation (GO:0043306)2.53247968
146positive regulation of mast cell activation involved in immune response (GO:0033008)2.53247968
147response to interferon-alpha (GO:0035455)2.52837048
148regulation of heterotypic cell-cell adhesion (GO:0034114)2.50464746
149regulation of vitamin D biosynthetic process (GO:0060556)2.50132795
150positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.49010938
151negative regulation of interleukin-12 production (GO:0032695)2.48543955
152regulation of T-helper 1 cell differentiation (GO:0045625)2.47524304
153negative regulation of mast cell activation (GO:0033004)2.47214767

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.50384352
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.09118011
3TRIM28_21343339_ChIP-Seq_HEK293_Human4.22907161
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.98545185
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.80906862
6* IRF8_27001747_Chip-Seq_BMDM_Mouse3.72790624
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.41466888
8* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.28759403
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.16861660
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.13517234
11* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.12381610
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.81478435
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.69198979
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.55511384
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.52524418
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.47505846
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.44730838
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.43322295
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.43279236
20VDR_24787735_ChIP-Seq_THP-1_Human2.30580860
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.02924411
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.99916736
23GATA1_22025678_ChIP-Seq_K562_Human1.91874643
24KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.85939839
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.85939839
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.85939839
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.85027306
28* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.83028733
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82007454
30* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.80345178
31NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.78874101
32NRF2_20460467_ChIP-Seq_MEFs_Mouse1.78874101
33CJUN_26792858_Chip-Seq_BT549_Human1.77147095
34* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.76579628
35PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.76365199
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.75999489
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.75713505
38VDR_24763502_ChIP-Seq_THP-1_Human1.71635235
39* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.68854334
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66382035
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.64406968
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.53181477
43EGR1_19032775_ChIP-ChIP_M12_Human1.51593281
44RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49331200
45* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.48718463
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.48474542
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.47943903
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47838966
49* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.47006947
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44840621
51MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41903807
52SCL_19346495_ChIP-Seq_HPC-7_Human1.41525850
53* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.41145680
54CLOCK_20551151_ChIP-Seq_293T_Human1.39575932
55* PU_27001747_Chip-Seq_BMDM_Mouse1.38672357
56CDX2_19796622_ChIP-Seq_MESCs_Mouse1.37318320
57SOX2_20726797_ChIP-Seq_SW620_Human1.36530140
58* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36102957
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35999232
60* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34813658
61CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.31471345
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31209296
63* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.25338758
64* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.25338758
65BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24176697
66TFEB_21752829_ChIP-Seq_HELA_Human1.22440354
67SPI1_23547873_ChIP-Seq_NB4_Human1.21677200
68* LXR_22292898_ChIP-Seq_THP-1_Human1.19315341
69JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18515405
70* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18324843
71* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.18257634
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16492591
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.15419203
74RUNX_20019798_ChIP-Seq_JUKART_Human1.14066190
75CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13411307
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13212237
77ELK3_25401928_ChIP-Seq_HUVEC_Human1.12666564
78JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11662199
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.09613075
80FOXO3_23340844_ChIP-Seq_DLD1_Human1.08845395
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08732032
82E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08687761
83PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07965758
84THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07500124
85HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07061244
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06820570
87CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05488166
88TP53_18474530_ChIP-ChIP_U2OS_Human1.05438110
89RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04964987
90SPI1_23127762_ChIP-Seq_K562_Human1.04641640
91VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03455001
92CDX2_20551321_ChIP-Seq_CACO-2_Human1.03294020
93STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.03289710
94FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.02534431
95NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02300089
96GATA1_19941826_ChIP-Seq_K562_Human1.01412241
97* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00256007
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99243734
99STAT1_20625510_ChIP-Seq_HELA_Human0.98017026
100ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.96689101
101GATA1_19941827_ChIP-Seq_MEL_Mouse0.96068801
102PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95207888
103TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95018793
104MAF_26560356_Chip-Seq_TH1_Human0.94066525
105ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.93478685
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93398168
107LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.91947432
108RUNX1_22412390_ChIP-Seq_EML_Mouse0.91541029
109RXR_22158963_ChIP-Seq_LIVER_Mouse0.91513233
110LXR_22158963_ChIP-Seq_LIVER_Mouse0.91092368
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90204609
112P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89492418
113ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89197127
114TP53_16413492_ChIP-PET_HCT116_Human0.88961684
115* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.87243390
116VDR_21846776_ChIP-Seq_THP-1_Human0.85008531
117FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.84579530
118BRD4_25478319_ChIP-Seq_HGPS_Human0.84430197
119ESR2_21235772_ChIP-Seq_MCF-7_Human0.84303253
120SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.84214150
121MYB_26560356_Chip-Seq_TH2_Human0.84154716
122ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84120017
123SALL4_18804426_ChIP-ChIP_XEN_Mouse0.83990607
124* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.83692794
125GATA2_22383799_ChIP-Seq_G1ME_Mouse0.83451829
126FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83178482
127UBF1/2_26484160_Chip-Seq_HMECs_Human0.80052627
128STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.77100436
129KDM2B_26808549_Chip-Seq_DND41_Human0.75777444

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.10091970
2MP0008438_abnormal_cutaneous_collagen4.02615647
3MP0003303_peritoneal_inflammation3.52427138
4* MP0002148_abnormal_hypersensitivity_rea3.50176995
5MP0003195_calcinosis3.44770470
6MP0002139_abnormal_hepatobiliary_system2.93087258
7MP0005058_abnormal_lysosome_morphology2.89813952
8MP0006082_CNS_inflammation2.78430018
9* MP0009785_altered_susceptibility_to2.76228241
10MP0000372_irregular_coat_pigmentation2.68147919
11MP0005167_abnormal_blood-brain_barrier2.56115579
12* MP0000343_altered_response_to2.54950336
13* MP0002419_abnormal_innate_immunity2.53848575
14* MP0005000_abnormal_immune_tolerance2.50774527
15MP0001533_abnormal_skeleton_physiology2.50228375
16MP0001835_abnormal_antigen_presentation2.43324937
17MP0005076_abnormal_cell_differentiation2.41291251
18MP0003705_abnormal_hypodermis_morpholog2.20777416
19* MP0005023_abnormal_wound_healing2.12496104
20MP0003279_aneurysm2.03876304
21MP0008004_abnormal_stomach_pH1.99517617
22* MP0005025_abnormal_response_to1.98028460
23MP0005275_abnormal_skin_tensile1.96916767
24MP0003724_increased_susceptibility_to1.95916496
25MP0004510_myositis1.95666376
26MP0005257_abnormal_intraocular_pressure1.94960219
27MP0003075_altered_response_to1.84486384
28MP0005387_immune_system_phenotype1.83755432
29MP0001790_abnormal_immune_system1.83755432
30* MP0002452_abnormal_antigen_presenting1.83290584
31MP0002998_abnormal_bone_remodeling1.82141123
32MP0010352_gastrointestinal_tract_polyps1.79283800
33MP0003806_abnormal_nucleotide_metabolis1.78146637
34MP0005390_skeleton_phenotype1.76531974
35MP0003448_altered_tumor_morphology1.70220162
36MP0005503_abnormal_tendon_morphology1.67319021
37* MP0002723_abnormal_immune_serum1.65793359
38* MP0009764_decreased_sensitivity_to1.63982816
39MP0005171_absent_coat_pigmentation1.63662998
40MP0005166_decreased_susceptibility_to1.59833320
41MP0004947_skin_inflammation1.58559907
42MP0001958_emphysema1.56405052
43MP0003300_gastrointestinal_ulcer1.55696145
44* MP0005164_abnormal_response_to1.53712645
45* MP0001800_abnormal_humoral_immune1.49110162
46* MP0001845_abnormal_inflammatory_respons1.48999045
47MP0001853_heart_inflammation1.48886993
48MP0003172_abnormal_lysosome_physiology1.47298545
49MP0002295_abnormal_pulmonary_circulatio1.43587614
50MP0000604_amyloidosis1.42153702
51MP0009384_cardiac_valve_regurgitation1.41040162
52MP0002405_respiratory_system_inflammati1.40148905
53MP0010155_abnormal_intestine_physiology1.40033333
54MP0005671_abnormal_response_to1.38783125
55* MP0008469_abnormal_protein_level1.38682528
56MP0005451_abnormal_body_composition1.34427374
57MP0003656_abnormal_erythrocyte_physiolo1.33525767
58* MP0001819_abnormal_immune_cell1.30475911
59MP0003191_abnormal_cellular_cholesterol1.29834700
60MP0003828_pulmonary_edema1.29531130
61* MP0002420_abnormal_adaptive_immunity1.29035521
62MP0003329_amyloid_beta_deposits1.28313618
63* MP0003690_abnormal_glial_cell1.26839662
64MP0002933_joint_inflammation1.24118542
65MP0002138_abnormal_hepatobiliary_system1.21431052
66MP0003950_abnormal_plasma_membrane1.20242079
67MP0003091_abnormal_cell_migration1.18493987
68* MP0000249_abnormal_blood_vessel1.18492031
69MP0005464_abnormal_platelet_physiology1.18253676
70MP0005508_abnormal_skeleton_morphology1.14364476
71MP0000858_altered_metastatic_potential1.12060941
72MP0002877_abnormal_melanocyte_morpholog1.09051207
73MP0004883_abnormal_blood_vessel1.08080723
74* MP0003795_abnormal_bone_structure1.06782389
75MP0009278_abnormal_bone_marrow1.06496655
76* MP0009840_abnormal_foam_cell1.04471104
77MP0009333_abnormal_splenocyte_physiolog1.03859766
78MP0003186_abnormal_redox_activity1.02366060
79MP0001542_abnormal_bone_strength0.99512144
80MP0002837_dystrophic_cardiac_calcinosis0.98764324
81MP0001243_abnormal_dermal_layer0.97576997
82MP0003453_abnormal_keratinocyte_physiol0.97237384
83MP0005623_abnormal_meninges_morphology0.97184225
84MP0002254_reproductive_system_inflammat0.95617924
85MP0010368_abnormal_lymphatic_system0.94283011
86MP0005165_increased_susceptibility_to0.92830041
87MP0002332_abnormal_exercise_endurance0.92549061
88MP0009763_increased_sensitivity_to0.91932962
89MP0001727_abnormal_embryo_implantation0.88366838
90MP0000371_diluted_coat_color0.85717599
91MP0008873_increased_physiological_sensi0.85287606
92MP0005310_abnormal_salivary_gland0.84771927
93MP0005365_abnormal_bile_salt0.83957351
94MP0001299_abnormal_eye_distance/0.83583393
95MP0000685_abnormal_immune_system0.82220926
96MP0002277_abnormal_respiratory_mucosa0.82078030
97MP0002168_other_aberrant_phenotype0.81682924
98* MP0005197_abnormal_uvea_morphology0.81102615
99MP0008260_abnormal_autophagy0.77850851
100MP0006054_spinal_hemorrhage0.77646482
101MP0001851_eye_inflammation0.76744666
102MP0010307_abnormal_tumor_latency0.75706627
103* MP0005595_abnormal_vascular_smooth0.74893827
104* MP0000716_abnormal_immune_system0.74366439
105MP0000767_abnormal_smooth_muscle0.73575000
106MP0001663_abnormal_digestive_system0.73548820
107MP0003634_abnormal_glial_cell0.73517518
108MP0001849_ear_inflammation0.72825073
109MP0004272_abnormal_basement_membrane0.71985976
110MP0001545_abnormal_hematopoietic_system0.70940567
111MP0005397_hematopoietic_system_phenotyp0.70940567
112MP0000689_abnormal_spleen_morphology0.70659122
113* MP0002429_abnormal_blood_cell0.67026145
114MP0002060_abnormal_skin_morphology0.67003343
115MP0000465_gastrointestinal_hemorrhage0.66016720
116MP0003566_abnormal_cell_adhesion0.65959129
117MP0002896_abnormal_bone_mineralization0.65374817
118* MP0000920_abnormal_myelination0.64951477
119MP0002133_abnormal_respiratory_system0.64342045
120MP0005647_abnormal_sex_gland0.64216511
121MP0002090_abnormal_vision0.59324203
122MP0010386_abnormal_urinary_bladder0.58751144
123* MP0009765_abnormal_xenobiotic_induced0.58102561
124MP0002398_abnormal_bone_marrow0.57845308
125MP0005319_abnormal_enzyme/_coenzyme0.57766528

Predicted human phenotypes

RankGene SetZ-score
1Axonal loss (HP:0003447)5.90203598
2Recurrent abscess formation (HP:0002722)5.02355988
3Systemic lupus erythematosus (HP:0002725)5.00404886
4Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.52022765
5Loss of speech (HP:0002371)4.39558581
6Recurrent bacterial skin infections (HP:0005406)4.26402936
7Increased density of long bones (HP:0006392)4.18288303
8Neurofibrillary tangles (HP:0002185)4.13061933
9Mutism (HP:0002300)4.03848894
10Increased neuronal autofluorescent lipopigment (HP:0002074)3.86563075
11Increased cerebral lipofuscin (HP:0011813)3.86239928
12Premature rupture of membranes (HP:0001788)3.81733854
13Eczematoid dermatitis (HP:0000976)3.73838972
14Protrusio acetabuli (HP:0003179)3.63043308
15Vertebral compression fractures (HP:0002953)3.60994136
16Nuclear cataract (HP:0100018)3.55843214
17Wrist flexion contracture (HP:0001239)3.44037820
18Glomerulonephritis (HP:0000099)3.35414064
19Autoimmune thrombocytopenia (HP:0001973)3.19851850
20Abnormality of the vasculature of the conjunctiva (HP:0008054)3.13619850
21Osteolytic defects of the phalanges of the hand (HP:0009771)3.10844235
22Osteolytic defects of the hand bones (HP:0009699)3.10844235
23Pathologic fracture (HP:0002756)3.10566017
24Recurrent gram-negative bacterial infections (HP:0005420)3.10282003
25Dysostosis multiplex (HP:0000943)3.09140072
26Soft skin (HP:0000977)3.08095842
27Disinhibition (HP:0000734)3.06866755
28Mesomelia (HP:0003027)3.05369181
29Vacuolated lymphocytes (HP:0001922)3.00701914
30Metaphyseal irregularity (HP:0003025)2.94780997
31Hypoplastic ischia (HP:0003175)2.92384699
32Cerebral inclusion bodies (HP:0100314)2.92332167
33Abnormality of complement system (HP:0005339)2.91580972
34Spontaneous hematomas (HP:0007420)2.91315733
35Peritonitis (HP:0002586)2.89407077
36Apathy (HP:0000741)2.86615095
37Abnormality of macrophages (HP:0004311)2.85729672
38Diminished motivation (HP:0000745)2.85119698
39Cervical subluxation (HP:0003308)2.81915653
40Poor head control (HP:0002421)2.81053758
41Prostate neoplasm (HP:0100787)2.81037642
42Reticulocytopenia (HP:0001896)2.80873895
43Complement deficiency (HP:0004431)2.75087725
44Fragile skin (HP:0001030)2.73790943
45Basal ganglia calcification (HP:0002135)2.64490654
46Atrophic scars (HP:0001075)2.61408438
47Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.58478044
48Pustule (HP:0200039)2.58028735
49J-shaped sella turcica (HP:0002680)2.56580438
50Elevated erythrocyte sedimentation rate (HP:0003565)2.53673768
51Long clavicles (HP:0000890)2.52888068
52Malnutrition (HP:0004395)2.51060029
53Neuronal loss in central nervous system (HP:0002529)2.50062791
54Optic neuritis (HP:0100653)2.49773206
55Abnormality of the ischium (HP:0003174)2.49145091
56Fibular aplasia (HP:0002990)2.47896395
57Obstructive lung disease (HP:0006536)2.46345723
58Chronic obstructive pulmonary disease (HP:0006510)2.46345723
59Myositis (HP:0100614)2.45371042
60Orchitis (HP:0100796)2.44832285
61Cerebral aneurysm (HP:0004944)2.44124904
62Sparse lateral eyebrow (HP:0005338)2.43379467
63Mediastinal lymphadenopathy (HP:0100721)2.43062111
64Myocardial infarction (HP:0001658)2.42143508
65Progressive neurologic deterioration (HP:0002344)2.40815303
66Inappropriate behavior (HP:0000719)2.40778179
67Chin dimple (HP:0010751)2.39190182
68Arterial tortuosity (HP:0005116)2.39068369
69Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.38465062
70Abnormality of liposaccharide metabolism (HP:0010968)2.38342207
71Abnormality of glycosphingolipid metabolism (HP:0004343)2.38342207
72Abnormality of glycolipid metabolism (HP:0010969)2.38342207
73Vascular tortuosity (HP:0004948)2.37760328
74Prolonged neonatal jaundice (HP:0006579)2.34593205
75Conjunctival telangiectasia (HP:0000524)2.33648810
76Upper motor neuron abnormality (HP:0002127)2.32620678
77Amyloidosis (HP:0011034)2.32449417
78Recurrent skin infections (HP:0001581)2.31886936
79Gingivitis (HP:0000230)2.31516933
80Osteomyelitis (HP:0002754)2.30346130
81Aortic dissection (HP:0002647)2.29434420
82Dilatation of the ascending aorta (HP:0005111)2.29398752
83Purpura (HP:0000979)2.27731165
84Abnormality of iron homeostasis (HP:0011031)2.27645480
85Bone pain (HP:0002653)2.27464506
86Petechiae (HP:0000967)2.26446098
87Abnormal number of erythroid precursors (HP:0012131)2.23796067
88Biconcave vertebral bodies (HP:0004586)2.22208607
89Spondylolisthesis (HP:0003302)2.21854430
90Abnormality of cells of the erythroid lineage (HP:0012130)2.18911717
91Mucopolysacchariduria (HP:0008155)2.17981080
92Urinary glycosaminoglycan excretion (HP:0003541)2.17981080
93Asymmetric septal hypertrophy (HP:0001670)2.17218992
94Microglossia (HP:0000171)2.15251822
95Absent eyelashes (HP:0000561)2.13084614
96Dementia (HP:0000726)2.12516462
97Nephritis (HP:0000123)2.12337933
98Joint hemorrhage (HP:0005261)2.11823477
99Thick nail (HP:0001805)2.11432485
100Hepatosplenomegaly (HP:0001433)2.11368821
101Nausea (HP:0002018)2.09728431
102Pulmonary infiltrates (HP:0002113)2.07442701
103Premature loss of primary teeth (HP:0006323)2.07396484
104Abnormality of the periventricular white matter (HP:0002518)2.06513226
105Retinal atrophy (HP:0001105)2.05527830
106Supranuclear gaze palsy (HP:0000605)2.03666613
107Hemoptysis (HP:0002105)2.03655892
108Stomatitis (HP:0010280)2.02924754
109Tetraparesis (HP:0002273)2.02913289
110Periodontitis (HP:0000704)2.02524592
111Decreased subcutaneous fat (HP:0001002)2.01024576
112Aortic aneurysm (HP:0004942)1.98804618
113Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.98584564
114Agnosia (HP:0010524)1.97251923
115Blue sclerae (HP:0000592)1.96610596
116Alopecia of scalp (HP:0002293)1.95963152
117Increased serum ferritin (HP:0003281)1.95423426
118Ovoid vertebral bodies (HP:0003300)1.92712936
119Wormian bones (HP:0002645)1.91817734
120Bell-shaped thorax (HP:0001591)1.90757214
121Recurrent fungal infections (HP:0002841)1.90166063
122Acrocyanosis (HP:0001063)1.89938418
123Absent phalangeal crease (HP:0006109)1.89889437
124Hematochezia (HP:0002573)1.89756487
125Xanthomatosis (HP:0000991)1.89397033
126Interstitial pulmonary disease (HP:0006530)1.85102567
127Hydroxyprolinuria (HP:0003080)1.83120928
128Abnormality of proline metabolism (HP:0010907)1.83120928
129Increased CSF protein (HP:0002922)1.82290559
130Abnormality of polysaccharide metabolism (HP:0011012)1.82278239
131Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82278239
132Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82278239
133Diplopia (HP:0000651)1.82198473
134Abnormality of binocular vision (HP:0011514)1.82198473
135Thin bony cortex (HP:0002753)1.81176944
136Broad face (HP:0000283)1.81164598
137Abnormality of transition element cation homeostasis (HP:0011030)1.80823650
138Personality changes (HP:0000751)1.80790085
139Abnormality of the pericardium (HP:0001697)1.79874312
140Bruising susceptibility (HP:0000978)1.78745297
141Zonular cataract (HP:0010920)1.78088737
142Retrobulbar optic neuritis (HP:0100654)1.78035421
143Progressive visual loss (HP:0000529)1.76940096
144Esophageal varix (HP:0002040)1.76540652
145Polyneuropathy (HP:0001271)1.74684038
146Recurrent viral infections (HP:0004429)1.73774370
147Protuberant abdomen (HP:0001538)1.70781275
148Peripheral demyelination (HP:0011096)1.68717150
149Restrictive lung disease (HP:0002091)1.68691063
150Cardiomegaly (HP:0001640)1.67918059
151Joint stiffness (HP:0001387)1.67603751
152Abnormality of the nasal mucosa (HP:0000433)1.67522613
153Mucosal telangiectasiae (HP:0100579)1.65326271
154Recurrent pneumonia (HP:0006532)1.63797342
155Keratoconjunctivitis sicca (HP:0001097)1.63255535
156Vasculitis (HP:0002633)1.63026812

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.89460341
2BLK4.36891209
3SCYL23.83846507
4NME23.73976924
5MOS3.58253036
6TBK12.98179077
7PIM22.84687077
8TGFBR22.57808342
9ERN12.41072775
10MAP3K32.40923671
11TYK22.19370809
12TAOK22.16486648
13BMX2.08052675
14IKBKB1.98731499
15KIT1.98628542
16DDR21.93158459
17IKBKE1.91693554
18ACVR1B1.79483298
19NEK91.77279018
20CDC42BPA1.69818584
21ADRBK21.54255906
22FES1.49471320
23ABL21.46172075
24TAOK11.41193575
25GRK71.40354698
26EIF2AK21.34036181
27EPHB11.30626456
28CHUK1.29591270
29LATS21.24938360
30TRPM71.21464081
31CAMKK21.20164316
32MAP2K31.20106866
33PRPF4B1.17239887
34IRAK31.15430133
35CSK1.14220940
36PAK21.14209244
37IRAK41.12854495
38ERBB31.12749794
39ARAF1.11853641
40TTN1.11122876
41MAP3K131.11102420
42LMTK21.08551717
43TEC1.08385941
44RIPK41.08104103
45PAK61.06776174
46MATK1.04828055
47HCK1.02280200
48JAK11.02277099
49LYN1.00906094
50TYRO30.97080122
51TXK0.96256394
52MAP3K90.90689763
53STK100.86974256
54ABL10.83934195
55BMPR20.82250773
56ITK0.80121704
57PTK2B0.79288374
58PBK0.79092685
59CAMK1D0.78134073
60TESK10.77296190
61DAPK30.77118673
62JAK30.76957108
63LIMK10.76202709
64STK240.74327656
65MAP2K20.73739007
66TGFBR10.73349920
67MAPK40.72403488
68PRKCD0.72264469
69PIM10.71100648
70MAP3K50.69491405
71SYK0.66733954
72EPHB20.66595931
73EGFR0.66054275
74LCK0.66009810
75CASK0.64487797
76MAP4K10.64183923
77RIPK10.63213910
78ZAP700.62399312
79MST1R0.61108171
80FGR0.60767654
81PDGFRB0.58907136
82GSK3A0.58770880
83MKNK10.57898888
84PAK40.55438361
85KSR20.55180761
86IRAK20.55174056
87MARK30.54980485
88PDGFRA0.54954980
89BTK0.54933311
90RPS6KL10.54580067
91RPS6KC10.54580067
92CLK10.54373593
93MAPKAPK50.52839407
94EPHA30.51529645
95PAK10.51191933
96RPS6KA40.50072635
97INSR0.49657453
98ERBB40.49484694
99MAP2K10.48312449
100CDK60.46810456
101EPHA20.46765266
102PIK3CG0.46134143
103IRAK10.45866640
104JAK20.43958780
105PRKG20.43646561
106ADRBK10.43231258
107IGF1R0.42675774
108PDK20.42475673
109DAPK20.41909887
110RPS6KA20.41782422
111CAMK2D0.40244650
112CSF1R0.39383264
113GRK50.39306512
114LRRK20.38319052
115MAP2K60.38167377
116FYN0.37467317
117MAP3K120.37349077
118PDPK10.37297668
119MET0.34269280
120PTK60.31647653
121TESK20.30962631
122NUAK10.30755779
123RPS6KA60.30624242
124MAPK70.30210851
125PTK20.29850859
126MAP3K10.29343378
127DYRK1B0.29152631
128PRKD10.28426857
129MAP3K110.27519030
130SIK30.25626905
131CAMK1G0.25610225
132TAOK30.24962089
133MYLK0.24029251
134CAMK2G0.22020413
135PDK10.21436359

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.51692569
2Legionellosis_Homo sapiens_hsa051343.28263316
3* Malaria_Homo sapiens_hsa051443.07978159
4Leishmaniasis_Homo sapiens_hsa051403.05696201
5* Rheumatoid arthritis_Homo sapiens_hsa053232.76617620
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.68819361
7Osteoclast differentiation_Homo sapiens_hsa043802.33565910
8Lysosome_Homo sapiens_hsa041422.31269480
9Pertussis_Homo sapiens_hsa051332.20781230
10Tuberculosis_Homo sapiens_hsa051522.11091355
11Graft-versus-host disease_Homo sapiens_hsa053322.08333247
12Salmonella infection_Homo sapiens_hsa051322.05534805
13* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040602.04114378
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.01490668
15NF-kappa B signaling pathway_Homo sapiens_hsa040642.01011358
16* TNF signaling pathway_Homo sapiens_hsa046682.00818902
17Phagosome_Homo sapiens_hsa041452.00648044
18* NOD-like receptor signaling pathway_Homo sapiens_hsa046211.87505168
19Asthma_Homo sapiens_hsa053101.78652869
20Allograft rejection_Homo sapiens_hsa053301.75695760
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.69136945
22Complement and coagulation cascades_Homo sapiens_hsa046101.66317747
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.53686443
24Ribosome_Homo sapiens_hsa030101.52368756
25* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.51616661
26Collecting duct acid secretion_Homo sapiens_hsa049661.48130146
27Toxoplasmosis_Homo sapiens_hsa051451.41780853
28African trypanosomiasis_Homo sapiens_hsa051431.41453371
29RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.39212857
30Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38511846
31Amoebiasis_Homo sapiens_hsa051461.37513901
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.36721394
33* Chemokine signaling pathway_Homo sapiens_hsa040621.33691232
34Apoptosis_Homo sapiens_hsa042101.32397637
35Other glycan degradation_Homo sapiens_hsa005111.21583007
36Measles_Homo sapiens_hsa051621.20765159
37Shigellosis_Homo sapiens_hsa051311.18649041
38Hematopoietic cell lineage_Homo sapiens_hsa046401.15829484
39Prion diseases_Homo sapiens_hsa050201.15192909
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.12541029
41* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.09754715
42Antigen processing and presentation_Homo sapiens_hsa046121.09008409
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.08409898
44* Influenza A_Homo sapiens_hsa051641.07331549
45B cell receptor signaling pathway_Homo sapiens_hsa046621.06770552
46Intestinal immune network for IgA production_Homo sapiens_hsa046721.06465907
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05324744
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.04889017
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.04657378
50Arachidonic acid metabolism_Homo sapiens_hsa005901.04195621
51Viral myocarditis_Homo sapiens_hsa054161.00932510
52Type I diabetes mellitus_Homo sapiens_hsa049400.98905054
53ECM-receptor interaction_Homo sapiens_hsa045120.98323266
54Sulfur metabolism_Homo sapiens_hsa009200.96756529
55Mineral absorption_Homo sapiens_hsa049780.96148121
56Hepatitis B_Homo sapiens_hsa051610.92640867
57Sphingolipid metabolism_Homo sapiens_hsa006000.91793028
58Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90565285
59Proteoglycans in cancer_Homo sapiens_hsa052050.89725295
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89401690
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.85082948
62Small cell lung cancer_Homo sapiens_hsa052220.84371394
63Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82374159
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75518109
65Melanoma_Homo sapiens_hsa052180.74437522
66Focal adhesion_Homo sapiens_hsa045100.73295830
67Chronic myeloid leukemia_Homo sapiens_hsa052200.67388625
68PPAR signaling pathway_Homo sapiens_hsa033200.66841094
69Primary bile acid biosynthesis_Homo sapiens_hsa001200.66442326
70Leukocyte transendothelial migration_Homo sapiens_hsa046700.66028842
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65324411
72Galactose metabolism_Homo sapiens_hsa000520.64582925
73Hepatitis C_Homo sapiens_hsa051600.63903012
74HIF-1 signaling pathway_Homo sapiens_hsa040660.63305207
75* Herpes simplex infection_Homo sapiens_hsa051680.61040446
76Autoimmune thyroid disease_Homo sapiens_hsa053200.59530611
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54392037
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54224799
79Glutathione metabolism_Homo sapiens_hsa004800.53397517
80Acute myeloid leukemia_Homo sapiens_hsa052210.53384660
81Chemical carcinogenesis_Homo sapiens_hsa052040.53193252
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50569201
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.49850613
84Pancreatic cancer_Homo sapiens_hsa052120.48340434
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47218802
86Vibrio cholerae infection_Homo sapiens_hsa051100.46677129
87Platelet activation_Homo sapiens_hsa046110.45926330
88T cell receptor signaling pathway_Homo sapiens_hsa046600.45765642
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45330027
90MicroRNAs in cancer_Homo sapiens_hsa052060.39799072
91PI3K-Akt signaling pathway_Homo sapiens_hsa041510.39463742
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38772553
93Prolactin signaling pathway_Homo sapiens_hsa049170.37440742
94Epstein-Barr virus infection_Homo sapiens_hsa051690.37281058
95Systemic lupus erythematosus_Homo sapiens_hsa053220.36173138
96Renal cell carcinoma_Homo sapiens_hsa052110.35694704
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35628308
98Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35548577
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.35261441
100Synaptic vesicle cycle_Homo sapiens_hsa047210.34048828
101Bladder cancer_Homo sapiens_hsa052190.33312304
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.33287722
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33034271
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32761342
105Caffeine metabolism_Homo sapiens_hsa002320.31692451
106HTLV-I infection_Homo sapiens_hsa051660.31060429
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29444265
108Prostate cancer_Homo sapiens_hsa052150.29407812
109VEGF signaling pathway_Homo sapiens_hsa043700.29195402
110Endocytosis_Homo sapiens_hsa041440.28646031
111p53 signaling pathway_Homo sapiens_hsa041150.28406149
112Rap1 signaling pathway_Homo sapiens_hsa040150.28153540
113Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27791811
114Dilated cardiomyopathy_Homo sapiens_hsa054140.27713900
115Renin-angiotensin system_Homo sapiens_hsa046140.25805201
116Tryptophan metabolism_Homo sapiens_hsa003800.25709267
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.20663742
118Type II diabetes mellitus_Homo sapiens_hsa049300.20321619
119Fructose and mannose metabolism_Homo sapiens_hsa000510.19548267
120GnRH signaling pathway_Homo sapiens_hsa049120.17526042
121Notch signaling pathway_Homo sapiens_hsa043300.13474147
122Primary immunodeficiency_Homo sapiens_hsa053400.12044812
123MAPK signaling pathway_Homo sapiens_hsa040100.10319838

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