CCL15-CCL14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epoxygenase P450 pathway (GO:0019373)7.13261911
2ethanol oxidation (GO:0006069)5.79642993
3exogenous drug catabolic process (GO:0042738)5.70316152
4drug catabolic process (GO:0042737)5.64495292
5angiotensin maturation (GO:0002003)5.59157539
6urea metabolic process (GO:0019627)5.16944121
7complement activation, alternative pathway (GO:0006957)5.15367514
8drug metabolic process (GO:0017144)5.12954889
9regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.05821123
10fat-soluble vitamin biosynthetic process (GO:0042362)4.98137933
11ethanol metabolic process (GO:0006067)4.88517334
12urea cycle (GO:0000050)4.86014580
13complement activation, classical pathway (GO:0006958)4.83682694
14cellular glucuronidation (GO:0052695)4.79923488
15nitrogen cycle metabolic process (GO:0071941)4.76089842
16regulation of protein activation cascade (GO:2000257)4.75816106
17uronic acid metabolic process (GO:0006063)4.68130123
18glucuronate metabolic process (GO:0019585)4.68130123
19omega-hydroxylase P450 pathway (GO:0097267)4.67112331
20regulation of complement activation (GO:0030449)4.63728558
21intestinal absorption (GO:0050892)4.56537948
22regulation of triglyceride catabolic process (GO:0010896)4.54810127
23complement activation (GO:0006956)4.47219238
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.26829109
25positive regulation of lipoprotein lipase activity (GO:0051006)4.24752346
26positive regulation of triglyceride lipase activity (GO:0061365)4.24752346
27phospholipid efflux (GO:0033700)4.14742264
28NADH metabolic process (GO:0006734)4.14381357
29bile acid and bile salt transport (GO:0015721)4.14332721
30protein activation cascade (GO:0072376)4.09720370
31regulation of fibrinolysis (GO:0051917)4.07540368
32fructose metabolic process (GO:0006000)4.06589233
33hormone catabolic process (GO:0042447)4.01069106
34protein-lipid complex remodeling (GO:0034368)3.95825082
35macromolecular complex remodeling (GO:0034367)3.95825082
36plasma lipoprotein particle remodeling (GO:0034369)3.95825082
37regulation of cholesterol esterification (GO:0010872)3.93336108
38very-low-density lipoprotein particle assembly (GO:0034379)3.92670846
39bile acid metabolic process (GO:0008206)3.90398997
40acute-phase response (GO:0006953)3.87913993
41negative regulation of fibrinolysis (GO:0051918)3.85915028
42negative regulation of cholesterol transport (GO:0032375)3.76728139
43negative regulation of sterol transport (GO:0032372)3.76728139
44glyoxylate metabolic process (GO:0046487)3.75479590
45L-phenylalanine metabolic process (GO:0006558)3.72787240
46erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.72787240
47flavonoid metabolic process (GO:0009812)3.72367583
48erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.71500038
49L-phenylalanine catabolic process (GO:0006559)3.71500038
50regulation of guanylate cyclase activity (GO:0031282)3.71329853
51regulation of bile acid biosynthetic process (GO:0070857)3.70343598
52arginine metabolic process (GO:0006525)3.66102481
53phenylpropanoid metabolic process (GO:0009698)3.59412480
54plasma lipoprotein particle assembly (GO:0034377)3.59364544
55diacylglycerol metabolic process (GO:0046339)3.59303156
56primary alcohol catabolic process (GO:0034310)3.56615501
57alkaloid metabolic process (GO:0009820)3.56286453
58fibrinolysis (GO:0042730)3.53135444
59fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.50504569
60regulation of cellular extravasation (GO:0002691)3.48569280
61high-density lipoprotein particle remodeling (GO:0034375)3.48547289
62lipoprotein transport (GO:0042953)3.48445862
63low-density lipoprotein particle remodeling (GO:0034374)3.47997113
64positive regulation of fatty acid biosynthetic process (GO:0045723)3.45504225
65positive regulation of lipid catabolic process (GO:0050996)3.45503832
66cholesterol efflux (GO:0033344)3.41767501
67lipoprotein metabolic process (GO:0042157)3.40822858
68plasma lipoprotein particle organization (GO:0071827)3.37800879
69renal system process involved in regulation of blood volume (GO:0001977)3.36135419
70negative regulation of blood coagulation (GO:0030195)3.34916561
71negative regulation of hemostasis (GO:1900047)3.34916561
72protein carboxylation (GO:0018214)3.33645043
73peptidyl-glutamic acid carboxylation (GO:0017187)3.33645043
74protein-lipid complex assembly (GO:0065005)3.29386103
75protein-lipid complex subunit organization (GO:0071825)3.22755890
76reverse cholesterol transport (GO:0043691)3.19436983
77regulation of humoral immune response (GO:0002920)3.17524731
78bile acid biosynthetic process (GO:0006699)3.15454665
79virion attachment to host cell (GO:0019062)3.13487563
80adhesion of symbiont to host cell (GO:0044650)3.13487563
81maintenance of gastrointestinal epithelium (GO:0030277)3.12951080
82negative regulation of coagulation (GO:0050819)3.12692511
83regulation of vitamin metabolic process (GO:0030656)3.09757721
84regulation of systemic arterial blood pressure by hormone (GO:0001990)3.08420596
85regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.08420596
86endocrine process (GO:0050886)3.08420596
87renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)3.07755382
88primary alcohol metabolic process (GO:0034308)3.00494409
89aromatic amino acid family catabolic process (GO:0009074)2.98288516
90positive regulation of pseudopodium assembly (GO:0031274)2.96071487
91triglyceride homeostasis (GO:0070328)2.94714423
92acylglycerol homeostasis (GO:0055090)2.94714423
93negative regulation of wound healing (GO:0061045)2.94360502
94positive regulation of respiratory burst (GO:0060267)2.89897472
95antimicrobial humoral response (GO:0019730)2.89325569
96glutamine family amino acid biosynthetic process (GO:0009084)2.88634380
97xenobiotic metabolic process (GO:0006805)2.87696170
98glycosphingolipid catabolic process (GO:0046479)2.85516988
99acute inflammatory response (GO:0002526)2.85373153
100blood coagulation, intrinsic pathway (GO:0007597)2.85297370

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.26441352
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.17147768
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.63262868
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.52099416
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.46362429
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.43231352
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.38015610
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.32032055
9CDX2_20551321_ChIP-Seq_CACO-2_Human3.16418435
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.95781653
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.70052769
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.60205364
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.18424618
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.16904656
15SOX2_27498859_Chip-Seq_STOMACH_Mouse2.12224041
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.00248005
17GATA4_25053715_ChIP-Seq_YYC3_Human1.93819968
18TP63_17297297_ChIP-ChIP_HaCaT_Human1.93471167
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.92064111
20SOX2_20726797_ChIP-Seq_SW620_Human1.83148365
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.81961930
22CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.79626551
23LXR_22292898_ChIP-Seq_THP-1_Human1.79464669
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.76759721
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63854410
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.63159950
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.63128599
28GATA6_25053715_ChIP-Seq_YYC3_Human1.59587269
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.58674953
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52373782
31FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52249567
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.47823236
33BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.47073151
34PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.40192939
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37221699
36HNF4A_19822575_ChIP-Seq_HepG2_Human1.36559551
37BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.36066796
38FOXA2_19822575_ChIP-Seq_HepG2_Human1.34594647
39NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.33400842
40CLOCK_20551151_ChIP-Seq_293T_Human1.27453588
41IRF8_27001747_Chip-Seq_BMDM_Mouse1.26123169
42RACK7_27058665_Chip-Seq_MCF-7_Human1.23548975
43SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22136801
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.22115457
45SRY_22984422_ChIP-ChIP_TESTIS_Rat1.19802639
46GATA1_22025678_ChIP-Seq_K562_Human1.16278856
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.15674204
48SA1_27219007_Chip-Seq_Bcells_Human1.14706326
49NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14076064
50SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13365886
51AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.13298093
52CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11486269
53BCOR_27268052_Chip-Seq_Bcells_Human1.10645544
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10205527
55KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10170306
56BCL6_27268052_Chip-Seq_Bcells_Human1.08787702
57SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06538214
58TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.05288730
59P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04049413
60RAD21_21589869_ChIP-Seq_MESCs_Mouse1.02095899
61ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.00388104
62ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00317087
63TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99389574
64CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98939192
65CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98665303
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98600599
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95822738
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93804419
69STAT1_20625510_ChIP-Seq_HELA_Human0.92295518
70CTCF_27219007_Chip-Seq_Bcells_Human0.92069834
71FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91611123
72PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90942659
73GATA1_19941826_ChIP-Seq_K562_Human0.90073830
74TET1_21451524_ChIP-Seq_MESCs_Mouse0.89771701
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89631429
76SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.88482789
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87669434
78ELK3_25401928_ChIP-Seq_HUVEC_Human0.86350538
79DNAJC2_21179169_ChIP-ChIP_NT2_Human0.85210705
80FOXA1_25552417_ChIP-Seq_VCAP_Human0.83956276
81VDR_24763502_ChIP-Seq_THP-1_Human0.83815316
82KLF5_25053715_ChIP-Seq_YYC3_Human0.83289620
83PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.83110902
84CTCF_20526341_ChIP-Seq_ESCs_Human0.82847153
85CEBPB_22108803_ChIP-Seq_LS180_Human0.81631243
86JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.81535805
87SMC4_20622854_ChIP-Seq_HELA_Human0.81181904
88STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.79539812
89PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79462597
90GATA2_19941826_ChIP-Seq_K562_Human0.78986986
91RUNX1_27514584_Chip-Seq_MCF-7_Human0.78016087
92GATA1_22383799_ChIP-Seq_G1ME_Mouse0.74379838
93E2F1_20622854_ChIP-Seq_HELA_Human0.74186178
94DROSHA_22980978_ChIP-Seq_HELA_Human0.74070327
95E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.73053040
96EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.72994307
97PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.72481285
98TP63_22573176_ChIP-Seq_HFKS_Human0.72349236
99P300_27268052_Chip-Seq_Bcells_Human0.72203529
100ZNF263_19887448_ChIP-Seq_K562_Human0.71928916

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.33648367
2MP0005360_urolithiasis6.75891088
3MP0005085_abnormal_gallbladder_physiolo4.65288869
4MP0005365_abnormal_bile_salt4.34586576
5MP0001666_abnormal_nutrient_absorption3.91060066
6MP0008875_abnormal_xenobiotic_pharmacok3.34342418
7MP0009840_abnormal_foam_cell3.26052364
8MP0002138_abnormal_hepatobiliary_system2.56654101
9MP0004019_abnormal_vitamin_homeostasis2.55090570
10MP0010155_abnormal_intestine_physiology2.48321439
11MP0010329_abnormal_lipoprotein_level2.34119279
12MP0003252_abnormal_bile_duct2.23671624
13MP0003195_calcinosis2.23354519
14MP0003868_abnormal_feces_composition2.17556808
15MP0003806_abnormal_nucleotide_metabolis2.05233995
16MP0010234_abnormal_vibrissa_follicle2.04745135
17MP0003183_abnormal_peptide_metabolism2.00499920
18MP0003191_abnormal_cellular_cholesterol1.98716780
19MP0003303_peritoneal_inflammation1.96142455
20MP0005332_abnormal_amino_acid1.89582379
21MP0009379_abnormal_foot_pigmentation1.71767561
22MP0002876_abnormal_thyroid_physiology1.69736262
23MP0009785_altered_susceptibility_to1.68476585
24MP0005166_decreased_susceptibility_to1.67114187
25MP0005451_abnormal_body_composition1.61724514
26MP0009643_abnormal_urine_homeostasis1.58380240
27MP0001764_abnormal_homeostasis1.49586149
28MP0005058_abnormal_lysosome_morphology1.48413530
29MP0004264_abnormal_extraembryonic_tissu1.47737544
30MP0002118_abnormal_lipid_homeostasis1.46002833
31MP0000609_abnormal_liver_physiology1.45599555
32MP0003436_decreased_susceptibility_to1.39413572
33MP0003866_abnormal_defecation1.35644382
34MP0003724_increased_susceptibility_to1.34589079
35MP0009764_decreased_sensitivity_to1.32056727
36MP0006082_CNS_inflammation1.30866640
37MP0000604_amyloidosis1.25412096
38MP0005025_abnormal_response_to1.22698712
39MP0003075_altered_response_to1.20020706
40MP0008469_abnormal_protein_level1.19332113
41MP0005636_abnormal_mineral_homeostasis1.18144346
42MP0001845_abnormal_inflammatory_respons1.17727879
43MP0005387_immune_system_phenotype1.16184504
44MP0001790_abnormal_immune_system1.16184504
45MP0002148_abnormal_hypersensitivity_rea1.14622016
46MP0001663_abnormal_digestive_system1.14416839
47MP0004043_abnormal_pH_regulation1.13828788
48MP0005319_abnormal_enzyme/_coenzyme1.11287168
49MP0003879_abnormal_hair_cell1.08656092
50MP0001664_abnormal_digestion1.08636672
51MP0004782_abnormal_surfactant_physiolog1.07193112
52MP0010352_gastrointestinal_tract_polyps1.06658619
53MP0001835_abnormal_antigen_presentation1.06502583
54MP0005584_abnormal_enzyme/coenzyme_acti1.05098713
55MP0002136_abnormal_kidney_physiology1.01402257
56MP0000678_abnormal_parathyroid_gland0.99459966
57MP0005409_darkened_coat_color0.98819608
58MP0000490_abnormal_crypts_of0.98307974
59MP0001873_stomach_inflammation0.97144740
60MP0004147_increased_porphyrin_level0.96325392
61MP0000477_abnormal_intestine_morphology0.95232774
62MP0004858_abnormal_nervous_system0.94801262
63MP0001765_abnormal_ion_homeostasis0.94143825
64MP0001533_abnormal_skeleton_physiology0.90041709
65MP0005381_digestive/alimentary_phenotyp0.88420516
66MP0002971_abnormal_brown_adipose0.87852603
67MP0005535_abnormal_body_temperature0.85180957
68MP0002419_abnormal_innate_immunity0.82978051
69MP0009763_increased_sensitivity_to0.82515980
70MP0003300_gastrointestinal_ulcer0.82442036
71MP0009642_abnormal_blood_homeostasis0.80912291
72MP0005670_abnormal_white_adipose0.80130023
73MP0000249_abnormal_blood_vessel0.79683825
74MP0001756_abnormal_urination0.78766003
75MP0002132_abnormal_respiratory_system0.77470815
76MP0005000_abnormal_immune_tolerance0.77062005
77MP0005671_abnormal_response_to0.74771851
78MP0005448_abnormal_energy_balance0.74354676
79MP0004947_skin_inflammation0.72875445
80MP0005165_increased_susceptibility_to0.72726544
81MP0009333_abnormal_splenocyte_physiolog0.72588165
82MP0000685_abnormal_immune_system0.72375297
83MP0001800_abnormal_humoral_immune0.71661193
84MP0003329_amyloid_beta_deposits0.70614106
85MP0004510_myositis0.70154890
86MP0008004_abnormal_stomach_pH0.65156149
87MP0005464_abnormal_platelet_physiology0.64604187
88MP0002796_impaired_skin_barrier0.63846449
89MP0009765_abnormal_xenobiotic_induced0.62744734
90MP0000465_gastrointestinal_hemorrhage0.61896844
91MP0002998_abnormal_bone_remodeling0.61243834
92MP0005376_homeostasis/metabolism_phenot0.60809676
93MP0005023_abnormal_wound_healing0.60583149
94MP0009115_abnormal_fat_cell0.59046934
95MP0003453_abnormal_keratinocyte_physiol0.58881822
96MP0002723_abnormal_immune_serum0.58555294
97MP0001501_abnormal_sleep_pattern0.57419487
98MP0005164_abnormal_response_to0.56971619
99MP0000598_abnormal_liver_morphology0.55940952
100MP0000858_altered_metastatic_potential0.55638144

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)7.42647569
2Complement deficiency (HP:0004431)7.02075186
3Abnormality of monocarboxylic acid metabolism (HP:0010996)6.94971102
4Abnormality of glutamine family amino acid metabolism (HP:0010902)6.63687491
5Abnormality of complement system (HP:0005339)5.97225504
6Hypobetalipoproteinemia (HP:0003563)5.43351064
7Glomerulonephritis (HP:0000099)5.10744090
8Malnutrition (HP:0004395)4.87724089
9Deep venous thrombosis (HP:0002625)4.74364621
10Abnormality of aromatic amino acid family metabolism (HP:0004338)4.41152837
11Xanthomatosis (HP:0000991)4.26877978
12Hydroxyprolinuria (HP:0003080)4.04055276
13Abnormality of proline metabolism (HP:0010907)4.04055276
14Prolonged partial thromboplastin time (HP:0003645)3.95399974
15Fat malabsorption (HP:0002630)3.74791830
16Conjugated hyperbilirubinemia (HP:0002908)3.73454001
17Nephritis (HP:0000123)3.72478512
18Intrahepatic cholestasis (HP:0001406)3.38862863
19Recurrent gram-negative bacterial infections (HP:0005420)3.36310724
20Hemorrhage of the eye (HP:0011885)3.30892707
21Abnormality of pyrimidine metabolism (HP:0004353)3.11385722
22Hypolipoproteinemia (HP:0010981)3.11110274
23Joint hemorrhage (HP:0005261)3.03408778
24Hyperlipoproteinemia (HP:0010980)3.01703750
25Hyperactive renin-angiotensin system (HP:0000841)2.91568321
26Widely patent fontanelles and sutures (HP:0004492)2.88380599
27Alkalosis (HP:0001948)2.87519757
28Hyperammonemia (HP:0001987)2.84879919
29Steatorrhea (HP:0002570)2.77704793
30Abnormality of vitamin metabolism (HP:0100508)2.76968628
31Chronic diarrhea (HP:0002028)2.75309147
32Abnormality of the nasal mucosa (HP:0000433)2.65793687
33Decreased circulating renin level (HP:0003351)2.63289049
34Purpura (HP:0000979)2.61205228
35Nausea (HP:0002018)2.60458309
36Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.55471542
37Ileus (HP:0002595)2.49877319
38Nasal polyposis (HP:0100582)2.45563622
39Abnormality of serine family amino acid metabolism (HP:0010894)2.44597274
40Abnormality of glycine metabolism (HP:0010895)2.44597274
41Eczematoid dermatitis (HP:0000976)2.42086115
42Glycosuria (HP:0003076)2.38849625
43Abnormality of urine glucose concentration (HP:0011016)2.38849625
44Abnormality of the vitamin B12 metabolism (HP:0004341)2.38287745
45Abnormality of nucleobase metabolism (HP:0010932)2.35775361
46Hypophosphatemia (HP:0002148)2.34971337
47Hyperglycinuria (HP:0003108)2.32953674
48Abnormality of vitamin B metabolism (HP:0004340)2.28658194
49Abdominal distention (HP:0003270)2.25911936
50Generalized aminoaciduria (HP:0002909)2.17315443
51Pancreatitis (HP:0001733)2.16914976
52Proximal tubulopathy (HP:0000114)2.12136188
53Confusion (HP:0001289)2.10774640
54Rickets (HP:0002748)2.10141668
55Abnormality of the common coagulation pathway (HP:0010990)2.09971298
56Amyloidosis (HP:0011034)2.09255163
57Spontaneous abortion (HP:0005268)2.08228760
58Acanthocytosis (HP:0001927)2.06763524
59Epidermoid cyst (HP:0200040)2.06544246
60Metabolic acidosis (HP:0001942)2.05293203
61Abnormality of renin-angiotensin system (HP:0000847)2.05236953
62Cerebral palsy (HP:0100021)2.05202165
63Thin bony cortex (HP:0002753)2.04624104
64Nephrolithiasis (HP:0000787)2.04567715
65Metabolic alkalosis (HP:0200114)2.03398156
66Vascular calcification (HP:0004934)2.02124683
67Pigmentary retinal degeneration (HP:0001146)2.02007357
68Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.01965823
69Wide cranial sutures (HP:0010537)2.01322864
70Abnormality of purine metabolism (HP:0004352)2.01120613
71Hypotension (HP:0002615)1.99883866
72Potter facies (HP:0002009)1.96124491
73Facial shape deformation (HP:0011334)1.96124491
74Abnormality of aspartate family amino acid metabolism (HP:0010899)1.93998997
75Irritability (HP:0000737)1.93273673
76Protuberant abdomen (HP:0001538)1.92483111
77Hyperuricemia (HP:0002149)1.91782945
78Increased purine levels (HP:0004368)1.91782945
79Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89666656
80Dicarboxylic aciduria (HP:0003215)1.89666656
81Hyperphosphaturia (HP:0003109)1.89370965
82Flat acetabular roof (HP:0003180)1.87559327
83Abnormal enzyme/coenzyme activity (HP:0012379)1.87224010
84Pulmonary embolism (HP:0002204)1.85915208
85Abnormality of alkaline phosphatase activity (HP:0004379)1.85590612
86Gingival bleeding (HP:0000225)1.84988982
87Mucopolysacchariduria (HP:0008155)1.83646488
88Urinary glycosaminoglycan excretion (HP:0003541)1.83646488
89Abnormality of iron homeostasis (HP:0011031)1.83589384
90Delayed CNS myelination (HP:0002188)1.82814502
91Gout (HP:0001997)1.81400160
92Thrombophlebitis (HP:0004418)1.81099054
93Joint swelling (HP:0001386)1.80448420
94Congenital sensorineural hearing impairment (HP:0008527)1.80423906
95Focal segmental glomerulosclerosis (HP:0000097)1.79649362
96Elevated alkaline phosphatase (HP:0003155)1.78057844
97Orchitis (HP:0100796)1.77843137
98Increased serum ferritin (HP:0003281)1.77512239
99Abnormal urine phosphate concentration (HP:0012599)1.75286306
100Abnormal respiratory epithelium morphology (HP:0012253)1.74764843

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.16586517
2ACVR1B4.83553449
3RIPK13.90957620
4MST1R3.88831643
5EPHA23.10491740
6FGFR42.64474334
7TYK22.38432003
8PRKG22.17023162
9TBK11.93626408
10DDR21.93479381
11IRAK31.89921257
12MAP3K31.87370237
13EPHA31.66603341
14MATK1.59583705
15MAPK151.59133532
16PIK3CA1.58517574
17MAP3K21.54149892
18EPHB21.48304480
19MAP4K11.46640360
20MAP3K111.45079062
21CDC42BPA1.44670868
22TAOK11.39407157
23RIPK41.38584601
24EPHB11.38210737
25STK241.37849058
26PRPF4B1.33030256
27PTK61.32650041
28MAP3K11.32003268
29CSK1.25515691
30TESK11.23873310
31MAP3K121.23317480
32FGFR31.23215044
33MAP3K141.21299716
34IKBKE1.20900993
35TESK21.20468943
36MET1.19575760
37TRIB31.11000605
38MYLK1.07234143
39MST41.05054233
40PDPK11.03775103
41LMTK21.02325973
42ZAP700.99360522
43TAOK20.97872386
44ABL20.95836546
45TGFBR20.92049619
46PRKAA20.88952080
47TXK0.88521161
48GRK60.86726764
49MAP2K20.85928153
50SIK10.84116553
51JAK10.84030510
52MAP2K60.81635418
53DYRK1B0.78253500
54BLK0.77720693
55STK390.77662625
56PDK20.77544504
57MAPK110.77243722
58MAP3K100.76836189
59PRKACG0.76482174
60PIM20.75625731
61GRK70.72435572
62FER0.71814489
63JAK30.71190871
64NME20.71115069
65MAPKAPK30.71033662
66IRAK40.70878739
67IRAK10.70548335
68JAK20.70394446
69NLK0.67627140
70ERBB20.66587110
71PDK10.66303820
72OXSR10.61150155
73IKBKB0.60605175
74SMG10.58125213
75CSF1R0.56819340
76BMPR20.56774194
77PDGFRA0.53556260
78FGR0.51245043
79PAK40.50412653
80LYN0.50040471
81SRC0.47658219
82PRKCA0.46907737
83KIT0.45129864
84PRKCZ0.44332446
85CDK60.44139225
86MAPK70.43542080
87KDR0.40072020
88CHUK0.37715089
89IGF1R0.37484356
90SYK0.36868388
91CAMK2G0.36728819
92BMX0.36713764
93FYN0.34866824
94PRKCD0.34088135
95ADRBK20.33733829
96LCK0.33021346
97RET0.31028260
98CAMK2D0.29420267
99LRRK20.28416668
100PRKCQ0.27622740

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002323.65003515
2Cyanoamino acid metabolism_Homo sapiens_hsa004603.37065024
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.90133360
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.78681435
5Retinol metabolism_Homo sapiens_hsa008302.76168926
6Arginine biosynthesis_Homo sapiens_hsa002202.74404968
7Fat digestion and absorption_Homo sapiens_hsa049752.74331304
8Chemical carcinogenesis_Homo sapiens_hsa052042.74325837
9Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.70111074
10Complement and coagulation cascades_Homo sapiens_hsa046102.69594732
11Histidine metabolism_Homo sapiens_hsa003402.54633531
12Pentose and glucuronate interconversions_Homo sapiens_hsa000402.42594086
13Drug metabolism - other enzymes_Homo sapiens_hsa009832.21047516
14Primary bile acid biosynthesis_Homo sapiens_hsa001202.20969663
15Fatty acid degradation_Homo sapiens_hsa000712.14691267
16Phenylalanine metabolism_Homo sapiens_hsa003602.13065651
17Vitamin digestion and absorption_Homo sapiens_hsa049772.06397424
18Steroid hormone biosynthesis_Homo sapiens_hsa001402.05870048
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.01980497
20Staphylococcus aureus infection_Homo sapiens_hsa051501.98706204
21Sulfur metabolism_Homo sapiens_hsa009201.91824269
22Renin-angiotensin system_Homo sapiens_hsa046141.87041311
23Linoleic acid metabolism_Homo sapiens_hsa005911.84655200
24Starch and sucrose metabolism_Homo sapiens_hsa005001.78595514
25Tyrosine metabolism_Homo sapiens_hsa003501.72806807
26PPAR signaling pathway_Homo sapiens_hsa033201.70252517
27Tryptophan metabolism_Homo sapiens_hsa003801.63255556
28Bile secretion_Homo sapiens_hsa049761.60683665
29Fructose and mannose metabolism_Homo sapiens_hsa000511.49944603
30Mineral absorption_Homo sapiens_hsa049781.49740298
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45414432
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.43902600
33Arachidonic acid metabolism_Homo sapiens_hsa005901.40165419
34Asthma_Homo sapiens_hsa053101.23500150
35Arginine and proline metabolism_Homo sapiens_hsa003301.23323253
36Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13670295
37Prion diseases_Homo sapiens_hsa050201.08640401
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05293600
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98821734
40Peroxisome_Homo sapiens_hsa041460.98640317
41alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96558597
42Other glycan degradation_Homo sapiens_hsa005110.96039740
43Allograft rejection_Homo sapiens_hsa053300.95349709
44Intestinal immune network for IgA production_Homo sapiens_hsa046720.94216224
45Pertussis_Homo sapiens_hsa051330.90333441
46Butanoate metabolism_Homo sapiens_hsa006500.90263032
47Galactose metabolism_Homo sapiens_hsa000520.88218668
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.87583360
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.87496822
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.86860599
51Protein digestion and absorption_Homo sapiens_hsa049740.85838884
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84442361
53Glycerolipid metabolism_Homo sapiens_hsa005610.82902399
54Glutathione metabolism_Homo sapiens_hsa004800.81327878
55Autoimmune thyroid disease_Homo sapiens_hsa053200.80908543
56Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77610328
57Graft-versus-host disease_Homo sapiens_hsa053320.77242465
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72570320
59Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71592880
60beta-Alanine metabolism_Homo sapiens_hsa004100.67408089
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63462972
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62430628
63Type I diabetes mellitus_Homo sapiens_hsa049400.61363937
64Sulfur relay system_Homo sapiens_hsa041220.55101786
65Fatty acid metabolism_Homo sapiens_hsa012120.54621755
66Biosynthesis of amino acids_Homo sapiens_hsa012300.53221943
67Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47926831
68Carbon metabolism_Homo sapiens_hsa012000.46222634
69Leishmaniasis_Homo sapiens_hsa051400.45982863
70ABC transporters_Homo sapiens_hsa020100.45336079
71Sphingolipid metabolism_Homo sapiens_hsa006000.41310190
72Pyruvate metabolism_Homo sapiens_hsa006200.39050361
73Ether lipid metabolism_Homo sapiens_hsa005650.38402657
74Antigen processing and presentation_Homo sapiens_hsa046120.37826878
75African trypanosomiasis_Homo sapiens_hsa051430.36094338
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34775919
77Glycosaminoglycan degradation_Homo sapiens_hsa005310.31753809
78Insulin resistance_Homo sapiens_hsa049310.31102248
79Rheumatoid arthritis_Homo sapiens_hsa053230.29842663
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.29469910
81Folate biosynthesis_Homo sapiens_hsa007900.29466680
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.28565421
83Pentose phosphate pathway_Homo sapiens_hsa000300.27779236
84Metabolic pathways_Homo sapiens_hsa011000.27653623
85Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.26382323
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.26072934
87Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.26057806
88Hepatitis C_Homo sapiens_hsa051600.23662257
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23270513
90Pancreatic secretion_Homo sapiens_hsa049720.22950975
91Amoebiasis_Homo sapiens_hsa051460.22658564
92Lysosome_Homo sapiens_hsa041420.20711155
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.20273871
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18445664
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.16514572
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.15961692
97Hematopoietic cell lineage_Homo sapiens_hsa046400.15224350
98Tuberculosis_Homo sapiens_hsa051520.14562138
99TNF signaling pathway_Homo sapiens_hsa046680.14231898
100Fatty acid biosynthesis_Homo sapiens_hsa000610.13643343

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