CCL14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene, chemokine (C-C motif) ligand 14, is one of several CC cytokine genes clustered on 17q11.2. The CC cytokines are secreted proteins characterized by two adjacent cysteines. The cytokine encoded by this gene induces changes in intracellular calcium concentration and enzyme release in monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Read-through transcripts are also expressed that include exons from the upstream cytokine gene, chemokine (C-C motif) ligand 15, and are represented as GeneID: 348249. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)6.06562116
2ethanol oxidation (GO:0006069)5.49364573
3triglyceride catabolic process (GO:0019433)5.47017413
4transcytosis (GO:0045056)4.90075010
5neutral lipid catabolic process (GO:0046461)4.89256249
6acylglycerol catabolic process (GO:0046464)4.89256249
7endothelium development (GO:0003158)4.66255272
8complement activation, alternative pathway (GO:0006957)4.57232158
9complement activation (GO:0006956)4.53225698
10regulation of sequestering of triglyceride (GO:0010889)4.50033812
11complement activation, classical pathway (GO:0006958)4.49097336
12positive regulation of lipoprotein lipase activity (GO:0051006)4.48891918
13positive regulation of triglyceride lipase activity (GO:0061365)4.48891918
14triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.42754674
15ethanol metabolic process (GO:0006067)4.35471767
16glomerular filtration (GO:0003094)4.14153039
17protein activation cascade (GO:0072376)3.98732967
18ovulation from ovarian follicle (GO:0001542)3.92947708
19negative regulation of granulocyte differentiation (GO:0030853)3.79111567
20renal filtration (GO:0097205)3.63800613
21plasma lipoprotein particle clearance (GO:0034381)3.53748645
22regulation of plasminogen activation (GO:0010755)3.48586290
23polyol transport (GO:0015791)3.48204161
24response to dietary excess (GO:0002021)3.45652786
25regulation of complement activation (GO:0030449)3.44390883
26acylglycerol homeostasis (GO:0055090)3.44232199
27triglyceride homeostasis (GO:0070328)3.44232199
28glycerolipid catabolic process (GO:0046503)3.40277177
29regulation of protein activation cascade (GO:2000257)3.39820778
30negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.39341974
31primary alcohol metabolic process (GO:0034308)3.29158087
32diacylglycerol metabolic process (GO:0046339)3.28772295
33regulation of lipoprotein metabolic process (GO:0050746)3.22203238
34regulation of cholesterol storage (GO:0010885)3.17575641
35sexual reproduction (GO:0019953)3.12536943
36NADH metabolic process (GO:0006734)3.12252423
37retina vasculature morphogenesis in camera-type eye (GO:0061299)3.11825869
38regulation of triglyceride catabolic process (GO:0010896)3.09646169
39cGMP-mediated signaling (GO:0019934)3.08977383
40lipid storage (GO:0019915)3.08125433
41fusion of sperm to egg plasma membrane (GO:0007342)3.03273541
42cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.03253715
43blood coagulation, intrinsic pathway (GO:0007597)3.02849132
44fatty acid homeostasis (GO:0055089)3.01399323
45positive regulation of cholesterol efflux (GO:0010875)2.99524515
46regulation of macrophage derived foam cell differentiation (GO:0010743)2.98787620
47positive regulation of glomerulus development (GO:0090193)2.97065099
48response to phenylpropanoid (GO:0080184)2.95393884
49hyaluronan catabolic process (GO:0030214)2.91956672
50phospholipid homeostasis (GO:0055091)2.89781663
51negative regulation of complement activation (GO:0045916)2.87484142
52negative regulation of protein activation cascade (GO:2000258)2.85814441
53surfactant homeostasis (GO:0043129)2.80704944
54positive regulation of receptor recycling (GO:0001921)2.80373693
55low-density lipoprotein particle remodeling (GO:0034374)2.77356683
56triglyceride metabolic process (GO:0006641)2.75812048
57positive regulation of lipid storage (GO:0010884)2.75509036
58keratan sulfate catabolic process (GO:0042340)2.75375906
59extracellular fibril organization (GO:0043206)2.74921191
60cellular response to epinephrine stimulus (GO:0071872)2.74167775
61protein-lipid complex remodeling (GO:0034368)2.73298974
62macromolecular complex remodeling (GO:0034367)2.73298974
63plasma lipoprotein particle remodeling (GO:0034369)2.73298974
64barbed-end actin filament capping (GO:0051016)2.72441642
65regulation of sterol transport (GO:0032371)2.71616021
66regulation of cholesterol transport (GO:0032374)2.71616021
67angiogenesis involved in wound healing (GO:0060055)2.69718981
68negative regulation of smooth muscle cell proliferation (GO:0048662)2.68560387
69regulation of macrophage chemotaxis (GO:0010758)2.66099717
70plasma membrane fusion (GO:0045026)2.66047909
71positive regulation of cellular response to insulin stimulus (GO:1900078)2.65766184
72positive regulation of cholesterol transport (GO:0032376)2.64993271
73positive regulation of sterol transport (GO:0032373)2.64993271
74epoxygenase P450 pathway (GO:0019373)2.64298710
75positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.63640513
76retinol metabolic process (GO:0042572)2.63132201
77negative regulation of protein autophosphorylation (GO:0031953)2.60412645
78opsonization (GO:0008228)2.59984827
79brown fat cell differentiation (GO:0050873)2.59552413
80positive regulation of glycolytic process (GO:0045821)2.59141983
81acrosome reaction (GO:0007340)2.58423681
82endocrine hormone secretion (GO:0060986)2.57743542
83acylglycerol metabolic process (GO:0006639)2.57598074
84protein heterotrimerization (GO:0070208)2.57106867
85neutral lipid metabolic process (GO:0006638)2.53753135
86primary alcohol catabolic process (GO:0034310)2.53172184
87peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.52891788
88L-phenylalanine catabolic process (GO:0006559)2.52424694
89erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.52424694
90fibril organization (GO:0097435)2.52368993
91endothelial cell chemotaxis (GO:0035767)2.49898382
92negative regulation of hemostasis (GO:1900047)2.49300784
93negative regulation of blood coagulation (GO:0030195)2.49300784
94negative regulation of fibrinolysis (GO:0051918)2.46670672
95regulation of endothelial cell differentiation (GO:0045601)2.46329710
96acute-phase response (GO:0006953)2.45211090
97regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.44971834
98regulation of glucose import in response to insulin stimulus (GO:2001273)2.44847806
99peptidyl-glutamic acid carboxylation (GO:0017187)2.44694387
100protein carboxylation (GO:0018214)2.44694387

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.33217196
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.34312699
3RARG_19884340_ChIP-ChIP_MEFs_Mouse2.98843846
4FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.95708859
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.75101867
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.57791456
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.52184780
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.51395026
9MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.47977093
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.35375452
11LXR_22158963_ChIP-Seq_LIVER_Mouse2.33009204
12PPARA_22158963_ChIP-Seq_LIVER_Mouse2.27928411
13CLOCK_20551151_ChIP-Seq_293T_Human1.90138416
14TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.88673157
15GATA2_21666600_ChIP-Seq_HMVEC_Human1.83859864
16LXR_22292898_ChIP-Seq_THP-1_Human1.83239921
17TP63_17297297_ChIP-ChIP_HaCaT_Human1.54478902
18ESR2_21235772_ChIP-Seq_MCF-7_Human1.47737012
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.45536958
20ELK3_25401928_ChIP-Seq_HUVEC_Human1.41556271
21TBX20_22328084_ChIP-Seq_HEART_Mouse1.40921326
22TBX20_22080862_ChIP-Seq_HEART_Mouse1.40921326
23BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.39653388
24CTCF_27219007_Chip-Seq_Bcells_Human1.39552799
25ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37730034
26NFIB_24661679_ChIP-Seq_LUNG_Mouse1.36793232
27NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.34517506
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33810362
29P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33242605
30PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.31694721
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.31160297
32CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.29790224
33SMC4_20622854_ChIP-Seq_HELA_Human1.25280801
34SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25213833
35TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24356137
36RAD21_21589869_ChIP-Seq_MESCs_Mouse1.22853805
37DROSHA_22980978_ChIP-Seq_HELA_Human1.21416340
38PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15026808
39CJUN_26792858_Chip-Seq_BT549_Human1.14902252
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.12943469
41GATA1_19941826_ChIP-Seq_K562_Human1.11791036
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.11711238
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09480322
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.05717104
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.04073243
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02697372
47SA1_27219007_Chip-Seq_Bcells_Human1.02283125
48* TP63_22573176_ChIP-Seq_HFKS_Human1.01473114
49SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01399282
50BCL6_27268052_Chip-Seq_Bcells_Human1.01245474
51* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00951699
52SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00138480
53P68_20966046_ChIP-Seq_HELA_Human0.99701794
54IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.98701880
55RAC3_21632823_ChIP-Seq_H3396_Human0.97411158
56RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97156660
57EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97156660
58ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96993005
59SA1_27219007_Chip-Seq_ERYTHROID_Human0.96546920
60ELF1_20517297_ChIP-Seq_JURKAT_Human0.94191352
61RUNX_20019798_ChIP-Seq_JUKART_Human0.92581470
62SOX9_24532713_ChIP-Seq_HFSC_Mouse0.91532928
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.91529397
64SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.91419064
65BCOR_27268052_Chip-Seq_Bcells_Human0.91262372
66VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.90456713
67PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89895109
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89093206
69PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88865128
70EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.88724406
71GATA1_22025678_ChIP-Seq_K562_Human0.88641866
72* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.88486372
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88380312
74SMC1_22415368_ChIP-Seq_MEFs_Mouse0.87252356
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.86956915
76RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.86682093
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.85843405
78CSB_26484114_Chip-Seq_FIBROBLAST_Human0.84926264
79CTCF_20526341_ChIP-Seq_ESCs_Human0.84547536
80VDR_24787735_ChIP-Seq_THP-1_Human0.83932888
81JARID2_20075857_ChIP-Seq_MESCs_Mouse0.83915277
82YY1_22570637_ChIP-Seq_MALME-3M_Human0.83476349
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.83449153
84SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.82506524
85SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.80289450
86SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79795796
87SA1_22415368_ChIP-Seq_MEFs_Mouse0.79357572
88KLF4_19829295_ChIP-Seq_ESCs_Human0.79071670
89ERA_21632823_ChIP-Seq_H3396_Human0.77893981
90EED_16625203_ChIP-ChIP_MESCs_Mouse0.77729171
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77613907
92FOXA2_19822575_ChIP-Seq_HepG2_Human0.77361977
93EZH2_27294783_Chip-Seq_ESCs_Mouse0.77007650
94SOX11_22085726_ChIP-Seq_ESNs_Mouse0.76883432
95E2F1_20622854_ChIP-Seq_HELA_Human0.76708887
96KDM2B_26808549_Chip-Seq_K562_Human0.76544278
97SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.76080632
98SUZ12_27294783_Chip-Seq_ESCs_Mouse0.76039991
99ERG_21242973_ChIP-ChIP_JURKAT_Human0.74980702
100MYC_27129775_Chip-Seq_CORNEA_Mouse0.74782564

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose6.34301199
2MP0005666_abnormal_adipose_tissue3.85858513
3MP0010368_abnormal_lymphatic_system3.33966713
4MP0003011_delayed_dark_adaptation3.29362760
5MP0005275_abnormal_skin_tensile3.18359818
6MP0005375_adipose_tissue_phenotype2.92262851
7MP0002971_abnormal_brown_adipose2.92097841
8MP0004130_abnormal_muscle_cell2.80555436
9MP0003724_increased_susceptibility_to2.76932352
10MP0005167_abnormal_blood-brain_barrier2.75789838
11MP0001879_abnormal_lymphatic_vessel2.55101766
12MP0010329_abnormal_lipoprotein_level2.41815362
13MP0005503_abnormal_tendon_morphology2.32859072
14MP0009115_abnormal_fat_cell2.30625126
15MP0005410_abnormal_fertilization2.15108028
16MP0004185_abnormal_adipocyte_glucose2.10498052
17MP0003828_pulmonary_edema2.03411102
18MP0003191_abnormal_cellular_cholesterol2.03310029
19MP0002139_abnormal_hepatobiliary_system1.96831437
20MP0006138_congestive_heart_failure1.92482533
21MP0008438_abnormal_cutaneous_collagen1.84590918
22MP0003279_aneurysm1.74634618
23MP0000003_abnormal_adipose_tissue1.73047546
24MP0002876_abnormal_thyroid_physiology1.69188376
25MP0002933_joint_inflammation1.64592801
26MP0005365_abnormal_bile_salt1.63899750
27MP0003868_abnormal_feces_composition1.62388930
28MP0003690_abnormal_glial_cell1.61934138
29MP0005535_abnormal_body_temperature1.60185013
30MP0000751_myopathy1.57816744
31MP0005334_abnormal_fat_pad1.55405804
32MP0002108_abnormal_muscle_morphology1.51309308
33MP0000343_altered_response_to1.49145171
34MP0000249_abnormal_blood_vessel1.49033316
35MP0002138_abnormal_hepatobiliary_system1.48416153
36MP0002796_impaired_skin_barrier1.46570580
37MP0005595_abnormal_vascular_smooth1.45773048
38MP0002970_abnormal_white_adipose1.44668697
39MP0004782_abnormal_surfactant_physiolog1.44668348
40MP0005360_urolithiasis1.42398787
41MP0002118_abnormal_lipid_homeostasis1.42315536
42MP0003705_abnormal_hypodermis_morpholog1.41381777
43MP0003959_abnormal_lean_body1.40587969
44MP0001958_emphysema1.40573143
45MP0003303_peritoneal_inflammation1.23834162
46MP0004272_abnormal_basement_membrane1.20845316
47MP0002295_abnormal_pulmonary_circulatio1.20743740
48MP0005164_abnormal_response_to1.19828117
49MP0003186_abnormal_redox_activity1.19669261
50MP0001544_abnormal_cardiovascular_syste1.16201858
51MP0005385_cardiovascular_system_phenoty1.16201858
52MP0000013_abnormal_adipose_tissue1.14789825
53MP0004036_abnormal_muscle_relaxation1.08025130
54MP0000767_abnormal_smooth_muscle1.04951229
55MP0004084_abnormal_cardiac_muscle1.00538337
56MP0003950_abnormal_plasma_membrane0.99102403
57MP0005448_abnormal_energy_balance0.97952630
58MP0001533_abnormal_skeleton_physiology0.95629906
59MP0005377_hearing/vestibular/ear_phenot0.93336977
60MP0003878_abnormal_ear_physiology0.93336977
61MP0004215_abnormal_myocardial_fiber0.92470221
62MP0000609_abnormal_liver_physiology0.91695079
63MP0005379_endocrine/exocrine_gland_phen0.90163620
64MP0001661_extended_life_span0.89957914
65MP0003075_altered_response_to0.89467208
66MP0005409_darkened_coat_color0.89219479
67MP0009643_abnormal_urine_homeostasis0.87032857
68MP0001851_eye_inflammation0.86160498
69MP0004883_abnormal_blood_vessel0.84912920
70MP0004019_abnormal_vitamin_homeostasis0.84639762
71MP0005085_abnormal_gallbladder_physiolo0.83483818
72MP0005647_abnormal_sex_gland0.80900667
73MP0009780_abnormal_chondrocyte_physiolo0.80387914
74MP0004087_abnormal_muscle_fiber0.77705267
75MP0000759_abnormal_skeletal_muscle0.77641450
76MP0005023_abnormal_wound_healing0.77502706
77MP0005620_abnormal_muscle_contractility0.77445684
78MP0000230_abnormal_systemic_arterial0.77003535
79MP0003566_abnormal_cell_adhesion0.76986126
80MP0005166_decreased_susceptibility_to0.75285541
81MP0003091_abnormal_cell_migration0.74783376
82MP0002638_abnormal_pupillary_reflex0.74767879
83MP0002998_abnormal_bone_remodeling0.73697457
84MP0002127_abnormal_cardiovascular_syste0.72432638
85MP0009840_abnormal_foam_cell0.72123146
86MP0008875_abnormal_xenobiotic_pharmacok0.71038483
87MP0009785_altered_susceptibility_to0.70179186
88MP0002972_abnormal_cardiac_muscle0.70114311
89MP0002078_abnormal_glucose_homeostasis0.70112943
90MP0005058_abnormal_lysosome_morphology0.69835540
91MP0005452_abnormal_adipose_tissue0.69429353
92MP0005388_respiratory_system_phenotype0.69110663
93MP0002133_abnormal_respiratory_system0.69110663
94MP0002132_abnormal_respiratory_system0.67031300
95MP0000749_muscle_degeneration0.66954762
96MP0001764_abnormal_homeostasis0.65876288
97MP0005584_abnormal_enzyme/coenzyme_acti0.65350530
98MP0001614_abnormal_blood_vessel0.64293840
99MP0003948_abnormal_gas_homeostasis0.62600288
100MP0005165_increased_susceptibility_to0.61839550

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)7.46379547
2Systemic lupus erythematosus (HP:0002725)6.99179897
3Abnormality of complement system (HP:0005339)6.83949147
4Hyperlipoproteinemia (HP:0010980)4.84050782
5Glomerulonephritis (HP:0000099)4.70531570
6Acanthosis nigricans (HP:0000956)4.64818053
7Hypertriglyceridemia (HP:0002155)4.33847497
8Oligomenorrhea (HP:0000876)4.22980188
9Nephritis (HP:0000123)4.03814802
10Joint hemorrhage (HP:0005261)3.68726162
11Protrusio acetabuli (HP:0003179)3.64068788
12Asymmetric septal hypertrophy (HP:0001670)3.60597124
13Polycythemia (HP:0001901)3.55977881
14Abnormality of monocarboxylic acid metabolism (HP:0010996)3.49274655
15Aortic aneurysm (HP:0004942)3.37844529
16Muscle fiber splitting (HP:0003555)3.19367379
17Deep venous thrombosis (HP:0002625)3.17034966
18Spontaneous hematomas (HP:0007420)3.16462104
19Increased variability in muscle fiber diameter (HP:0003557)3.06504887
20Hemorrhage of the eye (HP:0011885)2.96031047
21Increased connective tissue (HP:0009025)2.79209338
22Xanthomatosis (HP:0000991)2.77995344
23Hypoalphalipoproteinemia (HP:0003233)2.74955860
24Abnormality of the nasal mucosa (HP:0000433)2.74067201
25Abnormality of skeletal muscle fiber size (HP:0012084)2.71740125
26Amyloidosis (HP:0011034)2.68051884
27Esophageal varix (HP:0002040)2.67989710
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.66226143
29Abnormality of aromatic amino acid family metabolism (HP:0004338)2.61671980
30Lymphangioma (HP:0100764)2.58773367
31Insulin resistance (HP:0000855)2.58769276
32Colitis (HP:0002583)2.57449217
33Difficulty running (HP:0009046)2.48058550
34Recurrent gram-negative bacterial infections (HP:0005420)2.46197363
35Pigmentary retinal degeneration (HP:0001146)2.44764334
36Myocardial infarction (HP:0001658)2.40235181
37Facial shape deformation (HP:0011334)2.39511924
38Potter facies (HP:0002009)2.39511924
39Atrioventricular block (HP:0001678)2.37398123
40Emphysema (HP:0002097)2.35161260
41Hypercholesterolemia (HP:0003124)2.33277881
42Spinal rigidity (HP:0003306)2.29591723
43Prolonged partial thromboplastin time (HP:0003645)2.29016797
44Insulin-resistant diabetes mellitus (HP:0000831)2.28165339
45Vertebral compression fractures (HP:0002953)2.25026303
46Hyporeflexia of lower limbs (HP:0002600)2.21628255
47Cerebral palsy (HP:0100021)2.21173701
48Increased IgE level (HP:0003212)2.20305672
49Type 1 muscle fiber predominance (HP:0003803)2.20232644
50Cerebral aneurysm (HP:0004944)2.19953406
51Subcapsular cataract (HP:0000523)2.16938544
52Growth hormone excess (HP:0000845)2.13472494
53Ectopia lentis (HP:0001083)2.11124003
54Axonal loss (HP:0003447)2.08932123
55Purpura (HP:0000979)2.08499249
56Skin nodule (HP:0200036)2.06615064
57Visceral angiomatosis (HP:0100761)2.03165077
58Polar cataract (HP:0010696)2.01210664
59Portal hypertension (HP:0001409)1.97948650
60Distal lower limb muscle weakness (HP:0009053)1.93560624
61Hematochezia (HP:0002573)1.91442668
62Exercise-induced myalgia (HP:0003738)1.88140689
63Pulmonary hypertension (HP:0002092)1.87944603
64Bone cyst (HP:0012062)1.86958956
65Stroke (HP:0001297)1.86159213
66Gastrointestinal stroma tumor (HP:0100723)1.85257593
67Vascular tortuosity (HP:0004948)1.83869654
68Abnormality of the intrinsic pathway (HP:0010989)1.83677841
69Prolonged bleeding time (HP:0003010)1.82567449
70Hemangiomatosis (HP:0007461)1.80198009
71Ileus (HP:0002595)1.79933619
72Abnormal atrioventricular conduction (HP:0005150)1.77754051
73Hypolipoproteinemia (HP:0010981)1.77101927
74Accelerated skeletal maturation (HP:0005616)1.75144251
75Back pain (HP:0003418)1.74860643
76Venous abnormality (HP:0002624)1.74693025
77Abnormality of the hepatic vasculature (HP:0006707)1.74437217
78Bulbar palsy (HP:0001283)1.74180679
79Steatorrhea (HP:0002570)1.74151480
80Aneurysm (HP:0002617)1.73532409
81Polygenic inheritance (HP:0010982)1.72607030
82Hypercortisolism (HP:0001578)1.71662331
83Heart block (HP:0012722)1.70608423
84Hyperkalemia (HP:0002153)1.70309236
85Epidermoid cyst (HP:0200040)1.69880265
86Cervical subluxation (HP:0003308)1.69328043
87Striae distensae (HP:0001065)1.69140562
88Aortic dissection (HP:0002647)1.67528427
89Pulmonary artery stenosis (HP:0004415)1.65541503
90Abnormal hemoglobin (HP:0011902)1.62799857
91Abnormality of polysaccharide metabolism (HP:0011012)1.62506191
92Abnormality of glycosaminoglycan metabolism (HP:0004371)1.62506191
93Abnormality of mucopolysaccharide metabolism (HP:0011020)1.62506191
94Venous insufficiency (HP:0005293)1.61667129
95Rhabdomyolysis (HP:0003201)1.61381218
96Interstitial pulmonary disease (HP:0006530)1.61205718
97Fat malabsorption (HP:0002630)1.61089281
98Neck muscle weakness (HP:0000467)1.58955816
99Myotonia (HP:0002486)1.58804778
100Azoospermia (HP:0000027)1.58283985

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.52206288
2TGFBR23.46508782
3TESK13.45555444
4DDR23.31983721
5ERN13.21707097
6RIPK12.89778871
7MYLK2.85194501
8EPHB22.51749451
9TRIB32.35021566
10PRKAA21.89780721
11MAPKAPK31.72913079
12MAP3K61.61333894
13KDR1.47696736
14MAPK121.46906713
15FES1.46752463
16TTN1.40926137
17TRPM71.37404220
18PIK3CG1.31954754
19GRK51.29337324
20PDPK11.29131618
21MAP3K131.28023378
22CSK1.27261875
23LATS21.25437313
24SIK11.23002074
25EEF2K1.21677900
26MAPK71.21188939
27STK381.19143178
28PDGFRA1.16803448
29RIPK41.14756978
30FER1.13426546
31MAP3K31.11520269
32MAP3K111.10589612
33CAMK11.09901471
34TGFBR11.08553989
35PTK2B1.08452806
36ABL21.03358728
37EPHB11.02343642
38MAPK41.00785477
39EPHA30.99599201
40TYK20.98993060
41CDC42BPA0.98978530
42INSRR0.97593324
43PLK40.97445961
44KIT0.97357429
45FGFR40.96847904
46MAP3K10.92949154
47TBK10.90087859
48MAPK150.88524651
49OBSCN0.88182265
50DMPK0.82529429
51MOS0.81815168
52BLK0.80156494
53LATS10.79034429
54NLK0.78992974
55MAP3K70.78812323
56ZAP700.76001603
57STK38L0.75587651
58PDK10.75485529
59ARAF0.70894244
60PRKG20.70596706
61MAP2K30.69589765
62MARK20.65778821
63RPS6KA20.63533330
64PRKG10.63095261
65PRKD10.59836673
66MAP2K10.58313146
67JAK30.56660909
68ILK0.56568286
69DYRK1B0.55131041
70JAK20.54740278
71RET0.54721200
72PRKAA10.52892280
73MAP4K10.52690572
74JAK10.52430446
75PAK20.52382910
76NEK90.52042818
77PDGFRB0.51993519
78PRKACG0.51236162
79HIPK20.50425618
80KSR20.50266127
81ADRBK10.48993237
82STK240.47959590
83IGF1R0.47289154
84GRK10.46564422
85MAP2K20.45083616
86GSK3A0.45031035
87PKN10.43995897
88ROCK10.43662898
89TEC0.43592241
90MAPK30.42452180
91FGFR30.42449090
92DAPK30.42217063
93PTK20.42066539
94PRKD30.42018416
95LRRK20.41226123
96RPS6KL10.40464032
97RPS6KC10.40464032
98SGK2230.38464208
99SGK4940.38464208
100TNK20.36748253

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003603.35121706
2PPAR signaling pathway_Homo sapiens_hsa033203.24389105
3Complement and coagulation cascades_Homo sapiens_hsa046103.22737552
4Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.99809965
5Fatty acid degradation_Homo sapiens_hsa000712.88146126
6Histidine metabolism_Homo sapiens_hsa003402.74970906
7Staphylococcus aureus infection_Homo sapiens_hsa051502.64974610
8Tyrosine metabolism_Homo sapiens_hsa003502.54668248
9Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.26776109
10Retinol metabolism_Homo sapiens_hsa008302.26342028
11Chemical carcinogenesis_Homo sapiens_hsa052041.76879844
12Fatty acid biosynthesis_Homo sapiens_hsa000611.73355654
13Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.71866168
14Primary bile acid biosynthesis_Homo sapiens_hsa001201.68561930
15Glycerolipid metabolism_Homo sapiens_hsa005611.67617177
16Adipocytokine signaling pathway_Homo sapiens_hsa049201.63963269
17Tryptophan metabolism_Homo sapiens_hsa003801.59878462
18Prion diseases_Homo sapiens_hsa050201.56289964
19Arginine biosynthesis_Homo sapiens_hsa002201.54038470
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.53534699
21Malaria_Homo sapiens_hsa051441.50175981
22Caffeine metabolism_Homo sapiens_hsa002321.43956613
23beta-Alanine metabolism_Homo sapiens_hsa004101.43715186
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.37119955
25Fat digestion and absorption_Homo sapiens_hsa049751.36754623
26Butanoate metabolism_Homo sapiens_hsa006501.23913472
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19582124
28Pertussis_Homo sapiens_hsa051331.18572782
29Vascular smooth muscle contraction_Homo sapiens_hsa042701.16887918
30ECM-receptor interaction_Homo sapiens_hsa045121.16864107
31Cyanoamino acid metabolism_Homo sapiens_hsa004601.09745284
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.05902998
33Renin-angiotensin system_Homo sapiens_hsa046141.05734962
34Steroid hormone biosynthesis_Homo sapiens_hsa001401.03524774
35Bile secretion_Homo sapiens_hsa049761.03474754
36Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03079929
37Asthma_Homo sapiens_hsa053101.02543106
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02526258
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02467732
40Fatty acid metabolism_Homo sapiens_hsa012121.01500454
41Linoleic acid metabolism_Homo sapiens_hsa005910.99916722
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99050941
43Arachidonic acid metabolism_Homo sapiens_hsa005900.96744970
44Pyruvate metabolism_Homo sapiens_hsa006200.95748882
45Allograft rejection_Homo sapiens_hsa053300.94714812
46AMPK signaling pathway_Homo sapiens_hsa041520.93144327
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89057760
48Autoimmune thyroid disease_Homo sapiens_hsa053200.88874444
49Graft-versus-host disease_Homo sapiens_hsa053320.87589584
50Glycerophospholipid metabolism_Homo sapiens_hsa005640.87089742
51Renin secretion_Homo sapiens_hsa049240.83692787
52Arginine and proline metabolism_Homo sapiens_hsa003300.81823412
53ABC transporters_Homo sapiens_hsa020100.81082438
54Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72717449
55Insulin resistance_Homo sapiens_hsa049310.72076188
56Fatty acid elongation_Homo sapiens_hsa000620.71761081
57Focal adhesion_Homo sapiens_hsa045100.70573226
58Starch and sucrose metabolism_Homo sapiens_hsa005000.68631430
59Other glycan degradation_Homo sapiens_hsa005110.64289592
60Ovarian steroidogenesis_Homo sapiens_hsa049130.63310467
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60508706
62Viral myocarditis_Homo sapiens_hsa054160.60193321
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.59401992
64AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57484415
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55955507
66Type I diabetes mellitus_Homo sapiens_hsa049400.54773178
67Insulin signaling pathway_Homo sapiens_hsa049100.52266320
68Amoebiasis_Homo sapiens_hsa051460.51963606
692-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48723555
70Peroxisome_Homo sapiens_hsa041460.48394581
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47939469
72Propanoate metabolism_Homo sapiens_hsa006400.47542243
73Dorso-ventral axis formation_Homo sapiens_hsa043200.47326171
74Intestinal immune network for IgA production_Homo sapiens_hsa046720.46574364
75Dilated cardiomyopathy_Homo sapiens_hsa054140.44965768
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44462587
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.42549076
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.41184449
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.40547983
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38387246
81Toxoplasmosis_Homo sapiens_hsa051450.37334372
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.36561022
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36323161
84Platelet activation_Homo sapiens_hsa046110.35520649
85African trypanosomiasis_Homo sapiens_hsa051430.35132981
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.34226369
87Leishmaniasis_Homo sapiens_hsa051400.33044964
88Antigen processing and presentation_Homo sapiens_hsa046120.32617408
89Hematopoietic cell lineage_Homo sapiens_hsa046400.31288212
90Vitamin digestion and absorption_Homo sapiens_hsa049770.31199996
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30835912
92Phagosome_Homo sapiens_hsa041450.29592961
93Osteoclast differentiation_Homo sapiens_hsa043800.28918060
94Glutathione metabolism_Homo sapiens_hsa004800.28871665
95Circadian rhythm_Homo sapiens_hsa047100.28211995
96* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28166512
97Glucagon signaling pathway_Homo sapiens_hsa049220.27525656
98Jak-STAT signaling pathway_Homo sapiens_hsa046300.26674081
99Notch signaling pathway_Homo sapiens_hsa043300.26341129
100Carbon metabolism_Homo sapiens_hsa012000.25832424

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