CCL13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* eosinophil chemotaxis (GO:0048245)9.64525418
2* eosinophil migration (GO:0072677)8.52628431
3regulation of mononuclear cell migration (GO:0071675)7.60683046
4regulation of macrophage chemotaxis (GO:0010758)7.49449996
5cellular response to ethanol (GO:0071361)6.39818735
6positive regulation of mast cell activation involved in immune response (GO:0033008)6.24166735
7positive regulation of mast cell degranulation (GO:0043306)6.24166735
8adhesion of symbiont to host cell (GO:0044650)6.18122610
9virion attachment to host cell (GO:0019062)6.18122610
10adhesion of symbiont to host (GO:0044406)6.08445342
11positive regulation of myeloid leukocyte mediated immunity (GO:0002888)5.92710286
12positive regulation of mast cell activation (GO:0033005)5.74158027
13immunoglobulin mediated immune response (GO:0016064)5.64812429
14monocyte chemotaxis (GO:0002548)5.61925561
15phagocytosis, recognition (GO:0006910)5.40866827
16neutrophil activation involved in immune response (GO:0002283)5.04392302
17regulation of hypersensitivity (GO:0002883)5.01035154
18cellular extravasation (GO:0045123)4.95994701
19regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.87654020
20positive regulation of leukocyte degranulation (GO:0043302)4.85639039
21positive regulation of type 2 immune response (GO:0002830)4.61681005
22pinocytosis (GO:0006907)4.45910125
23regulation of T-helper 2 cell differentiation (GO:0045628)4.41652601
24positive regulation of cAMP-mediated signaling (GO:0043950)4.34300824
25regulation of cholesterol storage (GO:0010885)4.32134878
26regulation of mast cell degranulation (GO:0043304)4.25263788
27positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610814.24372782
28B cell mediated immunity (GO:0019724)4.24135290
29detection of molecule of bacterial origin (GO:0032490)4.17232311
30glycosphingolipid catabolic process (GO:0046479)4.10831278
31regulation of mast cell activation involved in immune response (GO:0033006)4.05022948
32regulation of mast cell activation (GO:0033003)3.92844165
33lymphocyte chemotaxis (GO:0048247)3.88081483
34regulation of T cell tolerance induction (GO:0002664)3.87129895
35regulation of lymphocyte chemotaxis (GO:1901623)3.84593442
36T cell migration (GO:0072678)3.83587185
37phagocytosis, engulfment (GO:0006911)3.79474025
38interferon-gamma-mediated signaling pathway (GO:0060333)3.75892509
39regulation of myeloid leukocyte mediated immunity (GO:0002886)3.71366501
40glycolipid catabolic process (GO:0019377)3.70350925
41positive regulation of antigen processing and presentation (GO:0002579)3.70346350
42amino sugar catabolic process (GO:0046348)3.62906335
43positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.62250591
44positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.59310427
45positive regulation of lymphocyte migration (GO:2000403)3.53975408
46negative regulation of interleukin-12 production (GO:0032695)3.53540510
47regulation of lymphocyte migration (GO:2000401)3.50950146
48histamine secretion (GO:0001821)3.47584729
49cellular response to thyroid hormone stimulus (GO:0097067)3.46570142
50myeloid dendritic cell differentiation (GO:0043011)3.42287390
51macrophage activation involved in immune response (GO:0002281)3.39748079
52regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.39710592
53regulation of apoptotic cell clearance (GO:2000425)3.37924429
54positive regulation of leukocyte chemotaxis (GO:0002690)3.36922298
55* granulocyte chemotaxis (GO:0071621)3.35574942
56ceramide catabolic process (GO:0046514)3.34072227
57adenosine receptor signaling pathway (GO:0001973)3.33340406
58regulation of antigen processing and presentation (GO:0002577)3.32044214
59positive regulation of regulated secretory pathway (GO:1903307)3.31021300
60positive regulation of macrophage cytokine production (GO:0060907)3.29227234
61positive regulation by symbiont of host defense response (GO:0052509)3.27548441
62modulation by symbiont of host defense response (GO:0052031)3.27548441
63modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.27548441
64modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.27548441
65positive regulation by organism of defense response of other organism involved in symbiotic interact3.27548441
66modulation by symbiont of host immune response (GO:0052553)3.27548441
67detection of external biotic stimulus (GO:0098581)3.26378893
68T cell mediated immunity (GO:0002456)3.25863181
69barbed-end actin filament capping (GO:0051016)3.25666344
70regulation of tolerance induction (GO:0002643)3.23196181
71T-helper 1 type immune response (GO:0042088)3.22772602
72positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.22663985
73* granulocyte migration (GO:0097530)3.20958801
74regulation of leukocyte degranulation (GO:0043300)3.19972302
75leukocyte mediated cytotoxicity (GO:0001909)3.19752589
76membrane invagination (GO:0010324)3.19141467
77regulation of granulocyte chemotaxis (GO:0071622)3.18970159
78positive regulation of prostaglandin secretion (GO:0032308)3.15983577
79regulation of inflammatory response to antigenic stimulus (GO:0002861)3.14236515
80folic acid transport (GO:0015884)3.13843170
81cellular response to interferon-gamma (GO:0071346)3.13730387
82regulation of type 2 immune response (GO:0002828)3.13131612
83regulation of interleukin-2 biosynthetic process (GO:0045076)3.13004285
84regulation of inositol phosphate biosynthetic process (GO:0010919)3.11137832
85N-acetylneuraminate metabolic process (GO:0006054)3.10679886
86lipopolysaccharide-mediated signaling pathway (GO:0031663)3.10563738
87myeloid dendritic cell activation (GO:0001773)3.08751764
88adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli3.06241330
89sphingolipid catabolic process (GO:0030149)3.05633020
90regulation of prostaglandin secretion (GO:0032306)3.04388999
91positive regulation of leukocyte migration (GO:0002687)3.04351189
92positive regulation of gamma-delta T cell activation (GO:0046645)3.01245800
93response to interferon-gamma (GO:0034341)3.00462344
94positive regulation of neutrophil migration (GO:1902624)2.96550924
95positive regulation of neutrophil chemotaxis (GO:0090023)2.96550924
96membrane lipid catabolic process (GO:0046466)2.93518068
97myeloid cell activation involved in immune response (GO:0002275)2.92241569
98intracellular pH reduction (GO:0051452)2.91895329
99positive regulation of acute inflammatory response (GO:0002675)2.91817090
100type I interferon signaling pathway (GO:0060337)2.89803759

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.79472516
2IRF8_21731497_ChIP-ChIP_J774_Mouse5.43069672
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.39122843
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.84288819
5NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.96535004
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.70008692
7GATA1_22025678_ChIP-Seq_K562_Human3.62837736
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.62178324
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.58456744
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.15678587
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.00218168
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.63338641
13VDR_24787735_ChIP-Seq_THP-1_Human2.49476508
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.42422824
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.41722535
16SPI1_23127762_ChIP-Seq_K562_Human2.38625388
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.33639701
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.31802591
19SPI1_23547873_ChIP-Seq_NB4_Human2.23301534
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.01282969
21PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse2.00309144
22STAT4_19710469_ChIP-ChIP_TH1__Mouse1.99059260
23SCL_19346495_ChIP-Seq_HPC-7_Human1.93934711
24RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.89799862
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.88359444
26PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.86437308
27VDR_24763502_ChIP-Seq_THP-1_Human1.79911958
28CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.70737804
29STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.69293086
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68342136
31CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.61300323
32CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.58501281
33MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.55675884
34PU_27001747_Chip-Seq_BMDM_Mouse1.55467208
35LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.54775791
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53944849
37GATA2_21666600_ChIP-Seq_HMVEC_Human1.46698107
38CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.46495848
39LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.46370079
40SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44862025
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41419341
42TFEB_21752829_ChIP-Seq_HELA_Human1.38879829
43CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34560311
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.34264267
45PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32924594
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.27641641
47NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22881042
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.22795882
49SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22464396
50STAT1_20625510_ChIP-Seq_HELA_Human1.22055670
51PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21026095
52EGR1_19032775_ChIP-ChIP_M12_Human1.16138392
53FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15962972
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14585181
55SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.13580843
56RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13006285
57* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09321613
58GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09299023
59CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03867960
60SOX2_20726797_ChIP-Seq_SW620_Human1.03573110
61TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01103656
62MYB_26560356_Chip-Seq_TH2_Human1.00483661
63GATA3_26560356_Chip-Seq_TH2_Human0.95644921
64STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95002322
65GATA1_19941826_ChIP-Seq_K562_Human0.92622615
66RXR_22158963_ChIP-Seq_LIVER_Mouse0.92371682
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.91484506
68FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.91454113
69GATA2_19941826_ChIP-Seq_K562_Human0.89639927
70RUNX_20019798_ChIP-Seq_JUKART_Human0.88710747
71GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86816427
72GATA3_27048872_Chip-Seq_THYMUS_Human0.86798949
73ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86273430
74VDR_21846776_ChIP-Seq_THP-1_Human0.85093050
75TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.83797600
76LXR_22158963_ChIP-Seq_LIVER_Mouse0.83769852
77SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82282204
78SPI1_20517297_ChIP-Seq_HL60_Human0.81978594
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.80705841
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.80681262
81LXR_22292898_ChIP-Seq_THP-1_Human0.80106182
82GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80086942
83GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78290153
84GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77373903
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.76797270
86VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.76432865
87PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.76230775
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.74012695
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.73817087
90PPARA_22158963_ChIP-Seq_LIVER_Mouse0.73752337
91VDR_22108803_ChIP-Seq_LS180_Human0.73342866
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.70296556
93EGR1_23403033_ChIP-Seq_LIVER_Mouse0.70115239
94ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.69914346
95PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.69365610
96ELF1_20517297_ChIP-Seq_JURKAT_Human0.68077979
97SMRT_27268052_Chip-Seq_Bcells_Human0.66842567
98NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66599780
99NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66599780
100P63_26484246_Chip-Seq_KERATINOCYTES_Human0.65228694

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to4.22365921
2MP0001835_abnormal_antigen_presentation3.89246861
3MP0009840_abnormal_foam_cell3.87690043
4MP0002148_abnormal_hypersensitivity_rea3.62317811
5MP0003191_abnormal_cellular_cholesterol3.59444696
6MP0006082_CNS_inflammation3.54765890
7MP0003172_abnormal_lysosome_physiology3.33925472
8MP0005058_abnormal_lysosome_morphology3.21603896
9MP0000569_abnormal_digit_pigmentation3.02510801
10MP0000343_altered_response_to3.00953344
11MP0002419_abnormal_innate_immunity2.87556535
12MP0009785_altered_susceptibility_to2.79012645
13MP0002277_abnormal_respiratory_mucosa2.71229698
14MP0005025_abnormal_response_to2.66637159
15MP0005000_abnormal_immune_tolerance2.64857756
16MP0001790_abnormal_immune_system2.57397565
17MP0005387_immune_system_phenotype2.57397565
18MP0002452_abnormal_antigen_presenting2.43809382
19MP0003183_abnormal_peptide_metabolism2.43681930
20MP0005167_abnormal_blood-brain_barrier2.41046658
21MP0000604_amyloidosis2.39218842
22MP0002723_abnormal_immune_serum2.29745171
23MP0003436_decreased_susceptibility_to2.21541988
24MP0001800_abnormal_humoral_immune2.16384397
25MP0003724_increased_susceptibility_to2.15484915
26MP0000015_abnormal_ear_pigmentation2.07854435
27MP0005174_abnormal_tail_pigmentation2.07284073
28MP0001845_abnormal_inflammatory_respons1.93914203
29MP0000920_abnormal_myelination1.91839102
30MP0001819_abnormal_immune_cell1.88854599
31MP0002420_abnormal_adaptive_immunity1.84751256
32MP0003300_gastrointestinal_ulcer1.82964140
33MP0005464_abnormal_platelet_physiology1.82393565
34MP0000685_abnormal_immune_system1.73650888
35MP0008469_abnormal_protein_level1.70523367
36MP0001533_abnormal_skeleton_physiology1.67114447
37MP0003075_altered_response_to1.59882728
38MP0009764_decreased_sensitivity_to1.58946445
39MP0008004_abnormal_stomach_pH1.52028357
40MP0005310_abnormal_salivary_gland1.48872695
41MP0003448_altered_tumor_morphology1.43432602
42MP0005365_abnormal_bile_salt1.42407941
43MP0009333_abnormal_splenocyte_physiolog1.39675963
44MP0002998_abnormal_bone_remodeling1.39241446
45MP0002139_abnormal_hepatobiliary_system1.34986801
46MP0003303_peritoneal_inflammation1.32013255
47MP0000716_abnormal_immune_system1.22894917
48MP0004947_skin_inflammation1.20018835
49MP0002405_respiratory_system_inflammati1.16318443
50MP0009763_increased_sensitivity_to1.13471394
51MP0006054_spinal_hemorrhage1.13264057
52MP0005360_urolithiasis1.10669986
53MP0000371_diluted_coat_color1.09282088
54MP0001727_abnormal_embryo_implantation1.07426800
55MP0003690_abnormal_glial_cell1.06343048
56MP0003828_pulmonary_edema1.04199025
57MP0005647_abnormal_sex_gland1.03623838
58MP0000858_altered_metastatic_potential0.96104869
59MP0005166_decreased_susceptibility_to0.96021440
60MP0002295_abnormal_pulmonary_circulatio0.96020026
61MP0010234_abnormal_vibrissa_follicle0.94986214
62MP0005584_abnormal_enzyme/coenzyme_acti0.94833310
63MP0001853_heart_inflammation0.94409339
64MP0005164_abnormal_response_to0.92566987
65MP0002429_abnormal_blood_cell0.91381453
66MP0003279_aneurysm0.91061455
67MP0000249_abnormal_blood_vessel0.88067559
68MP0002095_abnormal_skin_pigmentation0.88063925
69MP0010155_abnormal_intestine_physiology0.87892256
70MP0002398_abnormal_bone_marrow0.87856497
71MP0000689_abnormal_spleen_morphology0.86198453
72MP0001986_abnormal_taste_sensitivity0.84897676
73MP0008875_abnormal_xenobiotic_pharmacok0.84447636
74MP0003806_abnormal_nucleotide_metabolis0.81522715
75MP0009115_abnormal_fat_cell0.81290220
76MP0001851_eye_inflammation0.78131886
77MP0008260_abnormal_autophagy0.76758311
78MP0009643_abnormal_urine_homeostasis0.75787513
79MP0002136_abnormal_kidney_physiology0.75049991
80MP0010307_abnormal_tumor_latency0.74711390
81MP0000609_abnormal_liver_physiology0.68011062
82MP0003315_abnormal_perineum_morphology0.67386478
83MP0005165_increased_susceptibility_to0.67229858
84MP0008874_decreased_physiological_sensi0.67058214
85MP0004883_abnormal_blood_vessel0.66260649
86MP0005670_abnormal_white_adipose0.64292419
87MP0005390_skeleton_phenotype0.63543822
88MP0005319_abnormal_enzyme/_coenzyme0.63383068
89MP0009765_abnormal_xenobiotic_induced0.63035574
90MP0001324_abnormal_eye_pigmentation0.62619814
91MP0003638_abnormal_response/metabolism_0.61861239
92MP0003632_abnormal_nervous_system0.61674216
93MP0002971_abnormal_brown_adipose0.61072456
94MP0000465_gastrointestinal_hemorrhage0.59786352
95MP0004742_abnormal_vestibular_system0.58476656
96MP0001542_abnormal_bone_strength0.58270112
97MP0002722_abnormal_immune_system0.57816363
98MP0002896_abnormal_bone_mineralization0.56456759
99MP0003795_abnormal_bone_structure0.56196646
100MP0002090_abnormal_vision0.55914220

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)9.37494749
2Recurrent bacterial skin infections (HP:0005406)7.42409478
3Spontaneous hematomas (HP:0007420)7.16327769
4Recurrent abscess formation (HP:0002722)6.42203585
5Thick nail (HP:0001805)6.14868342
6Pustule (HP:0200039)5.95831105
7Vacuolated lymphocytes (HP:0001922)5.93243567
8Abnormality of liposaccharide metabolism (HP:0010968)5.72056311
9Abnormality of glycosphingolipid metabolism (HP:0004343)5.72056311
10Abnormality of glycolipid metabolism (HP:0010969)5.72056311
11Glomerulonephritis (HP:0000099)5.43643698
12Premature loss of primary teeth (HP:0006323)5.04182709
13Osteolytic defects of the phalanges of the hand (HP:0009771)4.76228254
14Osteolytic defects of the hand bones (HP:0009699)4.76228254
15Joint hemorrhage (HP:0005261)4.60393623
16Abnormality of macrophages (HP:0004311)4.45375206
17Recurrent skin infections (HP:0001581)4.41722421
18Dysostosis multiplex (HP:0000943)4.20369901
19Complement deficiency (HP:0004431)4.18828927
20Disinhibition (HP:0000734)4.16722386
21Periodontitis (HP:0000704)4.13983111
22Axonal loss (HP:0003447)4.05753960
23Gingivitis (HP:0000230)4.04469263
24Agnosia (HP:0010524)3.94255591
25Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.72162295
26Mutism (HP:0002300)3.58220635
27Abnormality of polysaccharide metabolism (HP:0011012)3.51990509
28Abnormality of glycosaminoglycan metabolism (HP:0004371)3.51990509
29Abnormality of mucopolysaccharide metabolism (HP:0011020)3.51990509
30Upper motor neuron abnormality (HP:0002127)3.41830424
31Mucopolysacchariduria (HP:0008155)3.37315312
32Urinary glycosaminoglycan excretion (HP:0003541)3.37315312
33Abnormality of complement system (HP:0005339)3.15631619
34Recurrent cutaneous fungal infections (HP:0011370)3.15483618
35Chronic mucocutaneous candidiasis (HP:0002728)3.15483618
36Nuclear cataract (HP:0100018)3.02853679
37Albinism (HP:0001022)3.01331826
38Prostate neoplasm (HP:0100787)2.95458743
39Increased cerebral lipofuscin (HP:0011813)2.87997926
40Eczematoid dermatitis (HP:0000976)2.87890138
41Recurrent gram-negative bacterial infections (HP:0005420)2.83404030
42Loss of speech (HP:0002371)2.79682057
43Cheilitis (HP:0100825)2.75611981
44Nephritis (HP:0000123)2.63727150
45Increased neuronal autofluorescent lipopigment (HP:0002074)2.62817992
46Pathologic fracture (HP:0002756)2.60851577
47Inappropriate behavior (HP:0000719)2.60665777
48Abnormality of the alveolar ridges (HP:0006477)2.58166321
49Abnormality of the prostate (HP:0008775)2.52397176
50Hemoptysis (HP:0002105)2.51873031
51Palmoplantar hyperkeratosis (HP:0000972)2.50253151
52Personality changes (HP:0000751)2.34797496
53Palmar hyperkeratosis (HP:0010765)2.32314932
54Basal ganglia calcification (HP:0002135)2.30377656
55Obstructive lung disease (HP:0006536)2.19935753
56Chronic obstructive pulmonary disease (HP:0006510)2.19935753
57Esophageal varix (HP:0002040)2.18259813
58Abnormality of the common coagulation pathway (HP:0010990)2.17799675
59Protuberant abdomen (HP:0001538)2.15292505
60Mediastinal lymphadenopathy (HP:0100721)2.15164023
61Recurrent fungal infections (HP:0002841)2.13131942
62Apathy (HP:0000741)2.10899351
63Abnormality of the vasculature of the conjunctiva (HP:0008054)2.09364456
64Zonular cataract (HP:0010920)2.09155382
65Hydroxyprolinuria (HP:0003080)2.06746228
66Abnormality of proline metabolism (HP:0010907)2.06746228
67Diminished motivation (HP:0000745)2.06407438
68Vertebral compression fractures (HP:0002953)2.06255200
69Abnormality of primary teeth (HP:0006481)2.02007162
70Tetraparesis (HP:0002273)1.99207388
71Epistaxis (HP:0000421)1.98159538
72Neoplasm of head and neck (HP:0012288)1.97624672
73Esophageal neoplasm (HP:0100751)1.97624672
74Urticaria (HP:0001025)1.96413740
75Progressive visual loss (HP:0000529)1.95324916
76Plantar hyperkeratosis (HP:0007556)1.92448512
77Asymmetric septal hypertrophy (HP:0001670)1.91659122
78Peripheral demyelination (HP:0011096)1.90782703
79Bone cyst (HP:0012062)1.90768053
80Neuronal loss in central nervous system (HP:0002529)1.89823395
81Bone pain (HP:0002653)1.89737281
82Abnormality of the basal ganglia (HP:0002134)1.84601331
83Mucosal telangiectasiae (HP:0100579)1.81271697
84Pulmonary infiltrates (HP:0002113)1.79725769
85Recurrent pneumonia (HP:0006532)1.77003013
86Myocardial infarction (HP:0001658)1.74470768
87Hepatosplenomegaly (HP:0001433)1.73201801
88Segmental peripheral demyelination/remyelination (HP:0003481)1.71985559
89Memory impairment (HP:0002354)1.71375506
90Meningitis (HP:0001287)1.71286656
91Neurofibrillary tangles (HP:0002185)1.69932933
92Purpura (HP:0000979)1.69553524
93Ovoid vertebral bodies (HP:0003300)1.64852796
94Metaphyseal irregularity (HP:0003025)1.63804420
95Dementia (HP:0000726)1.63649671
96Hematochezia (HP:0002573)1.63210943
97Amyloidosis (HP:0011034)1.61430706
98Malnutrition (HP:0004395)1.60207926
99Myositis (HP:0100614)1.59604718
100Cardiomegaly (HP:0001640)1.59066730

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TYK23.77165752
2CSF1R2.70134198
3MAP3K142.55218060
4CAMK1D2.42068210
5EPHB22.40175635
6TESK22.31012803
7CAMKK22.21981716
8JAK12.08965016
9RIPK42.06537994
10BLK10.5603958
11CAMK1G1.90878646
12SYK1.87526926
13TGFBR21.69256616
14ERN11.68877850
15LYN1.63867084
16JAK31.57991906
17BMPR21.56864843
18MAP3K131.55264293
19PDK21.53655296
20KIT1.48389064
21PIK3CG1.47448405
22CSK1.42797623
23CDK61.28069975
24FES1.25027815
25MAP3K31.22099811
26FGR1.17952194
27KSR11.15373752
28MAP2K31.14739921
29ZAP701.06646516
30GRK71.01515747
31MAPKAPK50.97808663
32TXK0.94754582
33ITK0.88678669
34IKBKB0.88657680
35TRPM70.88251075
36BTK0.87593150
37MAPKAPK30.87013099
38YES10.82928459
39NEK90.81183846
40LCK0.80199009
41ADRBK10.77857691
42TBK10.76287148
43MAP3K10.74270637
44ADRBK20.71762075
45JAK20.71066020
46TAF10.70402414
47HCK0.67490421
48CAMKK10.64432312
49MAP4K10.64249778
50ACVR1B0.62771565
51MATK0.61349728
52PRKCQ0.60778513
53PDPK10.59251318
54IRAK40.58574777
55MOS0.58548497
56RPS6KA20.58154112
57EGFR0.57209369
58TEC0.56644287
59IRAK30.56554321
60IKBKE0.55687743
61PRKG20.55574449
62FYN0.55458295
63SGK20.54538160
64CDK90.54124205
65ABL20.53676015
66DMPK0.52759689
67SGK30.51542559
68ARAF0.50137629
69ABL10.49550217
70KSR20.47314518
71PDK10.46946467
72TAOK30.45584341
73MAP3K110.43531976
74MAP3K20.41966115
75PRKCD0.41964737
76ERBB20.41048437
77PBK0.40106013
78PRKG10.39148137
79PIK3CA0.37882832
80CAMK40.34293172
81IGF1R0.32094967
82MAPK120.31556750
83TNK20.31223946
84SCYL20.30037036
85INSR0.28822216
86RPS6KL10.28681950
87RPS6KC10.28681950
88MAP2K60.28143570
89NTRK30.27948558
90MAP3K40.26509028
91DAPK20.26180997
92SRC0.25477416
93PIM20.25132587
94TTN0.25122554
95MAP3K80.23907101
96PRKCA0.23872154
97CAMK2A0.23653971
98PRKAA20.23179498
99SMG10.22991137
100RPS6KA60.22550669

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051505.63757853
2Asthma_Homo sapiens_hsa053104.24762368
3Allograft rejection_Homo sapiens_hsa053303.90537979
4Autoimmune thyroid disease_Homo sapiens_hsa053203.60159133
5Graft-versus-host disease_Homo sapiens_hsa053323.45771333
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.22768511
7Type I diabetes mellitus_Homo sapiens_hsa049403.00465089
8Rheumatoid arthritis_Homo sapiens_hsa053232.96013512
9Lysosome_Homo sapiens_hsa041422.94090095
10Leishmaniasis_Homo sapiens_hsa051402.79967544
11Other glycan degradation_Homo sapiens_hsa005112.69058771
12Phagosome_Homo sapiens_hsa041452.57399992
13Tuberculosis_Homo sapiens_hsa051522.32537838
14Viral myocarditis_Homo sapiens_hsa054162.25007701
15Glycosaminoglycan degradation_Homo sapiens_hsa005312.19925749
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.15229240
17Antigen processing and presentation_Homo sapiens_hsa046122.12880288
18Complement and coagulation cascades_Homo sapiens_hsa046102.08694453
19Osteoclast differentiation_Homo sapiens_hsa043801.92371545
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.86581451
21Hematopoietic cell lineage_Homo sapiens_hsa046401.70985838
22* Chemokine signaling pathway_Homo sapiens_hsa040621.55587566
23Pertussis_Homo sapiens_hsa051331.52591817
24Influenza A_Homo sapiens_hsa051641.37737665
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.35454902
26Collecting duct acid secretion_Homo sapiens_hsa049661.30429609
27* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.25788831
28Toxoplasmosis_Homo sapiens_hsa051451.24222856
29Prion diseases_Homo sapiens_hsa050201.13457980
30Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11729698
31Systemic lupus erythematosus_Homo sapiens_hsa053221.11049955
32Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.97065595
33Malaria_Homo sapiens_hsa051440.92089320
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88770080
35Sphingolipid metabolism_Homo sapiens_hsa006000.87885581
36* NF-kappa B signaling pathway_Homo sapiens_hsa040640.79665528
37Herpes simplex infection_Homo sapiens_hsa051680.77388418
38Measles_Homo sapiens_hsa051620.76968363
39NOD-like receptor signaling pathway_Homo sapiens_hsa046210.76893787
40Synaptic vesicle cycle_Homo sapiens_hsa047210.75347227
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73873012
42Vibrio cholerae infection_Homo sapiens_hsa051100.73641478
43B cell receptor signaling pathway_Homo sapiens_hsa046620.72007699
44Mineral absorption_Homo sapiens_hsa049780.66124813
45Galactose metabolism_Homo sapiens_hsa000520.65285532
46Legionellosis_Homo sapiens_hsa051340.60707636
47TNF signaling pathway_Homo sapiens_hsa046680.59436242
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57951295
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57741373
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54558727
51Salmonella infection_Homo sapiens_hsa051320.54019244
52Sphingolipid signaling pathway_Homo sapiens_hsa040710.49172270
53Apoptosis_Homo sapiens_hsa042100.48882780
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47734626
55Sulfur metabolism_Homo sapiens_hsa009200.44763616
56Caffeine metabolism_Homo sapiens_hsa002320.44581147
57Histidine metabolism_Homo sapiens_hsa003400.44162869
58Platelet activation_Homo sapiens_hsa046110.42714029
59Endocytosis_Homo sapiens_hsa041440.41996775
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41847592
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40101899
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38959400
63African trypanosomiasis_Homo sapiens_hsa051430.37973400
64Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.36696037
65Shigellosis_Homo sapiens_hsa051310.34525329
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32993745
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.31891649
68Hepatitis C_Homo sapiens_hsa051600.31739225
69Fatty acid elongation_Homo sapiens_hsa000620.31453048
70SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29110179
71Arachidonic acid metabolism_Homo sapiens_hsa005900.28400925
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.28084447
73Amoebiasis_Homo sapiens_hsa051460.27908079
74Ether lipid metabolism_Homo sapiens_hsa005650.25704463
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.25012432
76Glutathione metabolism_Homo sapiens_hsa004800.23244857
77Steroid biosynthesis_Homo sapiens_hsa001000.21982642
78Renin-angiotensin system_Homo sapiens_hsa046140.21519936
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20155269
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.19107452
81Linoleic acid metabolism_Homo sapiens_hsa005910.18688723
82PPAR signaling pathway_Homo sapiens_hsa033200.18081603
83Renin secretion_Homo sapiens_hsa049240.16847338
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.15430962
85Epstein-Barr virus infection_Homo sapiens_hsa051690.14386647
86HTLV-I infection_Homo sapiens_hsa051660.11930658
87GnRH signaling pathway_Homo sapiens_hsa049120.10087922
88Primary immunodeficiency_Homo sapiens_hsa053400.09715882
89Prolactin signaling pathway_Homo sapiens_hsa049170.09402857
90Vitamin digestion and absorption_Homo sapiens_hsa049770.08250647
91T cell receptor signaling pathway_Homo sapiens_hsa046600.07394631
92AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.07352928
93Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.06474171
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.05856688
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.05766215
96Ovarian steroidogenesis_Homo sapiens_hsa049130.04601082
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.03903175
98Fat digestion and absorption_Homo sapiens_hsa049750.03388145
99Arginine and proline metabolism_Homo sapiens_hsa003300.01971045
100Hepatitis B_Homo sapiens_hsa051610.01535773

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