CCL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of immunoglobulin secretion (GO:0051023)8.67037383
2positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)8.58990515
3regulation of regulatory T cell differentiation (GO:0045589)8.54734281
4regulation of podosome assembly (GO:0071801)8.47230960
5positive regulation of immunoglobulin mediated immune response (GO:0002891)8.29582052
6positive regulation of B cell mediated immunity (GO:0002714)8.29582052
7positive regulation of T cell chemotaxis (GO:0010820)8.29331481
8regulation of T cell chemotaxis (GO:0010819)8.29331481
9positive regulation of isotype switching (GO:0045830)7.69062538
10regulation of syncytium formation by plasma membrane fusion (GO:0060142)6.69911461
11regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)6.64446340
12positive regulation of DNA recombination (GO:0045911)6.60620297
13positive regulation of T cell cytokine production (GO:0002726)6.50247229
14regulation of immunoglobulin mediated immune response (GO:0002889)6.41698907
15regulation of interleukin-12 biosynthetic process (GO:0045075)6.36601564
16regulation of lymphocyte chemotaxis (GO:1901623)6.29090565
17positive regulation of immunoglobulin production (GO:0002639)6.21137172
18regulation of B cell mediated immunity (GO:0002712)6.20830964
19negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)6.16525510
20regulation of response to tumor cell (GO:0002834)5.99650956
21positive regulation of response to tumor cell (GO:0002836)5.99650956
22positive regulation of immune response to tumor cell (GO:0002839)5.99650956
23regulation of immune response to tumor cell (GO:0002837)5.99650956
24positive regulation of humoral immune response (GO:0002922)5.99111994
25eosinophil chemotaxis (GO:0048245)5.96865789
26activated T cell proliferation (GO:0050798)5.86589017
27cellular extravasation (GO:0045123)5.74577045
28positive regulation of macrophage derived foam cell differentiation (GO:0010744)5.71390567
29regulation of isotype switching (GO:0045191)5.65340759
30regulation of chronic inflammatory response (GO:0002676)5.59201200
31lipopolysaccharide-mediated signaling pathway (GO:0031663)5.55308404
32regulation of immunoglobulin production (GO:0002637)5.54777377
33cellular response to ethanol (GO:0071361)5.52571759
34myeloid dendritic cell differentiation (GO:0043011)5.49755458
35positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)5.34372463
36NIK/NF-kappaB signaling (GO:0038061)5.33865043
37eosinophil migration (GO:0072677)5.31870422
38negative regulation of T cell mediated immunity (GO:0002710)5.30678272
39negative regulation of B cell apoptotic process (GO:0002903)5.27204891
40positive regulation of interleukin-17 production (GO:0032740)5.21563949
41positive regulation of alpha-beta T cell proliferation (GO:0046641)5.11395746
42positive regulation of inflammatory response to antigenic stimulus (GO:0002863)5.06875640
43regulation of vitamin D biosynthetic process (GO:0060556)5.02590091
44positive regulation of activated T cell proliferation (GO:0042104)4.96688210
45positive regulation of lymphocyte mediated immunity (GO:0002708)4.91200177
46monocyte chemotaxis (GO:0002548)4.86208715
47regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)4.85655052
48positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)4.85655052
49regulation of mononuclear cell migration (GO:0071675)4.79444419
50myeloid dendritic cell activation (GO:0001773)4.75592743
51positive regulation of natural killer cell mediated immunity (GO:0002717)4.75136431
52positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.75136431
53regulation of alpha-beta T cell proliferation (GO:0046640)4.74599517
54germinal center formation (GO:0002467)4.65873735
55positive regulation of type 2 immune response (GO:0002830)4.63613586
56regulation of tyrosine phosphorylation of STAT protein (GO:0042509)4.61730956
57positive regulation of leukocyte mediated cytotoxicity (GO:0001912)4.57817176
58positive regulation of cell killing (GO:0031343)4.54542668
59positive regulation of heat generation (GO:0031652)4.48847958
60regulation of vitamin metabolic process (GO:0030656)4.45313074
61positive regulation of JAK-STAT cascade (GO:0046427)4.42963054
62positive regulation of osteoclast differentiation (GO:0045672)4.42927613
63regulation of fever generation (GO:0031620)4.42014268
64negative regulation of interleukin-12 production (GO:0032695)4.40006116
65regulation of T cell cytokine production (GO:0002724)4.38692496
66osteoclast differentiation (GO:0030316)4.37522194
67positive regulation of gamma-delta T cell activation (GO:0046645)4.33110952
68regulation of natural killer cell mediated immunity (GO:0002715)4.26527792
69regulation of natural killer cell mediated cytotoxicity (GO:0042269)4.26527792
70T cell migration (GO:0072678)4.23313526
71regulation of macrophage chemotaxis (GO:0010758)4.20857643
72positive regulation of T cell mediated cytotoxicity (GO:0001916)4.19946063
73positive regulation of leukocyte mediated immunity (GO:0002705)4.19239445
74positive regulation of lymphocyte migration (GO:2000403)4.18636258
75negative regulation of cytokine production involved in immune response (GO:0002719)4.14288296
76cellular response to interleukin-15 (GO:0071350)4.10072406
77positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.07565618
78regulation of interleukin-17 production (GO:0032660)4.04318843
79positive regulation of T-helper 1 type immune response (GO:0002827)4.03322548
80positive regulation of T cell migration (GO:2000406)4.01390541
81regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.98398349
82positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.95711357
83response to interleukin-15 (GO:0070672)3.94588205
84T cell proliferation (GO:0042098)3.94235030
85modulation of growth of symbiont involved in interaction with host (GO:0044144)3.93519534
86regulation of growth of symbiont in host (GO:0044126)3.93519534
87negative regulation of growth of symbiont in host (GO:0044130)3.93519534
88negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.93519534
89regulation of monocyte differentiation (GO:0045655)3.91306484
90regulation of leukocyte mediated cytotoxicity (GO:0001910)3.91005377
91positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.90977241
92regulation of lymphocyte mediated immunity (GO:0002706)3.88695107
93leukocyte aggregation (GO:0070486)3.86980892
94regulation of cell killing (GO:0031341)3.84766875
95regulation of lymphocyte migration (GO:2000401)3.83994955
96regulation of activated T cell proliferation (GO:0046006)3.81538798
97decidualization (GO:0046697)3.81099071
98regulation of gamma-delta T cell differentiation (GO:0045586)3.80549089
99positive regulation of adaptive immune response based on somatic recombination of immune receptors b3.76621465
100negative T cell selection (GO:0043383)3.75204759
101positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.73796885
102positive regulation of production of molecular mediator of immune response (GO:0002702)3.70719643
103negative regulation of alpha-beta T cell activation (GO:0046636)3.70510484
104regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)3.69264340
105cellular response to nicotine (GO:0071316)3.68276726
106negative regulation of lymphocyte mediated immunity (GO:0002707)3.66466934
107regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.61495341
108positive regulation of myeloid leukocyte differentiation (GO:0002763)3.60418333
109negative regulation of myeloid cell apoptotic process (GO:0033033)3.59129565
110tyrosine phosphorylation of STAT protein (GO:0007260)3.58576687
111negative regulation of production of molecular mediator of immune response (GO:0002701)3.57543544
112positive regulation of adaptive immune response (GO:0002821)3.56357133
113lymphocyte chemotaxis (GO:0048247)3.53563639
114regulation of T cell mediated cytotoxicity (GO:0001914)3.53134433
115regulation of prostaglandin secretion (GO:0032306)3.51823007
116response to peptidoglycan (GO:0032494)3.48456929
117positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.44762756
118granulocyte chemotaxis (GO:0071621)3.44073701
119antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.42790034
120antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.42790034
121regulation of gamma-delta T cell activation (GO:0046643)3.42759890
122negative regulation of interleukin-2 production (GO:0032703)3.42695003
123regulation of B cell apoptotic process (GO:0002902)3.42592987
124regulation of T cell migration (GO:2000404)3.42546737
125negative thymic T cell selection (GO:0045060)3.41907357
126positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.40724697
127positive regulation of chemokine biosynthetic process (GO:0045080)3.36597123
128regulation of T-helper 1 type immune response (GO:0002825)3.35253115
129positive regulation of organelle assembly (GO:1902117)3.33760032
130regulation of heat generation (GO:0031650)3.31254985
131regulation of T-helper 1 cell differentiation (GO:0045625)3.29311897
132granulocyte migration (GO:0097530)3.29177829
133positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.24080270
134lymphocyte migration (GO:0072676)3.22657848
135negative regulation of interleukin-17 production (GO:0032700)3.17410014
136positive regulation of macrophage differentiation (GO:0045651)3.15557552
137regulation of B cell receptor signaling pathway (GO:0050855)3.14005283
138positive regulation of NF-kappaB import into nucleus (GO:0042346)3.13527982
139regulation of membrane protein ectodomain proteolysis (GO:0051043)3.03971945
140positive regulation of prostaglandin secretion (GO:0032308)3.03296757
141neutrophil chemotaxis (GO:0030593)3.02803359
142regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.97325247
143neutrophil migration (GO:1990266)2.94824965
144positive regulation of macrophage activation (GO:0043032)2.93306054
145positive regulation of leukocyte chemotaxis (GO:0002690)2.93300846
146regulation of histone phosphorylation (GO:0033127)2.87966900
147negative regulation of erythrocyte differentiation (GO:0045647)2.80649481
148macrophage differentiation (GO:0030225)2.80239572
149Arp2/3 complex-mediated actin nucleation (GO:0034314)2.79307362
150cellular response to lipopolysaccharide (GO:0071222)2.78959024
151positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.77862422
152positive regulation of acute inflammatory response (GO:0002675)2.77815077
153membrane protein intracellular domain proteolysis (GO:0031293)2.77555658
154neutrophil mediated immunity (GO:0002446)2.77366572
155positive regulation of myeloid cell differentiation (GO:0045639)2.74364911
156regulation of chemokine biosynthetic process (GO:0045073)2.71920497
157cellular response to type I interferon (GO:0071357)2.71289184
158type I interferon signaling pathway (GO:0060337)2.71289184
159positive regulation of transcription factor import into nucleus (GO:0042993)2.70931058
160necroptotic process (GO:0070266)2.70681617
161response to protozoan (GO:0001562)2.70276340
162positive regulation of macrophage cytokine production (GO:0060907)2.70084559
163regulation of interleukin-2 biosynthetic process (GO:0045076)2.69948158
164positive regulation of granulocyte differentiation (GO:0030854)2.69754098
165response to type I interferon (GO:0034340)2.69202309
166cellular response to molecule of bacterial origin (GO:0071219)2.67124246
167positive regulation of keratinocyte differentiation (GO:0045618)2.60581573
168positive regulation of B cell proliferation (GO:0030890)2.59005616
169T-helper 1 type immune response (GO:0042088)2.58773065
170regulation of granulocyte chemotaxis (GO:0071622)2.58321544
171negative regulation of monooxygenase activity (GO:0032769)2.57929127
172response to muramyl dipeptide (GO:0032495)2.57744848
173regulation of macrophage differentiation (GO:0045649)2.55524132
174DNA integration (GO:0015074)2.54819878
175interferon-gamma-mediated signaling pathway (GO:0060333)2.54665468
176positive regulation of leukocyte migration (GO:0002687)2.54377002
177myeloid leukocyte migration (GO:0097529)2.54317169
178positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.54043853
179regulation of hypersensitivity (GO:0002883)2.48690115
180regulation of necroptotic process (GO:0060544)2.47796211
181toll-like receptor 3 signaling pathway (GO:0034138)2.47262530
182negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.47195490
183TRIF-dependent toll-like receptor signaling pathway (GO:0035666)2.46359808
184positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)12.2476461
185regulation of isotype switching to IgG isotypes (GO:0048302)10.1731644
186regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)10.1265951

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse9.58844847
2BP1_19119308_ChIP-ChIP_Hs578T_Human7.42172739
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.56346886
4STAT4_19710469_ChIP-ChIP_TH1__Mouse4.59325922
5STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.53952984
6EGR1_19374776_ChIP-ChIP_THP-1_Human4.18298075
7NOTCH1_21737748_ChIP-Seq_TLL_Human3.77014543
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.61194658
9E2F7_22180533_ChIP-Seq_HELA_Human3.51244356
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.45814778
11RUNX_20019798_ChIP-Seq_JUKART_Human3.29750725
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.28618787
13* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.06760747
14MYC_22102868_ChIP-Seq_BL_Human2.91012731
15* MYB_26560356_Chip-Seq_TH2_Human2.84546895
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.77633191
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.70845911
18GATA1_22025678_ChIP-Seq_K562_Human2.58252007
19MAF_26560356_Chip-Seq_TH1_Human2.55696033
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.49321777
21FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.49026708
22* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.42836297
23MYB_26560356_Chip-Seq_TH1_Human2.39504791
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.13629394
25IRF8_21731497_ChIP-ChIP_J774_Mouse2.07437497
26* GATA3_27048872_Chip-Seq_THYMUS_Human2.07411273
27SCL_19346495_ChIP-Seq_HPC-7_Human1.92952243
28MAF_26560356_Chip-Seq_TH2_Human1.90373543
29EGR1_19032775_ChIP-ChIP_M12_Human1.87376622
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.85017184
31MYB_21317192_ChIP-Seq_ERMYB_Mouse1.76587232
32* UTX_26944678_Chip-Seq_JUKART_Human1.75738933
33KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.69223297
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.65457873
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59350310
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54702004
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.53592979
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51940539
39MYC_18555785_ChIP-Seq_MESCs_Mouse1.49847178
40VDR_24763502_ChIP-Seq_THP-1_Human1.48178720
41TAF15_26573619_Chip-Seq_HEK293_Human1.48041645
42EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46847641
43VDR_24787735_ChIP-Seq_THP-1_Human1.44207119
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.43431667
45TCF7_22412390_ChIP-Seq_EML_Mouse1.40037044
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.40010488
47VDR_21846776_ChIP-Seq_THP-1_Human1.39153418
48KDM2B_26808549_Chip-Seq_DND41_Human1.37079187
49* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36279342
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34408543
51* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.33625589
52TFEB_21752829_ChIP-Seq_HELA_Human1.33431893
53GATA3_26560356_Chip-Seq_TH2_Human1.32004352
54* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.31221561
55GATA1_19941826_ChIP-Seq_K562_Human1.29557317
56NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28737344
57LXR_22292898_ChIP-Seq_THP-1_Human1.25651728
58ZNF263_19887448_ChIP-Seq_K562_Human1.25100199
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23547057
60* PU_27001747_Chip-Seq_BMDM_Mouse1.19361071
61SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15007578
62PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14087769
63TP63_17297297_ChIP-ChIP_HaCaT_Human1.13916557
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13117332
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12893532
66* RUNX1_22412390_ChIP-Seq_EML_Mouse1.12606254
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.11308396
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.09941734
69* SPI1_23547873_ChIP-Seq_NB4_Human1.08513589
70BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04873235
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.04490734
72* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04060382
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02699120
74* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02054129
75* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99005951
76MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97837398
77PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97015966
78HIF1A_21447827_ChIP-Seq_MCF-7_Human0.96902909
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96302948
80GATA2_19941826_ChIP-Seq_K562_Human0.96108585
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.96049386
82NCOR1_26117541_ChIP-Seq_K562_Human0.95110409
83CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94305173
84SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93004438
85CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92587406
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.89055796
87VDR_23849224_ChIP-Seq_CD4+_Human0.87442132
88ELF1_17652178_ChIP-ChIP_JURKAT_Human0.86759663
89BCL6_27268052_Chip-Seq_Bcells_Human0.86392346
90E2F4_17652178_ChIP-ChIP_JURKAT_Human0.85364257
91ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85102817
92ELK1_19687146_ChIP-ChIP_HELA_Human0.85077903
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85010046
94TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.83909773
95HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82020214
96PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81407618
97BCOR_27268052_Chip-Seq_Bcells_Human0.80166955
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.80117758
99ELK3_25401928_ChIP-Seq_HUVEC_Human0.79486827
100MYC_18940864_ChIP-ChIP_HL60_Human0.78669834
101VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.77245068
102GATA1_19941827_ChIP-Seq_MEL86_Mouse0.76455347
103CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.75913372
104CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.75428973
105STAT3_1855785_ChIP-Seq_MESCs_Mouse0.73912484
106GATA2_21666600_ChIP-Seq_HMVEC_Human0.73850907
107TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.73689576
108FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.72252282
109GATA2_22383799_ChIP-Seq_G1ME_Mouse0.70729283
110EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.70534994
111SPI1_23127762_ChIP-Seq_K562_Human0.70156429
112SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.70139665
113* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.69443950
114SMRT_27268052_Chip-Seq_Bcells_Human0.66782526
115RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65967792
116PRDM14_20953172_ChIP-Seq_ESCs_Human0.64937242
117CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.64246275
118* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.63689346
119ELF5_23300383_ChIP-Seq_T47D_Human0.62940799
120NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.62738821
121PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.62030965
122CLOCK_20551151_ChIP-Seq_293T_Human0.61771106
123MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.57458392
124GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.56771157
125* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.56457176
126PU.1_20513432_ChIP-Seq_Bcells_Mouse0.55303152
127LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.54185370
128GATA1_19941827_ChIP-Seq_MEL_Mouse0.52915957
129FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.50059616
130HOXB4_20404135_ChIP-ChIP_EML_Mouse0.49540819
131SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.47573546

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer6.86020174
2MP0001835_abnormal_antigen_presentation5.69472641
3MP0005671_abnormal_response_to5.66039955
4MP0001853_heart_inflammation3.97477482
5MP0004782_abnormal_surfactant_physiolog3.88406677
6MP0003436_decreased_susceptibility_to3.71039633
7MP0000604_amyloidosis3.58645377
8MP0000465_gastrointestinal_hemorrhage3.57326755
9MP0009840_abnormal_foam_cell3.53786643
10MP0003763_abnormal_thymus_physiology3.52057943
11MP0000685_abnormal_immune_system3.34381018
12MP0001958_emphysema3.24288030
13MP0005167_abnormal_blood-brain_barrier3.22734116
14MP0009333_abnormal_splenocyte_physiolog3.20959776
15MP0002405_respiratory_system_inflammati3.15936783
16MP0009785_altered_susceptibility_to2.88087922
17MP0006082_CNS_inflammation2.87740255
18MP0009278_abnormal_bone_marrow2.69462944
19MP0002877_abnormal_melanocyte_morpholog2.67500388
20MP0005000_abnormal_immune_tolerance2.65827131
21MP0002148_abnormal_hypersensitivity_rea2.64579569
22MP0001800_abnormal_humoral_immune2.51252974
23MP0003303_peritoneal_inflammation2.35847414
24MP0000343_altered_response_to2.29704626
25MP0005025_abnormal_response_to2.15903964
26MP0001873_stomach_inflammation2.14810035
27MP0003866_abnormal_defecation2.13372557
28MP0002723_abnormal_immune_serum2.11525753
29MP0005387_immune_system_phenotype2.06849256
30MP0001790_abnormal_immune_system2.06849256
31MP0002398_abnormal_bone_marrow2.00097042
32MP0002420_abnormal_adaptive_immunity1.98323131
33MP0005058_abnormal_lysosome_morphology1.96771491
34MP0001819_abnormal_immune_cell1.95516090
35MP0003172_abnormal_lysosome_physiology1.94837768
36MP0003806_abnormal_nucleotide_metabolis1.93714843
37MP0002166_altered_tumor_susceptibility1.84761369
38MP0005451_abnormal_body_composition1.84559456
39MP0004233_abnormal_muscle_weight1.77609212
40MP0010155_abnormal_intestine_physiology1.74267106
41MP0003045_fibrosis1.72908540
42MP0002452_abnormal_antigen_presenting1.71434716
43MP0004510_myositis1.65885830
44MP0001501_abnormal_sleep_pattern1.63477903
45MP0000716_abnormal_immune_system1.62216933
46MP0000689_abnormal_spleen_morphology1.61138375
47MP0000703_abnormal_thymus_morphology1.56860661
48MP0002722_abnormal_immune_system1.52463930
49MP0001845_abnormal_inflammatory_respons1.52169103
50MP0002006_tumorigenesis1.52149234
51MP0008004_abnormal_stomach_pH1.47020329
52MP0002419_abnormal_innate_immunity1.46130271
53MP0008057_abnormal_DNA_replication1.43258144
54MP0002139_abnormal_hepatobiliary_system1.35109822
55MP0002429_abnormal_blood_cell1.34507515
56MP0002396_abnormal_hematopoietic_system1.32825959
57MP0001533_abnormal_skeleton_physiology1.31763874
58MP0001881_abnormal_mammary_gland1.28054273
59MP0003656_abnormal_erythrocyte_physiolo1.26046340
60MP0000371_diluted_coat_color1.24152440
61MP0002132_abnormal_respiratory_system1.22561283
62MP0003448_altered_tumor_morphology1.20652828
63MP0010307_abnormal_tumor_latency1.19278763
64MP0004947_skin_inflammation1.17192599
65MP0008260_abnormal_autophagy1.16202851
66MP0003724_increased_susceptibility_to1.12743300
67MP0001348_abnormal_lacrimal_gland1.12566825
68MP0010352_gastrointestinal_tract_polyps1.11415782
69MP0001849_ear_inflammation1.08715847
70MP0002837_dystrophic_cardiac_calcinosis1.06084780
71MP0003091_abnormal_cell_migration1.03820693
72MP0002138_abnormal_hepatobiliary_system1.02275779
73MP0004808_abnormal_hematopoietic_stem1.01429111
74MP0003195_calcinosis1.00676416
75MP0000920_abnormal_myelination0.99283693
76MP0009764_decreased_sensitivity_to0.98390062
77MP0002933_joint_inflammation0.95491364
78MP0005164_abnormal_response_to0.91301403
79MP0005165_increased_susceptibility_to0.82646949
80MP0008469_abnormal_protein_level0.82178349
81MP0003828_pulmonary_edema0.81266775
82MP0002254_reproductive_system_inflammat0.78778783
83MP0005464_abnormal_platelet_physiology0.78531697
84MP0000858_altered_metastatic_potential0.78434484
85MP0008874_decreased_physiological_sensi0.78268647
86MP0000569_abnormal_digit_pigmentation0.77584765
87MP0003690_abnormal_glial_cell0.77147987
88MP0002693_abnormal_pancreas_physiology0.76700918
89MP0005166_decreased_susceptibility_to0.76189939
90MP0003183_abnormal_peptide_metabolism0.76182145
91MP0002019_abnormal_tumor_incidence0.72011315
92MP0003646_muscle_fatigue0.70833760
93MP0000609_abnormal_liver_physiology0.68000767
94MP0002168_other_aberrant_phenotype0.65918826
95MP0003191_abnormal_cellular_cholesterol0.65582641
96MP0003329_amyloid_beta_deposits0.65446161
97MP0000627_abnormal_mammary_gland0.64807898
98MP0000490_abnormal_crypts_of0.61511110
99MP0005319_abnormal_enzyme/_coenzyme0.61123171
100MP0002332_abnormal_exercise_endurance0.60488504
101MP0001663_abnormal_digestive_system0.60206517
102MP0009763_increased_sensitivity_to0.60066483
103MP0000249_abnormal_blood_vessel0.57962682
104MP0009765_abnormal_xenobiotic_induced0.56395352
105MP0005390_skeleton_phenotype0.56080883
106MP0002075_abnormal_coat/hair_pigmentati0.55263983
107MP0001186_pigmentation_phenotype0.54547944
108MP0004742_abnormal_vestibular_system0.53140902
109MP0002998_abnormal_bone_remodeling0.53020652
110MP0004883_abnormal_blood_vessel0.52563579
111MP0001216_abnormal_epidermal_layer0.51172156
112MP0005310_abnormal_salivary_gland0.45896675
113MP0005076_abnormal_cell_differentiation0.45505956
114MP0003693_abnormal_embryo_hatching0.45401366
115MP0003453_abnormal_keratinocyte_physiol0.44765546
116MP0001727_abnormal_embryo_implantation0.44155025
117MP0008961_abnormal_basal_metabolism0.43524811
118MP0002136_abnormal_kidney_physiology0.42312418
119MP0003795_abnormal_bone_structure0.34242255
120MP0001851_eye_inflammation0.33388181
121MP0000598_abnormal_liver_morphology0.32418582
122MP0001485_abnormal_pinna_reflex0.32063313
123MP0002133_abnormal_respiratory_system0.30824727
124MP0005388_respiratory_system_phenotype0.30824727
125MP0005397_hematopoietic_system_phenotyp0.29964006
126MP0001545_abnormal_hematopoietic_system0.29964006
127MP0004197_abnormal_fetal_growth/weight/0.29836165
128MP0003075_altered_response_to0.29194616
129MP0008569_lethality_at_weaning0.29123338
130MP0002083_premature_death0.24788250
131MP0005381_digestive/alimentary_phenotyp0.23338169
132MP0005647_abnormal_sex_gland0.22191203
133MP0002089_abnormal_postnatal_growth/wei0.22080667
134MP0001119_abnormal_female_reproductive0.21244359
135MP0004957_abnormal_blastocyst_morpholog0.20441585
136MP0004381_abnormal_hair_follicle0.19843088
137MP0005584_abnormal_enzyme/coenzyme_acti0.19818142
138MP0005023_abnormal_wound_healing0.19676849

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)9.34485714
2T lymphocytopenia (HP:0005403)7.07216973
3Abnormality of T cell number (HP:0011839)7.06684516
4Elevated erythrocyte sedimentation rate (HP:0003565)6.67192200
5Nasal polyposis (HP:0100582)5.69927219
6Gastrointestinal infarctions (HP:0005244)5.63580231
7Increased IgM level (HP:0003496)5.59542956
8Increased density of long bones (HP:0006392)5.35394735
9Recurrent abscess formation (HP:0002722)5.28779169
10Abnormality of T cells (HP:0002843)5.24754386
11IgA deficiency (HP:0002720)5.20710608
12Recurrent bacterial skin infections (HP:0005406)4.83998251
13Abnormality of the nasal mucosa (HP:0000433)4.64597328
14Abnormality of macrophages (HP:0004311)4.61516666
15Persistence of primary teeth (HP:0006335)4.44682335
16IgG deficiency (HP:0004315)4.36553054
17Abnormality of liposaccharide metabolism (HP:0010968)4.36410992
18Abnormality of glycosphingolipid metabolism (HP:0004343)4.36410992
19Abnormality of glycolipid metabolism (HP:0010969)4.36410992
20Vacuolated lymphocytes (HP:0001922)4.30974036
21Thrombocytosis (HP:0001894)4.26187226
22Severe combined immunodeficiency (HP:0004430)4.19545251
23Eczematoid dermatitis (HP:0000976)4.18706150
24Recurrent viral infections (HP:0004429)4.15625433
25Recurrent bronchitis (HP:0002837)4.14334032
26Arterial thrombosis (HP:0004420)4.09788779
27Joint swelling (HP:0001386)4.04460357
28Recurrent gram-negative bacterial infections (HP:0005420)3.98051670
29Recurrent fungal infections (HP:0002841)3.91660921
30Chronic otitis media (HP:0000389)3.77047251
31Amaurosis fugax (HP:0100576)3.75248334
32Abnormality of T cell physiology (HP:0011840)3.70296460
33Combined immunodeficiency (HP:0005387)3.62683126
34Chronic diarrhea (HP:0002028)3.42244914
35Myositis (HP:0100614)3.34112899
36Optic neuritis (HP:0100653)3.32095849
37Retrobulbar optic neuritis (HP:0100654)3.32095849
38Abnormality of B cell number (HP:0010975)3.27315973
39B lymphocytopenia (HP:0010976)3.27315973
40Mediastinal lymphadenopathy (HP:0100721)3.27078049
41Chest pain (HP:0100749)3.23379167
42Vasculitis (HP:0002633)3.21723007
43Thin bony cortex (HP:0002753)3.13082594
44Petechiae (HP:0000967)3.05474215
45Pulmonary infiltrates (HP:0002113)3.04051230
46Autoimmune thrombocytopenia (HP:0001973)3.02857602
47Hematochezia (HP:0002573)3.02411617
48Metaphyseal irregularity (HP:0003025)3.00773160
49Recurrent skin infections (HP:0001581)3.00518275
50Increased cerebral lipofuscin (HP:0011813)2.93237674
51Hypergammaglobulinemia (HP:0010702)2.91988490
52Loss of speech (HP:0002371)2.91793310
53Fatigue (HP:0012378)2.89434076
54Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.86149520
55Dysostosis multiplex (HP:0000943)2.85969377
56Panhypogammaglobulinemia (HP:0003139)2.84830115
57Leukocytosis (HP:0001974)2.79891318
58Increased neuronal autofluorescent lipopigment (HP:0002074)2.77439035
59Orchitis (HP:0100796)2.77307361
60Anomalous pulmonary venous return (HP:0010772)2.68172135
61Gingival bleeding (HP:0000225)2.66233057
62Peritonitis (HP:0002586)2.63059557
63Myocardial infarction (HP:0001658)2.60500673
64Eosinophilia (HP:0001880)2.56298176
65Abnormality of cells of the lymphoid lineage (HP:0012140)2.56080242
66Slow saccadic eye movements (HP:0000514)2.55283047
67Esophageal varix (HP:0002040)2.54225956
68Lymphoma (HP:0002665)2.52381627
69Abnormality of eosinophils (HP:0001879)2.51211408
70IgM deficiency (HP:0002850)2.50972812
71Lymphopenia (HP:0001888)2.48718803
72Aplastic anemia (HP:0001915)2.48025057
73Thrombophlebitis (HP:0004418)2.46564028
74Abnormal delayed hypersensitivity skin test (HP:0002963)2.44807588
75Abnormality of binocular vision (HP:0011514)2.43958208
76Diplopia (HP:0000651)2.43958208
77Acute myeloid leukemia (HP:0004808)2.43584721
78Abnormality of the peritoneum (HP:0002585)2.42618426
79Cerebral hemorrhage (HP:0001342)2.37750611
80Enlarged epiphyses (HP:0010580)2.33984523
81Abnormality of the pulmonary veins (HP:0011718)2.33976306
82Cellulitis (HP:0100658)2.33131093
83Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.30908286
84Abnormality of oral frenula (HP:0000190)2.30339509
85Gangrene (HP:0100758)2.30121366
86Polycythemia (HP:0001901)2.30036455
87Urticaria (HP:0001025)2.28570153
88Hemoptysis (HP:0002105)2.28564059
89Autoimmune hemolytic anemia (HP:0001890)2.28375256
90Pulmonary embolism (HP:0002204)2.28182019
91Spontaneous abortion (HP:0005268)2.27383226
92Aplasia cutis congenita (HP:0001057)2.25210361
93Abnormal trabecular bone morphology (HP:0100671)2.24120055
94Hepatosplenomegaly (HP:0001433)2.23553756
95Upper motor neuron abnormality (HP:0002127)2.21845552
96Flat occiput (HP:0005469)2.18305754
97Gastrointestinal stroma tumor (HP:0100723)2.17498245
98Bronchitis (HP:0012387)2.16476934
99Abnormality of the prostate (HP:0008775)2.16175272
100Amyloidosis (HP:0011034)2.16055573
101Keratoconjunctivitis sicca (HP:0001097)2.15883022
102Porencephaly (HP:0002132)2.13830001
103Oral leukoplakia (HP:0002745)2.11441169
104Arthralgia (HP:0002829)2.09773060
105Granulocytopenia (HP:0001913)2.09384449
106Absent frontal sinuses (HP:0002688)2.09221603
107Neurofibrillary tangles (HP:0002185)2.08312066
108Gingivitis (HP:0000230)2.04932477
109Symptomatic seizures (HP:0011145)2.04832241
110Chronic mucocutaneous candidiasis (HP:0002728)2.03730722
111Recurrent cutaneous fungal infections (HP:0011370)2.03730722
112Septate vagina (HP:0001153)2.03114914
113Somatic mutation (HP:0001428)2.00729272
114Delayed epiphyseal ossification (HP:0002663)1.99883219
115Spastic diplegia (HP:0001264)1.99360105
116Acute hepatic failure (HP:0006554)1.98076136
117Abnormality of the costochondral junction (HP:0000919)1.97497176
118Anorexia (HP:0002039)1.96940601
119Abnormal number of incisors (HP:0011064)1.96931642
120Bone pain (HP:0002653)1.95449382
121Rough bone trabeculation (HP:0100670)1.94563858
122Abnormality of pyrimidine metabolism (HP:0004353)1.93840015
123Keratoconjunctivitis (HP:0001096)1.92910078
124Increased serum ferritin (HP:0003281)1.92369133
125Disinhibition (HP:0000734)1.91378980
126Submucous cleft hard palate (HP:0000176)1.91267178
127Cerebral ischemia (HP:0002637)1.90913596
128Abnormality of the vasculature of the conjunctiva (HP:0008054)1.90891745
129Thoracic kyphosis (HP:0002942)1.90816362
130Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.90504349
131Malnutrition (HP:0004395)1.89002832
132Hypophosphatemia (HP:0002148)1.88738877
133Protuberant abdomen (HP:0001538)1.88684410
134Diminished motivation (HP:0000745)1.87826492
135Spondylolisthesis (HP:0003302)1.86032995
136Neuronal loss in central nervous system (HP:0002529)1.85838150
137Chronic sinusitis (HP:0011109)1.85236185
138Cerebral inclusion bodies (HP:0100314)1.84401455
139Femoral bowing (HP:0002980)1.84242645
140Pathologic fracture (HP:0002756)1.83889763
141Hepatitis (HP:0012115)1.82808875
142Acrocyanosis (HP:0001063)1.82485700
143Restrictive lung disease (HP:0002091)1.81270765
144Chronic obstructive pulmonary disease (HP:0006510)1.81265111
145Obstructive lung disease (HP:0006536)1.81265111
146Meningitis (HP:0001287)1.80908026
147Increased CSF protein (HP:0002922)1.80673305
148Colitis (HP:0002583)1.80603703
149Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.80241098
150Portal hypertension (HP:0001409)1.77457992
151Emphysema (HP:0002097)1.77189436
152Abnormal platelet function (HP:0011869)1.77183728
153Impaired platelet aggregation (HP:0003540)1.77183728
154Encephalitis (HP:0002383)1.77008075
155Premature loss of primary teeth (HP:0006323)1.74250402
156Thoracolumbar scoliosis (HP:0002944)1.73049535
157Exertional dyspnea (HP:0002875)1.72927897
158Peripheral hypomyelination (HP:0007182)1.72683785
159Pustule (HP:0200039)1.72291435
160Cutis marmorata (HP:0000965)1.71534404
161Periodontitis (HP:0000704)1.71065762
162Increased IgE level (HP:0003212)1.69741971
163Nausea (HP:0002018)1.69555697

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK39.24207361
2TXK7.36073359
3MAP4K16.36520299
4JAK33.95654888
5ITK3.81874235
6ZAP703.61560420
7MAP3K143.40460567
8PRPF4B2.89992155
9PIM22.89662902
10RIPK42.74661847
11MATK2.51283347
12TTN2.44104088
13CSK2.20280645
14TEC2.15187880
15CAMK1D2.00306980
16IKBKB1.98300906
17MAP3K111.93009796
18CAMKK21.91693201
19CHUK1.87489810
20DDR21.85758041
21FGFR41.82909670
22TAOK11.74975926
23TYK21.69760376
24TBK11.61449241
25LCK1.59226946
26IKBKE1.57138833
27NME11.53395098
28TAOK21.50858439
29CAMK1G1.47728363
30NME21.41677673
31SYK1.32123835
32BTK1.30876768
33HCK1.29361815
34JAK11.28590249
35MAP3K71.23013642
36RAF11.20016544
37CDC42BPA1.19640787
38PIM11.16841980
39EPHA31.15322967
40STK101.11396396
41FGFR31.07506076
42FES1.06047967
43TESK21.05060622
44ALK1.03773647
45JAK21.02562043
46MAP2K31.00026135
47ICK0.99778557
48MAP3K130.98323356
49FGFR10.94598274
50TSSK60.94355249
51BMPR20.87608029
52MAP3K30.86348256
53PRKCQ0.83491801
54EEF2K0.82693878
55EPHB10.82348527
56STK240.82022173
57MST40.81502706
58PAK20.79316788
59TRIB30.79087168
60LYN0.78886612
61IRAK40.77918269
62RPS6KA40.75511532
63MST1R0.74809481
64MAP3K80.74738665
65LRRK20.74324126
66PRKCH0.73448789
67NTRK20.70673926
68MOS0.69673942
69EIF2AK10.68270718
70RPS6KA20.67417281
71TLK10.66639111
72RPS6KA50.65214783
73GRK70.64195979
74RPS6KC10.63139225
75RPS6KL10.63139225
76LIMK10.62636315
77KSR20.61798391
78GSK3A0.59819842
79IRAK10.56492623
80TYRO30.55336889
81MAPK110.52689280
82STK390.52149438
83RPS6KA60.52071242
84ROCK20.52047530
85MAP3K60.50309929
86TAOK30.50146873
87MARK30.48454457
88INSR0.48357016
89EGFR0.47936763
90SIK20.47932278
91CAMKK10.45136123
92CDK120.44990952
93BMX0.43063266
94WNK10.42911698
95SRPK10.42105245
96MAPK40.41640619
97PDPK10.40768970
98MAP3K10.39825704
99NEK90.39718153
100KIT0.38809898
101MAP3K50.38765108
102ABL20.38347975
103KDR0.37162603
104IGF1R0.37111460
105WNK40.36187905
106ARAF0.35547052
107FLT30.35545706
108PKN10.34933089
109PKN20.34290661
110PAK40.34018113
111TRPM70.32793978
112RPS6KA10.32626267
113PDK10.30425911
114CDK40.29564401
115ERN10.27522706
116RPS6KB20.26890138
117SCYL20.26792665
118CDK60.24741073
119PASK0.24252728
120MKNK10.24024839
121MAP3K100.23581998
122PDGFRB0.23577685
123CHEK10.22290427
124PDGFRA0.21530667
125CDK90.20906591
126ABL10.20772267
127BLK0.19622346
128BRD40.19256009
129FYN0.19033810
130NLK0.18802024
131MAPKAPK20.18283479
132GRK60.16817748
133MELK0.16458196
134FGR0.15327968
135CLK10.15200986
136KSR10.14930583
137CSNK2A20.14100419
138MAPK30.13287324
139PRKCB0.12932462
140ERBB40.12473377
141TGFBR20.12173529
142AURKB0.10707386
143PRKACG0.10583413

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053306.97786329
2Graft-versus-host disease_Homo sapiens_hsa053326.21245917
3Asthma_Homo sapiens_hsa053105.54670885
4Type I diabetes mellitus_Homo sapiens_hsa049405.44897616
5Autoimmune thyroid disease_Homo sapiens_hsa053203.98753059
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.93626368
7T cell receptor signaling pathway_Homo sapiens_hsa046602.92741460
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.51095919
9Other glycan degradation_Homo sapiens_hsa005112.44112044
10Hematopoietic cell lineage_Homo sapiens_hsa046402.32941596
11Fc epsilon RI signaling pathway_Homo sapiens_hsa046642.13615357
12NF-kappa B signaling pathway_Homo sapiens_hsa040642.05898317
13Jak-STAT signaling pathway_Homo sapiens_hsa046301.98868467
14* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.87552659
15Primary immunodeficiency_Homo sapiens_hsa053401.86612493
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.81418532
17Bladder cancer_Homo sapiens_hsa052191.73162704
18Measles_Homo sapiens_hsa051621.67776999
19Sulfur metabolism_Homo sapiens_hsa009201.56853087
20Lysosome_Homo sapiens_hsa041421.53327541
21Leishmaniasis_Homo sapiens_hsa051401.50587567
22Antigen processing and presentation_Homo sapiens_hsa046121.50057308
23Rheumatoid arthritis_Homo sapiens_hsa053231.40469179
24TNF signaling pathway_Homo sapiens_hsa046681.36958532
25Phagosome_Homo sapiens_hsa041451.34409632
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26378629
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.25808329
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.24183068
29Salmonella infection_Homo sapiens_hsa051321.13731968
30African trypanosomiasis_Homo sapiens_hsa051431.10338016
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09248519
32Vibrio cholerae infection_Homo sapiens_hsa051101.04512377
33Malaria_Homo sapiens_hsa051440.99563034
34Toxoplasmosis_Homo sapiens_hsa051450.98046836
35Viral myocarditis_Homo sapiens_hsa054160.96820615
36Herpes simplex infection_Homo sapiens_hsa051680.92708828
37Osteoclast differentiation_Homo sapiens_hsa043800.92296310
38NOD-like receptor signaling pathway_Homo sapiens_hsa046210.88474475
39Amoebiasis_Homo sapiens_hsa051460.88327005
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87718842
41Apoptosis_Homo sapiens_hsa042100.86348258
42Glycosaminoglycan degradation_Homo sapiens_hsa005310.85732497
43HTLV-I infection_Homo sapiens_hsa051660.85083920
44Systemic lupus erythematosus_Homo sapiens_hsa053220.84568746
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84005487
46Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80794058
47Legionellosis_Homo sapiens_hsa051340.79129642
48Collecting duct acid secretion_Homo sapiens_hsa049660.74548570
49Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71904419
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.70974035
51GnRH signaling pathway_Homo sapiens_hsa049120.69113511
52Pertussis_Homo sapiens_hsa051330.68919449
53Estrogen signaling pathway_Homo sapiens_hsa049150.63909005
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62889940
55* Chemokine signaling pathway_Homo sapiens_hsa040620.61419506
56Prolactin signaling pathway_Homo sapiens_hsa049170.56541621
57Hepatitis B_Homo sapiens_hsa051610.56012028
58Influenza A_Homo sapiens_hsa051640.54622513
59Acute myeloid leukemia_Homo sapiens_hsa052210.53856820
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52011405
61Dorso-ventral axis formation_Homo sapiens_hsa043200.50872291
62Viral carcinogenesis_Homo sapiens_hsa052030.49399825
63Tuberculosis_Homo sapiens_hsa051520.49197451
64B cell receptor signaling pathway_Homo sapiens_hsa046620.48462732
65Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47616034
66Non-small cell lung cancer_Homo sapiens_hsa052230.46055396
67Chronic myeloid leukemia_Homo sapiens_hsa052200.45743250
68Renal cell carcinoma_Homo sapiens_hsa052110.45309687
69Shigellosis_Homo sapiens_hsa051310.43833507
70Epstein-Barr virus infection_Homo sapiens_hsa051690.43634258
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43154773
72PPAR signaling pathway_Homo sapiens_hsa033200.41856195
73Mineral absorption_Homo sapiens_hsa049780.40668968
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.39508845
75Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.39044949
76Notch signaling pathway_Homo sapiens_hsa043300.35768952
77Proteasome_Homo sapiens_hsa030500.31606542
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29017208
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.28434315
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25437123
81Pentose phosphate pathway_Homo sapiens_hsa000300.24539287
82Hepatitis C_Homo sapiens_hsa051600.23894221
83Ribosome_Homo sapiens_hsa030100.23829492
84Small cell lung cancer_Homo sapiens_hsa052220.23739325
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.23398298
86One carbon pool by folate_Homo sapiens_hsa006700.23078522
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22878809
88Pancreatic cancer_Homo sapiens_hsa052120.21758871
89Staphylococcus aureus infection_Homo sapiens_hsa051500.20079922
90MAPK signaling pathway_Homo sapiens_hsa040100.19928357
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16627002
92Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.13995513
93RNA transport_Homo sapiens_hsa030130.11319829
94PI3K-Akt signaling pathway_Homo sapiens_hsa041510.10808699
95HIF-1 signaling pathway_Homo sapiens_hsa040660.10754684
96VEGF signaling pathway_Homo sapiens_hsa043700.09912809
97Spliceosome_Homo sapiens_hsa030400.09331324
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.08619791
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.08195972
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.06767192
101mTOR signaling pathway_Homo sapiens_hsa041500.05393970
102MicroRNAs in cancer_Homo sapiens_hsa052060.04536373
103Platelet activation_Homo sapiens_hsa046110.03715644
104Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.01935800
105TGF-beta signaling pathway_Homo sapiens_hsa043500.01748183
106Colorectal cancer_Homo sapiens_hsa052100.01618077
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964-0.1240969
108mRNA surveillance pathway_Homo sapiens_hsa03015-0.1203294
109Fatty acid biosynthesis_Homo sapiens_hsa00061-0.1145725
110ErbB signaling pathway_Homo sapiens_hsa04012-0.1050599
111Cysteine and methionine metabolism_Homo sapiens_hsa00270-0.1027563
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250-0.0987403
113Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750-0.0760279
114RNA degradation_Homo sapiens_hsa03018-0.0755929
115RNA polymerase_Homo sapiens_hsa03020-0.0727405
116Cocaine addiction_Homo sapiens_hsa05030-0.0700193
117Proteoglycans in cancer_Homo sapiens_hsa05205-0.0689845
118Thyroid cancer_Homo sapiens_hsa05216-0.0675829
119p53 signaling pathway_Homo sapiens_hsa04115-0.0511434
120Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0490135
121Prion diseases_Homo sapiens_hsa05020-0.0453493
122Alcoholism_Homo sapiens_hsa05034-0.0201857
123Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120-0.0097314
124Sphingolipid signaling pathway_Homo sapiens_hsa04071-0.0089574
125Insulin resistance_Homo sapiens_hsa04931-0.0027472
126Type II diabetes mellitus_Homo sapiens_hsa04930-0.0008089

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