CCDC89

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell wall macromolecule catabolic process (GO:0016998)9.99928557
2cell wall macromolecule metabolic process (GO:0044036)9.99928557
3cilium movement (GO:0003341)9.88313378
4binding of sperm to zona pellucida (GO:0007339)9.86306013
5cell-cell recognition (GO:0009988)9.80128921
6plasma membrane fusion (GO:0045026)9.77139987
7motile cilium assembly (GO:0044458)8.98969255
8spermatid development (GO:0007286)8.96107063
9regulation of cilium movement (GO:0003352)8.95393658
10reproduction (GO:0000003)8.88768700
11piRNA metabolic process (GO:0034587)8.59730081
12male meiosis (GO:0007140)8.48933591
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.39438334
14synaptonemal complex organization (GO:0070193)7.66403675
15single fertilization (GO:0007338)7.41863700
16sperm capacitation (GO:0048240)7.40695825
17synaptonemal complex assembly (GO:0007130)7.23500326
18ventricular system development (GO:0021591)6.53520835
19fertilization (GO:0009566)6.24299162
20primary alcohol catabolic process (GO:0034310)6.17687501
21negative regulation of inclusion body assembly (GO:0090084)5.91465866
22spermatogenesis (GO:0007283)5.85104035
23male gamete generation (GO:0048232)5.82931099
24DNA methylation involved in gamete generation (GO:0043046)5.68619206
25male meiosis I (GO:0007141)5.68326612
26microtubule severing (GO:0051013)5.51896143
27ethanol metabolic process (GO:0006067)5.40403289
28regulation of microtubule-based movement (GO:0060632)5.37200534
29gamete generation (GO:0007276)5.36516395
30cellular process involved in reproduction in multicellular organism (GO:0022412)5.19774085
31organic cation transport (GO:0015695)5.13395204
32chromosome organization involved in meiosis (GO:0070192)5.11673109
33vitamin transmembrane transport (GO:0035461)5.10118618
34germ cell development (GO:0007281)5.09909270
35microtubule depolymerization (GO:0007019)5.08152079
36diterpenoid biosynthetic process (GO:0016102)5.04399622
37axoneme assembly (GO:0035082)4.91125013
38cell recognition (GO:0008037)4.89270309
39regulation of inclusion body assembly (GO:0090083)4.88517180
40regulation of germinal center formation (GO:0002634)4.78407769
41calcium ion-dependent exocytosis (GO:0017156)4.72819472
42meiotic nuclear division (GO:0007126)4.71083682
43meiosis I (GO:0007127)4.52786490
44protein localization to cilium (GO:0061512)4.47785201
45protein polyglutamylation (GO:0018095)4.47154341
46intraciliary transport (GO:0042073)4.41583177
47response to xenobiotic stimulus (GO:0009410)4.38489609
48establishment of apical/basal cell polarity (GO:0035089)4.35147051
49glomerular epithelial cell development (GO:0072310)4.29466924
50spermatid nucleus differentiation (GO:0007289)4.26882877
51multicellular organismal reproductive process (GO:0048609)4.21023212
52negative regulation of humoral immune response (GO:0002921)4.20533165
53nucleoside diphosphate phosphorylation (GO:0006165)4.18800586
54regulation of interleukin-5 production (GO:0032674)4.15175067
55left/right pattern formation (GO:0060972)4.13878792
56seminiferous tubule development (GO:0072520)4.12053010
57pyrimidine-containing compound transmembrane transport (GO:0072531)4.10706035
58regulation of interleukin-13 production (GO:0032656)3.93041574
59lung epithelium development (GO:0060428)3.92609014
60ethanol oxidation (GO:0006069)3.91490583
61meiotic cell cycle (GO:0051321)3.85848525
62genitalia morphogenesis (GO:0035112)3.82708209
63one-carbon compound transport (GO:0019755)3.81973835
64terpenoid biosynthetic process (GO:0016114)3.81839967
65tolerance induction (GO:0002507)3.81820493
66monoubiquitinated protein deubiquitination (GO:0035520)3.79502611
67cilium organization (GO:0044782)3.78844468
68GTP biosynthetic process (GO:0006183)3.76521873
69chaperone-mediated protein complex assembly (GO:0051131)3.74053018
70negative regulation of immunoglobulin mediated immune response (GO:0002890)3.72107890
71negative regulation of B cell mediated immunity (GO:0002713)3.72107890
72cell projection assembly (GO:0030031)3.66796788
73negative regulation of T cell differentiation in thymus (GO:0033085)3.65416735
74cilium morphogenesis (GO:0060271)3.63041566
75microtubule-based movement (GO:0007018)3.58943915
76glycerol ether metabolic process (GO:0006662)3.58186202
77cilium assembly (GO:0042384)3.57320002
78establishment of monopolar cell polarity (GO:0061162)3.57038180
79establishment or maintenance of monopolar cell polarity (GO:0061339)3.57038180
80cytoplasmic microtubule organization (GO:0031122)3.53873411
81retinoic acid metabolic process (GO:0042573)3.50172923
82cellular component assembly involved in morphogenesis (GO:0010927)3.49608739
83oligosaccharide catabolic process (GO:0009313)3.46341976
84establishment of planar polarity (GO:0001736)3.44675568
85establishment of tissue polarity (GO:0007164)3.44675568
86negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.43121143
87retinol metabolic process (GO:0042572)3.42659393
88multicellular organismal development (GO:0007275)3.40432680
89negative regulation of organelle assembly (GO:1902116)3.38124827
90ether metabolic process (GO:0018904)3.32281724
91UTP biosynthetic process (GO:0006228)3.31825769
92phosphatidylcholine biosynthetic process (GO:0006656)3.28284969
93synapsis (GO:0007129)3.28218427
94positive regulation of smoothened signaling pathway (GO:0045880)3.21046637
95regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)3.20840817
96positive regulation of tolerance induction (GO:0002645)3.16788351
97hyperosmotic salinity response (GO:0042538)3.16186092
98amino-acid betaine transport (GO:0015838)3.13157943
99carnitine transport (GO:0015879)3.13157943
100carnitine transmembrane transport (GO:1902603)3.11435487
101negative regulation of T-helper cell differentiation (GO:0045623)3.04703497
102negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.04703497
103lactate metabolic process (GO:0006089)3.04275192
104primary alcohol metabolic process (GO:0034308)3.04070637
105left/right axis specification (GO:0070986)3.01751514
106ether lipid metabolic process (GO:0046485)3.01184315
107chromosome condensation (GO:0030261)3.00867275
108UTP metabolic process (GO:0046051)2.99266514
109gene silencing by RNA (GO:0031047)2.98312286
110regulation of metalloenzyme activity (GO:0048552)2.95363498
111DNA packaging (GO:0006323)2.92201073
112positive regulation of catecholamine secretion (GO:0033605)2.90846297
113carnitine metabolic process (GO:0009437)2.90619815
114negative regulation of alpha-beta T cell differentiation (GO:0046639)2.89443182
115regulation of spindle checkpoint (GO:0090231)2.89390450
116meiotic cell cycle process (GO:1903046)2.89219534
117regulation of centriole replication (GO:0046599)2.88079776
118metanephric mesenchyme development (GO:0072075)2.87765767
119positive regulation of macrophage activation (GO:0043032)2.87733386
120histone H3-K9 demethylation (GO:0033169)2.86276432
121glomerular basement membrane development (GO:0032836)2.86047138
122glucosamine-containing compound catabolic process (GO:1901072)2.84075581
123protein refolding (GO:0042026)2.83853807
124regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.83713868
125phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.82974438
126polyol catabolic process (GO:0046174)2.78689429
127response to dietary excess (GO:0002021)2.76841418
128lateral ventricle development (GO:0021670)2.76576907
129microtubule polymerization or depolymerization (GO:0031109)2.75834946
130alditol metabolic process (GO:0019400)2.75445769
131peptidyl-glutamic acid modification (GO:0018200)2.74249817
132positive regulation of uterine smooth muscle contraction (GO:0070474)2.73502090
133kidney mesenchyme development (GO:0072074)2.72346496
134protein import into peroxisome matrix (GO:0016558)2.72291232
135glycolytic process (GO:0006096)2.71264858
136O-glycan processing (GO:0016266)2.70631396
137microtubule bundle formation (GO:0001578)2.68422636
138exogenous drug catabolic process (GO:0042738)2.65438410
139glutathione derivative metabolic process (GO:1901685)2.63810798
140glutathione derivative biosynthetic process (GO:1901687)2.63810798
141protein K11-linked deubiquitination (GO:0035871)2.62381307
142determination of left/right symmetry (GO:0007368)2.60845041
143aldehyde catabolic process (GO:0046185)2.60427573
144smoothened signaling pathway (GO:0007224)2.60194285
145calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.57127789
146negative regulation of skeletal muscle tissue development (GO:0048642)2.57045489
147guanosine-containing compound biosynthetic process (GO:1901070)2.55686567
148determination of bilateral symmetry (GO:0009855)2.54995750
149centriole assembly (GO:0098534)2.54547304
150maternal behavior (GO:0042711)2.53974852
151regulation of meiosis I (GO:0060631)2.51851376
152specification of symmetry (GO:0009799)2.50347234
153centriole replication (GO:0007099)2.48935392
154nodal signaling pathway (GO:0038092)2.48889035
155CTP metabolic process (GO:0046036)2.48029973
156CTP biosynthetic process (GO:0006241)2.48029973
157microtubule-based process (GO:0007017)2.47668611
158regulation of microtubule depolymerization (GO:0031114)2.44834989
159retinal rod cell development (GO:0046548)2.43535888
160nucleus organization (GO:0006997)2.43154803
161iron ion import (GO:0097286)2.37983820
162regulation of secondary heart field cardioblast proliferation (GO:0003266)2.37589697
163regulation of cardioblast proliferation (GO:0003264)2.37589697
164regulation of uterine smooth muscle contraction (GO:0070472)2.37342272
165cilium or flagellum-dependent cell motility (GO:0001539)13.7990831
166fusion of sperm to egg plasma membrane (GO:0007342)12.8283334
167acrosome assembly (GO:0001675)12.0968228
168sperm motility (GO:0030317)11.9862929
169axonemal dynein complex assembly (GO:0070286)11.0931814
170sperm-egg recognition (GO:0035036)10.9874875
171multicellular organism reproduction (GO:0032504)10.9642230
172epithelial cilium movement (GO:0003351)10.3886216
173acrosome reaction (GO:0007340)10.2568641

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.20042230
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.03226772
3EZH2_22144423_ChIP-Seq_EOC_Human4.90578142
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.75095058
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.54011092
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.19627035
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.10434994
8FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.01228245
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.99127505
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.81044821
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.53956490
12DROSHA_22980978_ChIP-Seq_HELA_Human2.40848555
13PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.35023386
14FLI1_27457419_Chip-Seq_LIVER_Mouse2.25186886
15VDR_22108803_ChIP-Seq_LS180_Human2.23496575
16PIAS1_25552417_ChIP-Seq_VCAP_Human2.20631123
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.18259732
18ZNF217_24962896_ChIP-Seq_MCF-7_Human2.16863730
19AHR_22903824_ChIP-Seq_MCF-7_Human2.12191772
20ZNF274_21170338_ChIP-Seq_K562_Hela2.10082266
21PCGF2_27294783_Chip-Seq_ESCs_Mouse2.07756110
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06094830
23ESR1_21235772_ChIP-Seq_MCF-7_Human2.03057884
24EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.02688898
25FOXM1_26456572_ChIP-Seq_MCF-7_Human1.94599818
26ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.90449499
27GATA1_26923725_Chip-Seq_HPCs_Mouse1.88660049
28KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.84755022
29* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.80112949
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.80055124
31NR3C1_21868756_ChIP-Seq_MCF10A_Human1.79328551
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.78636681
33TP63_23658742_ChIP-Seq_EP156T_Human1.78299457
34TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.77500710
35RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.76734080
36ARNT_22903824_ChIP-Seq_MCF-7_Human1.74790115
37ELK4_26923725_Chip-Seq_MESODERM_Mouse1.72462706
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.70751121
39TP53_18474530_ChIP-ChIP_U2OS_Human1.70167233
40STAT6_21828071_ChIP-Seq_BEAS2B_Human1.65181167
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.62082757
42RNF2_27304074_Chip-Seq_NSC_Mouse1.60080024
43SMAD4_21799915_ChIP-Seq_A2780_Human1.60049980
44FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.59678393
45NFE2_27457419_Chip-Seq_LIVER_Mouse1.56796537
46TAL1_26923725_Chip-Seq_HPCs_Mouse1.54037061
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.52603023
48AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.51045765
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.49999201
50CTNNB1_20460455_ChIP-Seq_HCT116_Human1.48898605
51GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.48241350
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.46801852
53SOX9_24532713_ChIP-Seq_HFSC_Mouse1.46420470
54IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.46143310
55CBP_20019798_ChIP-Seq_JUKART_Human1.46143310
56ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.45540996
57* STAT1_17558387_ChIP-Seq_HELA_Human1.45304967
58TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.43130477
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42935743
60KDM2B_26808549_Chip-Seq_REH_Human1.42717654
61KAP1_22055183_ChIP-Seq_ESCs_Mouse1.40191689
62MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.39287922
63SOX2_20726797_ChIP-Seq_SW620_Human1.38059785
64FLI1_21867929_ChIP-Seq_TH2_Mouse1.37543969
65WDR5_24793694_ChIP-Seq_LNCAP_Human1.37530900
66FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35498480
67FOXA1_25552417_ChIP-Seq_VCAP_Human1.33117382
68CDX2_19796622_ChIP-Seq_MESCs_Mouse1.31340291
69TAF15_26573619_Chip-Seq_HEK293_Human1.30827321
70POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30015866
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30015866
72NANOG_18555785_Chip-Seq_ESCs_Mouse1.29887109
73P63_26484246_Chip-Seq_KERATINOCYTES_Human1.29367783
74KLF5_25053715_ChIP-Seq_YYC3_Human1.28727249
75NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.28328823
76* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.27919728
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26916940
78CDX2_20551321_ChIP-Seq_CACO-2_Human1.26856867
79REST_21632747_ChIP-Seq_MESCs_Mouse1.26454669
80PPAR_26484153_Chip-Seq_NCI-H1993_Human1.26285882
81SOX2_22085726_ChIP-Seq_NPCs_Mouse1.26213040
82PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.25990301
83ZFP57_27257070_Chip-Seq_ESCs_Mouse1.25682258
84CRX_20693478_ChIP-Seq_RETINA_Mouse1.25629210
85STAT1_20625510_ChIP-Seq_HELA_Human1.25270206
86OCT4_18555785_Chip-Seq_ESCs_Mouse1.25151834
87GF1_26923725_Chip-Seq_HPCs_Mouse1.22927454
88TP63_22573176_ChIP-Seq_HFKS_Human1.22325396
89TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22114225
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.22001539
91TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21813307
92GATA3_21867929_ChIP-Seq_CD8_Mouse1.21750104
93PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.21568940
94FOXA2_19822575_ChIP-Seq_HepG2_Human1.21561552
95PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.21534826
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21389020
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20223543
98* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19646184
99P300_18555785_Chip-Seq_ESCs_Mouse1.18770973
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.17402378
101SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.16854266
102CJUN_26792858_Chip-Seq_BT549_Human1.16687168
103LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.16352756
104P53_22387025_ChIP-Seq_ESCs_Mouse1.15113533
105RBPJ_22232070_ChIP-Seq_NCS_Mouse1.15035957
106ETV1_20927104_ChIP-Seq_GIST48_Human1.13865538
107CMYC_18555785_Chip-Seq_ESCs_Mouse1.13647435
108PHF8_20622853_ChIP-Seq_HELA_Human1.13066195
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.12523950
110CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.11738909
111EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.11637993
112HNFA_21074721_ChIP-Seq_CACO-2_Human1.10945296
113KLF4_18555785_Chip-Seq_ESCs_Mouse1.10661515
114SMAD3_21741376_ChIP-Seq_EPCs_Human1.10457997
115ER_23166858_ChIP-Seq_MCF-7_Human1.10316885
116SUZ12_18555785_Chip-Seq_ESCs_Mouse1.10079009
117TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09338618
118STAT3_18555785_Chip-Seq_ESCs_Mouse1.09253536
119P53_21459846_ChIP-Seq_SAOS-2_Human1.08973005
120SMAD3_21741376_ChIP-Seq_HESCs_Human1.08768358
121ESRRB_18555785_Chip-Seq_ESCs_Mouse1.08661721
122CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08508102
123OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08189480
124STAT3_23295773_ChIP-Seq_U87_Human1.07346069
125GATA3_21867929_ChIP-Seq_TH1_Mouse1.07340818
126EP300_21415370_ChIP-Seq_HL-1_Mouse1.05359998
127RUNX1_26923725_Chip-Seq_HPCs_Mouse1.04606373
128GATA3_24758297_ChIP-Seq_MCF-7_Human1.04280191
129GATA4_25053715_ChIP-Seq_YYC3_Human1.03742704
130PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.02257508
131GF1B_26923725_Chip-Seq_HPCs_Mouse1.02123809
132CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.02061607
133EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01423662
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01108484
135* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01026547
136PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.00978317
137ERG_20517297_ChIP-Seq_VCAP_Human1.00834363
138FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.00563655
139RAD21_21589869_ChIP-Seq_MESCs_Mouse1.00020801
140NFYA_21822215_ChIP-Seq_K562_Human0.99996855
141RUNX1_27457419_Chip-Seq_LIVER_Mouse0.99321344
142MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.99282087
143E2F1_18555785_Chip-Seq_ESCs_Mouse0.98358570
144SOX2_18555785_Chip-Seq_ESCs_Mouse0.97856113
145CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96675940
146NFYB_21822215_ChIP-Seq_K562_Human0.96216436
147TP53_16413492_ChIP-PET_HCT116_Human0.95065461
148SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94864638
149SOX9_26525672_Chip-Seq_HEART_Mouse0.94790952
150CTCF_18555785_Chip-Seq_ESCs_Mouse0.94677313
151PU1_27457419_Chip-Seq_LIVER_Mouse0.94630209
152EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.94489431
153TBL1_22424771_ChIP-Seq_293T_Human0.94199022
154SMAD4_21741376_ChIP-Seq_HESCs_Human0.93886140
155SMAD4_21741376_ChIP-Seq_EPCs_Human0.93609475
156CDX2_22108803_ChIP-Seq_LS180_Human0.93345743
157* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92915636
158ZFX_18555785_Chip-Seq_ESCs_Mouse0.92778973
159KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.92644378
160CBP_21632823_ChIP-Seq_H3396_Human0.92591122
161SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.92324313
162FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91652335
163RBPJ_21746931_ChIP-Seq_IB4_Human0.91541194
164SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.91468758
165SPI1_26923725_Chip-Seq_HPCs_Mouse0.91371159
166NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89158437
167NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89158437
168STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.89135295
169RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88894448
170EZH2_27294783_Chip-Seq_ESCs_Mouse0.88706634
171WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88549944
172AR_21572438_ChIP-Seq_LNCaP_Human0.88534720
173SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.88529502
174STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86077836
175AR_25329375_ChIP-Seq_VCAP_Human0.85628046
176CBX2_22325352_ChIP-Seq_293T-Rex_Human0.85416758
177SMRT_27268052_Chip-Seq_Bcells_Human0.84964503
178GATA1_19941826_ChIP-Seq_K562_Human0.84353189
179FOXO3_23340844_ChIP-Seq_DLD1_Human0.84336932
180TBX20_22080862_ChIP-Seq_HEART_Mouse0.83468324
181TBX20_22328084_ChIP-Seq_HEART_Mouse0.83468324
182BCAT_22108803_ChIP-Seq_LS180_Human0.82648545
183SMC4_20622854_ChIP-Seq_HELA_Human0.82606418
184BRD4_25478319_ChIP-Seq_HGPS_Human0.82329101
185MTF2_20144788_ChIP-Seq_MESCs_Mouse0.82134773
186PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.81693883
187TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.81338236

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.76717783
2MP0001929_abnormal_gametogenesis5.20375262
3MP0008875_abnormal_xenobiotic_pharmacok5.09441442
4MP0009780_abnormal_chondrocyte_physiolo4.72021089
5MP0008877_abnormal_DNA_methylation4.66651144
6MP0002132_abnormal_respiratory_system4.27108929
7MP0002210_abnormal_sex_determination3.49812924
8MP0002653_abnormal_ependyma_morphology3.39580333
9MP0008789_abnormal_olfactory_epithelium3.27238635
10MP0002161_abnormal_fertility/fecundity3.07590775
11MP0001145_abnormal_male_reproductive2.95240216
12MP0005623_abnormal_meninges_morphology2.67866509
13MP0005408_hypopigmentation2.59478927
14MP0004019_abnormal_vitamin_homeostasis2.58359209
15MP0000653_abnormal_sex_gland2.55792339
16MP0002277_abnormal_respiratory_mucosa2.54717995
17MP0005248_abnormal_Harderian_gland2.30242101
18MP0002160_abnormal_reproductive_system2.12856061
19MP0005499_abnormal_olfactory_system2.12221559
20MP0005394_taste/olfaction_phenotype2.12221559
21MP0005670_abnormal_white_adipose2.09745972
22MP0000566_synostosis2.06965582
23MP0010234_abnormal_vibrissa_follicle2.02782439
24MP0005410_abnormal_fertilization14.6599854
25MP0002168_other_aberrant_phenotype1.89643166
26MP0003950_abnormal_plasma_membrane1.86633761
27MP0002909_abnormal_adrenal_gland1.84855885
28MP0009046_muscle_twitch1.80619329
29MP0001984_abnormal_olfaction1.73080402
30MP0003183_abnormal_peptide_metabolism1.68411584
31MP0002876_abnormal_thyroid_physiology1.60282115
32MP0003646_muscle_fatigue1.59819360
33MP0002282_abnormal_trachea_morphology1.56656083
34MP0005275_abnormal_skin_tensile1.53053068
35MP0000013_abnormal_adipose_tissue1.50952578
36MP0004272_abnormal_basement_membrane1.49193268
37MP0010678_abnormal_skin_adnexa1.48434464
38MP0001664_abnormal_digestion1.46420016
39MP0003279_aneurysm1.44860266
40MP0001485_abnormal_pinna_reflex1.43131384
41MP0009053_abnormal_anal_canal1.42813076
42MP0010030_abnormal_orbit_morphology1.33073978
43MP0000383_abnormal_hair_follicle1.32965452
44MP0002896_abnormal_bone_mineralization1.32133827
45MP0000015_abnormal_ear_pigmentation1.26792704
46MP0008057_abnormal_DNA_replication1.20955072
47MP0004133_heterotaxia1.18261056
48MP0005395_other_phenotype1.16798084
49MP0000678_abnormal_parathyroid_gland1.15256220
50MP0003879_abnormal_hair_cell1.12926381
51MP0002249_abnormal_larynx_morphology1.10489100
52MP0001849_ear_inflammation1.08803349
53MP0005389_reproductive_system_phenotype1.08426292
54MP0005220_abnormal_exocrine_pancreas1.08092858
55MP0005551_abnormal_eye_electrophysiolog1.07765158
56MP0008058_abnormal_DNA_repair1.06542228
57MP0000371_diluted_coat_color1.05879492
58MP0005253_abnormal_eye_physiology1.05359660
59MP0002233_abnormal_nose_morphology1.01827841
60MP0005164_abnormal_response_to1.01773172
61MP0003011_delayed_dark_adaptation1.00603738
62MP0001944_abnormal_pancreas_morphology0.99727630
63MP0003656_abnormal_erythrocyte_physiolo0.99393292
64MP0001986_abnormal_taste_sensitivity0.99238555
65MP0005171_absent_coat_pigmentation0.97986025
66MP0004233_abnormal_muscle_weight0.96347170
67MP0005647_abnormal_sex_gland0.91517360
68MP0002136_abnormal_kidney_physiology0.91396868
69MP0005165_increased_susceptibility_to0.90486370
70MP0009384_cardiac_valve_regurgitation0.90136511
71MP0003941_abnormal_skin_development0.87666961
72MP0001765_abnormal_ion_homeostasis0.85397334
73MP0000681_abnormal_thyroid_gland0.85140481
74MP0001293_anophthalmia0.84985894
75MP0001270_distended_abdomen0.84890796
76MP0004883_abnormal_blood_vessel0.84132888
77MP0002163_abnormal_gland_morphology0.83696004
78MP0005365_abnormal_bile_salt0.82815752
79MP0004142_abnormal_muscle_tone0.82066908
80MP0003252_abnormal_bile_duct0.81765188
81MP0000639_abnormal_adrenal_gland0.79967456
82MP0005423_abnormal_somatic_nervous0.78947783
83MP0006276_abnormal_autonomic_nervous0.78817455
84MP0005379_endocrine/exocrine_gland_phen0.77918564
85MP0005083_abnormal_biliary_tract0.76977567
86MP0001299_abnormal_eye_distance/0.76537658
87MP0001346_abnormal_lacrimal_gland0.76461010
88MP0003329_amyloid_beta_deposits0.75389756
89MP0005508_abnormal_skeleton_morphology0.74894004
90MP0004134_abnormal_chest_morphology0.74598350
91MP0003115_abnormal_respiratory_system0.74292030
92MP0003091_abnormal_cell_migration0.73174743
93MP0005391_vision/eye_phenotype0.72776431
94MP0003136_yellow_coat_color0.69729042
95MP0008995_early_reproductive_senescence0.69351098
96MP0002098_abnormal_vibrissa_morphology0.69044793
97MP0006072_abnormal_retinal_apoptosis0.68898542
98MP0002735_abnormal_chemical_nociception0.68776506
99MP0001963_abnormal_hearing_physiology0.68694509
100MP0000613_abnormal_salivary_gland0.67332087
101MP0001324_abnormal_eye_pigmentation0.66994372
102MP0003878_abnormal_ear_physiology0.62938346
103MP0005377_hearing/vestibular/ear_phenot0.62938346
104MP0004036_abnormal_muscle_relaxation0.62920734
105MP0003566_abnormal_cell_adhesion0.61248139
106MP0000733_abnormal_muscle_development0.60122787
107MP0002060_abnormal_skin_morphology0.59436868
108MP0005023_abnormal_wound_healing0.59402289
109MP0003633_abnormal_nervous_system0.59043819
110MP0000163_abnormal_cartilage_morphology0.58909106
111MP0005195_abnormal_posterior_eye0.58415562
112MP0004270_analgesia0.58088849
113MP0003172_abnormal_lysosome_physiology0.58013730
114MP0010094_abnormal_chromosome_stability0.57752201
115MP0002116_abnormal_craniofacial_bone0.56189896
116MP0003634_abnormal_glial_cell0.55303306
117MP0003786_premature_aging0.54665329
118MP0008007_abnormal_cellular_replicative0.53320741
119MP0000920_abnormal_myelination0.50702935
120MP0003942_abnormal_urinary_system0.48590810
121MP0003861_abnormal_nervous_system0.47618552
122MP0003631_nervous_system_phenotype0.47109720
123MP0003690_abnormal_glial_cell0.46985307
124MP0003699_abnormal_female_reproductive0.46338359
125MP0002152_abnormal_brain_morphology0.46114009
126MP0002229_neurodegeneration0.46030417
127MP0001440_abnormal_grooming_behavior0.45358645
128MP0001661_extended_life_span0.43831857
129MP0002822_catalepsy0.43719550
130MP0002102_abnormal_ear_morphology0.42971960
131MP0002272_abnormal_nervous_system0.42627218
132MP0000749_muscle_degeneration0.42412479
133MP0004043_abnormal_pH_regulation0.42303026
134MP0000358_abnormal_cell_content/0.42029006
135MP0004742_abnormal_vestibular_system0.41915507
136MP0002234_abnormal_pharynx_morphology0.41667653
137MP0000462_abnormal_digestive_system0.37889676
138MP0005646_abnormal_pituitary_gland0.37617903
139MP0002092_abnormal_eye_morphology0.37177033
140MP0005636_abnormal_mineral_homeostasis0.35278362
141MP0001764_abnormal_homeostasis0.34363644
142MP0002572_abnormal_emotion/affect_behav0.33918733
143MP0000751_myopathy0.33612426
144MP0002295_abnormal_pulmonary_circulatio0.33527666
145MP0002928_abnormal_bile_duct0.32420520
146MP0000631_abnormal_neuroendocrine_gland0.32192302
147MP0002752_abnormal_somatic_nervous0.31903635
148MP0000534_abnormal_ureter_morphology0.31802333
149MP0003283_abnormal_digestive_organ0.31669051
150MP0000049_abnormal_middle_ear0.31527930
151MP0000778_abnormal_nervous_system0.29815842
152MP0001119_abnormal_female_reproductive0.29029322
153MP0002882_abnormal_neuron_morphology0.28987946
154MP0002638_abnormal_pupillary_reflex0.28586313
155MP0000432_abnormal_head_morphology0.28156301
156MP0001502_abnormal_circadian_rhythm0.27702186
157MP0001727_abnormal_embryo_implantation0.27236253
158MP0002084_abnormal_developmental_patter0.26646971
159MP0002736_abnormal_nociception_after0.26598992
160MP0001529_abnormal_vocalization0.26417855
161MP0008932_abnormal_embryonic_tissue0.26321645
162MP0002108_abnormal_muscle_morphology0.26293383
163MP0005503_abnormal_tendon_morphology0.25961791
164MP0000955_abnormal_spinal_cord0.25589317
165MP0002269_muscular_atrophy0.25495025
166MP0001730_embryonic_growth_arrest0.25198953
167MP0008438_abnormal_cutaneous_collagen0.24621641
168MP0000428_abnormal_craniofacial_morphol0.23871421
169MP0003948_abnormal_gas_homeostasis0.23156344
170MP0000604_amyloidosis0.22759006

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)8.93532338
2Abnormal respiratory epithelium morphology (HP:0012253)8.72524579
3Abnormal respiratory motile cilium morphology (HP:0005938)8.72524579
4Rhinitis (HP:0012384)8.22148294
5Chronic bronchitis (HP:0004469)7.07910183
6Infertility (HP:0000789)5.69858567
7Nasal polyposis (HP:0100582)5.66457865
8Bronchiectasis (HP:0002110)4.72292287
9Abnormality of the nasal mucosa (HP:0000433)4.70303768
10Nephronophthisis (HP:0000090)4.47273856
11Bronchitis (HP:0012387)4.27467490
12Male infertility (HP:0003251)3.50437798
13Recurrent sinusitis (HP:0011108)3.39861681
14Abnormality of the renal medulla (HP:0100957)3.34319681
15Medial flaring of the eyebrow (HP:0010747)3.31600688
16Recurrent otitis media (HP:0000403)3.18139022
17Chronic hepatic failure (HP:0100626)3.06926241
18Abnormality of midbrain morphology (HP:0002418)3.01737059
19Molar tooth sign on MRI (HP:0002419)3.01737059
20Atelectasis (HP:0100750)2.87596643
21Abnormal spermatogenesis (HP:0008669)2.80302817
22Hyperactive renin-angiotensin system (HP:0000841)2.79099409
23Tubulointerstitial nephritis (HP:0001970)2.75674295
24Microglossia (HP:0000171)2.60766728
25Pancreatic fibrosis (HP:0100732)2.58837441
26Fibular hypoplasia (HP:0003038)2.58068518
27Postaxial foot polydactyly (HP:0001830)2.54301485
28Tubular atrophy (HP:0000092)2.53183659
29Tubulointerstitial abnormality (HP:0001969)2.48284273
30Recurrent bronchitis (HP:0002837)2.40505695
31Decreased circulating renin level (HP:0003351)2.37642134
32Median cleft lip (HP:0000161)2.33050428
33Abnormality of the lower motor neuron (HP:0002366)2.27409968
34Gonadotropin excess (HP:0000837)2.23335291
35Gait imbalance (HP:0002141)2.22534958
36Congenital primary aphakia (HP:0007707)2.21379053
37Congenital hepatic fibrosis (HP:0002612)2.19956388
38Chronic otitis media (HP:0000389)2.16753076
39Tubulointerstitial fibrosis (HP:0005576)2.12092415
40Short ribs (HP:0000773)2.08712813
41Aplasia/Hypoplasia of the tongue (HP:0010295)2.05126178
42Genital tract atresia (HP:0001827)2.02339514
43Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.7986457
44Dynein arm defect of respiratory motile cilia (HP:0012255)11.7254834
45Absent/shortened dynein arms (HP:0200106)11.7254834
46Abnormal respiratory motile cilium physiology (HP:0012261)10.3340618
47Azoospermia (HP:0000027)1.98972568
48Postaxial hand polydactyly (HP:0001162)1.97623470
49Abnormality of the dental root (HP:0006486)1.97200437
50Taurodontia (HP:0000679)1.97200437
51Abnormality of permanent molar morphology (HP:0011071)1.97200437
52Nephrogenic diabetes insipidus (HP:0009806)1.96601045
53Cone-rod dystrophy (HP:0000548)1.94725618
54Facial cleft (HP:0002006)1.93575320
55Abnormality of dentin (HP:0010299)1.92844223
56Impulsivity (HP:0100710)1.92572367
57Stage 5 chronic kidney disease (HP:0003774)1.89457515
58Abnormality of molar morphology (HP:0011070)1.86859355
59Abnormality of molar (HP:0011077)1.86859355
60Bile duct proliferation (HP:0001408)1.84665939
61Abnormal biliary tract physiology (HP:0012439)1.84665939
62Oculomotor apraxia (HP:0000657)1.82413409
63Abnormal drinking behavior (HP:0030082)1.80768621
64Polydipsia (HP:0001959)1.80768621
65Impaired proprioception (HP:0010831)1.80545162
66Abnormality of the dental pulp (HP:0006479)1.80473779
67Nuclear cataract (HP:0100018)1.80103641
68Dyschromatopsia (HP:0007641)1.79417441
69Amyotrophic lateral sclerosis (HP:0007354)1.78667871
70Renal dysplasia (HP:0000110)1.75215652
71True hermaphroditism (HP:0010459)1.74321220
72Vaginal atresia (HP:0000148)1.74178324
73Aplasia/Hypoplasia of the lens (HP:0008063)1.74170281
74Decreased central vision (HP:0007663)1.74085532
75J-shaped sella turcica (HP:0002680)1.73110502
76Cystic liver disease (HP:0006706)1.70775564
77Vascular tortuosity (HP:0004948)1.67254339
78Anencephaly (HP:0002323)1.66635971
79Hypoplasia of the capital femoral epiphysis (HP:0003090)1.66133500
80Poor coordination (HP:0002370)1.63871864
81Absent frontal sinuses (HP:0002688)1.62846478
82Chronic sinusitis (HP:0011109)1.62023350
83Bell-shaped thorax (HP:0001591)1.61962746
84Aplasia/Hypoplasia of the fibula (HP:0006492)1.60927307
85Arterial tortuosity (HP:0005116)1.60386599
86Furrowed tongue (HP:0000221)1.58372029
87Supernumerary spleens (HP:0009799)1.57826956
88Male pseudohermaphroditism (HP:0000037)1.56336858
89Cholecystitis (HP:0001082)1.55985255
90Abnormal gallbladder physiology (HP:0012438)1.55985255
91Hyperkalemia (HP:0002153)1.53604477
92Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.51660940
93Abnormality of the renal cortex (HP:0011035)1.51659114
94Abnormality of renin-angiotensin system (HP:0000847)1.49560446
95Abnormality of renal excretion (HP:0011036)1.49187056
96Glucose intolerance (HP:0000833)1.46627126
97Sclerocornea (HP:0000647)1.42682333
98Nephropathy (HP:0000112)1.41543592
99Vertebral arch anomaly (HP:0008438)1.40443953
100Hand muscle atrophy (HP:0009130)1.40329045
101Menstrual irregularities (HP:0000858)1.39162782
102Short thorax (HP:0010306)1.38221172
103Occipital encephalocele (HP:0002085)1.36988884
104Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.36211518
105Abnormality of the frontal sinuses (HP:0002687)1.35564816
106Neurofibrillary tangles (HP:0002185)1.35518770
107Choroideremia (HP:0001139)1.35457037
108Short tibia (HP:0005736)1.35171676
109Delayed CNS myelination (HP:0002188)1.34971503
110Renal salt wasting (HP:0000127)1.34507956
111Camptodactyly of toe (HP:0001836)1.32332636
112Absent epiphyses (HP:0010577)1.30219765
113Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.30219765
114Abnormality of saccadic eye movements (HP:0000570)1.29996546
115Pachygyria (HP:0001302)1.29349789
116Broad distal phalanx of finger (HP:0009836)1.28724455
117Spinal muscular atrophy (HP:0007269)1.28597877
118Pancreatic cysts (HP:0001737)1.28570372
119Vertebral clefting (HP:0008428)1.28253071
120Subcapsular cataract (HP:0000523)1.27744775
121Spastic tetraparesis (HP:0001285)1.27004754
122Hyperaldosteronism (HP:0000859)1.25768030
123Selective tooth agenesis (HP:0001592)1.25711656
124Popliteal pterygium (HP:0009756)1.25513091
125Abnormal urine output (HP:0012590)1.24631191
126Deformed sella turcica (HP:0002681)1.24559982
127Aplasia/Hypoplasia of the tibia (HP:0005772)1.24526942
128Preaxial hand polydactyly (HP:0001177)1.24118260
129Abnormality of the distal phalanges of the toes (HP:0010182)1.21156822
130Abnormality of the anterior horn cell (HP:0006802)1.21017426
131Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.20471156
132Central scotoma (HP:0000603)1.18403220
133Asplenia (HP:0001746)1.14443255
134Striae distensae (HP:0001065)1.12930056
135Aplasia/Hypoplasia of the spleen (HP:0010451)1.12172558
136Mitral stenosis (HP:0001718)1.12062690
137Retinitis pigmentosa (HP:0000510)1.12019861
138Stridor (HP:0010307)1.10831006
139Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.09705472
140Nephritis (HP:0000123)1.07821672
141Upper limb amyotrophy (HP:0009129)1.06626634
142Distal upper limb amyotrophy (HP:0007149)1.06626634
143Short nail (HP:0001799)1.05809523
144Albinism (HP:0001022)1.04475667
145Rhizomelia (HP:0008905)1.04225376
146Spinal cord compression (HP:0002176)1.03752520

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.32174773
2PDK48.32174773
3PDK25.54980346
4TESK15.02921319
5MST44.26832721
6PRKD34.26525256
7EPHA24.08863737
8ICK3.34420021
9STK392.92438833
10PTK2B2.82463469
11PNCK2.68825058
12WNK42.66250427
13MAPK152.40066652
14FRK2.38892052
15MAP3K32.22586871
16NME12.06075544
17SMG12.00368587
18MAP3K21.64536174
19MAPKAPK31.53745284
20STK381.42566646
21NEK21.37785241
22CLK11.29920981
23STK101.25532495
24TRPM71.25098039
25MYLK1.19501971
26STK241.16106631
27EEF2K1.15718741
28WNK11.12688649
29EPHA31.01840025
30RIPK11.01557525
31TAF11.00721167
32PLK20.96603339
33PDK10.95848926
34TYRO30.95402712
35TRIB30.94951558
36DYRK1B0.91844352
37EIF2AK10.91691142
38STK30.91042595
39SCYL20.88186762
40ERBB30.88169897
41PRKCI0.87961915
42CDK120.87749169
43STK38L0.83562301
44TBK10.81384437
45NEK90.81344235
46LATS10.81298444
47LMTK20.79730002
48FGFR30.79689136
49MST1R0.78928966
50PASK0.78730170
51MAP2K20.74957796
52FER0.74763037
53DYRK30.73157766
54LRRK20.70379766
55RIPK40.68511686
56TTK0.67880812
57PRKAA20.64652746
58TLK10.63607918
59MAPK70.63260633
60HIPK20.62074401
61WEE10.61269680
62CCNB10.60091436
63NTRK20.59343551
64MAP3K70.57350197
65GRK70.57348368
66CAMK1G0.55757184
67NEK60.55534720
68PDPK10.50975540
69BMPR20.50844299
70CHEK20.50836903
71NTRK30.49836309
72ERBB20.48894664
73ABL20.48830362
74TESK20.48820290
75PINK10.47523248
76CHEK10.47187980
77ROCK10.46781126
78CAMKK20.45688089
79RPS6KA20.45633753
80CAMK2D0.45106774
81SGK30.44788019
82CDC70.44396475
83MAP2K10.44139617
84PAK30.44097170
85VRK20.44046683
86PAK20.43028263
87LATS20.41634989
88ADRBK10.41250484
89PAK10.40853835
90INSRR0.40239132
91MAPK110.39909756
92ATR0.39591008
93IRAK10.38869109
94MELK0.38641534
95AKT20.38462637
96STK40.36658073
97SGK10.35941335
98ATM0.34812654
99ACVR1B0.34610158
100MUSK0.34329649
101SGK20.34013562
102OBSCN0.33079936
103PRKCG0.32214856
104PRKCE0.31902542
105PTK20.31890930
106MAPKAPK50.31437940
107CDC42BPA0.30713246
108PKN10.30120385
109MAP3K120.28720608
110MAP2K70.27006574
111RPS6KB10.24908748
112MTOR0.22050638
113MARK20.20210338
114PRKG10.20019529
115BRAF0.19168246
116MAP2K60.19146536
117PLK10.17596544
118MAP3K40.16989341
119PRKAA10.16824577
120CAMK2A0.16384648
121MARK10.16052240
122BRSK20.16018344
123CSNK2A10.15592311
124OXSR10.15239932
125BCR0.15131545
126PRKCZ0.14633192
127PAK60.12621367
128GRK10.12473895
129CSNK1D0.12207487
130PRKDC0.11953709
131GSK3A0.11938217
132CSK0.11019326
133EPHB10.10490469
134CDK10.10432574
135GSK3B0.10412629
136PLK40.10183587
137STK160.09494300
138CSNK2A20.09476474
139PBK0.09131289
140PRKACG0.09084405
141CAMKK10.08892041
142MAPK80.08889144
143CDK30.08755834
144MAPK100.08399505
145PRKACB0.07771512
146BUB10.07582653
147PRKCQ0.07564384
148MAP3K100.07099394
149CDK140.06613756
150PRKACA0.06331338
151PRKCA0.06249177
152CDK150.06152287
153CDK20.06072567
154WNK30.05640987
155PRKCB0.05394702
156UHMK10.05312564
157PDGFRB0.05183909
158AURKA0.04960056
159BRSK10.04835273
160CAMK2G0.04698579
161CDK180.03955822
162BMPR1B0.03580900
163INSR0.02874438
164SRC0.02798599
165PAK40.02529694

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.69996214
2Histidine metabolism_Homo sapiens_hsa003403.94083066
3Phenylalanine metabolism_Homo sapiens_hsa003603.86257909
4Pyruvate metabolism_Homo sapiens_hsa006203.83445379
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.75964403
6Fatty acid biosynthesis_Homo sapiens_hsa000613.57937451
7Propanoate metabolism_Homo sapiens_hsa006403.45763561
8Tyrosine metabolism_Homo sapiens_hsa003503.10974130
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.76434935
10Linoleic acid metabolism_Homo sapiens_hsa005912.76165216
11beta-Alanine metabolism_Homo sapiens_hsa004102.71948548
12Pentose phosphate pathway_Homo sapiens_hsa000302.59398243
13Basal transcription factors_Homo sapiens_hsa030222.58846159
14Glucagon signaling pathway_Homo sapiens_hsa049222.45005446
15Huntingtons disease_Homo sapiens_hsa050162.15561302
16Retinol metabolism_Homo sapiens_hsa008302.05050503
17Dorso-ventral axis formation_Homo sapiens_hsa043201.95973215
18Fanconi anemia pathway_Homo sapiens_hsa034601.90186234
19Selenocompound metabolism_Homo sapiens_hsa004501.81351181
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.81275591
21Ether lipid metabolism_Homo sapiens_hsa005651.80545500
22Peroxisome_Homo sapiens_hsa041461.73068316
23Oocyte meiosis_Homo sapiens_hsa041141.69816975
24Glycerolipid metabolism_Homo sapiens_hsa005611.67426780
25PPAR signaling pathway_Homo sapiens_hsa033201.67425800
26Glycerophospholipid metabolism_Homo sapiens_hsa005641.58843314
27ECM-receptor interaction_Homo sapiens_hsa045121.57403620
28Amphetamine addiction_Homo sapiens_hsa050311.56608105
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.56593911
30Carbohydrate digestion and absorption_Homo sapiens_hsa049731.56019815
31Caffeine metabolism_Homo sapiens_hsa002321.52994614
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.52497450
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.49576450
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.47856111
35Cardiac muscle contraction_Homo sapiens_hsa042601.37516893
36Glycosaminoglycan degradation_Homo sapiens_hsa005311.35033387
37Mineral absorption_Homo sapiens_hsa049781.34865420
38Fructose and mannose metabolism_Homo sapiens_hsa000511.33683337
39Carbon metabolism_Homo sapiens_hsa012001.31965410
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.29031748
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.28715492
42Maturity onset diabetes of the young_Homo sapiens_hsa049501.24418183
43Renin secretion_Homo sapiens_hsa049241.20998791
44Steroid hormone biosynthesis_Homo sapiens_hsa001401.19098689
45Fatty acid metabolism_Homo sapiens_hsa012121.18588896
46Purine metabolism_Homo sapiens_hsa002301.18586356
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.15813495
48Fat digestion and absorption_Homo sapiens_hsa049751.15009219
49Phototransduction_Homo sapiens_hsa047441.10280445
50Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.09539024
51mRNA surveillance pathway_Homo sapiens_hsa030151.08111136
52Butanoate metabolism_Homo sapiens_hsa006501.07907101
53Renin-angiotensin system_Homo sapiens_hsa046141.03857652
54Protein digestion and absorption_Homo sapiens_hsa049741.02071832
55Starch and sucrose metabolism_Homo sapiens_hsa005001.00256946
56Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99989018
57Taste transduction_Homo sapiens_hsa047420.98753811
58Biosynthesis of amino acids_Homo sapiens_hsa012300.98736525
59Notch signaling pathway_Homo sapiens_hsa043300.97517138
60Sulfur metabolism_Homo sapiens_hsa009200.97397708
61Arachidonic acid metabolism_Homo sapiens_hsa005900.96515222
62Glutathione metabolism_Homo sapiens_hsa004800.94386401
63Circadian rhythm_Homo sapiens_hsa047100.91481808
64Hedgehog signaling pathway_Homo sapiens_hsa043400.90709595
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90374714
66Fatty acid degradation_Homo sapiens_hsa000710.87959666
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87858905
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87151116
69Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85480192
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84737175
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.83838271
72Adherens junction_Homo sapiens_hsa045200.83275287
73Amoebiasis_Homo sapiens_hsa051460.83181488
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82094759
75Choline metabolism in cancer_Homo sapiens_hsa052310.78395464
76Dilated cardiomyopathy_Homo sapiens_hsa054140.77854889
77RNA transport_Homo sapiens_hsa030130.76526167
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.74565030
79Focal adhesion_Homo sapiens_hsa045100.73975580
80Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73611306
81Chemical carcinogenesis_Homo sapiens_hsa052040.69926370
82Estrogen signaling pathway_Homo sapiens_hsa049150.69284584
83Hippo signaling pathway_Homo sapiens_hsa043900.66725644
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66284543
85cAMP signaling pathway_Homo sapiens_hsa040240.65540008
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.65291743
87Long-term potentiation_Homo sapiens_hsa047200.63360036
88Insulin secretion_Homo sapiens_hsa049110.62757999
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62704544
90Calcium signaling pathway_Homo sapiens_hsa040200.60856091
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.60740700
92Complement and coagulation cascades_Homo sapiens_hsa046100.59866299
93Fatty acid elongation_Homo sapiens_hsa000620.57130968
94Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57118089
95Gap junction_Homo sapiens_hsa045400.56312290
96Thyroid hormone synthesis_Homo sapiens_hsa049180.56218822
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.56003401
98Collecting duct acid secretion_Homo sapiens_hsa049660.55363064
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53753476
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.52527666
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.50009571
102Bile secretion_Homo sapiens_hsa049760.49009362
103Basal cell carcinoma_Homo sapiens_hsa052170.48194705
104Metabolic pathways_Homo sapiens_hsa011000.47213455
105Serotonergic synapse_Homo sapiens_hsa047260.46183620
106Hepatitis C_Homo sapiens_hsa051600.46149885
107Antigen processing and presentation_Homo sapiens_hsa046120.44852486
108Circadian entrainment_Homo sapiens_hsa047130.44006922
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.43409744
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.42682362
111Folate biosynthesis_Homo sapiens_hsa007900.42364251
112AMPK signaling pathway_Homo sapiens_hsa041520.41862579
113Pancreatic secretion_Homo sapiens_hsa049720.41371024
114Glutamatergic synapse_Homo sapiens_hsa047240.40418841
115Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39902550
116Cocaine addiction_Homo sapiens_hsa050300.38619497
117Sphingolipid metabolism_Homo sapiens_hsa006000.38609903
118ABC transporters_Homo sapiens_hsa020100.38398308
119Proteoglycans in cancer_Homo sapiens_hsa052050.37552489
120Melanogenesis_Homo sapiens_hsa049160.37327132
121Tryptophan metabolism_Homo sapiens_hsa003800.35274495
122Prostate cancer_Homo sapiens_hsa052150.35265829
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.35050735
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34627867
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33111027
126Oxytocin signaling pathway_Homo sapiens_hsa049210.33107189
127Olfactory transduction_Homo sapiens_hsa047400.32913542
128Endometrial cancer_Homo sapiens_hsa052130.32696967
129Insulin resistance_Homo sapiens_hsa049310.32364079
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32273722
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32023942
132Homologous recombination_Homo sapiens_hsa034400.30932714
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30713451
134Systemic lupus erythematosus_Homo sapiens_hsa053220.30602970
135Small cell lung cancer_Homo sapiens_hsa052220.30455001
136Endocytosis_Homo sapiens_hsa041440.29338417
137Cyanoamino acid metabolism_Homo sapiens_hsa004600.28239241
138Salivary secretion_Homo sapiens_hsa049700.28037502
139Pyrimidine metabolism_Homo sapiens_hsa002400.27953903
140Wnt signaling pathway_Homo sapiens_hsa043100.26595667
141Alcoholism_Homo sapiens_hsa050340.26564204
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26269861
143TGF-beta signaling pathway_Homo sapiens_hsa043500.24716632
144Alzheimers disease_Homo sapiens_hsa050100.24308794
145Gastric acid secretion_Homo sapiens_hsa049710.24108970
146Lysine degradation_Homo sapiens_hsa003100.23677122
147Drug metabolism - other enzymes_Homo sapiens_hsa009830.23613601
148Tight junction_Homo sapiens_hsa045300.23575899
149Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23270138
150Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.23136085
151Inositol phosphate metabolism_Homo sapiens_hsa005620.22669888
152Synaptic vesicle cycle_Homo sapiens_hsa047210.22100046

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