CCDC88A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.75981754
2presynaptic membrane assembly (GO:0097105)5.16750957
3neuron cell-cell adhesion (GO:0007158)5.03477471
4central nervous system myelination (GO:0022010)5.03380751
5axon ensheathment in central nervous system (GO:0032291)5.03380751
6presynaptic membrane organization (GO:0097090)4.92678383
7nucleobase catabolic process (GO:0046113)4.48935926
8cerebral cortex radially oriented cell migration (GO:0021799)4.13470101
9interkinetic nuclear migration (GO:0022027)4.02434737
10neuron recognition (GO:0008038)4.02147045
11ionotropic glutamate receptor signaling pathway (GO:0035235)3.97783966
12axonal fasciculation (GO:0007413)3.73677755
13glutamate receptor signaling pathway (GO:0007215)3.67928815
14postsynaptic membrane organization (GO:0001941)3.61134238
15negative regulation of neurotransmitter transport (GO:0051589)3.51865525
16regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.50043963
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.48954301
18limb bud formation (GO:0060174)3.46895030
19cell migration in hindbrain (GO:0021535)3.41205127
20startle response (GO:0001964)3.36751548
21dendritic spine morphogenesis (GO:0060997)3.34371828
22vocalization behavior (GO:0071625)3.33203814
23positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.31634697
24dendrite morphogenesis (GO:0048813)3.29364843
25central nervous system projection neuron axonogenesis (GO:0021952)3.25368241
26regulation of synapse structural plasticity (GO:0051823)3.25155656
27negative regulation of neurotransmitter secretion (GO:0046929)3.20969482
28protein localization to synapse (GO:0035418)3.19787005
29L-amino acid import (GO:0043092)3.19044591
30positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.10598769
31synaptic transmission, glutamatergic (GO:0035249)3.09638361
32gamma-aminobutyric acid signaling pathway (GO:0007214)3.09244572
33positive regulation of synapse assembly (GO:0051965)3.05567712
34transmission of nerve impulse (GO:0019226)3.04813716
35long-chain fatty acid biosynthetic process (GO:0042759)3.03017847
36negative regulation of synaptic transmission, GABAergic (GO:0032229)2.96184608
37cell proliferation in forebrain (GO:0021846)2.94510584
38nucleus localization (GO:0051647)2.92986880
39regulation of glutamate receptor signaling pathway (GO:1900449)2.92757693
40negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.91997696
41negative regulation of translation, ncRNA-mediated (GO:0040033)2.91997696
42regulation of translation, ncRNA-mediated (GO:0045974)2.91997696
43cerebellar granule cell differentiation (GO:0021707)2.89002863
44amino acid import (GO:0043090)2.88807543
45neuron-neuron synaptic transmission (GO:0007270)2.88659947
46protein polyglutamylation (GO:0018095)2.87422322
47mitochondrion transport along microtubule (GO:0047497)2.87229071
48establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.87229071
49regulation of respiratory system process (GO:0044065)2.85692265
50oligodendrocyte differentiation (GO:0048709)2.84548246
51regulation of pigment cell differentiation (GO:0050932)2.83325609
52positive regulation of synapse maturation (GO:0090129)2.82757715
53forebrain neuron differentiation (GO:0021879)2.82719328
54microtubule anchoring (GO:0034453)2.79660210
55neuronal stem cell maintenance (GO:0097150)2.79406493
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.78836217
57membrane depolarization during action potential (GO:0086010)2.78362828
58neuron remodeling (GO:0016322)2.77728791
59layer formation in cerebral cortex (GO:0021819)2.77021349
60positive regulation of potassium ion transmembrane transport (GO:1901381)2.75986021
61myelination (GO:0042552)2.75463718
62cilium or flagellum-dependent cell motility (GO:0001539)2.73644117
63regulation of synapse maturation (GO:0090128)2.73054540
64epithelial cell differentiation involved in kidney development (GO:0035850)2.72760746
65regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.72125777
66negative regulation of cytosolic calcium ion concentration (GO:0051481)2.71266561
67retinal cone cell development (GO:0046549)2.71216130
68neuronal action potential (GO:0019228)2.70871590
69negative regulation of protein localization to cell surface (GO:2000009)2.70138715
70central nervous system neuron axonogenesis (GO:0021955)2.69896181
71dendrite development (GO:0016358)2.69695160
72behavioral response to nicotine (GO:0035095)2.68702587
73G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.68648958
74membrane assembly (GO:0071709)2.68191509
75axon ensheathment (GO:0008366)2.67781427
76ensheathment of neurons (GO:0007272)2.67781427
77regulation of respiratory gaseous exchange (GO:0043576)2.67491732
78cerebellar Purkinje cell differentiation (GO:0021702)2.67107887
79regulation of dendritic spine morphogenesis (GO:0061001)2.66622864
80regulation of short-term neuronal synaptic plasticity (GO:0048172)2.66278269
81eye photoreceptor cell differentiation (GO:0001754)2.65711474
82photoreceptor cell differentiation (GO:0046530)2.65711474
83regulation of synapse assembly (GO:0051963)2.65029906
84synapse assembly (GO:0007416)2.64765916
85synaptic vesicle maturation (GO:0016188)2.64485104
86retinal ganglion cell axon guidance (GO:0031290)2.64008403
87neuronal action potential propagation (GO:0019227)2.63437089
88negative regulation of astrocyte differentiation (GO:0048712)2.63363548
89locomotory exploration behavior (GO:0035641)2.61856408
90atrial cardiac muscle cell action potential (GO:0086014)2.60732955
91mechanosensory behavior (GO:0007638)2.57815992
92histone H3-K9 methylation (GO:0051567)2.57477469
93regulation of excitatory postsynaptic membrane potential (GO:0060079)2.55069685
94olfactory bulb development (GO:0021772)2.54607463
95neural tube formation (GO:0001841)2.54486654
96behavioral response to ethanol (GO:0048149)2.54048477
97neuronal ion channel clustering (GO:0045161)2.53583218
98negative regulation of dendrite development (GO:2000171)2.51776227
99substrate-independent telencephalic tangential migration (GO:0021826)2.50763457
100substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.50763457
101synapsis (GO:0007129)2.50682860
102epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.50211508
103cAMP catabolic process (GO:0006198)2.49612563
104spinal cord development (GO:0021510)2.49030122
105cerebral cortex cell migration (GO:0021795)2.48744055
106membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.48600748
107auditory behavior (GO:0031223)2.48501597
108negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.48236165
109exploration behavior (GO:0035640)2.47727663
110regulation of dendritic spine development (GO:0060998)2.47118142
111synaptic vesicle exocytosis (GO:0016079)2.45946081
112gamma-aminobutyric acid transport (GO:0015812)2.44270089
113regulation of timing of cell differentiation (GO:0048505)2.42922841
114regulation of postsynaptic membrane potential (GO:0060078)2.42721611
115regulation of synaptic transmission, glutamatergic (GO:0051966)2.42505724
116retina layer formation (GO:0010842)2.41724389
117positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.41440500
118establishment of mitochondrion localization (GO:0051654)2.39709236
119negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.38997402
120regulation of vesicle fusion (GO:0031338)2.36662170
121adult walking behavior (GO:0007628)2.36278957
122positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.35494374
123negative regulation of axon extension (GO:0030517)2.34749858
124ventricular system development (GO:0021591)2.33814731
125long-term synaptic potentiation (GO:0060291)2.31742346
126regulation of long-term neuronal synaptic plasticity (GO:0048169)2.31452254
127asymmetric protein localization (GO:0008105)2.29538713
128positive regulation of dendritic spine development (GO:0060999)2.29355632
129positive regulation of dendritic spine morphogenesis (GO:0061003)2.28910403
130response to auditory stimulus (GO:0010996)2.28381903
131regulation of synaptic vesicle exocytosis (GO:2000300)2.27788637
132synapse organization (GO:0050808)2.27104309
133negative regulation of exocytosis (GO:0045920)2.25968012
134neurotransmitter-gated ion channel clustering (GO:0072578)2.25561275
135regulation of neuronal synaptic plasticity (GO:0048168)2.25504369
136nerve growth factor signaling pathway (GO:0038180)2.25240399
137epithelial cilium movement (GO:0003351)2.23757559
138cilium movement (GO:0003341)2.23580153
139regulation of synapse organization (GO:0050807)2.22991768
140axonogenesis (GO:0007409)2.22940600
141righting reflex (GO:0060013)2.20497229

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.39394783
2GBX2_23144817_ChIP-Seq_PC3_Human3.61129726
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.55828019
4ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45059986
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.43835434
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.31421265
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.30775788
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27876996
9TAF15_26573619_Chip-Seq_HEK293_Human2.23333898
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.22538962
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.18053672
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.12542541
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10652276
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.07565157
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.06307310
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.05404257
17RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03437371
18EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03437371
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01609194
20PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.00549180
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98425555
22P300_19829295_ChIP-Seq_ESCs_Human1.98015579
23GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97777189
24JARID2_20075857_ChIP-Seq_MESCs_Mouse1.95266648
25AR_21572438_ChIP-Seq_LNCaP_Human1.92516896
26FUS_26573619_Chip-Seq_HEK293_Human1.91976334
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90918748
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.85390407
29SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85021836
30RNF2_27304074_Chip-Seq_ESCs_Mouse1.83665254
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.82274498
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81807180
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.81094571
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79604071
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.77010736
36IGF1R_20145208_ChIP-Seq_DFB_Human1.76092642
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75272162
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.71031915
39SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.69804782
40SMAD3_21741376_ChIP-Seq_EPCs_Human1.68868537
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.67877091
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67369998
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.64110834
44SUZ12_27294783_Chip-Seq_ESCs_Mouse1.62654376
45HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.61474985
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.61199627
47ER_23166858_ChIP-Seq_MCF-7_Human1.59927937
48TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.55760626
49PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55106087
50* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53388255
51NANOG_18555785_Chip-Seq_ESCs_Mouse1.51705690
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50795958
53REST_21632747_ChIP-Seq_MESCs_Mouse1.50112910
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49577811
55RNF2_27304074_Chip-Seq_NSC_Mouse1.46893473
56VDR_22108803_ChIP-Seq_LS180_Human1.45416871
57POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40473449
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40473449
59* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.40274059
60STAT3_23295773_ChIP-Seq_U87_Human1.39361079
61EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38761298
62ZNF274_21170338_ChIP-Seq_K562_Hela1.37017118
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.36337294
64UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35105715
65EWS_26573619_Chip-Seq_HEK293_Human1.34952670
66MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34715125
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.34439165
68REST_18959480_ChIP-ChIP_MESCs_Mouse1.33122160
69AR_25329375_ChIP-Seq_VCAP_Human1.32911021
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.31666501
71TP53_18474530_ChIP-ChIP_U2OS_Human1.31545751
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31407656
73CMYC_18555785_Chip-Seq_ESCs_Mouse1.29191581
74DROSHA_22980978_ChIP-Seq_HELA_Human1.28271150
75TP53_16413492_ChIP-PET_HCT116_Human1.28155749
76* TCF4_23295773_ChIP-Seq_U87_Human1.27570256
77LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26979922
78CBP_20019798_ChIP-Seq_JUKART_Human1.26509550
79IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26509550
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26192215
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.25515441
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25000496
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.23863017
84RUNX2_22187159_ChIP-Seq_PCA_Human1.23776480
85P53_22387025_ChIP-Seq_ESCs_Mouse1.23585789
86BCAT_22108803_ChIP-Seq_LS180_Human1.23370230
87BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21830236
88SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21813616
89STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.20537254
90SALL1_21062744_ChIP-ChIP_HESCs_Human1.18716939
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.18471525
92* FLI1_21867929_ChIP-Seq_TH2_Mouse1.18114526
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17815866
94NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.17503681
95KDM2B_26808549_Chip-Seq_REH_Human1.17216297
96PRDM14_20953172_ChIP-Seq_ESCs_Human1.16245672
97SOX2_21211035_ChIP-Seq_LN229_Gbm1.15915883
98CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.15714465
99SOX9_26525672_Chip-Seq_HEART_Mouse1.13900663
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13147226
101EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.13032221
102CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.12863597
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.12167850
104POU5F1_16153702_ChIP-ChIP_HESCs_Human1.11843520
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11276597
106WT1_19549856_ChIP-ChIP_CCG9911_Human1.11141326
107P300_18555785_Chip-Seq_ESCs_Mouse1.10485608
108HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09770801
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09301667
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.09098093
111KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08624362
112* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08615847
113KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07646144
114YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07265748
115JUN_21703547_ChIP-Seq_K562_Human1.07090379
116* TAL1_26923725_Chip-Seq_HPCs_Mouse1.06759836
117STAT3_18555785_Chip-Seq_ESCs_Mouse1.06147808
118RING1B_27294783_Chip-Seq_NPCs_Mouse1.05842806
119AHR_22903824_ChIP-Seq_MCF-7_Human1.05419258
120SOX2_18555785_Chip-Seq_ESCs_Mouse1.04774404

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.41086746
2MP0005423_abnormal_somatic_nervous3.23894054
3MP0004859_abnormal_synaptic_plasticity3.21998579
4MP0004270_analgesia3.12081798
5MP0000778_abnormal_nervous_system2.85590750
6MP0003635_abnormal_synaptic_transmissio2.68286938
7MP0001486_abnormal_startle_reflex2.43932066
8MP0009046_muscle_twitch2.39874862
9MP0009745_abnormal_behavioral_response2.38896240
10MP0005171_absent_coat_pigmentation2.36777633
11MP0002063_abnormal_learning/memory/cond2.27330758
12MP0002064_seizures2.23172800
13MP0002572_abnormal_emotion/affect_behav2.13218510
14MP0001188_hyperpigmentation2.11003054
15MP0005409_darkened_coat_color2.03630728
16MP0002272_abnormal_nervous_system1.98615348
17MP0004742_abnormal_vestibular_system1.98134844
18MP0001968_abnormal_touch/_nociception1.95385457
19MP0002734_abnormal_mechanical_nocicepti1.94136286
20MP0000920_abnormal_myelination1.94110402
21MP0003136_yellow_coat_color1.86695651
22MP0003787_abnormal_imprinting1.85041683
23MP0001440_abnormal_grooming_behavior1.82304602
24MP0000569_abnormal_digit_pigmentation1.80158171
25MP0002184_abnormal_innervation1.76239033
26MP0003890_abnormal_embryonic-extraembry1.73419032
27MP0002822_catalepsy1.70786726
28MP0002735_abnormal_chemical_nociception1.70499766
29MP0002067_abnormal_sensory_capabilities1.67683903
30MP0005645_abnormal_hypothalamus_physiol1.64574527
31MP0006276_abnormal_autonomic_nervous1.59566710
32MP0002736_abnormal_nociception_after1.53846844
33MP0008057_abnormal_DNA_replication1.53212159
34MP0002102_abnormal_ear_morphology1.50406491
35MP0002733_abnormal_thermal_nociception1.47549460
36MP0002557_abnormal_social/conspecific_i1.45871218
37MP0000955_abnormal_spinal_cord1.44139830
38MP0005394_taste/olfaction_phenotype1.43548548
39MP0005499_abnormal_olfactory_system1.43548548
40MP0002882_abnormal_neuron_morphology1.40966905
41MP0005174_abnormal_tail_pigmentation1.39533674
42MP0001970_abnormal_pain_threshold1.39169067
43MP0004885_abnormal_endolymph1.37773209
44MP0001529_abnormal_vocalization1.37247058
45MP0008789_abnormal_olfactory_epithelium1.35429451
46MP0003634_abnormal_glial_cell1.32698447
47MP0005646_abnormal_pituitary_gland1.32589549
48MP0001905_abnormal_dopamine_level1.31165444
49MP0004924_abnormal_behavior1.30959413
50MP0005386_behavior/neurological_phenoty1.30959413
51MP0004134_abnormal_chest_morphology1.27841067
52MP0001299_abnormal_eye_distance/1.27423813
53MP0009250_abnormal_appendicular_skeleto1.27341995
54MP0000566_synostosis1.26288476
55MP0001984_abnormal_olfaction1.24851598
56MP0005410_abnormal_fertilization1.24378701
57MP0004133_heterotaxia1.23735384
58MP0003122_maternal_imprinting1.22713047
59MP0009780_abnormal_chondrocyte_physiolo1.19093369
60MP0001485_abnormal_pinna_reflex1.18059060
61MP0001501_abnormal_sleep_pattern1.17873162
62MP0002163_abnormal_gland_morphology1.17076639
63MP0003938_abnormal_ear_development1.16991612
64MP0001963_abnormal_hearing_physiology1.16458173
65MP0002152_abnormal_brain_morphology1.16450200
66MP0003690_abnormal_glial_cell1.15385168
67MP0003937_abnormal_limbs/digits/tail_de1.14648259
68MP0008569_lethality_at_weaning1.14257516
69MP0000049_abnormal_middle_ear1.13977651
70MP0000631_abnormal_neuroendocrine_gland1.12800192
71MP0005551_abnormal_eye_electrophysiolog1.12538158
72MP0001502_abnormal_circadian_rhythm1.11269662
73MP0003385_abnormal_body_wall1.10727833
74MP0006292_abnormal_olfactory_placode1.09561360
75MP0005623_abnormal_meninges_morphology1.08496715
76MP0002752_abnormal_somatic_nervous1.08083422
77MP0002066_abnormal_motor_capabilities/c1.08079744
78MP0000015_abnormal_ear_pigmentation1.06334531
79MP0001348_abnormal_lacrimal_gland1.06261733
80MP0004811_abnormal_neuron_physiology1.03525051
81MP0004142_abnormal_muscle_tone1.03480526
82MP0003631_nervous_system_phenotype1.03038991
83MP0003755_abnormal_palate_morphology1.02177917
84MP0002095_abnormal_skin_pigmentation1.02101987
85MP0000026_abnormal_inner_ear1.01811556
86MP0003633_abnormal_nervous_system1.01285543
87MP0005379_endocrine/exocrine_gland_phen1.00913316
88MP0002638_abnormal_pupillary_reflex1.00781867
89MP0003632_abnormal_nervous_system0.99626367
90MP0003121_genomic_imprinting0.96426470
91MP0002938_white_spotting0.96131766
92MP0003329_amyloid_beta_deposits0.95288895
93MP0003861_abnormal_nervous_system0.94685064
94MP0009379_abnormal_foot_pigmentation0.92885493
95MP0003950_abnormal_plasma_membrane0.91194583
96MP0002234_abnormal_pharynx_morphology0.90765810
97MP0003119_abnormal_digestive_system0.89025450
98MP0001346_abnormal_lacrimal_gland0.88855919
99MP0005187_abnormal_penis_morphology0.86592430
100MP0001177_atelectasis0.86358008
101MP0002229_neurodegeneration0.86121903
102MP0003698_abnormal_male_reproductive0.85143310
103MP0002928_abnormal_bile_duct0.83679906
104MP0002177_abnormal_outer_ear0.82930618
105MP0002009_preneoplasia0.81273530
106MP0005391_vision/eye_phenotype0.81197075
107MP0002909_abnormal_adrenal_gland0.81036970
108MP0006072_abnormal_retinal_apoptosis0.80397937
109MP0002116_abnormal_craniofacial_bone0.79287541
110MP0005253_abnormal_eye_physiology0.78422404
111MP0003935_abnormal_craniofacial_develop0.77957584
112MP0010386_abnormal_urinary_bladder0.76988984
113MP0003123_paternal_imprinting0.75946604
114MP0001293_anophthalmia0.75760177
115MP0001986_abnormal_taste_sensitivity0.75280413
116* MP0005195_abnormal_posterior_eye0.74607361
117MP0001943_abnormal_respiration0.73968896
118MP0002233_abnormal_nose_morphology0.73751966
119MP0002210_abnormal_sex_determination0.73233618
120MP0003646_muscle_fatigue0.73117196
121MP0004858_abnormal_nervous_system0.72293244
122MP0008877_abnormal_DNA_methylation0.71478400
123MP0002751_abnormal_autonomic_nervous0.71295403

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.03693344
2Dynein arm defect of respiratory motile cilia (HP:0012255)3.73442559
3Absent/shortened dynein arms (HP:0200106)3.73442559
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.29015538
5Epileptic encephalopathy (HP:0200134)3.21702168
6Papillary thyroid carcinoma (HP:0002895)3.19222926
7Degeneration of the lateral corticospinal tracts (HP:0002314)3.12016750
8Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.12016750
9Hyperventilation (HP:0002883)2.99087036
10Neurofibrillary tangles (HP:0002185)2.95918546
11Drooling (HP:0002307)2.95857500
12Excessive salivation (HP:0003781)2.95857500
13Action tremor (HP:0002345)2.92225728
14Hepatoblastoma (HP:0002884)2.89579166
15Abnormal ciliary motility (HP:0012262)2.85393232
16Broad-based gait (HP:0002136)2.82000456
17Absent speech (HP:0001344)2.80416471
18Abnormal respiratory motile cilium physiology (HP:0012261)2.79105963
19Genetic anticipation (HP:0003743)2.76824589
20Focal seizures (HP:0007359)2.75823744
21Aplasia involving bones of the extremities (HP:0009825)2.68966477
22Aplasia involving bones of the upper limbs (HP:0009823)2.68966477
23Aplasia of the phalanges of the hand (HP:0009802)2.68966477
24Pancreatic fibrosis (HP:0100732)2.68725804
25Oligodactyly (hands) (HP:0001180)2.67358877
26Abnormality of the corticospinal tract (HP:0002492)2.66500252
27Pachygyria (HP:0001302)2.62753415
28Amyotrophic lateral sclerosis (HP:0007354)2.57392279
29Abnormal respiratory epithelium morphology (HP:0012253)2.56378193
30Abnormal respiratory motile cilium morphology (HP:0005938)2.56378193
31Progressive cerebellar ataxia (HP:0002073)2.55997498
32Aplasia/Hypoplasia of the sternum (HP:0006714)2.48294055
33Protruding tongue (HP:0010808)2.48075072
34Hemiparesis (HP:0001269)2.47934278
35Widely spaced teeth (HP:0000687)2.47014042
36Thickened helices (HP:0000391)2.45370083
37Abnormality of the labia minora (HP:0012880)2.37478250
38Febrile seizures (HP:0002373)2.36792179
39Abnormality of incisor morphology (HP:0011063)2.34231796
40Abnormality of salivation (HP:0100755)2.31947654
41Chronic hepatic failure (HP:0100626)2.31326778
42Cortical dysplasia (HP:0002539)2.31109947
43True hermaphroditism (HP:0010459)2.30560620
44Neoplasm of the oral cavity (HP:0100649)2.26868825
45Urinary bladder sphincter dysfunction (HP:0002839)2.26553099
46Urinary urgency (HP:0000012)2.26443518
47Retinal dysplasia (HP:0007973)2.26052441
48Atonic seizures (HP:0010819)2.25104156
49Cerebral inclusion bodies (HP:0100314)2.22551750
50Midline defect of the nose (HP:0004122)2.21753279
51Lissencephaly (HP:0001339)2.21016719
52Cupped ear (HP:0000378)2.20449755
53Supranuclear gaze palsy (HP:0000605)2.16399463
54Intestinal atresia (HP:0011100)2.13827162
55Medulloblastoma (HP:0002885)2.13817956
56Clumsiness (HP:0002312)2.13597989
57Colon cancer (HP:0003003)2.13046886
58Abnormal hair whorl (HP:0010721)2.12091010
59Gait imbalance (HP:0002141)2.09690713
60Impaired vibration sensation in the lower limbs (HP:0002166)2.08158055
61Alacrima (HP:0000522)2.07878451
62Medial flaring of the eyebrow (HP:0010747)2.05720454
63Pancreatic cysts (HP:0001737)2.04660439
64Termporal pattern (HP:0011008)2.04325013
65Insidious onset (HP:0003587)2.04325013
66Progressive inability to walk (HP:0002505)2.03970214
67Polyphagia (HP:0002591)2.02643607
68Thyroid carcinoma (HP:0002890)2.01221861
69Aplasia/Hypoplasia of the tibia (HP:0005772)2.00940029
70Facial hemangioma (HP:0000329)1.99154626
71Short 4th metacarpal (HP:0010044)1.97694745
72Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.97694745
73Absent frontal sinuses (HP:0002688)1.97417736
74Intellectual disability, moderate (HP:0002342)1.96030862
75Intellectual disability, severe (HP:0010864)1.94771493
76Truncal ataxia (HP:0002078)1.93311531
77Inappropriate behavior (HP:0000719)1.93206590
78Aqueductal stenosis (HP:0002410)1.93200098
79Gaze-evoked nystagmus (HP:0000640)1.93100393
80Myokymia (HP:0002411)1.92846887
81Absent septum pellucidum (HP:0001331)1.92248531
82Megalencephaly (HP:0001355)1.91008695
83Nephronophthisis (HP:0000090)1.90994732
84Narrow forehead (HP:0000341)1.89852494
85Mixed hearing impairment (HP:0000410)1.89264577
86Dialeptic seizures (HP:0011146)1.89085757
87Abnormality of binocular vision (HP:0011514)1.89075503
88Diplopia (HP:0000651)1.89075503
89Blue irides (HP:0000635)1.88111832
90Dysmetria (HP:0001310)1.87990211
91Mutism (HP:0002300)1.87969325
92Poor eye contact (HP:0000817)1.87622947
93Decreased lacrimation (HP:0000633)1.86812576
94Long nose (HP:0003189)1.86717374
95Volvulus (HP:0002580)1.85306888
96Glioma (HP:0009733)1.83487888
97Dysdiadochokinesis (HP:0002075)1.82865615
98Inability to walk (HP:0002540)1.82774546
99Peripheral hypomyelination (HP:0007182)1.82359099
100Exotropia (HP:0000577)1.81777776
101Absence seizures (HP:0002121)1.79872028
102Gastroesophageal reflux (HP:0002020)1.78577185
103Type II lissencephaly (HP:0007260)1.78246705
104Optic nerve hypoplasia (HP:0000609)1.76886424
105Specific learning disability (HP:0001328)1.76814267
106Coronal craniosynostosis (HP:0004440)1.76668396
107Abnormality of the astrocytes (HP:0100707)1.76560649
108Astrocytoma (HP:0009592)1.76560649
109Genital tract atresia (HP:0001827)1.76094834
110Fair hair (HP:0002286)1.75920033
111Gastrointestinal atresia (HP:0002589)1.75804895
112Agitation (HP:0000713)1.75770270
113Submucous cleft hard palate (HP:0000176)1.75631794
114Spastic gait (HP:0002064)1.75374267
115Tented upper lip vermilion (HP:0010804)1.75154893
116Rhinitis (HP:0012384)1.74536209
117Limb dystonia (HP:0002451)1.74018733
118White forelock (HP:0002211)1.73085292
119Sensory axonal neuropathy (HP:0003390)1.72648702
120Abnormality of the septum pellucidum (HP:0007375)1.71918549
121Abnormality of the phalanges of the 2nd finger (HP:0009541)1.71168731
122Abnormality of the lower motor neuron (HP:0002366)1.70697951
123EEG with generalized epileptiform discharges (HP:0011198)1.70589857
124Impaired social interactions (HP:0000735)1.70549950
125Abnormal social behavior (HP:0012433)1.70549950
126Amblyopia (HP:0000646)1.70479228
127Vaginal atresia (HP:0000148)1.70175796
128Abnormality of midbrain morphology (HP:0002418)1.69770844
129Molar tooth sign on MRI (HP:0002419)1.69770844
130Hypoplasia of the corpus callosum (HP:0002079)1.69359680
131Congenital primary aphakia (HP:0007707)1.67191639
132Lower limb muscle weakness (HP:0007340)1.67008343
133Hypsarrhythmia (HP:0002521)1.66921582
134Nephrogenic diabetes insipidus (HP:0009806)1.66830827
135Generalized tonic-clonic seizures (HP:0002069)1.66814759
136Abnormality of the renal medulla (HP:0100957)1.66568636
137Oligodactyly (HP:0012165)1.66236571
138Stomach cancer (HP:0012126)1.65928774
139Scanning speech (HP:0002168)1.64977742
140Ankle clonus (HP:0011448)1.64288450
141Abnormality of the nasal septum (HP:0000419)1.64069932
142Neoplasm of the adrenal cortex (HP:0100641)1.63982244
143Poor coordination (HP:0002370)1.63485810
144Septo-optic dysplasia (HP:0100842)1.63350281
145Truncal obesity (HP:0001956)1.63337700
146Heterochromia iridis (HP:0001100)1.62491152
147Cutaneous finger syndactyly (HP:0010554)1.60879775
148Anteriorly placed anus (HP:0001545)1.60792986
149Microglossia (HP:0000171)1.59945722
150Aplasia/Hypoplasia of the lens (HP:0008063)1.59388112
151Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.57853455
152Buphthalmos (HP:0000557)1.57359574
153Epileptiform EEG discharges (HP:0011182)1.55754098

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.15467129
2MARK13.58837440
3PNCK2.89229913
4TNIK2.83397470
5EPHA42.60251817
6NTRK32.57106875
7FRK2.50187925
8STK392.28168577
9MAP2K72.18724385
10RIPK42.01082299
11MAP3K42.00321979
12BMPR1B1.99168008
13NTRK21.99124581
14MAPK131.97968756
15PKN11.94067816
16ACVR1B1.67866569
17BCR1.66467613
18MKNK21.54437123
19PINK11.52515431
20TAF11.51665050
21PLK21.51039753
22CAMK1G1.50434143
23OXSR11.49180020
24MUSK1.48515981
25DYRK21.40924991
26CCNB11.40650401
27SIK21.29066977
28FGR1.26046540
29WNK11.25123298
30ERBB31.22115407
31TIE11.22010461
32BMPR21.19050156
33PBK1.18996798
34YES11.17069442
35MAP4K21.16587887
36CSNK1A1L1.13580555
37PAK61.12495461
38CAMKK21.11275195
39MKNK11.10289897
40FGFR21.09617515
41CDK191.09377102
42MINK11.08434700
43UHMK11.08378982
44DYRK1A1.06873475
45SGK2231.03528011
46SGK4941.03528011
47CSNK1G21.00863613
48NEK60.99574560
49CDK50.98179654
50PHKG10.97464084
51PHKG20.97464084
52FES0.96015162
53NEK20.95865024
54CAMK2A0.95629180
55PRKCE0.94930456
56STK38L0.94468937
57PRPF4B0.91416902
58CDK30.91394893
59CAMK2B0.91092834
60ZAK0.90951872
61CSNK1G30.84421241
62NTRK10.83396142
63INSRR0.83378440
64DMPK0.82639834
65SGK10.81482990
66CLK10.80963523
67IRAK20.79804041
68NUAK10.77699710
69KSR10.77559591
70PLK40.76464837
71MAP3K140.76448769
72WNK40.75498778
73GRK70.75103105
74MAP3K60.73804061
75MAP2K40.72912288
76MARK20.71747658
77WNK30.71583404
78PAK30.71456133
79CAMKK10.70346750
80MAP3K90.69451065
81CSNK1G10.68187264
82AKT30.67528522
83PTK2B0.65349709
84SGK30.64965270
85MAPKAPK50.64817203
86ROCK20.63611581
87TLK10.63595113
88PRKG10.61837135
89CSNK1E0.61068568
90CAMK2D0.59621567
91SGK20.59593449
92PRKCQ0.59159536
93CDC70.58444777
94MAP3K130.57590719
95IRAK10.56080945
96DDR20.55322615
97ADRBK20.54360991
98TYRO30.53929747
99PRKCG0.53851831
100ADRBK10.53071175
101PIK3CA0.52946866
102BRD40.52758207
103EIF2AK20.50485715
104ERBB40.50468166
105CDK140.50086192
106CAMK1D0.49349031
107TEC0.48803881
108EPHB10.48035550
109RPS6KA30.47306944
110PRKCZ0.47096014
111CDK180.46627310
112PRKACB0.46320534
113GRK50.45839036
114CAMK40.45391692
115CDK150.45272665
116ATM0.44764321
117WEE10.44460823
118CAMK10.44163994
119EPHB20.43129491
120TGFBR10.41861590
121PRKDC0.41105988
122STK110.40489857
123MAPK100.40224561
124FYN0.39878511
125ROCK10.39279680
126STK30.38658066
127GSK3B0.38603228
128DAPK20.37823513
129SIK30.37624356
130CDK11A0.37102083
131DYRK30.36163810
132PRKACA0.35632942
133PDGFRB0.34972893
134CSNK1D0.34900143
135CDK10.34497525
136RPS6KB10.34437087

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.18232688
2Glutamatergic synapse_Homo sapiens_hsa047242.26648509
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.24834558
4GABAergic synapse_Homo sapiens_hsa047272.07736314
5Morphine addiction_Homo sapiens_hsa050322.06019001
6Circadian entrainment_Homo sapiens_hsa047131.93663325
7Axon guidance_Homo sapiens_hsa043601.91274624
8Serotonergic synapse_Homo sapiens_hsa047261.90346044
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.79000227
10Long-term depression_Homo sapiens_hsa047301.76273939
11Long-term potentiation_Homo sapiens_hsa047201.67494015
12Taste transduction_Homo sapiens_hsa047421.65163448
13Amphetamine addiction_Homo sapiens_hsa050311.64258148
14Renin secretion_Homo sapiens_hsa049241.59192508
15Dopaminergic synapse_Homo sapiens_hsa047281.55659328
16Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51814218
17Salivary secretion_Homo sapiens_hsa049701.50802733
18Cocaine addiction_Homo sapiens_hsa050301.45624727
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43028298
20Cholinergic synapse_Homo sapiens_hsa047251.38752899
21Olfactory transduction_Homo sapiens_hsa047401.38296883
22Dorso-ventral axis formation_Homo sapiens_hsa043201.37596023
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.34293299
24Ether lipid metabolism_Homo sapiens_hsa005651.30690302
25Basal transcription factors_Homo sapiens_hsa030221.27781931
26Insulin secretion_Homo sapiens_hsa049111.22259770
27Synaptic vesicle cycle_Homo sapiens_hsa047211.20218824
28Gastric acid secretion_Homo sapiens_hsa049711.15976885
29Phototransduction_Homo sapiens_hsa047441.15955728
30Oxytocin signaling pathway_Homo sapiens_hsa049211.15043327
31Calcium signaling pathway_Homo sapiens_hsa040201.11840472
32cAMP signaling pathway_Homo sapiens_hsa040241.08445210
33Steroid biosynthesis_Homo sapiens_hsa001001.06802220
34Gap junction_Homo sapiens_hsa045401.06330385
35ErbB signaling pathway_Homo sapiens_hsa040121.04964426
36GnRH signaling pathway_Homo sapiens_hsa049121.01784511
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99333455
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96991007
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96704571
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96546765
41Fanconi anemia pathway_Homo sapiens_hsa034600.95264690
42Collecting duct acid secretion_Homo sapiens_hsa049660.95044295
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.94971206
44Sphingolipid metabolism_Homo sapiens_hsa006000.94599331
45Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94242505
46African trypanosomiasis_Homo sapiens_hsa051430.93957675
47Ras signaling pathway_Homo sapiens_hsa040140.93330583
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93199278
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.92992222
50Autoimmune thyroid disease_Homo sapiens_hsa053200.91430689
51MAPK signaling pathway_Homo sapiens_hsa040100.90644446
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90474829
53Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89784583
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.88123564
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.88073715
56Sphingolipid signaling pathway_Homo sapiens_hsa040710.87154629
57Rheumatoid arthritis_Homo sapiens_hsa053230.86639696
58Melanogenesis_Homo sapiens_hsa049160.86471783
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86102941
60Wnt signaling pathway_Homo sapiens_hsa043100.85325951
61Butanoate metabolism_Homo sapiens_hsa006500.83786242
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83056263
63Choline metabolism in cancer_Homo sapiens_hsa052310.81929579
64Type I diabetes mellitus_Homo sapiens_hsa049400.81890167
65Allograft rejection_Homo sapiens_hsa053300.81340742
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78915996
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.78787805
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78175975
69Renal cell carcinoma_Homo sapiens_hsa052110.77602162
70Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.76475794
71Estrogen signaling pathway_Homo sapiens_hsa049150.76153471
72Selenocompound metabolism_Homo sapiens_hsa004500.75139912
73Type II diabetes mellitus_Homo sapiens_hsa049300.75118125
74Non-homologous end-joining_Homo sapiens_hsa034500.74760313
75Glioma_Homo sapiens_hsa052140.72719233
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72201659
77Hedgehog signaling pathway_Homo sapiens_hsa043400.71555312
78Ovarian steroidogenesis_Homo sapiens_hsa049130.71289280
79Phagosome_Homo sapiens_hsa041450.70501862
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70384022
81Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69888000
82Graft-versus-host disease_Homo sapiens_hsa053320.68625616
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68360641
84mRNA surveillance pathway_Homo sapiens_hsa030150.65987688
85Chemokine signaling pathway_Homo sapiens_hsa040620.64514911
86Thyroid hormone synthesis_Homo sapiens_hsa049180.63772198
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63158147
88Hippo signaling pathway_Homo sapiens_hsa043900.62716720
89Dilated cardiomyopathy_Homo sapiens_hsa054140.62412834
90Rap1 signaling pathway_Homo sapiens_hsa040150.62348264
91Vibrio cholerae infection_Homo sapiens_hsa051100.61743116
92Asthma_Homo sapiens_hsa053100.61692741
93Melanoma_Homo sapiens_hsa052180.61160264
94Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.60628407
95Alcoholism_Homo sapiens_hsa050340.60163179
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59610963
97Lysine degradation_Homo sapiens_hsa003100.58884167
98Circadian rhythm_Homo sapiens_hsa047100.57982632
99Endometrial cancer_Homo sapiens_hsa052130.57960725
100Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.57080638
101Linoleic acid metabolism_Homo sapiens_hsa005910.56989087
102Pancreatic secretion_Homo sapiens_hsa049720.56515700
103alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56507718
104Cardiac muscle contraction_Homo sapiens_hsa042600.54804893
105Salmonella infection_Homo sapiens_hsa051320.53648404
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53498822
107ABC transporters_Homo sapiens_hsa020100.53304644
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.52788249
109Prolactin signaling pathway_Homo sapiens_hsa049170.51576699
110Alzheimers disease_Homo sapiens_hsa050100.50783181
111Prostate cancer_Homo sapiens_hsa052150.50555089
112beta-Alanine metabolism_Homo sapiens_hsa004100.48238771
113Basal cell carcinoma_Homo sapiens_hsa052170.48190933
114Colorectal cancer_Homo sapiens_hsa052100.47972290
115MicroRNAs in cancer_Homo sapiens_hsa052060.47922971
116TGF-beta signaling pathway_Homo sapiens_hsa043500.47664597
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47232415
118Regulation of autophagy_Homo sapiens_hsa041400.47122966
119NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47116925
120Viral myocarditis_Homo sapiens_hsa054160.46204323
121Homologous recombination_Homo sapiens_hsa034400.45562351
122Oocyte meiosis_Homo sapiens_hsa041140.42560114
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42042767
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41900885
125mTOR signaling pathway_Homo sapiens_hsa041500.41279433
126Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40630550
127Nitrogen metabolism_Homo sapiens_hsa009100.40043105
128Fatty acid biosynthesis_Homo sapiens_hsa000610.38877801
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38796142
130Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38367651
131ECM-receptor interaction_Homo sapiens_hsa045120.37801269
132Inositol phosphate metabolism_Homo sapiens_hsa005620.37392506
133Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36684682

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