CCDC69

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female gonad development (GO:2000194)8.60185789
2attachment of spindle microtubules to kinetochore (GO:0008608)7.47221329
3positive regulation of gamma-delta T cell activation (GO:0046645)6.28266481
4mitotic chromosome condensation (GO:0007076)6.09125225
5meiotic cell cycle (GO:0051321)5.99374719
6female gamete generation (GO:0007292)5.95949871
7mitotic metaphase plate congression (GO:0007080)5.86810261
8negative regulation of cell killing (GO:0031342)5.79334380
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.79334380
10regulation of DNA methylation (GO:0044030)5.38432909
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.36224030
12antigen processing and presentation of endogenous antigen (GO:0019883)5.25662038
13regulation of B cell receptor signaling pathway (GO:0050855)5.15338225
14piRNA metabolic process (GO:0034587)5.13767400
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.12304022
16negative regulation of meiotic cell cycle (GO:0051447)5.11920425
17metaphase plate congression (GO:0051310)5.06517069
18protein localization to kinetochore (GO:0034501)5.06049183
19regulation of meiosis (GO:0040020)5.03222353
20CENP-A containing nucleosome assembly (GO:0034080)4.90861860
21regulation of histone H3-K27 methylation (GO:0061085)4.82090140
22negative regulation of meiosis (GO:0045835)4.81216719
23regulation of gamma-delta T cell activation (GO:0046643)4.80612362
24establishment of chromosome localization (GO:0051303)4.73927124
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.72159672
26chromatin remodeling at centromere (GO:0031055)4.63502809
27protein localization to chromosome, centromeric region (GO:0071459)4.61608636
28regulation of gamma-delta T cell differentiation (GO:0045586)4.61252568
29B cell receptor signaling pathway (GO:0050853)4.57007989
30histone H2A monoubiquitination (GO:0035518)4.49305266
31maturation of 5.8S rRNA (GO:0000460)4.40590876
32DNA replication-independent nucleosome organization (GO:0034724)4.32956486
33DNA replication-independent nucleosome assembly (GO:0006336)4.32956486
34meiotic chromosome segregation (GO:0045132)4.28459216
35modulation by symbiont of host defense response (GO:0052031)4.26004473
36modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.26004473
37modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.26004473
38positive regulation by organism of defense response of other organism involved in symbiotic interact4.26004473
39modulation by symbiont of host immune response (GO:0052553)4.26004473
40positive regulation by symbiont of host defense response (GO:0052509)4.26004473
41positive thymic T cell selection (GO:0045059)4.25965130
42negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.14984030
43positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.06249526
44detection of other organism (GO:0098543)4.05562194
45protein K6-linked ubiquitination (GO:0085020)4.02652154
46histone exchange (GO:0043486)3.98206641
47detection of bacterium (GO:0016045)3.97568987
48positive regulation of B cell differentiation (GO:0045579)3.97270859
49protein localization to chromosome (GO:0034502)3.97234882
50DNA replication checkpoint (GO:0000076)3.94519860
51regulation of meiotic cell cycle (GO:0051445)3.93747364
52histone H2A ubiquitination (GO:0033522)3.91880022
53negative thymic T cell selection (GO:0045060)3.91646658
54negative T cell selection (GO:0043383)3.90388084
55negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.85825155
56negative regulation of DNA-templated transcription, elongation (GO:0032785)3.85825155
57negative regulation of lymphocyte mediated immunity (GO:0002707)3.84599852
58regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.84481206
59mitotic sister chromatid segregation (GO:0000070)3.83155946
60regulation of sister chromatid cohesion (GO:0007063)3.82313986
61germinal center formation (GO:0002467)3.82145229
62chromatin assembly or disassembly (GO:0006333)3.81806354
63regulation of B cell differentiation (GO:0045577)3.79737032
64oocyte maturation (GO:0001556)3.79694942
65neutrophil activation involved in immune response (GO:0002283)3.74927017
66macrophage activation involved in immune response (GO:0002281)3.72901724
67cellular extravasation (GO:0045123)3.72801954
68positive T cell selection (GO:0043368)3.71304512
69DNA damage induced protein phosphorylation (GO:0006975)3.66079930
70base-excision repair, AP site formation (GO:0006285)3.65654815
71regulation of spindle organization (GO:0090224)3.61225466
72negative regulation of erythrocyte differentiation (GO:0045647)3.61205451
73negative regulation of T cell mediated immunity (GO:0002710)3.60671881
74response to interleukin-15 (GO:0070672)3.60441561
75chromosome segregation (GO:0007059)3.60072093
76regulation of mitotic spindle organization (GO:0060236)3.58180505
77T cell selection (GO:0045058)3.56313033
78positive regulation of chromosome segregation (GO:0051984)3.55832378
79regulation of interferon-beta biosynthetic process (GO:0045357)3.55799453
80positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.55743591
81mitotic nuclear envelope disassembly (GO:0007077)3.51381993
82regulation of exit from mitosis (GO:0007096)3.51324519
83kinetochore organization (GO:0051383)3.46942718
84thymic T cell selection (GO:0045061)3.45291673
85leukocyte aggregation (GO:0070486)3.43822124
86regulation of RIG-I signaling pathway (GO:0039535)3.42846787
87negative regulation of leukocyte mediated immunity (GO:0002704)3.41948242
88DNA methylation involved in gamete generation (GO:0043046)3.40609138
89spindle checkpoint (GO:0031577)3.39565851
90detection of external biotic stimulus (GO:0098581)3.38206692
91pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.35891194
92DNA damage response, signal transduction resulting in transcription (GO:0042772)3.33868374
93response to peptidoglycan (GO:0032494)3.33127023
94T cell migration (GO:0072678)3.32235760
95DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.31723101
96male meiosis (GO:0007140)3.31650548
97tolerance induction (GO:0002507)3.31138754
98positive regulation of mitotic sister chromatid separation (GO:1901970)3.28900521
99positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.28900521
100positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.28900521
101regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.27842485
102negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.27011799
103membrane disassembly (GO:0030397)3.25271626
104nuclear envelope disassembly (GO:0051081)3.25271626
105negative regulation of histone methylation (GO:0031061)3.22938116
106kinetochore assembly (GO:0051382)3.22111374
107cellular response to interleukin-15 (GO:0071350)3.22106168
108negative regulation of interleukin-12 production (GO:0032695)3.19282658
109regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.17028644
110sister chromatid segregation (GO:0000819)3.14759882
111immunoglobulin mediated immune response (GO:0016064)3.14417631
112regulation of tolerance induction (GO:0002643)3.13473661
113positive regulation of granulocyte differentiation (GO:0030854)3.13442873
114establishment of spindle localization (GO:0051293)3.12539223
115negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.11078174
116positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.08640308
117muscle filament sliding (GO:0030049)3.08609458
118actin-myosin filament sliding (GO:0033275)3.08609458
119mitotic spindle checkpoint (GO:0071174)3.06457637
120detection of molecule of bacterial origin (GO:0032490)3.06189967
121negative regulation of cell division (GO:0051782)3.06169351
122response to type I interferon (GO:0034340)3.05868576
123type I interferon signaling pathway (GO:0060337)3.05734728
124cellular response to type I interferon (GO:0071357)3.05734728
125regulation of steroid hormone secretion (GO:2000831)3.05613939
126regulation of chromosome segregation (GO:0051983)3.03516242
127B cell homeostasis (GO:0001782)3.02992182
128regulation of T cell tolerance induction (GO:0002664)3.01603292
129negative regulation of phagocytosis (GO:0050765)3.01594275
130negative regulation of chromosome segregation (GO:0051985)3.00864493
131regulation of hypersensitivity (GO:0002883)2.99621020
132regulation of alpha-beta T cell proliferation (GO:0046640)2.99115208
133detection of biotic stimulus (GO:0009595)2.97572856
134microtubule anchoring (GO:0034453)2.97406465
135negative regulation of mitotic sister chromatid separation (GO:2000816)2.97317302
136negative regulation of mitotic sister chromatid segregation (GO:0033048)2.97317302
137negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.97317302
138negative regulation of sister chromatid segregation (GO:0033046)2.97317302
139DNA replication initiation (GO:0006270)2.97260673
140response to host immune response (GO:0052572)2.96813641
141response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.96813641
142regulation of germinal center formation (GO:0002634)2.96538546
143interferon-gamma-mediated signaling pathway (GO:0060333)2.95728520
144telomere maintenance via recombination (GO:0000722)2.94535286
145regulation of double-strand break repair via homologous recombination (GO:0010569)2.94490631
146negative regulation of nuclear division (GO:0051784)2.94319314
147regulation of mitotic metaphase/anaphase transition (GO:0030071)2.93469466
148antigen processing and presentation via MHC class Ib (GO:0002475)2.92404511
149defense response to protozoan (GO:0042832)2.92301965
150regulation of necroptotic process (GO:0060544)2.91826668
151regulation of mast cell degranulation (GO:0043304)2.91738471
152mitotic spindle assembly checkpoint (GO:0007094)2.91346613
153antigen receptor-mediated signaling pathway (GO:0050851)2.91055332
154microtubule nucleation (GO:0007020)2.89518023
155regulation of mitotic sister chromatid separation (GO:0010965)2.88509172
156regulation of mitotic sister chromatid segregation (GO:0033047)2.88509172
157regulation of sister chromatid segregation (GO:0033045)2.88509172
158positive regulation of megakaryocyte differentiation (GO:0045654)2.87459945
159positive regulation of Cdc42 GTPase activity (GO:0043089)2.86578367
160spindle assembly checkpoint (GO:0071173)2.86443040
161gene silencing by RNA (GO:0031047)2.86359097
162neutrophil activation (GO:0042119)2.85478642
163DNA strand elongation involved in DNA replication (GO:0006271)2.84776161
164myeloid cell activation involved in immune response (GO:0002275)2.84167946
165respiratory burst (GO:0045730)2.83584611
166regulation of dendritic cell antigen processing and presentation (GO:0002604)2.82480510
167regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.82379114
168positive regulation of tolerance induction (GO:0002645)2.82155309
169exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.82078820
170response to muramyl dipeptide (GO:0032495)2.82066723
171negative regulation of innate immune response (GO:0045824)2.81281803
172DNA alkylation (GO:0006305)2.80644512
173DNA methylation (GO:0006306)2.80644512
174negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.80144107
175response to host (GO:0075136)2.79914165
176response to host defenses (GO:0052200)2.79914165
177response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.79914165
178regulation of antigen processing and presentation (GO:0002577)2.79313670
179chaperone-mediated protein transport (GO:0072321)2.78864972
180B cell mediated immunity (GO:0019724)2.78265496
181monoubiquitinated protein deubiquitination (GO:0035520)2.78260555
182pyrimidine nucleotide catabolic process (GO:0006244)2.78052289
183folic acid-containing compound biosynthetic process (GO:0009396)2.77433088
184production of molecular mediator involved in inflammatory response (GO:0002532)2.75446782
185regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.75023983
186regulation of T cell mediated cytotoxicity (GO:0001914)2.74632175
187positive regulation of mast cell activation (GO:0033005)2.73507311
188negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.72584094
189negative regulation of T-helper cell differentiation (GO:0045623)2.72584094
190lymphocyte homeostasis (GO:0002260)2.71864535
191Peyers patch development (GO:0048541)2.70001299
192mucosal-associated lymphoid tissue development (GO:0048537)2.70001299
193activated T cell proliferation (GO:0050798)2.69144459
194T cell homeostasis (GO:0043029)2.68381120
195regulation of granulocyte differentiation (GO:0030852)2.67574328
196regulation of mast cell activation involved in immune response (GO:0033006)2.63668507
197negative regulation of adaptive immune response (GO:0002820)2.63642391
198interferon-gamma production (GO:0032609)2.63628549

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.90797057
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.58778407
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.38329978
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.30230677
5AR_21909140_ChIP-Seq_LNCAP_Human3.19601561
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.01870640
7* RUNX_20019798_ChIP-Seq_JUKART_Human3.01284667
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.89784871
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.76314991
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.60545126
11* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.55214207
12* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.32626608
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.25356464
14SPI1_23127762_ChIP-Seq_K562_Human2.18099280
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.16987885
16E2F1_21310950_ChIP-Seq_MCF-7_Human2.13721045
17VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.12357025
18* MYC_22102868_ChIP-Seq_BL_Human2.05525791
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.03520431
20KAP1_22055183_ChIP-Seq_ESCs_Mouse2.01856905
21SCL_19346495_ChIP-Seq_HPC-7_Human1.94333435
22MYC_18940864_ChIP-ChIP_HL60_Human1.93432165
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89443350
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88811537
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.85143354
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.84412890
27BRD4_27068464_Chip-Seq_AML-cells_Mouse1.82918977
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.79449101
29* MAF_26560356_Chip-Seq_TH2_Human1.78708476
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.78149189
31GABP_17652178_ChIP-ChIP_JURKAT_Human1.75811748
32SMAD_19615063_ChIP-ChIP_OVARY_Human1.75718573
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.69011054
34KDM2B_26808549_Chip-Seq_DND41_Human1.67929485
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.67116416
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.66775039
37GATA1_19941827_ChIP-Seq_MEL_Mouse1.66256892
38IRF8_21731497_ChIP-ChIP_J774_Mouse1.65700429
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.64602046
40NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.62048674
41MYB_21317192_ChIP-Seq_ERMYB_Mouse1.61073085
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.60392218
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58491102
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58223330
45* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57604803
46VDR_24787735_ChIP-Seq_THP-1_Human1.57411888
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.57410556
48FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55549577
49Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.53415418
50PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.50448007
51GABP_19822575_ChIP-Seq_HepG2_Human1.50137076
52VDR_23849224_ChIP-Seq_CD4+_Human1.49855637
53* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49233534
54VDR_21846776_ChIP-Seq_THP-1_Human1.48094225
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.48076741
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.47676198
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47389328
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42235882
59TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41426577
60RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40190757
61SPI1_23547873_ChIP-Seq_NB4_Human1.40088584
62GATA1_22025678_ChIP-Seq_K562_Human1.39119777
63MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.38775978
64GATA1_19941826_ChIP-Seq_K562_Human1.38617396
65EST1_17652178_ChIP-ChIP_JURKAT_Human1.38559972
66* MYB_26560356_Chip-Seq_TH2_Human1.37614462
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36595161
68UTX_26944678_Chip-Seq_JUKART_Human1.36562646
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.36428149
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.35007767
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32031994
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31439310
73CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30866825
74CIITA_25753668_ChIP-Seq_RAJI_Human1.29661212
75DCP1A_22483619_ChIP-Seq_HELA_Human1.28749500
76JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.28031120
77NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26903188
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.26570865
79FOXP3_21729870_ChIP-Seq_TREG_Human1.25385671
80EGR1_19374776_ChIP-ChIP_THP-1_Human1.24659320
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24218829
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24110453
83SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.24032317
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.23910443
85MYB_26560356_Chip-Seq_TH1_Human1.23694732
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22285843
87GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20997297
88MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20922447
89* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19654087
90NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.19362628
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.17803904
92RUNX1_26923725_Chip-Seq_HPCs_Mouse1.17673870
93PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17376772
94* PU_27001747_Chip-Seq_BMDM_Mouse1.17353783
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15847839
96LXR_22292898_ChIP-Seq_THP-1_Human1.14558678
97TCF7_22412390_ChIP-Seq_EML_Mouse1.14109727
98ETS1_20019798_ChIP-Seq_JURKAT_Human1.13808691
99ELK3_25401928_ChIP-Seq_HUVEC_Human1.13002986
100PPARA_22158963_ChIP-Seq_LIVER_Mouse1.12630074
101GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12511799
102MYC_18358816_ChIP-ChIP_MESCs_Mouse1.12366743
103E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11561187
104PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11086866
105BCL6_27268052_Chip-Seq_Bcells_Human1.10240601
106GATA2_21666600_ChIP-Seq_HMVEC_Human1.10159768
107TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.08643171
108TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07270422
109CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07104285
110* GATA3_27048872_Chip-Seq_THYMUS_Human1.07050092
111GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06486120
112E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.04945163
113MYC_19030024_ChIP-ChIP_MESCs_Mouse1.04651825
114SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04437954
115TBX20_22080862_ChIP-Seq_HEART_Mouse1.04179026
116TBX20_22328084_ChIP-Seq_HEART_Mouse1.04179026
117TP63_19390658_ChIP-ChIP_HaCaT_Human1.03272804
118KDM5A_27292631_Chip-Seq_BREAST_Human1.03149097
119GATA3_26560356_Chip-Seq_TH2_Human1.02678615
120PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02614586
121KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02260053
122GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02257953
123* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.02176784
124ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02125156
125RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01938194
126CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01897994
127FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.01801016
128* KDM2B_26808549_Chip-Seq_JURKAT_Human1.01562132
129PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01069920
130* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00424375
131STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.00397045
132EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.99996450
133TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99990926
134GATA2_19941826_ChIP-Seq_K562_Human0.99709187
135* BCOR_27268052_Chip-Seq_Bcells_Human0.99688599
136SPI1_20517297_ChIP-Seq_HL60_Human0.99081735
137MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.98591904
138RUNX1_22412390_ChIP-Seq_EML_Mouse0.97956910
139ELF1_17652178_ChIP-ChIP_JURKAT_Human0.97304795
140STAT4_19710469_ChIP-ChIP_TH1__Mouse0.97218937
141GATA1_26923725_Chip-Seq_HPCs_Mouse0.97133177
142MAF_26560356_Chip-Seq_TH1_Human0.96379516
143VDR_24763502_ChIP-Seq_THP-1_Human0.96122661
144CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.92820143
145KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92384425
146RXR_22158963_ChIP-Seq_LIVER_Mouse0.92254152
147CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91473436
148PU.1_20513432_ChIP-Seq_Bcells_Mouse0.90851397
149LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.89841284
150TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89378665
151CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89315273
152SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89297363
153CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.88937798
154FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.88708641
155* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88295778
156DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88215001
157ERG_20517297_ChIP-Seq_VCAP_Human0.86413145
158SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86093562
159ETS1_22383799_ChIP-Seq_G1ME_Mouse0.85922248
160HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.85267347
161PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84753462

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect5.26856230
2MP0005451_abnormal_body_composition4.75642021
3MP0003693_abnormal_embryo_hatching4.07488469
4MP0010094_abnormal_chromosome_stability3.98887053
5MP0003646_muscle_fatigue3.43038479
6MP0003077_abnormal_cell_cycle3.26605096
7MP0003111_abnormal_nucleus_morphology3.06178900
8MP0003303_peritoneal_inflammation3.05035021
9MP0008877_abnormal_DNA_methylation2.88164133
10MP0003763_abnormal_thymus_physiology2.81328745
11MP0004957_abnormal_blastocyst_morpholog2.76266367
12MP0002396_abnormal_hematopoietic_system2.67037638
13MP0001119_abnormal_female_reproductive2.61534003
14MP0003699_abnormal_female_reproductive2.34664960
15MP0005395_other_phenotype2.22931257
16MP0004130_abnormal_muscle_cell2.21191585
17MP0003828_pulmonary_edema2.07281917
18MP0008007_abnormal_cellular_replicative2.00411801
19MP0001929_abnormal_gametogenesis1.93497005
20MP0004036_abnormal_muscle_relaxation1.90702770
21MP0000490_abnormal_crypts_of1.89944491
22MP0002102_abnormal_ear_morphology1.88110746
23MP0002148_abnormal_hypersensitivity_rea1.86508267
24MP0003300_gastrointestinal_ulcer1.83191176
25MP0001835_abnormal_antigen_presentation1.77518417
26MP0002398_abnormal_bone_marrow1.76971574
27MP0000653_abnormal_sex_gland1.76868390
28MP0008057_abnormal_DNA_replication1.76833473
29MP0004145_abnormal_muscle_electrophysio1.73901316
30MP0002019_abnormal_tumor_incidence1.71037971
31MP0000751_myopathy1.70539935
32MP0000685_abnormal_immune_system1.69744790
33MP0004808_abnormal_hematopoietic_stem1.68866956
34MP0002653_abnormal_ependyma_morphology1.65438395
35MP0004084_abnormal_cardiac_muscle1.64624506
36MP0001800_abnormal_humoral_immune1.63663856
37MP0002210_abnormal_sex_determination1.58565689
38MP0005671_abnormal_response_to1.56296583
39MP0001533_abnormal_skeleton_physiology1.54855641
40MP0008058_abnormal_DNA_repair1.53422579
41MP0002166_altered_tumor_susceptibility1.52986600
42MP0006082_CNS_inflammation1.52985161
43MP0008932_abnormal_embryonic_tissue1.52086174
44MP0000689_abnormal_spleen_morphology1.51649511
45MP0003191_abnormal_cellular_cholesterol1.50648636
46MP0000465_gastrointestinal_hemorrhage1.49593797
47MP0005397_hematopoietic_system_phenotyp1.49544370
48MP0001545_abnormal_hematopoietic_system1.49544370
49MP0005408_hypopigmentation1.47938889
50MP0002132_abnormal_respiratory_system1.47162477
51MP0002332_abnormal_exercise_endurance1.44184687
52MP0001915_intracranial_hemorrhage1.41596487
53MP0009333_abnormal_splenocyte_physiolog1.39788179
54MP0000350_abnormal_cell_proliferation1.37813702
55MP0004947_skin_inflammation1.37732904
56MP0002722_abnormal_immune_system1.36268343
57MP0005666_abnormal_adipose_tissue1.34269863
58MP0000716_abnormal_immune_system1.33882999
59MP0002452_abnormal_antigen_presenting1.33634469
60MP0000749_muscle_degeneration1.33630706
61MP0002420_abnormal_adaptive_immunity1.33166886
62MP0005310_abnormal_salivary_gland1.32490900
63MP0005670_abnormal_white_adipose1.32140233
64MP0006292_abnormal_olfactory_placode1.30942574
65MP0001819_abnormal_immune_cell1.30812012
66MP0001873_stomach_inflammation1.29894556
67MP0000703_abnormal_thymus_morphology1.29449564
68MP0002723_abnormal_immune_serum1.28907904
69MP0004264_abnormal_extraembryonic_tissu1.28639933
70MP0004510_myositis1.24843053
71MP0003787_abnormal_imprinting1.23655950
72MP0002429_abnormal_blood_cell1.22890564
73MP0008469_abnormal_protein_level1.21207895
74MP0002106_abnormal_muscle_physiology1.20190169
75MP0004087_abnormal_muscle_fiber1.18037000
76MP0003866_abnormal_defecation1.17548016
77MP0001905_abnormal_dopamine_level1.15607223
78MP0004484_altered_response_of1.14538034
79MP0010368_abnormal_lymphatic_system1.14115383
80MP0005330_cardiomyopathy1.11972705
81MP0002161_abnormal_fertility/fecundity1.10790566
82MP0002006_tumorigenesis1.10487945
83MP0005464_abnormal_platelet_physiology1.10062904
84MP0002138_abnormal_hepatobiliary_system1.06353815
85MP0003121_genomic_imprinting1.05723787
86MP0009785_altered_susceptibility_to1.04797729
87MP0002971_abnormal_brown_adipose1.04102735
88MP0009278_abnormal_bone_marrow1.03730130
89MP0004381_abnormal_hair_follicle1.03604130
90MP0003045_fibrosis1.02695387
91MP0002009_preneoplasia1.02481123
92MP0009764_decreased_sensitivity_to1.02224860
93MP0008004_abnormal_stomach_pH1.01576368
94MP0005000_abnormal_immune_tolerance0.99653483
95MP0005166_decreased_susceptibility_to0.99570101
96MP0000759_abnormal_skeletal_muscle0.99362491
97MP0001145_abnormal_male_reproductive0.98711966
98MP0002998_abnormal_bone_remodeling0.98275305
99MP0002405_respiratory_system_inflammati0.97263358
100MP0010155_abnormal_intestine_physiology0.97262345
101MP0002837_dystrophic_cardiac_calcinosis0.96918477
102MP0006036_abnormal_mitochondrial_physio0.95479616
103MP0000313_abnormal_cell_death0.94943171
104MP0001697_abnormal_embryo_size0.94689711
105MP0001853_heart_inflammation0.94332338
106MP0003172_abnormal_lysosome_physiology0.94283806
107MP0000747_muscle_weakness0.94228168
108MP0002972_abnormal_cardiac_muscle0.94071378
109MP0009115_abnormal_fat_cell0.93529031
110MP0004883_abnormal_blood_vessel0.93245737
111MP0005025_abnormal_response_to0.93136842
112MP0000343_altered_response_to0.93060693
113MP0005375_adipose_tissue_phenotype0.91907147
114MP0001790_abnormal_immune_system0.91752383
115MP0005387_immune_system_phenotype0.91752383
116MP0001544_abnormal_cardiovascular_syste0.91679393
117MP0005385_cardiovascular_system_phenoty0.91679393
118MP0000858_altered_metastatic_potential0.91526123
119MP0003075_altered_response_to0.91466263
120MP0003221_abnormal_cardiomyocyte_apopto0.91109031
121MP0001730_embryonic_growth_arrest0.90884285
122MP0002933_joint_inflammation0.89310028
123MP0010234_abnormal_vibrissa_follicle0.88816983
124MP0005369_muscle_phenotype0.88663442
125MP0002419_abnormal_innate_immunity0.88531028
126MP0000249_abnormal_blood_vessel0.86941165
127MP0005620_abnormal_muscle_contractility0.86253543
128MP0008260_abnormal_autophagy0.84005629
129MP0003724_increased_susceptibility_to0.83759678
130MP0006054_spinal_hemorrhage0.83569944
131MP0003656_abnormal_erythrocyte_physiolo0.82952611
132MP0006138_congestive_heart_failure0.80952743
133MP0002269_muscular_atrophy0.80927206
134MP0002127_abnormal_cardiovascular_syste0.80417760
135MP0002877_abnormal_melanocyte_morpholog0.78119895
136MP0009697_abnormal_copulation0.77562542
137MP0005621_abnormal_cell_physiology0.76023076
138MP0002085_abnormal_embryonic_tissue0.75398292
139MP0005023_abnormal_wound_healing0.75344836
140MP0001919_abnormal_reproductive_system0.74923382
141MP0005380_embryogenesis_phenotype0.74377560
142MP0001672_abnormal_embryogenesis/_devel0.74377560
143MP0003123_paternal_imprinting0.72753594
144MP0003453_abnormal_keratinocyte_physiol0.70903300
145MP0001851_eye_inflammation0.69765012
146MP0000639_abnormal_adrenal_gland0.68829045
147MP0001845_abnormal_inflammatory_respons0.67969826
148MP0001529_abnormal_vocalization0.66854431
149MP0004185_abnormal_adipocyte_glucose0.65752632
150MP0003436_decreased_susceptibility_to0.65725023
151MP0009763_increased_sensitivity_to0.65199879
152MP0005174_abnormal_tail_pigmentation0.63510066
153MP0002080_prenatal_lethality0.62885401
154MP0000579_abnormal_nail_morphology0.61932880
155MP0006072_abnormal_retinal_apoptosis0.61658901
156MP0000477_abnormal_intestine_morphology0.61413195
157MP0003315_abnormal_perineum_morphology0.61063525

Predicted human phenotypes

RankGene SetZ-score
1Male infertility (HP:0003251)8.82849875
2Birth length less than 3rd percentile (HP:0003561)5.76996941
3Eczematoid dermatitis (HP:0000976)4.98575757
4Chromsome breakage (HP:0040012)4.46617394
5Muscle fiber inclusion bodies (HP:0100299)4.37861413
6Exercise-induced myalgia (HP:0003738)4.34866351
7Nemaline bodies (HP:0003798)4.30475099
8Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.18060083
9Breast hypoplasia (HP:0003187)3.98882950
10Aplastic anemia (HP:0001915)3.93646006
11Premature ovarian failure (HP:0008209)3.74016999
12Chromosomal breakage induced by crosslinking agents (HP:0003221)3.71686404
13Abnormality of macrophages (HP:0004311)3.67192091
14Recurrent gram-negative bacterial infections (HP:0005420)3.66569706
15Abnormality of the fingertips (HP:0001211)3.58703288
16Stomatitis (HP:0010280)3.56904385
17Combined immunodeficiency (HP:0005387)3.53260758
18Mediastinal lymphadenopathy (HP:0100721)3.47699210
19Muscle fiber splitting (HP:0003555)3.44531347
20Acute myeloid leukemia (HP:0004808)3.39341160
21Infertility (HP:0000789)3.39242764
22Papillary thyroid carcinoma (HP:0002895)3.37008536
23Vasculitis (HP:0002633)3.33178446
24Gastrointestinal infarctions (HP:0005244)3.28889406
25Colitis (HP:0002583)3.27292988
26Gastrointestinal stroma tumor (HP:0100723)3.24140957
27Patellar aplasia (HP:0006443)3.21267571
28Spontaneous hematomas (HP:0007420)3.20278094
29Cortical dysplasia (HP:0002539)3.19616543
30Pulmonary fibrosis (HP:0002206)3.17905931
31Thrombocytosis (HP:0001894)3.14585794
32Abnormality of lateral ventricle (HP:0030047)3.10126152
33Myelodysplasia (HP:0002863)3.09588515
34Inflammation of the large intestine (HP:0002037)3.08466808
35Cellulitis (HP:0100658)3.03779085
36Asymmetric septal hypertrophy (HP:0001670)3.02626979
37Gastrointestinal inflammation (HP:0004386)2.96871206
38Chest pain (HP:0100749)2.96401326
39Hyporeflexia of lower limbs (HP:0002600)2.95966184
40Rhabdomyolysis (HP:0003201)2.95397181
41Secondary amenorrhea (HP:0000869)2.95239966
42Abnormality of chromosome stability (HP:0003220)2.94418120
43Increased IgE level (HP:0003212)2.94185164
44Spondylolisthesis (HP:0003302)2.93546592
45Type 1 muscle fiber predominance (HP:0003803)2.93116755
46EMG: myopathic abnormalities (HP:0003458)2.90673981
47Aplasia/Hypoplasia of the patella (HP:0006498)2.88074303
48Chronic obstructive pulmonary disease (HP:0006510)2.87552043
49Obstructive lung disease (HP:0006536)2.87552043
50Difficulty running (HP:0009046)2.87397022
51Deep venous thrombosis (HP:0002625)2.85742647
52Centrally nucleated skeletal muscle fibers (HP:0003687)2.85649203
53Cholecystitis (HP:0001082)2.83376730
54Abnormal gallbladder physiology (HP:0012438)2.83376730
55T lymphocytopenia (HP:0005403)2.83189257
56Prolonged bleeding time (HP:0003010)2.82351287
57Recurrent sinusitis (HP:0011108)2.79678403
58Hypergonadotropic hypogonadism (HP:0000815)2.78896577
59Abnormality of skeletal muscle fiber size (HP:0012084)2.78615966
60Myositis (HP:0100614)2.77801575
61Rhabdomyosarcoma (HP:0002859)2.76410373
62Abnormality of T cell number (HP:0011839)2.74544787
63Abnormal delayed hypersensitivity skin test (HP:0002963)2.59404002
64Aplasia/Hypoplasia of the sternum (HP:0006714)2.56351232
65Type 2 muscle fiber atrophy (HP:0003554)2.53696648
66Abnormality of the prostate (HP:0008775)2.51925153
67Keratoconjunctivitis (HP:0001096)2.51493323
68Panhypogammaglobulinemia (HP:0003139)2.51017252
69Urticaria (HP:0001025)2.50808471
70Lymphopenia (HP:0001888)2.49246576
71Overlapping toe (HP:0001845)2.47955500
72Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.47936046
73Abnormality of alanine metabolism (HP:0010916)2.47936046
74Hyperalaninemia (HP:0003348)2.47936046
75Capillary hemangiomas (HP:0005306)2.47429897
76Subaortic stenosis (HP:0001682)2.47107652
77Abnormality of the left ventricular outflow tract (HP:0011103)2.47107652
78Muscle hypertrophy of the lower extremities (HP:0008968)2.44878521
79Papilloma (HP:0012740)2.44737091
80Verrucae (HP:0200043)2.44737091
81IgM deficiency (HP:0002850)2.44390873
82Facial hemangioma (HP:0000329)2.41822419
83Sudden death (HP:0001699)2.41387610
84Increased variability in muscle fiber diameter (HP:0003557)2.41038410
85Myopathic facies (HP:0002058)2.40546210
86Osteomyelitis (HP:0002754)2.40385724
87Hemoptysis (HP:0002105)2.40267460
88Recurrent viral infections (HP:0004429)2.39746278
89Muscle fiber atrophy (HP:0100295)2.39272386
90Gingivitis (HP:0000230)2.38406190
91Exercise-induced muscle cramps (HP:0003710)2.36627349
92Distal arthrogryposis (HP:0005684)2.34938963
93Myoglobinuria (HP:0002913)2.34341165
94Distal lower limb muscle weakness (HP:0009053)2.34200851
95Recurrent bacterial skin infections (HP:0005406)2.33944286
96Increased connective tissue (HP:0009025)2.33606424
97Neck muscle weakness (HP:0000467)2.33214305
98Abnormality of cells of the lymphoid lineage (HP:0012140)2.32438520
99Abnormality of the preputium (HP:0100587)2.32407791
100Abnormality of chromosome segregation (HP:0002916)2.31083560
101Arterial thrombosis (HP:0004420)2.28292558
102Ulnar deviation of the wrist (HP:0003049)2.27134292
103Fatigue (HP:0012378)2.26791332
104Granulocytopenia (HP:0001913)2.25666042
105Epistaxis (HP:0000421)2.24986305
106Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.24389992
107Recurrent abscess formation (HP:0002722)2.24141563
108Pustule (HP:0200039)2.23800604
109Increased IgM level (HP:0003496)2.21387164
110Small intestinal stenosis (HP:0012848)2.21254355
111Duodenal stenosis (HP:0100867)2.21254355
112Agammaglobulinemia (HP:0004432)2.19681490
113Oral leukoplakia (HP:0002745)2.19559007
114Restrictive lung disease (HP:0002091)2.18618212
115Sloping forehead (HP:0000340)2.18106719
116Clubbing of toes (HP:0100760)2.18080594
117Flat capital femoral epiphysis (HP:0003370)2.16132201
118Frequent falls (HP:0002359)2.14433984
119Calf muscle hypertrophy (HP:0008981)2.13708228
120Abnormality of T cell physiology (HP:0011840)2.12986196
121Nasal polyposis (HP:0100582)2.12404070
122Aplasia/Hypoplasia of the uvula (HP:0010293)2.12149053
123Severe combined immunodeficiency (HP:0004430)2.11148352
124Pulmonary embolism (HP:0002204)2.08050570
125Exertional dyspnea (HP:0002875)2.06917445
126Hypochromic anemia (HP:0001931)2.06698023
127Ventricular tachycardia (HP:0004756)2.05182100
128Sandal gap (HP:0001852)2.05138302
129Shawl scrotum (HP:0000049)2.03972552
130Retrobulbar optic neuritis (HP:0100654)2.03517359
131Optic neuritis (HP:0100653)2.03517359
132Muscle stiffness (HP:0003552)2.03228322
133Gingival bleeding (HP:0000225)2.02851100
134Abnormality of the endocardium (HP:0004306)2.02139370
135Thyroiditis (HP:0100646)2.01480305
136Autoimmune hemolytic anemia (HP:0001890)2.01439763
137Abnormality of the nasal mucosa (HP:0000433)1.98554047
138Arterial tortuosity (HP:0005116)1.98116774
139Meckel diverticulum (HP:0002245)1.97429858
140Recurrent cutaneous fungal infections (HP:0011370)1.97100347
141Chronic mucocutaneous candidiasis (HP:0002728)1.97100347
142Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.94935662
143Eosinophilia (HP:0001880)1.94149852
144Abnormality of the labia minora (HP:0012880)1.93763486
145IgG deficiency (HP:0004315)1.93541713
146Bone marrow hypocellularity (HP:0005528)1.92316261
147Insulin-resistant diabetes mellitus (HP:0000831)1.92197815
148Adrenal hypoplasia (HP:0000835)1.91722550
149Abnormality of T cells (HP:0002843)1.90158782
150Neoplasm of striated muscle (HP:0009728)1.89160463
151Prostate neoplasm (HP:0100787)1.88974070
152Medulloblastoma (HP:0002885)1.87098964
153Encephalitis (HP:0002383)1.86051802
154Abnormality of the ileum (HP:0001549)1.85062533
155Chronic otitis media (HP:0000389)1.85017604
156Abnormality of DNA repair (HP:0003254)1.84996623
157Hypoplastic iliac wings (HP:0002866)1.84299879
158Nonprogressive disorder (HP:0003680)1.81887633
159Thyroid carcinoma (HP:0002890)1.80232573
160Slender long bone (HP:0003100)1.80010531
161Recurrent bronchitis (HP:0002837)1.79601940
162Recurrent skin infections (HP:0001581)1.77038442
163Bronchitis (HP:0012387)1.76941709
164Recurrent fungal infections (HP:0002841)1.76750849
165Poikiloderma (HP:0001029)1.76550552
166Short thumb (HP:0009778)1.76355155
167Orchitis (HP:0100796)1.75702039
168Leukocytosis (HP:0001974)1.75567885
169Elevated erythrocyte sedimentation rate (HP:0003565)1.75253516
170Supernumerary spleens (HP:0009799)1.75032409
171Pulmonary infiltrates (HP:0002113)1.73837997
172Chronic bronchitis (HP:0004469)1.72951363
173Nephroblastoma (Wilms tumor) (HP:0002667)1.72364754
174Meningitis (HP:0001287)1.72265044
175Keratoconjunctivitis sicca (HP:0001097)1.70039998

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MOS5.66055780
2BMPR25.61718301
3TAOK35.34590990
4RIPK43.99424543
5MAP3K63.90326384
6PRPF4B3.18026639
7PLK42.98361902
8ERN12.89651145
9OBSCN2.82016664
10TTK2.80605434
11BLK2.79129336
12CDC72.74003805
13LATS12.55000201
14MAP3K132.47791763
15STK102.47408362
16MUSK2.22247377
17FES2.02641536
18CSK2.02214070
19EEF2K2.02178788
20IRAK41.98420876
21TTN1.98406268
22CDK81.95886043
23MAP4K11.88541821
24RAF11.77885173
25MAP3K141.71232286
26MAPK121.68266733
27CDK91.65780462
28MAP3K91.63336039
29LATS21.63181636
30KSR21.62594576
31TNK21.61286015
32TAOK11.60435565
33ARAF1.59273191
34NLK1.57597972
35GRK61.55293624
36BRAF1.53400224
37KIT1.52408707
38PIK3CG1.52165746
39JAK11.49393995
40ITK1.46187753
41BUB11.43319362
42NEK21.42497169
43HCK1.40559906
44ACVR1B1.37381501
45STK38L1.37267322
46MAP3K81.31277793
47TRIB31.27398640
48EPHB11.26595368
49MELK1.25303204
50PLK11.23202808
51MAP3K71.22489126
52JAK31.21795609
53MAP3K101.15706576
54MAP3K31.15238591
55MAP3K111.13835085
56ERBB41.11068683
57JAK21.09482517
58MAPK71.05365931
59MAP3K11.02207006
60CHEK20.98578162
61CDC42BPA0.97940547
62MAPKAPK30.97647193
63PDK10.95803732
64DYRK20.93062242
65LRRK20.93062002
66TEC0.92508309
67MARK30.91845180
68IKBKB0.90454275
69AURKB0.89769982
70SIK30.88419802
71STK30.82104200
72TAOK20.81634120
73CDK40.80409667
74PRKCQ0.80245721
75CSNK1G10.78749839
76PDPK10.77552844
77SIK20.77190513
78FGFR40.77132317
79FGFR30.76346085
80FGR0.75077597
81BTK0.73994725
82FLT30.73709694
83PKN20.71907013
84PHKG10.70640842
85PHKG20.70640842
86WEE10.68605975
87TGFBR20.68333176
88IRAK10.67413181
89TXK0.66599294
90TGFBR10.65856515
91RPS6KB20.65169242
92TYK20.63588612
93MAPK40.63257927
94RET0.63133810
95HIPK20.62260260
96MAPKAPK50.60456541
97IKBKE0.59642382
98SMG10.59373111
99EIF2AK10.56884465
100VRK10.56818055
101PRKD20.56767573
102ZAP700.56498035
103DMPK0.54848954
104TESK20.54590563
105CSF1R0.53899328
106ABL20.52356161
107SGK30.51326771
108EPHA30.51136714
109SIK10.50924232
110BRSK20.48918456
111CSNK1G30.48617888
112CAMKK20.48434183
113CDK70.48399265
114NUAK10.47891805
115CAMK40.47779391
116ATR0.47578460
117MATK0.46214755
118RPS6KL10.45486208
119RPS6KC10.45486208
120DYRK1B0.44195172
121RPS6KA40.43551115
122MAP2K60.43342947
123NEK90.42932602
124FYN0.42735244
125SGK20.42110291
126YES10.42018207
127AURKA0.41703452
128STK240.41064871
129RPS6KA60.39851161
130PRKD10.39783580
131MAP2K20.39593459
132PTK2B0.37328550
133SYK0.37020326
134PRKAA20.36260754
135MAPK130.35852025
136NEK10.34824907
137PIM10.34437029
138TBK10.34099264
139ATM0.33038533
140ABL10.32118208
141PINK10.31932303
142MAP3K120.30873457
143MAP3K50.30382678
144MAP2K70.29822906
145PRKD30.29548517
146CSNK1G20.28602171
147CHEK10.27093046
148TRPM70.25495374
149LCK0.25385034
150CHUK0.25125506
151MARK20.24006026
152MAPK110.23582046
153PRKAA10.23260161
154KSR10.23256331
155CSNK1A1L0.22749672
156STK40.20844543
157MAP2K30.20809056
158LYN0.19413752
159TYRO30.19010001
160BMPR1B0.18645496
161NME20.17936013
162CCNB10.17627687

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.97762782
2Cell cycle_Homo sapiens_hsa041103.87816540
3RNA degradation_Homo sapiens_hsa030183.64594514
4Base excision repair_Homo sapiens_hsa034103.38250830
5Basal transcription factors_Homo sapiens_hsa030223.27594696
6Ovarian steroidogenesis_Homo sapiens_hsa049133.10116207
7Allograft rejection_Homo sapiens_hsa053303.09213430
8Graft-versus-host disease_Homo sapiens_hsa053323.03847197
9Homologous recombination_Homo sapiens_hsa034403.00531410
10Autoimmune thyroid disease_Homo sapiens_hsa053202.91217099
11Non-homologous end-joining_Homo sapiens_hsa034502.85645098
12Mismatch repair_Homo sapiens_hsa034302.85306069
13Staphylococcus aureus infection_Homo sapiens_hsa051502.71110722
14Fanconi anemia pathway_Homo sapiens_hsa034602.28937941
15Type I diabetes mellitus_Homo sapiens_hsa049402.21697043
16Nucleotide excision repair_Homo sapiens_hsa034202.18270933
17Asthma_Homo sapiens_hsa053102.17084222
18Circadian rhythm_Homo sapiens_hsa047102.16155724
19Oocyte meiosis_Homo sapiens_hsa041142.15521547
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.00537726
21RNA polymerase_Homo sapiens_hsa030201.96202279
22p53 signaling pathway_Homo sapiens_hsa041151.93757569
23Pancreatic cancer_Homo sapiens_hsa052121.82163109
24Tuberculosis_Homo sapiens_hsa051521.80821943
25Primary immunodeficiency_Homo sapiens_hsa053401.80266412
26RNA transport_Homo sapiens_hsa030131.75985932
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.62693601
28Pyrimidine metabolism_Homo sapiens_hsa002401.59603034
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.45368912
30Folate biosynthesis_Homo sapiens_hsa007901.41316618
31Herpes simplex infection_Homo sapiens_hsa051681.40775024
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.17801567
33Linoleic acid metabolism_Homo sapiens_hsa005911.15186508
34alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.14850775
35Transcriptional misregulation in cancer_Homo sapiens_hsa052021.11153044
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.09908821
37B cell receptor signaling pathway_Homo sapiens_hsa046621.08703647
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.08435494
39Thyroid cancer_Homo sapiens_hsa052161.08261524
40Adipocytokine signaling pathway_Homo sapiens_hsa049201.07663151
41MicroRNAs in cancer_Homo sapiens_hsa052061.05337967
42mRNA surveillance pathway_Homo sapiens_hsa030151.04068440
43Prolactin signaling pathway_Homo sapiens_hsa049171.04014748
44Colorectal cancer_Homo sapiens_hsa052101.01124414
45Insulin resistance_Homo sapiens_hsa049311.00343728
46Shigellosis_Homo sapiens_hsa051311.00263131
47Spliceosome_Homo sapiens_hsa030400.96614726
48Ether lipid metabolism_Homo sapiens_hsa005650.96402658
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95932119
50Jak-STAT signaling pathway_Homo sapiens_hsa046300.95422376
51Hematopoietic cell lineage_Homo sapiens_hsa046400.92616409
52Purine metabolism_Homo sapiens_hsa002300.92358335
53HTLV-I infection_Homo sapiens_hsa051660.92331604
54Hepatitis B_Homo sapiens_hsa051610.91609055
55TGF-beta signaling pathway_Homo sapiens_hsa043500.91301270
56Hepatitis C_Homo sapiens_hsa051600.90631388
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88135914
58Pertussis_Homo sapiens_hsa051330.87221768
59NF-kappa B signaling pathway_Homo sapiens_hsa040640.86867329
60Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86458430
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.85861271
62Rheumatoid arthritis_Homo sapiens_hsa053230.85105880
63Vitamin B6 metabolism_Homo sapiens_hsa007500.83828802
64Measles_Homo sapiens_hsa051620.83557005
65Legionellosis_Homo sapiens_hsa051340.83116277
66Phagosome_Homo sapiens_hsa041450.79156429
67Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.78554435
68Caffeine metabolism_Homo sapiens_hsa002320.78197565
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78092224
70Insulin signaling pathway_Homo sapiens_hsa049100.78037263
71Platelet activation_Homo sapiens_hsa046110.77469081
72Leishmaniasis_Homo sapiens_hsa051400.75247249
73Notch signaling pathway_Homo sapiens_hsa043300.75237077
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.74729609
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73834222
76Chronic myeloid leukemia_Homo sapiens_hsa052200.73525891
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71365466
78Dilated cardiomyopathy_Homo sapiens_hsa054140.70070239
79Antigen processing and presentation_Homo sapiens_hsa046120.69180608
80Influenza A_Homo sapiens_hsa051640.68926163
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68504001
82Epstein-Barr virus infection_Homo sapiens_hsa051690.68450795
83Small cell lung cancer_Homo sapiens_hsa052220.67797953
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67348831
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66398153
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.65784706
87African trypanosomiasis_Homo sapiens_hsa051430.65287885
88Dorso-ventral axis formation_Homo sapiens_hsa043200.65025331
89FoxO signaling pathway_Homo sapiens_hsa040680.62516258
90Renal cell carcinoma_Homo sapiens_hsa052110.61366843
91AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61029493
92GnRH signaling pathway_Homo sapiens_hsa049120.60517944
93Apoptosis_Homo sapiens_hsa042100.60080416
94PPAR signaling pathway_Homo sapiens_hsa033200.59486990
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59010063
96VEGF signaling pathway_Homo sapiens_hsa043700.58486171
97Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58112413
98Other glycan degradation_Homo sapiens_hsa005110.57657211
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.56279661
100Toxoplasmosis_Homo sapiens_hsa051450.51599632
101Ribosome_Homo sapiens_hsa030100.50694641
102Vascular smooth muscle contraction_Homo sapiens_hsa042700.50467815
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.49633874
104Viral myocarditis_Homo sapiens_hsa054160.49468797
105Oxytocin signaling pathway_Homo sapiens_hsa049210.49443481
106T cell receptor signaling pathway_Homo sapiens_hsa046600.47921077
107TNF signaling pathway_Homo sapiens_hsa046680.47515665
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47441013
109Viral carcinogenesis_Homo sapiens_hsa052030.46884734
110Choline metabolism in cancer_Homo sapiens_hsa052310.45578573
111Acute myeloid leukemia_Homo sapiens_hsa052210.45422668
112Osteoclast differentiation_Homo sapiens_hsa043800.43775351
113Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43728843
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.42587744
115One carbon pool by folate_Homo sapiens_hsa006700.42251371
116Non-small cell lung cancer_Homo sapiens_hsa052230.41128923
117HIF-1 signaling pathway_Homo sapiens_hsa040660.40713637
118Endometrial cancer_Homo sapiens_hsa052130.40075151
119Inositol phosphate metabolism_Homo sapiens_hsa005620.37804940
120AMPK signaling pathway_Homo sapiens_hsa041520.36019683
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34816942
122Glycerolipid metabolism_Homo sapiens_hsa005610.34784713
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.33297379
124Type II diabetes mellitus_Homo sapiens_hsa049300.33038910
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.31441389
126Endocytosis_Homo sapiens_hsa041440.29788082
127Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28655321
128Toll-like receptor signaling pathway_Homo sapiens_hsa046200.27724410
129Arachidonic acid metabolism_Homo sapiens_hsa005900.27668469
130Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.27063615
131Chemokine signaling pathway_Homo sapiens_hsa040620.26307578
132MAPK signaling pathway_Homo sapiens_hsa040100.25389095
133Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23531917
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.22479875
135Pathways in cancer_Homo sapiens_hsa052000.22470299
136Malaria_Homo sapiens_hsa051440.21771241
137Ras signaling pathway_Homo sapiens_hsa040140.21720423
138Regulation of actin cytoskeleton_Homo sapiens_hsa048100.20184883
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.17899246
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17330314
141Glycosaminoglycan degradation_Homo sapiens_hsa005310.16312428
142mTOR signaling pathway_Homo sapiens_hsa041500.15560615
143Phospholipase D signaling pathway_Homo sapiens_hsa040720.15381845

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