CCDC65

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a sperm tail protein that is highly expressed in adult testis, spermatocytes and spermatids. The protein plays a critical role in the assembly of the nexin-dynein regulatory complex. Mutations in this gene result in primary ciliary dyskinesia. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)9.84925951
2motile cilium assembly (GO:0044458)9.70970778
3plasma membrane fusion (GO:0045026)9.27530966
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.23771662
5binding of sperm to zona pellucida (GO:0007339)9.18778057
6cell-cell recognition (GO:0009988)9.01400310
7spermatid development (GO:0007286)8.50998362
8regulation of cilium movement (GO:0003352)8.32910961
9reproduction (GO:0000003)8.31747033
10piRNA metabolic process (GO:0034587)8.19322077
11male meiosis (GO:0007140)7.65140467
12single fertilization (GO:0007338)7.05112692
13synaptonemal complex organization (GO:0070193)7.03033258
14ventricular system development (GO:0021591)6.72551502
15synaptonemal complex assembly (GO:0007130)6.60118666
16sperm capacitation (GO:0048240)6.57814835
17negative regulation of inclusion body assembly (GO:0090084)6.21532796
18fertilization (GO:0009566)5.94491037
19spermatogenesis (GO:0007283)5.61207718
20male gamete generation (GO:0048232)5.58985988
21axoneme assembly (GO:0035082)5.41449636
22primary alcohol catabolic process (GO:0034310)5.34801222
23microtubule severing (GO:0051013)5.27611317
24tolerance induction (GO:0002507)5.20302851
25DNA methylation involved in gamete generation (GO:0043046)5.17160832
26gamete generation (GO:0007276)5.15855706
27microtubule depolymerization (GO:0007019)5.15618853
28calcium ion-dependent exocytosis (GO:0017156)5.12013060
29regulation of inclusion body assembly (GO:0090083)5.09193599
30male meiosis I (GO:0007141)5.05195169
31regulation of microtubule-based movement (GO:0060632)5.05071432
32protein localization to cilium (GO:0061512)5.04849901
33diterpenoid biosynthetic process (GO:0016102)4.79943149
34negative regulation of immunoglobulin mediated immune response (GO:0002890)4.78911484
35negative regulation of B cell mediated immunity (GO:0002713)4.78911484
36cellular process involved in reproduction in multicellular organism (GO:0022412)4.77984600
37germ cell development (GO:0007281)4.77680443
38cell recognition (GO:0008037)4.71915577
39organic cation transport (GO:0015695)4.66458529
40intraciliary transport (GO:0042073)4.65707480
41vitamin transmembrane transport (GO:0035461)4.64667393
42chromosome organization involved in meiosis (GO:0070192)4.46011017
43protein polyglutamylation (GO:0018095)4.36441094
44left/right pattern formation (GO:0060972)4.34205176
45positive regulation of tolerance induction (GO:0002645)4.33919257
46ethanol metabolic process (GO:0006067)4.30059590
47pyrimidine-containing compound transmembrane transport (GO:0072531)4.26347367
48meiotic nuclear division (GO:0007126)4.26080780
49nucleoside diphosphate phosphorylation (GO:0006165)4.22910573
50spermatid nucleus differentiation (GO:0007289)4.18122735
51GTP biosynthetic process (GO:0006183)4.15335606
52multicellular organismal reproductive process (GO:0048609)4.06429990
53cilium organization (GO:0044782)4.06301438
54meiosis I (GO:0007127)4.06080128
55seminiferous tubule development (GO:0072520)4.00485056
56one-carbon compound transport (GO:0019755)3.96859289
57response to xenobiotic stimulus (GO:0009410)3.93448642
58cilium assembly (GO:0042384)3.89119454
59microtubule-based movement (GO:0007018)3.85869499
60cilium morphogenesis (GO:0060271)3.85727464
61regulation of interleukin-5 production (GO:0032674)3.83158182
62establishment of planar polarity (GO:0001736)3.78545360
63establishment of tissue polarity (GO:0007164)3.78545360
64meiotic cell cycle (GO:0051321)3.77730175
65negative regulation of T cell differentiation in thymus (GO:0033085)3.75362615
66left/right axis specification (GO:0070986)3.71761681
67regulation of germinal center formation (GO:0002634)3.68366784
68UTP biosynthetic process (GO:0006228)3.63468577
69cellular component assembly involved in morphogenesis (GO:0010927)3.59759520
70glomerular epithelial cell development (GO:0072310)3.51406416
71lateral sprouting from an epithelium (GO:0060601)3.50957634
72lung epithelium development (GO:0060428)3.50854147
73apical protein localization (GO:0045176)3.49092673
74smoothened signaling pathway (GO:0007224)3.45337946
75retinal rod cell development (GO:0046548)3.44356674
76monoubiquitinated protein deubiquitination (GO:0035520)3.44200134
77glycerol ether metabolic process (GO:0006662)3.44135876
78exogenous drug catabolic process (GO:0042738)3.40572459
79cytoplasmic microtubule organization (GO:0031122)3.40100280
80regulation of tolerance induction (GO:0002643)3.33402683
81terpenoid biosynthetic process (GO:0016114)3.30462837
82determination of left/right symmetry (GO:0007368)3.29896847
83UTP metabolic process (GO:0046051)3.29093243
84chaperone-mediated protein complex assembly (GO:0051131)3.26687862
85retinoic acid metabolic process (GO:0042573)3.23215842
86negative regulation of humoral immune response (GO:0002921)3.22972421
87nonmotile primary cilium assembly (GO:0035058)3.22425107
88multicellular organismal development (GO:0007275)3.21055508
89ether metabolic process (GO:0018904)3.19874688
90ethanol oxidation (GO:0006069)3.18740715
91determination of bilateral symmetry (GO:0009855)3.15230941
92negative regulation of organelle assembly (GO:1902116)3.09327580
93regulation of interleukin-13 production (GO:0032656)3.09087189
94establishment or maintenance of monopolar cell polarity (GO:0061339)3.07456229
95establishment of monopolar cell polarity (GO:0061162)3.07456229
96specification of symmetry (GO:0009799)3.07353324
97genitalia morphogenesis (GO:0035112)3.05850402
98protein K11-linked deubiquitination (GO:0035871)3.02232477
99polyol catabolic process (GO:0046174)3.01540938
100protein refolding (GO:0042026)3.01198250
101guanosine-containing compound biosynthetic process (GO:1901070)3.00325883
102lateral ventricle development (GO:0021670)2.98649840
103establishment of apical/basal cell polarity (GO:0035089)2.98529521
104regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.97872686
105microtubule bundle formation (GO:0001578)2.95447831
106negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.88496383
107embryonic body morphogenesis (GO:0010172)2.86082204
108positive regulation of smoothened signaling pathway (GO:0045880)2.83354962
109lactate metabolic process (GO:0006089)2.81042979
110regulation of cilium assembly (GO:1902017)2.79907510
111microtubule-based process (GO:0007017)2.77445599
112regulation of centriole replication (GO:0046599)2.75872283
113neural tube formation (GO:0001841)2.74947103
114gene silencing by RNA (GO:0031047)2.74160968
115microtubule polymerization or depolymerization (GO:0031109)2.73192908
116centriole assembly (GO:0098534)2.70788181
117alditol metabolic process (GO:0019400)2.69723182
118chromosome condensation (GO:0030261)2.69415120
119meiotic cell cycle process (GO:1903046)2.68695833
120drug catabolic process (GO:0042737)2.65370649
121organelle assembly (GO:0070925)2.65284811
122glycolytic process (GO:0006096)2.64853400
123regulation of microtubule depolymerization (GO:0031114)2.63095807
124centriole replication (GO:0007099)2.61201248
125CTP metabolic process (GO:0046036)2.61048451
126CTP biosynthetic process (GO:0006241)2.61048451
127regulation of autophagic vacuole assembly (GO:2000785)2.60456838
128regulation of meiosis I (GO:0060631)2.59323299
129DNA packaging (GO:0006323)2.57335684
130asymmetric protein localization (GO:0008105)2.56762124
131synapsis (GO:0007129)2.56708546
132regulation of spindle checkpoint (GO:0090231)2.55291648
133retinol metabolic process (GO:0042572)2.53182407
134peptidyl-glutamic acid modification (GO:0018200)2.51911115
135carnitine transport (GO:0015879)2.50593134
136amino-acid betaine transport (GO:0015838)2.50593134
137positive regulation of cell size (GO:0045793)2.49094411
138regulation of collateral sprouting (GO:0048670)2.48342030
139cell projection assembly (GO:0030031)2.46826643
140glycerol metabolic process (GO:0006071)2.46586902
141carnitine transmembrane transport (GO:1902603)2.45371111
142photoreceptor cell maintenance (GO:0045494)2.44458446
143spinal cord motor neuron differentiation (GO:0021522)2.43951081
144activated T cell proliferation (GO:0050798)2.43829404
145membrane depolarization during action potential (GO:0086010)2.40872682
146negative regulation of adaptive immune response (GO:0002820)2.40866735
147phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.39810220
148regulation of smoothened signaling pathway (GO:0008589)2.39748645
149O-glycan processing (GO:0016266)2.38872742
150glutathione derivative biosynthetic process (GO:1901687)2.37514982
151glutathione derivative metabolic process (GO:1901685)2.37514982
152embryonic camera-type eye development (GO:0031076)2.34477130
153establishment of nucleus localization (GO:0040023)2.33699302
154hydrogen peroxide biosynthetic process (GO:0050665)2.33062294
155sialylation (GO:0097503)2.32844797
156polyol transport (GO:0015791)2.31478621
157retinal cone cell development (GO:0046549)2.30611046
158ear development (GO:0043583)2.29512420
159phosphatidylcholine biosynthetic process (GO:0006656)2.27504925
160cilium or flagellum-dependent cell motility (GO:0001539)13.6944466
161axonemal dynein complex assembly (GO:0070286)11.9777338
162fusion of sperm to egg plasma membrane (GO:0007342)11.9539390
163sperm motility (GO:0030317)11.5450586
164epithelial cilium movement (GO:0003351)11.1241144
165acrosome assembly (GO:0001675)10.7529525
166cilium movement (GO:0003341)10.5219935
167multicellular organism reproduction (GO:0032504)10.1330874
168sperm-egg recognition (GO:0035036)10.1142305
169cell wall macromolecule metabolic process (GO:0044036)10.0566951
170cell wall macromolecule catabolic process (GO:0016998)10.0566951

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.79748293
2EZH2_22144423_ChIP-Seq_EOC_Human5.57696925
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.73224787
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.38217336
5DROSHA_22980978_ChIP-Seq_HELA_Human2.97329710
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69574218
7FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.40148856
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.24059730
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.23366786
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.21367083
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.19256151
12GATA1_26923725_Chip-Seq_HPCs_Mouse2.07280822
13PIAS1_25552417_ChIP-Seq_VCAP_Human2.04999998
14VDR_22108803_ChIP-Seq_LS180_Human2.04843992
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.00308892
16ESR1_20079471_ChIP-ChIP_T-47D_Human1.94547418
17ZNF274_21170338_ChIP-Seq_K562_Hela1.94440945
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.93400109
19AHR_22903824_ChIP-Seq_MCF-7_Human1.92584639
20NR3C1_21868756_ChIP-Seq_MCF10A_Human1.89633713
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.83950090
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.82502086
23CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.79288951
24CTBP2_25329375_ChIP-Seq_LNCAP_Human1.78178585
25REST_21632747_ChIP-Seq_MESCs_Mouse1.77607644
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.76883207
27EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.76795828
28ARNT_22903824_ChIP-Seq_MCF-7_Human1.76429199
29KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.73815028
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.71264268
31TAF15_26573619_Chip-Seq_HEK293_Human1.70278937
32STAT6_21828071_ChIP-Seq_BEAS2B_Human1.67952027
33TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.64392488
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63704984
35CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60630447
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59863103
37RNF2_27304074_Chip-Seq_NSC_Mouse1.57211972
38ELK4_26923725_Chip-Seq_MESODERM_Mouse1.57156219
39CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.55859934
40RUNX_20019798_ChIP-Seq_JUKART_Human1.55339853
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54718338
42RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.53477975
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50092276
44MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.49528944
45TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.49511765
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49041081
47TAL1_26923725_Chip-Seq_HPCs_Mouse1.48635971
48FOXM1_26456572_ChIP-Seq_MCF-7_Human1.47694030
49TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.47342030
50PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45848355
51KDM2B_26808549_Chip-Seq_REH_Human1.44551830
52SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44218180
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43725842
54NFE2_27457419_Chip-Seq_LIVER_Mouse1.43399042
55CBP_20019798_ChIP-Seq_JUKART_Human1.42154907
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42154907
57STAT1_17558387_ChIP-Seq_HELA_Human1.40818073
58TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40695097
59POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.40695097
60BCAT_22108803_ChIP-Seq_LS180_Human1.40659108
61AR_21572438_ChIP-Seq_LNCaP_Human1.39542217
62WDR5_24793694_ChIP-Seq_LNCAP_Human1.38275287
63KAP1_22055183_ChIP-Seq_ESCs_Mouse1.38210803
64GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.35681335
65NANOG_18555785_Chip-Seq_ESCs_Mouse1.33841012
66FLI1_21867929_ChIP-Seq_TH2_Mouse1.33000612
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.32358129
68TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31501651
69EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28652152
70ETV1_20927104_ChIP-Seq_GIST48_Human1.26811954
71* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.26636834
72TP53_18474530_ChIP-ChIP_U2OS_Human1.25730867
73TP63_23658742_ChIP-Seq_EP156T_Human1.23448899
74PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.23413407
75SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22023237
76GBX2_23144817_ChIP-Seq_PC3_Human1.21756980
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.21636802
78CTNNB1_20460455_ChIP-Seq_HCT116_Human1.20263028
79STAT3_23295773_ChIP-Seq_U87_Human1.20208272
80P53_22387025_ChIP-Seq_ESCs_Mouse1.19434590
81SMAD4_21799915_ChIP-Seq_A2780_Human1.19273643
82SOX2_22085726_ChIP-Seq_NPCs_Mouse1.18331242
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17757909
84RBPJ_22232070_ChIP-Seq_NCS_Mouse1.16995227
85TRIM28_21343339_ChIP-Seq_HEK293_Human1.15613692
86SMRT_27268052_Chip-Seq_Bcells_Human1.14640466
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.13782331
88OCT4_18555785_Chip-Seq_ESCs_Mouse1.13712462
89CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13369193
90RUNX1_27514584_Chip-Seq_MCF-7_Human1.13358637
91ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12926897
92CMYC_18555785_Chip-Seq_ESCs_Mouse1.12779680
93SMC4_20622854_ChIP-Seq_HELA_Human1.12035391
94RUNX2_22187159_ChIP-Seq_PCA_Human1.11951662
95TCF4_22108803_ChIP-Seq_LS180_Human1.11949292
96CRX_20693478_ChIP-Seq_RETINA_Mouse1.11771707
97PHF8_20622853_ChIP-Seq_HELA_Human1.11086384
98EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.10867827
99P300_18555785_Chip-Seq_ESCs_Mouse1.10594220
100* GATA3_21867929_ChIP-Seq_CD8_Mouse1.10335910
101CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09655020
102LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.08263163
103GATA3_21867929_ChIP-Seq_TH1_Mouse1.08013333
104SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07682468
105FUS_26573619_Chip-Seq_HEK293_Human1.07095925
106* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06749470
107STAT3_18555785_Chip-Seq_ESCs_Mouse1.06501586
108RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05784531
109ER_23166858_ChIP-Seq_MCF-7_Human1.05445274
110GF1_26923725_Chip-Seq_HPCs_Mouse1.04906196
111TCF4_23295773_ChIP-Seq_U87_Human1.04887900
112EZH2_27294783_Chip-Seq_NPCs_Mouse1.04544235
113FOXA1_25552417_ChIP-Seq_VCAP_Human1.04204076
114CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04172082
115CBX2_22325352_ChIP-Seq_293T-Rex_Human1.03959212
116KLF4_18555785_Chip-Seq_ESCs_Mouse1.03734683
117AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02982389
118TBL1_22424771_ChIP-Seq_293T_Human1.02951766
119CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02520070
120POU3F2_20337985_ChIP-ChIP_501MEL_Human1.02185022
121FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02048099
122SMAD4_21741376_ChIP-Seq_EPCs_Human1.02028373
123CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01127161
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.00864381
125ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00488464
126SOX9_26525672_Chip-Seq_HEART_Mouse1.00164397
127PRDM14_20953172_ChIP-Seq_ESCs_Human0.99925513
128OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99888770
129SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.99836471
130TP53_16413492_ChIP-PET_HCT116_Human0.99739536
131ESRRB_18555785_Chip-Seq_ESCs_Mouse0.99724478
132* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99703227
133E2F1_18555785_Chip-Seq_ESCs_Mouse0.99496028
134HNFA_21074721_ChIP-Seq_CACO-2_Human0.98741744
135SOX2_18555785_Chip-Seq_ESCs_Mouse0.98618246
136KLF5_25053715_ChIP-Seq_YYC3_Human0.97611804
137NFYA_21822215_ChIP-Seq_K562_Human0.97248651
138RUNX1_27457419_Chip-Seq_LIVER_Mouse0.96521775
139P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96324072
140RUNX1_26923725_Chip-Seq_HPCs_Mouse0.95434345
141CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.95157382
142NFYB_21822215_ChIP-Seq_K562_Human0.94288903
143PU1_27457419_Chip-Seq_LIVER_Mouse0.93910239
144P53_21459846_ChIP-Seq_SAOS-2_Human0.93829690
145EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93815358
146SMAD3_21741376_ChIP-Seq_EPCs_Human0.93070973
147P300_19829295_ChIP-Seq_ESCs_Human0.92852293
148MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92528265
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92455660
150SMAD3_21741376_ChIP-Seq_ESCs_Human0.91979213
151SUZ12_27294783_Chip-Seq_ESCs_Mouse0.91834241
152RBPJ_21746931_ChIP-Seq_IB4_Human0.91795168
153REST_18959480_ChIP-ChIP_MESCs_Mouse0.91722582
154RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91161466
155RNF2_27304074_Chip-Seq_ESCs_Mouse0.90958891
156TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90753262
157SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90321063
158AR_25329375_ChIP-Seq_VCAP_Human0.89865749
159BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.89190726
160EWS_26573619_Chip-Seq_HEK293_Human0.88311013
161STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.87829420
162ESR2_21235772_ChIP-Seq_MCF-7_Human0.87416802
163FOXO3_23340844_ChIP-Seq_DLD1_Human0.86969441
164TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85088861
165TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.84567427

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.42822311
2MP0001929_abnormal_gametogenesis4.86980910
3MP0008875_abnormal_xenobiotic_pharmacok4.71355362
4MP0008877_abnormal_DNA_methylation4.33244999
5MP0000566_synostosis4.08433865
6MP0002653_abnormal_ependyma_morphology3.98865455
7MP0002132_abnormal_respiratory_system3.85306176
8MP0002277_abnormal_respiratory_mucosa3.71895959
9MP0004043_abnormal_pH_regulation3.55448387
10MP0008789_abnormal_olfactory_epithelium3.27327047
11MP0002210_abnormal_sex_determination3.26588717
12MP0002161_abnormal_fertility/fecundity2.97429331
13MP0001984_abnormal_olfaction2.91782974
14MP0001145_abnormal_male_reproductive2.70873412
15MP0005623_abnormal_meninges_morphology2.51594314
16MP0000383_abnormal_hair_follicle2.49355274
17MP0000653_abnormal_sex_gland2.40090695
18MP0009046_muscle_twitch2.36284163
19MP0005410_abnormal_fertilization13.5356993
20MP0002160_abnormal_reproductive_system1.82025321
21MP0010678_abnormal_skin_adnexa1.75916130
22MP0002168_other_aberrant_phenotype1.57599848
23MP0005083_abnormal_biliary_tract1.54885025
24MP0003646_muscle_fatigue1.51674923
25MP0006082_CNS_inflammation1.50662694
26MP0004019_abnormal_vitamin_homeostasis1.45585586
27MP0003880_abnormal_central_pattern1.39316383
28MP0002282_abnormal_trachea_morphology1.36011414
29MP0005645_abnormal_hypothalamus_physiol1.35845465
30MP0009780_abnormal_chondrocyte_physiolo1.33439628
31MP0003635_abnormal_synaptic_transmissio1.31824057
32MP0001346_abnormal_lacrimal_gland1.30797969
33MP0004270_analgesia1.28598655
34MP0005646_abnormal_pituitary_gland1.25398318
35MP0002736_abnormal_nociception_after1.25336090
36MP0001968_abnormal_touch/_nociception1.22930539
37MP0005670_abnormal_white_adipose1.21969805
38MP0004859_abnormal_synaptic_plasticity1.21643969
39MP0004883_abnormal_blood_vessel1.20308754
40MP0002233_abnormal_nose_morphology1.20094068
41MP0001529_abnormal_vocalization1.18005175
42MP0009745_abnormal_behavioral_response1.13769940
43MP0005551_abnormal_eye_electrophysiolog1.12589040
44MP0001440_abnormal_grooming_behavior1.11629456
45MP0002572_abnormal_emotion/affect_behav1.10780669
46MP0002102_abnormal_ear_morphology1.09366227
47MP0004233_abnormal_muscle_weight1.08128531
48MP0010030_abnormal_orbit_morphology1.07869100
49MP0003938_abnormal_ear_development1.07128653
50MP0002638_abnormal_pupillary_reflex1.06429875
51MP0009379_abnormal_foot_pigmentation1.05809732
52MP0002063_abnormal_learning/memory/cond1.05742206
53MP0003879_abnormal_hair_cell1.04884165
54MP0008995_early_reproductive_senescence1.03857018
55MP0003937_abnormal_limbs/digits/tail_de1.03529680
56MP0004742_abnormal_vestibular_system1.02205321
57MP0002064_seizures0.99771597
58MP0002272_abnormal_nervous_system0.99566000
59MP0001188_hyperpigmentation0.98244933
60MP0001486_abnormal_startle_reflex0.96892880
61MP0005248_abnormal_Harderian_gland0.96709445
62MP0005395_other_phenotype0.94470903
63MP0002734_abnormal_mechanical_nocicepti0.92076843
64MP0001765_abnormal_ion_homeostasis0.91999853
65MP0005423_abnormal_somatic_nervous0.91130449
66MP0005389_reproductive_system_phenotype0.88698169
67MP0002249_abnormal_larynx_morphology0.88310212
68MP0003329_amyloid_beta_deposits0.87044916
69MP0001293_anophthalmia0.86085129
70MP0002405_respiratory_system_inflammati0.84773308
71MP0004811_abnormal_neuron_physiology0.80335093
72MP0002557_abnormal_social/conspecific_i0.79859667
73MP0005174_abnormal_tail_pigmentation0.79524100
74MP0003136_yellow_coat_color0.79142676
75MP0004885_abnormal_endolymph0.78742263
76MP0000049_abnormal_middle_ear0.78024457
77MP0006276_abnormal_autonomic_nervous0.76694284
78MP0002067_abnormal_sensory_capabilities0.74959038
79MP0005647_abnormal_sex_gland0.74738657
80MP0003011_delayed_dark_adaptation0.73624764
81MP0000778_abnormal_nervous_system0.72841319
82MP0005377_hearing/vestibular/ear_phenot0.72245828
83MP0003878_abnormal_ear_physiology0.72245828
84MP0002152_abnormal_brain_morphology0.72168121
85MP0005253_abnormal_eye_physiology0.71831290
86MP0003045_fibrosis0.71093417
87MP0004142_abnormal_muscle_tone0.70376543
88MP0001664_abnormal_digestion0.69315527
89MP0005310_abnormal_salivary_gland0.68432738
90MP0008058_abnormal_DNA_repair0.67953537
91MP0003656_abnormal_erythrocyte_physiolo0.67410302
92MP0000465_gastrointestinal_hemorrhage0.67178161
93MP0005164_abnormal_response_to0.66877794
94MP0002735_abnormal_chemical_nociception0.66750932
95MP0002882_abnormal_neuron_morphology0.66649228
96MP0008057_abnormal_DNA_replication0.64916992
97MP0010155_abnormal_intestine_physiology0.64341827
98MP0001963_abnormal_hearing_physiology0.64137640
99MP0002116_abnormal_craniofacial_bone0.62924370
100MP0001501_abnormal_sleep_pattern0.62658963
101MP0003633_abnormal_nervous_system0.62527705
102MP0002184_abnormal_innervation0.62481753
103MP0002234_abnormal_pharynx_morphology0.61582005
104MP0004133_heterotaxia0.60872587
105MP0005409_darkened_coat_color0.60851112
106MP0003861_abnormal_nervous_system0.60582734
107MP0002229_neurodegeneration0.60194845
108MP0000955_abnormal_spinal_cord0.58979691
109MP0002752_abnormal_somatic_nervous0.58883782
110MP0003942_abnormal_urinary_system0.58495799
111MP0001485_abnormal_pinna_reflex0.57789374
112MP0001790_abnormal_immune_system0.57495646
113MP0005387_immune_system_phenotype0.57495646
114MP0008872_abnormal_physiological_respon0.56978222
115MP0006072_abnormal_retinal_apoptosis0.54064711
116MP0008569_lethality_at_weaning0.51643714
117MP0002928_abnormal_bile_duct0.50698393
118MP0003631_nervous_system_phenotype0.49851336
119MP0002066_abnormal_motor_capabilities/c0.48528426
120MP0002909_abnormal_adrenal_gland0.48481789
121MP0003787_abnormal_imprinting0.47793297
122MP0005391_vision/eye_phenotype0.46763393
123MP0001502_abnormal_circadian_rhythm0.46426894
124MP0003786_premature_aging0.45927632
125MP0003634_abnormal_glial_cell0.45445658
126MP0000026_abnormal_inner_ear0.44051551
127MP0008004_abnormal_stomach_pH0.43079487
128MP0003699_abnormal_female_reproductive0.43035433
129MP0005195_abnormal_posterior_eye0.42823754
130MP0001324_abnormal_eye_pigmentation0.42540216
131MP0000631_abnormal_neuroendocrine_gland0.42459285
132MP0003950_abnormal_plasma_membrane0.42424487
133MP0000751_myopathy0.42153061
134MP0001905_abnormal_dopamine_level0.41507202
135MP0000358_abnormal_cell_content/0.41144443
136MP0002822_catalepsy0.41144276
137MP0005636_abnormal_mineral_homeostasis0.40681140
138MP0001970_abnormal_pain_threshold0.39721282
139MP0005394_taste/olfaction_phenotype0.39376812
140MP0005499_abnormal_olfactory_system0.39376812
141MP0003115_abnormal_respiratory_system0.37833929
142MP0000569_abnormal_digit_pigmentation0.37358237
143MP0001986_abnormal_taste_sensitivity0.35893651
144MP0004145_abnormal_muscle_electrophysio0.35830093
145MP0002733_abnormal_thermal_nociception0.33831049

Predicted human phenotypes

RankGene SetZ-score
1* Abnormal respiratory motile cilium physiology (HP:0012261)9.64743745
2Abnormal respiratory motile cilium morphology (HP:0005938)9.17186886
3Abnormal respiratory epithelium morphology (HP:0012253)9.17186886
4Abnormal ciliary motility (HP:0012262)8.76016905
5* Rhinitis (HP:0012384)7.69505676
6* Chronic bronchitis (HP:0004469)6.31496257
7Nasal polyposis (HP:0100582)5.91486481
8Infertility (HP:0000789)5.65731828
9Abnormality of the nasal mucosa (HP:0000433)4.80704550
10Nephronophthisis (HP:0000090)4.54420063
11* Bronchiectasis (HP:0002110)4.45523571
12* Bronchitis (HP:0012387)3.63476288
13Abnormality of the renal medulla (HP:0100957)3.50929733
14Recurrent sinusitis (HP:0011108)3.45343318
15Molar tooth sign on MRI (HP:0002419)3.21766113
16Abnormality of midbrain morphology (HP:0002418)3.21766113
17Medial flaring of the eyebrow (HP:0010747)3.17549130
18Tubulointerstitial nephritis (HP:0001970)3.16552936
19Male infertility (HP:0003251)3.11175929
20Chronic otitis media (HP:0000389)2.97671060
21Hyperactive renin-angiotensin system (HP:0000841)2.83201331
22* Recurrent otitis media (HP:0000403)2.74006171
23Atelectasis (HP:0100750)2.71972816
24Pancreatic fibrosis (HP:0100732)2.64407688
25Tubular atrophy (HP:0000092)2.63216736
26Tubulointerstitial abnormality (HP:0001969)2.53982689
27Postaxial foot polydactyly (HP:0001830)2.47166479
28Abnormal spermatogenesis (HP:0008669)2.43939722
29Abnormality of dentin (HP:0010299)2.39172509
30Gait imbalance (HP:0002141)2.32599320
31Abnormality of the lower motor neuron (HP:0002366)2.26635032
32Congenital primary aphakia (HP:0007707)2.25280894
33True hermaphroditism (HP:0010459)2.24506188
34Fibular hypoplasia (HP:0003038)2.20615109
35Congenital hepatic fibrosis (HP:0002612)2.17124676
36Stage 5 chronic kidney disease (HP:0003774)2.04351818
37Recurrent bronchitis (HP:0002837)2.02664307
38Aplasia/Hypoplasia of the tongue (HP:0010295)2.01236155
39Gonadotropin excess (HP:0000837)2.00663506
40Postaxial hand polydactyly (HP:0001162)2.00533166
41* Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1796352
42Dynein arm defect of respiratory motile cilia (HP:0012255)12.2597491
43Absent/shortened dynein arms (HP:0200106)12.2597491
44Cystic liver disease (HP:0006706)1.99636658
45Oculomotor apraxia (HP:0000657)1.96693973
46Nephrogenic diabetes insipidus (HP:0009806)1.96544581
47Tubulointerstitial fibrosis (HP:0005576)1.94591106
48Chronic sinusitis (HP:0011109)1.93127070
49Median cleft lip (HP:0000161)1.92166736
50Abnormality of the dental root (HP:0006486)1.88291878
51Taurodontia (HP:0000679)1.88291878
52Abnormality of permanent molar morphology (HP:0011071)1.88291878
53Polydipsia (HP:0001959)1.87042495
54Abnormal drinking behavior (HP:0030082)1.87042495
55Amyotrophic lateral sclerosis (HP:0007354)1.86316304
56Abnormality of the dental pulp (HP:0006479)1.86040486
57Abnormality of the renal cortex (HP:0011035)1.85788487
58Microglossia (HP:0000171)1.84886238
59Renal salt wasting (HP:0000127)1.84345833
60Chronic hepatic failure (HP:0100626)1.80882961
61Azoospermia (HP:0000027)1.80207520
62Supernumerary spleens (HP:0009799)1.79890005
63Impulsivity (HP:0100710)1.78676880
64Genital tract atresia (HP:0001827)1.78189044
65Pancreatic cysts (HP:0001737)1.78123591
66Abnormality of molar (HP:0011077)1.77589488
67Abnormality of molar morphology (HP:0011070)1.77589488
68Abnormal biliary tract physiology (HP:0012439)1.74741233
69Bile duct proliferation (HP:0001408)1.74741233
70Poor coordination (HP:0002370)1.71504663
71Bell-shaped thorax (HP:0001591)1.70422150
72Aplasia/Hypoplasia of the lens (HP:0008063)1.70226506
73Vaginal atresia (HP:0000148)1.68512471
74Asplenia (HP:0001746)1.68146478
75Facial cleft (HP:0002006)1.68081497
76Furrowed tongue (HP:0000221)1.66512578
77Decreased central vision (HP:0007663)1.65969483
78Decreased circulating renin level (HP:0003351)1.64069334
79Recurrent gram-negative bacterial infections (HP:0005420)1.63042551
80Short ribs (HP:0000773)1.62996939
81Aplasia/Hypoplasia of the spleen (HP:0010451)1.61979271
82Absent rod-and cone-mediated responses on ERG (HP:0007688)1.61047814
83Abnormality of renal excretion (HP:0011036)1.54422835
84Occipital encephalocele (HP:0002085)1.54339025
85Renal dysplasia (HP:0000110)1.53072631
86Dyschromatopsia (HP:0007641)1.48918537
87Retinal dysplasia (HP:0007973)1.48889760
88Hyperaldosteronism (HP:0000859)1.47751593
89Nephropathy (HP:0000112)1.47314296
90Abnormal gallbladder physiology (HP:0012438)1.47006561
91Cholecystitis (HP:0001082)1.47006561
92Broad distal phalanx of finger (HP:0009836)1.45446282
93Choroideremia (HP:0001139)1.44583920
94Hypoplasia of the capital femoral epiphysis (HP:0003090)1.44500419
95Aplasia/Hypoplasia of the fibula (HP:0006492)1.44299218
96Short thorax (HP:0010306)1.33653033
97Abnormality of renin-angiotensin system (HP:0000847)1.33608711
98Lip pit (HP:0100267)1.33492887
99Absent frontal sinuses (HP:0002688)1.32039542
100J-shaped sella turcica (HP:0002680)1.31257207
101Hyponatremia (HP:0002902)1.30739782
102Abnormal urine output (HP:0012590)1.30372826
103Anencephaly (HP:0002323)1.29847325
104Sclerocornea (HP:0000647)1.29096781
105Abnormality of ocular smooth pursuit (HP:0000617)1.27629132
106Hypokalemic alkalosis (HP:0001949)1.27275453
107Impaired proprioception (HP:0010831)1.26166728
108Spastic tetraparesis (HP:0001285)1.25610956
109Polyuria (HP:0000103)1.25425737
110Gaze-evoked nystagmus (HP:0000640)1.25346768
111Preaxial hand polydactyly (HP:0001177)1.25163769
112Abnormality of chloride homeostasis (HP:0011422)1.23117824
113Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.22899420
114Progressive cerebellar ataxia (HP:0002073)1.22017663
115Aplasia of the musculature (HP:0100854)1.21185945
116Male pseudohermaphroditism (HP:0000037)1.19695747
117Heterotopia (HP:0002282)1.19453505
118Retinitis pigmentosa (HP:0000510)1.19297121
119Hyperkalemia (HP:0002153)1.17573875
120Abnormality of macular pigmentation (HP:0008002)1.16457467
121Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.11797614
122Narrow forehead (HP:0000341)1.10487181
123Cone-rod dystrophy (HP:0000548)1.10121662
124Autoimmune thrombocytopenia (HP:0001973)1.10076720
125Bifid scrotum (HP:0000048)1.09565090
126Multicystic kidney dysplasia (HP:0000003)1.02891998
127Abnormality of the frontal sinuses (HP:0002687)1.01594865
128Highly arched eyebrow (HP:0002553)1.01476106
129Short nail (HP:0001799)1.00988965
130Fetal akinesia sequence (HP:0001989)1.00935426
131Short femoral neck (HP:0100864)1.00753558
132Abnormal rod and cone electroretinograms (HP:0008323)1.00586069

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.44226116
2PDK38.44226116
3PDK25.42100941
4TESK14.17827897
5PRKD33.70728043
6MST43.66717179
7PNCK3.58085371
8STK243.16596852
9ICK2.99330062
10EPHA22.53986884
11PTK2B2.35582971
12MAP3K22.35355632
13STK392.27958727
14MAPK152.23683650
15WNK42.22435765
16MAP3K32.01030711
17BCR1.96930992
18CSK1.82218385
19STK381.46778500
20EPHA31.33361395
21PBK1.31504840
22CASK1.29759400
23PRKCH1.19237716
24TNIK1.14800620
25MAP3K41.13054502
26TAOK31.12018910
27CCNB11.11907757
28PRKCQ1.09369745
29NEK21.06988468
30TLK11.05226027
31EPHB11.01664081
32MAP2K71.00361390
33GRK60.98818013
34FES0.97724487
35WNK10.95813790
36NTRK20.95432933
37NME10.94712501
38PDK10.94541026
39TAOK10.94164848
40YES10.90598568
41TYRO30.87184963
42LMTK20.84818098
43MARK10.82769287
44DYRK1B0.80840740
45DYRK30.79938453
46ERBB20.72809725
47PRKCG0.71043300
48WEE10.70754258
49TXK0.69908319
50LRRK20.67274786
51MAP3K70.67166498
52NLK0.64207219
53PINK10.63010700
54DAPK20.59679385
55TRPM70.59204361
56IRAK10.57365592
57STK100.56542541
58PRKCI0.56530130
59NTRK30.56122350
60ADRBK10.56118187
61MUSK0.53841312
62SGK20.53514951
63EEF2K0.53211693
64EPHA40.52194714
65BMPR1B0.50823727
66DYRK20.49788653
67STK30.49539989
68MINK10.48246297
69PAK30.47553144
70MAPKAPK50.46035151
71STK38L0.45565937
72FYN0.45218102
73PDPK10.45041553
74MAP2K40.44097516
75SGK10.43812526
76UHMK10.43179726
77PRKCD0.42474780
78PAK60.42412111
79CAMKK10.39546345
80PLK20.39528360
81CAMK1G0.38916511
82CHEK20.38747648
83RIPK40.37043412
84EGFR0.36845068
85CAMK2A0.36555727
86HCK0.34861496
87CDK30.34301007
88TTK0.34219064
89MAPK130.34006880
90TRIM280.33720893
91BRSK20.33396938
92MARK20.33351715
93MAP3K90.33257716
94FGR0.32394716
95LCK0.31750489
96FGFR20.31152877
97OXSR10.30995898
98ABL10.30822289
99WNK30.28753091
100FRK0.28699718
101CHEK10.28678483
102CDC70.28245023
103PASK0.27831862
104NEK60.27798122
105BRAF0.27291389
106RET0.26669360
107GRK10.25897710
108GRK50.25538923
109PRKCA0.25320387
110CAMKK20.25243331
111TEC0.25176556
112PDGFRB0.25032843
113MAP4K10.24878072
114STK110.23865786
115PAK10.23851864
116MAP2K60.23649835
117AKT30.23554454
118CAMK40.23508783
119CAMK2G0.22937038
120JAK30.22447626
121PHKG10.22436238
122PHKG20.22436238
123DAPK10.22218763
124PLK40.22049759
125CDK50.21830537
126CDK150.21180553
127CDK180.20320244
128ATM0.19667666
129PRKAA10.18710121
130CDK11A0.16557451
131CDK140.16159359
132RPS6KB10.15835712
133PRKG10.15293529
134PRKCZ0.15145892
135PAK20.14911544
136MAPKAPK30.13901234
137AURKA0.13167972
138IRAK20.12106095
139ERBB30.11089234
140ATR0.10704228
141CAMK2B0.10243033
142STK160.09649827
143RPS6KA20.09305281
144SGK2230.08847182
145SGK4940.08847182
146PLK10.08688107
147PRKACA0.07746172
148BRSK10.07355306
149GSK3B0.06674358
150CDK190.06012102
151DYRK1A0.05987730
152PRKACB0.05562980
153MTOR0.05393104
154PRKACG0.05033118

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.16400121
2Chemical carcinogenesis_Homo sapiens_hsa052043.71224113
3Phenylalanine metabolism_Homo sapiens_hsa003603.40653266
4Pyruvate metabolism_Homo sapiens_hsa006203.38703359
5Histidine metabolism_Homo sapiens_hsa003403.13720616
6Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.10522706
7Tyrosine metabolism_Homo sapiens_hsa003502.67007966
8Fatty acid biosynthesis_Homo sapiens_hsa000612.64369412
9Amphetamine addiction_Homo sapiens_hsa050312.51850426
10Glucagon signaling pathway_Homo sapiens_hsa049222.49079071
11Olfactory transduction_Homo sapiens_hsa047402.47891346
12Huntingtons disease_Homo sapiens_hsa050162.25721781
13Synaptic vesicle cycle_Homo sapiens_hsa047212.17190549
14Dorso-ventral axis formation_Homo sapiens_hsa043202.05007541
15Basal transcription factors_Homo sapiens_hsa030222.01534217
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.00450967
17Propanoate metabolism_Homo sapiens_hsa006401.99331058
18Linoleic acid metabolism_Homo sapiens_hsa005911.95783131
19Collecting duct acid secretion_Homo sapiens_hsa049661.95616541
20Oocyte meiosis_Homo sapiens_hsa041141.94599131
21beta-Alanine metabolism_Homo sapiens_hsa004101.82419784
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.79555028
23Nicotine addiction_Homo sapiens_hsa050331.78766562
24ABC transporters_Homo sapiens_hsa020101.77048283
25Renin secretion_Homo sapiens_hsa049241.73951086
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.72274289
27Long-term potentiation_Homo sapiens_hsa047201.69428876
28Retinol metabolism_Homo sapiens_hsa008301.62972667
29Cardiac muscle contraction_Homo sapiens_hsa042601.61257319
30Phototransduction_Homo sapiens_hsa047441.52362476
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51717131
32Taste transduction_Homo sapiens_hsa047421.47710278
33Pentose phosphate pathway_Homo sapiens_hsa000301.45885389
34Circadian entrainment_Homo sapiens_hsa047131.44873109
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.44157987
36Glycerolipid metabolism_Homo sapiens_hsa005611.42825007
37Caffeine metabolism_Homo sapiens_hsa002321.42465861
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.42199695
39Fanconi anemia pathway_Homo sapiens_hsa034601.40766147
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.39671256
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.38690821
42Insulin secretion_Homo sapiens_hsa049111.37957911
43Glycerophospholipid metabolism_Homo sapiens_hsa005641.32950000
44Carbohydrate digestion and absorption_Homo sapiens_hsa049731.31498322
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.23889942
46Glutamatergic synapse_Homo sapiens_hsa047241.22042222
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.21667674
48Ether lipid metabolism_Homo sapiens_hsa005651.20598334
49Gastric acid secretion_Homo sapiens_hsa049711.20278862
50Calcium signaling pathway_Homo sapiens_hsa040201.16843528
51Salivary secretion_Homo sapiens_hsa049701.16023115
52Estrogen signaling pathway_Homo sapiens_hsa049151.15494168
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.15459066
54Morphine addiction_Homo sapiens_hsa050321.13823865
55Dopaminergic synapse_Homo sapiens_hsa047281.09525174
56PPAR signaling pathway_Homo sapiens_hsa033201.02541306
57Cysteine and methionine metabolism_Homo sapiens_hsa002701.00488738
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99222465
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.98533387
60Mineral absorption_Homo sapiens_hsa049780.98388714
61Purine metabolism_Homo sapiens_hsa002300.98385060
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95447712
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95375279
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.95327921
65Cocaine addiction_Homo sapiens_hsa050300.94586449
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93827841
67Tight junction_Homo sapiens_hsa045300.90167229
68Circadian rhythm_Homo sapiens_hsa047100.88939642
69Hematopoietic cell lineage_Homo sapiens_hsa046400.88342850
70cAMP signaling pathway_Homo sapiens_hsa040240.84594556
71Selenocompound metabolism_Homo sapiens_hsa004500.84260452
72Glycosaminoglycan degradation_Homo sapiens_hsa005310.83711059
73Basal cell carcinoma_Homo sapiens_hsa052170.83137462
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82243858
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81244747
76Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.81004133
77Carbon metabolism_Homo sapiens_hsa012000.80572394
78Fructose and mannose metabolism_Homo sapiens_hsa000510.80074192
79Oxidative phosphorylation_Homo sapiens_hsa001900.78910438
80Malaria_Homo sapiens_hsa051440.77348976
81mRNA surveillance pathway_Homo sapiens_hsa030150.76781807
82Hedgehog signaling pathway_Homo sapiens_hsa043400.76772336
83Thyroid hormone synthesis_Homo sapiens_hsa049180.75653313
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.74485234
85Primary immunodeficiency_Homo sapiens_hsa053400.74306403
86GABAergic synapse_Homo sapiens_hsa047270.73947779
87Vibrio cholerae infection_Homo sapiens_hsa051100.73901636
88Aldosterone synthesis and secretion_Homo sapiens_hsa049250.73750874
89Choline metabolism in cancer_Homo sapiens_hsa052310.73220742
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72372853
91Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72228444
92Oxytocin signaling pathway_Homo sapiens_hsa049210.71137664
93Nitrogen metabolism_Homo sapiens_hsa009100.70047081
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.67780586
95Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.66659115
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66398652
97Legionellosis_Homo sapiens_hsa051340.65836053
98T cell receptor signaling pathway_Homo sapiens_hsa046600.64491308
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63820052
100Notch signaling pathway_Homo sapiens_hsa043300.63755710
101Alzheimers disease_Homo sapiens_hsa050100.63512165
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63158366
103Graft-versus-host disease_Homo sapiens_hsa053320.61526449
104Hippo signaling pathway_Homo sapiens_hsa043900.61350737
105Peroxisome_Homo sapiens_hsa041460.60947073
106Phagosome_Homo sapiens_hsa041450.59155745
107Melanogenesis_Homo sapiens_hsa049160.57186515
108Amoebiasis_Homo sapiens_hsa051460.56412018
109Type I diabetes mellitus_Homo sapiens_hsa049400.55593192
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55138764
111Pancreatic secretion_Homo sapiens_hsa049720.54322052
112Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53627566
113Inositol phosphate metabolism_Homo sapiens_hsa005620.53383996
114Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53267714
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52305919
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52280214
117Autoimmune thyroid disease_Homo sapiens_hsa053200.51387516
118Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47509261
119Alcoholism_Homo sapiens_hsa050340.46805962
120Jak-STAT signaling pathway_Homo sapiens_hsa046300.46753301
121Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45945390
122Adherens junction_Homo sapiens_hsa045200.45897520
123Cholinergic synapse_Homo sapiens_hsa047250.44898482
124Fat digestion and absorption_Homo sapiens_hsa049750.44710639
125Parkinsons disease_Homo sapiens_hsa050120.44683796
126Wnt signaling pathway_Homo sapiens_hsa043100.43999406
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.43277997
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.42527572
129Arachidonic acid metabolism_Homo sapiens_hsa005900.42144419
130Sphingolipid signaling pathway_Homo sapiens_hsa040710.41982278
131Sphingolipid metabolism_Homo sapiens_hsa006000.41636860
132Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.40380802
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40264545
134RNA transport_Homo sapiens_hsa030130.40012634
135Endocytosis_Homo sapiens_hsa041440.39517447
136Biosynthesis of amino acids_Homo sapiens_hsa012300.39183051
137Serotonergic synapse_Homo sapiens_hsa047260.38977246
138Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38190699
139Rheumatoid arthritis_Homo sapiens_hsa053230.37996982
140Staphylococcus aureus infection_Homo sapiens_hsa051500.37624724
141Antigen processing and presentation_Homo sapiens_hsa046120.37531341
142Allograft rejection_Homo sapiens_hsa053300.37385931
143Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37207186
144Ovarian steroidogenesis_Homo sapiens_hsa049130.36292045
145AMPK signaling pathway_Homo sapiens_hsa041520.35824178
146Pertussis_Homo sapiens_hsa051330.35023947
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.34392727
148Measles_Homo sapiens_hsa051620.34390278
149Starch and sucrose metabolism_Homo sapiens_hsa005000.33667999
150Complement and coagulation cascades_Homo sapiens_hsa046100.33123913
151Hepatitis C_Homo sapiens_hsa051600.33038049
152Drug metabolism - other enzymes_Homo sapiens_hsa009830.32903923
153Axon guidance_Homo sapiens_hsa043600.32566919
154Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.32153501
155Renin-angiotensin system_Homo sapiens_hsa046140.31709945
156Bile secretion_Homo sapiens_hsa049760.31379972
157Glutathione metabolism_Homo sapiens_hsa004800.29037663
158Central carbon metabolism in cancer_Homo sapiens_hsa052300.28929254

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