CCDC58P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1otic vesicle formation (GO:0030916)8.48888547
2cytoplasmic mRNA processing body assembly (GO:0033962)5.72383320
3regulation of branching involved in salivary gland morphogenesis (GO:0060693)5.61298778
4limb bud formation (GO:0060174)5.52080109
5presynaptic membrane assembly (GO:0097105)5.50000193
6neurofilament cytoskeleton organization (GO:0060052)5.29260330
7regulation of NFAT protein import into nucleus (GO:0051532)5.26271808
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.77320931
9negative regulation of dendrite development (GO:2000171)4.70053416
10thalamus development (GO:0021794)4.67804323
11protein localization to microtubule (GO:0035372)4.54134952
12presynaptic membrane organization (GO:0097090)4.39144199
13mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)4.16818615
14positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021104.16818615
15negative regulation of glycogen biosynthetic process (GO:0045719)4.09674434
16response to auditory stimulus (GO:0010996)4.08377608
17ER overload response (GO:0006983)4.05311880
18pyrimidine-containing compound transmembrane transport (GO:0072531)4.02875190
19negative regulation of dendrite morphogenesis (GO:0050774)3.99553338
20ATP synthesis coupled proton transport (GO:0015986)3.94881010
21energy coupled proton transport, down electrochemical gradient (GO:0015985)3.94881010
22neuromuscular process controlling posture (GO:0050884)3.92470048
23regulation of meiosis I (GO:0060631)3.86967078
24neuron cell-cell adhesion (GO:0007158)3.85205245
25regulation of glycogen (starch) synthase activity (GO:2000465)3.80118171
26sequestering of actin monomers (GO:0042989)3.79210240
27positive regulation of gluconeogenesis (GO:0045722)3.75567409
28type B pancreatic cell proliferation (GO:0044342)3.65034493
29positive regulation of action potential (GO:0045760)3.59717453
30lens fiber cell development (GO:0070307)3.55689832
31vocalization behavior (GO:0071625)3.54047039
32ribosomal small subunit assembly (GO:0000028)3.53294551
33protein complex biogenesis (GO:0070271)3.48060353
34negative regulation of cardiac muscle hypertrophy (GO:0010614)3.47001917
35lung-associated mesenchyme development (GO:0060484)3.46370537
36prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.45916643
37response to insecticide (GO:0017085)3.42079865
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.37065796
39NADH dehydrogenase complex assembly (GO:0010257)3.37065796
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.37065796
41DNA deamination (GO:0045006)3.36350842
42dopamine biosynthetic process (GO:0042416)3.36271881
43CENP-A containing nucleosome assembly (GO:0034080)3.33454285
44protein localization to kinetochore (GO:0034501)3.32181020
45lateral sprouting from an epithelium (GO:0060601)3.32127756
46inner mitochondrial membrane organization (GO:0007007)3.31366000
47positive regulation of protein export from nucleus (GO:0046827)3.26018605
48establishment of protein localization to mitochondrial membrane (GO:0090151)3.23125876
49forebrain neuron development (GO:0021884)3.18829258
50negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.17966013
51negative regulation of glycogen metabolic process (GO:0070874)3.13888804
52negative regulation of muscle hypertrophy (GO:0014741)3.12124483
53histone exchange (GO:0043486)3.09131299
54organ growth (GO:0035265)3.07932635
55nucleotide transmembrane transport (GO:1901679)3.07068908
56electron transport chain (GO:0022900)3.06999920
57mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.06254232
58exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.03046883
59regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.01184367
60respiratory electron transport chain (GO:0022904)3.00274864
61chromatin remodeling at centromere (GO:0031055)2.99438603
62mitochondrial respiratory chain complex assembly (GO:0033108)2.98843403
63branching involved in labyrinthine layer morphogenesis (GO:0060670)2.97527030
64regulation of DNA methylation (GO:0044030)2.94858810
65genitalia morphogenesis (GO:0035112)2.94755232
66epithelial structure maintenance (GO:0010669)2.93679526
67primitive streak formation (GO:0090009)2.92457291
68regulation of cell maturation (GO:1903429)2.90151014
69transmission of nerve impulse (GO:0019226)2.89371627
70platelet dense granule organization (GO:0060155)2.89187001
71branch elongation of an epithelium (GO:0060602)2.88057060
72RNA destabilization (GO:0050779)2.83748983
73nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.81490583
74replication fork processing (GO:0031297)2.81238473
75stem cell division (GO:0017145)2.79723618
76embryonic digestive tract morphogenesis (GO:0048557)2.77928203
77cartilage morphogenesis (GO:0060536)2.74915941
78retina layer formation (GO:0010842)2.73260431
79negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.73050414
80DNA integration (GO:0015074)2.72694110
81cell-cell signaling involved in cell fate commitment (GO:0045168)2.72411974
82regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.71891676
83somite rostral/caudal axis specification (GO:0032525)2.70873078
84synapsis (GO:0007129)2.68369464
85signal peptide processing (GO:0006465)2.67985164
86generation of neurons (GO:0048699)2.67751260
87negative regulation of Rho protein signal transduction (GO:0035024)2.66956691
88resolution of meiotic recombination intermediates (GO:0000712)2.63602063
89axon ensheathment in central nervous system (GO:0032291)2.62497841
90central nervous system myelination (GO:0022010)2.62497841
91positive regulation of meiosis (GO:0045836)2.62492932
92digestive tract morphogenesis (GO:0048546)2.61035816
93midbrain development (GO:0030901)2.60724468
94microtubule polymerization or depolymerization (GO:0031109)2.60284619
95cranial suture morphogenesis (GO:0060363)2.59486420
96developmental induction (GO:0031128)2.58849390
97positive regulation of amino acid transport (GO:0051957)2.58024538
98mesenchymal cell proliferation (GO:0010463)2.52310919
99white fat cell differentiation (GO:0050872)2.50957295
100somatic stem cell maintenance (GO:0035019)2.49852147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.10139053
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.16087099
3MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.92723020
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.33083935
5GBX2_23144817_ChIP-Seq_PC3_Human2.95125472
6FUS_26573619_Chip-Seq_HEK293_Human2.91241598
7POU3F2_20337985_ChIP-ChIP_501MEL_Human2.80562510
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.55278539
9BMI1_23680149_ChIP-Seq_NPCS_Mouse2.47819898
10NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.42932389
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.39069398
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34217905
13P300_19829295_ChIP-Seq_ESCs_Human2.16581363
14CTBP2_25329375_ChIP-Seq_LNCAP_Human2.14198514
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.08182494
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.04060758
17RNF2_27304074_Chip-Seq_NSC_Mouse2.03104979
18POU5F1_16153702_ChIP-ChIP_HESCs_Human1.99318255
19E2F4_17652178_ChIP-ChIP_JURKAT_Human1.87446414
20FLI1_27457419_Chip-Seq_LIVER_Mouse1.85703333
21RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83915692
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.82722877
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.82521267
24SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.78794370
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.75415473
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.70683479
27EWS_26573619_Chip-Seq_HEK293_Human1.70459455
28SMAD3_21741376_ChIP-Seq_EPCs_Human1.67852884
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.67744863
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.67630833
31ZNF274_21170338_ChIP-Seq_K562_Hela1.66543553
32UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63177493
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.62949836
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.62442027
35JUN_21703547_ChIP-Seq_K562_Human1.62292017
36TOP2B_26459242_ChIP-Seq_MCF-7_Human1.60670247
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60609766
38CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.60411062
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52981919
40SOX2_16153702_ChIP-ChIP_HESCs_Human1.52631134
41MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52216712
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50689012
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.49629149
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49227312
45VDR_22108803_ChIP-Seq_LS180_Human1.48463300
46EST1_17652178_ChIP-ChIP_JURKAT_Human1.48279330
47GABP_17652178_ChIP-ChIP_JURKAT_Human1.48253008
48RNF2_27304074_Chip-Seq_ESCs_Mouse1.45429121
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.45163810
50AR_21572438_ChIP-Seq_LNCaP_Human1.45063852
51IGF1R_20145208_ChIP-Seq_DFB_Human1.43503350
52HTT_18923047_ChIP-ChIP_STHdh_Human1.42809562
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.42634114
54JARID2_20064375_ChIP-Seq_MESCs_Mouse1.41784380
55TCF4_18268006_ChIP-ChIP_LS174T_Human1.41599820
56TAF15_26573619_Chip-Seq_HEK293_Human1.41303581
57SMAD4_21799915_ChIP-Seq_A2780_Human1.40763444
58ELK1_19687146_ChIP-ChIP_HELA_Human1.40625635
59FOXM1_23109430_ChIP-Seq_U2OS_Human1.38563224
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.36600666
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34275505
62GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31612186
63RUNX2_22187159_ChIP-Seq_PCA_Human1.31368502
64EZH2_27294783_Chip-Seq_NPCs_Mouse1.30686196
65RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.30145180
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.28963665
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.28677491
68AR_25329375_ChIP-Seq_VCAP_Human1.28577270
69ER_23166858_ChIP-Seq_MCF-7_Human1.26191949
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21927994
71EZH2_27304074_Chip-Seq_ESCs_Mouse1.21482960
72ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.20377100
73NANOG_16153702_ChIP-ChIP_HESCs_Human1.18270235
74GATA1_26923725_Chip-Seq_HPCs_Mouse1.17588264
75JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16600080
76NANOG_19829295_ChIP-Seq_ESCs_Human1.14596478
77SOX2_19829295_ChIP-Seq_ESCs_Human1.14596478
78OCT4_21477851_ChIP-Seq_ESCs_Mouse1.13972023
79POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13455861
80TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13455861
81TP53_22573176_ChIP-Seq_HFKS_Human1.12567287
82BCAT_22108803_ChIP-Seq_LS180_Human1.09560545
83RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08833564
84TAL1_26923725_Chip-Seq_HPCs_Mouse1.08391130
85IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07820865
86CBP_20019798_ChIP-Seq_JUKART_Human1.07820865
87SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.04680915
88RNF2_18974828_ChIP-Seq_MESCs_Mouse1.03895540
89EZH2_18974828_ChIP-Seq_MESCs_Mouse1.03895540
90CREB1_15753290_ChIP-ChIP_HEK293T_Human1.03391854
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.03362188
92NANOG_18555785_Chip-Seq_ESCs_Mouse1.02498639
93SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01424486
94TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00428358
95RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98905287
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98724472
97CRX_20693478_ChIP-Seq_RETINA_Mouse0.98698356
98NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.98390521
99PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98162198
100NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97887289

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis8.45105585
2MP0006292_abnormal_olfactory_placode5.79156487
3MP0000569_abnormal_digit_pigmentation4.33219408
4MP0003136_yellow_coat_color3.66866552
5MP0001529_abnormal_vocalization2.65193166
6MP0002277_abnormal_respiratory_mucosa2.63617871
7MP0002282_abnormal_trachea_morphology2.32841140
8MP0003122_maternal_imprinting2.23735933
9MP0003121_genomic_imprinting2.07763601
10MP0002938_white_spotting2.06925791
11MP0000537_abnormal_urethra_morphology2.01972933
12MP0001293_anophthalmia1.97000660
13MP0005408_hypopigmentation1.94448313
14MP0005423_abnormal_somatic_nervous1.92703978
15MP0003938_abnormal_ear_development1.90660098
16MP0000631_abnormal_neuroendocrine_gland1.86413112
17MP0005075_abnormal_melanosome_morpholog1.86005381
18MP0000383_abnormal_hair_follicle1.79183136
19MP0001346_abnormal_lacrimal_gland1.77438441
20MP0002735_abnormal_chemical_nociception1.73503469
21MP0002095_abnormal_skin_pigmentation1.71225083
22MP0001299_abnormal_eye_distance/1.59026023
23MP0003890_abnormal_embryonic-extraembry1.54867291
24MP0009379_abnormal_foot_pigmentation1.53401729
25MP0004885_abnormal_endolymph1.53340295
26MP0000778_abnormal_nervous_system1.52756813
27MP0000049_abnormal_middle_ear1.51838748
28MP0010030_abnormal_orbit_morphology1.48333084
29MP0004142_abnormal_muscle_tone1.47603212
30MP0000371_diluted_coat_color1.44929285
31MP0003755_abnormal_palate_morphology1.39578249
32MP0001485_abnormal_pinna_reflex1.38057676
33MP0009250_abnormal_appendicular_skeleto1.37170686
34MP0005386_behavior/neurological_phenoty1.34338045
35MP0004924_abnormal_behavior1.34338045
36MP0000579_abnormal_nail_morphology1.32267476
37MP0001905_abnormal_dopamine_level1.32186427
38MP0002102_abnormal_ear_morphology1.27642177
39MP0001984_abnormal_olfaction1.23576475
40MP0005171_absent_coat_pigmentation1.20760221
41MP0003880_abnormal_central_pattern1.18892681
42MP0005377_hearing/vestibular/ear_phenot1.18781207
43MP0003878_abnormal_ear_physiology1.18781207
44MP0006054_spinal_hemorrhage1.17064624
45MP0000026_abnormal_inner_ear1.16523485
46MP0000372_irregular_coat_pigmentation1.15023641
47MP0003937_abnormal_limbs/digits/tail_de1.08891042
48MP0001286_abnormal_eye_development1.07836685
49MP0005174_abnormal_tail_pigmentation1.07533915
50MP0002249_abnormal_larynx_morphology1.04360048
51MP0000955_abnormal_spinal_cord0.98758163
52MP0010678_abnormal_skin_adnexa0.98598670
53MP0002075_abnormal_coat/hair_pigmentati0.97821134
54MP0001324_abnormal_eye_pigmentation0.95979645
55MP0002098_abnormal_vibrissa_morphology0.92766611
56MP0005670_abnormal_white_adipose0.92619109
57MP0003221_abnormal_cardiomyocyte_apopto0.91312155
58MP0001186_pigmentation_phenotype0.90963539
59MP0001963_abnormal_hearing_physiology0.89582270
60MP0004742_abnormal_vestibular_system0.87791540
61MP0006082_CNS_inflammation0.87273091
62MP0003935_abnormal_craniofacial_develop0.84903262
63MP0004510_myositis0.84840358
64MP0002572_abnormal_emotion/affect_behav0.84062068
65MP0004270_analgesia0.83519203
66MP0003635_abnormal_synaptic_transmissio0.82462718
67MP0000428_abnormal_craniofacial_morphol0.82444012
68MP0002233_abnormal_nose_morphology0.81459635
69MP0001851_eye_inflammation0.81331952
70MP0004134_abnormal_chest_morphology0.77114266
71MP0005084_abnormal_gallbladder_morpholo0.74289664
72MP0002090_abnormal_vision0.73659076
73MP0002752_abnormal_somatic_nervous0.73631499
74MP0002184_abnormal_innervation0.72011805
75MP0000462_abnormal_digestive_system0.70863451
76MP0002272_abnormal_nervous_system0.70840710
77MP0009046_muscle_twitch0.67965123
78MP0002089_abnormal_postnatal_growth/wei0.67539925
79MP0006276_abnormal_autonomic_nervous0.66666937
80MP0003698_abnormal_male_reproductive0.65213707
81MP0005197_abnormal_uvea_morphology0.65110609
82MP0002557_abnormal_social/conspecific_i0.64696060
83MP0006072_abnormal_retinal_apoptosis0.60976059
84MP0001486_abnormal_startle_reflex0.58781337
85MP0000647_abnormal_sebaceous_gland0.57499139
86MP0002210_abnormal_sex_determination0.56594963
87MP0000762_abnormal_tongue_morphology0.56380565
88MP0002736_abnormal_nociception_after0.54207746
89MP0003115_abnormal_respiratory_system0.53510919
90MP0002116_abnormal_craniofacial_bone0.53458843
91MP0001919_abnormal_reproductive_system0.53262078
92MP0002067_abnormal_sensory_capabilities0.53066881
93MP0010329_abnormal_lipoprotein_level0.52807256
94MP0002063_abnormal_learning/memory/cond0.52769518
95MP0003718_maternal_effect0.52371918
96MP0002734_abnormal_mechanical_nocicepti0.51969621
97MP0002109_abnormal_limb_morphology0.51370473
98MP0002111_abnormal_tail_morphology0.51314107
99MP0003861_abnormal_nervous_system0.50897779
100MP0005253_abnormal_eye_physiology0.50398022

Predicted human phenotypes

RankGene SetZ-score
1Partial duplication of thumb phalanx (HP:0009944)5.36334107
2Aplasia involving bones of the extremities (HP:0009825)5.21879036
3Aplasia involving bones of the upper limbs (HP:0009823)5.21879036
4Aplasia of the phalanges of the hand (HP:0009802)5.21879036
5Partial duplication of the phalanx of hand (HP:0009999)4.79787837
6Abnormality of the labia minora (HP:0012880)4.25721040
7Aqueductal stenosis (HP:0002410)3.87676664
8Septo-optic dysplasia (HP:0100842)3.81719937
9Abnormality of the middle phalanges of the toes (HP:0010183)3.78919855
10Amyotrophic lateral sclerosis (HP:0007354)3.69951337
11Duplication of thumb phalanx (HP:0009942)3.60535019
12Short 4th metacarpal (HP:0010044)3.58703454
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.58703454
14Absent septum pellucidum (HP:0001331)3.58333419
1511 pairs of ribs (HP:0000878)3.48820521
16Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)3.40108335
17Abnormality of the parietal bone (HP:0002696)3.36134843
18Alacrima (HP:0000522)3.35989240
19Neonatal short-limb short stature (HP:0008921)3.29242500
20Recurrent corneal erosions (HP:0000495)3.19322517
21Abnormality of the phalanges of the 2nd finger (HP:0009541)3.09933008
22Esophageal atresia (HP:0002032)3.06737862
23Coronal craniosynostosis (HP:0004440)3.02743174
24Xerostomia (HP:0000217)2.93774180
25Abnormality of the septum pellucidum (HP:0007375)2.93617369
26Overriding aorta (HP:0002623)2.93034005
27Nasolacrimal duct obstruction (HP:0000579)2.81992686
28Megalencephaly (HP:0001355)2.77645539
29Gastrointestinal atresia (HP:0002589)2.76124878
30Abnormality of the lacrimal duct (HP:0011481)2.70406787
31Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.69845784
32Vertebral hypoplasia (HP:0008417)2.69845784
33Limb hypertonia (HP:0002509)2.67123075
34Cerebellar dysplasia (HP:0007033)2.66612610
35Abnormality of the 4th metacarpal (HP:0010012)2.61202924
36Acute necrotizing encephalopathy (HP:0006965)2.53339579
37Stenosis of the external auditory canal (HP:0000402)2.50389927
38Congenital sensorineural hearing impairment (HP:0008527)2.48754683
39Short tibia (HP:0005736)2.46425473
40Preaxial foot polydactyly (HP:0001841)2.44124427
41Decreased lacrimation (HP:0000633)2.43914323
42Conical tooth (HP:0000698)2.43450727
43Synostosis involving the elbow (HP:0003938)2.42491701
44Humeroradial synostosis (HP:0003041)2.42491701
45Absent radius (HP:0003974)2.38644620
46Increased nuchal translucency (HP:0010880)2.36878326
47Stomach cancer (HP:0012126)2.35460961
48Limited elbow extension (HP:0001377)2.35418204
49Abnormal pupillary function (HP:0007686)2.33546613
50Abnormality of incisor morphology (HP:0011063)2.32999753
51Missing ribs (HP:0000921)2.32541898
52Abnormality of the 2nd finger (HP:0004100)2.31977883
53Cupped ear (HP:0000378)2.31701634
54Acute encephalopathy (HP:0006846)2.30942802
55Limb dystonia (HP:0002451)2.30650616
56Episodic fever (HP:0001954)2.29890221
57Abnormal lung lobation (HP:0002101)2.29198238
58Bronchomalacia (HP:0002780)2.27354496
59Aplasia/Hypoplasia of the tibia (HP:0005772)2.26266346
60Absent forearm bone (HP:0003953)2.25600388
61Aplasia involving forearm bones (HP:0009822)2.25600388
62Bifid scrotum (HP:0000048)2.25071681
63Abnormality of the nasolacrimal system (HP:0000614)2.23095711
64Progressive macrocephaly (HP:0004481)2.18104402
65Mitochondrial inheritance (HP:0001427)2.16438380
662-3 toe syndactyly (HP:0004691)2.15729338
67Abnormality of the distal phalanx of the thumb (HP:0009617)2.15703993
68Abnormal mitochondria in muscle tissue (HP:0008316)2.15308475
69Optic nerve hypoplasia (HP:0000609)2.14772656
70Reticulocytopenia (HP:0001896)2.14452219
71Broad metatarsal (HP:0001783)2.14057787
72Triphalangeal thumb (HP:0001199)2.13698188
73Congenital, generalized hypertrichosis (HP:0004540)2.13165406
74Abnormality of the corticospinal tract (HP:0002492)2.09835480
75Atrophy/Degeneration involving motor neurons (HP:0007373)2.04750981
76Down-sloping shoulders (HP:0200021)2.03153483
77Intestinal atresia (HP:0011100)2.01965112
78Vaginal atresia (HP:0000148)2.00247582
79Constricted visual fields (HP:0001133)1.98883261
80Genital tract atresia (HP:0001827)1.97278729
81Chronic otitis media (HP:0000389)1.96150963
82Maternal diabetes (HP:0009800)1.95378698
83Sex reversal (HP:0012245)1.95104535
84Abnormal sex determination (HP:0012244)1.95104535
85Short hallux (HP:0010109)1.95061641
86Mixed hearing impairment (HP:0000410)1.91153562
87Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.86046933
88Abnormality of the diencephalon (HP:0010662)1.85272532
89Supernumerary ribs (HP:0005815)1.85215330
90Split foot (HP:0001839)1.83511982
91Increased hepatocellular lipid droplets (HP:0006565)1.83331610
92Abnormality of permanent molar morphology (HP:0011071)1.81602099
93Abnormality of the dental root (HP:0006486)1.81602099
94Taurodontia (HP:0000679)1.81602099
95Increased CSF lactate (HP:0002490)1.80092708
96Symphalangism affecting the phalanges of the hand (HP:0009773)1.76077713
97Aplasia/Hypoplasia of the ulna (HP:0006495)1.74497604
98Cerebral edema (HP:0002181)1.74430042
99Aplasia/Hypoplasia of the hallux (HP:0008362)1.72909305
100Shoulder girdle muscle weakness (HP:0003547)1.72697833

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK6.81259742
2TNIK5.52154930
3FGFR23.55826739
4MAP3K102.99417526
5PLK42.90025139
6TAF12.51914825
7PINK12.51109575
8PBK2.46778476
9LIMK12.44632050
10ZAK2.33885991
11MARK12.31086431
12WEE12.22919170
13MINK12.16569317
14CAMK1G2.10145409
15ERBB32.00499977
16VRK11.88106770
17CASK1.71560425
18VRK21.57896602
19NUAK11.56431015
20SGK21.52234123
21TLK11.48812141
22PLK21.41945857
23WNK31.40906448
24CDC71.33605476
25SGK2231.23231483
26SGK4941.23231483
27TAOK31.22921215
28ACVR1B1.19750551
29DYRK21.17005746
30NLK1.16319933
31FGFR11.09292274
32TRIM281.06077743
33BRSK20.95782928
34PRKCH0.92188014
35PLK30.91922223
36BCKDK0.90278787
37ADRBK20.89808077
38KIT0.89116833
39RPS6KL10.83933184
40RPS6KC10.83933184
41CDK30.83383634
42RPS6KA60.81472267
43NME10.73483723
44BUB10.73457773
45FGFR30.71242872
46NEK90.70687307
47PIM20.68169222
48SGK30.67721534
49MAP2K10.66833072
50EPHB20.65147363
51RPS6KA20.61980648
52PRKCG0.61891218
53MAPK130.61856992
54MARK30.61041950
55EIF2AK20.58099036
56LATS10.57237879
57AURKA0.56305948
58ERBB40.53730271
59GRK50.52370825
60ADRBK10.51468749
61UHMK10.50704729
62DYRK30.50650126
63ROCK10.49079492
64CLK10.48957574
65SRPK10.48682671
66MST40.48446587
67STK160.47365848
68NEK20.46376869
69CSNK1G10.46041963
70YES10.46024319
71PKN10.45646026
72CDC42BPA0.43741097
73TSSK60.43513860
74CAMK10.42348426
75OBSCN0.41139000
76CHEK20.41097033
77PASK0.39325217
78INSRR0.39140594
79DYRK1A0.38479656
80MAP2K70.38298897
81PIM10.38111381
82TNK20.36116530
83BMPR1B0.35468365
84ATR0.34426296
85SGK10.33703969
86TYRO30.33571605
87NTRK20.33526247
88MAP3K60.33519088
89RPS6KB10.32411758
90ROCK20.32270765
91PLK10.30668035
92KDR0.29005376
93MATK0.28929767
94MAP4K20.23885170
95CCNB10.23221511
96FRK0.22590828
97DDR20.21738958
98ERBB20.21132082
99GRK10.20901291
100AURKB0.19558282

Predicted pathways (KEGG)

RankGene SetZ-score
1Parkinsons disease_Homo sapiens_hsa050123.94309925
2Oxidative phosphorylation_Homo sapiens_hsa001903.92276811
3Proteasome_Homo sapiens_hsa030503.58829471
4Protein export_Homo sapiens_hsa030603.19596779
5Ribosome_Homo sapiens_hsa030103.04113008
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.79107184
7Basal cell carcinoma_Homo sapiens_hsa052172.67283517
8Huntingtons disease_Homo sapiens_hsa050162.59489983
9Alzheimers disease_Homo sapiens_hsa050102.57067686
10RNA polymerase_Homo sapiens_hsa030202.55533719
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.24491454
12Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.01250071
13Cardiac muscle contraction_Homo sapiens_hsa042601.87975984
14Steroid biosynthesis_Homo sapiens_hsa001001.77073775
15RNA degradation_Homo sapiens_hsa030181.72197486
16Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.67071001
17Hedgehog signaling pathway_Homo sapiens_hsa043401.66842458
18Arginine biosynthesis_Homo sapiens_hsa002201.51393494
19Butanoate metabolism_Homo sapiens_hsa006501.49411867
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41398601
21GABAergic synapse_Homo sapiens_hsa047271.31968979
22Purine metabolism_Homo sapiens_hsa002301.29878727
23Taste transduction_Homo sapiens_hsa047421.26024271
24Morphine addiction_Homo sapiens_hsa050321.23343624
25Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.21663650
26Dorso-ventral axis formation_Homo sapiens_hsa043201.18946380
27Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16475632
28Fanconi anemia pathway_Homo sapiens_hsa034601.16288189
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.13801954
30Olfactory transduction_Homo sapiens_hsa047401.09248947
31Tyrosine metabolism_Homo sapiens_hsa003501.06944615
32Homologous recombination_Homo sapiens_hsa034401.03000161
33Melanogenesis_Homo sapiens_hsa049161.02416364
34Vitamin digestion and absorption_Homo sapiens_hsa049771.02168930
35Pyrimidine metabolism_Homo sapiens_hsa002401.01348901
36Primary immunodeficiency_Homo sapiens_hsa053401.00363485
37Phototransduction_Homo sapiens_hsa047440.94172714
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.94044452
39Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93934036
40Sulfur relay system_Homo sapiens_hsa041220.92237316
41Basal transcription factors_Homo sapiens_hsa030220.91124335
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86838634
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86530886
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84870052
45Selenocompound metabolism_Homo sapiens_hsa004500.83452458
46Phenylalanine metabolism_Homo sapiens_hsa003600.83336949
47Cell cycle_Homo sapiens_hsa041100.82918489
48Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82282754
49Chemical carcinogenesis_Homo sapiens_hsa052040.79373674
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78226286
51Alcoholism_Homo sapiens_hsa050340.76504713
52Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75505006
53Colorectal cancer_Homo sapiens_hsa052100.73927863
54Mismatch repair_Homo sapiens_hsa034300.72052249
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71092821
56Cocaine addiction_Homo sapiens_hsa050300.70891126
57Spliceosome_Homo sapiens_hsa030400.69344240
58Nicotine addiction_Homo sapiens_hsa050330.67881029
59Nitrogen metabolism_Homo sapiens_hsa009100.67415511
60Caffeine metabolism_Homo sapiens_hsa002320.65980258
61Oocyte meiosis_Homo sapiens_hsa041140.65617207
62Wnt signaling pathway_Homo sapiens_hsa043100.64993895
63Non-homologous end-joining_Homo sapiens_hsa034500.63058057
64Propanoate metabolism_Homo sapiens_hsa006400.60615243
65Vitamin B6 metabolism_Homo sapiens_hsa007500.60208494
66Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.59601904
67Hippo signaling pathway_Homo sapiens_hsa043900.58427000
68p53 signaling pathway_Homo sapiens_hsa041150.58250140
69Insulin secretion_Homo sapiens_hsa049110.57432803
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57148958
71Systemic lupus erythematosus_Homo sapiens_hsa053220.55899549
72DNA replication_Homo sapiens_hsa030300.55726536
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53204370
74Sulfur metabolism_Homo sapiens_hsa009200.52653610
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.50829168
76Circadian entrainment_Homo sapiens_hsa047130.50586813
77Retinol metabolism_Homo sapiens_hsa008300.48885967
78Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.48763144
79Peroxisome_Homo sapiens_hsa041460.46693477
80Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46125050
81Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45992426
82Glutamatergic synapse_Homo sapiens_hsa047240.45169594
83Metabolic pathways_Homo sapiens_hsa011000.44260977
84Prostate cancer_Homo sapiens_hsa052150.44174325
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43024921
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39073471
87Calcium signaling pathway_Homo sapiens_hsa040200.39055526
88TGF-beta signaling pathway_Homo sapiens_hsa043500.38296410
89Histidine metabolism_Homo sapiens_hsa003400.37724641
90Dopaminergic synapse_Homo sapiens_hsa047280.37695147
91mRNA surveillance pathway_Homo sapiens_hsa030150.37351656
92Renin-angiotensin system_Homo sapiens_hsa046140.37031204
93Antigen processing and presentation_Homo sapiens_hsa046120.36689124
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35746925
95One carbon pool by folate_Homo sapiens_hsa006700.34180567
96Starch and sucrose metabolism_Homo sapiens_hsa005000.32476857
97Ovarian steroidogenesis_Homo sapiens_hsa049130.32188677
98Fatty acid biosynthesis_Homo sapiens_hsa000610.32172230
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32163041
100Gap junction_Homo sapiens_hsa045400.29470115

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