CCDC58

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)4.65920690
2energy coupled proton transport, down electrochemical gradient (GO:0015985)4.61470616
3ATP synthesis coupled proton transport (GO:0015986)4.61470616
4ribosomal small subunit assembly (GO:0000028)4.58271740
5water-soluble vitamin biosynthetic process (GO:0042364)4.54391514
6nucleobase biosynthetic process (GO:0046112)4.49837874
7purine nucleobase biosynthetic process (GO:0009113)4.49052998
8DNA deamination (GO:0045006)4.47388293
9formation of translation preinitiation complex (GO:0001731)4.36306855
10mitochondrial respiratory chain complex I assembly (GO:0032981)4.32245038
11NADH dehydrogenase complex assembly (GO:0010257)4.32245038
12mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.32245038
13chaperone-mediated protein transport (GO:0072321)4.31977062
14protein complex biogenesis (GO:0070271)4.30828864
15proteasome assembly (GO:0043248)4.24316302
16ribosomal small subunit biogenesis (GO:0042274)4.21334547
17ribosomal large subunit biogenesis (GO:0042273)4.20840696
18mitotic metaphase plate congression (GO:0007080)4.19913149
19mitochondrial respiratory chain complex assembly (GO:0033108)4.14980590
20ribosome assembly (GO:0042255)4.10849765
21viral transcription (GO:0019083)4.10303462
22translational termination (GO:0006415)4.08463946
23mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.06654911
24DNA strand elongation involved in DNA replication (GO:0006271)3.99046214
25ribonucleoprotein complex biogenesis (GO:0022613)3.98543873
26protein neddylation (GO:0045116)3.92622989
27DNA replication initiation (GO:0006270)3.90970846
28ribosome biogenesis (GO:0042254)3.88714529
29CENP-A containing nucleosome assembly (GO:0034080)3.88380479
30chromatin remodeling at centromere (GO:0031055)3.84702266
31DNA strand elongation (GO:0022616)3.84286645
32telomere maintenance via semi-conservative replication (GO:0032201)3.80967542
33DNA replication checkpoint (GO:0000076)3.79208839
34translational elongation (GO:0006414)3.75506698
35nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.73872845
36translational initiation (GO:0006413)3.70692175
37behavioral response to nicotine (GO:0035095)3.70504178
38rRNA modification (GO:0000154)3.64608626
39folic acid-containing compound biosynthetic process (GO:0009396)3.62970850
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.59466294
41spliceosomal snRNP assembly (GO:0000387)3.59086538
42metaphase plate congression (GO:0051310)3.58827246
43folic acid metabolic process (GO:0046655)3.54073333
44kinetochore organization (GO:0051383)3.52386946
45SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.52211213
46rRNA processing (GO:0006364)3.51590514
47anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.50948050
48tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.48782026
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.48782026
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.48508090
51respiratory electron transport chain (GO:0022904)3.47455086
52regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.47346513
53kinetochore assembly (GO:0051382)3.46555946
54telomere maintenance via recombination (GO:0000722)3.45330367
55electron transport chain (GO:0022900)3.44642739
56cotranslational protein targeting to membrane (GO:0006613)3.44512897
57pseudouridine synthesis (GO:0001522)3.42971392
58protein targeting to ER (GO:0045047)3.41965756
59translation (GO:0006412)3.40503595
60maturation of 5.8S rRNA (GO:0000460)3.37846061
61nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.37391638
62transcription elongation from RNA polymerase III promoter (GO:0006385)3.37249552
63termination of RNA polymerase III transcription (GO:0006386)3.37249552
64rRNA metabolic process (GO:0016072)3.37046591
65DNA replication-independent nucleosome assembly (GO:0006336)3.35305891
66DNA replication-independent nucleosome organization (GO:0034724)3.35305891
67IMP biosynthetic process (GO:0006188)3.32207160
68regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.28428868
69cellular component biogenesis (GO:0044085)3.28278329
70DNA replication-dependent nucleosome assembly (GO:0006335)3.28003305
71DNA replication-dependent nucleosome organization (GO:0034723)3.28003305
727-methylguanosine mRNA capping (GO:0006370)3.26794389
73negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.25579021
74negative regulation of ligase activity (GO:0051352)3.25579021
75protein localization to endoplasmic reticulum (GO:0070972)3.24520383
76mitotic recombination (GO:0006312)3.23831181
77transcription-coupled nucleotide-excision repair (GO:0006283)3.23674967
78establishment of integrated proviral latency (GO:0075713)3.23384728
79protein localization to kinetochore (GO:0034501)3.23354351
80establishment of protein localization to endoplasmic reticulum (GO:0072599)3.23178508
81regulation of mitochondrial translation (GO:0070129)3.22253752
82spliceosomal complex assembly (GO:0000245)3.21271809
83RNA capping (GO:0036260)3.20664723
847-methylguanosine RNA capping (GO:0009452)3.20664723
85cellular protein complex disassembly (GO:0043624)3.20329305
86telomere maintenance via telomere lengthening (GO:0010833)3.20320881
87histone exchange (GO:0043486)3.18928428
88DNA unwinding involved in DNA replication (GO:0006268)3.18007416
89mitotic nuclear envelope disassembly (GO:0007077)3.16258164
90termination of RNA polymerase I transcription (GO:0006363)3.14727256
91viral life cycle (GO:0019058)3.14549368
92establishment of protein localization to mitochondrial membrane (GO:0090151)3.13584379
93positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.12821708
94regulation of cellular amino acid metabolic process (GO:0006521)3.11599132
95establishment of chromosome localization (GO:0051303)3.11369364
96transcription elongation from RNA polymerase I promoter (GO:0006362)3.10787029
97transcription from RNA polymerase I promoter (GO:0006360)3.09872670
98DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.08873577
99replication fork processing (GO:0031297)3.07348863
100regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.06311014
101protein-cofactor linkage (GO:0018065)3.05376429
102respiratory chain complex IV assembly (GO:0008535)3.05026398
103signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.05006132
104intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.05006132
105cullin deneddylation (GO:0010388)3.04129624
106signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.03930942
107signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.03930942
108signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.03930942
109signal transduction involved in DNA integrity checkpoint (GO:0072401)3.02306053
110signal transduction involved in DNA damage checkpoint (GO:0072422)3.02306053
111DNA double-strand break processing (GO:0000729)2.99333468
112glycine metabolic process (GO:0006544)2.98869046
113positive regulation of ligase activity (GO:0051351)2.97277169
114signal transduction involved in cell cycle checkpoint (GO:0072395)2.96924322
115cell cycle G1/S phase transition (GO:0044843)2.96192748
116G1/S transition of mitotic cell cycle (GO:0000082)2.96192748
117protein deneddylation (GO:0000338)2.94231832
118IMP metabolic process (GO:0046040)2.93400647
119L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.92981678
120protein targeting to mitochondrion (GO:0006626)2.92505184
121rRNA methylation (GO:0031167)2.92463851
122RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90194579
123nucleotide-excision repair, DNA gap filling (GO:0006297)2.90156610
124exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.89439783
125tRNA processing (GO:0008033)2.88295173
126regulation of spindle organization (GO:0090224)2.87694810
127mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.86446542
128sulfation (GO:0051923)2.83494032
129isotype switching (GO:0045190)2.80843401
130somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.80843401
131somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.80843401
132cytochrome complex assembly (GO:0017004)2.79366474
133establishment of protein localization to mitochondrion (GO:0072655)2.77037845
134ATP biosynthetic process (GO:0006754)2.76981698
135regulation of mitotic spindle checkpoint (GO:1903504)2.72686341
136regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.72686341
137protein K6-linked ubiquitination (GO:0085020)2.70745542
138purine nucleoside triphosphate biosynthetic process (GO:0009145)2.69141225
139protein localization to mitochondrion (GO:0070585)2.67802245
140preassembly of GPI anchor in ER membrane (GO:0016254)2.67353847
141intracellular protein transmembrane import (GO:0044743)2.66268963
142regulation of mesoderm development (GO:2000380)2.65890805
143DNA catabolic process, exonucleolytic (GO:0000738)2.65798863
144purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.65023865
145regulation of DNA endoreduplication (GO:0032875)2.63869596
146protein polyglutamylation (GO:0018095)2.62818908
147platelet dense granule organization (GO:0060155)2.61993090
148mannosylation (GO:0097502)2.60466157
149recombinational repair (GO:0000725)2.56760593
150tRNA metabolic process (GO:0006399)2.55985349
151negative regulation of DNA-dependent DNA replication (GO:2000104)2.54818839
152ncRNA processing (GO:0034470)2.53696778
153double-strand break repair via homologous recombination (GO:0000724)2.53330963
154synapsis (GO:0007129)2.52935555
155ncRNA metabolic process (GO:0034660)2.52643462
156DNA damage response, detection of DNA damage (GO:0042769)2.51871922
157GPI anchor metabolic process (GO:0006505)2.51870367
158peptidyl-histidine modification (GO:0018202)2.51549500

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.41457144
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.54551589
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.91744031
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.66847553
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.40261884
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.33407139
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.26595044
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.17119921
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.16811799
10* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.09793455
11FOXM1_23109430_ChIP-Seq_U2OS_Human3.06980835
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.04287693
13CREB1_15753290_ChIP-ChIP_HEK293T_Human3.04155386
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.98587495
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.96624275
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.81930680
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.79845012
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.63113515
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58841951
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.47144760
21ZNF274_21170338_ChIP-Seq_K562_Hela2.46112502
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.42071575
23XRN2_22483619_ChIP-Seq_HELA_Human2.37577340
24VDR_23849224_ChIP-Seq_CD4+_Human2.33765246
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.30588820
26VDR_22108803_ChIP-Seq_LS180_Human2.27616030
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.25544852
28DCP1A_22483619_ChIP-Seq_HELA_Human2.17009590
29* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.13023833
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.10900940
31FOXP3_21729870_ChIP-Seq_TREG_Human1.99127780
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95825772
33GABP_19822575_ChIP-Seq_HepG2_Human1.92961861
34NANOG_18555785_ChIP-Seq_MESCs_Mouse1.92109385
35* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91724087
36AR_21909140_ChIP-Seq_LNCAP_Human1.90026526
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87900782
38EWS_26573619_Chip-Seq_HEK293_Human1.87659252
39FUS_26573619_Chip-Seq_HEK293_Human1.86304753
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.85752692
41* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85461501
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84216043
43TTF2_22483619_ChIP-Seq_HELA_Human1.82479255
44IRF1_19129219_ChIP-ChIP_H3396_Human1.78395338
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.75811248
46ELK1_19687146_ChIP-ChIP_HELA_Human1.74727330
47* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74692158
48* SRF_21415370_ChIP-Seq_HL-1_Mouse1.74575572
49IGF1R_20145208_ChIP-Seq_DFB_Human1.71270306
50* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63570219
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.62223830
52* YY1_21170310_ChIP-Seq_MESCs_Mouse1.60966370
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60761366
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.55990081
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52698580
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.52474686
57* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52115500
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.51448959
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.50655818
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46096263
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43802390
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42633622
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41896366
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.40691432
65* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39199160
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37657758
67KDM5A_27292631_Chip-Seq_BREAST_Human1.37656818
68CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.34960275
69TAF15_26573619_Chip-Seq_HEK293_Human1.33126022
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32032284
71POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29755986
72PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29524894
73ZFP57_27257070_Chip-Seq_ESCs_Mouse1.29270302
74TP53_22573176_ChIP-Seq_HFKS_Human1.28451886
75P300_19829295_ChIP-Seq_ESCs_Human1.28028931
76SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.26892096
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.24787529
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.23850684
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23681907
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.23297923
81BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22193300
82PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21703432
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21660450
84* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18685725
85RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17025063
86GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16525844
87CIITA_25753668_ChIP-Seq_RAJI_Human1.15237847
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.14578664
89ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14058822
90ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.13877402
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.13659616
92ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.13598767
93NANOG_16153702_ChIP-ChIP_HESCs_Human1.13306554
94KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.11796720
95KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.11796720
96KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.11796720
97FOXA1_25329375_ChIP-Seq_VCAP_Human1.11734779
98FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11734779
99* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11529686
100TCF3_18692474_ChIP-Seq_MEFs_Mouse1.09819939
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.09335936
102CTBP2_25329375_ChIP-Seq_LNCAP_Human1.08191915
103ELK1_22589737_ChIP-Seq_MCF10A_Human1.07492343
104MYC_18940864_ChIP-ChIP_HL60_Human1.07320346
105HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06453529
106SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05776820
107ER_23166858_ChIP-Seq_MCF-7_Human1.05636022
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04875407
109AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04766660
110SOX2_16153702_ChIP-ChIP_HESCs_Human1.03535469
111NANOG_19829295_ChIP-Seq_ESCs_Human1.01528685
112SOX2_19829295_ChIP-Seq_ESCs_Human1.01528685
113NFE2_27457419_Chip-Seq_LIVER_Mouse1.01223957
114E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01005422
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00929606
116GBX2_23144817_ChIP-Seq_PC3_Human1.00264359
117TFEB_21752829_ChIP-Seq_HELA_Human0.99710077
118SOX2_18692474_ChIP-Seq_MEFs_Mouse0.99356909
119SUZ12_27294783_Chip-Seq_NPCs_Mouse0.98514535
120GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.97631173
121NCOR_22424771_ChIP-Seq_293T_Human0.97505802
122CBP_20019798_ChIP-Seq_JUKART_Human0.97051317
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97051317
124HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.97024841
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95552190
126OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94712149
127CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94615275
128AR_20517297_ChIP-Seq_VCAP_Human0.94043500
129CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93842011
130CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92952280
131NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.92362256
132EZH2_27294783_Chip-Seq_NPCs_Mouse0.91977527
133FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91237764
134KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89865249
135UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.89686037
136EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89679721
137* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88877339
138NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.88635786
139NOTCH1_21737748_ChIP-Seq_TLL_Human0.88576352
140* SOX17_20123909_ChIP-Seq_XEN_Mouse0.87042386
141RNF2_27304074_Chip-Seq_NSC_Mouse0.86989067
142PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83696111
143KLF5_20875108_ChIP-Seq_MESCs_Mouse0.83529037
144HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82716876
145* NANOG_21062744_ChIP-ChIP_HESCs_Human0.80181885
146NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.78153173

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.53552336
2MP0003806_abnormal_nucleotide_metabolis4.65562219
3MP0004957_abnormal_blastocyst_morpholog4.54401063
4MP0003111_abnormal_nucleus_morphology4.05742363
5MP0010094_abnormal_chromosome_stability4.05328644
6MP0003077_abnormal_cell_cycle3.72475760
7MP0008058_abnormal_DNA_repair3.23557501
8MP0008057_abnormal_DNA_replication3.15077896
9MP0008932_abnormal_embryonic_tissue2.74803455
10MP0003718_maternal_effect2.67196732
11MP0002102_abnormal_ear_morphology2.59762091
12MP0006072_abnormal_retinal_apoptosis2.48663220
13MP0008007_abnormal_cellular_replicative2.44929754
14MP0005646_abnormal_pituitary_gland2.36056055
15MP0003123_paternal_imprinting2.26241850
16MP0001730_embryonic_growth_arrest2.23484158
17MP0003186_abnormal_redox_activity2.20140564
18MP0002837_dystrophic_cardiac_calcinosis2.10831092
19MP0002139_abnormal_hepatobiliary_system1.89338948
20MP0000350_abnormal_cell_proliferation1.87137598
21MP0004145_abnormal_muscle_electrophysio1.84304305
22MP0001485_abnormal_pinna_reflex1.81132807
23MP0005360_urolithiasis1.76782833
24MP0003786_premature_aging1.76705809
25MP0005551_abnormal_eye_electrophysiolog1.69905192
26MP0008872_abnormal_physiological_respon1.69627278
27MP0006036_abnormal_mitochondrial_physio1.67998431
28MP0001529_abnormal_vocalization1.64639524
29MP0002876_abnormal_thyroid_physiology1.63842721
30MP0005380_embryogenesis_phenotype1.63111066
31MP0001672_abnormal_embryogenesis/_devel1.63111066
32MP0000372_irregular_coat_pigmentation1.62193006
33MP0008789_abnormal_olfactory_epithelium1.61492950
34MP0005085_abnormal_gallbladder_physiolo1.60572647
35MP0001697_abnormal_embryo_size1.60440320
36MP0002163_abnormal_gland_morphology1.60345816
37MP0000049_abnormal_middle_ear1.58213788
38MP0002234_abnormal_pharynx_morphology1.55751532
39MP0005084_abnormal_gallbladder_morpholo1.55417493
40MP0002138_abnormal_hepatobiliary_system1.54143591
41MP0006035_abnormal_mitochondrial_morpho1.53769944
42MP0008877_abnormal_DNA_methylation1.53517365
43MP0004133_heterotaxia1.51058974
44MP0000631_abnormal_neuroendocrine_gland1.47472073
45MP0010352_gastrointestinal_tract_polyps1.46171445
46MP0009697_abnormal_copulation1.45030809
47MP0003984_embryonic_growth_retardation1.44656926
48MP0003011_delayed_dark_adaptation1.44465546
49MP0002080_prenatal_lethality1.43587320
50MP0001968_abnormal_touch/_nociception1.41694550
51MP0002088_abnormal_embryonic_growth/wei1.41414933
52MP0005253_abnormal_eye_physiology1.39303943
53MP0009379_abnormal_foot_pigmentation1.38352834
54MP0002396_abnormal_hematopoietic_system1.37423006
55MP0004147_increased_porphyrin_level1.36489762
56MP0001293_anophthalmia1.34072447
57MP0002085_abnormal_embryonic_tissue1.33392017
58MP0005645_abnormal_hypothalamus_physiol1.32150653
59MP0003567_abnormal_fetal_cardiomyocyte1.32029367
60MP0010030_abnormal_orbit_morphology1.29865381
61MP0003136_yellow_coat_color1.29421041
62MP0000313_abnormal_cell_death1.26631759
63MP0003890_abnormal_embryonic-extraembry1.26550585
64MP0004142_abnormal_muscle_tone1.26471557
65MP0002638_abnormal_pupillary_reflex1.25767620
66MP0003941_abnormal_skin_development1.24908410
67MP0003315_abnormal_perineum_morphology1.24117172
68MP0001764_abnormal_homeostasis1.22575552
69MP0005365_abnormal_bile_salt1.20685160
70MP0002736_abnormal_nociception_after1.19367258
71MP0006292_abnormal_olfactory_placode1.19012786
72MP0004885_abnormal_endolymph1.17563138
73MP0002086_abnormal_extraembryonic_tissu1.17336088
74MP0002210_abnormal_sex_determination1.15588235
75MP0010307_abnormal_tumor_latency1.14953964
76MP0002084_abnormal_developmental_patter1.14493263
77MP0005266_abnormal_metabolism1.13971265
78MP0004197_abnormal_fetal_growth/weight/1.13302572
79MP0002019_abnormal_tumor_incidence1.12185263
80MP0002132_abnormal_respiratory_system1.11955517
81MP0003787_abnormal_imprinting1.09989562
82MP0000490_abnormal_crypts_of1.09561815
83MP0000358_abnormal_cell_content/1.09117224
84MP0003938_abnormal_ear_development1.07635873
85MP0008995_early_reproductive_senescence1.07062650
86MP0001984_abnormal_olfaction1.07013876
87MP0009840_abnormal_foam_cell1.04847448
88MP0009333_abnormal_splenocyte_physiolog1.04764059
89MP0001145_abnormal_male_reproductive1.03779608
90MP0002160_abnormal_reproductive_system1.01545663
91MP0005408_hypopigmentation1.01458881
92MP0005379_endocrine/exocrine_gland_phen0.98827241
93MP0005332_abnormal_amino_acid0.97963516
94MP0003878_abnormal_ear_physiology0.97686981
95MP0005377_hearing/vestibular/ear_phenot0.97686981
96MP0005670_abnormal_white_adipose0.97188152
97MP0005389_reproductive_system_phenotype0.94406128
98MP0000653_abnormal_sex_gland0.93084577
99MP0005395_other_phenotype0.93070087
100MP0005410_abnormal_fertilization0.91825084
101MP0005195_abnormal_posterior_eye0.90892112
102MP0006276_abnormal_autonomic_nervous0.89777657
103MP0002272_abnormal_nervous_system0.89619898
104MP0001929_abnormal_gametogenesis0.88212842
105MP0005394_taste/olfaction_phenotype0.88093642
106MP0005499_abnormal_olfactory_system0.88093642
107MP0005671_abnormal_response_to0.87419197
108MP0009053_abnormal_anal_canal0.86965868
109MP0003119_abnormal_digestive_system0.85973523
110MP0009672_abnormal_birth_weight0.85834440
111MP0001905_abnormal_dopamine_level0.85568156
112MP0008875_abnormal_xenobiotic_pharmacok0.84514023
113MP0001873_stomach_inflammation0.84257624
114MP0001119_abnormal_female_reproductive0.83629321
115MP0009250_abnormal_appendicular_skeleto0.81968063
116MP0003221_abnormal_cardiomyocyte_apopto0.79903592
117MP0002751_abnormal_autonomic_nervous0.79305460
118MP0001188_hyperpigmentation0.77744679
119MP0002111_abnormal_tail_morphology0.77468889
120MP0000598_abnormal_liver_morphology0.76434289
121MP0003880_abnormal_central_pattern0.75705576
122MP0004215_abnormal_myocardial_fiber0.75667922
123MP0005319_abnormal_enzyme/_coenzyme0.75453580
124MP0009745_abnormal_behavioral_response0.75071400
125MP0002277_abnormal_respiratory_mucosa0.73741470
126MP0000647_abnormal_sebaceous_gland0.73099012
127MP0003698_abnormal_male_reproductive0.72765336
128MP0005451_abnormal_body_composition0.72359521
129MP0001286_abnormal_eye_development0.71856600
130MP0005636_abnormal_mineral_homeostasis0.71174561
131MP0004742_abnormal_vestibular_system0.71149836
132MP0003638_abnormal_response/metabolism_0.70813046
133MP0005075_abnormal_melanosome_morpholog0.70684171
134MP0001919_abnormal_reproductive_system0.68975724
135MP0003937_abnormal_limbs/digits/tail_de0.67814742
136MP0000750_abnormal_muscle_regeneration0.66882898
137MP0005376_homeostasis/metabolism_phenot0.65640950
138MP0000537_abnormal_urethra_morphology0.65591757
139MP0002938_white_spotting0.65128672
140MP0003646_muscle_fatigue0.63901145
141MP0005384_cellular_phenotype0.61553058
142MP0001853_heart_inflammation0.60661592
143MP0001661_extended_life_span0.58348794
144MP0000609_abnormal_liver_physiology0.58248331
145MP0004019_abnormal_vitamin_homeostasis0.57664078
146MP0002092_abnormal_eye_morphology0.57656782
147MP0005023_abnormal_wound_healing0.55989946
148MP0001727_abnormal_embryo_implantation0.55166701
149MP0003195_calcinosis0.53375585
150MP0002653_abnormal_ependyma_morphology0.52919697
151MP0005083_abnormal_biliary_tract0.52798923
152MP0003121_genomic_imprinting0.52780700
153MP0003699_abnormal_female_reproductive0.52685384
154MP0002722_abnormal_immune_system0.50845005
155MP0000858_altered_metastatic_potential0.50703070
156MP0000689_abnormal_spleen_morphology0.50385150
157MP0002269_muscular_atrophy0.49840252

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.86248304
2Breast hypoplasia (HP:0003187)4.24185847
3Abnormality of cells of the erythroid lineage (HP:0012130)4.21564018
4Reticulocytopenia (HP:0001896)4.21443752
5Abnormal number of erythroid precursors (HP:0012131)3.90523135
6Oral leukoplakia (HP:0002745)3.78901065
7Macrocytic anemia (HP:0001972)3.42018231
8Acute necrotizing encephalopathy (HP:0006965)3.25038749
9Carpal bone hypoplasia (HP:0001498)3.21718333
10Hepatic necrosis (HP:0002605)3.18076221
11Hepatocellular necrosis (HP:0001404)3.18060860
12Rough bone trabeculation (HP:0100670)3.17696492
13Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.16747805
14Decreased activity of mitochondrial respiratory chain (HP:0008972)3.16747805
15Pancreatic cysts (HP:0001737)3.13184626
16Methylmalonic acidemia (HP:0002912)3.10881669
17Increased serum pyruvate (HP:0003542)3.09413587
18Abnormality of glycolysis (HP:0004366)3.09413587
19Colon cancer (HP:0003003)3.09216470
20Abnormality of pyrimidine metabolism (HP:0004353)3.06411128
21Cerebral hypomyelination (HP:0006808)3.04199517
22Abnormal mitochondria in muscle tissue (HP:0008316)3.02375947
23Acute encephalopathy (HP:0006846)2.99885949
24Increased CSF lactate (HP:0002490)2.98184383
25Increased serum lactate (HP:0002151)2.97773097
26Multiple enchondromatosis (HP:0005701)2.96659666
27Pancreatic fibrosis (HP:0100732)2.94707618
28True hermaphroditism (HP:0010459)2.90140261
29Pendular nystagmus (HP:0012043)2.88528453
30Patellar aplasia (HP:0006443)2.87820866
31Mitochondrial inheritance (HP:0001427)2.87729923
32Abnormality of the anterior horn cell (HP:0006802)2.84371362
33Degeneration of anterior horn cells (HP:0002398)2.84371362
34Cerebral edema (HP:0002181)2.80543553
35Hypobetalipoproteinemia (HP:0003563)2.80203597
36Aplasia/Hypoplasia of the patella (HP:0006498)2.73115247
37Abnormality of alanine metabolism (HP:0010916)2.71232250
38Hyperalaninemia (HP:0003348)2.71232250
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.71232250
40Hyperglycinemia (HP:0002154)2.70854244
41Pallor (HP:0000980)2.66014427
42Stenosis of the external auditory canal (HP:0000402)2.63924786
43Supernumerary spleens (HP:0009799)2.63921803
44Absent radius (HP:0003974)2.62418995
45Aplastic anemia (HP:0001915)2.61920646
46Nephronophthisis (HP:0000090)2.58693883
47Abolished electroretinogram (ERG) (HP:0000550)2.54406579
48Abnormality of midbrain morphology (HP:0002418)2.52582235
49Molar tooth sign on MRI (HP:0002419)2.52582235
50Congenital, generalized hypertrichosis (HP:0004540)2.51917009
51Microretrognathia (HP:0000308)2.50375352
52Methylmalonic aciduria (HP:0012120)2.48005792
53Aplasia involving forearm bones (HP:0009822)2.47786801
54Absent forearm bone (HP:0003953)2.47786801
55Renal cortical cysts (HP:0000803)2.47475299
56Abnormality of monocarboxylic acid metabolism (HP:0010996)2.46835523
57Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.46688988
58Premature graying of hair (HP:0002216)2.45570826
59Abnormal trabecular bone morphology (HP:0100671)2.44784429
60Megaloblastic anemia (HP:0001889)2.44545175
61Selective tooth agenesis (HP:0001592)2.43437960
62Progressive macrocephaly (HP:0004481)2.43189756
63Medulloblastoma (HP:0002885)2.41858816
64Microvesicular hepatic steatosis (HP:0001414)2.39466793
65Congenital stationary night blindness (HP:0007642)2.39427023
66Lipid accumulation in hepatocytes (HP:0006561)2.39408794
673-Methylglutaconic aciduria (HP:0003535)2.39390344
68Aplasia/Hypoplasia of the uvula (HP:0010293)2.39375183
69Impulsivity (HP:0100710)2.37198054
70Increased hepatocellular lipid droplets (HP:0006565)2.36437192
71Premature ovarian failure (HP:0008209)2.34259026
72Cellular immunodeficiency (HP:0005374)2.34042542
73Hyperglycinuria (HP:0003108)2.33167907
74Abnormality of serum amino acid levels (HP:0003112)2.33074113
75Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.32470256
76CNS demyelination (HP:0007305)2.31041068
77Renal Fanconi syndrome (HP:0001994)2.30694336
78Chromsome breakage (HP:0040012)2.30439787
79Optic disc pallor (HP:0000543)2.30123183
80Nausea (HP:0002018)2.30014099
81Lethargy (HP:0001254)2.29214484
82Absent thumb (HP:0009777)2.29001566
83Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.28810605
84Meckel diverticulum (HP:0002245)2.26474799
85Horseshoe kidney (HP:0000085)2.26000193
86Lactic acidosis (HP:0003128)2.25945163
87Abnormality of the renal cortex (HP:0011035)2.25665287
88Abnormality of the renal collecting system (HP:0004742)2.25664037
89Secondary amenorrhea (HP:0000869)2.25230945
90Trismus (HP:0000211)2.24469229
91Rhabdomyosarcoma (HP:0002859)2.24074017
92Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.21393566
93Abnormality of the phalanges of the 5th finger (HP:0004213)2.18502206
94Aplasia/hypoplasia of the uterus (HP:0008684)2.18075197
95Aplasia/Hypoplasia of the sacrum (HP:0008517)2.18044255
96Exercise intolerance (HP:0003546)2.17866897
97Abnormality of glycine metabolism (HP:0010895)2.16586064
98Abnormality of serine family amino acid metabolism (HP:0010894)2.16586064
99Increased intramyocellular lipid droplets (HP:0012240)2.14894613
100Neoplasm of the pancreas (HP:0002894)2.13342899
101Hypoplasia of the uterus (HP:0000013)2.13198119
102Respiratory failure (HP:0002878)2.12338085
103Abnormality of the preputium (HP:0100587)2.10711877
104Chromosomal breakage induced by crosslinking agents (HP:0003221)2.10124330
105Abnormality of the ileum (HP:0001549)2.09869251
106Abnormality of the proximal phalanges of the hand (HP:0009834)2.08931238
107Sclerocornea (HP:0000647)2.08562563
108Abnormal lung lobation (HP:0002101)2.08017410
109Asplenia (HP:0001746)2.07811198
110Abnormality of methionine metabolism (HP:0010901)2.06929070
111Aplasia/Hypoplasia of the spleen (HP:0010451)2.05139358
112Decreased electroretinogram (ERG) amplitude (HP:0000654)2.04519399
113Abnormality of aspartate family amino acid metabolism (HP:0010899)2.04042347
114Abnormality of the renal medulla (HP:0100957)2.03821643
115Ependymoma (HP:0002888)2.02053369
116Attenuation of retinal blood vessels (HP:0007843)2.01540282
117Sparse eyelashes (HP:0000653)2.01014486
118Abnormality of aromatic amino acid family metabolism (HP:0004338)1.99635991
119Abnormality of chromosome stability (HP:0003220)1.99242959
120Pancytopenia (HP:0001876)1.98951000
121Poor head control (HP:0002421)1.97152841
122Bone marrow hypocellularity (HP:0005528)1.96691925
123Medial flaring of the eyebrow (HP:0010747)1.95805743
124Cleft eyelid (HP:0000625)1.95523320
125Aplasia/Hypoplasia involving the musculature (HP:0001460)1.94403868
126Agnosia (HP:0010524)1.92996442
127Progressive external ophthalmoplegia (HP:0000590)1.92305501
128Absent rod-and cone-mediated responses on ERG (HP:0007688)1.90429766
129Abnormality of the labia minora (HP:0012880)1.90321720
130Intrahepatic cholestasis (HP:0001406)1.89918503
131Short tibia (HP:0005736)1.88868524
132Duplicated collecting system (HP:0000081)1.87561978
133Ureteral duplication (HP:0000073)1.87557475
134Hyperammonemia (HP:0001987)1.84053223
135IgG deficiency (HP:0004315)1.83922726
136Triphalangeal thumb (HP:0001199)1.83917148
137Abnormality of reticulocytes (HP:0004312)1.83116893
138Glycosuria (HP:0003076)1.82704202
139Abnormality of urine glucose concentration (HP:0011016)1.82704202
140Abnormality of DNA repair (HP:0003254)1.82197607
141Progressive muscle weakness (HP:0003323)1.82042490
142Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.81982294
143Aplasia/Hypoplasia of the tibia (HP:0005772)1.81963472
144Hypoplasia of the pons (HP:0012110)1.81161850
145Leukodystrophy (HP:0002415)1.80062272
146Dicarboxylic aciduria (HP:0003215)1.78994973
147Male pseudohermaphroditism (HP:0000037)1.78879650
148Abnormal rod and cone electroretinograms (HP:0008323)1.78275337
149Abnormality of the phalanges of the 2nd finger (HP:0009541)1.74878535
150Abnormality of the pons (HP:0007361)1.74703943
151Increased muscle lipid content (HP:0009058)1.74452439
152Abnormality of the vitamin B12 metabolism (HP:0004341)1.71933873
153Abnormality of the middle phalanges of the toes (HP:0010183)1.70658179
154Abnormality of vitamin B metabolism (HP:0004340)1.69917615
155Abnormality of renal resorption (HP:0011038)1.66052091
156Chorioretinal atrophy (HP:0000533)1.66001064
157Small hand (HP:0200055)1.64531945

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.12237275
2WEE14.52548944
3EIF2AK13.65639723
4VRK23.53441649
5NME23.14853171
6CDC72.96647446
7SRPK12.85687160
8STK162.65390395
9ADRBK22.56392745
10PLK42.56084624
11FRK2.45184784
12TESK22.37844464
13BRSK22.35136650
14EIF2AK32.34463277
15GRK12.29714607
16TTK2.24239506
17MAP4K22.12037449
18TLK12.09775239
19BMPR1B2.08815721
20NEK22.08458732
21NEK11.98450660
22VRK11.91783751
23PLK11.91171849
24EPHA21.88979669
25TSSK61.80824750
26BCKDK1.76638954
27WNK31.75932694
28TAF11.75114560
29MKNK11.72054915
30ACVR1B1.71142453
31PBK1.66770077
32TAOK31.56816591
33AURKB1.56230921
34PLK31.55148025
35WNK41.52914720
36CDK71.51595645
37DYRK31.49285718
38TXK1.48268979
39RPS6KB21.44225558
40AURKA1.37407242
41ZAK1.36236339
42STK38L1.32028002
43ATR1.30343349
44STK391.30330311
45PINK11.28624363
46TRIM281.27816041
47BRSK11.25936466
48MAP3K81.21760038
49CHEK21.20250151
50MKNK21.18618485
51PASK1.18016925
52OXSR11.17116873
53PLK21.17053516
54KDR1.16160908
55RPS6KA41.13083040
56NME11.06783932
57CDK41.03511382
58PAK41.02293891
59FLT31.02089983
60BRAF1.00412377
61CSNK1G30.98520278
62STK40.97218285
63CSNK1G10.96024550
64CHEK10.94983372
65STK100.91714476
66CSNK1G20.90179024
67MAP3K40.89483578
68INSRR0.89189941
69MAP3K110.86651433
70TNIK0.86576036
71EIF2AK20.86475088
72TESK10.85752725
73PIM20.85458797
74TIE10.85287128
75CSNK2A10.84053169
76ABL20.83886750
77MAP2K70.83680565
78CSNK1A1L0.83567855
79CSNK2A20.81897212
80PNCK0.81257670
81MAPKAPK50.80738767
82CCNB10.76795656
83IRAK30.75039741
84PRKCG0.71125168
85AKT30.70967015
86PIM10.70734581
87ERBB30.69601532
88GRK70.68907588
89PAK10.66047832
90CDK20.65911590
91ATM0.65643907
92LATS20.64814690
93DAPK10.64013856
94PRKCI0.60374064
95DYRK20.60085677
96CDK190.58633072
97CDK80.58392411
98BCR0.58059531
99TGFBR10.57309820
100ADRBK10.57165045
101GRK50.56714267
102MUSK0.56089766
103PHKG10.55912457
104PHKG20.55912457
105RPS6KA50.55690015
106LRRK20.55451212
107TEC0.55302328
108PIK3CA0.52916669
109PDK40.52499833
110PDK30.52499833
111CASK0.49708163
112LIMK10.49646367
113ILK0.49609198
114MAPK130.48358827
115CDK10.47572397
116MELK0.46549030
117PRKCE0.46353805
118CDK90.44959164
119CSNK1A10.44423269
120CDK120.43646927
121PKN20.42661091
122MST40.42352264
123CDK60.41943007
124MAP2K30.41478765
125IKBKB0.41387497
126MARK30.41247035
127STK30.40159198
128PDK20.39205451
129BRD40.36591214
130ALK0.36553329
131OBSCN0.35689444
132MAP3K100.35546555
133SCYL20.35518029
134PRKACA0.35120220
135CSNK1E0.34207412
136MAP3K120.32870225
137NEK90.31443287
138ERBB40.30970687
139MAPKAPK30.27542946
140AKT20.27348185
141TAOK20.26861931
142MAP3K30.26413678
143ARAF0.23284356
144PRKDC0.19400090
145NUAK10.18753442
146STK240.18399101

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.93993517
2Proteasome_Homo sapiens_hsa030503.86048877
3DNA replication_Homo sapiens_hsa030303.79807285
4RNA polymerase_Homo sapiens_hsa030203.45980977
5Mismatch repair_Homo sapiens_hsa034303.41744724
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.32561238
7Spliceosome_Homo sapiens_hsa030402.78707399
8RNA transport_Homo sapiens_hsa030132.59662246
9Pyrimidine metabolism_Homo sapiens_hsa002402.52824324
10One carbon pool by folate_Homo sapiens_hsa006702.46071379
11Nucleotide excision repair_Homo sapiens_hsa034202.43072111
12Homologous recombination_Homo sapiens_hsa034402.41384610
13Base excision repair_Homo sapiens_hsa034102.24878650
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.12766775
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.82745289
16Cell cycle_Homo sapiens_hsa041101.81671638
17Basal transcription factors_Homo sapiens_hsa030221.68986605
18Folate biosynthesis_Homo sapiens_hsa007901.65365560
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.62847859
20Fanconi anemia pathway_Homo sapiens_hsa034601.62832429
21RNA degradation_Homo sapiens_hsa030181.57258802
22Non-homologous end-joining_Homo sapiens_hsa034501.51957765
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.51605281
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.43957888
25Phototransduction_Homo sapiens_hsa047441.43551786
26Sulfur metabolism_Homo sapiens_hsa009201.43404687
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.42830047
28Oxidative phosphorylation_Homo sapiens_hsa001901.39653764
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38458585
30Parkinsons disease_Homo sapiens_hsa050121.37310721
31Purine metabolism_Homo sapiens_hsa002301.31175977
32Selenocompound metabolism_Homo sapiens_hsa004501.31113441
33Biosynthesis of amino acids_Homo sapiens_hsa012301.30450359
34Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27071129
35Huntingtons disease_Homo sapiens_hsa050161.25203440
36Cardiac muscle contraction_Homo sapiens_hsa042601.24430059
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.23953529
38Protein export_Homo sapiens_hsa030601.23602315
39Vitamin B6 metabolism_Homo sapiens_hsa007501.22714174
40Butanoate metabolism_Homo sapiens_hsa006501.16048904
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14875442
42Carbon metabolism_Homo sapiens_hsa012001.12258720
43mRNA surveillance pathway_Homo sapiens_hsa030151.08919466
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.06619840
45Nitrogen metabolism_Homo sapiens_hsa009101.06378019
46Sulfur relay system_Homo sapiens_hsa041221.05845982
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.04575851
48p53 signaling pathway_Homo sapiens_hsa041151.04063953
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03278767
50Glutathione metabolism_Homo sapiens_hsa004801.02245629
51Pentose phosphate pathway_Homo sapiens_hsa000301.01380644
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.99369182
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97510130
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.87647420
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87241456
56Systemic lupus erythematosus_Homo sapiens_hsa053220.83752214
57Epstein-Barr virus infection_Homo sapiens_hsa051690.83582801
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.82917392
59Primary immunodeficiency_Homo sapiens_hsa053400.82084830
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81235762
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80980928
62alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76675968
63Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73970380
64Pyruvate metabolism_Homo sapiens_hsa006200.73545596
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70311765
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.70040469
67Peroxisome_Homo sapiens_hsa041460.69926282
68Arginine and proline metabolism_Homo sapiens_hsa003300.68825340
69Propanoate metabolism_Homo sapiens_hsa006400.68050000
70Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66335719
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.66172113
72Nicotine addiction_Homo sapiens_hsa050330.65934603
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.65027232
74Metabolic pathways_Homo sapiens_hsa011000.64584207
75Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61778850
76Alzheimers disease_Homo sapiens_hsa050100.61439974
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.60886235
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57744222
79Fructose and mannose metabolism_Homo sapiens_hsa000510.56546263
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54187505
81Phenylalanine metabolism_Homo sapiens_hsa003600.54187345
82Olfactory transduction_Homo sapiens_hsa047400.53714991
83Fatty acid degradation_Homo sapiens_hsa000710.53216220
84Chemical carcinogenesis_Homo sapiens_hsa052040.51429760
85Tyrosine metabolism_Homo sapiens_hsa003500.51092664
86beta-Alanine metabolism_Homo sapiens_hsa004100.50677509
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.50342774
88Arginine biosynthesis_Homo sapiens_hsa002200.49924807
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49724251
90Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47440380
91Ether lipid metabolism_Homo sapiens_hsa005650.47346058
92Steroid biosynthesis_Homo sapiens_hsa001000.47290691
93Retinol metabolism_Homo sapiens_hsa008300.45406508
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43916899
95Tryptophan metabolism_Homo sapiens_hsa003800.43642583
96Oocyte meiosis_Homo sapiens_hsa041140.42507073
97Taste transduction_Homo sapiens_hsa047420.41375150
98Intestinal immune network for IgA production_Homo sapiens_hsa046720.41344835
99Fatty acid elongation_Homo sapiens_hsa000620.40897455
100Herpes simplex infection_Homo sapiens_hsa051680.40640853
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39995573
102Galactose metabolism_Homo sapiens_hsa000520.39924294
103Asthma_Homo sapiens_hsa053100.36539813
104Viral carcinogenesis_Homo sapiens_hsa052030.35318203
105Glycerolipid metabolism_Homo sapiens_hsa005610.33861995
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32696007
107Starch and sucrose metabolism_Homo sapiens_hsa005000.32046258
108Vitamin digestion and absorption_Homo sapiens_hsa049770.31417078
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.30052490
110Legionellosis_Homo sapiens_hsa051340.29572087
111Histidine metabolism_Homo sapiens_hsa003400.29141287
112Arachidonic acid metabolism_Homo sapiens_hsa005900.28684487
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28621843
114Antigen processing and presentation_Homo sapiens_hsa046120.27691637
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26647017
116Fat digestion and absorption_Homo sapiens_hsa049750.26483162
117Collecting duct acid secretion_Homo sapiens_hsa049660.25404056
118Linoleic acid metabolism_Homo sapiens_hsa005910.24919934
119Fatty acid metabolism_Homo sapiens_hsa012120.22449350
120Thyroid cancer_Homo sapiens_hsa052160.20978380
121Regulation of autophagy_Homo sapiens_hsa041400.19941880
122HTLV-I infection_Homo sapiens_hsa051660.18979405
123Complement and coagulation cascades_Homo sapiens_hsa046100.18757667
124Caffeine metabolism_Homo sapiens_hsa002320.18636809

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