CCDC57

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)9.09907449
2transcription from mitochondrial promoter (GO:0006390)8.34464367
3axonemal dynein complex assembly (GO:0070286)8.04896554
4proline metabolic process (GO:0006560)7.80337182
5replication fork processing (GO:0031297)7.70316120
6embryonic process involved in female pregnancy (GO:0060136)6.86196301
7motile cilium assembly (GO:0044458)6.73289469
8cilium movement (GO:0003341)6.49906287
9positive regulation of protein homooligomerization (GO:0032464)6.48381587
10DNA deamination (GO:0045006)6.44254453
11maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.39843397
12oxidative demethylation (GO:0070989)6.01611538
13establishment of apical/basal cell polarity (GO:0035089)5.89735360
14regulation of integrin activation (GO:0033623)5.70248078
15regulation of protein homooligomerization (GO:0032462)5.53045013
16DNA strand renaturation (GO:0000733)5.45329613
17somatic hypermutation of immunoglobulin genes (GO:0016446)5.36763951
18somatic diversification of immune receptors via somatic mutation (GO:0002566)5.36763951
19axoneme assembly (GO:0035082)5.33534154
20mitochondrial DNA metabolic process (GO:0032042)5.23820960
21poly(A)+ mRNA export from nucleus (GO:0016973)5.14039414
22establishment or maintenance of monopolar cell polarity (GO:0061339)5.12001934
23establishment of monopolar cell polarity (GO:0061162)5.12001934
24viral mRNA export from host cell nucleus (GO:0046784)5.01802392
25mitotic G1 DNA damage checkpoint (GO:0031571)4.87846599
26negative regulation of JAK-STAT cascade (GO:0046426)4.54506163
27negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.52315508
28spliceosomal tri-snRNP complex assembly (GO:0000244)4.46500720
29cellular response to ATP (GO:0071318)4.41014744
30G1 DNA damage checkpoint (GO:0044783)4.39114879
31regulation of translational fidelity (GO:0006450)4.32953958
32mRNA cleavage (GO:0006379)4.32332560
33negative regulation of cell cycle arrest (GO:0071157)4.31931245
34negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.23368865
35base-excision repair (GO:0006284)4.21692395
36mannose metabolic process (GO:0006013)4.21517879
37establishment of protein localization to mitochondrial membrane (GO:0090151)4.21491433
38mitotic G1/S transition checkpoint (GO:0044819)4.20171109
39glutamine family amino acid biosynthetic process (GO:0009084)4.18521395
40DNA integration (GO:0015074)4.14014382
41embryonic placenta development (GO:0001892)4.13119272
42telomere maintenance via semi-conservative replication (GO:0032201)4.11109638
43negative regulation of Ras GTPase activity (GO:0034261)4.02895325
44positive regulation of developmental pigmentation (GO:0048087)3.97830576
45dosage compensation (GO:0007549)3.94813200
46nucleotide-excision repair, DNA gap filling (GO:0006297)3.93107392
47regulation of RNA export from nucleus (GO:0046831)3.88404405
48positive regulation of CREB transcription factor activity (GO:0032793)3.85541200
49epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.84196427
50convergent extension (GO:0060026)3.82400747
51formation of translation preinitiation complex (GO:0001731)3.82144511
52histone H3-K4 trimethylation (GO:0080182)3.79421042
53positive regulation of mitotic sister chromatid separation (GO:1901970)3.78803762
54positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.78803762
55positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.78803762
56tolerance induction (GO:0002507)3.77836122
57negative regulation of fatty acid biosynthetic process (GO:0045717)3.77727513
58regulation of cytokine production involved in inflammatory response (GO:1900015)3.76868379
59negative regulation of mRNA processing (GO:0050686)3.75377190
60embryonic camera-type eye development (GO:0031076)3.72414745
61regulation of double-strand break repair via homologous recombination (GO:0010569)3.71229906
62histone H4-K12 acetylation (GO:0043983)3.66168515
63DNA topological change (GO:0006265)3.62872859
64double-strand break repair via nonhomologous end joining (GO:0006303)3.62546048
65non-recombinational repair (GO:0000726)3.62546048
66negative regulation of protein oligomerization (GO:0032460)3.61524196
67mitochondrial RNA metabolic process (GO:0000959)3.61249669
68face development (GO:0060324)3.61104280
69cellular response to zinc ion (GO:0071294)3.60580554
70DNA double-strand break processing (GO:0000729)3.60181386
71behavioral response to nicotine (GO:0035095)3.59051189
72positive regulation of protein kinase C signaling (GO:0090037)3.56549656
73termination of RNA polymerase II transcription (GO:0006369)3.55037575
74base-excision repair, AP site formation (GO:0006285)3.54754035
75positive regulation by host of viral transcription (GO:0043923)3.53756491
76positive regulation of protein oligomerization (GO:0032461)3.52304156
77meiotic chromosome segregation (GO:0045132)3.52102284
78regulation of sister chromatid cohesion (GO:0007063)3.51960227
79labyrinthine layer development (GO:0060711)3.51383324
80regulation of cilium movement (GO:0003352)3.49530808
81kinetochore assembly (GO:0051382)3.42933554
82histone H3-K9 methylation (GO:0051567)3.42016131
83negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.38184931
84phosphatidylglycerol biosynthetic process (GO:0006655)3.38017094
85cellular response to exogenous dsRNA (GO:0071360)3.37278316
86regulation of DNA damage checkpoint (GO:2000001)3.36664780
87telomere maintenance via recombination (GO:0000722)3.35401519
88DNA demethylation (GO:0080111)3.34646694
89maturation of 5.8S rRNA (GO:0000460)3.34459757
90regulation of protein oligomerization (GO:0032459)3.34449713
91regulation of double-strand break repair (GO:2000779)3.34017271
92single strand break repair (GO:0000012)3.32681183
93positive regulation of DNA repair (GO:0045739)3.31952137
94pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.31289472
95left/right pattern formation (GO:0060972)3.29794585
96DNA strand elongation involved in DNA replication (GO:0006271)3.26675185
97phosphatidylethanolamine biosynthetic process (GO:0006646)3.25704539
98glial cell migration (GO:0008347)3.25575713
99left/right axis specification (GO:0070986)3.24381315
100DNA ligation (GO:0006266)3.22991878
101negative regulation of appetite (GO:0032099)3.20129253
102negative regulation of response to food (GO:0032096)3.20129253
103detection of light stimulus involved in visual perception (GO:0050908)3.19916701
104detection of light stimulus involved in sensory perception (GO:0050962)3.19916701
105purinergic nucleotide receptor signaling pathway (GO:0035590)3.19575236
106resolution of meiotic recombination intermediates (GO:0000712)3.18523962
107negative regulation of RNA splicing (GO:0033119)3.16158997
108regulation of cAMP-dependent protein kinase activity (GO:2000479)3.14855273
109trophectodermal cell differentiation (GO:0001829)3.14511567
110histone H3-K9 modification (GO:0061647)3.13569754
111positive regulation of histone deacetylation (GO:0031065)3.12284436
112epithelial cilium movement (GO:0003351)3.11988172
113positive regulation of chromosome segregation (GO:0051984)3.10985736
114activation of Rac GTPase activity (GO:0032863)3.09583871
115positive regulation of defense response to virus by host (GO:0002230)3.09089783
116DNA strand elongation (GO:0022616)3.06221221
117cilium organization (GO:0044782)3.03941335
118ventricular system development (GO:0021591)3.02321705
119anatomical structure regression (GO:0060033)3.02223629
120negative regulation of mRNA metabolic process (GO:1903312)2.98928398
121cilium assembly (GO:0042384)2.98125383
122GDP-mannose metabolic process (GO:0019673)2.96253010
123regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.96202851
124mRNA polyadenylation (GO:0006378)2.94913681
125positive regulation of receptor recycling (GO:0001921)2.94377173
126regulation of gamma-delta T cell differentiation (GO:0045586)2.93599996
127regulation of cell size (GO:0008361)2.93153728
128apoptotic process involved in morphogenesis (GO:0060561)2.92191914
129positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.91901252
130phosphatidylethanolamine metabolic process (GO:0046337)2.91864037
131cardiolipin metabolic process (GO:0032048)2.91814758
132regulation of skeletal muscle contraction (GO:0014819)2.91276064
133urinary tract smooth muscle contraction (GO:0014848)2.82452258
134microtubule bundle formation (GO:0001578)2.80456406
135lung epithelium development (GO:0060428)2.79970814
136regulation of hippo signaling (GO:0035330)2.76384064
137regulation of hydrogen peroxide metabolic process (GO:0010310)2.76126327
138histone H3-K4 methylation (GO:0051568)2.75822918
139peptidyl-lysine methylation (GO:0018022)2.75721924
140semaphorin-plexin signaling pathway (GO:0071526)2.74245697
141sperm motility (GO:0030317)2.74129382
142positive thymic T cell selection (GO:0045059)2.72618345
143negative regulation of interleukin-8 production (GO:0032717)2.71904654
144negative regulation of T cell differentiation in thymus (GO:0033085)2.71648011
145histone lysine methylation (GO:0034968)2.68939126
146negative regulation of granulocyte differentiation (GO:0030853)2.67384151
147regulation of microtubule-based movement (GO:0060632)2.65231161
148regulation of cilium assembly (GO:1902017)2.63773429
149cornea development in camera-type eye (GO:0061303)2.62215708
150regulation of gamma-delta T cell activation (GO:0046643)2.61914666
151vitamin transmembrane transport (GO:0035461)2.61903150
152sensory perception of taste (GO:0050909)2.61861411
153positive T cell selection (GO:0043368)2.59329918
154cilium morphogenesis (GO:0060271)2.56302338
155positive regulation of Rab GTPase activity (GO:0032851)2.55915033
156regulation of Rab GTPase activity (GO:0032313)2.55915033
157peptidyl-lysine trimethylation (GO:0018023)2.52188618
158mitotic cell cycle arrest (GO:0071850)2.52057405
159protein localization to cilium (GO:0061512)2.51901067
160positive regulation of protein deacetylation (GO:0090312)2.51818977
161response to muramyl dipeptide (GO:0032495)2.42946940
162sex determination (GO:0007530)2.42119470
163transepithelial transport (GO:0070633)2.41616394
164nephron epithelium morphogenesis (GO:0072088)2.41528574
165nephron tubule morphogenesis (GO:0072078)2.41528574
166regulation of ARF GTPase activity (GO:0032312)2.41523520
167positive regulation of fatty acid beta-oxidation (GO:0032000)2.40791442
168thymic T cell selection (GO:0045061)2.40367780
169negative regulation of translation, ncRNA-mediated (GO:0040033)2.39595812
170regulation of translation, ncRNA-mediated (GO:0045974)2.39595812
171negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.39595812
172positive regulation of granulocyte differentiation (GO:0030854)2.36461468
173negative thymic T cell selection (GO:0045060)2.36263848
174negative T cell selection (GO:0043383)2.35764347
175regulation of histone deacetylation (GO:0031063)2.35743126
176DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.33009437
177negative regulation of cAMP-mediated signaling (GO:0043951)2.32964827
178regulation of fatty acid beta-oxidation (GO:0031998)2.31541645
179phosphatidylcholine biosynthetic process (GO:0006656)2.29392973
180negative regulation of B cell mediated immunity (GO:0002713)2.29209228
181negative regulation of immunoglobulin mediated immune response (GO:0002890)2.29209228
182fucose catabolic process (GO:0019317)2.28433980
183L-fucose metabolic process (GO:0042354)2.28433980
184L-fucose catabolic process (GO:0042355)2.28433980
185intraciliary transport (GO:0042073)2.27148974
186NAD biosynthetic process (GO:0009435)2.26644076
187regulation of interleukin-6 biosynthetic process (GO:0045408)2.26198899
188cellular response to ethanol (GO:0071361)2.25739431
189regulation of granulocyte differentiation (GO:0030852)2.25220954
190negative regulation of TOR signaling (GO:0032007)2.24685277
191snRNA processing (GO:0016180)2.23987459
192regulation of interleukin-12 biosynthetic process (GO:0045075)2.23968374
193cellular anion homeostasis (GO:0030002)2.23773416
194collecting duct development (GO:0072044)2.23327267
195proline biosynthetic process (GO:0006561)10.3880382

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.54307547
2ZFP281_18358816_ChIP-ChIP_MESCs_Mouse3.32979036
3E2F7_22180533_ChIP-Seq_HELA_Human3.15670224
4CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human3.07747014
5* DROSHA_22980978_ChIP-Seq_HELA_Human2.84726704
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.80691101
7SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.72895001
8KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.69211708
9KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.69211708
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.69211708
11P68_20966046_ChIP-Seq_HELA_Human2.67399302
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.55535863
13* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.44294028
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.43698746
15SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.41149657
16VDR_21846776_ChIP-Seq_THP-1_Human2.39366668
17NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.39262344
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.36666966
19POU5F1_16518401_ChIP-PET_MESCs_Mouse2.23293265
20SMC4_20622854_ChIP-Seq_HELA_Human2.18927241
21STAT6_21828071_ChIP-Seq_BEAS2B_Human2.17909966
22BCL6_27268052_Chip-Seq_Bcells_Human2.14302841
23KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.11691715
24ERG_21242973_ChIP-ChIP_JURKAT_Human2.05869525
25MYC_19079543_ChIP-ChIP_MESCs_Mouse2.05635766
26FOXM1_23109430_ChIP-Seq_U2OS_Human2.05013048
27CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.98526748
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.97842837
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.97152304
30* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96984577
31TCF3_18692474_ChIP-Seq_MESCs_Mouse1.95930132
32* LXR_22292898_ChIP-Seq_THP-1_Human1.94366292
33NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.93545288
34ELF1_20517297_ChIP-Seq_JURKAT_Human1.93193416
35SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.92817528
36NANOG_21062744_ChIP-ChIP_HESCs_Human1.92394729
37MAF_26560356_Chip-Seq_TH2_Human1.92260621
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92226022
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.89540672
40CTCF_27219007_Chip-Seq_Bcells_Human1.89388607
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.87917519
42PU.1_20513432_ChIP-Seq_Bcells_Mouse1.82597981
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.78931123
44* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.76467226
45MAF_26560356_Chip-Seq_TH1_Human1.75532086
46SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.73206624
47RUNX1_27514584_Chip-Seq_MCF-7_Human1.72695561
48VDR_24763502_ChIP-Seq_THP-1_Human1.72335706
49TCF7_22412390_ChIP-Seq_EML_Mouse1.71624671
50ERA_21632823_ChIP-Seq_H3396_Human1.71041445
51TET1_21451524_ChIP-Seq_MESCs_Mouse1.70788498
52MYC_19030024_ChIP-ChIP_MESCs_Mouse1.69108413
53UTX_26944678_Chip-Seq_JUKART_Human1.65212219
54SCL_19346495_ChIP-Seq_HPC-7_Human1.61479418
55MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.61420345
56YY1_21170310_ChIP-Seq_MESCs_Mouse1.60561817
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60185597
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.59550033
59TP63_22573176_ChIP-Seq_HFKS_Human1.59112935
60EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.58464262
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54152726
62NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.53554765
63NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52540528
64MYC_22102868_ChIP-Seq_BL_Human1.52531976
65CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.52506283
66* SA1_27219007_Chip-Seq_ERYTHROID_Human1.52489747
67RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.52014188
68CREB1_26743006_Chip-Seq_LNCaP_Human1.52002761
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.51940892
70* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.48234502
71MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.47860250
72KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47339311
73FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.47176884
74P300_27268052_Chip-Seq_Bcells_Human1.46654249
75CTCF_20526341_ChIP-Seq_ESCs_Human1.46187360
76CTCF_27219007_Chip-Seq_ERYTHROID_Human1.45850760
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.45849538
78MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45607675
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45174748
80ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44926297
81* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44919306
82TCF3_18692474_ChIP-Seq_MEFs_Mouse1.43280914
83ZNF263_19887448_ChIP-Seq_K562_Human1.43048241
84* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.42333324
85TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.42237760
86CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.41431846
87OCT4_19829295_ChIP-Seq_ESCs_Human1.40713260
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40341658
89* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.39274678
90NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.39143076
91ZFP281_18757296_ChIP-ChIP_E14_Mouse1.38900708
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38099355
93RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.37099544
94ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37089297
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.36851726
96ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.36484545
97SALL1_21062744_ChIP-ChIP_HESCs_Human1.35351638
98* TP53_22127205_ChIP-Seq_IMR90_Human1.35280395
99SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35237077
100PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34230220
101ETS1_21867929_ChIP-Seq_TH2_Mouse1.32833910
102SOX2_18692474_ChIP-Seq_MESCs_Mouse1.32768303
103GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32578345
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30854580
105POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30726398
106SA1_27219007_Chip-Seq_Bcells_Human1.30072224
107POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29930160
108SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29331012
109GATA1_19941827_ChIP-Seq_MEL_Mouse1.29161897
110RACK7_27058665_Chip-Seq_MCF-7_Human1.28718485
111OCT4_20526341_ChIP-Seq_ESCs_Human1.28709619
112* RARB_24833708_ChIP-Seq_LIVER_Mouse1.28403455
113NANOG_18692474_ChIP-Seq_MESCs_Mouse1.25651403
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25470048
115E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24768703
116PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.23648857
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23398460
118* KDM2B_26808549_Chip-Seq_JURKAT_Human1.22370293
119SPI1_26923725_Chip-Seq_HPCs_Mouse1.22365650
120KDM5A_27292631_Chip-Seq_BREAST_Human1.20889677
121* GABP_19822575_ChIP-Seq_HepG2_Human1.20795183
122PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.19893242
123* RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19025530
124ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.18286898
125CTCF_21964334_ChIP-Seq_BJAB-B_Human1.18151368
126PHF8_20622854_ChIP-Seq_HELA_Human1.17889919
127E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17364850
128SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.15948969
129E2F1_20622854_ChIP-Seq_HELA_Human1.15783505
130KDM2B_26808549_Chip-Seq_K562_Human1.15740300
131SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.15726378
132KDM2B_26808549_Chip-Seq_DND41_Human1.15525322
133SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15270922
134EZH2_27294783_Chip-Seq_ESCs_Mouse1.14363364
135* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.13971691
136KDM2B_26808549_Chip-Seq_SUP-B15_Human1.13962656
137P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.13879810
138GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.13617890
139DNAJC2_21179169_ChIP-ChIP_NT2_Human1.12922832
140* RARA_24833708_ChIP-Seq_LIVER_Mouse1.12827338
141* ELK3_25401928_ChIP-Seq_HUVEC_Human1.12757709
142RAC3_21632823_ChIP-Seq_H3396_Human1.12721225
143RARG_19884340_ChIP-ChIP_MEFs_Mouse1.12531984
144* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12251273
145VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12233713
146SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10963896
147DCP1A_22483619_ChIP-Seq_HELA_Human1.10770158
148* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.10360845
149E2F1_21310950_ChIP-Seq_MCF-7_Human1.10138296
150CIITA_25753668_ChIP-Seq_RAJI_Human1.10109740
151MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10006223
152ESR1_21235772_ChIP-Seq_MCF-7_Human1.09860632
153RUNX1_22412390_ChIP-Seq_EML_Mouse1.09818927
154YY1_22570637_ChIP-Seq_MALME-3M_Human1.09763808
155CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.09658409
156TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09526376
157TP53_23651856_ChIP-Seq_MEFs_Mouse1.09309871
158GATA1_19941826_ChIP-Seq_K562_Human1.09071141
159KAP1_27257070_Chip-Seq_ESCs_Mouse1.08778477
160RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.08554833
161CTCF_21964334_Chip-Seq_Bcells_Human1.08550109
162SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08538668
163BCOR_27268052_Chip-Seq_Bcells_Human1.08308229
164ETS1_20019798_ChIP-Seq_JURKAT_Human1.07936678
165NANOG_16518401_ChIP-PET_MESCs_Mouse1.06745932
166MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05048810
167FOXP1_21924763_ChIP-Seq_HESCs_Human1.04801420
168SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03515532
169TP63_19390658_ChIP-ChIP_HaCaT_Human1.02938564
170ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.02676576
171TAF2_19829295_ChIP-Seq_ESCs_Human1.01015891
172SUZ12_27294783_Chip-Seq_ESCs_Mouse1.00840266
173CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.99572602
174STAT1_20625510_ChIP-Seq_HELA_Human0.98987511
175EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.98927861
176* NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98791377
177BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.98082104

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.25157760
2MP0005171_absent_coat_pigmentation4.28228530
3MP0010030_abnormal_orbit_morphology4.20449585
4MP0009278_abnormal_bone_marrow4.18570674
5MP0008875_abnormal_xenobiotic_pharmacok4.10687763
6MP0004233_abnormal_muscle_weight3.33184327
7MP0001986_abnormal_taste_sensitivity3.32330482
8MP0004043_abnormal_pH_regulation3.22626766
9MP0002009_preneoplasia3.02015346
10MP0008995_early_reproductive_senescence2.81773092
11MP0010094_abnormal_chromosome_stability2.71729027
12MP0003890_abnormal_embryonic-extraembry2.52049933
13MP0004381_abnormal_hair_follicle2.48154256
14MP0004133_heterotaxia2.35896282
15MP0003878_abnormal_ear_physiology2.35134340
16MP0005377_hearing/vestibular/ear_phenot2.35134340
17MP0008877_abnormal_DNA_methylation2.28976523
18MP0002249_abnormal_larynx_morphology2.28764685
19MP0002653_abnormal_ependyma_morphology2.28339085
20MP0003283_abnormal_digestive_organ2.25857729
21MP0006072_abnormal_retinal_apoptosis2.20572592
22MP0003786_premature_aging2.16397788
23MP0001545_abnormal_hematopoietic_system2.13638273
24MP0005397_hematopoietic_system_phenotyp2.13638273
25MP0004130_abnormal_muscle_cell2.11121802
26MP0005174_abnormal_tail_pigmentation2.10484920
27MP0005083_abnormal_biliary_tract2.10323348
28MP0003119_abnormal_digestive_system1.98907074
29MP0008058_abnormal_DNA_repair1.98801626
30MP0001502_abnormal_circadian_rhythm1.94213475
31MP0001873_stomach_inflammation1.92935307
32MP0002933_joint_inflammation1.91526870
33MP0001293_anophthalmia1.91356903
34MP0003111_abnormal_nucleus_morphology1.91073746
35MP0003436_decreased_susceptibility_to1.89923505
36MP0005423_abnormal_somatic_nervous1.84929427
37MP0004957_abnormal_blastocyst_morpholog1.81662271
38MP0002282_abnormal_trachea_morphology1.76983779
39MP0003045_fibrosis1.73094200
40MP0003763_abnormal_thymus_physiology1.68765508
41MP0001765_abnormal_ion_homeostasis1.66460401
42MP0000579_abnormal_nail_morphology1.65675684
43MP0008961_abnormal_basal_metabolism1.64263114
44MP0002084_abnormal_developmental_patter1.61189576
45MP0005076_abnormal_cell_differentiation1.52229961
46MP0005075_abnormal_melanosome_morpholog1.51795639
47MP0002086_abnormal_extraembryonic_tissu1.49603633
48MP0008932_abnormal_embryonic_tissue1.48950819
49MP0000015_abnormal_ear_pigmentation1.48473268
50MP0001968_abnormal_touch/_nociception1.46976093
51MP0005551_abnormal_eye_electrophysiolog1.46725121
52MP0002928_abnormal_bile_duct1.45717625
53MP0002085_abnormal_embryonic_tissue1.43919668
54MP0001697_abnormal_embryo_size1.43310142
55MP0003693_abnormal_embryo_hatching1.42378342
56MP0000685_abnormal_immune_system1.42219715
57MP0000371_diluted_coat_color1.40461653
58MP0003172_abnormal_lysosome_physiology1.39947074
59MP0001348_abnormal_lacrimal_gland1.39378248
60MP0000383_abnormal_hair_follicle1.36489543
61MP0000013_abnormal_adipose_tissue1.36488762
62MP0003453_abnormal_keratinocyte_physiol1.35216267
63MP0001800_abnormal_humoral_immune1.32570872
64MP0004197_abnormal_fetal_growth/weight/1.30695597
65MP0010352_gastrointestinal_tract_polyps1.30449835
66MP0003646_muscle_fatigue1.30214247
67MP0003077_abnormal_cell_cycle1.29403904
68MP0002269_muscular_atrophy1.27636602
69MP0005058_abnormal_lysosome_morphology1.25146302
70MP0001672_abnormal_embryogenesis/_devel1.22686515
71MP0005380_embryogenesis_phenotype1.22686515
72MP0001790_abnormal_immune_system1.22605830
73MP0005387_immune_system_phenotype1.22605830
74MP0001756_abnormal_urination1.21671657
75MP0000470_abnormal_stomach_morphology1.20352472
76MP0000639_abnormal_adrenal_gland1.18727747
77MP0010155_abnormal_intestine_physiology1.18297373
78MP0002168_other_aberrant_phenotype1.16804096
79MP0005310_abnormal_salivary_gland1.16503656
80MP0002876_abnormal_thyroid_physiology1.14756794
81MP0005409_darkened_coat_color1.14220870
82MP0003755_abnormal_palate_morphology1.13749132
83MP0002735_abnormal_chemical_nociception1.13545009
84MP0002638_abnormal_pupillary_reflex1.13249168
85MP0003866_abnormal_defecation1.11811384
86MP0005671_abnormal_response_to1.11352809
87MP0002723_abnormal_immune_serum1.10577987
88MP0009053_abnormal_anal_canal1.10550794
89MP0001340_abnormal_eyelid_morphology1.09814434
90MP0002075_abnormal_coat/hair_pigmentati1.07061760
91MP0002111_abnormal_tail_morphology1.06850511
92MP0000462_abnormal_digestive_system1.05638184
93MP0002405_respiratory_system_inflammati1.05548657
94MP0001835_abnormal_antigen_presentation1.04949556
95MP0005025_abnormal_response_to1.04423838
96MP0002277_abnormal_respiratory_mucosa1.04255984
97MP0000350_abnormal_cell_proliferation1.03447686
98MP0001324_abnormal_eye_pigmentation1.03068214
99MP0001730_embryonic_growth_arrest1.02785753
100MP0003935_abnormal_craniofacial_develop1.02753575
101MP0003567_abnormal_fetal_cardiomyocyte1.02462771
102MP0000003_abnormal_adipose_tissue1.02300426
103MP0000490_abnormal_crypts_of1.01839235
104MP0002932_abnormal_joint_morphology1.00976462
105MP0005220_abnormal_exocrine_pancreas1.00935001
106MP0003656_abnormal_erythrocyte_physiolo1.00763422
107MP0006292_abnormal_olfactory_placode1.00149121
108MP0001145_abnormal_male_reproductive0.99778587
109MP0000538_abnormal_urinary_bladder0.99318481
110MP0001929_abnormal_gametogenesis0.97048392
111MP0001664_abnormal_digestion0.96491797
112MP0002452_abnormal_antigen_presenting0.96075771
113MP0001819_abnormal_immune_cell0.95968770
114MP0002080_prenatal_lethality0.95804117
115MP0002136_abnormal_kidney_physiology0.95546319
116MP0001501_abnormal_sleep_pattern0.95322302
117MP0002420_abnormal_adaptive_immunity0.95179206
118MP0003195_calcinosis0.93912408
119MP0001970_abnormal_pain_threshold0.93904499
120MP0003136_yellow_coat_color0.93166799
121MP0002114_abnormal_axial_skeleton0.92653410
122MP0002160_abnormal_reproductive_system0.92487556
123MP0003137_abnormal_impulse_conducting0.92260931
124MP0008872_abnormal_physiological_respon0.92040590
125MP0003718_maternal_effect0.91322898
126MP0005253_abnormal_eye_physiology0.91235512
127MP0003984_embryonic_growth_retardation0.90770077
128MP0005645_abnormal_hypothalamus_physiol0.89814833
129MP0009643_abnormal_urine_homeostasis0.89053556
130MP0001270_distended_abdomen0.88292584
131MP0002116_abnormal_craniofacial_bone0.88205788
132MP0001919_abnormal_reproductive_system0.87804741
133MP0002210_abnormal_sex_determination0.87306485
134MP0005365_abnormal_bile_salt0.85762300
135MP0000703_abnormal_thymus_morphology0.85554995
136MP0001186_pigmentation_phenotype0.85116094
137MP0002088_abnormal_embryonic_growth/wei0.84634375
138MP0000716_abnormal_immune_system0.84178123
139MP0005448_abnormal_energy_balance0.84116359
140MP0004264_abnormal_extraembryonic_tissu0.82052624
141MP0005391_vision/eye_phenotype0.81766959
142MP0003698_abnormal_male_reproductive0.80834752
143MP0002019_abnormal_tumor_incidence0.80378498
144MP0009115_abnormal_fat_cell0.79706535
145MP0010307_abnormal_tumor_latency0.79653712
146MP0000762_abnormal_tongue_morphology0.79488960
147MP0002419_abnormal_innate_immunity0.79210888
148MP0005410_abnormal_fertilization0.78869173
149MP0000432_abnormal_head_morphology0.78828962
150MP0000566_synostosis0.78589680
151MP0002398_abnormal_bone_marrow0.77057263
152MP0000653_abnormal_sex_gland0.76560341
153MP0005248_abnormal_Harderian_gland0.76284745
154MP0002161_abnormal_fertility/fecundity0.74553006
155MP0000049_abnormal_middle_ear0.73808563
156MP0005389_reproductive_system_phenotype0.72781585
157MP0001661_extended_life_span0.72458549
158MP0005266_abnormal_metabolism0.70932491
159MP0002132_abnormal_respiratory_system0.70814353
160MP0002796_impaired_skin_barrier0.70550193
161MP0004947_skin_inflammation0.69608784
162MP0002138_abnormal_hepatobiliary_system0.69022706
163MP0005360_urolithiasis0.68844701
164MP0000026_abnormal_inner_ear0.68171444
165MP0003183_abnormal_peptide_metabolism0.68067281
166MP0010329_abnormal_lipoprotein_level0.67031309
167MP0000367_abnormal_coat/_hair0.66989238
168MP0004019_abnormal_vitamin_homeostasis0.66325997
169MP0004185_abnormal_adipocyte_glucose0.65901343
170MP0003828_pulmonary_edema0.65749783
171MP0002429_abnormal_blood_cell0.65029199
172MP0002938_white_spotting0.63809413
173MP0003699_abnormal_female_reproductive0.63775045
174MP0000313_abnormal_cell_death0.63618856
175MP0000467_abnormal_esophagus_morphology0.63583239
176MP0005085_abnormal_gallbladder_physiolo0.63478643
177MP0003861_abnormal_nervous_system0.63393934
178MP0003879_abnormal_hair_cell0.63328628
179MP0002396_abnormal_hematopoietic_system0.63221624
180MP0001663_abnormal_digestive_system0.62106619

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)6.30056340
2Dynein arm defect of respiratory motile cilia (HP:0012255)6.30056340
3Facial hemangioma (HP:0000329)6.22345134
4Rib fusion (HP:0000902)5.71204799
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.68259151
6Abnormal ciliary motility (HP:0012262)5.48374881
7Abnormal respiratory motile cilium physiology (HP:0012261)5.31808142
8Concave nail (HP:0001598)5.04275031
9Annular pancreas (HP:0001734)4.66265891
10Rectovaginal fistula (HP:0000143)4.56222588
11Rectal fistula (HP:0100590)4.56222588
12Pustule (HP:0200039)4.43856299
13Rhinitis (HP:0012384)4.29278849
14Turricephaly (HP:0000262)4.26726545
15Intestinal fistula (HP:0100819)4.23720406
16Increased IgM level (HP:0003496)4.18963193
17Poikiloderma (HP:0001029)4.15401772
18Alopecia of scalp (HP:0002293)4.13172854
19Hypochromic microcytic anemia (HP:0004840)4.10140594
20Male infertility (HP:0003251)4.06651431
21Vaginal fistula (HP:0004320)3.96975684
22Abnormality of the aortic arch (HP:0012303)3.95204782
23Alacrima (HP:0000522)3.89092305
24Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.78238954
25Ulnar bowing (HP:0003031)3.67959223
26Intestinal atresia (HP:0011100)3.66163504
27Coronal craniosynostosis (HP:0004440)3.62969435
28Nasal polyposis (HP:0100582)3.59685695
29Bronchiectasis (HP:0002110)3.59281369
30Orthostatic hypotension (HP:0001278)3.58226278
31Short humerus (HP:0005792)3.57896491
32Tongue fasciculations (HP:0001308)3.56084258
33Chronic hepatic failure (HP:0100626)3.49653134
34Nephronophthisis (HP:0000090)3.48247082
35Aplasia/hypoplasia of the humerus (HP:0006507)3.40459785
36Attenuation of retinal blood vessels (HP:0007843)3.39099963
37Abnormality of the labia minora (HP:0012880)3.35465143
38Abnormality of male internal genitalia (HP:0000022)3.31387346
39Pancreatic cysts (HP:0001737)3.28471607
40Molar tooth sign on MRI (HP:0002419)3.25474925
41Abnormality of midbrain morphology (HP:0002418)3.25474925
42Short chin (HP:0000331)3.23549653
43Muscle fibrillation (HP:0010546)3.21594092
44Cystic liver disease (HP:0006706)3.21128955
45Decreased lacrimation (HP:0000633)3.18890638
46Chronic bronchitis (HP:0004469)3.10752445
47Broad alveolar ridges (HP:0000187)3.10209753
48Abnormal respiratory motile cilium morphology (HP:0005938)3.09346042
49Abnormal respiratory epithelium morphology (HP:0012253)3.09346042
50Anteriorly placed anus (HP:0001545)3.06813720
51Absent radius (HP:0003974)3.01247275
52Pancreatic fibrosis (HP:0100732)2.97745776
53Absent thumb (HP:0009777)2.97588338
54Abnormality of the renal medulla (HP:0100957)2.95836362
55True hermaphroditism (HP:0010459)2.94128233
56Congenital stationary night blindness (HP:0007642)2.92474103
57Congenital hip dislocation (HP:0001374)2.91327142
58Mesangial abnormality (HP:0001966)2.91041076
59Choanal stenosis (HP:0000452)2.89832618
60Tubular atrophy (HP:0000092)2.89476384
61Genetic anticipation (HP:0003743)2.89009267
62Polydipsia (HP:0001959)2.86651578
63Abnormal drinking behavior (HP:0030082)2.86651578
64Absent forearm bone (HP:0003953)2.83043699
65Aplasia involving forearm bones (HP:0009822)2.83043699
66Capillary hemangiomas (HP:0005306)2.82899600
67Patellar aplasia (HP:0006443)2.82630372
68Abnormality of the nasal mucosa (HP:0000433)2.81775363
69Abnormality of the fingertips (HP:0001211)2.78391098
70Vertebral hypoplasia (HP:0008417)2.78035387
71Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.78035387
72Squamous cell carcinoma (HP:0002860)2.77594162
73Abnormal hemoglobin (HP:0011902)2.74859847
74Pancreatic islet-cell hyperplasia (HP:0004510)2.73471591
75Volvulus (HP:0002580)2.73092488
76Dysautonomia (HP:0002459)2.71389687
77Hamartoma (HP:0010566)2.70286942
78Hypotelorism (HP:0000601)2.69535397
79Diaphragmatic weakness (HP:0009113)2.68531189
80Thin bony cortex (HP:0002753)2.66293437
81Testicular atrophy (HP:0000029)2.63900043
82Premature skin wrinkling (HP:0100678)2.62171665
83Bony spicule pigmentary retinopathy (HP:0007737)2.61991946
84Large for gestational age (HP:0001520)2.60335542
85Mucopolysacchariduria (HP:0008155)2.59310267
86Urinary glycosaminoglycan excretion (HP:0003541)2.59310267
87Aplasia/Hypoplasia of the patella (HP:0006498)2.56321859
88Congenital hepatic fibrosis (HP:0002612)2.55694521
89Decreased central vision (HP:0007663)2.55429443
90Albinism (HP:0001022)2.54965379
91Dysostosis multiplex (HP:0000943)2.54160278
92Selective tooth agenesis (HP:0001592)2.54112460
93Decreased circulating renin level (HP:0003351)2.54066910
94Occipital encephalocele (HP:0002085)2.48137415
95Recurrent sinusitis (HP:0011108)2.41775557
96Basal cell carcinoma (HP:0002671)2.38496333
97Abnormality of mucopolysaccharide metabolism (HP:0011020)2.38084532
98Abnormality of polysaccharide metabolism (HP:0011012)2.38084532
99Abnormality of glycosaminoglycan metabolism (HP:0004371)2.38084532
100Acute lymphatic leukemia (HP:0006721)2.36688662
101Growth hormone excess (HP:0000845)2.35077828
102Hypotrichosis (HP:0001006)2.32409960
103Bifid uvula (HP:0000193)2.30491690
104Hypochromic anemia (HP:0001931)2.29562450
105Atelectasis (HP:0100750)2.28907993
106Abnormality of the astrocytes (HP:0100707)2.27794765
107Astrocytoma (HP:0009592)2.27794765
108Clumsiness (HP:0002312)2.25333615
109Broad face (HP:0000283)2.24158749
110Premature graying of hair (HP:0002216)2.23776787
111Joint stiffness (HP:0001387)2.21627122
112Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.19318843
113Obstructive sleep apnea (HP:0002870)2.17347198
114Aplasia of the musculature (HP:0100854)2.17272514
115Dyschromatopsia (HP:0007641)2.16754387
116Recurrent otitis media (HP:0000403)2.16255656
117Median cleft lip (HP:0000161)2.12481741
118Infertility (HP:0000789)2.12141965
119Narrow nasal bridge (HP:0000446)2.09690532
120Popliteal pterygium (HP:0009756)2.06722668
121Increased number of teeth (HP:0011069)2.05966308
122Bronchitis (HP:0012387)2.05036396
123Tubulointerstitial nephritis (HP:0001970)2.03507003
124Abnormality of the lower motor neuron (HP:0002366)2.02417345
125Hypoplasia of the radius (HP:0002984)2.01546611
126Polyuria (HP:0000103)2.01462017
127Postaxial foot polydactyly (HP:0001830)2.00898833
128Chronic sinusitis (HP:0011109)2.00773278
129Abnormality of the renal cortex (HP:0011035)2.00663729
130Hemorrhage of the eye (HP:0011885)2.00612529
131Polycythemia (HP:0001901)2.00212411
132Abnormal number of incisors (HP:0011064)2.00070878
133Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.99823832
134Bowing of the arm (HP:0006488)1.99213241
135Bowed forearm bones (HP:0003956)1.99213241
136Cerebral aneurysm (HP:0004944)1.98537589
137Gastrointestinal atresia (HP:0002589)1.98506879
138Vertebral fusion (HP:0002948)1.96655681
139Protruding tongue (HP:0010808)1.95530249
140Chronic otitis media (HP:0000389)1.95367163
141Spinal muscular atrophy (HP:0007269)1.93319720
142Amelogenesis imperfecta (HP:0000705)1.93166833
143Tented upper lip vermilion (HP:0010804)1.92354720
144Hypokinesia (HP:0002375)1.90170048
145Short 1st metacarpal (HP:0010034)1.88665265
146Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.88665265
147Short thumb (HP:0009778)1.88634486
148Cerebellar dysplasia (HP:0007033)1.88434215
149Stage 5 chronic kidney disease (HP:0003774)1.88345142
150Increased neuronal autofluorescent lipopigment (HP:0002074)1.87237750
151Split hand (HP:0001171)1.87082931
152Hypoalbuminemia (HP:0003073)1.86407991
153Abnormal albumin level (HP:0012116)1.86407991
154Type II lissencephaly (HP:0007260)1.85610957
155Severe visual impairment (HP:0001141)1.84875384
156Neoplasm of the oral cavity (HP:0100649)1.83869699
157Abnormality of the ileum (HP:0001549)1.83765562
158Macular degeneration (HP:0000608)1.83189443
159Broad hallux (HP:0010055)1.82526617
160Optic nerve coloboma (HP:0000588)1.79147994
161Recurrent cutaneous fungal infections (HP:0011370)1.74968521
162Chronic mucocutaneous candidiasis (HP:0002728)1.74968521
163Lip pit (HP:0100267)1.73582403
164Bell-shaped thorax (HP:0001591)1.73189462
165Elevated erythrocyte sedimentation rate (HP:0003565)1.70291895
166Abnormal rod and cone electroretinograms (HP:0008323)1.70214457
167Absent speech (HP:0001344)1.69744596
168Stridor (HP:0010307)1.67707228
169Facial diplegia (HP:0001349)1.67403906
170Hyperventilation (HP:0002883)1.66255852
171Decreased electroretinogram (ERG) amplitude (HP:0000654)1.65083324
172Enlarged epiphyses (HP:0010580)1.61305021
173Self-mutilation (HP:0000742)1.60762217
174Stomach cancer (HP:0012126)1.60016512
175Progressive cerebellar ataxia (HP:0002073)1.59344152
176Abnormal urine output (HP:0012590)1.58558442
177Aplasia/Hypoplasia of the spleen (HP:0010451)1.58205641
178Abnormality of the hepatic vasculature (HP:0006707)1.58168967
179Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.57532607
180Neonatal respiratory distress (HP:0002643)1.57001143
181Abnormality of the radial head (HP:0003995)1.55872181

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.13151592
2MAPK155.29411773
3DDR24.93293893
4MAP3K64.56755875
5PINK13.41183383
6MAP3K112.97507094
7TYRO32.91787613
8FGR2.79237147
9WNK42.72975823
10MATK2.63815685
11DAPK12.60728747
12FRK2.59162397
13UHMK12.38917645
14PIM22.29641137
15YES12.23699869
16PRKD22.19623828
17DYRK1B2.18462878
18BMX2.10850149
19TAOK31.95810671
20AKT31.92142621
21CDK71.84278894
22CSK1.83426980
23EEF2K1.78768246
24TLK11.77947589
25PDGFRA1.75809938
26MAP4K11.62883381
27MAP2K61.58681750
28GRK61.51474247
29MAP3K71.49697540
30TXK1.49245705
31CDK61.46828605
32MAP2K31.45730251
33TRPM71.44236961
34BLK1.38053341
35ZAP701.37277621
36ADRBK21.33525324
37PIM11.30439953
38MAPKAPK31.27036626
39MAP3K101.25786201
40CHEK21.22922342
41DYRK31.22750507
42LATS21.22513547
43CDC42BPA1.21152834
44CAMKK11.20862968
45RPS6KC11.19433075
46RPS6KL11.19433075
47MUSK1.18702104
48PKN21.16112712
49ERN11.13852066
50KIT1.12801808
51INSRR1.11755462
52BMPR1B1.10195111
53CAMK1D1.09447492
54PHKG21.09237140
55PHKG11.09237140
56MAP2K21.06081319
57WNK11.04797263
58RPS6KA61.03150493
59GSK3A1.02584108
60PLK11.01413257
61CDK121.01306221
62MAPK111.01163519
63FES0.99707832
64RPS6KA20.99634109
65DAPK20.97446304
66IKBKB0.96572909
67CHUK0.95994193
68PTK2B0.95584693
69BTK0.94076970
70EPHA20.93659648
71JAK30.90548700
72ACVR1B0.89720698
73IKBKE0.86553677
74TBK10.83345072
75PRPF4B0.79246943
76PDPK10.79034888
77MTOR0.78799228
78ATR0.78717175
79CAMK1G0.77738404
80MST1R0.77702822
81NEK20.75211679
82ADRBK10.74736800
83PRKAA10.74532874
84TAOK20.74001816
85ITK0.73776654
86PRKCH0.71764082
87SYK0.70354629
88GRK10.70274477
89MARK30.70190077
90HIPK20.69490255
91IRAK40.67479703
92ERBB20.66629759
93PTK60.65658659
94CSF1R0.64952870
95CDC70.64742539
96STK110.63544334
97TYK20.63080330
98RPS6KA10.62773629
99EPHB10.61277147
100WEE10.61040339
101MAPK120.60759810
102RIPK40.60099456
103ERBB30.59845062
104CDK20.58833943
105EPHA30.58497890
106MAPK130.57392330
107MAP2K40.56668744
108PDK10.56213986
109LCK0.55882840
110SIK20.55728579
111FLT30.54906133
112ZAK0.54768243
113HCK0.53182434
114IRAK10.53091754
115CAMKK20.52341406
116STK30.51029965
117MAPK80.49999449
118LATS10.49026016
119CAMK10.48983873
120STK390.48768288
121RAF10.47967942
122MAP3K140.47699719
123CAMK40.45931168
124CAMK2B0.45916368
125AURKA0.45855035
126PRKCQ0.45540023
127FGFR20.45521867
128RPS6KB10.45324481
129CHEK10.43697265
130CSNK2A10.42544476
131TAOK10.42005816
132CSNK1G10.41663233
133RPS6KB20.38902215
134CAMK2G0.38447970
135ATM0.37974059
136DYRK20.37912037
137BUB10.37457199
138MAPK100.37321638
139CDK10.37043163
140MAPK140.36751426
141CDK40.35199155
142MAPK10.35107037
143EGFR0.34191378
144NEK10.34161862
145MAPK30.32053416
146PRKD30.32047597
147TNK20.32020856
148MAPK40.31322424
149PRKAA20.30165749
150STK380.29652653
151CSNK2A20.29314763
152AURKB0.28826010
153PDGFRB0.27682992
154TTK0.27167943
155SGK10.27086752
156LYN0.26711130
157GSK3B0.24610254
158PRKCZ0.22589847
159CAMK2D0.21931121
160PRKCI0.21612711
161RPS6KA30.21011338
162CAMK2A0.21004179
163TRIB30.20362559
164PTK20.19863924
165SIK10.19849124
166PAK20.19364473
167AKT20.19336687
168MARK20.18833634
169AKT10.17630859
170ALK0.17401839
171STK38L0.16972300
172MAP3K90.16841135

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000615.54242243
2Mismatch repair_Homo sapiens_hsa034305.14513761
3Base excision repair_Homo sapiens_hsa034104.81092276
4DNA replication_Homo sapiens_hsa030304.06153618
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.90388274
6Nucleotide excision repair_Homo sapiens_hsa034202.51976648
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.42728079
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.35282096
9Spliceosome_Homo sapiens_hsa030402.28320464
10ABC transporters_Homo sapiens_hsa020102.25785693
11Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.22876715
12RNA transport_Homo sapiens_hsa030132.22415160
13Fanconi anemia pathway_Homo sapiens_hsa034602.21512730
14Other glycan degradation_Homo sapiens_hsa005112.17240064
15Circadian rhythm_Homo sapiens_hsa047102.16664607
16Homologous recombination_Homo sapiens_hsa034402.12715824
17mRNA surveillance pathway_Homo sapiens_hsa030152.09424971
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.07874497
19Hedgehog signaling pathway_Homo sapiens_hsa043402.06330101
20mTOR signaling pathway_Homo sapiens_hsa041502.03100516
21Notch signaling pathway_Homo sapiens_hsa043301.93004330
22Linoleic acid metabolism_Homo sapiens_hsa005911.80926379
23Hippo signaling pathway_Homo sapiens_hsa043901.75047555
24Biosynthesis of amino acids_Homo sapiens_hsa012301.74261226
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.70529732
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.64601327
27Arginine and proline metabolism_Homo sapiens_hsa003301.64343411
28Cell cycle_Homo sapiens_hsa041101.64332101
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.61044429
30Longevity regulating pathway - mammal_Homo sapiens_hsa042111.56576524
31p53 signaling pathway_Homo sapiens_hsa041151.53584293
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.39107389
33Sulfur relay system_Homo sapiens_hsa041221.35917849
34Lysine degradation_Homo sapiens_hsa003101.31500994
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31461799
36Taste transduction_Homo sapiens_hsa047421.30600176
37Fatty acid metabolism_Homo sapiens_hsa012121.29400550
38Adherens junction_Homo sapiens_hsa045201.28735038
39Basal cell carcinoma_Homo sapiens_hsa052171.28117563
40Intestinal immune network for IgA production_Homo sapiens_hsa046721.27812170
41Glycerophospholipid metabolism_Homo sapiens_hsa005641.25761822
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.22159398
43Oocyte meiosis_Homo sapiens_hsa041141.21559807
44Fructose and mannose metabolism_Homo sapiens_hsa000511.20307710
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.19579119
46Chemical carcinogenesis_Homo sapiens_hsa052041.19286093
47Wnt signaling pathway_Homo sapiens_hsa043101.16307950
48Ovarian steroidogenesis_Homo sapiens_hsa049131.16056686
49Transcriptional misregulation in cancer_Homo sapiens_hsa052021.12752371
50Sphingolipid metabolism_Homo sapiens_hsa006001.11180933
51T cell receptor signaling pathway_Homo sapiens_hsa046601.09155968
52TGF-beta signaling pathway_Homo sapiens_hsa043501.08896925
53NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07744226
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07632835
55Bladder cancer_Homo sapiens_hsa052191.06788011
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.05551588
57Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04519454
58Histidine metabolism_Homo sapiens_hsa003401.02967216
59Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02810769
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.02214706
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.02125394
62Folate biosynthesis_Homo sapiens_hsa007900.97464264
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.94085875
64TNF signaling pathway_Homo sapiens_hsa046680.92927770
65Inositol phosphate metabolism_Homo sapiens_hsa005620.92086399
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.91954574
67Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91033121
68Calcium signaling pathway_Homo sapiens_hsa040200.88348058
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86582081
70Salivary secretion_Homo sapiens_hsa049700.85124325
71Nitrogen metabolism_Homo sapiens_hsa009100.84656238
72Ether lipid metabolism_Homo sapiens_hsa005650.84137789
73Glycerolipid metabolism_Homo sapiens_hsa005610.83714441
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83136758
75Hematopoietic cell lineage_Homo sapiens_hsa046400.82331263
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.81935128
77Dorso-ventral axis formation_Homo sapiens_hsa043200.81428525
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.81208784
79Osteoclast differentiation_Homo sapiens_hsa043800.79063470
80Insulin resistance_Homo sapiens_hsa049310.78603106
81B cell receptor signaling pathway_Homo sapiens_hsa046620.77062388
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.76897002
83Colorectal cancer_Homo sapiens_hsa052100.75690163
84Arachidonic acid metabolism_Homo sapiens_hsa005900.75003140
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72854909
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72826234
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.72625024
88Hepatitis C_Homo sapiens_hsa051600.72530241
89One carbon pool by folate_Homo sapiens_hsa006700.71249602
90Graft-versus-host disease_Homo sapiens_hsa053320.70799340
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70498844
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.69404974
93VEGF signaling pathway_Homo sapiens_hsa043700.69391005
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.68314958
95Nicotine addiction_Homo sapiens_hsa050330.68041656
96Platelet activation_Homo sapiens_hsa046110.67850501
97Arginine biosynthesis_Homo sapiens_hsa002200.66894705
98Lysosome_Homo sapiens_hsa041420.66134739
99Morphine addiction_Homo sapiens_hsa050320.65856751
100AMPK signaling pathway_Homo sapiens_hsa041520.65815254
101Shigellosis_Homo sapiens_hsa051310.65399270
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64593241
103Caffeine metabolism_Homo sapiens_hsa002320.64497978
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.62794437
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.62279516
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.61681486
107MicroRNAs in cancer_Homo sapiens_hsa052060.61541925
108ErbB signaling pathway_Homo sapiens_hsa040120.59749312
109GnRH signaling pathway_Homo sapiens_hsa049120.59099957
110Vitamin digestion and absorption_Homo sapiens_hsa049770.58493839
111Insulin signaling pathway_Homo sapiens_hsa049100.58319365
112Cholinergic synapse_Homo sapiens_hsa047250.58144507
113Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58071318
114Circadian entrainment_Homo sapiens_hsa047130.57011411
115RNA polymerase_Homo sapiens_hsa030200.56866706
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56820926
117Gap junction_Homo sapiens_hsa045400.56405313
118Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55910119
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55476834
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55242608
121Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.55064643
122Choline metabolism in cancer_Homo sapiens_hsa052310.54806066
123Glutamatergic synapse_Homo sapiens_hsa047240.54329067
124Non-small cell lung cancer_Homo sapiens_hsa052230.52191297
125Type II diabetes mellitus_Homo sapiens_hsa049300.51896620
126Chemokine signaling pathway_Homo sapiens_hsa040620.51597622
127RNA degradation_Homo sapiens_hsa030180.50560935
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50116444
129Prolactin signaling pathway_Homo sapiens_hsa049170.49962358
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49787987
131Pyrimidine metabolism_Homo sapiens_hsa002400.49207551
132Olfactory transduction_Homo sapiens_hsa047400.49026001
133Basal transcription factors_Homo sapiens_hsa030220.47274028
134Autoimmune thyroid disease_Homo sapiens_hsa053200.46665122
135Galactose metabolism_Homo sapiens_hsa000520.46505945
136Regulation of autophagy_Homo sapiens_hsa041400.46122915
137Influenza A_Homo sapiens_hsa051640.45761611
138FoxO signaling pathway_Homo sapiens_hsa040680.44892181
139Viral carcinogenesis_Homo sapiens_hsa052030.44646902
140Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44352947
141Oxytocin signaling pathway_Homo sapiens_hsa049210.43301722
142Tight junction_Homo sapiens_hsa045300.41840735
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41256774
144Glutathione metabolism_Homo sapiens_hsa004800.41034654
145Cysteine and methionine metabolism_Homo sapiens_hsa002700.37832170
146Chronic myeloid leukemia_Homo sapiens_hsa052200.37205741
147Small cell lung cancer_Homo sapiens_hsa052220.36744763
148Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.36632166
149Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.35986234
150Glucagon signaling pathway_Homo sapiens_hsa049220.35016132
151Acute myeloid leukemia_Homo sapiens_hsa052210.31380018
152Central carbon metabolism in cancer_Homo sapiens_hsa052300.29204026
153Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28912534
154Epstein-Barr virus infection_Homo sapiens_hsa051690.28702610
155Endometrial cancer_Homo sapiens_hsa052130.27870570
156Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27600212
157MAPK signaling pathway_Homo sapiens_hsa040100.25024137
158HTLV-I infection_Homo sapiens_hsa051660.23223715
159Mineral absorption_Homo sapiens_hsa049780.21772398
160Viral myocarditis_Homo sapiens_hsa054160.20741381
161Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20394659
162Vitamin B6 metabolism_Homo sapiens_hsa007500.19759413
163Primary immunodeficiency_Homo sapiens_hsa053400.18233814
164Prostate cancer_Homo sapiens_hsa052150.17091652
165Legionellosis_Homo sapiens_hsa051340.16801512
166Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.16205725
167Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15833744
168Herpes simplex infection_Homo sapiens_hsa051680.15306645
169PI3K-Akt signaling pathway_Homo sapiens_hsa041510.14604428
170Proteoglycans in cancer_Homo sapiens_hsa052050.14413713
171Thyroid cancer_Homo sapiens_hsa052160.13866269
172Phototransduction_Homo sapiens_hsa047440.13782208
173Estrogen signaling pathway_Homo sapiens_hsa049150.12083807
174Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.12074957
175Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.11621862
176Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.11325211

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