CCDC54

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)9.98565706
2reproduction (GO:0000003)9.93197029
3response to pheromone (GO:0019236)9.85519757
4spermatid development (GO:0007286)9.71495044
5motile cilium assembly (GO:0044458)9.16008148
6regulation of cilium movement (GO:0003352)8.56205725
7cilium movement (GO:0003341)8.35596091
8single fertilization (GO:0007338)7.83449621
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.71180698
10sperm capacitation (GO:0048240)7.42880014
11male meiosis (GO:0007140)7.28593262
12synaptonemal complex organization (GO:0070193)7.10516983
13piRNA metabolic process (GO:0034587)7.02165338
14synaptonemal complex assembly (GO:0007130)6.95020970
15rRNA methylation (GO:0031167)6.94112919
16protein targeting to Golgi (GO:0000042)6.64601404
17negative regulation of inclusion body assembly (GO:0090084)6.56063819
18fertilization (GO:0009566)6.53891423
19spermatogenesis (GO:0007283)6.52189473
20male gamete generation (GO:0048232)6.49818826
21establishment of protein localization to Golgi (GO:0072600)6.38465784
22microtubule depolymerization (GO:0007019)6.28385919
23organic cation transport (GO:0015695)6.21350002
24retrograde transport, vesicle recycling within Golgi (GO:0000301)6.19579734
25phosphatidylethanolamine biosynthetic process (GO:0006646)6.06372507
26gamete generation (GO:0007276)5.97382479
27rRNA modification (GO:0000154)5.84019873
28phosphatidylethanolamine metabolic process (GO:0046337)5.58829463
29centriole replication (GO:0007099)5.56636014
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.53960528
31regulation of inclusion body assembly (GO:0090083)5.53763570
32cellular ketone body metabolic process (GO:0046950)5.52436891
33calcium ion-dependent exocytosis (GO:0017156)5.47449622
34cellular process involved in reproduction in multicellular organism (GO:0022412)5.43270883
35ventricular system development (GO:0021591)5.42809434
36germ cell development (GO:0007281)5.40408016
37regulation of Rab GTPase activity (GO:0032313)5.22162896
38positive regulation of Rab GTPase activity (GO:0032851)5.22162896
39spermatid nucleus differentiation (GO:0007289)5.18765894
40cell recognition (GO:0008037)5.10390167
41regulation of microtubule-based movement (GO:0060632)5.05263511
42glycerol ether metabolic process (GO:0006662)4.89854924
43chromatin silencing (GO:0006342)4.89780272
44ketone body metabolic process (GO:1902224)4.87198299
45male meiosis I (GO:0007141)4.83425438
46chromosome organization involved in meiosis (GO:0070192)4.78093693
47protein localization to Golgi apparatus (GO:0034067)4.76787340
48multicellular organismal reproductive process (GO:0048609)4.71371519
49microtubule severing (GO:0051013)4.64868128
50regulation of transcription involved in cell fate commitment (GO:0060850)4.61131280
51regulation of centriole replication (GO:0046599)4.60882819
52RNA destabilization (GO:0050779)4.57558668
53seminiferous tubule development (GO:0072520)4.53240289
54ether metabolic process (GO:0018904)4.52791947
55DNA methylation involved in gamete generation (GO:0043046)4.52291088
56chromosome condensation (GO:0030261)4.50551737
57meiotic nuclear division (GO:0007126)4.28028401
58DNA packaging (GO:0006323)4.26767852
59left/right pattern formation (GO:0060972)4.15966355
60negative regulation of Rho protein signal transduction (GO:0035024)4.12653561
61sexual reproduction (GO:0019953)4.11137922
62coenzyme catabolic process (GO:0009109)4.10160570
63multicellular organismal movement (GO:0050879)3.93750886
64musculoskeletal movement (GO:0050881)3.93750886
65monoubiquitinated protein deubiquitination (GO:0035520)3.92041616
66single strand break repair (GO:0000012)3.91622041
67chaperone-mediated protein complex assembly (GO:0051131)3.87549570
68meiosis I (GO:0007127)3.85071136
69genitalia morphogenesis (GO:0035112)3.81116276
70multicellular organismal development (GO:0007275)3.78141061
71glomerular visceral epithelial cell development (GO:0072015)3.57293933
72protein polyglutamylation (GO:0018095)3.55935769
73cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.52547864
74histone H3-K9 demethylation (GO:0033169)3.44771299
75sequestering of actin monomers (GO:0042989)3.44338771
76glomerular epithelial cell development (GO:0072310)3.44293986
77protein K11-linked deubiquitination (GO:0035871)3.44268288
78negative regulation of gene expression, epigenetic (GO:0045814)3.36387289
79regulation of somitogenesis (GO:0014807)3.34177113
80meiotic cell cycle (GO:0051321)3.29775333
81nucleosome disassembly (GO:0006337)3.27145364
82protein-DNA complex disassembly (GO:0032986)3.27145364
83cerebral cortex neuron differentiation (GO:0021895)3.24830996
84protein localization to cilium (GO:0061512)3.24422054
85regulation of interleukin-13 production (GO:0032656)3.22536973
86microtubule polymerization or depolymerization (GO:0031109)3.22339506
87protein refolding (GO:0042026)3.21507115
88glycolytic process (GO:0006096)3.20658654
89protein depolymerization (GO:0051261)3.20527662
90response to acidic pH (GO:0010447)3.19011373
91peptidyl-threonine dephosphorylation (GO:0035970)3.18338538
92microtubule nucleation (GO:0007020)3.16698986
93regulation of T-helper 2 cell differentiation (GO:0045628)3.15549355
94mesenchymal cell differentiation involved in renal system development (GO:2001012)3.15501001
95mesenchymal cell differentiation involved in kidney development (GO:0072161)3.15501001
96regulation of spindle checkpoint (GO:0090231)3.09601203
97cranial nerve morphogenesis (GO:0021602)3.08144445
98amino-acid betaine transport (GO:0015838)3.07057069
99carnitine transport (GO:0015879)3.07057069
100membrane protein intracellular domain proteolysis (GO:0031293)3.04840769
101nucleoside diphosphate phosphorylation (GO:0006165)3.04837976
102nucleus organization (GO:0006997)3.04798510
103cellular response to pH (GO:0071467)3.03941163
104homeostasis of number of cells within a tissue (GO:0048873)3.03936796
105DNA conformation change (GO:0071103)3.01650679
106polyol catabolic process (GO:0046174)3.01526028
107cell differentiation involved in metanephros development (GO:0072202)3.01109444
108lactate metabolic process (GO:0006089)2.95663566
109NAD biosynthetic process (GO:0009435)2.95625973
110GTP biosynthetic process (GO:0006183)2.91589981
111carnitine transmembrane transport (GO:1902603)2.91550954
112alditol metabolic process (GO:0019400)2.91443162
113cilium organization (GO:0044782)2.91307331
114microtubule-based movement (GO:0007018)2.88711033
115mitotic sister chromatid cohesion (GO:0007064)2.84854238
116intraciliary transport (GO:0042073)2.84335941
117synapsis (GO:0007129)2.83788954
118regulation of phosphoprotein phosphatase activity (GO:0043666)2.79391414
119cilium assembly (GO:0042384)2.78689138
120meiotic cell cycle process (GO:1903046)2.76742843
121positive regulation of skeletal muscle tissue development (GO:0048643)2.76350942
122cellular component assembly involved in morphogenesis (GO:0010927)2.76132088
123negative regulation of organelle assembly (GO:1902116)2.75645729
124negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.75032712
125positive regulation of macrophage activation (GO:0043032)2.73541147
126mitotic G1 DNA damage checkpoint (GO:0031571)2.73462767
127axoneme assembly (GO:0035082)2.70188651
128cilium morphogenesis (GO:0060271)2.66016664
129interferon-gamma secretion (GO:0072643)2.64408771
130centriole assembly (GO:0098534)2.63917518
131UTP biosynthetic process (GO:0006228)2.60358826
132RNA localization (GO:0006403)2.59605261
133nuclear pore complex assembly (GO:0051292)2.56865792
134gene silencing by RNA (GO:0031047)2.53123683
135regulation of cilium assembly (GO:1902017)2.46625100
136polyamine biosynthetic process (GO:0006596)2.44729319
137glycerol metabolic process (GO:0006071)2.44523102
138peptidyl-glutamic acid modification (GO:0018200)2.44339911
139fusion of sperm to egg plasma membrane (GO:0007342)14.2699214
140sperm motility (GO:0030317)14.0399489
141cell wall macromolecule catabolic process (GO:0016998)13.1499281
142cell wall macromolecule metabolic process (GO:0044036)13.1499281
143acrosome assembly (GO:0001675)11.9606388
144acrosome reaction (GO:0007340)11.8173565
145sperm-egg recognition (GO:0035036)11.7678752
146multicellular organism reproduction (GO:0032504)11.5949963
147plasma membrane fusion (GO:0045026)10.8789238
148binding of sperm to zona pellucida (GO:0007339)10.6267134
149cell-cell recognition (GO:0009988)10.5413460
150cilium or flagellum-dependent cell motility (GO:0001539)10.3386203
151epithelial cilium movement (GO:0003351)10.1931949

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.58455024
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.69979405
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.38987687
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.12489762
5EZH2_22144423_ChIP-Seq_EOC_Human4.00291075
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.72868855
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.34689337
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.09760923
9PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.81459218
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.51411296
11VDR_22108803_ChIP-Seq_LS180_Human2.28352190
12CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.22770541
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.22320256
14CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.19722102
15ELF1_20517297_ChIP-Seq_JURKAT_Human2.10878906
16EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.06802195
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.05311756
18VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.05094909
19ERA_21632823_ChIP-Seq_H3396_Human2.03003462
20ZNF274_21170338_ChIP-Seq_K562_Hela2.00021252
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95058938
22FUS_26573619_Chip-Seq_HEK293_Human1.94049323
23PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91271476
24GATA1_26923725_Chip-Seq_HPCs_Mouse1.89336896
25KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.88290538
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.86611192
27DROSHA_22980978_ChIP-Seq_HELA_Human1.86065984
28RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.82086155
29NANOG_20526341_ChIP-Seq_ESCs_Human1.81717555
30TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.80022564
31* RAC3_21632823_ChIP-Seq_H3396_Human1.79235907
32EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.79217829
33CTCF_27219007_Chip-Seq_Bcells_Human1.76159829
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.74744529
35STAT1_17558387_ChIP-Seq_HELA_Human1.72731668
36ELK4_26923725_Chip-Seq_MESODERM_Mouse1.68715784
37* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.65824899
38BCL6_27268052_Chip-Seq_Bcells_Human1.64737869
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.64736368
40MYC_19829295_ChIP-Seq_ESCs_Human1.62925487
41E2F1_20622854_ChIP-Seq_HELA_Human1.62568290
42GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.62554936
43MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.62381360
44TAF2_19829295_ChIP-Seq_ESCs_Human1.62283710
45TDRD3_21172665_ChIP-Seq_MCF-7_Human1.61751028
46FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60932605
47ER_23166858_ChIP-Seq_MCF-7_Human1.60673623
48SMC4_20622854_ChIP-Seq_HELA_Human1.58005464
49WDR5_24793694_ChIP-Seq_LNCAP_Human1.57194563
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.55180690
51SOX2_22085726_ChIP-Seq_NPCs_Mouse1.54164928
52KAP1_22055183_ChIP-Seq_ESCs_Mouse1.54058406
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.52820245
54TAL1_26923725_Chip-Seq_HPCs_Mouse1.52564374
55SMAD4_21741376_ChIP-Seq_EPCs_Human1.51525635
56CTCF_20526341_ChIP-Seq_ESCs_Human1.50263769
57BCOR_27268052_Chip-Seq_Bcells_Human1.49908117
58P68_20966046_ChIP-Seq_HELA_Human1.49898568
59TP53_18474530_ChIP-ChIP_U2OS_Human1.49871106
60PHF8_20622854_ChIP-Seq_HELA_Human1.49295652
61* KDM2B_26808549_Chip-Seq_REH_Human1.49277331
62GATA3_21867929_ChIP-Seq_CD8_Mouse1.47042862
63PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.46553775
64PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46514030
65ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.45196248
66OCT4_20526341_ChIP-Seq_ESCs_Human1.45185496
67* TP63_22573176_ChIP-Seq_HFKS_Human1.42951390
68ETV2_25802403_ChIP-Seq_MESCs_Mouse1.41832142
69NFE2_27457419_Chip-Seq_LIVER_Mouse1.41140993
70HNFA_21074721_ChIP-Seq_CACO-2_Human1.40759362
71AR_25329375_ChIP-Seq_VCAP_Human1.40072438
72CBX2_22325352_ChIP-Seq_293T-Rex_Human1.39901451
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36579585
74* CBP_20019798_ChIP-Seq_JUKART_Human1.36527257
75* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36527257
76LXR_22292898_ChIP-Seq_THP-1_Human1.35351084
77RBPJ_21746931_ChIP-Seq_IB4_Human1.35163111
78SUZ12_27294783_Chip-Seq_ESCs_Mouse1.34553847
79CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.34378153
80LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.33185116
81P300_27268052_Chip-Seq_Bcells_Human1.32478790
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32218804
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31371542
84SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.30810600
85ETV1_20927104_ChIP-Seq_GIST48_Human1.30767719
86FLI1_21867929_ChIP-Seq_TH2_Mouse1.30633721
87SMAD3_21741376_ChIP-Seq_ESCs_Human1.30602742
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.30448249
89GATA3_21867929_ChIP-Seq_TH1_Mouse1.29884010
90GATA3_21878914_ChIP-Seq_MCF-7_Human1.29630746
91PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.27928390
92P53_21459846_ChIP-Seq_SAOS-2_Human1.27470174
93CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27174745
94CEBPB_22108803_ChIP-Seq_LS180_Human1.26529774
95TP63_19390658_ChIP-ChIP_HaCaT_Human1.24920213
96REST_21632747_ChIP-Seq_MESCs_Mouse1.24687488
97TAF15_26573619_Chip-Seq_HEK293_Human1.24575736
98P300_19829295_ChIP-Seq_ESCs_Human1.24409491
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.22722388
100P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.21311504
101FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.20958454
102NANOG_18555785_Chip-Seq_ESCs_Mouse1.20573347
103TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20081051
104SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.19919125
105TBL1_22424771_ChIP-Seq_293T_Human1.19502652
106ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19094394
107CRX_20693478_ChIP-Seq_RETINA_Mouse1.19004313
108GF1_26923725_Chip-Seq_HPCs_Mouse1.18424464
109* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17862482
110RUNX_20019798_ChIP-Seq_JUKART_Human1.17740396
111TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16547949
112NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16232499
113ZFP57_27257070_Chip-Seq_ESCs_Mouse1.15502263
114SMAD4_21741376_ChIP-Seq_HESCs_Human1.15393796
115EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15198902
116SA1_27219007_Chip-Seq_Bcells_Human1.14371540
117SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.13708406
118KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13048513
119PHF8_20622853_ChIP-Seq_HELA_Human1.12530250
120EZH2_27294783_Chip-Seq_ESCs_Mouse1.12526822
121PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12230595
122RAD21_21589869_ChIP-Seq_MESCs_Mouse1.11461172
123* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10950087
124OCT4_18555785_Chip-Seq_ESCs_Mouse1.10675872
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.10457784
126GATA6_21074721_ChIP-Seq_CACO-2_Human1.10037780
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09687704
128P53_22387025_ChIP-Seq_ESCs_Mouse1.09313605
129CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08771900
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07935567
131RUNX1_26923725_Chip-Seq_HPCs_Mouse1.06886431
132CMYC_18555785_Chip-Seq_ESCs_Mouse1.06132270
133SPI1_26923725_Chip-Seq_HPCs_Mouse1.05742404
134RNF2_27304074_Chip-Seq_NSC_Mouse1.04333591
135EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.04242530
136NANOG_19829295_ChIP-Seq_ESCs_Human1.03871406
137SOX2_19829295_ChIP-Seq_ESCs_Human1.03871406
138HOXB7_26014856_ChIP-Seq_BT474_Human1.03362380
139PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.02944651
140P300_18555785_Chip-Seq_ESCs_Mouse1.01908155
141NFYA_21822215_ChIP-Seq_K562_Human1.01543160
142PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.01373207
143ESET_19884257_ChIP-Seq_ESCs_Mouse1.01228926
144SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01023552
145OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00332392
146GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.00259538
147* RUNX2_22187159_ChIP-Seq_PCA_Human0.99981858
148EZH2_27294783_Chip-Seq_NPCs_Mouse0.99755186
149* SMRT_27268052_Chip-Seq_Bcells_Human0.99318036
150KLF4_18555785_Chip-Seq_ESCs_Mouse0.98810018
151OCT1_27270436_Chip-Seq_PROSTATE_Human0.98514516
152E2F1_17053090_ChIP-ChIP_MCF-7_Human0.97629148
153KLF5_25053715_ChIP-Seq_YYC3_Human0.97131762
154* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96884208
155SOX9_26525672_Chip-Seq_HEART_Mouse0.96368541
156ESRRB_18555785_Chip-Seq_ESCs_Mouse0.96332793
157NFIB_24661679_ChIP-Seq_LUNG_Mouse0.94477155
158* POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93783097
159* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93783097
160EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93688957
161MYC_27129775_Chip-Seq_CORNEA_Mouse0.93548551
162RARA_24833708_ChIP-Seq_LIVER_Mouse0.93141768
163GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93040254
164SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92596220
165KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92325580
166* ERG_20517297_ChIP-Seq_VCAP_Human0.91985466
167SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91850706
168RXRA_24833708_ChIP-Seq_LIVER_Mouse0.91157654
169CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91066422
170NFYB_21822215_ChIP-Seq_K562_Human0.90959186
171YY1_22570637_ChIP-Seq_MALME-3M_Human0.90741466
172LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89995112
173STAT3_18555785_Chip-Seq_ESCs_Mouse0.88411294
174* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.88211057
175PU1_27457419_Chip-Seq_LIVER_Mouse0.87066249

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive6.14449748
2MP0001929_abnormal_gametogenesis5.55737706
3MP0008877_abnormal_DNA_methylation4.17263189
4MP0001348_abnormal_lacrimal_gland3.74101442
5MP0002210_abnormal_sex_determination3.43968167
6MP0002161_abnormal_fertility/fecundity3.33834556
7MP0001145_abnormal_male_reproductive2.92378316
8MP0000678_abnormal_parathyroid_gland2.76751363
9MP0005670_abnormal_white_adipose2.72986459
10MP0000653_abnormal_sex_gland2.53585460
11MP0002653_abnormal_ependyma_morphology2.50449899
12MP0003718_maternal_effect2.22178427
13MP0002132_abnormal_respiratory_system2.16113153
14MP0005410_abnormal_fertilization16.4746239
15MP0005379_endocrine/exocrine_gland_phen1.83948088
16MP0002249_abnormal_larynx_morphology1.72797582
17MP0005623_abnormal_meninges_morphology1.70206264
18MP0002160_abnormal_reproductive_system1.69131629
19MP0005423_abnormal_somatic_nervous1.68295515
20MP0004510_myositis1.62232851
21MP0001486_abnormal_startle_reflex1.52995967
22MP0001485_abnormal_pinna_reflex1.52821761
23MP0009053_abnormal_anal_canal1.45882534
24MP0005310_abnormal_salivary_gland1.40497972
25MP0003646_muscle_fatigue1.37652208
26MP0002282_abnormal_trachea_morphology1.34765622
27MP0004233_abnormal_muscle_weight1.30103549
28MP0005248_abnormal_Harderian_gland1.28290363
29MP0001765_abnormal_ion_homeostasis1.23215337
30MP0002127_abnormal_cardiovascular_syste1.19202338
31MP0002735_abnormal_chemical_nociception1.17984323
32MP0002822_catalepsy1.12324307
33MP0004859_abnormal_synaptic_plasticity1.09728361
34MP0001963_abnormal_hearing_physiology1.07780359
35MP0002138_abnormal_hepatobiliary_system1.03508057
36MP0005451_abnormal_body_composition1.02404870
37MP0005395_other_phenotype1.02300141
38MP0005647_abnormal_sex_gland1.01380537
39MP0000026_abnormal_inner_ear1.00070791
40MP0009046_muscle_twitch0.96660092
41MP0008058_abnormal_DNA_repair0.93693326
42MP0000681_abnormal_thyroid_gland0.93629913
43MP0001984_abnormal_olfaction0.92327832
44MP0008995_early_reproductive_senescence0.88861643
45MP0000955_abnormal_spinal_cord0.87860550
46MP0005389_reproductive_system_phenotype0.85720264
47MP0000049_abnormal_middle_ear0.81676824
48MP0004484_altered_response_of0.77010413
49MP0004085_abnormal_heartbeat0.76681249
50MP0001879_abnormal_lymphatic_vessel0.74916787
51MP0002733_abnormal_thermal_nociception0.72808240
52MP0005367_renal/urinary_system_phenotyp0.72375155
53MP0000516_abnormal_urinary_system0.72375155
54MP0002067_abnormal_sensory_capabilities0.71823169
55MP0003115_abnormal_respiratory_system0.68318066
56MP0003878_abnormal_ear_physiology0.67679698
57MP0005377_hearing/vestibular/ear_phenot0.67679698
58MP0005636_abnormal_mineral_homeostasis0.67198410
59MP0008569_lethality_at_weaning0.66605483
60MP0009697_abnormal_copulation0.64512996
61MP0000569_abnormal_digit_pigmentation0.64134523
62MP0003011_delayed_dark_adaptation0.63334017
63MP0005083_abnormal_biliary_tract0.62803141
64MP0005666_abnormal_adipose_tissue0.58774647
65MP0002234_abnormal_pharynx_morphology0.58599705
66MP0002557_abnormal_social/conspecific_i0.58565999
67MP0005167_abnormal_blood-brain_barrier0.57115647
68MP0010094_abnormal_chromosome_stability0.56359998
69MP0000003_abnormal_adipose_tissue0.55512873
70MP0003137_abnormal_impulse_conducting0.54703940
71MP0001324_abnormal_eye_pigmentation0.52721528
72MP0001666_abnormal_nutrient_absorption0.52381648
73MP0002572_abnormal_emotion/affect_behav0.51209193
74MP0000358_abnormal_cell_content/0.51110582
75MP0002928_abnormal_bile_duct0.50325948
76MP0004084_abnormal_cardiac_muscle0.50310413
77MP0004036_abnormal_muscle_relaxation0.49976317
78MP0003950_abnormal_plasma_membrane0.49866629
79MP0001905_abnormal_dopamine_level0.49600751
80MP0003119_abnormal_digestive_system0.49579759
81MP0003699_abnormal_female_reproductive0.49441394
82MP0001764_abnormal_homeostasis0.48764363
83MP0001970_abnormal_pain_threshold0.48093547
84MP0003077_abnormal_cell_cycle0.46759886
85MP0002734_abnormal_mechanical_nocicepti0.46667943
86MP0000249_abnormal_blood_vessel0.46632187
87MP0002272_abnormal_nervous_system0.46010440
88MP0001293_anophthalmia0.44284272
89MP0005397_hematopoietic_system_phenotyp0.43876773
90MP0001545_abnormal_hematopoietic_system0.43876773
91MP0005535_abnormal_body_temperature0.43836584
92MP0003329_amyloid_beta_deposits0.42521443
93MP0009278_abnormal_bone_marrow0.41779559
94MP0002269_muscular_atrophy0.41141954
95MP0000230_abnormal_systemic_arterial0.41063451
96MP0001501_abnormal_sleep_pattern0.40873928
97MP0008057_abnormal_DNA_replication0.40650334
98MP0001440_abnormal_grooming_behavior0.40550862
99MP0009745_abnormal_behavioral_response0.40393857
100MP0005253_abnormal_eye_physiology0.40184834
101MP0009115_abnormal_fat_cell0.39783916
102MP0005551_abnormal_eye_electrophysiolog0.39681143
103MP0000566_synostosis0.39021672
104MP0003786_premature_aging0.38028016
105MP0000470_abnormal_stomach_morphology0.37786168
106MP0000613_abnormal_salivary_gland0.37294720
107MP0003936_abnormal_reproductive_system0.36689985
108MP0006036_abnormal_mitochondrial_physio0.36195330
109MP0002971_abnormal_brown_adipose0.34971109
110MP0006292_abnormal_olfactory_placode0.34027410
111MP0002736_abnormal_nociception_after0.33376530
112MP0005408_hypopigmentation0.33103542
113MP0003880_abnormal_central_pattern0.33074832
114MP0004019_abnormal_vitamin_homeostasis0.31656030
115MP0002102_abnormal_ear_morphology0.31278960
116MP0001119_abnormal_female_reproductive0.31033772
117MP0005391_vision/eye_phenotype0.30972834
118MP0000749_muscle_degeneration0.30184450
119MP0003111_abnormal_nucleus_morphology0.29330670
120MP0000534_abnormal_ureter_morphology0.29312901
121MP0003633_abnormal_nervous_system0.29164120
122MP0002139_abnormal_hepatobiliary_system0.28720860
123MP0008007_abnormal_cellular_replicative0.28606169
124MP0004133_heterotaxia0.27089035
125MP0010307_abnormal_tumor_latency0.24129065
126MP0004811_abnormal_neuron_physiology0.23907245
127MP0001730_embryonic_growth_arrest0.22724758
128MP0003879_abnormal_hair_cell0.22608765
129MP0001727_abnormal_embryo_implantation0.22289999
130MP0003942_abnormal_urinary_system0.22284143
131MP0000604_amyloidosis0.21776403
132MP0003861_abnormal_nervous_system0.20662162
133MP0003631_nervous_system_phenotype0.20276332
134MP0006035_abnormal_mitochondrial_morpho0.20130858
135MP0003948_abnormal_gas_homeostasis0.20064247
136MP0008961_abnormal_basal_metabolism0.19769898
137MP0000751_myopathy0.19607569
138MP0002152_abnormal_brain_morphology0.19390677
139MP0004742_abnormal_vestibular_system0.19077900
140MP0002169_no_abnormal_phenotype0.18619250
141MP0002873_normal_phenotype0.18380449
142MP0005375_adipose_tissue_phenotype0.18009349
143MP0002295_abnormal_pulmonary_circulatio0.17242535
144MP0000313_abnormal_cell_death0.17085125
145MP0001968_abnormal_touch/_nociception0.16228328
146MP0002092_abnormal_eye_morphology0.16224200
147MP0001661_extended_life_span0.15038031
148MP0005319_abnormal_enzyme/_coenzyme0.14562882
149MP0004145_abnormal_muscle_electrophysio0.14550743
150MP0004808_abnormal_hematopoietic_stem0.14126155
151MP0002405_respiratory_system_inflammati0.13906047
152MP0002084_abnormal_developmental_patter0.13723459
153MP0003959_abnormal_lean_body0.13506087
154MP0004043_abnormal_pH_regulation0.13319933
155MP0004270_analgesia0.12939397
156MP0008875_abnormal_xenobiotic_pharmacok0.12925974
157MP0001849_ear_inflammation0.12784777
158MP0002229_neurodegeneration0.12602745
159MP0009672_abnormal_birth_weight0.12106536
160MP0002693_abnormal_pancreas_physiology0.12017119
161MP0005195_abnormal_posterior_eye0.11911690
162MP0000001_mammalian_phenotype0.11857497

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.43154962
2Abnormal respiratory epithelium morphology (HP:0012253)9.29547030
3Abnormal respiratory motile cilium morphology (HP:0005938)9.29547030
4Severe visual impairment (HP:0001141)8.31930233
5Abnormal ciliary motility (HP:0012262)7.70205541
6Rhinitis (HP:0012384)7.52640913
7Chronic bronchitis (HP:0004469)7.26401562
8Infertility (HP:0000789)6.70134559
9Nasal polyposis (HP:0100582)6.35146669
10Abnormality of the nasal mucosa (HP:0000433)5.22916266
11Attenuation of retinal blood vessels (HP:0007843)5.06885547
12Bony spicule pigmentary retinopathy (HP:0007737)4.95199627
13Male infertility (HP:0003251)4.79166225
14Bronchitis (HP:0012387)4.60321936
15Resting tremor (HP:0002322)4.59676848
16Bronchiectasis (HP:0002110)4.43832022
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.33605036
18Hypoplastic ischia (HP:0003175)4.31558433
19Nephronophthisis (HP:0000090)4.27675129
20Chronic hepatic failure (HP:0100626)4.22956900
21Hyperkalemia (HP:0002153)4.16276269
22Abnormal rod and cone electroretinograms (HP:0008323)3.95153531
23Abnormality of macular pigmentation (HP:0008002)3.92860530
24Abnormality of the ischium (HP:0003174)3.88451976
25Potter facies (HP:0002009)3.88238060
26Facial shape deformation (HP:0011334)3.88238060
27Enlarged epiphyses (HP:0010580)3.73166011
28Aplasia/Hypoplasia of the earlobes (HP:0009906)3.71103041
29Abnormal spermatogenesis (HP:0008669)3.66725522
30Cone-rod dystrophy (HP:0000548)3.61632923
31Recurrent sinusitis (HP:0011108)3.59038211
32Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.44684294
33Recurrent otitis media (HP:0000403)3.29168836
34Abnormality of the renal medulla (HP:0100957)3.24112102
35Unilateral renal agenesis (HP:0000122)3.18744518
36Hypoplasia of the thymus (HP:0000778)3.09121050
37Tubulointerstitial nephritis (HP:0001970)2.97565106
38Postural instability (HP:0002172)2.93211477
39Progressive sensorineural hearing impairment (HP:0000408)2.86951085
40Recurrent bronchitis (HP:0002837)2.82935519
41Abnormality of the aortic arch (HP:0012303)2.82679739
42Hypoalphalipoproteinemia (HP:0003233)2.77296522
43Generalized aminoaciduria (HP:0002909)2.68387893
44Abnormality of midbrain morphology (HP:0002418)2.67605510
45Molar tooth sign on MRI (HP:0002419)2.67605510
46Tubular atrophy (HP:0000092)2.67363510
47Ventricular tachycardia (HP:0004756)2.66271555
48Amelogenesis imperfecta (HP:0000705)2.63543483
49Progressive cerebellar ataxia (HP:0002073)2.57540870
50Medial flaring of the eyebrow (HP:0010747)2.50035101
51Abnormality of the costochondral junction (HP:0000919)2.49850172
52Tubulointerstitial abnormality (HP:0001969)2.49701297
53Abnormality of potassium homeostasis (HP:0011042)2.49462056
54Truncal obesity (HP:0001956)2.48062812
55Impulsivity (HP:0100710)2.47556742
56Abnormality of dental color (HP:0011073)2.41188330
57Abnormality of the parathyroid morphology (HP:0011766)2.36824386
58Azoospermia (HP:0000027)2.35215556
59Gonadotropin excess (HP:0000837)2.33079017
60Portal hypertension (HP:0001409)2.31759141
61Renovascular hypertension (HP:0100817)2.30638476
62Epiphyseal dysplasia (HP:0002656)2.30215714
63Muscle fiber atrophy (HP:0100295)2.24641583
64Insulin-resistant diabetes mellitus (HP:0000831)2.23562958
65Flattened epiphyses (HP:0003071)2.22246490
66Menstrual irregularities (HP:0000858)2.16983453
67Abnormal gallbladder physiology (HP:0012438)2.14490868
68Cholecystitis (HP:0001082)2.14490868
69Focal segmental glomerulosclerosis (HP:0000097)2.13175663
70Abnormality of the pubic bones (HP:0003172)2.12323917
71Abnormality of the hepatic vasculature (HP:0006707)2.10833071
72Osteomalacia (HP:0002749)2.09640671
73Dyschromatopsia (HP:0007641)2.09392457
74Fatigable weakness (HP:0003473)2.06650922
75Abnormality of the neuromuscular junction (HP:0003398)2.06650922
76Abnormality of the epiphysis of the femoral head (HP:0010574)2.05118535
77Hyponatremia (HP:0002902)2.01955024
78Dynein arm defect of respiratory motile cilia (HP:0012255)13.6264171
79Absent/shortened dynein arms (HP:0200106)13.6264171
80Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.2146135
81Tetany (HP:0001281)1.99816233
82Type 2 muscle fiber atrophy (HP:0003554)1.99676021
83Tubulointerstitial fibrosis (HP:0005576)1.97381053
84Spastic paraparesis (HP:0002313)1.93496339
85Bradycardia (HP:0001662)1.92915980
86Widely patent fontanelles and sutures (HP:0004492)1.92789017
87Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.92204928
88Abnormality of femoral epiphyses (HP:0006499)1.92204928
89Hypophosphatemic rickets (HP:0004912)1.91792606
90Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90725598
91Recurrent corneal erosions (HP:0000495)1.90049314
92Intellectual disability, moderate (HP:0002342)1.87238135
93Decreased central vision (HP:0007663)1.86149271
94Hyperthyroidism (HP:0000836)1.85680610
95Postaxial foot polydactyly (HP:0001830)1.84877119
96Abnormal ventriculo-arterial connection (HP:0011563)1.84119867
97Transposition of the great arteries (HP:0001669)1.84119867
98Abnormal connection of the cardiac segments (HP:0011545)1.84119867
99Flat capital femoral epiphysis (HP:0003370)1.83157293
100Abnormality of the femoral head (HP:0003368)1.82209245
101Stage 5 chronic kidney disease (HP:0003774)1.81931416
102Hypoplastic heart (HP:0001961)1.80802920
103Spastic tetraparesis (HP:0001285)1.79576171
104Polydipsia (HP:0001959)1.77963936
105Abnormal drinking behavior (HP:0030082)1.77963936
106Choroideremia (HP:0001139)1.74696466
107Abnormality of the renal cortex (HP:0011035)1.74007731
108Congenital hepatic fibrosis (HP:0002612)1.73870833
109Heterotopia (HP:0002282)1.72277288
110Abnormality of the lower motor neuron (HP:0002366)1.70840612
111Abnormality of renal excretion (HP:0011036)1.68056594
112Asymmetric septal hypertrophy (HP:0001670)1.64486938
113Abnormal biliary tract physiology (HP:0012439)1.63916274
114Bile duct proliferation (HP:0001408)1.63916274
115Short ribs (HP:0000773)1.60801343
116Fibular hypoplasia (HP:0003038)1.60012197
117Oculomotor apraxia (HP:0000657)1.58375301
118Abnormality of permanent molar morphology (HP:0011071)1.57961782
119Abnormality of the dental root (HP:0006486)1.57961782
120Taurodontia (HP:0000679)1.57961782
121Hypoplasia of the capital femoral epiphysis (HP:0003090)1.55131965
122Bell-shaped thorax (HP:0001591)1.54822798
123Hemorrhage of the eye (HP:0011885)1.51739518
124Abnormality of molar (HP:0011077)1.48135753
125Abnormality of molar morphology (HP:0011070)1.48135753
126Absent frontal sinuses (HP:0002688)1.46375886
127Chronic sinusitis (HP:0011109)1.45187503
128Postaxial hand polydactyly (HP:0001162)1.45094321
129Microglossia (HP:0000171)1.44929909
130Abnormality of the dental pulp (HP:0006479)1.44866942
131Abnormality of dentin (HP:0010299)1.44016785
132Renal dysplasia (HP:0000110)1.40975469
133Amyotrophic lateral sclerosis (HP:0007354)1.40963016
134Cystic liver disease (HP:0006706)1.39895327
135Aplasia/Hypoplasia of the lens (HP:0008063)1.36404351
136J-shaped sella turcica (HP:0002680)1.36401186
137Pancreatic fibrosis (HP:0100732)1.35917753
138Deformed sella turcica (HP:0002681)1.34527340
139Abnormal urine output (HP:0012590)1.34330123
140Facial cleft (HP:0002006)1.33823301
141Bundle branch block (HP:0011710)1.33362637
142Decreased electroretinogram (ERG) amplitude (HP:0000654)1.31202952
143Congenital primary aphakia (HP:0007707)1.30949465
144Gait imbalance (HP:0002141)1.30507375
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.29077211
146Neurofibrillary tangles (HP:0002185)1.24906440
147Abnormality of saccadic eye movements (HP:0000570)1.23100859
148Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.22297455
149Constricted visual fields (HP:0001133)1.21797043
150Absent epiphyses (HP:0010577)1.21255614
151Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.21255614
152Impaired proprioception (HP:0010831)1.21020808
153Nephropathy (HP:0000112)1.20716399
154Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.19221956
155Supernumerary spleens (HP:0009799)1.18669216
156Congenital malformation of the right heart (HP:0011723)1.18015929
157Double outlet right ventricle (HP:0001719)1.18015929
158Short thorax (HP:0010306)1.16520810
159Vascular calcification (HP:0004934)1.16002824
160Abnormality of ocular smooth pursuit (HP:0000617)1.15061860
161Hemiparesis (HP:0001269)1.13847881
162Median cleft lip (HP:0000161)1.12576019
163True hermaphroditism (HP:0010459)1.12532271
164Broad distal phalanx of finger (HP:0009836)1.12424900
165Polyuria (HP:0000103)1.10967989

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK38.69914649
2PDK48.69914649
3PDK25.63968520
4TESK15.59626670
5DDR25.03331623
6PRKD34.71821412
7INSRR4.08936003
8ICK3.97955510
9MAP4K23.51378594
10PLK23.24492050
11BRD43.19789690
12PTK2B2.33450458
13PNCK2.13213014
14WNK42.12621163
15STK392.01463603
16PIK3CG1.93820838
17MST1R1.66570936
18STK381.57463219
19NEK21.53748921
20DYRK1B1.42096838
21CDK71.34017669
22KSR21.16322925
23PDK11.14855435
24MAP3K91.10186135
25LATS21.03410054
26TYRO30.90391386
27CAMK1D0.89015168
28WNK10.83862618
29DYRK30.80676327
30UHMK10.80069043
31AKT30.78358803
32MAPK150.76898483
33MAP3K110.76721485
34IRAK10.75663796
35LMTK20.69691799
36PASK0.67205664
37PRKAA20.66504139
38MAP2K20.66440935
39MAP2K60.66085731
40CAMK1G0.64583518
41RPS6KA20.64417419
42MAP3K20.64354595
43PDPK10.63666969
44STK30.60123798
45TTK0.59826460
46CHEK20.56275725
47CCNB10.56120168
48TESK20.54799569
49ROCK10.53383685
50CAMK10.53263775
51SIK20.52676645
52RIPK40.52483399
53MAP3K80.52239620
54CDK30.49927521
55MARK10.48779231
56EEF2K0.48689133
57BMPR1B0.47197452
58LATS10.42881529
59IRAK20.42178743
60PINK10.41576878
61CHEK10.41084299
62ARAF0.38837865
63PAK10.38470828
64STK38L0.38087424
65SGK2230.37625909
66SGK4940.37625909
67WEE10.35073573
68TIE10.34695212
69CAMK40.34349501
70MAP3K10.34230362
71RPS6KC10.34116805
72RPS6KL10.34116805
73RPS6KA60.34030051
74PLK40.30494743
75PAK20.30490819
76ATM0.29872888
77PRKCG0.28784048
78NTRK30.27974963
79NEK60.27628265
80SGK10.27248545
81NTRK20.27011793
82ATR0.25770499
83MTOR0.25716798
84MUSK0.24964847
85MET0.24333518
86MAPK140.21908948
87MAPK100.21303865
88MAP3K100.21204353
89CDC70.20467246
90MARK20.20423177
91OXSR10.18659902
92ACVR1B0.18533251
93PRKAA10.18495040
94CAMKK10.18329721
95PAK40.17405720
96MAPKAPK50.17280082
97BRSK20.17188019
98AKT10.16384208
99FRK0.15654846
100RPS6KB10.15497488
101MAPK110.14273715
102CDK120.14231187
103PLK10.14149856
104PRKCZ0.13657396
105PRKG20.10661975
106PRKCQ0.10656722
107FER0.10133791
108BLK0.10064206
109CDK150.09270243
110OBSCN0.08443035
111MAP3K130.08011586
112CSNK1D0.07857466
113MAP2K10.07846856
114TNIK0.07173027
115CDK180.06730700
116GSK3B0.06669445
117CSNK2A10.06588370
118ADRBK20.06530177
119MAPK90.06503918
120CDK60.06117394
121SGK20.06018707
122MARK30.05911524
123CDK11A0.05864641
124PRKG10.05167021
125PKN10.05106642
126RPS6KA10.04947438
127BRSK10.04737858
128CDK20.03914531
129PRKACG0.03863602
130CSNK2A20.03707439
131CDK10.03536003
132CDK140.03525615
133WNK30.03119575
134MAPK80.02411019
135STK110.02349730
136ZAP700.02300427
137STK100.02087237
138CAMK2A0.01746417
139PRKCB0.01658086
140CSF1R0.01032577
141PRKDC0.00586160
142MAP3K40.00561419
143PRKCD0.00495567
144MAP3K50.00020989
145RIPK1-0.0332916
146MAPK1-0.0315499
147PRKACA-0.0292170
148PDGFRB-0.0175986
149PRKACB-0.0165073
150CDK4-0.0148519
151RPS6KA3-0.0148200
152PRKCA-0.0048416
153EGFR-0.0038311
154PIM1-0.0020330
155BRAF-0.0007903

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.94627246
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.64160967
3Fatty acid biosynthesis_Homo sapiens_hsa000614.29416230
4Olfactory transduction_Homo sapiens_hsa047403.87750078
5Vitamin B6 metabolism_Homo sapiens_hsa007503.86798905
6Pyruvate metabolism_Homo sapiens_hsa006203.72170663
7Propanoate metabolism_Homo sapiens_hsa006402.93366947
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.75901075
9Linoleic acid metabolism_Homo sapiens_hsa005912.65810382
10Butanoate metabolism_Homo sapiens_hsa006502.65095552
11Glucagon signaling pathway_Homo sapiens_hsa049222.63672855
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.63180998
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.30024462
14Carbohydrate digestion and absorption_Homo sapiens_hsa049732.27987760
15Basal transcription factors_Homo sapiens_hsa030222.25694007
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.05365681
17Glycerolipid metabolism_Homo sapiens_hsa005612.01379652
18Allograft rejection_Homo sapiens_hsa053302.01093004
19Selenocompound metabolism_Homo sapiens_hsa004501.98385735
20Autoimmune thyroid disease_Homo sapiens_hsa053201.97069992
21Type I diabetes mellitus_Homo sapiens_hsa049401.96474593
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.92707081
23PPAR signaling pathway_Homo sapiens_hsa033201.87753984
24Pentose phosphate pathway_Homo sapiens_hsa000301.86029521
25Graft-versus-host disease_Homo sapiens_hsa053321.84610968
26Oocyte meiosis_Homo sapiens_hsa041141.78317920
27Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.66594805
28Phenylalanine metabolism_Homo sapiens_hsa003601.63630608
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.61068620
30Dorso-ventral axis formation_Homo sapiens_hsa043201.59785520
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.55726633
32Viral myocarditis_Homo sapiens_hsa054161.54544728
33Fructose and mannose metabolism_Homo sapiens_hsa000511.52878871
34Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.51138946
35Mineral absorption_Homo sapiens_hsa049781.48079564
36Carbon metabolism_Homo sapiens_hsa012001.46064004
37Amphetamine addiction_Homo sapiens_hsa050311.44263167
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.41329041
39Fanconi anemia pathway_Homo sapiens_hsa034601.40596651
40Arginine and proline metabolism_Homo sapiens_hsa003301.33193288
41Cardiac muscle contraction_Homo sapiens_hsa042601.31080949
42Fatty acid metabolism_Homo sapiens_hsa012121.30874613
43Fatty acid degradation_Homo sapiens_hsa000711.30831271
44Fat digestion and absorption_Homo sapiens_hsa049751.27684644
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.24432296
46Ether lipid metabolism_Homo sapiens_hsa005651.19431815
47Huntingtons disease_Homo sapiens_hsa050161.15479391
48Renin secretion_Homo sapiens_hsa049241.14640587
49Antigen processing and presentation_Homo sapiens_hsa046121.14139308
50Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13221664
51mRNA surveillance pathway_Homo sapiens_hsa030151.09884610
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04191497
53Phototransduction_Homo sapiens_hsa047441.00618981
54Purine metabolism_Homo sapiens_hsa002300.99049091
55Arginine biosynthesis_Homo sapiens_hsa002200.98960168
56Biosynthesis of amino acids_Homo sapiens_hsa012300.96806217
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92699680
58RNA transport_Homo sapiens_hsa030130.91197118
59Glutathione metabolism_Homo sapiens_hsa004800.88612722
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86850957
61Collecting duct acid secretion_Homo sapiens_hsa049660.83600254
62Morphine addiction_Homo sapiens_hsa050320.83540464
63Influenza A_Homo sapiens_hsa051640.83206984
64Insulin secretion_Homo sapiens_hsa049110.76554048
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75956065
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.75170335
67Bile secretion_Homo sapiens_hsa049760.74203284
68Renin-angiotensin system_Homo sapiens_hsa046140.73883080
69Chemical carcinogenesis_Homo sapiens_hsa052040.72543133
70Thyroid hormone synthesis_Homo sapiens_hsa049180.71809266
71Estrogen signaling pathway_Homo sapiens_hsa049150.71062028
72Nicotine addiction_Homo sapiens_hsa050330.68939067
73Tyrosine metabolism_Homo sapiens_hsa003500.68785373
74Long-term potentiation_Homo sapiens_hsa047200.68628607
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68385042
76Hedgehog signaling pathway_Homo sapiens_hsa043400.68239987
77cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65291603
78Arachidonic acid metabolism_Homo sapiens_hsa005900.64207197
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.62291787
80Primary bile acid biosynthesis_Homo sapiens_hsa001200.61155789
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.60750814
82Legionellosis_Homo sapiens_hsa051340.59437930
83Retinol metabolism_Homo sapiens_hsa008300.58951341
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58188892
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57874427
86Calcium signaling pathway_Homo sapiens_hsa040200.55860074
87Protein digestion and absorption_Homo sapiens_hsa049740.53243774
88Glutamatergic synapse_Homo sapiens_hsa047240.53085287
89Inositol phosphate metabolism_Homo sapiens_hsa005620.52901171
90Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52206778
91ABC transporters_Homo sapiens_hsa020100.49555751
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49072600
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48899631
94Pancreatic secretion_Homo sapiens_hsa049720.48530164
95MAPK signaling pathway_Homo sapiens_hsa040100.48278005
96Salivary secretion_Homo sapiens_hsa049700.47477081
97Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.47443840
98Systemic lupus erythematosus_Homo sapiens_hsa053220.46313243
99Endocytosis_Homo sapiens_hsa041440.45417239
100AMPK signaling pathway_Homo sapiens_hsa041520.45346259
101Tight junction_Homo sapiens_hsa045300.45326478
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43546868
103Acute myeloid leukemia_Homo sapiens_hsa052210.41864142
104Gastric acid secretion_Homo sapiens_hsa049710.41648732
105Synaptic vesicle cycle_Homo sapiens_hsa047210.40584347
106Taste transduction_Homo sapiens_hsa047420.38947067
107Metabolic pathways_Homo sapiens_hsa011000.37408088
108Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.37204437
109Sulfur metabolism_Homo sapiens_hsa009200.36841137
110ECM-receptor interaction_Homo sapiens_hsa045120.34846893
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34816294
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34732914
113Serotonergic synapse_Homo sapiens_hsa047260.33723379
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.33324981
115Cholinergic synapse_Homo sapiens_hsa047250.33305837
116VEGF signaling pathway_Homo sapiens_hsa043700.33178291
117cAMP signaling pathway_Homo sapiens_hsa040240.32523961
118Viral carcinogenesis_Homo sapiens_hsa052030.31037920
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.29326509
120Oxytocin signaling pathway_Homo sapiens_hsa049210.28864131
121Circadian entrainment_Homo sapiens_hsa047130.28596997
122Nitrogen metabolism_Homo sapiens_hsa009100.26557577
123GABAergic synapse_Homo sapiens_hsa047270.25914808
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21474901
125Herpes simplex infection_Homo sapiens_hsa051680.21405855
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20418657
127Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.20223683
128Prolactin signaling pathway_Homo sapiens_hsa049170.18333741
129Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.18228726
130Pyrimidine metabolism_Homo sapiens_hsa002400.17237092
131Alcoholism_Homo sapiens_hsa050340.16747583
132Toxoplasmosis_Homo sapiens_hsa051450.15413656
133Adherens junction_Homo sapiens_hsa045200.15146078
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.14910742
135Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.14888979
136N-Glycan biosynthesis_Homo sapiens_hsa005100.14128648
137Cocaine addiction_Homo sapiens_hsa050300.13507997
138B cell receptor signaling pathway_Homo sapiens_hsa046620.11338366
139HIF-1 signaling pathway_Homo sapiens_hsa040660.07556062
140Salmonella infection_Homo sapiens_hsa051320.06935203
141Wnt signaling pathway_Homo sapiens_hsa043100.06461564
142Insulin resistance_Homo sapiens_hsa049310.03574654
143Type II diabetes mellitus_Homo sapiens_hsa049300.02926212

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