CCDC53

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.71518503
2proteasome assembly (GO:0043248)4.75174912
3SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.74946963
4viral transcription (GO:0019083)4.74458805
5cotranslational protein targeting to membrane (GO:0006613)4.69083661
6ribosomal small subunit biogenesis (GO:0042274)4.68265387
7protein targeting to ER (GO:0045047)4.65401863
8translational termination (GO:0006415)4.60732623
9protein localization to endoplasmic reticulum (GO:0070972)4.47939379
10establishment of protein localization to endoplasmic reticulum (GO:0072599)4.41265993
11signal peptide processing (GO:0006465)4.29956425
12DNA deamination (GO:0045006)4.16551037
13termination of RNA polymerase III transcription (GO:0006386)4.01147001
14transcription elongation from RNA polymerase III promoter (GO:0006385)4.01147001
15antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.99762579
16translational elongation (GO:0006414)3.92180218
17antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.87214904
18RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.78307368
19tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.78307368
20establishment of protein localization to mitochondrial membrane (GO:0090151)3.76499494
21ribosomal large subunit biogenesis (GO:0042273)3.68818866
22viral life cycle (GO:0019058)3.66155838
23regulation of memory T cell differentiation (GO:0043380)3.66139111
24sequestering of actin monomers (GO:0042989)3.65937870
25negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.61809974
26regulation of cellular amino acid metabolic process (GO:0006521)3.61802809
27DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.61654219
28translation (GO:0006412)3.60813531
29signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.54470683
30signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.54470683
31signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.54470683
32intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.54210078
33signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.54210078
34cellular protein complex disassembly (GO:0043624)3.53750082
35response to interferon-beta (GO:0035456)3.49282324
36GTP biosynthetic process (GO:0006183)3.47655112
37translational initiation (GO:0006413)3.47638568
38peptidyl-histidine modification (GO:0018202)3.47049564
39maturation of SSU-rRNA (GO:0030490)3.44253736
40signal transduction involved in DNA damage checkpoint (GO:0072422)3.38397539
41signal transduction involved in DNA integrity checkpoint (GO:0072401)3.38397539
42protein neddylation (GO:0045116)3.37917377
43adenosine metabolic process (GO:0046085)3.37589879
44cellular ketone body metabolic process (GO:0046950)3.37031657
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.36150129
46signal transduction involved in cell cycle checkpoint (GO:0072395)3.33130542
47protein complex biogenesis (GO:0070271)3.33091860
48positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.31987216
49nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.26394174
50mitochondrial respiratory chain complex I assembly (GO:0032981)3.25981898
51NADH dehydrogenase complex assembly (GO:0010257)3.25981898
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.25981898
53antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.25363458
54negative regulation of ligase activity (GO:0051352)3.24387575
55negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.24387575
56epithelial cilium movement (GO:0003351)3.23669553
57regulation of hexokinase activity (GO:1903299)3.22362433
58regulation of glucokinase activity (GO:0033131)3.22362433
59water-soluble vitamin biosynthetic process (GO:0042364)3.21322963
60mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.20874754
61regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.17791570
62regulation of cilium movement (GO:0003352)3.16481724
63proton transport (GO:0015992)3.12769959
64hydrogen ion transmembrane transport (GO:1902600)3.11684974
65guanosine-containing compound biosynthetic process (GO:1901070)3.10222205
66respiratory chain complex IV assembly (GO:0008535)3.10185167
67cellular response to interferon-beta (GO:0035458)3.09514142
68cornea development in camera-type eye (GO:0061303)3.09401709
69hydrogen transport (GO:0006818)3.09197103
70mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.08765120
71energy coupled proton transport, down electrochemical gradient (GO:0015985)3.05435988
72ATP synthesis coupled proton transport (GO:0015986)3.05435988
73daunorubicin metabolic process (GO:0044597)3.04235361
74polyketide metabolic process (GO:0030638)3.04235361
75doxorubicin metabolic process (GO:0044598)3.04235361
76regulation of mitochondrial translation (GO:0070129)3.04016733
77protein localization to cilium (GO:0061512)3.03876613
78ketone body metabolic process (GO:1902224)3.03436302
79iron-sulfur cluster assembly (GO:0016226)3.01896098
80metallo-sulfur cluster assembly (GO:0031163)3.01896098
81ribonucleoprotein complex biogenesis (GO:0022613)3.01764989
82GDP-mannose metabolic process (GO:0019673)3.01005362
83protein targeting to membrane (GO:0006612)2.97780641
847-methylguanosine mRNA capping (GO:0006370)2.97713356
85estrogen biosynthetic process (GO:0006703)2.97580756
86mannosylation (GO:0097502)2.96677935
87cytochrome complex assembly (GO:0017004)2.96065017
88negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.95452273
89mitochondrial respiratory chain complex assembly (GO:0033108)2.94982348
90cullin deneddylation (GO:0010388)2.93604607
91L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.93309281
927-methylguanosine RNA capping (GO:0009452)2.91112812
93RNA capping (GO:0036260)2.91112812
94anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.90666220
95UTP biosynthetic process (GO:0006228)2.89838633
96cellular component biogenesis (GO:0044085)2.89425877
97xenobiotic catabolic process (GO:0042178)2.88495059
98nucleotide transmembrane transport (GO:1901679)2.83422191
99CTP biosynthetic process (GO:0006241)2.83187988
100CTP metabolic process (GO:0046036)2.83187988
101respiratory electron transport chain (GO:0022904)2.83059457
102protein complex disassembly (GO:0043241)2.81862975
103chaperone-mediated protein transport (GO:0072321)2.81430856
104protein deneddylation (GO:0000338)2.81009658
105positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.78172182
106ADP metabolic process (GO:0046031)2.77366141
107axoneme assembly (GO:0035082)2.76285383
108negative regulation of multicellular organism growth (GO:0040015)2.75734253
109electron transport chain (GO:0022900)2.75542622
110protein-cofactor linkage (GO:0018065)2.74548895
111intraciliary transport (GO:0042073)2.74222755
112ATP biosynthetic process (GO:0006754)2.73709778
113neutrophil activation involved in immune response (GO:0002283)2.73268729
114positive regulation of ligase activity (GO:0051351)2.71989634
115DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.71765661
116positive regulation of cell cycle arrest (GO:0071158)2.71204004
117seminiferous tubule development (GO:0072520)2.70112296
118cellular biogenic amine catabolic process (GO:0042402)2.69305500
119amine catabolic process (GO:0009310)2.69305500
120negative regulation of response to food (GO:0032096)2.69252994
121negative regulation of appetite (GO:0032099)2.69252994
122macromolecular complex disassembly (GO:0032984)2.69184032
123tryptophan catabolic process (GO:0006569)2.68422809
124indole-containing compound catabolic process (GO:0042436)2.68422809
125indolalkylamine catabolic process (GO:0046218)2.68422809
126purine nucleoside triphosphate biosynthetic process (GO:0009145)2.67969239
127dopamine transport (GO:0015872)2.67907016
128L-methionine salvage (GO:0071267)2.66669343
129L-methionine biosynthetic process (GO:0071265)2.66669343
130amino acid salvage (GO:0043102)2.66669343
131preassembly of GPI anchor in ER membrane (GO:0016254)2.65581296
132regulation of cellular amine metabolic process (GO:0033238)2.65222002
133cell wall macromolecule catabolic process (GO:0016998)2.65058127
134platelet dense granule organization (GO:0060155)2.63698700
135nonmotile primary cilium assembly (GO:0035058)2.63123499
136inositol phosphate catabolic process (GO:0071545)2.62835343
137behavioral response to nicotine (GO:0035095)2.62288512
138negative regulation of mast cell activation (GO:0033004)2.61917152
139autophagic vacuole fusion (GO:0000046)2.61605030
140purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.60852742
141deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.60148270
142GPI anchor metabolic process (GO:0006505)2.59983335
143C-terminal protein lipidation (GO:0006501)2.59701680
144protein targeting to mitochondrion (GO:0006626)2.59607186
145negative regulation of telomere maintenance (GO:0032205)2.58685138
146rRNA modification (GO:0000154)2.58569062
147pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.57817341
148cell wall macromolecule metabolic process (GO:0044036)2.56516490
149oxidative phosphorylation (GO:0006119)2.56352262
150response to pheromone (GO:0019236)2.55296912
151endosome to pigment granule transport (GO:0043485)2.54418564
152endosome to melanosome transport (GO:0035646)2.54418564
153exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.53867588
154nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.53070340
155positive regulation of TOR signaling (GO:0032008)2.52825520
156C-terminal protein amino acid modification (GO:0018410)2.51804859
157inositol phosphate dephosphorylation (GO:0046855)2.50874147
158phosphorylated carbohydrate dephosphorylation (GO:0046838)2.50874147
159UTP metabolic process (GO:0046051)2.49665575
160indolalkylamine metabolic process (GO:0006586)2.49653238
161amino sugar catabolic process (GO:0046348)2.48719369
162formation of translation preinitiation complex (GO:0001731)2.48584941
163cilium morphogenesis (GO:0060271)2.48561438
164intracellular protein transmembrane import (GO:0044743)2.46868771
165cilium movement (GO:0003341)2.46273982
166regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.45299226
167heart contraction (GO:0060047)2.44244280
168heart process (GO:0003015)2.44244280
169bile acid biosynthetic process (GO:0006699)2.44020617
170branched-chain amino acid catabolic process (GO:0009083)2.41611514
171detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.41492193
172GPI anchor biosynthetic process (GO:0006506)2.38613947

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.22983276
2* GABP_17652178_ChIP-ChIP_JURKAT_Human4.17266608
3* EST1_17652178_ChIP-ChIP_JURKAT_Human3.65767778
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.65696027
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.60463146
6ELF1_17652178_ChIP-ChIP_JURKAT_Human3.45938885
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.44443212
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.36882200
9VDR_22108803_ChIP-Seq_LS180_Human3.16187183
10IRF8_22096565_ChIP-ChIP_GC-B_Human3.15981689
11MYC_18555785_ChIP-Seq_MESCs_Mouse3.14280166
12* ETS1_20019798_ChIP-Seq_JURKAT_Human3.02626052
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.98375077
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.81519406
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.72609771
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.67908024
17SRF_21415370_ChIP-Seq_HL-1_Mouse2.66427771
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.63497940
19VDR_23849224_ChIP-Seq_CD4+_Human2.63315569
20GBX2_23144817_ChIP-Seq_PC3_Human2.60935411
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.56051096
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.52973083
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.48430028
24ZNF274_21170338_ChIP-Seq_K562_Hela2.48321357
25IRF8_21731497_ChIP-ChIP_J774_Mouse2.47642813
26IGF1R_20145208_ChIP-Seq_DFB_Human2.45329776
27ELK1_19687146_ChIP-ChIP_HELA_Human2.41240367
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.38072598
29* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.36836009
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.34352312
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.30404778
32ZFP57_27257070_Chip-Seq_ESCs_Mouse2.27582857
33HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24894857
34DCP1A_22483619_ChIP-Seq_HELA_Human2.21433628
35TAF15_26573619_Chip-Seq_HEK293_Human2.18071236
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.16329801
37SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.08722459
38FOXP3_21729870_ChIP-Seq_TREG_Human2.08156371
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.06071905
40* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02741947
41HOXB4_20404135_ChIP-ChIP_EML_Mouse2.00148345
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.97977119
43FUS_26573619_Chip-Seq_HEK293_Human1.94773215
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91282441
45P300_19829295_ChIP-Seq_ESCs_Human1.77607113
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.77031728
47CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.75544174
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.73295510
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73031878
50EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.71442043
51ELK1_22589737_ChIP-Seq_MCF10A_Human1.70349328
52XRN2_22483619_ChIP-Seq_HELA_Human1.69115998
53BCAT_22108803_ChIP-Seq_LS180_Human1.68964791
54EZH2_22144423_ChIP-Seq_EOC_Human1.68500633
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68194920
56HTT_18923047_ChIP-ChIP_STHdh_Human1.67709905
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.67285025
58CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.66062512
59ER_23166858_ChIP-Seq_MCF-7_Human1.65527165
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60108733
61YY1_21170310_ChIP-Seq_MESCs_Mouse1.60079737
62TP53_22573176_ChIP-Seq_HFKS_Human1.59797026
63SPI1_23547873_ChIP-Seq_NB4_Human1.59654906
64EWS_26573619_Chip-Seq_HEK293_Human1.58226817
65TTF2_22483619_ChIP-Seq_HELA_Human1.58089455
66GABP_19822575_ChIP-Seq_HepG2_Human1.57653085
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.55510573
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55338586
69NOTCH1_21737748_ChIP-Seq_TLL_Human1.54699907
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54691277
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47125076
72SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46987756
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44647933
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44009305
75FOXA1_25329375_ChIP-Seq_VCAP_Human1.43727455
76FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43727455
77STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.41200526
78THAP11_20581084_ChIP-Seq_MESCs_Mouse1.40957318
79SOX2_19829295_ChIP-Seq_ESCs_Human1.40808915
80NANOG_19829295_ChIP-Seq_ESCs_Human1.40808915
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.37796028
82* EZH2_27294783_Chip-Seq_NPCs_Mouse1.37572074
83NFE2_27457419_Chip-Seq_LIVER_Mouse1.37237456
84MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36538799
85CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.36471775
86SMAD4_21799915_ChIP-Seq_A2780_Human1.36398478
87CBP_20019798_ChIP-Seq_JUKART_Human1.35959894
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35959894
89* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34899694
90AR_25329375_ChIP-Seq_VCAP_Human1.34245184
91SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33218633
92PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32880972
93IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.32131301
94FOXA1_21572438_ChIP-Seq_LNCaP_Human1.30888514
95* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30551099
96AR_20517297_ChIP-Seq_VCAP_Human1.30338710
97RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.28976840
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.27582555
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27164193
100PIAS1_25552417_ChIP-Seq_VCAP_Human1.19793558
101FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.19754568
102E2F7_22180533_ChIP-Seq_HELA_Human1.19704584
103IRF8_27001747_Chip-Seq_BMDM_Mouse1.19458785
104PCGF2_27294783_Chip-Seq_ESCs_Mouse1.18753536
105FLI1_27457419_Chip-Seq_LIVER_Mouse1.18519484
106RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18203667
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18070566
108GATA1_22025678_ChIP-Seq_K562_Human1.17630436
109LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17279831
110ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.16722123
111* CRX_20693478_ChIP-Seq_RETINA_Mouse1.16388438
112NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15863233
113MYC_18940864_ChIP-ChIP_HL60_Human1.15682106
114NANOG_18555785_Chip-Seq_ESCs_Mouse1.15577280
115ERG_20517297_ChIP-Seq_VCAP_Human1.15461053
116PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15169103
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.15158363
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15002322
119MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14759495
120MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14577394
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13396567
122TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13313582
123GATA3_21878914_ChIP-Seq_MCF-7_Human1.13051927
124P53_22387025_ChIP-Seq_ESCs_Mouse1.12649343
125CDX2_22108803_ChIP-Seq_LS180_Human1.12306989
126TCF4_22108803_ChIP-Seq_LS180_Human1.10824579
127KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09912192
128ETV2_25802403_ChIP-Seq_MESCs_Mouse1.09271947
129STAT3_18555785_Chip-Seq_ESCs_Mouse1.09045714
130NCOR_22424771_ChIP-Seq_293T_Human1.09032638
131* FOXH1_21741376_ChIP-Seq_EPCs_Human1.07325215
132ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06633063
133MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06553890
134* STAT3_23295773_ChIP-Seq_U87_Human1.06204173
135GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06122853
136TCF4_23295773_ChIP-Seq_U87_Human1.05476686
137FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.04930256
138SMAD3_21741376_ChIP-Seq_EPCs_Human1.04049481
139IRF1_19129219_ChIP-ChIP_H3396_Human1.03986271
140POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.03081005
141GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.01986456
142TAL1_26923725_Chip-Seq_HPCs_Mouse1.01055286
143* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.00662007
144TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00661871
145* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00385273
146PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00019174
147E2F1_18555785_Chip-Seq_ESCs_Mouse0.98721339
148CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98312033
149SMAD4_21741376_ChIP-Seq_EPCs_Human0.97998466
150PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97818854
151BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96914795
152CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.96811585
153EGR1_23403033_ChIP-Seq_LIVER_Mouse0.96128300
154PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95881888
155YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93561376
156NANOG_18555785_ChIP-Seq_MESCs_Mouse0.93328853
157HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90439203
158MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.90008850
159SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.89536883
160TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89167501
161TFEB_21752829_ChIP-Seq_HELA_Human0.87247111
162FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87131407
163NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.86303353
164LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.86205607
165SOX17_20123909_ChIP-Seq_XEN_Mouse0.84997355
166MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.84076448
167CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83427902
168TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81936754
169HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80656968
170RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.80543710
171PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79129422
172SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78715151
173MYCN_18555785_ChIP-Seq_MESCs_Mouse0.77597668
174CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77322008
175CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.76725550

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.34761087
2MP0002837_dystrophic_cardiac_calcinosis3.73772611
3MP0001835_abnormal_antigen_presentation3.41889534
4MP0009379_abnormal_foot_pigmentation3.33328772
5MP0003724_increased_susceptibility_to3.24390181
6MP0009785_altered_susceptibility_to3.09107109
7MP0002148_abnormal_hypersensitivity_rea2.98092492
8MP0005671_abnormal_response_to2.86028444
9MP0003186_abnormal_redox_activity2.63739591
10MP0006072_abnormal_retinal_apoptosis2.52451599
11MP0003787_abnormal_imprinting2.28498938
12MP0009697_abnormal_copulation2.26724333
13MP0005000_abnormal_immune_tolerance2.25987994
14MP0003436_decreased_susceptibility_to2.23599370
15MP0009333_abnormal_splenocyte_physiolog2.18813137
16MP0005025_abnormal_response_to2.14559239
17MP0001986_abnormal_taste_sensitivity2.09251245
18MP0002736_abnormal_nociception_after2.08594689
19MP0005551_abnormal_eye_electrophysiolog2.05079304
20MP0002419_abnormal_innate_immunity2.02155751
21MP0003693_abnormal_embryo_hatching2.01838667
22MP0001968_abnormal_touch/_nociception2.01568529
23MP0005253_abnormal_eye_physiology1.97724645
24MP0000685_abnormal_immune_system1.97032843
25MP0003252_abnormal_bile_duct1.94713867
26MP0002132_abnormal_respiratory_system1.94377861
27MP0003136_yellow_coat_color1.93744265
28MP0002723_abnormal_immune_serum1.90399097
29MP0005646_abnormal_pituitary_gland1.89781220
30MP0003763_abnormal_thymus_physiology1.88721304
31MP0008877_abnormal_DNA_methylation1.86077488
32MP0003195_calcinosis1.85470255
33MP0000372_irregular_coat_pigmentation1.85320574
34MP0002452_abnormal_antigen_presenting1.85147287
35MP0001800_abnormal_humoral_immune1.81649157
36MP0004142_abnormal_muscle_tone1.77729552
37MP0006082_CNS_inflammation1.77358860
38MP0002420_abnormal_adaptive_immunity1.77144856
39MP0005645_abnormal_hypothalamus_physiol1.77100741
40MP0001819_abnormal_immune_cell1.76897802
41MP0008058_abnormal_DNA_repair1.76323633
42MP0003941_abnormal_skin_development1.75351042
43MP0001542_abnormal_bone_strength1.71571598
44MP0001790_abnormal_immune_system1.71149365
45MP0005387_immune_system_phenotype1.71149365
46MP0009046_muscle_twitch1.68812176
47MP0001905_abnormal_dopamine_level1.65462377
48MP0002102_abnormal_ear_morphology1.62091641
49MP0005410_abnormal_fertilization1.59987494
50MP0002163_abnormal_gland_morphology1.59039455
51MP0002638_abnormal_pupillary_reflex1.56287223
52MP0003880_abnormal_central_pattern1.54867919
53MP0008007_abnormal_cellular_replicative1.51999525
54MP0001853_heart_inflammation1.51256042
55MP0002405_respiratory_system_inflammati1.51056893
56MP0001764_abnormal_homeostasis1.48712251
57MP0004147_increased_porphyrin_level1.48323811
58MP0001984_abnormal_olfaction1.47080928
59MP0002396_abnormal_hematopoietic_system1.46875992
60MP0008875_abnormal_xenobiotic_pharmacok1.46277498
61MP0008789_abnormal_olfactory_epithelium1.43844975
62MP0003786_premature_aging1.41164208
63MP0003806_abnormal_nucleotide_metabolis1.40724030
64MP0009745_abnormal_behavioral_response1.40146274
65MP0001845_abnormal_inflammatory_respons1.38771008
66MP0004215_abnormal_myocardial_fiber1.37880502
67MP0001533_abnormal_skeleton_physiology1.35980832
68MP0008872_abnormal_physiological_respon1.35717771
69MP0000716_abnormal_immune_system1.34648199
70MP0006276_abnormal_autonomic_nervous1.33382250
71MP0008469_abnormal_protein_level1.33376377
72MP0006036_abnormal_mitochondrial_physio1.32982596
73MP0002876_abnormal_thyroid_physiology1.32949193
74MP0002272_abnormal_nervous_system1.32612985
75MP0002398_abnormal_bone_marrow1.29410699
76MP0002933_joint_inflammation1.27718799
77MP0006292_abnormal_olfactory_placode1.26648415
78MP0003718_maternal_effect1.26149658
79MP0004782_abnormal_surfactant_physiolog1.25692180
80MP0002693_abnormal_pancreas_physiology1.25577409
81MP0005075_abnormal_melanosome_morpholog1.24977774
82MP0004957_abnormal_blastocyst_morpholog1.24900700
83MP0005379_endocrine/exocrine_gland_phen1.24015091
84MP0002006_tumorigenesis1.23726374
85MP0000681_abnormal_thyroid_gland1.23259177
86MP0005058_abnormal_lysosome_morphology1.21894084
87MP0005084_abnormal_gallbladder_morpholo1.20628776
88MP0002938_white_spotting1.20529181
89MP0005085_abnormal_gallbladder_physiolo1.20021123
90MP0002277_abnormal_respiratory_mucosa1.18851766
91MP0000689_abnormal_spleen_morphology1.18491982
92MP0002909_abnormal_adrenal_gland1.16892177
93MP0002429_abnormal_blood_cell1.15954809
94MP0002722_abnormal_immune_system1.15354043
95MP0010155_abnormal_intestine_physiology1.12824937
96MP0008775_abnormal_heart_ventricle1.10174662
97MP0004381_abnormal_hair_follicle1.09948337
98MP0000490_abnormal_crypts_of1.07856873
99MP0005332_abnormal_amino_acid1.06743747
100MP0005408_hypopigmentation1.06472876
101MP0002095_abnormal_skin_pigmentation1.05543780
102MP0002090_abnormal_vision1.05063570
103MP0008932_abnormal_embryonic_tissue1.04495643
104MP0001970_abnormal_pain_threshold1.02125758
105MP0004043_abnormal_pH_regulation1.01273523
106MP0000230_abnormal_systemic_arterial1.00604105
107MP0005464_abnormal_platelet_physiology0.99660989
108MP0001756_abnormal_urination0.99378613
109MP0002234_abnormal_pharynx_morphology0.99309926
110MP0001529_abnormal_vocalization0.99215699
111MP0005174_abnormal_tail_pigmentation0.99078879
112MP0002160_abnormal_reproductive_system0.98409083
113MP0005310_abnormal_salivary_gland0.98016562
114MP0005390_skeleton_phenotype0.98012996
115MP0003137_abnormal_impulse_conducting0.97047386
116MP0001188_hyperpigmentation0.97036883
117MP0002166_altered_tumor_susceptibility0.96556654
118MP0000858_altered_metastatic_potential0.96367606
119MP0002928_abnormal_bile_duct0.96116048
120MP0005083_abnormal_biliary_tract0.95971050
121MP0003646_muscle_fatigue0.95894212
122MP0010094_abnormal_chromosome_stability0.94692358
123MP0005367_renal/urinary_system_phenotyp0.94646108
124MP0000516_abnormal_urinary_system0.94646108
125MP0005365_abnormal_bile_salt0.94315855
126MP0000678_abnormal_parathyroid_gland0.93070460
127MP0001501_abnormal_sleep_pattern0.92965410
128MP0000427_abnormal_hair_cycle0.92498233
129MP0000631_abnormal_neuroendocrine_gland0.92315521
130MP0009780_abnormal_chondrocyte_physiolo0.92133211
131MP0003866_abnormal_defecation0.92090049
132MP0000015_abnormal_ear_pigmentation0.91947296
133MP0005171_absent_coat_pigmentation0.90728941
134MP0010386_abnormal_urinary_bladder0.90187068
135MP0005499_abnormal_olfactory_system0.89301950
136MP0005394_taste/olfaction_phenotype0.89301950
137MP0002653_abnormal_ependyma_morphology0.86279439
138MP0004808_abnormal_hematopoietic_stem0.85862975
139MP0002064_seizures0.84491544
140MP0003121_genomic_imprinting0.83353334
141MP0000343_altered_response_to0.83142934
142MP0003077_abnormal_cell_cycle0.82812369
143MP0009764_decreased_sensitivity_to0.82249510
144MP0002733_abnormal_thermal_nociception0.82037050
145MP0002229_neurodegeneration0.80875277
146MP0002067_abnormal_sensory_capabilities0.80223880
147MP0000703_abnormal_thymus_morphology0.79901224
148MP0008057_abnormal_DNA_replication0.79252823
149MP0001485_abnormal_pinna_reflex0.78119340
150MP0010329_abnormal_lipoprotein_level0.77974963
151MP0005636_abnormal_mineral_homeostasis0.76876245
152MP0005503_abnormal_tendon_morphology0.76823341
153MP0006035_abnormal_mitochondrial_morpho0.76194604
154MP0001944_abnormal_pancreas_morphology0.75866070
155MP0002572_abnormal_emotion/affect_behav0.75442242
156MP0002139_abnormal_hepatobiliary_system0.75064215
157MP0006054_spinal_hemorrhage0.74618774
158MP0002998_abnormal_bone_remodeling0.73989838
159MP0001486_abnormal_startle_reflex0.73957713
160MP0003828_pulmonary_edema0.72826158
161MP0005195_abnormal_posterior_eye0.72589763
162MP0002557_abnormal_social/conspecific_i0.71955317
163MP0008004_abnormal_stomach_pH0.71430124
164MP0005389_reproductive_system_phenotype0.70933325
165MP0002138_abnormal_hepatobiliary_system0.70074906
166MP0005397_hematopoietic_system_phenotyp0.70065687
167MP0001545_abnormal_hematopoietic_system0.70065687
168MP0000613_abnormal_salivary_gland0.69694455
169MP0000566_synostosis0.69554662

Predicted human phenotypes

RankGene SetZ-score
13-Methylglutaconic aciduria (HP:0003535)4.14570052
2Acute necrotizing encephalopathy (HP:0006965)3.83071717
3Mitochondrial inheritance (HP:0001427)3.72944694
4Reticulocytopenia (HP:0001896)3.72786725
5Abnormality of cells of the erythroid lineage (HP:0012130)3.64632892
6Vacuolated lymphocytes (HP:0001922)3.52511393
7Hepatic necrosis (HP:0002605)3.51872173
8Hepatocellular necrosis (HP:0001404)3.51022637
9Abnormal number of erythroid precursors (HP:0012131)3.49542979
10Molar tooth sign on MRI (HP:0002419)3.48868983
11Abnormality of midbrain morphology (HP:0002418)3.48868983
12Increased hepatocellular lipid droplets (HP:0006565)3.48489870
13Abnormal mitochondria in muscle tissue (HP:0008316)3.44026533
14Type I transferrin isoform profile (HP:0003642)3.41092967
15Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.33291642
16Increased CSF lactate (HP:0002490)3.30941869
17Nephronophthisis (HP:0000090)3.20158439
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.19255194
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.19255194
20Exertional dyspnea (HP:0002875)3.18511624
21Lipid accumulation in hepatocytes (HP:0006561)3.18009604
22Renal Fanconi syndrome (HP:0001994)3.17543670
23Acute encephalopathy (HP:0006846)3.06045562
24Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.00715502
25Progressive macrocephaly (HP:0004481)2.97587765
26Recurrent abscess formation (HP:0002722)2.97053591
27Macrocytic anemia (HP:0001972)2.86482895
28Reduced antithrombin III activity (HP:0001976)2.76871708
29Abnormal rod and cone electroretinograms (HP:0008323)2.72460656
30Poor head control (HP:0002421)2.71839650
31Abnormality of the renal cortex (HP:0011035)2.71629987
32Increased serum lactate (HP:0002151)2.69417430
33Aplasia/Hypoplasia of the fovea (HP:0008060)2.68495491
34Hypoplasia of the fovea (HP:0007750)2.68495491
35Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.67486790
36Abnormal protein N-linked glycosylation (HP:0012347)2.67486790
37Abnormal protein glycosylation (HP:0012346)2.67486790
38Abnormal glycosylation (HP:0012345)2.67486790
39Pallor (HP:0000980)2.63679460
40Congenital primary aphakia (HP:0007707)2.59819261
41Thrombocytosis (HP:0001894)2.59650492
42Recurrent bacterial skin infections (HP:0005406)2.57751631
43Gait imbalance (HP:0002141)2.56798566
44Prolonged neonatal jaundice (HP:0006579)2.55661837
45Abnormality of the renal medulla (HP:0100957)2.55294727
46Congenital stationary night blindness (HP:0007642)2.54809335
47Elevated erythrocyte sedimentation rate (HP:0003565)2.53783413
48Increased intramyocellular lipid droplets (HP:0012240)2.51323803
49Abnormality of the fovea (HP:0000493)2.51062357
50True hermaphroditism (HP:0010459)2.47058553
51Pancreatic fibrosis (HP:0100732)2.45581098
52Aplasia/Hypoplasia of the sacrum (HP:0008517)2.44675437
53Abnormality of renal resorption (HP:0011038)2.43075714
54Pancreatic cysts (HP:0001737)2.39745539
55Attenuation of retinal blood vessels (HP:0007843)2.38545507
56Abolished electroretinogram (ERG) (HP:0000550)2.38105772
57Exercise intolerance (HP:0003546)2.37208608
58Abnormality of macrophages (HP:0004311)2.35792186
59Nephrogenic diabetes insipidus (HP:0009806)2.35492293
60Congenital, generalized hypertrichosis (HP:0004540)2.33425278
61Ketoacidosis (HP:0001993)2.32324714
62Microvesicular hepatic steatosis (HP:0001414)2.31772540
63Petechiae (HP:0000967)2.31666887
64Parakeratosis (HP:0001036)2.31333821
65Lactic acidosis (HP:0003128)2.30225395
66Methylmalonic acidemia (HP:0002912)2.28575440
67Generalized aminoaciduria (HP:0002909)2.25726911
68Decreased central vision (HP:0007663)2.25349647
69Aplastic anemia (HP:0001915)2.22450514
70Hypoglycemic coma (HP:0001325)2.21958312
71Absent rod-and cone-mediated responses on ERG (HP:0007688)2.21461836
72Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.21051139
73Chronic otitis media (HP:0000389)2.18801585
74Myositis (HP:0100614)2.18434531
75Respiratory failure (HP:0002878)2.17285907
76Increased muscle lipid content (HP:0009058)2.16925136
77Lethargy (HP:0001254)2.13968724
78IgM deficiency (HP:0002850)2.13468687
79Decreased electroretinogram (ERG) amplitude (HP:0000654)2.12911356
80CNS demyelination (HP:0007305)2.12279603
81Vertebral compression fractures (HP:0002953)2.06801589
82Sclerocornea (HP:0000647)2.04433963
83Abnormal drinking behavior (HP:0030082)2.04202510
84Polydipsia (HP:0001959)2.04202510
85Beaking of vertebral bodies (HP:0004568)2.03943441
86Type 2 muscle fiber atrophy (HP:0003554)2.03148465
87Abnormal hemoglobin (HP:0011902)2.02382942
88Increased corneal curvature (HP:0100692)2.01462729
89Keratoconus (HP:0000563)2.01462729
90Cerebral edema (HP:0002181)2.01452416
91Respiratory difficulties (HP:0002880)1.99879913
92Hypothermia (HP:0002045)1.99205513
93Rough bone trabeculation (HP:0100670)1.99005058
94Eczematoid dermatitis (HP:0000976)1.96847483
95Abnormality of urine glucose concentration (HP:0011016)1.96129983
96Glycosuria (HP:0003076)1.96129983
97Leukodystrophy (HP:0002415)1.95131651
98Progressive cerebellar ataxia (HP:0002073)1.94937236
99Abnormal ciliary motility (HP:0012262)1.94819635
100Sparse eyelashes (HP:0000653)1.94492694
101Methylmalonic aciduria (HP:0012120)1.94458272
102IgG deficiency (HP:0004315)1.93663616
103Abnormal respiratory motile cilium physiology (HP:0012261)1.92910933
104Male pseudohermaphroditism (HP:0000037)1.91729823
105Severe visual impairment (HP:0001141)1.90023344
106Dicarboxylic aciduria (HP:0003215)1.89629258
107Abnormality of dicarboxylic acid metabolism (HP:0010995)1.89629258
108Optic disc pallor (HP:0000543)1.89423054
109Abnormality of the prostate (HP:0008775)1.89218246
110Muscle fiber atrophy (HP:0100295)1.89143723
111Ketosis (HP:0001946)1.88861634
112Renal cortical cysts (HP:0000803)1.88701201
113Large for gestational age (HP:0001520)1.88203514
114X-linked dominant inheritance (HP:0001423)1.86780523
115Recurrent pneumonia (HP:0006532)1.85679582
116Genital tract atresia (HP:0001827)1.85208088
117Optic neuritis (HP:0100653)1.84966915
118Retrobulbar optic neuritis (HP:0100654)1.84966915
119Abnormal respiratory motile cilium morphology (HP:0005938)1.84805581
120Abnormal respiratory epithelium morphology (HP:0012253)1.84805581
121Birth length less than 3rd percentile (HP:0003561)1.84786609
122Thyroiditis (HP:0100646)1.82608999
123Prostate neoplasm (HP:0100787)1.81276389
124Granulocytopenia (HP:0001913)1.80913528
125Purpura (HP:0000979)1.80412351
126Pendular nystagmus (HP:0012043)1.79782299
127Cystic liver disease (HP:0006706)1.79602785
128Abnormality of dental color (HP:0011073)1.79510183
129Pancytopenia (HP:0001876)1.79365358
130Dry hair (HP:0011359)1.79039983
131Hypoproteinemia (HP:0003075)1.78079241
132Abnormality of macular pigmentation (HP:0008002)1.77405353
133Adrenal hypoplasia (HP:0000835)1.77291376
134Vaginal atresia (HP:0000148)1.76896270
13511 pairs of ribs (HP:0000878)1.75593419
136Increased IgM level (HP:0003496)1.75373104
137Retinitis pigmentosa (HP:0000510)1.74122598
138Abnormal trabecular bone morphology (HP:0100671)1.73419396
139Optic nerve hypoplasia (HP:0000609)1.72324362
140Hemiparesis (HP:0001269)1.71650352
141Patchy hypopigmentation of hair (HP:0011365)1.69456438
142Abnormal spermatogenesis (HP:0008669)1.69180806
143Bile duct proliferation (HP:0001408)1.68892826
144Abnormal biliary tract physiology (HP:0012439)1.68892826
145Dialeptic seizures (HP:0011146)1.68594806
146Hyperglycinemia (HP:0002154)1.68337596
147Neutropenia (HP:0001875)1.68124014
148Nausea (HP:0002018)1.67491067
149Eosinophilia (HP:0001880)1.66168284
150Obstructive lung disease (HP:0006536)1.64660110
151Chronic obstructive pulmonary disease (HP:0006510)1.64660110
152Chronic sinusitis (HP:0011109)1.63908142
153Medial flaring of the eyebrow (HP:0010747)1.63873837
154Increased neuronal autofluorescent lipopigment (HP:0002074)1.63281791
155Congenital ichthyosiform erythroderma (HP:0007431)1.63201109
156Proximal tubulopathy (HP:0000114)1.62648235
157Aplasia/hypoplasia of the uterus (HP:0008684)1.61853380
158Hepatosplenomegaly (HP:0001433)1.61449574
159Renal tubular dysfunction (HP:0000124)1.61443415

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.48042046
2NME24.01165823
3STK163.37187055
4PIM22.92235800
5CDK192.85620016
6VRK22.39446212
7MAP4K22.39214627
8IRAK42.22966539
9MST42.22706061
10TXK2.20559424
11BUB12.19996401
12TRIM282.17910325
13IRAK32.10578336
14PBK2.09080849
15EIF2AK12.03207077
16VRK12.00226811
17GRK11.95946981
18TAOK31.95025638
19TEC1.84366642
20EIF2AK31.79150033
21ZAK1.77814701
22BLK1.75594250
23WEE11.74923241
24PLK41.72764880
25OXSR11.71222912
26MAP3K141.70944433
27ARAF1.68362954
28SRPK11.68315209
29MAP3K41.61921281
30MAPK131.61150174
31SIK31.58239749
32WNK31.56180302
33NME11.54685841
34IKBKB1.50747208
35TLK11.49500064
36ERBB31.48406299
37NEK91.47752168
38STK391.46797348
39MUSK1.45800790
40MAP2K71.39789469
41TBK11.39413602
42BMPR21.38956692
43CSNK1G31.34409727
44EIF2AK21.34161037
45WNK41.33120352
46MAP4K11.30882744
47PHKG21.30774818
48PHKG11.30774818
49IKBKE1.29417392
50CSNK1G21.18713395
51KIT1.17696585
52ACVR1B1.17343776
53MAPKAPK31.14719443
54TYK21.14102842
55NLK1.13166770
56JAK31.12564179
57BMPR1B1.11533743
58PTK2B1.10395494
59CSNK1G11.09299743
60MAP3K121.07315281
61ZAP701.06063063
62PLK21.05803934
63PASK1.05270493
64ADRBK21.05247341
65BTK1.03286537
66BRSK21.02296847
67FLT31.01885205
68EPHA20.99882606
69TESK10.99480254
70PAK30.98917693
71TSSK60.98027520
72CASK0.96573794
73MKNK20.96457896
74PIM10.95799184
75IRAK10.95722398
76BRAF0.95707988
77KDR0.95543366
78BCKDK0.94539015
79MYLK0.90654372
80LYN0.89626703
81CSNK1A1L0.86885262
82PRKCE0.86170453
83ADRBK10.86058979
84INSRR0.83613912
85CAMKK20.81890969
86NUAK10.80993947
87YES10.80825061
88MKNK10.79329479
89SYK0.79318760
90ABL20.78983723
91GRK70.78833859
92RPS6KA40.78570969
93TNIK0.76231068
94TESK20.76010357
95TIE10.75456921
96DAPK30.72403162
97MAPK150.71888823
98GRK50.71595001
99ILK0.69332024
100AKT30.69151623
101CCNB10.67516672
102PIK3CG0.66055815
103FER0.65127194
104FGFR20.64782456
105LCK0.63965545
106EPHA30.63161537
107CLK10.62772568
108LMTK20.62634258
109OBSCN0.62510100
110DAPK10.61162981
111PRKCG0.60575931
112IRAK20.60432951
113RPS6KA50.60272257
114CSNK2A10.59650173
115MARK30.59397055
116DYRK20.58162357
117RIPK40.56015218
118CHUK0.55703612
119CAMK2A0.55671357
120CDK80.54451728
121ROCK10.53076826
122BCR0.52402915
123CAMK2D0.51689161
124PINK10.50872129
125PRKCD0.50664012
126NEK60.50216680
127EPHA40.49892759
128PRKCQ0.49727713
129PRKACA0.49152688
130MAP3K110.49030303
131TGFBR10.48507042
132LIMK10.47895975
133PRKG20.46339503
134DYRK30.46284118
135AURKA0.44770843
136PRKG10.44728552
137STK30.44360257
138CSF1R0.44015350
139CSNK2A20.43460094
140MAP3K30.41721271
141AURKB0.40660616
142TRPM70.40269730
143CDK70.40250329
144DAPK20.40039467
145PLK30.39211123
146PLK10.39210187
147TNK20.39037635
148MAP3K50.38142089
149STK38L0.36644060
150PRKCA0.36614735
151ITK0.36596572
152PKN10.35724690
153CSNK1A10.33334649
154MAPKAPK50.32186451
155ABL10.31478733
156IGF1R0.28868848
157MINK10.26224810

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.54518595
2Proteasome_Homo sapiens_hsa030504.46033216
3Protein export_Homo sapiens_hsa030603.99351439
4RNA polymerase_Homo sapiens_hsa030203.26737535
5Oxidative phosphorylation_Homo sapiens_hsa001902.79009827
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.68263831
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.59854507
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.54888132
9Parkinsons disease_Homo sapiens_hsa050122.32397229
10Cardiac muscle contraction_Homo sapiens_hsa042602.23981671
11Pyrimidine metabolism_Homo sapiens_hsa002402.14990931
12Butanoate metabolism_Homo sapiens_hsa006501.99802011
13DNA replication_Homo sapiens_hsa030301.98479650
14Graft-versus-host disease_Homo sapiens_hsa053321.89968338
15Homologous recombination_Homo sapiens_hsa034401.83521890
16Huntingtons disease_Homo sapiens_hsa050161.83282232
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.68399742
18Folate biosynthesis_Homo sapiens_hsa007901.68358307
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68038913
20Allograft rejection_Homo sapiens_hsa053301.66999583
21Propanoate metabolism_Homo sapiens_hsa006401.65078331
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.64108415
23Mismatch repair_Homo sapiens_hsa034301.63399516
24Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.61984613
25Phototransduction_Homo sapiens_hsa047441.61518866
26Nitrogen metabolism_Homo sapiens_hsa009101.57354379
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.57194414
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.56256051
29Alzheimers disease_Homo sapiens_hsa050101.55518286
30Nucleotide excision repair_Homo sapiens_hsa034201.50325962
31Spliceosome_Homo sapiens_hsa030401.38520431
32Basal transcription factors_Homo sapiens_hsa030221.35016049
33Tryptophan metabolism_Homo sapiens_hsa003801.32300545
34Legionellosis_Homo sapiens_hsa051341.30984156
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30032710
36Base excision repair_Homo sapiens_hsa034101.23628695
37Non-homologous end-joining_Homo sapiens_hsa034501.23519507
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.23324392
39Purine metabolism_Homo sapiens_hsa002301.19810038
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.18663416
41Sulfur metabolism_Homo sapiens_hsa009201.18590026
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17553773
43Primary immunodeficiency_Homo sapiens_hsa053401.14857232
44Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.13042366
45Rheumatoid arthritis_Homo sapiens_hsa053231.12147905
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09166712
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07067126
48Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04754912
49Ether lipid metabolism_Homo sapiens_hsa005651.04302074
50Antigen processing and presentation_Homo sapiens_hsa046121.00356594
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97622130
52Type I diabetes mellitus_Homo sapiens_hsa049400.96976305
53Autoimmune thyroid disease_Homo sapiens_hsa053200.96799363
54Arachidonic acid metabolism_Homo sapiens_hsa005900.96168746
55RNA degradation_Homo sapiens_hsa030180.96161829
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.95622876
57Sulfur relay system_Homo sapiens_hsa041220.93932272
58One carbon pool by folate_Homo sapiens_hsa006700.93693932
59Regulation of autophagy_Homo sapiens_hsa041400.92478099
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.91821977
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90668001
62Herpes simplex infection_Homo sapiens_hsa051680.90414212
63Measles_Homo sapiens_hsa051620.90172944
64Olfactory transduction_Homo sapiens_hsa047400.89179867
65Glutathione metabolism_Homo sapiens_hsa004800.89089589
66Malaria_Homo sapiens_hsa051440.88046868
67NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87455472
68Other glycan degradation_Homo sapiens_hsa005110.85798315
69Hematopoietic cell lineage_Homo sapiens_hsa046400.85445191
70Leishmaniasis_Homo sapiens_hsa051400.84398164
71Pentose and glucuronate interconversions_Homo sapiens_hsa000400.84315027
72RNA transport_Homo sapiens_hsa030130.83188219
73Fanconi anemia pathway_Homo sapiens_hsa034600.80980540
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80615963
75Epstein-Barr virus infection_Homo sapiens_hsa051690.78622527
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.76053783
77Asthma_Homo sapiens_hsa053100.75606456
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.72554933
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.71741888
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71499833
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.70551757
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70129927
83Pertussis_Homo sapiens_hsa051330.68068048
84beta-Alanine metabolism_Homo sapiens_hsa004100.66648321
85Fatty acid elongation_Homo sapiens_hsa000620.66487748
86Metabolic pathways_Homo sapiens_hsa011000.66056655
87Pentose phosphate pathway_Homo sapiens_hsa000300.65474482
88Chemical carcinogenesis_Homo sapiens_hsa052040.65379670
89Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64892463
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63099120
91Toll-like receptor signaling pathway_Homo sapiens_hsa046200.61324423
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.61231460
93Fatty acid degradation_Homo sapiens_hsa000710.60852869
94Steroid biosynthesis_Homo sapiens_hsa001000.59965218
95Mineral absorption_Homo sapiens_hsa049780.59467786
96Lysosome_Homo sapiens_hsa041420.59348134
97Serotonergic synapse_Homo sapiens_hsa047260.58165206
98Histidine metabolism_Homo sapiens_hsa003400.57894502
99Sphingolipid metabolism_Homo sapiens_hsa006000.56547729
100Fatty acid metabolism_Homo sapiens_hsa012120.55349102
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53135297
102Phagosome_Homo sapiens_hsa041450.53067781
103Galactose metabolism_Homo sapiens_hsa000520.51984399
104Insulin secretion_Homo sapiens_hsa049110.50565127
105GABAergic synapse_Homo sapiens_hsa047270.49372970
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.49085100
107Circadian rhythm_Homo sapiens_hsa047100.48893764
108Taste transduction_Homo sapiens_hsa047420.48580068
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.48349733
110Influenza A_Homo sapiens_hsa051640.48106252
111Peroxisome_Homo sapiens_hsa041460.46842773
112Linoleic acid metabolism_Homo sapiens_hsa005910.46269499
113p53 signaling pathway_Homo sapiens_hsa041150.45822556
114Pyruvate metabolism_Homo sapiens_hsa006200.45399280
115Vibrio cholerae infection_Homo sapiens_hsa051100.44550278
116Morphine addiction_Homo sapiens_hsa050320.44099859
117Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43187328
118Salivary secretion_Homo sapiens_hsa049700.42830945
119Steroid hormone biosynthesis_Homo sapiens_hsa001400.42631607
120Nicotine addiction_Homo sapiens_hsa050330.42356448
121Vitamin digestion and absorption_Homo sapiens_hsa049770.40413690
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40194943
123Vitamin B6 metabolism_Homo sapiens_hsa007500.38558997
124Retinol metabolism_Homo sapiens_hsa008300.38042734
125African trypanosomiasis_Homo sapiens_hsa051430.37779888
126Circadian entrainment_Homo sapiens_hsa047130.37351366
127Collecting duct acid secretion_Homo sapiens_hsa049660.37252331
128Caffeine metabolism_Homo sapiens_hsa002320.36820492
129Fructose and mannose metabolism_Homo sapiens_hsa000510.36817379
130N-Glycan biosynthesis_Homo sapiens_hsa005100.36561945
131Cell cycle_Homo sapiens_hsa041100.35071636
132Shigellosis_Homo sapiens_hsa051310.34634679
133Salmonella infection_Homo sapiens_hsa051320.33558573
134Synaptic vesicle cycle_Homo sapiens_hsa047210.33030057
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32951254
136Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.32840612
137Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31122737

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