CCDC47

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.33541376
2COPI coating of Golgi vesicle (GO:0048205)6.33541376
3nuclear pore complex assembly (GO:0051292)5.46667997
4nuclear pore organization (GO:0006999)4.72081431
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.62188713
6protein retention in ER lumen (GO:0006621)4.31788216
7desmosome organization (GO:0002934)4.16996245
8pore complex assembly (GO:0046931)4.11488191
9regulation of translational fidelity (GO:0006450)4.06861687
10COPII vesicle coating (GO:0048208)4.04877910
11DNA unwinding involved in DNA replication (GO:0006268)3.98870501
12retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.96157288
13proline biosynthetic process (GO:0006561)3.86830674
14ribosome assembly (GO:0042255)3.85015019
15mitotic chromosome condensation (GO:0007076)3.64255567
16vesicle coating (GO:0006901)3.49418050
17fatty acid elongation (GO:0030497)3.46257449
18protein complex localization (GO:0031503)3.38617169
19cellular protein complex localization (GO:0034629)3.35993413
20nucleobase-containing small molecule interconversion (GO:0015949)3.31853947
21bundle of His cell to Purkinje myocyte communication (GO:0086069)3.22953697
22regulation of mitotic spindle organization (GO:0060236)3.15320406
23mitotic sister chromatid cohesion (GO:0007064)3.14119104
24erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.13317923
25L-phenylalanine catabolic process (GO:0006559)3.13317923
26regulation of RNA export from nucleus (GO:0046831)3.10655757
27protein maturation by protein folding (GO:0022417)3.08101759
28cell adhesion mediated by integrin (GO:0033627)3.03602559
29formation of translation preinitiation complex (GO:0001731)3.01395590
30cellular ketone body metabolic process (GO:0046950)3.00182391
31regulation of translational termination (GO:0006449)2.99905228
32activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.97018124
33regulation of nucleobase-containing compound transport (GO:0032239)2.94355581
34positive regulation of nuclease activity (GO:0032075)2.92675968
35hemidesmosome assembly (GO:0031581)2.88478523
36endoplasmic reticulum unfolded protein response (GO:0030968)2.86158363
37protein localization to endosome (GO:0036010)2.85464432
38spliceosomal tri-snRNP complex assembly (GO:0000244)2.81607879
39protein export from nucleus (GO:0006611)2.80889751
40mitotic sister chromatid segregation (GO:0000070)2.79747377
41skin morphogenesis (GO:0043589)2.78782412
42establishment of integrated proviral latency (GO:0075713)2.78654260
43glucose 6-phosphate metabolic process (GO:0051156)2.76986215
44neuron cell-cell adhesion (GO:0007158)2.76072213
45regulation of cell communication by electrical coupling (GO:0010649)2.75624317
46L-phenylalanine metabolic process (GO:0006558)2.75598442
47erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.75598442
48regulation of short-term neuronal synaptic plasticity (GO:0048172)2.74936436
49* ER-nucleus signaling pathway (GO:0006984)2.74868949
50ketone body metabolic process (GO:1902224)2.71716337
51presynaptic membrane assembly (GO:0097105)2.71517556
52branching involved in mammary gland duct morphogenesis (GO:0060444)2.70923112
53synaptic vesicle exocytosis (GO:0016079)2.70890904
54cytoskeletal anchoring at plasma membrane (GO:0007016)2.70803713
55negative regulation of neurotransmitter transport (GO:0051589)2.69894655
56negative regulation of neurotransmitter secretion (GO:0046929)2.69170165
57folic acid-containing compound biosynthetic process (GO:0009396)2.69158921
58nucleotide-sugar biosynthetic process (GO:0009226)2.69153997
59iron ion import (GO:0097286)2.68061483
60succinate metabolic process (GO:0006105)2.67494100
61cellular response to unfolded protein (GO:0034620)2.67101563
62regulation of nuclease activity (GO:0032069)2.67012754
63sister chromatid segregation (GO:0000819)2.66996822
64surfactant homeostasis (GO:0043129)2.66218555
65apical protein localization (GO:0045176)2.65815356
66long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.63566592
67thioester biosynthetic process (GO:0035384)2.61919671
68acyl-CoA biosynthetic process (GO:0071616)2.61919671
69histone H2B ubiquitination (GO:0033523)2.61104703
70mitotic metaphase plate congression (GO:0007080)2.59763063
71biotin metabolic process (GO:0006768)2.59294815
72fatty-acyl-CoA biosynthetic process (GO:0046949)2.59286214
73cellular copper ion homeostasis (GO:0006878)2.58765144
74coenzyme catabolic process (GO:0009109)2.58009914
75protein localization to chromosome, centromeric region (GO:0071459)2.57690742
76positive regulation of keratinocyte differentiation (GO:0045618)2.57036438
77DNA duplex unwinding (GO:0032508)2.56499357
78regulation of glucose import in response to insulin stimulus (GO:2001273)2.56135702
79tRNA aminoacylation for protein translation (GO:0006418)2.55158924
80regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.55113046
81regulation of synaptic vesicle exocytosis (GO:2000300)2.54832925
82DNA strand elongation involved in DNA replication (GO:0006271)2.54750854
83presynaptic membrane organization (GO:0097090)2.53654754
84peptidyl-arginine omega-N-methylation (GO:0035247)2.53211493
85proline metabolic process (GO:0006560)2.53081374
86protein localization to microtubule (GO:0035372)2.52808568
87glutamate secretion (GO:0014047)2.52117780
88DNA strand elongation (GO:0022616)2.51873962
89aspartate family amino acid catabolic process (GO:0009068)2.51587981
90protein hydroxylation (GO:0018126)2.50840496
91positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.50258487
92positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.50249594
93regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.48921636
94mitotic nuclear envelope disassembly (GO:0007077)2.48834587
95cerebellar granule cell differentiation (GO:0021707)2.47205488
96regulation of centriole replication (GO:0046599)2.46553215
97vocalization behavior (GO:0071625)2.46397505
98gamma-aminobutyric acid signaling pathway (GO:0007214)2.44871579
99neurotransmitter catabolic process (GO:0042135)2.44257670
100regulation of acyl-CoA biosynthetic process (GO:0050812)2.43723688
101glutamate metabolic process (GO:0006536)2.43659823
102eye photoreceptor cell differentiation (GO:0001754)2.42766459
103photoreceptor cell differentiation (GO:0046530)2.42766459
104central nervous system myelination (GO:0022010)2.42357952
105axon ensheathment in central nervous system (GO:0032291)2.42357952
106nuclear envelope disassembly (GO:0051081)2.42165952
107membrane disassembly (GO:0030397)2.42165952
108gap junction assembly (GO:0016264)2.41833965
109dicarboxylic acid catabolic process (GO:0043649)2.41496305
110peptidyl-proline hydroxylation (GO:0019511)2.41442310
111tricarboxylic acid cycle (GO:0006099)2.41150271
112amino acid activation (GO:0043038)2.41070154
113tRNA aminoacylation (GO:0043039)2.41070154
114protein N-linked glycosylation via asparagine (GO:0018279)2.41013574
115adherens junction assembly (GO:0034333)2.40705653
116DNA geometric change (GO:0032392)2.39979035
117lysine catabolic process (GO:0006554)2.39968696
118lysine metabolic process (GO:0006553)2.39968696
119cellular response to topologically incorrect protein (GO:0035967)2.39863672
1204-hydroxyproline metabolic process (GO:0019471)2.39818461
121cell-substrate adherens junction assembly (GO:0007045)2.39809407
122focal adhesion assembly (GO:0048041)2.39809407
123pentose-phosphate shunt (GO:0006098)2.39726707
124peptidyl-asparagine modification (GO:0018196)2.39610862
125glutamine family amino acid biosynthetic process (GO:0009084)2.39087381
126epithelial cell-cell adhesion (GO:0090136)2.38679480
127aromatic amino acid family catabolic process (GO:0009074)2.37649975
128regulation of translational elongation (GO:0006448)2.37515750
129alpha-linolenic acid metabolic process (GO:0036109)2.36964814
130regulation of spindle organization (GO:0090224)2.36597549
131regulation of sister chromatid cohesion (GO:0007063)2.36585951
132urea cycle (GO:0000050)2.36352602
133detection of calcium ion (GO:0005513)2.36009585
134long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.35907363
135fatty-acyl-CoA metabolic process (GO:0035337)2.35876508
136regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.35828995
137chromosome condensation (GO:0030261)2.33497197
138regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.33465556
139synaptic vesicle maturation (GO:0016188)2.33413360
140cell-substrate junction assembly (GO:0007044)2.33305876
141regulation of cholesterol biosynthetic process (GO:0045540)2.32904434
142cellular zinc ion homeostasis (GO:0006882)2.32888238
143very-low-density lipoprotein particle assembly (GO:0034379)2.32709607
144short-chain fatty acid metabolic process (GO:0046459)2.32518998
145ribosome biogenesis (GO:0042254)2.31107649
146maternal placenta development (GO:0001893)2.30931323
147epithelial cell differentiation involved in prostate gland development (GO:0060742)2.30200859
148regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.29676684
149protein N-linked glycosylation (GO:0006487)2.28678274
150dicarboxylic acid biosynthetic process (GO:0043650)2.25252009
151neurotransmitter secretion (GO:0007269)2.25019937
152regulation of cofactor metabolic process (GO:0051193)2.24401489
153regulation of coenzyme metabolic process (GO:0051196)2.24401489
154NADH metabolic process (GO:0006734)2.22668342
155bile acid biosynthetic process (GO:0006699)2.21436843
156potassium ion import (GO:0010107)2.21121674
157protein localization to synapse (GO:0035418)2.20725575
158regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.20501727
159positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.19812365
160positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.19056508
161locomotory exploration behavior (GO:0035641)2.17069067
162glyoxylate metabolic process (GO:0046487)2.17038976
163asymmetric protein localization (GO:0008105)2.16902559
164cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.16395403
165neuron recognition (GO:0008038)2.15463126
166neuronal action potential propagation (GO:0019227)2.14873203
167very long-chain fatty acid metabolic process (GO:0000038)2.14210366
168protein targeting to Golgi (GO:0000042)2.14172729
169cellular potassium ion homeostasis (GO:0030007)2.14164328
170regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.14044443
171membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.13401858
172tyrosine metabolic process (GO:0006570)2.12963199
173transmission of nerve impulse (GO:0019226)2.12804769
174neurotransmitter-gated ion channel clustering (GO:0072578)2.11088953
175activation of protein kinase A activity (GO:0034199)2.10649613
176response to methylmercury (GO:0051597)2.10188660
177long-term synaptic potentiation (GO:0060291)2.09855148
178positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.09839489
179regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.08010952
180negative regulation of synaptic transmission, GABAergic (GO:0032229)2.07393355
181neuron-neuron synaptic transmission (GO:0007270)2.06994783
182negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.06795500
183dendrite morphogenesis (GO:0048813)2.06721774
184substantia nigra development (GO:0021762)2.06681084
185mating behavior (GO:0007617)2.06437845
186suckling behavior (GO:0001967)2.06181610
187negative regulation of protein activation cascade (GO:2000258)2.05115860
188behavioral response to cocaine (GO:0048148)2.04765972
189acetyl-CoA metabolic process (GO:0006084)2.04307313
190gamma-aminobutyric acid transport (GO:0015812)2.03857924
191neuromuscular junction development (GO:0007528)2.03681863
192regulation of sulfur metabolic process (GO:0042762)2.03570513
193regulation of voltage-gated calcium channel activity (GO:1901385)2.03190095
194regulation of synaptic vesicle transport (GO:1902803)2.02988377
195negative regulation of protein localization to cell surface (GO:2000009)2.02500822
196import into cell (GO:0098657)2.02116022
197myelination (GO:0042552)2.01353315

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.41262563
2AR_21909140_ChIP-Seq_LNCAP_Human3.68413763
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.63947774
4GBX2_23144817_ChIP-Seq_PC3_Human3.50856658
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.14757776
6ZNF263_19887448_ChIP-Seq_K562_Human3.14641409
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.98496947
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.97415218
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.96778467
10TAF15_26573619_Chip-Seq_HEK293_Human2.57938504
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.52721016
12EZH2_22144423_ChIP-Seq_EOC_Human2.52524214
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37655199
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.31669686
15ZFX_18555785_ChIP-Seq_MESCs_Mouse2.22955972
16MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21426737
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20544632
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.18781682
19PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.17449155
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.15370616
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.14471686
22* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.14063381
23* SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.13400538
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05454800
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.03825911
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02918180
27ESR1_15608294_ChIP-ChIP_MCF-7_Human2.01891427
28HIF1A_21447827_ChIP-Seq_MCF-7_Human2.01550403
29* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.98340057
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96867601
31AR_21572438_ChIP-Seq_LNCaP_Human1.96336589
32SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.96001142
33SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.95139407
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94276537
35TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93614812
36CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92114265
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.86495259
38* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.82317596
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.82058119
40SMAD4_21799915_ChIP-Seq_A2780_Human1.80350029
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.80334527
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.79185663
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.78491958
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.78489524
45SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78276051
46OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.78253810
47MTF2_20144788_ChIP-Seq_MESCs_Mouse1.77546229
48SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.77288932
49KLF4_18555785_ChIP-Seq_MESCs_Mouse1.77196841
50EZH2_18974828_ChIP-Seq_MESCs_Mouse1.76394813
51RNF2_18974828_ChIP-Seq_MESCs_Mouse1.76394813
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.76119829
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.73938619
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73139136
55* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.71016189
56DCP1A_22483619_ChIP-Seq_HELA_Human1.69484243
57CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69442543
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.67452861
59SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.67244026
60E2F1_21310950_ChIP-Seq_MCF-7_Human1.66854152
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.66078767
62PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64365987
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.63409739
64ESR2_21235772_ChIP-Seq_MCF-7_Human1.63286828
65P300_19829295_ChIP-Seq_ESCs_Human1.61667401
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.60840634
67E2F4_17652178_ChIP-ChIP_JURKAT_Human1.59229041
68ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55195822
69TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.55187643
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54692729
71TFEB_21752829_ChIP-Seq_HELA_Human1.54234880
72EZH2_27304074_Chip-Seq_ESCs_Mouse1.54177342
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53770945
74NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53770945
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.53506641
76SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.52808440
77CHD1_26751641_Chip-Seq_LNCaP_Human1.52565070
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.51889006
79NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.51440140
80LXR_22158963_ChIP-Seq_LIVER_Mouse1.51059258
81RXR_22158963_ChIP-Seq_LIVER_Mouse1.50587925
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49745775
83JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49235396
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48008738
85E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47812751
86FUS_26573619_Chip-Seq_HEK293_Human1.47416672
87PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46696928
88DROSHA_22980978_ChIP-Seq_HELA_Human1.46560585
89ER_23166858_ChIP-Seq_MCF-7_Human1.46292533
90* XRN2_22483619_ChIP-Seq_HELA_Human1.45812078
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.43723962
92* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.43664122
93RACK7_27058665_Chip-Seq_MCF-7_Human1.43398009
94ATF3_27146783_Chip-Seq_COLON_Human1.43385210
95CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.43057902
96NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.42683304
97EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.42319212
98STAT3_23295773_ChIP-Seq_U87_Human1.41826088
99KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40827024
100ESR1_20079471_ChIP-ChIP_T-47D_Human1.38425493
101STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37886282
102GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36232575
103SOX2_27498859_Chip-Seq_STOMACH_Mouse1.36208950
104ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.36206959
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.35285032
106* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34503270
107SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.34484979
108WT1_19549856_ChIP-ChIP_CCG9911_Human1.33879531
109ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33460582
110SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.33095158
111SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.33095158
112ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31360059
113ZNF274_21170338_ChIP-Seq_K562_Hela1.30668687
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30646183
115EZH2_27294783_Chip-Seq_ESCs_Mouse1.30167886
116ARNT_22903824_ChIP-Seq_MCF-7_Human1.29708238
117NANOG_18555785_ChIP-Seq_MESCs_Mouse1.28243954
118* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28201969
119REST_21632747_ChIP-Seq_MESCs_Mouse1.27463769
120RARB_27405468_Chip-Seq_BRAIN_Mouse1.27215030
121CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.26950853
122ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.26620620
123CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24452212
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24308834
125BCAT_22108803_ChIP-Seq_LS180_Human1.23548172
126THAP11_20581084_ChIP-Seq_MESCs_Mouse1.23323163
127JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.23134671
128AHR_22903824_ChIP-Seq_MCF-7_Human1.22700307
129TP53_16413492_ChIP-PET_HCT116_Human1.22593287
130* GATA6_25053715_ChIP-Seq_YYC3_Human1.22501893
131NR3C1_21868756_ChIP-Seq_MCF10A_Human1.22140563
132TCF4_23295773_ChIP-Seq_U87_Human1.21745254
133AR_25329375_ChIP-Seq_VCAP_Human1.21559544
134NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20753483
135KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.19687434
136NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.17711100
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.17522583
138P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16992082
139SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16421410
140FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.16014074
141SOX17_20123909_ChIP-Seq_XEN_Mouse1.15863382
142RNF2_27304074_Chip-Seq_ESCs_Mouse1.15396894
143* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14116475
144HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13686509
145* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.11807500
146GABP_19822575_ChIP-Seq_HepG2_Human1.11027167
147NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10725266
148BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10710895
149TP53_18474530_ChIP-ChIP_U2OS_Human1.10535219
150FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.10277559
151KDM5A_27292631_Chip-Seq_BREAST_Human1.09720705
152REST_18959480_ChIP-ChIP_MESCs_Mouse1.08783659
153TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08670419
154MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08465634
155RUNX2_22187159_ChIP-Seq_PCA_Human1.08380411
156FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07695692
157KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07489154
158TRIM28_21343339_ChIP-Seq_HEK293_Human1.07378770
159* GATA3_24758297_ChIP-Seq_MCF-7_Human1.07330353
160HTT_18923047_ChIP-ChIP_STHdh_Human1.06561405
161TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.06318685
162RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04935712
163PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04817688
164AR_19668381_ChIP-Seq_PC3_Human1.03809167
165MYC_22102868_ChIP-Seq_BL_Human1.02915260
166FOXA2_19822575_ChIP-Seq_HepG2_Human1.02378122
167NANOG_21062744_ChIP-ChIP_HESCs_Human1.02131739
168RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01963362
169RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01565929
170WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.01212739
171TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99880907
172TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99165792
173GATA4_21415370_ChIP-Seq_HL-1_Mouse0.98255759
174TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97992374
175CBP_20019798_ChIP-Seq_JUKART_Human0.97973443
176IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97973443
177ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97873967
178PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97690981
179* TTF2_22483619_ChIP-Seq_HELA_Human0.97689561
180YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97667812
181TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97333086
182SMAD4_21741376_ChIP-Seq_HESCs_Human0.97171396
183CLOCK_20551151_ChIP-Seq_293T_Human0.97097480
184SMAD4_21741376_ChIP-Seq_EPCs_Human0.97085842
185WT1_25993318_ChIP-Seq_PODOCYTE_Human0.96693186
186* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96324087
187UBF1/2_26484160_Chip-Seq_HMECs_Human0.96297363
188NANOG_18555785_Chip-Seq_ESCs_Mouse0.96234508
189PPARA_22158963_ChIP-Seq_LIVER_Mouse0.96230173
190PRDM14_20953172_ChIP-Seq_ESCs_Human0.95445901
191TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.95078822
192TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93716924
193BMI1_23680149_ChIP-Seq_NPCS_Mouse0.93087719
194RUNX1_27514584_Chip-Seq_MCF-7_Human0.92647098

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.58694709
2MP0002877_abnormal_melanocyte_morpholog3.94472407
3MP0003705_abnormal_hypodermis_morpholog3.26161111
4MP0010352_gastrointestinal_tract_polyps3.01557090
5MP0005451_abnormal_body_composition2.70265715
6MP0002837_dystrophic_cardiac_calcinosis2.62997841
7MP0004957_abnormal_blastocyst_morpholog2.59876136
8MP0003880_abnormal_central_pattern2.57636957
9MP0002139_abnormal_hepatobiliary_system2.56315909
10MP0004264_abnormal_extraembryonic_tissu2.56294046
11MP0004270_analgesia2.55443453
12MP0003941_abnormal_skin_development2.54927246
13MP0004233_abnormal_muscle_weight2.53271174
14MP0003693_abnormal_embryo_hatching2.51792658
15MP0002796_impaired_skin_barrier2.50072414
16MP0004859_abnormal_synaptic_plasticity2.49411068
17MP0008875_abnormal_xenobiotic_pharmacok2.43656261
18MP0003566_abnormal_cell_adhesion2.35717689
19MP0005360_urolithiasis2.21043822
20MP0009780_abnormal_chondrocyte_physiolo2.18661951
21MP0003111_abnormal_nucleus_morphology2.17672492
22MP0003635_abnormal_synaptic_transmissio2.16612387
23MP0005085_abnormal_gallbladder_physiolo2.14384181
24MP0005076_abnormal_cell_differentiation2.12207329
25MP0003329_amyloid_beta_deposits2.04781867
26MP0009046_muscle_twitch1.96220647
27MP0009745_abnormal_behavioral_response1.96161781
28MP0000751_myopathy1.95954505
29MP0002064_seizures1.95941644
30MP0005365_abnormal_bile_salt1.92781257
31MP0004185_abnormal_adipocyte_glucose1.89976602
32MP0004782_abnormal_surfactant_physiolog1.89852916
33MP0005551_abnormal_eye_electrophysiolog1.88192602
34MP0010094_abnormal_chromosome_stability1.87700162
35MP0004036_abnormal_muscle_relaxation1.83142693
36MP0001730_embryonic_growth_arrest1.82827928
37MP0002272_abnormal_nervous_system1.82758675
38MP0005501_abnormal_skin_physiology1.82271201
39MP0004043_abnormal_pH_regulation1.79857997
40MP0005058_abnormal_lysosome_morphology1.79023275
41MP0003195_calcinosis1.75405597
42MP0008057_abnormal_DNA_replication1.74117706
43MP0000920_abnormal_myelination1.73510638
44MP0005257_abnormal_intraocular_pressure1.73145368
45MP0004130_abnormal_muscle_cell1.71659420
46MP0002909_abnormal_adrenal_gland1.70736719
47MP0002063_abnormal_learning/memory/cond1.69473079
48MP0002060_abnormal_skin_morphology1.68919094
49MP0000579_abnormal_nail_morphology1.67708560
50MP0008438_abnormal_cutaneous_collagen1.67671785
51MP0004084_abnormal_cardiac_muscle1.65738056
52MP0008932_abnormal_embryonic_tissue1.64626438
53MP0001968_abnormal_touch/_nociception1.62906437
54MP0005408_hypopigmentation1.61922823
55MP0000537_abnormal_urethra_morphology1.60757920
56MP0003077_abnormal_cell_cycle1.58135844
57MP0003690_abnormal_glial_cell1.58104086
58MP0002734_abnormal_mechanical_nocicepti1.57667888
59MP0001486_abnormal_startle_reflex1.57511127
60MP0000013_abnormal_adipose_tissue1.54683374
61MP0000747_muscle_weakness1.52329018
62MP0001529_abnormal_vocalization1.51875109
63MP0002572_abnormal_emotion/affect_behav1.51724332
64MP0003453_abnormal_keratinocyte_physiol1.50932645
65MP0004215_abnormal_myocardial_fiber1.50559052
66MP0004145_abnormal_muscle_electrophysio1.49814881
67MP0001440_abnormal_grooming_behavior1.48868652
68MP0000627_abnormal_mammary_gland1.43684651
69MP0010678_abnormal_skin_adnexa1.43025320
70MP0008260_abnormal_autophagy1.42299791
71MP0002736_abnormal_nociception_after1.41547208
72MP0009697_abnormal_copulation1.39488041
73MP0003191_abnormal_cellular_cholesterol1.39006905
74MP0002009_preneoplasia1.37965983
75MP0000350_abnormal_cell_proliferation1.37694444
76MP0005386_behavior/neurological_phenoty1.36224225
77MP0004924_abnormal_behavior1.36224225
78MP0002067_abnormal_sensory_capabilities1.32957555
79MP0001672_abnormal_embryogenesis/_devel1.32832436
80MP0005380_embryogenesis_phenotype1.32832436
81MP0009840_abnormal_foam_cell1.30385652
82MP0003984_embryonic_growth_retardation1.30290809
83MP0001299_abnormal_eye_distance/1.28408370
84MP0005646_abnormal_pituitary_gland1.28284036
85MP0000749_muscle_degeneration1.27348185
86MP0001849_ear_inflammation1.27197734
87MP0002090_abnormal_vision1.26334662
88MP0005332_abnormal_amino_acid1.26258690
89MP0001727_abnormal_embryo_implantation1.26179565
90MP0002735_abnormal_chemical_nociception1.25941527
91MP0001216_abnormal_epidermal_layer1.25661827
92MP0002098_abnormal_vibrissa_morphology1.24844529
93MP0002088_abnormal_embryonic_growth/wei1.24174551
94MP0001881_abnormal_mammary_gland1.24006691
95MP0006072_abnormal_retinal_apoptosis1.23279198
96* MP0002080_prenatal_lethality1.22080317
97MP0002229_neurodegeneration1.20588505
98MP0008007_abnormal_cellular_replicative1.20500128
99MP0001697_abnormal_embryo_size1.19828734
100MP0002086_abnormal_extraembryonic_tissu1.19714992
101MP0003221_abnormal_cardiomyocyte_apopto1.19163837
102MP0004085_abnormal_heartbeat1.18670245
103MP0009672_abnormal_birth_weight1.17629976
104MP0010329_abnormal_lipoprotein_level1.15949243
105MP0000377_abnormal_hair_follicle1.15579917
106MP0005330_cardiomyopathy1.15089766
107MP0003252_abnormal_bile_duct1.14865123
108MP0005620_abnormal_muscle_contractility1.14784067
109MP0001905_abnormal_dopamine_level1.13721106
110MP0004142_abnormal_muscle_tone1.12663531
111MP0004885_abnormal_endolymph1.12395761
112MP0001177_atelectasis1.11907272
113MP0003122_maternal_imprinting1.10634487
114MP0005409_darkened_coat_color1.10246275
115MP0003950_abnormal_plasma_membrane1.09485206
116MP0005666_abnormal_adipose_tissue1.06810664
117MP0000762_abnormal_tongue_morphology1.06734475
118MP0004858_abnormal_nervous_system1.06252838
119MP0003806_abnormal_nucleotide_metabolis1.05819163
120MP0002972_abnormal_cardiac_muscle1.05670012
121MP0001984_abnormal_olfaction1.05521731
122MP0005083_abnormal_biliary_tract1.04731066
123MP0000604_amyloidosis1.04341971
124MP0004272_abnormal_basement_membrane1.04081485
125MP0000778_abnormal_nervous_system1.02870444
126MP0002733_abnormal_thermal_nociception1.02653451
127MP0001501_abnormal_sleep_pattern1.02453131
128MP0006276_abnormal_autonomic_nervous1.02384367
129MP0002118_abnormal_lipid_homeostasis1.01561091
130MP0010307_abnormal_tumor_latency1.00694399
131MP0002896_abnormal_bone_mineralization0.98976747
132MP0001970_abnormal_pain_threshold0.98799509
133MP0003634_abnormal_glial_cell0.98768231
134* MP0005621_abnormal_cell_physiology0.98731293
135MP0003632_abnormal_nervous_system0.97339182
136MP0003123_paternal_imprinting0.96566930
137MP0002084_abnormal_developmental_patter0.96335134
138MP0003633_abnormal_nervous_system0.96113417
139MP0004484_altered_response_of0.94999241
140MP0000467_abnormal_esophagus_morphology0.94344389
141MP0002066_abnormal_motor_capabilities/c0.93853354
142MP0005623_abnormal_meninges_morphology0.93036584
143MP0002882_abnormal_neuron_morphology0.92907481
144MP0004087_abnormal_muscle_fiber0.92502571
145MP0003631_nervous_system_phenotype0.92325562
146MP0001661_extended_life_span0.92302364
147MP0004147_increased_porphyrin_level0.92213919
148MP0003656_abnormal_erythrocyte_physiolo0.91562202
149MP0001666_abnormal_nutrient_absorption0.90584404
150MP0004197_abnormal_fetal_growth/weight/0.89285918
151MP0010630_abnormal_cardiac_muscle0.88802041
152MP0002269_muscular_atrophy0.87893147
153MP0000003_abnormal_adipose_tissue0.87577327
154MP0002876_abnormal_thyroid_physiology0.87237620
155* MP0005384_cellular_phenotype0.87229428
156MP0002085_abnormal_embryonic_tissue0.86206988
157MP0010771_integument_phenotype0.86013639
158MP0009384_cardiac_valve_regurgitation0.85221882
159MP0002108_abnormal_muscle_morphology0.85167411
160MP0005375_adipose_tissue_phenotype0.84894839
161MP0002184_abnormal_innervation0.84368262
162MP0005535_abnormal_body_temperature0.84350400
163MP0000358_abnormal_cell_content/0.83778861
164MP0003868_abnormal_feces_composition0.83475937
165MP0005253_abnormal_eye_physiology0.82645482
166MP0001502_abnormal_circadian_rhythm0.82044699
167MP0005187_abnormal_penis_morphology0.81620020
168MP0000639_abnormal_adrenal_gland0.81221153
169MP0002557_abnormal_social/conspecific_i0.81201606
170MP0008569_lethality_at_weaning0.81131286
171MP0003137_abnormal_impulse_conducting0.80906433
172MP0000955_abnormal_spinal_cord0.80690547
173MP0003315_abnormal_perineum_morphology0.80514184
174MP0003091_abnormal_cell_migration0.79550818
175MP0001915_intracranial_hemorrhage0.78040690
176MP0003183_abnormal_peptide_metabolism0.78001058
177MP0002697_abnormal_eye_size0.75682111
178MP0000678_abnormal_parathyroid_gland0.74777776
179MP0000462_abnormal_digestive_system0.74332004
180MP0005023_abnormal_wound_healing0.72830329
181MP0005248_abnormal_Harderian_gland0.71954130
182MP0005275_abnormal_skin_tensile0.68225403
183MP0009931_abnormal_skin_appearance0.67309114

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)3.39013503
2Atonic seizures (HP:0010819)3.21230397
3Pheochromocytoma (HP:0002666)3.12636613
4Hyperventilation (HP:0002883)3.03199048
5Neurofibrillary tangles (HP:0002185)2.96408907
6Deep venous thrombosis (HP:0002625)2.90315880
7Cerebral inclusion bodies (HP:0100314)2.89532042
8Degeneration of the lateral corticospinal tracts (HP:0002314)2.87971017
9Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.87971017
10Exercise-induced myalgia (HP:0003738)2.79430759
11Insidious onset (HP:0003587)2.76505492
12Termporal pattern (HP:0011008)2.76505492
13Central scotoma (HP:0000603)2.73760936
14Back pain (HP:0003418)2.67774386
15Intrahepatic cholestasis (HP:0001406)2.67742466
16Ankyloglossia (HP:0010296)2.65246928
17Abnormality of aromatic amino acid family metabolism (HP:0004338)2.63842307
18Insomnia (HP:0100785)2.62905147
19Sensory axonal neuropathy (HP:0003390)2.59078283
20Neuroendocrine neoplasm (HP:0100634)2.56475433
21Epileptic encephalopathy (HP:0200134)2.55452287
22Ketoacidosis (HP:0001993)2.55108466
23Premature rupture of membranes (HP:0001788)2.54638920
24Absence seizures (HP:0002121)2.54432781
25Asymmetry of the thorax (HP:0001555)2.53407194
26Microglossia (HP:0000171)2.52892069
27Abnormality of glycolysis (HP:0004366)2.47482904
28Increased serum pyruvate (HP:0003542)2.47482904
29Osteolytic defects of the phalanges of the hand (HP:0009771)2.46106990
30Osteolytic defects of the hand bones (HP:0009699)2.46106990
31Hyperacusis (HP:0010780)2.45868584
32Flat acetabular roof (HP:0003180)2.45805333
33Abnormality of the corticospinal tract (HP:0002492)2.42555263
34Focal seizures (HP:0007359)2.41172141
35Action tremor (HP:0002345)2.40481914
36Hyporeflexia of lower limbs (HP:0002600)2.38000104
37Exercise-induced muscle cramps (HP:0003710)2.37719526
38Dysdiadochokinesis (HP:0002075)2.33257921
39Muscle hypertrophy of the lower extremities (HP:0008968)2.29413651
40Visual hallucinations (HP:0002367)2.28156691
41Congenital stationary night blindness (HP:0007642)2.28028642
42Deviation of the thumb (HP:0009603)2.27294192
43Septate vagina (HP:0001153)2.27288133
44Selective tooth agenesis (HP:0001592)2.25983942
45Ketosis (HP:0001946)2.24970229
46Infantile muscular hypotonia (HP:0008947)2.22248225
47Dysmetria (HP:0001310)2.22187895
48Scanning speech (HP:0002168)2.21973358
49Advanced eruption of teeth (HP:0006288)2.21956476
50Calf muscle hypertrophy (HP:0008981)2.18816887
51Vertebral compression fractures (HP:0002953)2.17728425
52Intention tremor (HP:0002080)2.17368733
53Dialeptic seizures (HP:0011146)2.17060300
54Generalized tonic-clonic seizures (HP:0002069)2.16592880
55Anxiety (HP:0000739)2.15946227
56Progressive muscle weakness (HP:0003323)2.15743578
57Abnormality of oral frenula (HP:0000190)2.15554360
58Increased connective tissue (HP:0009025)2.14327803
59Cholecystitis (HP:0001082)2.13770129
60Abnormal gallbladder physiology (HP:0012438)2.13770129
61Multiple enchondromatosis (HP:0005701)2.12632485
62Hyperlipoproteinemia (HP:0010980)2.11888119
63J-shaped sella turcica (HP:0002680)2.07572462
64Papillary thyroid carcinoma (HP:0002895)2.07370557
65Proximal placement of thumb (HP:0009623)2.06652363
66Pili torti (HP:0003777)2.03959687
67Abnormality of the distal phalanges of the toes (HP:0010182)2.02915593
68Spastic gait (HP:0002064)2.02254637
69Short nail (HP:0001799)2.02146073
70Myokymia (HP:0002411)2.01374631
71Orthostatic hypotension (HP:0001278)2.00799741
72Drooling (HP:0002307)2.00295786
73Excessive salivation (HP:0003781)2.00295786
74Sudden death (HP:0001699)2.00182120
75Abnormality of the calf musculature (HP:0001430)1.99862181
76Sparse lateral eyebrow (HP:0005338)1.99061044
77Progressive external ophthalmoplegia (HP:0000590)1.99026776
78Deep philtrum (HP:0002002)1.96418456
79Increased nuchal translucency (HP:0010880)1.95862135
80Hypoglycemic coma (HP:0001325)1.95560001
81Myoglobinuria (HP:0002913)1.95402131
82Blue irides (HP:0000635)1.95250876
83Acute encephalopathy (HP:0006846)1.95093283
84Cerebral edema (HP:0002181)1.94268188
85Protrusio acetabuli (HP:0003179)1.94040468
86Impaired vibration sensation in the lower limbs (HP:0002166)1.93686379
87Xanthomatosis (HP:0000991)1.93013918
88Trismus (HP:0000211)1.92971557
89Abnormality of the intrinsic pathway (HP:0010989)1.92752406
90Epileptiform EEG discharges (HP:0011182)1.92173829
91Abnormal gallbladder morphology (HP:0012437)1.92020954
92Oligomenorrhea (HP:0000876)1.91942292
93Ragged-red muscle fibers (HP:0003200)1.91812612
94Abnormality of the umbilical cord (HP:0010881)1.91368156
95Hypokinesia (HP:0002375)1.91177619
96Achilles tendon contracture (HP:0001771)1.90797414
97Abnormality of macular pigmentation (HP:0008002)1.90642491
98Syncope (HP:0001279)1.90298006
99Abnormality of the gastric mucosa (HP:0004295)1.89596679
100Unilateral renal agenesis (HP:0000122)1.89126271
101Abnormal foot bone ossification (HP:0010675)1.88985618
102Truncal ataxia (HP:0002078)1.88555684
103Postural tremor (HP:0002174)1.88469704
104Cerebral hemorrhage (HP:0001342)1.87701421
105Onycholysis (HP:0001806)1.87437192
106Overlapping toe (HP:0001845)1.87250760
107Broad-based gait (HP:0002136)1.87111418
108Abnormal mitochondria in muscle tissue (HP:0008316)1.86740989
109EEG with generalized epileptiform discharges (HP:0011198)1.86096778
110Abnormality of the Achilles tendon (HP:0005109)1.85950109
111Gout (HP:0001997)1.85131443
112Hyperparathyroidism (HP:0000843)1.84915747
113Autoamputation (HP:0001218)1.84617662
114Abnormal cartilage morphology (HP:0002763)1.84528378
115Hypobetalipoproteinemia (HP:0003563)1.83624196
116Agitation (HP:0000713)1.83329372
117Chromsome breakage (HP:0040012)1.81835389
118Muscle fiber splitting (HP:0003555)1.81461783
119Distal lower limb amyotrophy (HP:0008944)1.81062739
120Centrally nucleated skeletal muscle fibers (HP:0003687)1.80503837
121Acute necrotizing encephalopathy (HP:0006965)1.79802729
122Progressive macrocephaly (HP:0004481)1.79519129
123Supranuclear gaze palsy (HP:0000605)1.78138698
124Hypsarrhythmia (HP:0002521)1.77996191
125Natal tooth (HP:0000695)1.77508667
126Fasciculations (HP:0002380)1.76760607
127Abnormal tarsal ossification (HP:0008369)1.76687127
128Abnormality of carpal bone ossification (HP:0006257)1.76439584
129Cholelithiasis (HP:0001081)1.76115149
130Abnormality of nail color (HP:0100643)1.75029568
131Breech presentation (HP:0001623)1.74459834
132Curly hair (HP:0002212)1.74079344
133Abnormality of the ischium (HP:0003174)1.74067935
134Scotoma (HP:0000575)1.73348774
135Chromosomal breakage induced by crosslinking agents (HP:0003221)1.72769108
136Resting tremor (HP:0002322)1.72580292
137Micronodular cirrhosis (HP:0001413)1.72297051
138Sensorimotor neuropathy (HP:0007141)1.71950998
139Febrile seizures (HP:0002373)1.71907809
140Skin nodule (HP:0200036)1.71121650
141Reticulocytosis (HP:0001923)1.70938665
142Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.70847650
143Hypoplastic ischia (HP:0003175)1.70735945
144Abnormality of monocarboxylic acid metabolism (HP:0010996)1.69822944
145Progressive cerebellar ataxia (HP:0002073)1.69110791
146Generalized myoclonic seizures (HP:0002123)1.68663623
147Tetraparesis (HP:0002273)1.68512957
148Right ventricular cardiomyopathy (HP:0011663)1.68275127
149Ulnar bowing (HP:0003031)1.67682647
150Urinary urgency (HP:0000012)1.67440915
151Missing ribs (HP:0000921)1.67347285
152Gaze-evoked nystagmus (HP:0000640)1.67248115
153Distal upper limb amyotrophy (HP:0007149)1.66994994
154Upper limb amyotrophy (HP:0009129)1.66994994
155Hammertoe (HP:0001765)1.66820472
156EMG: myopathic abnormalities (HP:0003458)1.66516942
157Atrophic scars (HP:0001075)1.66474825
158Increased variability in muscle fiber diameter (HP:0003557)1.66125502
159Distal lower limb muscle weakness (HP:0009053)1.66022749
160Poor speech (HP:0002465)1.65753297
161Abnormalities of placenta or umbilical cord (HP:0001194)1.65236311
162Prolonged QT interval (HP:0001657)1.64921591
163Neonatal death (HP:0003811)1.64784862
164Hypoglycemic seizures (HP:0002173)1.64399202
165Spastic diplegia (HP:0001264)1.64164696
166Overriding aorta (HP:0002623)1.63716015
167Spinal cord compression (HP:0002176)1.62992816
168Complement deficiency (HP:0004431)1.62091568
169Impaired pain sensation (HP:0007328)1.61449987
170Abnormality of pain sensation (HP:0010832)1.61449987
171Abnormality of the common coagulation pathway (HP:0010990)1.60815025
172Dysmetric saccades (HP:0000641)1.60807433
173Rimmed vacuoles (HP:0003805)1.59979286
174Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.59005517
175Hyperammonemia (HP:0001987)1.58711254
176Palpitations (HP:0001962)1.58700975
177Hyperglycemia (HP:0003074)1.58643540
178Progressive hearing impairment (HP:0001730)1.58631316
179Spinal rigidity (HP:0003306)1.58319300
180Vertebral arch anomaly (HP:0008438)1.58179545
181Abnormal umbilical cord blood vessels (HP:0011403)1.57666085
182Single umbilical artery (HP:0001195)1.57666085
183Abnormality of the fetal cardiovascular system (HP:0010948)1.57666085
184Pseudobulbar signs (HP:0002200)1.57390896

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SCYL24.30168293
2STK393.10164078
3MST1R3.08586087
4EIF2AK13.01242178
5CDK123.00025024
6EPHA22.75855626
7OXSR12.60191403
8PBK2.46723041
9CASK2.44405979
10NTRK32.43580772
11EEF2K2.34895116
12SMG12.27479861
13TRIB32.20537439
14NME22.18951206
15LATS22.15709670
16MAP3K42.02527475
17PLK22.00669338
18WNK42.00480146
19TTK1.99444690
20ICK1.95499046
21IRAK31.94395693
22SRPK11.93351829
23TSSK61.85760301
24BCR1.79335554
25RPS6KB21.77657091
26FGFR21.76976167
27PNCK1.70546419
28PAK31.67918530
29PDGFRA1.64732346
30RIPK11.63140207
31MAP2K41.63115028
32PAK41.60609435
33NTRK11.56274385
34EPHA41.55830181
35FRK1.54872264
36PIK3CA1.54832164
37FGFR41.50788652
38TESK11.49591851
39LATS11.48832250
40INSRR1.48007138
41CAMK1G1.45263221
42SIK11.45025619
43SGK2231.43684847
44SGK4941.43684847
45MST41.42834292
46MAP3K121.41722736
47AKT31.41104074
48EIF2AK31.39899907
49MAP3K91.39251253
50PAK61.35155764
51PHKG21.33589889
52PHKG11.33589889
53WNK11.31106951
54OBSCN1.28542311
55BUB11.26588393
56PDK31.25443736
57PDK41.25443736
58MARK11.22983697
59NEK11.22711515
60CAMK2D1.22164873
61MET1.21226593
62MINK11.20064386
63ARAF1.19970541
64CAMK2B1.19430706
65CDC71.18176133
66EPHB11.17122166
67CSNK1G21.16472738
68CAMK2A1.14436621
69PRPF4B1.11782677
70GRK71.11170178
71PKN21.09418414
72ALK1.08194886
73MAP2K71.07675723
74TTN1.05283507
75PRKCE1.05139629
76BRD41.04320380
77CSNK1A1L1.02998454
78CAMKK21.01159904
79CSNK1G31.00659693
80MTOR1.00141432
81FER1.00068075
82CDK70.98149800
83MYLK0.98112108
84ERN10.96283649
85ERBB40.95352872
86ROCK20.94990820
87TAOK30.93305358
88CAMK2G0.92672132
89MAP3K20.91938408
90LMTK20.91453584
91SGK20.91396487
92KSR20.91153291
93CDK60.89308830
94CSNK1G10.86612990
95CDK50.85861662
96NME10.85454699
97PKN10.84181199
98MAP3K80.83196225
99NEK60.81332451
100TNIK0.80817118
101RET0.79769988
102PRKCH0.78039852
103CAMK1D0.77607777
104SGK30.77579795
105MAPKAPK30.76689406
106PTK2B0.76112723
107LIMK10.76070843
108CDK190.74733059
109GRK50.73973804
110AKT20.72032175
111PRKCG0.71186647
112CHEK10.69816193
113WEE10.69017715
114AURKB0.66375906
115DMPK0.65619628
116PIM20.65002636
117BRSK10.63469220
118MAPKAPK50.63216389
119MAP3K70.63093799
120MAP2K10.62911707
121ADRBK10.61940616
122DDR20.61471385
123EIF2AK20.61007500
124PIK3CG0.59178693
125ROCK10.58963530
126UHMK10.58506281
127PDPK10.58484530
128SGK10.58309141
129PLK10.58298612
130CLK10.58058377
131PDK20.57615970
132MAP3K130.56014215
133KSR10.55916168
134ERBB30.55600372
135PDGFRB0.55585506
136RPS6KA40.55135831
137PAK20.55090978
138STK100.54723414
139RAF10.54255525
140PRKG10.54187711
141DAPK20.53101693
142NEK90.52964707
143SIK30.52886619
144WNK30.52759902
145PRKD10.52750165
146PRKACB0.52319983
147PTK20.52137942
148BRAF0.52044047
149CDC42BPA0.50328234
150CSNK1E0.50269336
151PRKD30.50133337
152CDK140.49789971
153NTRK20.49594611
154RPS6KB10.49053935
155PRKCQ0.48016844
156TRPM70.46821437
157FGFR10.45385892
158CHEK20.45081301
159LRRK20.44516721
160MAP3K30.44452504
161PTK60.44315635
162ATR0.43293094
163CDK10.42168722
164MAP3K140.40942413
165AURKA0.40935377
166CDK80.40437610
167CDK90.40357655
168CDK20.37651140
169PRKCI0.37364612
170CDK180.36789195
171MAP3K10.36124287
172MKNK10.35578685
173FGFR30.35284074
174PLK30.35187650

Predicted pathways (KEGG)

RankGene SetZ-score
1Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.74371892
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.47172584
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.32872489
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.19697043
5Nitrogen metabolism_Homo sapiens_hsa009102.19459736
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.17004130
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.13975545
8Butanoate metabolism_Homo sapiens_hsa006502.11364997
9Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.09269292
10Thyroid cancer_Homo sapiens_hsa052162.00338942
11DNA replication_Homo sapiens_hsa030301.91366012
12Sulfur metabolism_Homo sapiens_hsa009201.88677756
13Propanoate metabolism_Homo sapiens_hsa006401.87440979
14Fatty acid elongation_Homo sapiens_hsa000621.86643775
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.82971064
16Nicotine addiction_Homo sapiens_hsa050331.80256526
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75910775
18Pentose phosphate pathway_Homo sapiens_hsa000301.67578180
19Fructose and mannose metabolism_Homo sapiens_hsa000511.67332791
20Fatty acid metabolism_Homo sapiens_hsa012121.60169422
21Central carbon metabolism in cancer_Homo sapiens_hsa052301.58873765
22GABAergic synapse_Homo sapiens_hsa047271.56074021
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54616713
24Synaptic vesicle cycle_Homo sapiens_hsa047211.54144027
25Pyruvate metabolism_Homo sapiens_hsa006201.52134527
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50336013
27Vitamin B6 metabolism_Homo sapiens_hsa007501.49443078
28Fatty acid degradation_Homo sapiens_hsa000711.49120022
29Arginine biosynthesis_Homo sapiens_hsa002201.48663248
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47407178
31Proteasome_Homo sapiens_hsa030501.44925092
32Other glycan degradation_Homo sapiens_hsa005111.41186110
33Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.41068370
34RNA transport_Homo sapiens_hsa030131.40460466
35Bladder cancer_Homo sapiens_hsa052191.37802727
36Phototransduction_Homo sapiens_hsa047441.37392897
37Galactose metabolism_Homo sapiens_hsa000521.36565447
38Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.36070032
39Adherens junction_Homo sapiens_hsa045201.32297550
40Spliceosome_Homo sapiens_hsa030401.31093601
41Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.30989934
42Mismatch repair_Homo sapiens_hsa034301.27153785
43Oxidative phosphorylation_Homo sapiens_hsa001901.26078806
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.26038123
45Cell cycle_Homo sapiens_hsa041101.25796531
46Tryptophan metabolism_Homo sapiens_hsa003801.24608909
47N-Glycan biosynthesis_Homo sapiens_hsa005101.23128620
48Non-homologous end-joining_Homo sapiens_hsa034501.22793037
49Collecting duct acid secretion_Homo sapiens_hsa049661.22659763
50Circadian entrainment_Homo sapiens_hsa047131.20248215
51One carbon pool by folate_Homo sapiens_hsa006701.19844117
52mRNA surveillance pathway_Homo sapiens_hsa030151.18038239
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.15911611
54Insulin secretion_Homo sapiens_hsa049111.14320935
55Cyanoamino acid metabolism_Homo sapiens_hsa004601.09461791
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.09003138
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08486695
58Chronic myeloid leukemia_Homo sapiens_hsa052201.08088900
59Cardiac muscle contraction_Homo sapiens_hsa042601.07428731
60Morphine addiction_Homo sapiens_hsa050321.07110634
61Prion diseases_Homo sapiens_hsa050201.06551728
62Glutamatergic synapse_Homo sapiens_hsa047241.06460621
63Renin secretion_Homo sapiens_hsa049241.04912849
64Amphetamine addiction_Homo sapiens_hsa050311.04371212
65Bile secretion_Homo sapiens_hsa049761.03040092
66Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01848157
67Long-term potentiation_Homo sapiens_hsa047201.01466898
68Dopaminergic synapse_Homo sapiens_hsa047281.01127463
69Steroid biosynthesis_Homo sapiens_hsa001001.00636981
70Peroxisome_Homo sapiens_hsa041461.00030341
71Vibrio cholerae infection_Homo sapiens_hsa051100.99774458
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98389201
73Alzheimers disease_Homo sapiens_hsa050100.98156930
74Nucleotide excision repair_Homo sapiens_hsa034200.97077410
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.96592755
76Salivary secretion_Homo sapiens_hsa049700.95722546
77Pancreatic cancer_Homo sapiens_hsa052120.95259606
78PPAR signaling pathway_Homo sapiens_hsa033200.93550643
79Taste transduction_Homo sapiens_hsa047420.93464269
80Dilated cardiomyopathy_Homo sapiens_hsa054140.92338757
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.92172690
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91967647
83Serotonergic synapse_Homo sapiens_hsa047260.91670501
84Carbon metabolism_Homo sapiens_hsa012000.91609836
85Tyrosine metabolism_Homo sapiens_hsa003500.90496451
86Endometrial cancer_Homo sapiens_hsa052130.90136779
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89991354
88Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89063631
89Olfactory transduction_Homo sapiens_hsa047400.88947417
90Gastric acid secretion_Homo sapiens_hsa049710.88506057
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.87988070
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.87843734
93Proteoglycans in cancer_Homo sapiens_hsa052050.87001529
94Phenylalanine metabolism_Homo sapiens_hsa003600.84465304
95Sphingolipid metabolism_Homo sapiens_hsa006000.84395967
96Long-term depression_Homo sapiens_hsa047300.83194120
97Histidine metabolism_Homo sapiens_hsa003400.83144294
98Complement and coagulation cascades_Homo sapiens_hsa046100.82345302
99AMPK signaling pathway_Homo sapiens_hsa041520.82198021
100Parkinsons disease_Homo sapiens_hsa050120.82162314
101Insulin signaling pathway_Homo sapiens_hsa049100.81209256
102Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80219587
103Renal cell carcinoma_Homo sapiens_hsa052110.80073181
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.79350132
105Cocaine addiction_Homo sapiens_hsa050300.79253450
106Small cell lung cancer_Homo sapiens_hsa052220.79208201
107Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77791350
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.77445671
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75215522
110beta-Alanine metabolism_Homo sapiens_hsa004100.75041607
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74957094
112Cholinergic synapse_Homo sapiens_hsa047250.74657741
113Steroid hormone biosynthesis_Homo sapiens_hsa001400.72323140
114Tight junction_Homo sapiens_hsa045300.71447029
115Starch and sucrose metabolism_Homo sapiens_hsa005000.71079221
116Folate biosynthesis_Homo sapiens_hsa007900.70964988
117Non-small cell lung cancer_Homo sapiens_hsa052230.70175745
118Chemical carcinogenesis_Homo sapiens_hsa052040.70070808
119Lysine degradation_Homo sapiens_hsa003100.69667869
120MicroRNAs in cancer_Homo sapiens_hsa052060.69383764
121Prostate cancer_Homo sapiens_hsa052150.69316268
122Oxytocin signaling pathway_Homo sapiens_hsa049210.68894281
123Thyroid hormone synthesis_Homo sapiens_hsa049180.65009513
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63886814
125Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63536435
126Renin-angiotensin system_Homo sapiens_hsa046140.62797443
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62676822
128Axon guidance_Homo sapiens_hsa043600.62285374
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61004263
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60655413
131Base excision repair_Homo sapiens_hsa034100.60409323
132Fatty acid biosynthesis_Homo sapiens_hsa000610.60397699
133Calcium signaling pathway_Homo sapiens_hsa040200.59488887
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.58982987
135Glutathione metabolism_Homo sapiens_hsa004800.58792503
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57709826
137Glioma_Homo sapiens_hsa052140.57537291
138Biosynthesis of amino acids_Homo sapiens_hsa012300.57271991
139cAMP signaling pathway_Homo sapiens_hsa040240.56094555
140Caffeine metabolism_Homo sapiens_hsa002320.56074963
141Glucagon signaling pathway_Homo sapiens_hsa049220.55550985
142Focal adhesion_Homo sapiens_hsa045100.55498360
143Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54969078
144Drug metabolism - other enzymes_Homo sapiens_hsa009830.53326891
145ErbB signaling pathway_Homo sapiens_hsa040120.53311616
146Type II diabetes mellitus_Homo sapiens_hsa049300.51870407
147Lysosome_Homo sapiens_hsa041420.50847389
148Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49127310
149Arginine and proline metabolism_Homo sapiens_hsa003300.48910680
150Retinol metabolism_Homo sapiens_hsa008300.48543450
151Ovarian steroidogenesis_Homo sapiens_hsa049130.48495187
152Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48230819
153ABC transporters_Homo sapiens_hsa020100.48018521
154HIF-1 signaling pathway_Homo sapiens_hsa040660.47493712
155Maturity onset diabetes of the young_Homo sapiens_hsa049500.47446059
156Pancreatic secretion_Homo sapiens_hsa049720.47240103
157Gap junction_Homo sapiens_hsa045400.46289845
158Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46247296
159Glycosaminoglycan degradation_Homo sapiens_hsa005310.45903391
160Pyrimidine metabolism_Homo sapiens_hsa002400.45472920
161Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45263950
162mTOR signaling pathway_Homo sapiens_hsa041500.45145285
163ECM-receptor interaction_Homo sapiens_hsa045120.44687147
164Insulin resistance_Homo sapiens_hsa049310.43996213

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