CCDC43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.44946982
2regulation of Wnt signaling pathway involved in heart development (GO:0003307)5.00895150
3nucleobase biosynthetic process (GO:0046112)4.76599675
4purine nucleobase biosynthetic process (GO:0009113)4.73576466
5formation of translation preinitiation complex (GO:0001731)4.64646627
6negative regulation of cell fate specification (GO:0009996)4.49609437
7ribosome assembly (GO:0042255)4.48544168
8mitotic metaphase plate congression (GO:0007080)4.45559434
9maturation of SSU-rRNA (GO:0030490)4.36983670
10proteasome assembly (GO:0043248)4.28521929
11IMP biosynthetic process (GO:0006188)4.24819916
12establishment of integrated proviral latency (GO:0075713)4.16004046
13pore complex assembly (GO:0046931)4.12673434
14ribosome biogenesis (GO:0042254)4.02050560
15DNA replication initiation (GO:0006270)4.01216023
16DNA strand elongation involved in DNA replication (GO:0006271)4.00951157
17DNA deamination (GO:0045006)3.91238575
18negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.87078069
19DNA strand elongation (GO:0022616)3.83341038
20positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.82735266
21DNA unwinding involved in DNA replication (GO:0006268)3.82607276
22anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.81826361
23cullin deneddylation (GO:0010388)3.81509920
24metaphase plate congression (GO:0051310)3.81400846
25protein localization to kinetochore (GO:0034501)3.79070502
26heart field specification (GO:0003128)3.78645049
27secondary heart field specification (GO:0003139)3.78645049
28ribosomal large subunit biogenesis (GO:0042273)3.77632603
29regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.76945250
30DNA replication checkpoint (GO:0000076)3.75298785
31IMP metabolic process (GO:0046040)3.73301178
32mitotic nuclear envelope disassembly (GO:0007077)3.71064424
33DNA replication-dependent nucleosome assembly (GO:0006335)3.70251273
34DNA replication-dependent nucleosome organization (GO:0034723)3.70251273
35rRNA modification (GO:0000154)3.69858790
36ribonucleoprotein complex biogenesis (GO:0022613)3.67632643
37DNA ligation (GO:0006266)3.66460598
38ribosomal small subunit assembly (GO:0000028)3.62007730
39regulation of spindle organization (GO:0090224)3.61804878
40regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.61473732
41regulation of mitotic spindle checkpoint (GO:1903504)3.61473732
42CENP-A containing nucleosome assembly (GO:0034080)3.60932639
43chromatin remodeling at centromere (GO:0031055)3.59804218
44intra-S DNA damage checkpoint (GO:0031573)3.58933846
45telomere maintenance via semi-conservative replication (GO:0032201)3.58830261
46DNA catabolic process, exonucleolytic (GO:0000738)3.54437798
47nuclear pore organization (GO:0006999)3.53507397
48negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.51351505
49negative regulation of ligase activity (GO:0051352)3.51351505
50spliceosomal snRNP assembly (GO:0000387)3.49097309
51folic acid-containing compound biosynthetic process (GO:0009396)3.48960818
52protein deneddylation (GO:0000338)3.48190592
53cellular anion homeostasis (GO:0030002)3.47087829
54positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.45892177
55rRNA processing (GO:0006364)3.45802043
56nuclear envelope disassembly (GO:0051081)3.44770168
57membrane disassembly (GO:0030397)3.44770168
58establishment of chromosome localization (GO:0051303)3.40670223
59regulation of translation in response to stress (GO:0043555)3.39949576
60non-recombinational repair (GO:0000726)3.39943131
61double-strand break repair via nonhomologous end joining (GO:0006303)3.39943131
62kinetochore organization (GO:0051383)3.39015216
63DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.37516140
64mitotic sister chromatid segregation (GO:0000070)3.36470144
65signal transduction involved in DNA damage checkpoint (GO:0072422)3.35936504
66signal transduction involved in DNA integrity checkpoint (GO:0072401)3.35936504
67intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.34770604
68signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.34770604
69signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.34693133
70signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.34693133
71signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.34693133
72signal transduction involved in cell cycle checkpoint (GO:0072395)3.32817762
73rRNA metabolic process (GO:0016072)3.31133249
74negative regulation of cell fate commitment (GO:0010454)3.29081837
75regulation of DNA endoreduplication (GO:0032875)3.27901938
76DNA replication-independent nucleosome assembly (GO:0006336)3.27542638
77DNA replication-independent nucleosome organization (GO:0034724)3.27542638
78chaperone-mediated protein transport (GO:0072321)3.27147983
79termination of RNA polymerase I transcription (GO:0006363)3.26755067
80transcription elongation from RNA polymerase I promoter (GO:0006362)3.26687767
81telomere maintenance via recombination (GO:0000722)3.25832895
82somatic hypermutation of immunoglobulin genes (GO:0016446)3.25338934
83somatic diversification of immune receptors via somatic mutation (GO:0002566)3.25338934
84G1/S transition of mitotic cell cycle (GO:0000082)3.25251869
85cell cycle G1/S phase transition (GO:0044843)3.25251869
86translational initiation (GO:0006413)3.23533146
87spindle checkpoint (GO:0031577)3.23314169
88positive regulation of ligase activity (GO:0051351)3.23187704
89mitotic recombination (GO:0006312)3.23014693
90regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.22257276
91regulation of cellular amino acid metabolic process (GO:0006521)3.21028488
92cell migration involved in heart development (GO:0060973)3.20412173
93negative regulation of mRNA processing (GO:0050686)3.19849205
94negative regulation of chromosome segregation (GO:0051985)3.19624940
95negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.18808083
96negative regulation of sister chromatid segregation (GO:0033046)3.18808083
97negative regulation of mitotic sister chromatid separation (GO:2000816)3.18808083
98negative regulation of mitotic sister chromatid segregation (GO:0033048)3.18808083
99regulation of centriole replication (GO:0046599)3.18135158
100regulation of translational termination (GO:0006449)3.17480677
101telomere maintenance via telomere lengthening (GO:0010833)3.17195885
102establishment of protein localization to mitochondrial membrane (GO:0090151)3.16528556
103mitotic spindle checkpoint (GO:0071174)3.15982116
104mitotic spindle assembly checkpoint (GO:0007094)3.15345110
105maturation of 5.8S rRNA (GO:0000460)3.15164850
106transcription-coupled nucleotide-excision repair (GO:0006283)3.15088955
107spindle assembly checkpoint (GO:0071173)3.14265018
108transcription elongation from RNA polymerase III promoter (GO:0006385)3.13746421
109termination of RNA polymerase III transcription (GO:0006386)3.13746421
110pseudouridine synthesis (GO:0001522)3.13346899
1117-methylguanosine mRNA capping (GO:0006370)3.12974820
112protein localization to chromosome, centromeric region (GO:0071459)3.12366198
113transcription from RNA polymerase I promoter (GO:0006360)3.12113728
114regulation of mitotic spindle organization (GO:0060236)3.11501048
115positive regulation of fibroblast migration (GO:0010763)3.11095420
116DNA damage response, detection of DNA damage (GO:0042769)3.11072377
117establishment of viral latency (GO:0019043)3.10981654
118kinetochore assembly (GO:0051382)3.10495732
119regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.09654061
120regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.09199609
121regulation of mitotic metaphase/anaphase transition (GO:0030071)3.08271861
122sister chromatid segregation (GO:0000819)3.08125185
123regulation of ubiquitin-protein transferase activity (GO:0051438)3.07925108
124negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.07305558
125spliceosomal complex assembly (GO:0000245)3.06627987
126histone exchange (GO:0043486)3.06246246
127negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.01868574
128regulation of mesoderm development (GO:2000380)3.00039622
129DNA double-strand break processing (GO:0000729)2.99689754
130negative regulation of DNA-dependent DNA replication (GO:2000104)2.96066510
131cell migration involved in gastrulation (GO:0042074)2.91300624
132mitotic sister chromatid cohesion (GO:0007064)2.88797657
133negative regulation of mRNA metabolic process (GO:1903312)2.85589103
134protein targeting to mitochondrion (GO:0006626)2.82191894
135necroptotic process (GO:0070266)2.80332474
136regulation of cell fate specification (GO:0042659)2.79709797
137positive regulation of endothelial cell apoptotic process (GO:2000353)2.75688299
138negative regulation of RNA splicing (GO:0033119)2.73971380
139regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.71917411
140viral mRNA export from host cell nucleus (GO:0046784)2.71795818
141termination of RNA polymerase II transcription (GO:0006369)2.70160505
142regulation of chromosome segregation (GO:0051983)2.69073587
143isotype switching (GO:0045190)2.67803078

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.21273511
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.45072804
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.70701544
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.58603471
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.55543488
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.38607507
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.33013624
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.22679554
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.17065078
10* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.11999349
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.10773613
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.08302092
13MYC_19030024_ChIP-ChIP_MESCs_Mouse3.04190370
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90371829
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.84664637
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.72698009
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.70653963
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.64143641
19* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.59761980
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.55631934
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.43905250
22VDR_23849224_ChIP-Seq_CD4+_Human2.41499068
23XRN2_22483619_ChIP-Seq_HELA_Human2.25322072
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22463257
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.15943310
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.14869005
27DCP1A_22483619_ChIP-Seq_HELA_Human2.09443341
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.07704765
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06735301
30FOXP3_21729870_ChIP-Seq_TREG_Human2.05311033
31* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.02710326
32NANOG_18555785_ChIP-Seq_MESCs_Mouse2.02010592
33PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98263599
34MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97691576
35POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.97028227
36AR_21909140_ChIP-Seq_LNCAP_Human1.93858989
37ELK1_19687146_ChIP-ChIP_HELA_Human1.90529806
38* GABP_19822575_ChIP-Seq_HepG2_Human1.89645994
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.81930092
40* TTF2_22483619_ChIP-Seq_HELA_Human1.79816367
41* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.79429175
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.79095367
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.75157834
44ELF1_17652178_ChIP-ChIP_JURKAT_Human1.74244017
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.74001730
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.72855266
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.68655842
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66334176
49* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65337166
50SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.62968922
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.60445509
52ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56331292
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.55481726
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.50017487
55* CIITA_25753668_ChIP-Seq_RAJI_Human1.49643960
56KDM5A_27292631_Chip-Seq_BREAST_Human1.48941699
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.44089207
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.43436463
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.42008114
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.41987678
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37063899
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36940195
63EWS_26573619_Chip-Seq_HEK293_Human1.34382880
64FUS_26573619_Chip-Seq_HEK293_Human1.34069500
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.34028087
66SALL1_21062744_ChIP-ChIP_HESCs_Human1.32554745
67PCGF2_27294783_Chip-Seq_ESCs_Mouse1.31071004
68NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.30450145
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30251988
70PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.26058543
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23972175
72SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22760380
73KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.21313449
74KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.21313449
75KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.21313449
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20563629
77TFEB_21752829_ChIP-Seq_HELA_Human1.18122407
78ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.17453108
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16463903
80TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15900138
81BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14556276
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14517226
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.11904796
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11709716
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11657830
86KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.10101275
87NANOG_21062744_ChIP-ChIP_HESCs_Human1.09788959
88ELK1_22589737_ChIP-Seq_MCF10A_Human1.08043915
89VDR_22108803_ChIP-Seq_LS180_Human1.05214206
90NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.03519463
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03398572
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01804453
93E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00774698
94ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00434286
95MYC_22102868_ChIP-Seq_BL_Human0.97787213
96FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.97275730
97SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97132779
98POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96892922
99OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94663606
100SOX2_16153702_ChIP-ChIP_HESCs_Human0.93438773
101SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.93274593
102CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93045244
103CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92457379
104POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91911967
105ZNF274_21170338_ChIP-Seq_K562_Hela0.91545738
106* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90986201
107SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.90489299
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.89931942
109SOX17_20123909_ChIP-Seq_XEN_Mouse0.89041192
110CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89027947
111NOTCH1_21737748_ChIP-Seq_TLL_Human0.88938887
112SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88692566
113CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.88262395
114CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87263573
115MYC_18940864_ChIP-ChIP_HL60_Human0.87240957
116NANOG_16153702_ChIP-ChIP_HESCs_Human0.86485746
117SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.86455001
118ZNF263_19887448_ChIP-Seq_K562_Human0.84957377
119EZH2_27294783_Chip-Seq_NPCs_Mouse0.81351753
120SUZ12_27294783_Chip-Seq_NPCs_Mouse0.79256665
121NFE2_27457419_Chip-Seq_LIVER_Mouse0.79126861
122P300_19829295_ChIP-Seq_ESCs_Human0.78435722
123RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.77812732
124CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.75654329
125TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.75418707
126TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.75012586
127TAF15_26573619_Chip-Seq_HEK293_Human0.74237081

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.07432255
2MP0004957_abnormal_blastocyst_morpholog4.95403441
3MP0003111_abnormal_nucleus_morphology4.61452915
4MP0010094_abnormal_chromosome_stability4.57543609
5MP0002234_abnormal_pharynx_morphology4.36603773
6MP0003077_abnormal_cell_cycle4.10031872
7MP0008057_abnormal_DNA_replication3.66680346
8MP0003806_abnormal_nucleotide_metabolis3.55322850
9MP0008058_abnormal_DNA_repair3.32784504
10MP0000372_irregular_coat_pigmentation3.06273409
11MP0008932_abnormal_embryonic_tissue3.00985921
12MP0003123_paternal_imprinting2.91675650
13MP0008007_abnormal_cellular_replicative2.83205753
14MP0001730_embryonic_growth_arrest2.70104423
15MP0003786_premature_aging2.36363994
16MP0000350_abnormal_cell_proliferation2.33988433
17MP0010352_gastrointestinal_tract_polyps2.28231094
18MP0003136_yellow_coat_color1.97691317
19MP0001697_abnormal_embryo_size1.95208802
20MP0005380_embryogenesis_phenotype1.94852023
21MP0001672_abnormal_embryogenesis/_devel1.94852023
22MP0003718_maternal_effect1.84112255
23MP0002396_abnormal_hematopoietic_system1.82535737
24MP0008877_abnormal_DNA_methylation1.80126469
25MP0002102_abnormal_ear_morphology1.78963474
26MP0002080_prenatal_lethality1.78534157
27MP0003984_embryonic_growth_retardation1.75236202
28MP0002088_abnormal_embryonic_growth/wei1.70540463
29MP0010307_abnormal_tumor_latency1.70287191
30MP0002084_abnormal_developmental_patter1.59901918
31MP0002085_abnormal_embryonic_tissue1.59667607
32MP0002837_dystrophic_cardiac_calcinosis1.59234605
33MP0002938_white_spotting1.58839319
34MP0002086_abnormal_extraembryonic_tissu1.50021161
35MP0004197_abnormal_fetal_growth/weight/1.48805371
36MP0003567_abnormal_fetal_cardiomyocyte1.47524210
37MP0001529_abnormal_vocalization1.44291356
38MP0000490_abnormal_crypts_of1.43475628
39MP0000313_abnormal_cell_death1.41182077
40MP0003890_abnormal_embryonic-extraembry1.37325229
41MP0005408_hypopigmentation1.36455970
42MP0002177_abnormal_outer_ear1.34073696
43MP0003950_abnormal_plasma_membrane1.33287508
44MP0003121_genomic_imprinting1.33265880
45MP0002638_abnormal_pupillary_reflex1.32649959
46MP0004084_abnormal_cardiac_muscle1.31495204
47MP0006054_spinal_hemorrhage1.30070346
48MP0003186_abnormal_redox_activity1.26887785
49MP0010030_abnormal_orbit_morphology1.26253880
50MP0003315_abnormal_perineum_morphology1.25028124
51MP0001873_stomach_inflammation1.24905741
52MP0003119_abnormal_digestive_system1.23026851
53MP0010234_abnormal_vibrissa_follicle1.22158592
54MP0003221_abnormal_cardiomyocyte_apopto1.21030360
55MP0006035_abnormal_mitochondrial_morpho1.20466749
56MP0002877_abnormal_melanocyte_morpholog1.16126846
57MP0001293_anophthalmia1.15865258
58MP0002019_abnormal_tumor_incidence1.15617592
59MP0008260_abnormal_autophagy1.14365320
60MP0006036_abnormal_mitochondrial_physio1.13359743
61MP0002269_muscular_atrophy1.13289726
62MP0006072_abnormal_retinal_apoptosis1.12447979
63MP0009333_abnormal_splenocyte_physiolog1.12087717
64MP0004133_heterotaxia1.11318197
65MP0000358_abnormal_cell_content/1.10474368
66MP0001849_ear_inflammation1.08839822
67MP0000750_abnormal_muscle_regeneration1.05003016
68MP0004215_abnormal_myocardial_fiber1.02857405
69MP0000537_abnormal_urethra_morphology1.02535794
70MP0000749_muscle_degeneration0.99654196
71MP0002653_abnormal_ependyma_morphology0.98817876
72MP0005266_abnormal_metabolism0.97767738
73MP0005171_absent_coat_pigmentation0.97439436
74MP0002233_abnormal_nose_morphology0.93320965
75MP0009672_abnormal_birth_weight0.93280869
76MP0004145_abnormal_muscle_electrophysio0.92470519
77MP0002090_abnormal_vision0.91972430
78MP0003941_abnormal_skin_development0.91114702
79MP0005253_abnormal_eye_physiology0.91112800
80MP0004087_abnormal_muscle_fiber0.90439455
81MP0000747_muscle_weakness0.89967048
82MP0001145_abnormal_male_reproductive0.88785817
83MP0008789_abnormal_olfactory_epithelium0.87868823
84MP0002210_abnormal_sex_determination0.87070706
85MP0005083_abnormal_biliary_tract0.86897044
86MP0005384_cellular_phenotype0.85942857
87MP0003646_muscle_fatigue0.83632706
88MP0002095_abnormal_skin_pigmentation0.82721700
89MP0005367_renal/urinary_system_phenotyp0.80624442
90MP0000516_abnormal_urinary_system0.80624442
91MP0009053_abnormal_anal_canal0.80471899
92MP0002163_abnormal_gland_morphology0.78731284
93MP0006292_abnormal_olfactory_placode0.78385486
94MP0003763_abnormal_thymus_physiology0.78350236
95MP0001188_hyperpigmentation0.78010493
96MP0005084_abnormal_gallbladder_morpholo0.77062673
97MP0009703_decreased_birth_body0.75641349
98MP0005389_reproductive_system_phenotype0.75012304
99MP0005621_abnormal_cell_physiology0.74690444
100MP0002111_abnormal_tail_morphology0.74643012
101MP0005187_abnormal_penis_morphology0.74421347
102MP0001764_abnormal_homeostasis0.73310921
103MP0000703_abnormal_thymus_morphology0.73297166
104MP0002697_abnormal_eye_size0.72893576
105MP0002160_abnormal_reproductive_system0.72798221
106MP0000647_abnormal_sebaceous_gland0.72240077
107MP0008775_abnormal_heart_ventricle0.71398391
108MP0005075_abnormal_melanosome_morpholog0.70863886
109MP0001324_abnormal_eye_pigmentation0.70382609
110MP0003937_abnormal_limbs/digits/tail_de0.69713907
111MP0004808_abnormal_hematopoietic_stem0.69566149
112MP0001299_abnormal_eye_distance/0.69161169
113MP0000751_myopathy0.66519020
114MP0000428_abnormal_craniofacial_morphol0.66190529
115MP0000653_abnormal_sex_gland0.65969041
116MP0003787_abnormal_imprinting0.65731242
117MP0003755_abnormal_palate_morphology0.65437101
118MP0005076_abnormal_cell_differentiation0.65254226
119MP0004264_abnormal_extraembryonic_tissu0.64787991
120MP0000733_abnormal_muscle_development0.64553510
121MP0001919_abnormal_reproductive_system0.64438581
122MP0005330_cardiomyopathy0.64082029
123MP0002722_abnormal_immune_system0.63876807
124MP0001915_intracranial_hemorrhage0.63870039
125MP0002751_abnormal_autonomic_nervous0.62783102
126MP0001286_abnormal_eye_development0.61521431
127MP0004036_abnormal_muscle_relaxation0.60989800
128MP0004233_abnormal_muscle_weight0.59758465
129MP0009697_abnormal_copulation0.59379017
130MP0002127_abnormal_cardiovascular_syste0.59316729
131MP0002106_abnormal_muscle_physiology0.57455990
132MP0003566_abnormal_cell_adhesion0.57450805
133MP0000689_abnormal_spleen_morphology0.56976188
134MP0001929_abnormal_gametogenesis0.56434202
135MP0000858_altered_metastatic_potential0.53895919
136MP0000759_abnormal_skeletal_muscle0.53829126
137MP0002114_abnormal_axial_skeleton0.51492258
138MP0002398_abnormal_bone_marrow0.51206982

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.20244499
2Autoimmune thrombocytopenia (HP:0001973)4.80611769
3Decreased activity of mitochondrial respiratory chain (HP:0008972)4.65327197
4Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.65327197
5Breast hypoplasia (HP:0003187)4.20088267
6Autoimmune hemolytic anemia (HP:0001890)3.95096587
7Agnosia (HP:0010524)3.93663535
8Cerebral hypomyelination (HP:0006808)3.83785468
9Abnormality of the labia minora (HP:0012880)3.77150082
10Rough bone trabeculation (HP:0100670)3.64329247
11Colon cancer (HP:0003003)3.59317110
12Ependymoma (HP:0002888)3.57597055
13Increased IgM level (HP:0003496)3.54235974
14Oral leukoplakia (HP:0002745)3.45653565
15Carpal bone hypoplasia (HP:0001498)3.25857443
16Degeneration of anterior horn cells (HP:0002398)3.19797156
17Abnormality of the anterior horn cell (HP:0006802)3.19797156
18Patellar aplasia (HP:0006443)3.16437529
19Abnormality of cells of the erythroid lineage (HP:0012130)3.14469316
20Impulsivity (HP:0100710)3.09682288
21Myotonia (HP:0002486)3.06348204
22Aplasia/Hypoplasia of the patella (HP:0006498)3.03698928
23Reticulocytopenia (HP:0001896)2.95488599
24Lip pit (HP:0100267)2.92960702
25Chin dimple (HP:0010751)2.92185770
26Abnormal number of erythroid precursors (HP:0012131)2.90281460
27Abnormal delayed hypersensitivity skin test (HP:0002963)2.81838150
28Abnormal mitochondria in muscle tissue (HP:0008316)2.81225975
29Anterior segment dysgenesis (HP:0007700)2.80006380
30Acute encephalopathy (HP:0006846)2.74833358
31Shoulder girdle muscle weakness (HP:0003547)2.74560166
32Neoplasm of the pancreas (HP:0002894)2.73050010
33Premature graying of hair (HP:0002216)2.72170918
34Pelvic girdle muscle weakness (HP:0003749)2.71451567
35Nemaline bodies (HP:0003798)2.70296896
36Selective tooth agenesis (HP:0001592)2.68240153
37Muscle fiber inclusion bodies (HP:0100299)2.68038387
38Premature ovarian failure (HP:0008209)2.66665084
39Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.64846323
40Increased hepatocellular lipid droplets (HP:0006565)2.64507063
41Aplastic anemia (HP:0001915)2.60414115
42Absent radius (HP:0003974)2.59600536
43Medulloblastoma (HP:0002885)2.58731037
44Neonatal hypoglycemia (HP:0001998)2.57126561
45Trismus (HP:0000211)2.56039470
46Secondary amenorrhea (HP:0000869)2.54302426
47Abnormal trabecular bone morphology (HP:0100671)2.52146153
48Eosinophilia (HP:0001880)2.50746856
49Chromsome breakage (HP:0040012)2.50704911
50Progressive macrocephaly (HP:0004481)2.49757501
51Atrophy/Degeneration involving motor neurons (HP:0007373)2.49270841
52Absent thumb (HP:0009777)2.48373915
53Insulin-resistant diabetes mellitus (HP:0000831)2.47940451
54Multiple enchondromatosis (HP:0005701)2.45851270
55Depressed nasal tip (HP:0000437)2.42625754
56Cellular immunodeficiency (HP:0005374)2.41501667
57Meckel diverticulum (HP:0002245)2.41435105
58Calcaneovalgus deformity (HP:0001848)2.40266978
59Abnormality of the hip-girdle musculature (HP:0001445)2.40155934
60Abnormality of the musculature of the pelvis (HP:0001469)2.40155934
61Macrocytic anemia (HP:0001972)2.37374263
62Volvulus (HP:0002580)2.37113045
63Sparse lateral eyebrow (HP:0005338)2.36846260
64Aplasia involving forearm bones (HP:0009822)2.35909546
65Absent forearm bone (HP:0003953)2.35909546
66Hyperglycemia (HP:0003074)2.35576453
67Abnormality of the ileum (HP:0001549)2.35308212
68Abnormality of chromosome stability (HP:0003220)2.34252051
69Glucose intolerance (HP:0000833)2.32702077
70Progressive muscle weakness (HP:0003323)2.32295781
71Abnormal lung lobation (HP:0002101)2.31495848
72Chromosomal breakage induced by crosslinking agents (HP:0003221)2.30325974
73Bone marrow hypocellularity (HP:0005528)2.29889145
74Mitochondrial inheritance (HP:0001427)2.29267912
75Abnormality of the preputium (HP:0100587)2.28869359
76Stenosis of the external auditory canal (HP:0000402)2.28784530
77Lipid accumulation in hepatocytes (HP:0006561)2.26655999
78Cerebral edema (HP:0002181)2.26349913
79Respiratory failure (HP:0002878)2.26287027
80Distal arthrogryposis (HP:0005684)2.22821249
81Type 2 muscle fiber atrophy (HP:0003554)2.21894165
82Abnormality of the astrocytes (HP:0100707)2.21608497
83Astrocytoma (HP:0009592)2.21608497
84Rhabdomyosarcoma (HP:0002859)2.21035131
85Increased serum pyruvate (HP:0003542)2.20975675
86Abnormality of glycolysis (HP:0004366)2.20975675
87Pancreatic islet-cell hyperplasia (HP:0004510)2.20939942
88Deformed tarsal bones (HP:0008119)2.20417168
89Lactic acidosis (HP:0003128)2.20047449
90Aplasia/Hypoplasia of the sternum (HP:0006714)2.19732493
91Neoplasm of the colon (HP:0100273)2.19152574
92Biliary tract neoplasm (HP:0100574)2.15699181
93Abnormality of the calcaneus (HP:0008364)2.15459785
94Abnormality of the umbilical cord (HP:0010881)2.15440854
95Rimmed vacuoles (HP:0003805)2.13128832
96CNS hypomyelination (HP:0003429)2.12345182
97Hypoplastic pelvis (HP:0008839)2.11809078
98Small intestinal stenosis (HP:0012848)2.11769828
99Duodenal stenosis (HP:0100867)2.11769828
100Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.09763937
101Areflexia of lower limbs (HP:0002522)2.09573597
102Horseshoe kidney (HP:0000085)2.09149521
103Myelodysplasia (HP:0002863)2.07685961
104Personality changes (HP:0000751)2.07386276
105Nephroblastoma (Wilms tumor) (HP:0002667)2.04688120
106Postnatal microcephaly (HP:0005484)2.04365317
107Exercise-induced muscle cramps (HP:0003710)2.02868886
108Glioma (HP:0009733)2.01663444
109Aplasia/Hypoplasia of the uvula (HP:0010293)1.99962724
110Exercise intolerance (HP:0003546)1.99497391
111Increased intramyocellular lipid droplets (HP:0012240)1.99487549
112Increased serum lactate (HP:0002151)1.99007718
113Increased CSF lactate (HP:0002490)1.98158874
114Embryonal renal neoplasm (HP:0011794)1.97760058
115Glossoptosis (HP:0000162)1.96546108
116Hyperglycinemia (HP:0002154)1.95682067
117Sloping forehead (HP:0000340)1.95211210
118Microretrognathia (HP:0000308)1.94780968
119Megaloblastic anemia (HP:0001889)1.94451431
120Abnormality of methionine metabolism (HP:0010901)1.94397036
121Dysautonomia (HP:0002459)1.94015168
122Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93049857
123Abnormality of alanine metabolism (HP:0010916)1.93049857
124Hyperalaninemia (HP:0003348)1.93049857
125Neoplasm of the adrenal gland (HP:0100631)1.92452268
126Acute necrotizing encephalopathy (HP:0006965)1.90643499
127Abnormality of serum amino acid levels (HP:0003112)1.90579056
128Ulnar deviation of the wrist (HP:0003049)1.90110863
129Spastic diplegia (HP:0001264)1.90069905
130Aplasia/hypoplasia of the humerus (HP:0006507)1.89095679
131Type I transferrin isoform profile (HP:0003642)1.88845238
132Patent foramen ovale (HP:0001655)1.87797178
133Supernumerary spleens (HP:0009799)1.87751024
134Progressive external ophthalmoplegia (HP:0000590)1.87336947
135Facial cleft (HP:0002006)1.86752741
13611 pairs of ribs (HP:0000878)1.83303297
137Atresia of the external auditory canal (HP:0000413)1.82702409
138Abnormality of aspartate family amino acid metabolism (HP:0010899)1.82676504
139Unsteady gait (HP:0002317)1.82621168
140Hypoplasia of the iris (HP:0007676)1.81519668
141Premature skin wrinkling (HP:0100678)1.81354488
142Abnormality of the neuromuscular junction (HP:0003398)1.81158880
143Fatigable weakness (HP:0003473)1.81158880
144Short palpebral fissure (HP:0012745)1.80341398
145Abnormal number of incisors (HP:0011064)1.79804499
146Ovarian neoplasm (HP:0100615)1.79247788
147CNS demyelination (HP:0007305)1.78977407
148Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.78810983
149Ureteral duplication (HP:0000073)1.78748775
150Cortical dysplasia (HP:0002539)1.78518136
151Hypochromic anemia (HP:0001931)1.76781392
152Granulocytopenia (HP:0001913)1.76695718
153Abnormality of the duodenum (HP:0002246)1.76227943
154Hepatocellular necrosis (HP:0001404)1.76132441
155Bifid tongue (HP:0010297)1.75260570
156Muscle fiber atrophy (HP:0100295)1.74589188
157Methylmalonic acidemia (HP:0002912)1.73707942
158Methylmalonic aciduria (HP:0012120)1.72934852
159Reduced antithrombin III activity (HP:0001976)1.72626860
160Neck muscle weakness (HP:0000467)1.72383448
161Abnormal auditory evoked potentials (HP:0006958)1.72283379
162Lethargy (HP:0001254)1.70652546
163Muscle hypertrophy of the lower extremities (HP:0008968)1.69907515
164Abnormality of T cell physiology (HP:0011840)1.67717067
165Calf muscle hypertrophy (HP:0008981)1.66070186
166Coarctation of aorta (HP:0001680)1.63519805
167Proximal amyotrophy (HP:0007126)1.62951556
168Microglossia (HP:0000171)1.62866579
169Enlarged epiphyses (HP:0010580)1.62645347
170Abnormality of eosinophils (HP:0001879)1.62420131

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.13701176
2WEE14.38062755
3NEK13.58764161
4PIK3CA3.53288167
5TSSK63.50237853
6EIF2AK12.89774394
7CDC72.83741917
8AKT32.61905109
9EPHA22.59569627
10TRIM282.46795123
11SRPK12.46607929
12EIF2AK32.28682616
13NEK22.24339934
14STK162.21239603
15PLK42.19675976
16CDK192.12779496
17TTK2.02823704
18PNCK2.02235044
19PLK32.02184899
20PLK12.01916603
21TESK21.98869410
22BRSK21.98271162
23ACVR1B1.85293049
24VRK21.84338344
25NME21.83727254
26CCNB11.73964557
27TLK11.70116452
28OXSR11.65239683
29MKNK11.64141100
30ZAK1.56778808
31AURKB1.50037088
32BMPR1B1.44581403
33NME11.44354435
34PDK41.41521102
35PDK31.41521102
36MKNK21.41375448
37MAP3K81.41366524
38PASK1.38069266
39RPS6KB21.35785209
40CAMK1D1.33784014
41TAOK21.27178433
42ATR1.26839246
43VRK11.26381158
44DYRK31.26345069
45CHEK21.25844603
46NUAK11.18152352
47AURKA1.16455851
48CAMKK21.15510899
49CDK71.13846489
50WNK31.08440543
51BRSK11.07865338
52PAK41.06269994
53MAP2K31.06040631
54BRAF1.04061257
55TNIK1.03720899
56CHEK11.02654634
57OBSCN0.94706504
58PDK20.94309144
59CAMK1G0.92813952
60RPS6KA40.90465208
61TAF10.87163962
62BRD40.85010321
63STK30.84904924
64STK390.84867460
65STK100.83714946
66CSNK1G10.82345495
67FLT30.75055676
68LIMK10.74650079
69CDK40.73098966
70TESK10.72257131
71CSNK2A20.71952590
72ATM0.70729612
73PRKCG0.70040944
74CDK20.69575869
75CSNK1G30.68161159
76CDK120.67401852
77ERBB40.66413102
78PRKCI0.65510271
79CSNK2A10.64387748
80TGFBR10.64353298
81MOS0.62433726
82PAK10.60638148
83TGFBR20.60530757
84CSNK1G20.60171444
85CSNK1A1L0.60132844
86MELK0.59183551
87SCYL20.59093746
88MAP3K110.58774939
89MINK10.58126786
90PIM20.57363383
91ALK0.57308076
92MST40.56821756
93PTK20.54918754
94MAP3K30.54881713
95ERBB30.53753262
96NEK90.53736113
97SIK30.53454116
98EIF2AK20.51153258
99PIK3CG0.51019954
100PHKG10.50604905
101PHKG20.50604905
102MAP3K120.49045873
103CDK10.48987248
104BMPR20.48054588
105DYRK20.47761440
106STK38L0.46624397
107PIM10.46405746
108MAP3K60.46357758
109KDR0.46026216
110CSNK1E0.45714382
111BCKDK0.45607926
112PBK0.43170111
113DAPK10.42300786
114FGFR10.41870357
115MAP3K50.41330973
116ILK0.40739407
117PLK20.39922780
118TTN0.39569132
119STK240.39485166
120BCR0.39050105
121MARK30.37652323
122CDK80.37639357
123STK40.36769067
124MAP2K60.36077215
125CDK30.35651842
126GRK50.35643339
127CDK60.35591452
128LRRK20.35145965
129GRK70.34130084
130ARAF0.33875214
131MAP2K70.33463055
132CSNK1D0.31928789
133MAP3K40.31865644
134AKT20.30878859
135MAP2K40.30510999
136MET0.30053370
137MST1R0.29792011
138RPS6KA50.27850743
139YES10.25977502
140PRKDC0.22827314
141MAP3K100.22785378

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.57080829
2DNA replication_Homo sapiens_hsa030304.20501017
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.05142984
4Mismatch repair_Homo sapiens_hsa034303.86176632
5RNA polymerase_Homo sapiens_hsa030203.65163647
6RNA transport_Homo sapiens_hsa030133.38374088
7Ribosome_Homo sapiens_hsa030103.34087299
8Spliceosome_Homo sapiens_hsa030403.27701770
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.87919826
10Nucleotide excision repair_Homo sapiens_hsa034202.81031419
11Homologous recombination_Homo sapiens_hsa034402.52966103
12Base excision repair_Homo sapiens_hsa034102.52234218
13One carbon pool by folate_Homo sapiens_hsa006702.51138909
14Cell cycle_Homo sapiens_hsa041102.50155702
15Pyrimidine metabolism_Homo sapiens_hsa002402.43238887
16Propanoate metabolism_Homo sapiens_hsa006402.03257531
17Fanconi anemia pathway_Homo sapiens_hsa034601.88673785
18Basal transcription factors_Homo sapiens_hsa030221.85949306
19Caffeine metabolism_Homo sapiens_hsa002321.76110019
20RNA degradation_Homo sapiens_hsa030181.75327091
21Non-homologous end-joining_Homo sapiens_hsa034501.68190240
22mRNA surveillance pathway_Homo sapiens_hsa030151.63761211
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.55370121
24Epstein-Barr virus infection_Homo sapiens_hsa051691.47728897
25p53 signaling pathway_Homo sapiens_hsa041151.46781969
26Fatty acid elongation_Homo sapiens_hsa000621.35967214
27Purine metabolism_Homo sapiens_hsa002301.34713352
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.30687326
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.26913694
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22825709
31Vitamin B6 metabolism_Homo sapiens_hsa007501.22041851
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19751082
33Biosynthesis of amino acids_Homo sapiens_hsa012301.17678858
34Oocyte meiosis_Homo sapiens_hsa041141.12781546
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09436631
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.08653116
37Steroid biosynthesis_Homo sapiens_hsa001001.04501787
38Systemic lupus erythematosus_Homo sapiens_hsa053221.02118014
39Fructose and mannose metabolism_Homo sapiens_hsa000510.98020488
40Huntingtons disease_Homo sapiens_hsa050160.97781883
41Folate biosynthesis_Homo sapiens_hsa007900.97377699
42Parkinsons disease_Homo sapiens_hsa050120.96602073
43Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95345917
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94787207
45Oxidative phosphorylation_Homo sapiens_hsa001900.93243480
46Carbon metabolism_Homo sapiens_hsa012000.90989899
47Viral carcinogenesis_Homo sapiens_hsa052030.90845172
48Antigen processing and presentation_Homo sapiens_hsa046120.88439445
49Pentose phosphate pathway_Homo sapiens_hsa000300.88358733
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87271422
51Regulation of autophagy_Homo sapiens_hsa041400.85567849
52African trypanosomiasis_Homo sapiens_hsa051430.85289208
53Selenocompound metabolism_Homo sapiens_hsa004500.82014801
54Protein export_Homo sapiens_hsa030600.78352889
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.70441413
56Thyroid cancer_Homo sapiens_hsa052160.66423442
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65500284
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63372456
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62105411
60Legionellosis_Homo sapiens_hsa051340.56402758
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55600821
62HTLV-I infection_Homo sapiens_hsa051660.55149349
63Fatty acid metabolism_Homo sapiens_hsa012120.54675984
64Sulfur metabolism_Homo sapiens_hsa009200.54202384
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51784839
66Glutathione metabolism_Homo sapiens_hsa004800.49762440
67Galactose metabolism_Homo sapiens_hsa000520.49481394
68Herpes simplex infection_Homo sapiens_hsa051680.49428194
69Nitrogen metabolism_Homo sapiens_hsa009100.46821485
70Sulfur relay system_Homo sapiens_hsa041220.46774855
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.42034052
72Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41531082
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.41037116
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38721420
75HIF-1 signaling pathway_Homo sapiens_hsa040660.38497030
76Hippo signaling pathway_Homo sapiens_hsa043900.36976212
77Fatty acid degradation_Homo sapiens_hsa000710.36281531
78mTOR signaling pathway_Homo sapiens_hsa041500.36096306
79Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33381773
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33129538
81beta-Alanine metabolism_Homo sapiens_hsa004100.32644793
82Arginine biosynthesis_Homo sapiens_hsa002200.32478977
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.32228748
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32049905
85Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31945328
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31737880
87Alzheimers disease_Homo sapiens_hsa050100.31400120
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30116171
89Metabolic pathways_Homo sapiens_hsa011000.29192722
90MicroRNAs in cancer_Homo sapiens_hsa052060.28478221
91Tight junction_Homo sapiens_hsa045300.28461191
92Tryptophan metabolism_Homo sapiens_hsa003800.27732276
93Alcoholism_Homo sapiens_hsa050340.27711381
94Apoptosis_Homo sapiens_hsa042100.27510933
95Peroxisome_Homo sapiens_hsa041460.25311862
96Colorectal cancer_Homo sapiens_hsa052100.23020990
97Butanoate metabolism_Homo sapiens_hsa006500.21522865
98Shigellosis_Homo sapiens_hsa051310.19941060
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.18699212
100Small cell lung cancer_Homo sapiens_hsa052220.18103216
101TGF-beta signaling pathway_Homo sapiens_hsa043500.17485843
102Pyruvate metabolism_Homo sapiens_hsa006200.16670660
103Renin-angiotensin system_Homo sapiens_hsa046140.15638627
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.14432191
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.14255175
106Circadian rhythm_Homo sapiens_hsa047100.13722246
107Adherens junction_Homo sapiens_hsa045200.13469237
108Bladder cancer_Homo sapiens_hsa052190.13078473
109N-Glycan biosynthesis_Homo sapiens_hsa005100.12238225
110Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.12230700
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.11700928
112Basal cell carcinoma_Homo sapiens_hsa052170.11527590
113FoxO signaling pathway_Homo sapiens_hsa040680.11147799
114SNARE interactions in vesicular transport_Homo sapiens_hsa041300.08653565
115Arginine and proline metabolism_Homo sapiens_hsa003300.08653374
116Wnt signaling pathway_Homo sapiens_hsa043100.08502209
117Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.08348945
118Phototransduction_Homo sapiens_hsa047440.08202263
119Cardiac muscle contraction_Homo sapiens_hsa042600.07521452
120Vibrio cholerae infection_Homo sapiens_hsa051100.07408572
121Melanoma_Homo sapiens_hsa052180.06892083
122Hepatitis B_Homo sapiens_hsa051610.06508499
123Fat digestion and absorption_Homo sapiens_hsa049750.06099743
124Hedgehog signaling pathway_Homo sapiens_hsa043400.04223938
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.04188699
126Prostate cancer_Homo sapiens_hsa052150.03778193
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.03538324
128Pathways in cancer_Homo sapiens_hsa052000.02121479

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