CCDC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular filtration (GO:0003094)5.41665048
2renal filtration (GO:0097205)5.03154500
3cell migration involved in heart development (GO:0060973)4.96118293
4hemidesmosome assembly (GO:0031581)4.95353547
5positive regulation of phosphoprotein phosphatase activity (GO:0032516)4.74945046
6mesenchymal cell development (GO:0014031)4.53740085
7lung epithelium development (GO:0060428)4.52179739
8atrioventricular valve morphogenesis (GO:0003181)4.48632174
9glomerular basement membrane development (GO:0032836)4.46498643
10lateral sprouting from an epithelium (GO:0060601)4.42245626
11axon extension involved in axon guidance (GO:0048846)4.13800053
12neuron projection extension involved in neuron projection guidance (GO:1902284)4.13800053
13cilium movement (GO:0003341)3.98094960
14potassium ion import (GO:0010107)3.96915447
15limb bud formation (GO:0060174)3.90058384
16Notch signaling involved in heart development (GO:0061314)3.89497808
17branching involved in salivary gland morphogenesis (GO:0060445)3.77822088
18relaxation of smooth muscle (GO:0044557)3.76756287
19positive regulation of fatty acid beta-oxidation (GO:0032000)3.76192451
20positive regulation of fatty acid oxidation (GO:0046321)3.73651289
21kidney mesenchyme development (GO:0072074)3.69485244
22regulation of sequestering of triglyceride (GO:0010889)3.68569313
23brown fat cell differentiation (GO:0050873)3.68310924
24dermatan sulfate biosynthetic process (GO:0030208)3.67771622
25stem cell development (GO:0048864)3.64376411
26negative regulation of homotypic cell-cell adhesion (GO:0034111)3.61799659
27lymph vessel development (GO:0001945)3.55979405
28regulation of glucose import in response to insulin stimulus (GO:2001273)3.54577147
29planar cell polarity pathway involved in neural tube closure (GO:0090179)3.53849016
30sodium ion export (GO:0071436)3.53354926
31keratan sulfate catabolic process (GO:0042340)3.52174467
32cGMP-mediated signaling (GO:0019934)3.50810231
33neural crest cell development (GO:0014032)3.46632814
34positive regulation of glomerulus development (GO:0090193)3.45121937
35gamma-aminobutyric acid transport (GO:0015812)3.39611041
36dermatan sulfate metabolic process (GO:0030205)3.37699415
37negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.36861930
38glomerular epithelial cell development (GO:0072310)3.33225211
39lung lobe morphogenesis (GO:0060463)3.29882986
40G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.29256028
41metanephric mesenchyme development (GO:0072075)3.25841839
42regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.24955739
43desmosome organization (GO:0002934)3.23119736
44ventricular system development (GO:0021591)3.23023996
45white fat cell differentiation (GO:0050872)3.19245926
46glomerulus development (GO:0032835)3.18473527
47synaptic vesicle docking involved in exocytosis (GO:0016081)3.17420334
48peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.17241488
49epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.15916821
50response to gravity (GO:0009629)3.15861660
51aorta morphogenesis (GO:0035909)3.14169664
52retina vasculature morphogenesis in camera-type eye (GO:0061299)3.14156913
53endocardial cushion morphogenesis (GO:0003203)3.13180193
54regulation of fatty acid oxidation (GO:0046320)3.12570194
55basement membrane organization (GO:0071711)3.11176092
56negative regulation of cartilage development (GO:0061037)3.10671281
57establishment of planar polarity (GO:0001736)3.08963368
58establishment of tissue polarity (GO:0007164)3.08963368
59one-carbon compound transport (GO:0019755)3.08852748
60lung-associated mesenchyme development (GO:0060484)3.08773005
61negative regulation of leukocyte chemotaxis (GO:0002689)3.05079853
62ventricular septum morphogenesis (GO:0060412)3.04148197
63astrocyte differentiation (GO:0048708)3.00970165
64positive regulation of odontogenesis (GO:0042482)2.99848531
65heart valve formation (GO:0003188)2.99631292
66protein heterotrimerization (GO:0070208)2.98395451
67nephron epithelium development (GO:0072009)2.97543110
68cell proliferation involved in metanephros development (GO:0072203)2.95248889
69regulation of mesenchymal cell apoptotic process (GO:2001053)2.93819584
70non-canonical Wnt signaling pathway (GO:0035567)2.90369790
71endothelium development (GO:0003158)2.89943949
72cellular potassium ion homeostasis (GO:0030007)2.89682339
73negative regulation of axon guidance (GO:1902668)2.89265228
74nephron tubule development (GO:0072080)2.88380009
75response to parathyroid hormone (GO:0071107)2.84667839
76cell proliferation involved in kidney development (GO:0072111)2.82973612
77positive regulation of gastrulation (GO:2000543)2.81231404
78carnitine shuttle (GO:0006853)2.80162973
79response to dietary excess (GO:0002021)2.78925331
80mesenchyme morphogenesis (GO:0072132)2.78826095
81positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.77116552
82biotin metabolic process (GO:0006768)2.76402845
83regulation of glomerulus development (GO:0090192)2.75984731
84negative regulation of catenin import into nucleus (GO:0035414)2.75813256
85negative regulation of chondrocyte differentiation (GO:0032331)2.74904519
86fatty acid transmembrane transport (GO:1902001)2.73898762
87membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.73390657
88regulation of fatty acid beta-oxidation (GO:0031998)2.72581568
89enteric nervous system development (GO:0048484)2.72325892
90tonic smooth muscle contraction (GO:0014820)2.72278878
91cGMP biosynthetic process (GO:0006182)2.68922770
92muscle cell proliferation (GO:0033002)2.66114082
93cardiac epithelial to mesenchymal transition (GO:0060317)2.62913526
94positive regulation of cellular response to insulin stimulus (GO:1900078)2.61545282
95negative regulation of axon extension involved in axon guidance (GO:0048843)2.61423619
96low-density lipoprotein particle clearance (GO:0034383)2.61010172
97left/right axis specification (GO:0070986)2.60884940
98negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.60509706
99establishment of nucleus localization (GO:0040023)2.60404610
100mesenchymal cell proliferation (GO:0010463)2.60116913
101negative regulation of vascular permeability (GO:0043116)2.58917141
102cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.57993676
103positive regulation of embryonic development (GO:0040019)2.57145968
104coronary vasculature morphogenesis (GO:0060977)2.56050920
105regulation of phospholipase A2 activity (GO:0032429)2.55682518
106epithelial cilium movement (GO:0003351)2.54504585
107cGMP metabolic process (GO:0046068)2.53891209
108cell-substrate junction assembly (GO:0007044)2.52961816
109hair follicle development (GO:0001942)2.52812142
110glutamate secretion (GO:0014047)2.52419269
111cell migration involved in sprouting angiogenesis (GO:0002042)2.52334506
112negative regulation of humoral immune response (GO:0002921)2.52117352
113cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.51709906
114extracellular fibril organization (GO:0043206)2.51493083
115vascular endothelial growth factor signaling pathway (GO:0038084)2.51434931
116embryonic skeletal system development (GO:0048706)2.51181113
117renal tubule development (GO:0061326)2.50490558
118peripheral nervous system axon ensheathment (GO:0032292)2.50313157
119myelination in peripheral nervous system (GO:0022011)2.50313157
120heart valve morphogenesis (GO:0003179)2.49840104
121artery smooth muscle contraction (GO:0014824)2.48945835
122chondrocyte development (GO:0002063)2.48871228
123smooth muscle tissue development (GO:0048745)2.48279636
124barbed-end actin filament capping (GO:0051016)2.47849923
125establishment of apical/basal cell polarity (GO:0035089)2.47424715
126negative regulation of protein autophosphorylation (GO:0031953)2.47355189
127negative chemotaxis (GO:0050919)2.46836788
128triglyceride catabolic process (GO:0019433)2.46097277
129collagen fibril organization (GO:0030199)2.45776787
130cardiac muscle cell proliferation (GO:0060038)2.45580012
131cardiac ventricle morphogenesis (GO:0003208)2.44358359
132establishment of skin barrier (GO:0061436)2.44158042
133regulation of axon guidance (GO:1902667)2.44009243
134regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.43806592
135fatty acid beta-oxidation (GO:0006635)2.43268986
136positive regulation of catenin import into nucleus (GO:0035413)2.42812824
137axonemal dynein complex assembly (GO:0070286)2.42648318
138convergent extension (GO:0060026)2.42551718
139keratinization (GO:0031424)2.42482692
140regulation of cAMP-dependent protein kinase activity (GO:2000479)2.42383983
141cardiac right ventricle morphogenesis (GO:0003215)2.42040286
142negative regulation of muscle contraction (GO:0045932)2.41867297
143cell communication by electrical coupling (GO:0010644)2.41168329
144carnitine transmembrane transport (GO:1902603)2.40532649
145positive regulation of smoothened signaling pathway (GO:0045880)2.39671043
146chondrocyte proliferation (GO:0035988)2.38935561
147cell volume homeostasis (GO:0006884)2.38368754
148heart trabecula formation (GO:0060347)2.37095174
149organ formation (GO:0048645)2.36975994
150negative regulation of Rho protein signal transduction (GO:0035024)2.36852353
151artery morphogenesis (GO:0048844)2.36582774
152vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.36209340
153positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.35555101
154activation of protein kinase A activity (GO:0034199)2.35210010
155striated muscle cell proliferation (GO:0014855)2.34985151
156Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.34711517
157relaxation of muscle (GO:0090075)2.34619266
158cardiac myofibril assembly (GO:0055003)2.34572967
159cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.33467430
160notochord development (GO:0030903)2.33450941
161adherens junction assembly (GO:0034333)2.33088131
162patterning of blood vessels (GO:0001569)2.32985350
163chondroitin sulfate catabolic process (GO:0030207)2.32750543
164regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.32692874
165innervation (GO:0060384)2.31962635
166cochlea morphogenesis (GO:0090103)2.31483851
167angiogenesis involved in wound healing (GO:0060055)2.31272918
168retinal ganglion cell axon guidance (GO:0031290)2.30980450
169cell surface receptor signaling pathway involved in heart development (GO:0061311)2.30544993
170proline transport (GO:0015824)2.29748096
171somite development (GO:0061053)2.29719039
172cardiac chamber morphogenesis (GO:0003206)2.29695474
173regulation of transforming growth factor beta2 production (GO:0032909)2.29675274
174response to leptin (GO:0044321)2.29514532
175positive regulation of BMP signaling pathway (GO:0030513)2.29408470

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.21849586
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.01680643
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.78115082
4EZH2_22144423_ChIP-Seq_EOC_Human2.49352877
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.40600567
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.31039617
7SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23701544
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22058024
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22058024
10TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.16300258
11* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.14510252
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.14384727
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.11775343
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.05561294
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.02311597
16CLOCK_20551151_ChIP-Seq_293T_Human1.96630199
17AR_21572438_ChIP-Seq_LNCaP_Human1.93347589
18JARID2_20075857_ChIP-Seq_MESCs_Mouse1.92678389
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.89907869
20* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.89723035
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.85376762
22* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.85197953
23PIAS1_25552417_ChIP-Seq_VCAP_Human1.83482718
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.80444985
25CDX2_19796622_ChIP-Seq_MESCs_Mouse1.73899987
26RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.71445489
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.68610642
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.68296781
29* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.66952788
30PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.66167671
31CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.65412232
32ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65141611
33CJUN_26792858_Chip-Seq_BT549_Human1.59614145
34TP53_20018659_ChIP-ChIP_R1E_Mouse1.58613852
35RXR_22108803_ChIP-Seq_LS180_Human1.56473260
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.56216856
37GBX2_23144817_ChIP-Seq_PC3_Human1.54064982
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.53932112
39EP300_21415370_ChIP-Seq_HL-1_Mouse1.50889043
40* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.44743574
41PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42570931
42TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40888959
43AHR_22903824_ChIP-Seq_MCF-7_Human1.40591750
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.37764194
45NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37275127
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.36848552
47BCAT_22108803_ChIP-Seq_LS180_Human1.36546149
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.30509299
49ERG_21242973_ChIP-ChIP_JURKAT_Human1.29034649
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.28732652
51STAT6_21828071_ChIP-Seq_BEAS2B_Human1.25309571
52KDM2B_26808549_Chip-Seq_K562_Human1.24785473
53CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23802847
54RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22579146
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22551476
56RING1B_27294783_Chip-Seq_ESCs_Mouse1.22264804
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.21991115
58ESR1_21235772_ChIP-Seq_MCF-7_Human1.21383100
59CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.21204541
60WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19963657
61TP53_18474530_ChIP-ChIP_U2OS_Human1.19061265
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.18148335
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.17065334
64NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.16754086
65NRF2_20460467_ChIP-Seq_MEFs_Mouse1.16754086
66ESR1_20079471_ChIP-ChIP_T-47D_Human1.15467989
67* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.14863470
68RING1B_27294783_Chip-Seq_NPCs_Mouse1.14427441
69ZNF263_19887448_ChIP-Seq_K562_Human1.13179440
70DROSHA_22980978_ChIP-Seq_HELA_Human1.12632585
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12501063
72TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.11756004
73SMC1_22415368_ChIP-Seq_MEFs_Mouse1.11741647
74* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.10367891
75TBX20_22080862_ChIP-Seq_HEART_Mouse1.10329025
76TBX20_22328084_ChIP-Seq_HEART_Mouse1.10329025
77TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.09405083
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09137700
79ISL1_27105846_Chip-Seq_CPCs_Mouse1.08722872
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08606737
81SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.07572102
82P300_19829295_ChIP-Seq_ESCs_Human1.07106876
83* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07049218
84SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06646917
85WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06624907
86SMAD3_21741376_ChIP-Seq_HESCs_Human1.06390091
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04809380
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03171367
89WT1_19549856_ChIP-ChIP_CCG9911_Human1.03038668
90* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03012308
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01442897
92SA1_22415368_ChIP-Seq_MEFs_Mouse1.00748384
93SMAD4_21799915_ChIP-Seq_A2780_Human1.00377157
94* RNF2_27304074_Chip-Seq_NSC_Mouse0.98882402
95SMAD3_21741376_ChIP-Seq_EPCs_Human0.98065602
96NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97686373
97TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97673057
98* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97396432
99FOXM1_26456572_ChIP-Seq_MCF-7_Human0.96447316
100SMC3_22415368_ChIP-Seq_MEFs_Mouse0.96407345
101TCF4_18268006_ChIP-ChIP_LS174T_Human0.96298532
102PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96147128
103GATA2_21666600_ChIP-Seq_HMVEC_Human0.95968517
104TET1_21490601_ChIP-Seq_MESCs_Mouse0.95956454
105KLF5_25053715_ChIP-Seq_YYC3_Human0.95777823
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95437921
107DNAJC2_21179169_ChIP-ChIP_NT2_Human0.95411005
108AR_25329375_ChIP-Seq_VCAP_Human0.95356882
109MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.95282982
110TP53_16413492_ChIP-PET_HCT116_Human0.95254402
111ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95207506
112CTCF_27219007_Chip-Seq_Bcells_Human0.94880779
113FOXO3_23340844_ChIP-Seq_DLD1_Human0.92895754
114TOP2B_26459242_ChIP-Seq_MCF-7_Human0.92076592
115CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91707664
116OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91602032
117CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.91346282
118NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89533530
119NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88668531
120RARB_27405468_Chip-Seq_BRAIN_Mouse0.88646866
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88303261
122* SMAD4_21741376_ChIP-Seq_HESCs_Human0.86965175
123LXR_22292898_ChIP-Seq_THP-1_Human0.85625377
124ZFP281_27345836_Chip-Seq_ESCs_Mouse0.85211104
125MYC_27129775_Chip-Seq_CORNEA_Mouse0.85176069
126REST_21632747_ChIP-Seq_MESCs_Mouse0.84366465
127ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.82735428
128HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82597827
129YAP1_20516196_ChIP-Seq_MESCs_Mouse0.82216685
130NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.79273724
131UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.78879389
132CDX2_20551321_ChIP-Seq_CACO-2_Human0.78871319
133* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.77706260
134SOX2_20726797_ChIP-Seq_SW620_Human0.77329386
135CTNNB1_20460455_ChIP-Seq_HCT116_Human0.76891561
136SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75463194
137RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74987620
138* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.74488591
139TP53_23651856_ChIP-Seq_MEFs_Mouse0.74329933

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose3.59024449
2MP0005275_abnormal_skin_tensile3.12910622
3MP0008438_abnormal_cutaneous_collagen3.08014827
4MP0002254_reproductive_system_inflammat2.96386498
5MP0004272_abnormal_basement_membrane2.95760419
6MP0003283_abnormal_digestive_organ2.55770911
7MP0005666_abnormal_adipose_tissue2.52382943
8MP0002249_abnormal_larynx_morphology2.48515819
9MP0004185_abnormal_adipocyte_glucose2.38899898
10MP0000467_abnormal_esophagus_morphology2.38575297
11MP0004859_abnormal_synaptic_plasticity2.28326872
12MP0000537_abnormal_urethra_morphology2.24200306
13MP0009053_abnormal_anal_canal2.16469019
14MP0005503_abnormal_tendon_morphology2.13234119
15MP0002282_abnormal_trachea_morphology2.09535852
16MP0004130_abnormal_muscle_cell2.09156688
17MP0010368_abnormal_lymphatic_system2.07653683
18MP0010030_abnormal_orbit_morphology2.04484099
19MP0009384_cardiac_valve_regurgitation2.00851179
20MP0003705_abnormal_hypodermis_morpholog1.91495186
21MP0005623_abnormal_meninges_morphology1.90100390
22MP0000566_synostosis1.87980772
23MP0002060_abnormal_skin_morphology1.85468934
24MP0000013_abnormal_adipose_tissue1.83731805
25MP0000767_abnormal_smooth_muscle1.83331440
26MP0009250_abnormal_appendicular_skeleto1.81731394
27MP0000383_abnormal_hair_follicle1.80934694
28MP0005375_adipose_tissue_phenotype1.80392077
29MP0002009_preneoplasia1.79736275
30MP0005423_abnormal_somatic_nervous1.78823583
31MP0000762_abnormal_tongue_morphology1.78223815
32MP0002234_abnormal_pharynx_morphology1.77603367
33MP0003941_abnormal_skin_development1.76565310
34MP0002796_impaired_skin_barrier1.74084602
35MP0001346_abnormal_lacrimal_gland1.73910801
36MP0009780_abnormal_chondrocyte_physiolo1.72803900
37MP0005595_abnormal_vascular_smooth1.63947562
38MP0004270_analgesia1.62262963
39MP0005257_abnormal_intraocular_pressure1.58790930
40MP0002837_dystrophic_cardiac_calcinosis1.58399366
41MP0008004_abnormal_stomach_pH1.57703588
42MP0002971_abnormal_brown_adipose1.55139059
43MP0001299_abnormal_eye_distance/1.50701568
44MP0000049_abnormal_middle_ear1.45955122
45MP0005508_abnormal_skeleton_morphology1.45380636
46MP0002102_abnormal_ear_morphology1.42299900
47MP0010678_abnormal_skin_adnexa1.40650704
48MP0000003_abnormal_adipose_tissue1.39735450
49MP0003942_abnormal_urinary_system1.37275910
50MP0003938_abnormal_ear_development1.36435097
51MP0001879_abnormal_lymphatic_vessel1.35763366
52MP0003279_aneurysm1.34493369
53MP0002108_abnormal_muscle_morphology1.32955340
54MP0002233_abnormal_nose_morphology1.31627588
55MP0003566_abnormal_cell_adhesion1.24731376
56MP0003635_abnormal_synaptic_transmissio1.24051509
57MP0010234_abnormal_vibrissa_follicle1.23149162
58MP0003011_delayed_dark_adaptation1.23122511
59MP0005646_abnormal_pituitary_gland1.20180811
60MP0001542_abnormal_bone_strength1.19739504
61MP0000163_abnormal_cartilage_morphology1.19473416
62MP0003646_muscle_fatigue1.18823157
63MP0002896_abnormal_bone_mineralization1.17594975
64MP0000462_abnormal_digestive_system1.15757444
65MP0002933_joint_inflammation1.14774585
66MP0000647_abnormal_sebaceous_gland1.14401654
67MP0009115_abnormal_fat_cell1.13739236
68MP0000579_abnormal_nail_morphology1.13643665
69MP0003136_yellow_coat_color1.12200498
70MP0000428_abnormal_craniofacial_morphol1.10492111
71MP0004215_abnormal_myocardial_fiber1.10123772
72MP0004858_abnormal_nervous_system1.09841041
73MP0003091_abnormal_cell_migration1.07312005
74MP0002295_abnormal_pulmonary_circulatio1.06403787
75MP0003880_abnormal_central_pattern1.06060396
76MP0004133_heterotaxia1.04740139
77MP0001340_abnormal_eyelid_morphology1.04300540
78MP0003937_abnormal_limbs/digits/tail_de1.03945986
79MP0005164_abnormal_response_to1.03799412
80MP0002098_abnormal_vibrissa_morphology1.03681358
81MP0001958_emphysema1.03585908
82MP0003755_abnormal_palate_morphology1.03181928
83MP0003385_abnormal_body_wall1.02242575
84MP0010771_integument_phenotype1.01761462
85MP0000534_abnormal_ureter_morphology1.00692912
86MP0002116_abnormal_craniofacial_bone1.00400642
87MP0004084_abnormal_cardiac_muscle0.99545642
88MP0005409_darkened_coat_color0.98157189
89MP0002734_abnormal_mechanical_nocicepti0.97680571
90MP0005187_abnormal_penis_morphology0.96527448
91MP0003453_abnormal_keratinocyte_physiol0.94556429
92MP0001501_abnormal_sleep_pattern0.94131621
93MP0002932_abnormal_joint_morphology0.93023956
94MP0002972_abnormal_cardiac_muscle0.91137806
95MP0008569_lethality_at_weaning0.90109246
96MP0002063_abnormal_learning/memory/cond0.89262204
97MP0002111_abnormal_tail_morphology0.88475302
98MP0002128_abnormal_blood_circulation0.86763502
99MP0002638_abnormal_pupillary_reflex0.86209626
100MP0002127_abnormal_cardiovascular_syste0.85985788
101MP0001614_abnormal_blood_vessel0.85167058
102MP0000230_abnormal_systemic_arterial0.85158883
103MP0003690_abnormal_glial_cell0.85005096
104MP0006138_congestive_heart_failure0.84830686
105MP0001216_abnormal_epidermal_layer0.83527164
106MP0003959_abnormal_lean_body0.83430355
107MP0002115_abnormal_skeleton_extremities0.82914972
108MP0010329_abnormal_lipoprotein_level0.82657583
109MP0009745_abnormal_behavioral_response0.81681981
110MP0005620_abnormal_muscle_contractility0.81038347
111MP0000343_altered_response_to0.80994823
112MP0005023_abnormal_wound_healing0.80899657
113MP0005165_increased_susceptibility_to0.80515625
114MP0005390_skeleton_phenotype0.79977694
115MP0000778_abnormal_nervous_system0.79780921
116MP0003075_altered_response_to0.79170614
117MP0001270_distended_abdomen0.78871924
118MP0005385_cardiovascular_system_phenoty0.78817074
119MP0001544_abnormal_cardiovascular_syste0.78817074
120MP0004087_abnormal_muscle_fiber0.78277689
121MP0009379_abnormal_foot_pigmentation0.77364531
122MP0002572_abnormal_emotion/affect_behav0.77016412
123MP0003879_abnormal_hair_cell0.75986057
124MP0000432_abnormal_head_morphology0.75804260
125MP0000751_myopathy0.75614116
126MP0002272_abnormal_nervous_system0.74399298
127MP0002109_abnormal_limb_morphology0.73695703
128MP0005535_abnormal_body_temperature0.73609457
129MP0001851_eye_inflammation0.73545456
130MP0000733_abnormal_muscle_development0.73352543
131MP0000613_abnormal_salivary_gland0.72791465
132MP0002064_seizures0.72607729
133MP0010630_abnormal_cardiac_muscle0.72134800
134MP0003828_pulmonary_edema0.71354713
135MP0004885_abnormal_endolymph0.71327736
136MP0000759_abnormal_skeletal_muscle0.71160567
137MP0004145_abnormal_muscle_electrophysio0.70730528
138MP0004233_abnormal_muscle_weight0.70272272
139MP0000249_abnormal_blood_vessel0.68750571
140MP0001664_abnormal_digestion0.67937707
141MP0001177_atelectasis0.67717401
142MP0002133_abnormal_respiratory_system0.67716610
143MP0005388_respiratory_system_phenotype0.67716610
144MP0008961_abnormal_basal_metabolism0.67700353
145MP0000026_abnormal_inner_ear0.67455115
146MP0000427_abnormal_hair_cycle0.66804137
147MP0002909_abnormal_adrenal_gland0.66535686
148MP0001486_abnormal_startle_reflex0.66491471
149MP0004036_abnormal_muscle_relaxation0.66478793
150MP0003935_abnormal_craniofacial_develop0.65995231

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.17011010
2Abnormal respiratory motile cilium physiology (HP:0012261)4.29994663
3Aortic aneurysm (HP:0004942)4.00314990
4Axonal loss (HP:0003447)3.81592048
5Cerebral aneurysm (HP:0004944)3.76398780
6Acanthosis nigricans (HP:0000956)3.56654673
7Papilledema (HP:0001085)3.55832375
8Protrusio acetabuli (HP:0003179)3.51696384
9Bronchomalacia (HP:0002780)3.46230976
10Rhinitis (HP:0012384)3.41406099
11Atrophic scars (HP:0001075)3.38732916
12Shallow orbits (HP:0000586)3.37867184
13Broad metatarsal (HP:0001783)3.35604729
14Increased connective tissue (HP:0009025)3.29392911
15Premature rupture of membranes (HP:0001788)3.22777708
16Metaphyseal dysplasia (HP:0100255)3.20503684
17Abnormal ciliary motility (HP:0012262)3.12877648
18Chronic bronchitis (HP:0004469)3.10233475
19Humeroradial synostosis (HP:0003041)3.09653008
20Synostosis involving the elbow (HP:0003938)3.09653008
21Aplasia involving bones of the upper limbs (HP:0009823)3.07274595
22Aplasia of the phalanges of the hand (HP:0009802)3.07274595
23Aplasia involving bones of the extremities (HP:0009825)3.07274595
24Fragile nails (HP:0001808)3.07245244
25Fragile skin (HP:0001030)3.02428354
26Short hallux (HP:0010109)2.99135162
27Vascular tortuosity (HP:0004948)2.95044900
28Abnormality of dentin (HP:0010299)2.94948728
29Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.93232495
30Arterial tortuosity (HP:0005116)2.92732480
31Hypercortisolism (HP:0001578)2.89130502
32Milia (HP:0001056)2.88004265
33Bladder diverticulum (HP:0000015)2.83546579
34Spinal rigidity (HP:0003306)2.75239937
35Ankle contracture (HP:0006466)2.74710957
36Concave nail (HP:0001598)2.71150772
37Pulmonary artery stenosis (HP:0004415)2.69720894
38Abnormality of the middle phalanges of the toes (HP:0010183)2.69196286
39Hemiplegia (HP:0002301)2.68549385
40Vertebral arch anomaly (HP:0008438)2.66513389
41Tarsal synostosis (HP:0008368)2.64735267
42Abnormality of the vertebral endplates (HP:0005106)2.64269425
43Neonatal short-limb short stature (HP:0008921)2.63976418
44Hypercalcemia (HP:0003072)2.62959909
45Aplasia/Hypoplasia of the hallux (HP:0008362)2.62381767
46Ectopia lentis (HP:0001083)2.59962304
47Ridged nail (HP:0001807)2.56988398
48Abnormality of calcium-phosphate metabolism (HP:0100530)2.56203283
49Follicular hyperkeratosis (HP:0007502)2.55177342
50Maternal diabetes (HP:0009800)2.53196287
51Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.48384800
52Wormian bones (HP:0002645)2.45301304
53Synostosis involving bones of the feet (HP:0009140)2.44620959
54Synostosis involving bones of the lower limbs (HP:0009138)2.44620959
55Right ventricular cardiomyopathy (HP:0011663)2.41811223
56Back pain (HP:0003418)2.38014956
57Difficulty running (HP:0009046)2.37677988
58Onycholysis (HP:0001806)2.35370893
59Venous insufficiency (HP:0005293)2.29144286
60Ulnar claw (HP:0001178)2.28415254
61Mitral valve prolapse (HP:0001634)2.28414135
62Infantile muscular hypotonia (HP:0008947)2.28096913
63Cranial hyperostosis (HP:0004437)2.27210132
64Turricephaly (HP:0000262)2.25450566
65Genu recurvatum (HP:0002816)2.23937871
66Sudden death (HP:0001699)2.23821901
67Mild short stature (HP:0003502)2.23420151
68Craniofacial hyperostosis (HP:0004493)2.23216319
69Mesangial abnormality (HP:0001966)2.23161551
70Increased variability in muscle fiber diameter (HP:0003557)2.23023884
71Morphological abnormality of the middle ear (HP:0008609)2.22999025
72Type 1 muscle fiber predominance (HP:0003803)2.21999115
73Hyperglycinuria (HP:0003108)2.20158799
74Hyperthyroidism (HP:0000836)2.19485370
75Abnormality of the ischium (HP:0003174)2.19363110
76Fibular hypoplasia (HP:0003038)2.16707247
77Tubular atrophy (HP:0000092)2.15811824
78Absent/shortened dynein arms (HP:0200106)2.13788418
79Dynein arm defect of respiratory motile cilia (HP:0012255)2.13788418
80Aplasia cutis congenita (HP:0001057)2.12223886
81Myokymia (HP:0002411)2.11023395
82Broad distal phalanx of finger (HP:0009836)2.10618559
83Anterior segment dysgenesis (HP:0007700)2.10120167
84Broad ribs (HP:0000885)2.09999404
85Spinal cord compression (HP:0002176)2.08192745
86Abnormality of the frontal sinuses (HP:0002687)2.07016129
87Anophthalmia (HP:0000528)2.06458659
88Prenatal maternal abnormality (HP:0002686)2.06380062
89Depressed nasal tip (HP:0000437)2.04683401
90Hypoplastic ischia (HP:0003175)2.04025117
91Hemiparesis (HP:0001269)2.03615782
92Aortic dissection (HP:0002647)2.01929318
93Hypotrichosis (HP:0001006)2.01587463
94Obstructive sleep apnea (HP:0002870)2.00049531
95Abnormal hemoglobin (HP:0011902)1.99616244
96Oligomenorrhea (HP:0000876)1.97774929
97Median cleft lip (HP:0000161)1.97343761
98Mitral stenosis (HP:0001718)1.96913825
99Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.96835975
100Dilatation of the ascending aorta (HP:0005111)1.96564410
101Soft skin (HP:0000977)1.94827035
102Stroke (HP:0001297)1.93854491
103Blue sclerae (HP:0000592)1.93448629
104Bell-shaped thorax (HP:0001591)1.92573389
105Amblyopia (HP:0000646)1.92461618
106Ventricular tachycardia (HP:0004756)1.92164919
107Abnormality of the anterior chamber (HP:0000593)1.91630691
108Plantar hyperkeratosis (HP:0007556)1.90898170
109Preaxial foot polydactyly (HP:0001841)1.90560595
110Abnormality of molar (HP:0011077)1.90462283
111Abnormality of molar morphology (HP:0011070)1.90462283
112Hydroxyprolinuria (HP:0003080)1.90374175
113Abnormality of proline metabolism (HP:0010907)1.90374175
114Osteoarthritis (HP:0002758)1.90179059
115Wide anterior fontanel (HP:0000260)1.89388227
116Striae distensae (HP:0001065)1.88437609
117Alopecia of scalp (HP:0002293)1.88094031
118Action tremor (HP:0002345)1.87273616
119Hypertriglyceridemia (HP:0002155)1.87045605
120Overgrowth (HP:0001548)1.86818197
121Conjunctival hamartoma (HP:0100780)1.86663049
122Abnormality of skeletal muscle fiber size (HP:0012084)1.86559037
123Hypophosphatemic rickets (HP:0004912)1.86338317
124Coronal craniosynostosis (HP:0004440)1.85910151
125Abnormality of Sharpey fibers (HP:0100685)1.84684024
126Hypodontia (HP:0000668)1.84422914
127Abnormal respiratory epithelium morphology (HP:0012253)1.83327829
128Abnormal respiratory motile cilium morphology (HP:0005938)1.83327829
129Metaphyseal cupping (HP:0003021)1.81900472
130Spondylolisthesis (HP:0003302)1.81648522
131Bilateral microphthalmos (HP:0007633)1.80620010
132Pterygium (HP:0001059)1.80340226
133Supraventricular arrhythmia (HP:0005115)1.79885446
134Distal lower limb muscle weakness (HP:0009053)1.79279620
135Complement deficiency (HP:0004431)1.78588216
136Myoglobinuria (HP:0002913)1.78400405
137Tibial bowing (HP:0002982)1.78015640
138Hyperparathyroidism (HP:0000843)1.77877724
139Muscle fiber splitting (HP:0003555)1.77809587
140Bone cyst (HP:0012062)1.76952665
141Congenital, generalized hypertrichosis (HP:0004540)1.76566753
142Torticollis (HP:0000473)1.76188342
143Choanal stenosis (HP:0000452)1.76100949
144Prominent supraorbital ridges (HP:0000336)1.75257433
145Synostosis of carpal bones (HP:0005048)1.75009783
146Neoplasm of the heart (HP:0100544)1.74858853
147Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.73664504
148Absent toe (HP:0010760)1.73647167
149Accelerated skeletal maturation (HP:0005616)1.73567697
150Narrow nasal bridge (HP:0000446)1.73528032
151Short nail (HP:0001799)1.73473040
152Hyporeflexia of lower limbs (HP:0002600)1.73083458
153Bowel diverticulosis (HP:0005222)1.72471029
154Palmoplantar hyperkeratosis (HP:0000972)1.72273100
155Abnormality of the dental root (HP:0006486)1.71502258
156Taurodontia (HP:0000679)1.71502258
157Abnormality of permanent molar morphology (HP:0011071)1.71502258
158Venous abnormality (HP:0002624)1.70856812
159Peritonitis (HP:0002586)1.70610243
160Hypoplasia of the iris (HP:0007676)1.70262870
161Central scotoma (HP:0000603)1.69725398
162Hypoplastic heart (HP:0001961)1.68692525
163Severe Myopia (HP:0011003)1.68495290
164Hyperextensible skin (HP:0000974)1.67888936
165Limited hip movement (HP:0008800)1.67866552
166Aneurysm (HP:0002617)1.67596095
167Down-sloping shoulders (HP:0200021)1.67299479

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB24.43503375
2SIK13.79985673
3MAPK153.79146480
4MST1R3.20530103
5CAMK1D2.90189099
6KSR12.68974471
7TRIB32.61472055
8LATS12.44298184
9FGFR22.38733652
10CAMK1G2.18176159
11MAP3K22.04281906
12LMTK22.01345602
13SIK32.00311630
14MAPK121.84019844
15MAPK71.75087903
16KIT1.71275629
17MARK11.70719238
18TIE11.70264663
19DDR21.62571270
20DMPK1.62080745
21PDK41.61838853
22PDK31.61838853
23PNCK1.61826835
24PDGFRB1.57419687
25LATS21.55414402
26ARAF1.49746547
27DAPK21.46647750
28MAP2K11.44180919
29CASK1.42221842
30NTRK31.41933634
31PDGFRA1.39468931
32FER1.38804553
33NTRK21.37298625
34BCKDK1.36932038
35ABL21.36881342
36KSR21.33941083
37BCR1.29801052
38MUSK1.29678766
39MET1.22855339
40CDK81.20726822
41EPHA41.11606891
42PDK21.07938313
43FGFR11.07606723
44MAP3K101.07516022
45PRKD31.02095238
46DAPK31.02005277
47MAPKAPK31.01714674
48ILK1.01478421
49MAPK41.01409442
50UHMK10.98861432
51ROCK20.97036725
52PAK20.96568610
53RIPK10.95957120
54PRKAA20.91417436
55STK390.90192755
56NTRK10.89624221
57ROCK10.88797816
58TAF10.84916685
59PRKG10.84644657
60PRKG20.83644135
61RAF10.83442506
62TESK10.83249784
63ERBB20.81871227
64CDK90.81439795
65CAMK2B0.79778182
66CDK30.79315776
67TTN0.76354993
68CDC42BPA0.76353076
69STK380.75242975
70GRK10.74471870
71MOS0.73800188
72CAMK2G0.73385931
73CAMKK10.72883112
74PINK10.71873111
75TYRO30.71639480
76MYLK0.70829412
77MAP3K90.70342275
78CDK120.69920309
79PAK30.69633490
80CAMK2A0.68698728
81TGFBR20.67083368
82PAK60.66855715
83TGFBR10.66851024
84STK38L0.66758405
85PKN10.66276779
86LRRK20.65648278
87INSRR0.65239581
88MAP3K120.65019571
89PTK2B0.62951176
90MAP3K30.62895512
91MARK20.61316973
92PHKG20.60854675
93PHKG10.60854675
94MAPKAPK50.60590032
95EEF2K0.60302893
96RIPK40.59504198
97PRKCE0.59448512
98PRKCG0.58283632
99MAP2K20.58254228
100PRPF4B0.56648675
101BMX0.56364547
102EPHA30.55454024
103ERBB40.55439641
104PIK3CA0.54699198
105ERN10.53914739
106RET0.52732488
107MAP3K10.51793918
108CDK150.51559703
109MAP2K40.51499936
110MINK10.51464983
111STK240.50831903
112SRC0.49656100
113IRAK10.48254506
114MAPK100.47563473
115PLK20.47378268
116RPS6KA20.47174662
117STK110.46972005
118CDK180.45540990
119CDK11A0.45497430
120CDK60.45059653
121PRKD10.44821426
122GSK3A0.44793004
123CAMK10.43983487
124MAP3K40.42457976
125BMPR1B0.41730217
126IGF1R0.41632900
127PIK3CG0.40915505
128PTK20.40904624
129PIM20.40801967
130IRAK20.39637170
131DYRK1A0.39309678
132CDK190.39001083
133FGFR30.38766581
134AKT20.38506968
135NEK90.38304237
136MAP3K130.36824097
137SGK2230.36601129
138EPHB10.36076031
139MAP3K60.35648844
140INSR0.35590279
141ADRBK10.34365948
142CDK50.33635516
143GRK50.33569823

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.11420767
2PPAR signaling pathway_Homo sapiens_hsa033203.10347864
3Fatty acid biosynthesis_Homo sapiens_hsa000612.97191845
4Fatty acid metabolism_Homo sapiens_hsa012122.71049923
5Basal cell carcinoma_Homo sapiens_hsa052172.71009614
6ECM-receptor interaction_Homo sapiens_hsa045122.43498315
7Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.41439464
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.34487227
9Fatty acid degradation_Homo sapiens_hsa000712.31027278
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.09375016
11Sulfur relay system_Homo sapiens_hsa041222.03224107
12Nitrogen metabolism_Homo sapiens_hsa009101.97410052
13Hedgehog signaling pathway_Homo sapiens_hsa043401.82916293
14Hippo signaling pathway_Homo sapiens_hsa043901.62288816
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.53281317
16Morphine addiction_Homo sapiens_hsa050321.50241366
17Melanogenesis_Homo sapiens_hsa049161.49829444
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.48094901
19Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.47438710
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.42836017
21Pyruvate metabolism_Homo sapiens_hsa006201.38289466
22Focal adhesion_Homo sapiens_hsa045101.34932792
23Wnt signaling pathway_Homo sapiens_hsa043101.30288128
24Nicotine addiction_Homo sapiens_hsa050331.28609921
25Axon guidance_Homo sapiens_hsa043601.27421325
26Adipocytokine signaling pathway_Homo sapiens_hsa049201.27401982
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.26557572
28TGF-beta signaling pathway_Homo sapiens_hsa043501.26199619
29Fatty acid elongation_Homo sapiens_hsa000621.25896458
30Cocaine addiction_Homo sapiens_hsa050301.22560356
31Protein digestion and absorption_Homo sapiens_hsa049741.21823648
32Long-term potentiation_Homo sapiens_hsa047201.21676029
33Renin secretion_Homo sapiens_hsa049241.20804125
34Proteoglycans in cancer_Homo sapiens_hsa052051.19786053
35Insulin secretion_Homo sapiens_hsa049111.18164713
36Phospholipase D signaling pathway_Homo sapiens_hsa040721.18160607
37AMPK signaling pathway_Homo sapiens_hsa041521.13928347
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.11422956
39Synaptic vesicle cycle_Homo sapiens_hsa047211.09000641
40Glycerolipid metabolism_Homo sapiens_hsa005611.08215778
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06446697
42Dilated cardiomyopathy_Homo sapiens_hsa054141.05967619
43Gastric acid secretion_Homo sapiens_hsa049711.03952137
44AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.02791290
45Cholinergic synapse_Homo sapiens_hsa047251.02466404
46Histidine metabolism_Homo sapiens_hsa003401.02276956
47Butanoate metabolism_Homo sapiens_hsa006501.00625043
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.00264724
49Insulin resistance_Homo sapiens_hsa049311.00098615
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.97347994
51Amoebiasis_Homo sapiens_hsa051460.96641711
52Platelet activation_Homo sapiens_hsa046110.95034517
53Folate biosynthesis_Homo sapiens_hsa007900.94902119
54Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.94240049
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93516750
56Dorso-ventral axis formation_Homo sapiens_hsa043200.93447115
57Notch signaling pathway_Homo sapiens_hsa043300.93227284
582-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91857032
59Salivary secretion_Homo sapiens_hsa049700.91155067
60Glucagon signaling pathway_Homo sapiens_hsa049220.89739729
61beta-Alanine metabolism_Homo sapiens_hsa004100.89601231
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86944972
63Insulin signaling pathway_Homo sapiens_hsa049100.86636609
64Dopaminergic synapse_Homo sapiens_hsa047280.86509773
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.86271857
66Carbon metabolism_Homo sapiens_hsa012000.83142059
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.82754832
68Bile secretion_Homo sapiens_hsa049760.82129635
69Melanoma_Homo sapiens_hsa052180.80991665
70Pathways in cancer_Homo sapiens_hsa052000.80183264
71Serotonergic synapse_Homo sapiens_hsa047260.79428139
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79115962
73Estrogen signaling pathway_Homo sapiens_hsa049150.78591832
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77262029
75Circadian entrainment_Homo sapiens_hsa047130.76878694
76Olfactory transduction_Homo sapiens_hsa047400.75756158
77Adherens junction_Homo sapiens_hsa045200.74898350
78cAMP signaling pathway_Homo sapiens_hsa040240.74291705
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73561467
80PI3K-Akt signaling pathway_Homo sapiens_hsa041510.73231231
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73094567
82Pancreatic secretion_Homo sapiens_hsa049720.72471761
83Calcium signaling pathway_Homo sapiens_hsa040200.69289453
84GnRH signaling pathway_Homo sapiens_hsa049120.68522204
85Circadian rhythm_Homo sapiens_hsa047100.67348747
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66789728
87Complement and coagulation cascades_Homo sapiens_hsa046100.64630307
88ErbB signaling pathway_Homo sapiens_hsa040120.64245389
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.62830052
90Rap1 signaling pathway_Homo sapiens_hsa040150.62754717
91Ras signaling pathway_Homo sapiens_hsa040140.62326202
92Tight junction_Homo sapiens_hsa045300.62255023
93Choline metabolism in cancer_Homo sapiens_hsa052310.61826583
94Thyroid hormone synthesis_Homo sapiens_hsa049180.61657943
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61598485
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60860649
97Gap junction_Homo sapiens_hsa045400.60858341
98Small cell lung cancer_Homo sapiens_hsa052220.60033958
99Peroxisome_Homo sapiens_hsa041460.59360586
100Oxytocin signaling pathway_Homo sapiens_hsa049210.59345230
101Bladder cancer_Homo sapiens_hsa052190.58748215
102Chemical carcinogenesis_Homo sapiens_hsa052040.58065991
103Renal cell carcinoma_Homo sapiens_hsa052110.56696671
104Phenylalanine metabolism_Homo sapiens_hsa003600.56504071
105Type II diabetes mellitus_Homo sapiens_hsa049300.55721602
106Glioma_Homo sapiens_hsa052140.55152236
107Glutathione metabolism_Homo sapiens_hsa004800.54632139
108Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52775511
109Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52705010
110Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.51968397
111Glutamatergic synapse_Homo sapiens_hsa047240.51424846
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51382097
113Fat digestion and absorption_Homo sapiens_hsa049750.50409093
114MAPK signaling pathway_Homo sapiens_hsa040100.48771313
115Ovarian steroidogenesis_Homo sapiens_hsa049130.48313539
116Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47657901
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.47353062
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.47335851
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47296526
120Phototransduction_Homo sapiens_hsa047440.46979516
121Long-term depression_Homo sapiens_hsa047300.46310067
122Tyrosine metabolism_Homo sapiens_hsa003500.45878148
123Taste transduction_Homo sapiens_hsa047420.45368200
124VEGF signaling pathway_Homo sapiens_hsa043700.43851300
125Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43601624
126Cardiac muscle contraction_Homo sapiens_hsa042600.43060791
127MicroRNAs in cancer_Homo sapiens_hsa052060.42891940
128Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42154770
129Amphetamine addiction_Homo sapiens_hsa050310.41468316
130Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41031532
131GABAergic synapse_Homo sapiens_hsa047270.40096188
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39601200
133Prion diseases_Homo sapiens_hsa050200.38672141
134Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37884484

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