CCDC28A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a coiled-coil domain containing protein. Although the specific function of this gene has not yet been determined, this gene is a known translocation partner of nucleoporin 98 in acute leukemias. The resulting fusion gene produces a nucleoporin 98-coiled-coil domain-containing protein 28A chimeric protein which may be involved in promoting myeloproliferative neoplasms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.74277590
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.37776038
3energy coupled proton transport, down electrochemical gradient (GO:0015985)4.92867400
4ATP synthesis coupled proton transport (GO:0015986)4.92867400
5respiratory electron transport chain (GO:0022904)4.92038220
6electron transport chain (GO:0022900)4.85002780
7immunoglobulin mediated immune response (GO:0016064)4.80410247
8succinate metabolic process (GO:0006105)4.73086452
9neutrophil activation involved in immune response (GO:0002283)4.68163175
10protein complex biogenesis (GO:0070271)4.65781284
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.54343705
12mitochondrial respiratory chain complex assembly (GO:0033108)4.25431999
13oxaloacetate metabolic process (GO:0006107)4.25198370
14regulation of B cell receptor signaling pathway (GO:0050855)4.15855367
15positive regulation of gamma-delta T cell activation (GO:0046645)3.98067726
16B cell mediated immunity (GO:0019724)3.95548402
17dopamine transport (GO:0015872)3.95491700
18chaperone-mediated protein transport (GO:0072321)3.85971133
19antigen processing and presentation of endogenous antigen (GO:0019883)3.81123778
20protein localization to cilium (GO:0061512)3.74025705
21positive regulation of B cell differentiation (GO:0045579)3.70822004
22regulation of oxidative phosphorylation (GO:0002082)3.66435584
23negative regulation of dendrite morphogenesis (GO:0050774)3.61800934
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.57137360
25mitochondrial respiratory chain complex I assembly (GO:0032981)3.57137360
26NADH dehydrogenase complex assembly (GO:0010257)3.57137360
27neuromuscular process controlling posture (GO:0050884)3.55903618
28regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.51795713
29DNA deamination (GO:0045006)3.50288247
30neuron cell-cell adhesion (GO:0007158)3.49839880
31negative regulation of cell killing (GO:0031342)3.49233527
32negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.49233527
33antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.48968841
34cytidine deamination (GO:0009972)3.47084012
35cytidine metabolic process (GO:0046087)3.47084012
36cytidine catabolic process (GO:0006216)3.47084012
37inner mitochondrial membrane organization (GO:0007007)3.46669125
38positive regulation of mitochondrial fission (GO:0090141)3.45143501
39neuronal action potential propagation (GO:0019227)3.43658445
40ATP biosynthetic process (GO:0006754)3.43250626
41respiratory chain complex IV assembly (GO:0008535)3.40818544
42establishment of protein localization to mitochondrial membrane (GO:0090151)3.38992690
43hydrogen ion transmembrane transport (GO:1902600)3.38778535
44negative regulation of erythrocyte differentiation (GO:0045647)3.38768949
45interferon-gamma-mediated signaling pathway (GO:0060333)3.38527939
46response to peptidoglycan (GO:0032494)3.34297255
47oxidative phosphorylation (GO:0006119)3.33640758
48metallo-sulfur cluster assembly (GO:0031163)3.29527954
49iron-sulfur cluster assembly (GO:0016226)3.29527954
50valine metabolic process (GO:0006573)3.29242178
51neutrophil activation (GO:0042119)3.27106503
52synaptic vesicle exocytosis (GO:0016079)3.23075100
53ATP hydrolysis coupled proton transport (GO:0015991)3.22552601
54energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.22552601
55purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.22318964
56purine nucleoside triphosphate biosynthetic process (GO:0009145)3.20016166
57positive regulation of mast cell activation (GO:0033005)3.19857838
58regulation of mitochondrial translation (GO:0070129)3.19692715
59granulocyte activation (GO:0036230)3.17017105
60inositol phosphate catabolic process (GO:0071545)3.15429960
61antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.14458884
62NADH metabolic process (GO:0006734)3.14356769
63regulation of B cell differentiation (GO:0045577)3.13176909
64positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.11896021
65positive regulation of mast cell degranulation (GO:0043306)3.08062809
66positive regulation of mast cell activation involved in immune response (GO:0033008)3.08062809
67response to interferon-beta (GO:0035456)3.07275237
68regulation of regulatory T cell differentiation (GO:0045589)3.05185745
69Arp2/3 complex-mediated actin nucleation (GO:0034314)3.05157855
70cytochrome complex assembly (GO:0017004)3.04893019
71regulation of cilium movement (GO:0003352)3.04539169
72phosphorylated carbohydrate dephosphorylation (GO:0046838)3.04505869
73inositol phosphate dephosphorylation (GO:0046855)3.04505869
74myeloid cell activation involved in immune response (GO:0002275)3.02321256
75negative regulation of interleukin-12 production (GO:0032695)3.00358911
76proton transport (GO:0015992)2.99554471
77regulation of mast cell activation (GO:0033003)2.97392219
78peptidyl-arginine omega-N-methylation (GO:0035247)2.96157797
79hydrogen transport (GO:0006818)2.95259847
80regulation of protein kinase A signaling (GO:0010738)2.95172232
81positive thymic T cell selection (GO:0045059)2.93320343
82positive regulation of antigen processing and presentation (GO:0002579)2.90383850
83catecholamine transport (GO:0051937)2.89226186
84regulation of mast cell degranulation (GO:0043304)2.89189218
85pyrimidine ribonucleoside catabolic process (GO:0046133)2.88085987
86detection of bacterium (GO:0016045)2.86069432
87termination of RNA polymerase III transcription (GO:0006386)2.84802034
88transcription elongation from RNA polymerase III promoter (GO:0006385)2.84802034
89detection of other organism (GO:0098543)2.84688379
90protein neddylation (GO:0045116)2.82672668
91aerobic respiration (GO:0009060)2.81996350
92autophagic vacuole fusion (GO:0000046)2.81781488
93negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.81270688
94tricarboxylic acid cycle (GO:0006099)2.81165943
95regulation of gamma-delta T cell activation (GO:0046643)2.79579233
96ribonucleoside triphosphate biosynthetic process (GO:0009201)2.78717194
97calcium ion-dependent exocytosis (GO:0017156)2.78303915
98regulation of antigen processing and presentation (GO:0002577)2.78230333
99regulation of acyl-CoA biosynthetic process (GO:0050812)2.77132983
100mast cell activation (GO:0045576)2.76258721
101purine deoxyribonucleotide catabolic process (GO:0009155)2.75144019
102leukocyte degranulation (GO:0043299)2.73242362
103acrosome reaction (GO:0007340)2.72517574
104regulation of germinal center formation (GO:0002634)2.71268704
105phospholipid scrambling (GO:0017121)2.70819292
106regulation of tolerance induction (GO:0002643)2.70736078
107transferrin transport (GO:0033572)2.70667862
108antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.70281354
109purine nucleotide salvage (GO:0032261)2.69352810
110actin nucleation (GO:0045010)2.66417709
111regulation of cellular respiration (GO:0043457)2.65984435
112regulation of mast cell activation involved in immune response (GO:0033006)2.65671199
113microglial cell activation (GO:0001774)2.65100887
114cellular response to interferon-gamma (GO:0071346)2.63762778
115calcium-mediated signaling using intracellular calcium source (GO:0035584)2.63642694
116regulation of alpha-beta T cell proliferation (GO:0046640)2.63428526
117cellular response to type I interferon (GO:0071357)2.62616977
118type I interferon signaling pathway (GO:0060337)2.62616977
119antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.62002828
120protein localization to synapse (GO:0035418)2.61273955
121polyol catabolic process (GO:0046174)2.61260609
122regulation of B cell apoptotic process (GO:0002902)2.60961282
123positive regulation of type 2 immune response (GO:0002830)2.59460261
124regulation of gamma-delta T cell differentiation (GO:0045586)2.59428648
125organelle membrane fusion (GO:0090174)2.59357073
126aldehyde catabolic process (GO:0046185)2.58927548
127macrophage activation involved in immune response (GO:0002281)2.56830512
128modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.55956726
129positive regulation by organism of defense response of other organism involved in symbiotic interact2.55956726
130modulation by symbiont of host immune response (GO:0052553)2.55956726
131positive regulation by symbiont of host defense response (GO:0052509)2.55956726
132modulation by symbiont of host defense response (GO:0052031)2.55956726
133modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.55956726
134response to type I interferon (GO:0034340)2.55940439
135regulation of T cell mediated cytotoxicity (GO:0001914)2.55861205
136peptidyl-arginine methylation (GO:0018216)2.55481529
137peptidyl-arginine N-methylation (GO:0035246)2.55481529
138peroxisome fission (GO:0016559)2.55253313
139regulation of mitochondrial fission (GO:0090140)2.55195422
140proteasome assembly (GO:0043248)2.54859427
141positive T cell selection (GO:0043368)2.53991563
142regulation of glutamate secretion (GO:0014048)2.52972584
143negative regulation of dendrite development (GO:2000171)2.52154103
144axonemal dynein complex assembly (GO:0070286)2.50760963
145neurotransmitter uptake (GO:0001504)2.50758788
146response to interferon-gamma (GO:0034341)2.49338258
147GTP biosynthetic process (GO:0006183)2.49058147
148nucleoside triphosphate biosynthetic process (GO:0009142)2.48608793
149trivalent inorganic cation transport (GO:0072512)2.47530320
150ferric iron transport (GO:0015682)2.47530320
151positive regulation of T cell mediated cytotoxicity (GO:0001916)2.47434373
152purine-containing compound salvage (GO:0043101)2.47121260
153L-phenylalanine metabolic process (GO:0006558)2.46021574
154erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.46021574
155T cell costimulation (GO:0031295)2.45866830
156detection of external biotic stimulus (GO:0098581)2.44567993
157regulation of coenzyme metabolic process (GO:0051196)2.43959324
158regulation of cofactor metabolic process (GO:0051193)2.43959324
159regulation of catecholamine metabolic process (GO:0042069)2.43760289
160regulation of dopamine metabolic process (GO:0042053)2.43760289
161B cell receptor signaling pathway (GO:0050853)2.43738982
162lymphocyte costimulation (GO:0031294)2.42378103
163respiratory burst (GO:0045730)2.42134221
164dopamine biosynthetic process (GO:0042416)2.42081053
165guanosine-containing compound biosynthetic process (GO:1901070)2.41895118
166glutamate secretion (GO:0014047)2.41256359
167negative regulation of B cell proliferation (GO:0030889)2.41238884
168erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.40578655
169L-phenylalanine catabolic process (GO:0006559)2.40578655
170vocalization behavior (GO:0071625)2.39970503
171negative regulation of lymphocyte mediated immunity (GO:0002707)2.39788100
172GDP-mannose metabolic process (GO:0019673)2.38779016
173epithelial cilium movement (GO:0003351)2.38574221
174negative regulation of synaptic transmission, GABAergic (GO:0032229)2.38509745
175histamine secretion (GO:0001821)2.38437427
176cellular ketone body metabolic process (GO:0046950)2.38337860
177behavioral response to cocaine (GO:0048148)2.38274623
178positive regulation of interleukin-17 production (GO:0032740)2.38049078
179leukocyte aggregation (GO:0070486)2.37513333
180mucosal-associated lymphoid tissue development (GO:0048537)2.36719896
181Peyers patch development (GO:0048541)2.36719896
182sperm motility (GO:0030317)2.36689294
183histone arginine methylation (GO:0034969)2.36469476
184regulation of T cell tolerance induction (GO:0002664)2.36441985
185antigen receptor-mediated signaling pathway (GO:0050851)2.36217868
186positive regulation of tolerance induction (GO:0002645)2.35459117
187positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.33327913
188positive regulation of interleukin-1 beta secretion (GO:0050718)2.33112746
189T cell migration (GO:0072678)2.33098990
190regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.33075121
191detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.32890875
192NIK/NF-kappaB signaling (GO:0038061)2.32748649
193positive regulation of granulocyte differentiation (GO:0030854)2.31601360
194positive regulation of interleukin-8 secretion (GO:2000484)2.31174269
195regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.29896480
196lymphocyte chemotaxis (GO:0048247)2.29552368
197fusion of sperm to egg plasma membrane (GO:0007342)2.29533114
198tolerance induction (GO:0002507)2.28155701
199regulation of myeloid leukocyte mediated immunity (GO:0002886)2.27011642

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.56760878
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.73947260
3EZH2_22144423_ChIP-Seq_EOC_Human4.60251772
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.22790031
5TAF15_26573619_Chip-Seq_HEK293_Human3.77857897
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.41901212
7ELF1_17652178_ChIP-ChIP_JURKAT_Human3.31334299
8GATA1_22025678_ChIP-Seq_K562_Human3.28662273
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.18164296
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.92783707
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.82458562
12ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.74315642
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.65675388
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.63984811
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.58157507
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.47652774
17SPI1_23547873_ChIP-Seq_NB4_Human2.46274626
18CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.42631158
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.39808339
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.39648995
21MYB_26560356_Chip-Seq_TH2_Human2.37888873
22* GABP_17652178_ChIP-ChIP_JURKAT_Human2.24692400
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.18662932
24GBX2_23144817_ChIP-Seq_PC3_Human2.12182938
25* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09681547
26RUNX_20019798_ChIP-Seq_JUKART_Human2.08345195
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.05870661
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.03032828
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.02930338
30SCL_19346495_ChIP-Seq_HPC-7_Human2.01420277
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.95968760
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.92992097
33REST_21632747_ChIP-Seq_MESCs_Mouse1.89857693
34GATA3_26560356_Chip-Seq_TH2_Human1.80575345
35PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.75766459
36* EST1_17652178_ChIP-ChIP_JURKAT_Human1.75572266
37ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.75535320
38MYB_26560356_Chip-Seq_TH1_Human1.71771704
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.70470607
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69010688
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68755558
42* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68714062
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.67290320
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65879750
45GATA3_27048872_Chip-Seq_THYMUS_Human1.65675905
46IGF1R_20145208_ChIP-Seq_DFB_Human1.65250154
47STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.62569255
48P300_19829295_ChIP-Seq_ESCs_Human1.62405539
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61262617
50ZNF274_21170338_ChIP-Seq_K562_Hela1.60029462
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59139144
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58779687
53* ETS1_20019798_ChIP-Seq_JURKAT_Human1.55904041
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.55364892
55REST_18959480_ChIP-ChIP_MESCs_Mouse1.51748084
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.51703964
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51288728
58SPI1_23127762_ChIP-Seq_K562_Human1.51250330
59CTCF_18555785_ChIP-Seq_MESCs_Mouse1.50851314
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.46780003
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46048750
62EGR1_23403033_ChIP-Seq_LIVER_Mouse1.45860830
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.43909093
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.43187632
65VDR_24787735_ChIP-Seq_THP-1_Human1.43081713
66HTT_18923047_ChIP-ChIP_STHdh_Human1.39859150
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.38224062
68IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35566922
69SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34454592
70CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33043181
71FUS_26573619_Chip-Seq_HEK293_Human1.31996884
72GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.30252441
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27695430
74STAT1_20625510_ChIP-Seq_HELA_Human1.26575829
75* SMAD4_21799915_ChIP-Seq_A2780_Human1.26082070
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25782125
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23755287
78PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.23401378
79BMI1_23680149_ChIP-Seq_NPCS_Mouse1.22113933
80VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.21657324
81TAL1_26923725_Chip-Seq_HPCs_Mouse1.20779047
82Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.20511019
83E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19627606
84UTX_26944678_Chip-Seq_JUKART_Human1.18866813
85MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.17336866
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.17038975
87RUNX1_22412390_ChIP-Seq_EML_Mouse1.16291896
88FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14664448
89VDR_24763502_ChIP-Seq_THP-1_Human1.14540196
90TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13822142
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.13786169
92VDR_23849224_ChIP-Seq_CD4+_Human1.12111610
93SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11558656
94SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.10414936
95SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.09942674
96MAF_26560356_Chip-Seq_TH1_Human1.09469196
97SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08109719
98CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07392005
99THAP11_20581084_ChIP-Seq_MESCs_Mouse1.06977273
100GATA3_26560356_Chip-Seq_TH1_Human1.06430010
101ELF1_20517297_ChIP-Seq_JURKAT_Human1.06206423
102GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06072602
103CREB1_15753290_ChIP-ChIP_HEK293T_Human1.05853504
104ERG_20517297_ChIP-Seq_VCAP_Human1.05031927
105AR_25329375_ChIP-Seq_VCAP_Human1.05015313
106* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04881101
107STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04782869
108RARB_27405468_Chip-Seq_BRAIN_Mouse1.04330728
109CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04168629
110BCL6_27268052_Chip-Seq_Bcells_Human1.03505527
111ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03290485
112SMRT_27268052_Chip-Seq_Bcells_Human1.03128947
113CIITA_25753668_ChIP-Seq_RAJI_Human1.02939594
114MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02662629
115REST_19997604_ChIP-ChIP_NEURONS_Mouse1.02576668
116* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02357234
117JARID2_20064375_ChIP-Seq_MESCs_Mouse1.01539999
118EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00737814
119AR_20517297_ChIP-Seq_VCAP_Human1.00714951
120IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00467279
121YY1_21170310_ChIP-Seq_MESCs_Mouse1.00248838
122TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98634192
123SOX2_19829295_ChIP-Seq_ESCs_Human0.98453751
124NANOG_19829295_ChIP-Seq_ESCs_Human0.98453751
125CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.98255083
126SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.98066325
127UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97649603
128NANOG_20526341_ChIP-Seq_ESCs_Human0.95806327
129FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95726768
130GATA3_21867929_ChIP-Seq_TH1_Mouse0.95625568
131CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.95422405
132SALL4_22934838_ChIP-ChIP_CD34+_Human0.95054484
133NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93549150
134MTF2_20144788_ChIP-Seq_MESCs_Mouse0.93113114
135RNF2_27304074_Chip-Seq_NSC_Mouse0.92970775
136P300_27268052_Chip-Seq_Bcells_Human0.91432781
137GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.91259511
138* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.91174448
139PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89872064
140TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89638291
141KDM2B_26808549_Chip-Seq_REH_Human0.89552246
142IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89407502
143CBP_20019798_ChIP-Seq_JUKART_Human0.89407502
144SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89377620
145FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89246838
146FOXA1_25329375_ChIP-Seq_VCAP_Human0.89246838
147ELK1_19687146_ChIP-ChIP_HELA_Human0.89214196
148IRF1_19129219_ChIP-ChIP_H3396_Human0.88205117
149ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.88074562
150GATA3_21878914_ChIP-Seq_MCF-7_Human0.87903179
151VDR_22108803_ChIP-Seq_LS180_Human0.87651774
152TFEB_21752829_ChIP-Seq_HELA_Human0.87469702
153CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86819695
154CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86640734
155GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.86367998
156RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86093447
157SOX2_22085726_ChIP-Seq_NPCs_Mouse0.86055277
158NR3C1_23031785_ChIP-Seq_PC12_Mouse0.85665365
159FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.85657088
160FOXP3_21729870_ChIP-Seq_TREG_Human0.85614281
161MYC_18940864_ChIP-ChIP_HL60_Human0.85386044
162PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.84533836
163ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84221175
164NCOR_22424771_ChIP-Seq_293T_Human0.83576922
165PRDM14_20953172_ChIP-Seq_ESCs_Human0.83499722
166HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.82810983
167RXR_22158963_ChIP-Seq_LIVER_Mouse0.82078976
168* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.81558580
169HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80419757
170EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.80173684
171CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.80059243

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.12343715
2MP0003724_increased_susceptibility_to3.71737666
3MP0003880_abnormal_central_pattern3.69099988
4MP0001986_abnormal_taste_sensitivity3.32644087
5MP0005671_abnormal_response_to3.24382872
6MP0009785_altered_susceptibility_to2.95353064
7MP0006276_abnormal_autonomic_nervous2.83115962
8MP0001968_abnormal_touch/_nociception2.77657917
9MP0002736_abnormal_nociception_after2.70344368
10MP0003436_decreased_susceptibility_to2.69158780
11MP0004270_analgesia2.64662643
12MP0005000_abnormal_immune_tolerance2.62788240
13MP0003303_peritoneal_inflammation2.62716804
14MP0004859_abnormal_synaptic_plasticity2.60281002
15MP0002148_abnormal_hypersensitivity_rea2.59621964
16MP0001800_abnormal_humoral_immune2.59210930
17MP0002139_abnormal_hepatobiliary_system2.50880961
18MP0005025_abnormal_response_to2.48893436
19MP0002735_abnormal_chemical_nociception2.46404845
20MP0009379_abnormal_foot_pigmentation2.44490746
21MP0003635_abnormal_synaptic_transmissio2.42619278
22MP0008875_abnormal_xenobiotic_pharmacok2.42337369
23MP0005410_abnormal_fertilization2.41918869
24MP0002419_abnormal_innate_immunity2.37231197
25MP0002723_abnormal_immune_serum2.36784142
26MP0001790_abnormal_immune_system2.35478385
27MP0005387_immune_system_phenotype2.35478385
28MP0009745_abnormal_behavioral_response2.34551606
29MP0002452_abnormal_antigen_presenting2.32628058
30MP0006082_CNS_inflammation2.29205361
31MP0001905_abnormal_dopamine_level2.28808355
32MP0006036_abnormal_mitochondrial_physio2.27253979
33MP0005464_abnormal_platelet_physiology2.26778350
34MP0001819_abnormal_immune_cell2.23340968
35MP0002420_abnormal_adaptive_immunity2.23103987
36MP0001529_abnormal_vocalization2.22045524
37MP0002272_abnormal_nervous_system2.17418122
38MP0006035_abnormal_mitochondrial_morpho2.16167385
39MP0002822_catalepsy2.14181581
40MP0000685_abnormal_immune_system2.11651558
41MP0009046_muscle_twitch2.10169425
42MP0002734_abnormal_mechanical_nocicepti2.02763154
43MP0001501_abnormal_sleep_pattern2.01790595
44MP0002064_seizures2.01139222
45MP0005085_abnormal_gallbladder_physiolo2.00781452
46MP0002733_abnormal_thermal_nociception1.99715421
47MP0002876_abnormal_thyroid_physiology1.99587235
48MP0005360_urolithiasis1.92477156
49MP0005365_abnormal_bile_salt1.91155000
50MP0001984_abnormal_olfaction1.89899298
51MP0002396_abnormal_hematopoietic_system1.88062559
52MP0002837_dystrophic_cardiac_calcinosis1.84986368
53MP0002572_abnormal_emotion/affect_behav1.82932827
54MP0001970_abnormal_pain_threshold1.78083044
55MP0009333_abnormal_splenocyte_physiolog1.77717509
56MP0009764_decreased_sensitivity_to1.77703774
57MP0002138_abnormal_hepatobiliary_system1.75505565
58MP0002398_abnormal_bone_marrow1.75462307
59MP0009697_abnormal_copulation1.74745959
60MP0000716_abnormal_immune_system1.72453454
61MP0001845_abnormal_inflammatory_respons1.71613831
62MP0010155_abnormal_intestine_physiology1.70994076
63MP0002063_abnormal_learning/memory/cond1.70655040
64MP0002132_abnormal_respiratory_system1.68190843
65MP0002405_respiratory_system_inflammati1.67632900
66MP0001188_hyperpigmentation1.61927282
67MP0004147_increased_porphyrin_level1.61804000
68MP0002067_abnormal_sensory_capabilities1.61180466
69MP0000689_abnormal_spleen_morphology1.61052822
70MP0002277_abnormal_respiratory_mucosa1.58564028
71MP0001853_heart_inflammation1.58474251
72MP0008469_abnormal_protein_level1.52533807
73MP0004142_abnormal_muscle_tone1.49046144
74MP0002722_abnormal_immune_system1.43644741
75MP0002429_abnormal_blood_cell1.41543922
76MP0005535_abnormal_body_temperature1.39384335
77MP0005397_hematopoietic_system_phenotyp1.37888880
78MP0001545_abnormal_hematopoietic_system1.37888880
79MP0001533_abnormal_skeleton_physiology1.37554007
80MP0002254_reproductive_system_inflammat1.37415826
81MP0001440_abnormal_grooming_behavior1.37199504
82MP0008872_abnormal_physiological_respon1.37071523
83MP0003763_abnormal_thymus_physiology1.36973237
84MP0005423_abnormal_somatic_nervous1.36203132
85MP0003075_altered_response_to1.35625295
86MP0004924_abnormal_behavior1.32154003
87MP0005386_behavior/neurological_phenoty1.32154003
88MP0001486_abnormal_startle_reflex1.30908492
89MP0003879_abnormal_hair_cell1.27998585
90MP0003866_abnormal_defecation1.27778189
91MP0003646_muscle_fatigue1.26904292
92MP0005379_endocrine/exocrine_gland_phen1.26451228
93MP0000465_gastrointestinal_hemorrhage1.24439332
94MP0008874_decreased_physiological_sensi1.17896567
95MP0002184_abnormal_innervation1.15273883
96MP0000703_abnormal_thymus_morphology1.12015708
97MP0003656_abnormal_erythrocyte_physiolo1.10591807
98MP0009763_increased_sensitivity_to1.10591405
99MP0000372_irregular_coat_pigmentation1.09940934
100MP0002163_abnormal_gland_morphology1.07534673
101MP0005636_abnormal_mineral_homeostasis1.06664527
102MP0002557_abnormal_social/conspecific_i1.05056580
103MP0005166_decreased_susceptibility_to1.05036459
104MP0001764_abnormal_homeostasis1.03259401
105MP0000343_altered_response_to1.02711624
106MP0005646_abnormal_pituitary_gland1.02540460
107MP0005058_abnormal_lysosome_morphology1.02336306
108MP0003172_abnormal_lysosome_physiology1.00953146
109MP0008877_abnormal_DNA_methylation0.99268124
110MP0003329_amyloid_beta_deposits0.97046869
111MP0003806_abnormal_nucleotide_metabolis0.96887782
112MP0003698_abnormal_male_reproductive0.96887462
113MP0010329_abnormal_lipoprotein_level0.96463856
114MP0010386_abnormal_urinary_bladder0.92511365
115MP0002166_altered_tumor_susceptibility0.92355140
116MP0008004_abnormal_stomach_pH0.90957529
117MP0004484_altered_response_of0.89891866
118MP0000858_altered_metastatic_potential0.89526767
119MP0005310_abnormal_salivary_gland0.88922487
120MP0003718_maternal_effect0.88906986
121MP0001664_abnormal_digestion0.88772207
122MP0002009_preneoplasia0.88320347
123MP0008569_lethality_at_weaning0.87433071
124MP0005584_abnormal_enzyme/coenzyme_acti0.87426491
125MP0000358_abnormal_cell_content/0.87322655
126MP0001502_abnormal_circadian_rhythm0.87099626
127MP0003195_calcinosis0.86879938
128MP0002229_neurodegeneration0.86150185
129MP0001873_stomach_inflammation0.85936487
130MP0005084_abnormal_gallbladder_morpholo0.85728937
131MP0009765_abnormal_xenobiotic_induced0.85619942
132MP0003011_delayed_dark_adaptation0.85318129
133MP0004145_abnormal_muscle_electrophysio0.84045246
134MP0003448_altered_tumor_morphology0.83528832
135MP0002066_abnormal_motor_capabilities/c0.83456448
136MP0003186_abnormal_redox_activity0.83221132
137MP0005647_abnormal_sex_gland0.83080304
138MP0003191_abnormal_cellular_cholesterol0.82806274
139MP0005645_abnormal_hypothalamus_physiol0.81708211
140MP0005319_abnormal_enzyme/_coenzyme0.80680916
141MP0002332_abnormal_exercise_endurance0.79897535
142MP0001929_abnormal_gametogenesis0.79840499
143MP0003868_abnormal_feces_composition0.79321108
144MP0005332_abnormal_amino_acid0.77677522
145MP0003252_abnormal_bile_duct0.74896241
146MP0001765_abnormal_ion_homeostasis0.74887550
147MP0008058_abnormal_DNA_repair0.74678391
148MP0003787_abnormal_imprinting0.74587227
149MP0005376_homeostasis/metabolism_phenot0.73903293
150MP0004947_skin_inflammation0.73476749
151MP0000751_myopathy0.73256092
152MP0000678_abnormal_parathyroid_gland0.73151579
153MP0003638_abnormal_response/metabolism_0.72963697
154MP0000230_abnormal_systemic_arterial0.72167200
155MP0004036_abnormal_muscle_relaxation0.71906224
156MP0002102_abnormal_ear_morphology0.71782236
157MP0008873_increased_physiological_sensi0.71553101
158MP0002019_abnormal_tumor_incidence0.71314358
159MP0002693_abnormal_pancreas_physiology0.70654620
160MP0002909_abnormal_adrenal_gland0.70634376
161MP0009643_abnormal_urine_homeostasis0.70006790
162MP0001663_abnormal_digestive_system0.68474439
163MP0005075_abnormal_melanosome_morpholog0.66659141
164MP0005083_abnormal_biliary_tract0.65717100
165MP0004811_abnormal_neuron_physiology0.65586924
166MP0005266_abnormal_metabolism0.65569099
167MP0002069_abnormal_eating/drinking_beha0.64840824
168MP0005551_abnormal_eye_electrophysiolog0.64726770
169MP0005389_reproductive_system_phenotype0.64440709
170MP0002998_abnormal_bone_remodeling0.64040930
171MP0000955_abnormal_spinal_cord0.63036627

Predicted human phenotypes

RankGene SetZ-score
1Abnormal mitochondria in muscle tissue (HP:0008316)5.11471409
2Acute necrotizing encephalopathy (HP:0006965)4.76567979
3Mitochondrial inheritance (HP:0001427)4.70715132
4Hepatocellular necrosis (HP:0001404)4.46470925
5Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.44574603
6Decreased activity of mitochondrial respiratory chain (HP:0008972)4.44574603
7Increased intramyocellular lipid droplets (HP:0012240)4.31017133
8Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.24343566
9Acute encephalopathy (HP:0006846)4.23464069
10Muscle abnormality related to mitochondrial dysfunction (HP:0003800)4.05562759
11Progressive macrocephaly (HP:0004481)4.04600800
12Focal motor seizures (HP:0011153)4.00972712
13Increased CSF lactate (HP:0002490)3.99025016
14Hypothermia (HP:0002045)3.96743445
15Hepatic necrosis (HP:0002605)3.84850603
16Recurrent abscess formation (HP:0002722)3.77398648
17Increased muscle lipid content (HP:0009058)3.71933269
18Recurrent bacterial skin infections (HP:0005406)3.64141962
19Stomatitis (HP:0010280)3.61202173
20Elevated erythrocyte sedimentation rate (HP:0003565)3.52609834
21Myokymia (HP:0002411)3.52379064
22Increased hepatocellular lipid droplets (HP:0006565)3.52079299
23Atonic seizures (HP:0010819)3.49546765
24Abnormal hair whorl (HP:0010721)3.47610013
25Obstructive lung disease (HP:0006536)3.45515550
26Chronic obstructive pulmonary disease (HP:0006510)3.45515550
27Ragged-red muscle fibers (HP:0003200)3.41364577
28Absent/shortened dynein arms (HP:0200106)3.39822407
29Dynein arm defect of respiratory motile cilia (HP:0012255)3.39822407
30Lactic acidosis (HP:0003128)3.34495620
31Lipid accumulation in hepatocytes (HP:0006561)3.23274351
32Renal Fanconi syndrome (HP:0001994)3.17873779
33Cerebral edema (HP:0002181)3.17339696
34Abnormality of macrophages (HP:0004311)3.10045410
35Myositis (HP:0100614)3.09846293
36Meningitis (HP:0001287)3.05171606
37Abnormality of the prostate (HP:0008775)3.01972251
38Visual hallucinations (HP:0002367)2.93681073
39Exercise intolerance (HP:0003546)2.92249899
40Abnormality of aromatic amino acid family metabolism (HP:0004338)2.92233078
41Eczematoid dermatitis (HP:0000976)2.87189894
42Febrile seizures (HP:0002373)2.84845598
43Vasculitis (HP:0002633)2.84250800
44Abnormality of cells of the erythroid lineage (HP:0012130)2.83697341
453-Methylglutaconic aciduria (HP:0003535)2.83302997
46Retrobulbar optic neuritis (HP:0100654)2.81406628
47Optic neuritis (HP:0100653)2.81406628
48Increased serum lactate (HP:0002151)2.75746418
49Chronic otitis media (HP:0000389)2.72733859
50Generalized aminoaciduria (HP:0002909)2.70761370
51Focal seizures (HP:0007359)2.68732368
52Orchitis (HP:0100796)2.67923132
53Petechiae (HP:0000967)2.67266523
54Recurrent skin infections (HP:0001581)2.66398973
55Abnormal respiratory motile cilium physiology (HP:0012261)2.66137781
56Abnormal ciliary motility (HP:0012262)2.65856350
57Abnormal delayed hypersensitivity skin test (HP:0002963)2.63902519
58Abnormal respiratory epithelium morphology (HP:0012253)2.61336262
59Abnormal respiratory motile cilium morphology (HP:0005938)2.61336262
60Pulmonary infiltrates (HP:0002113)2.58638925
61Mediastinal lymphadenopathy (HP:0100721)2.58116256
62Chronic sinusitis (HP:0011109)2.57893682
63Recurrent gram-negative bacterial infections (HP:0005420)2.57513353
64Dialeptic seizures (HP:0011146)2.55135582
65Optic disc pallor (HP:0000543)2.55000187
66Abnormal number of erythroid precursors (HP:0012131)2.54507772
67Increased IgM level (HP:0003496)2.53405524
68Medial flaring of the eyebrow (HP:0010747)2.51707722
69Respiratory failure (HP:0002878)2.49806316
70Abnormality of renal resorption (HP:0011038)2.48323275
71Recurrent fungal infections (HP:0002841)2.48140231
72Leukodystrophy (HP:0002415)2.46134179
73Encephalitis (HP:0002383)2.45304233
74Exertional dyspnea (HP:0002875)2.44675558
75Respiratory difficulties (HP:0002880)2.40994331
76Absence seizures (HP:0002121)2.40701279
77Epileptic encephalopathy (HP:0200134)2.39975995
78Neuroendocrine neoplasm (HP:0100634)2.39544838
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.39385951
80Prolonged partial thromboplastin time (HP:0003645)2.36052365
81Spastic paraparesis (HP:0002313)2.33352794
82Urticaria (HP:0001025)2.33093851
83Hemoptysis (HP:0002105)2.31341338
84Emotional lability (HP:0000712)2.29990155
85Recurrent sinusitis (HP:0011108)2.28630761
86Abnormal gallbladder physiology (HP:0012438)2.28024289
87Cholecystitis (HP:0001082)2.28024289
88Agammaglobulinemia (HP:0004432)2.27581458
89Pheochromocytoma (HP:0002666)2.25982827
90Congenital primary aphakia (HP:0007707)2.25894363
91Gait imbalance (HP:0002141)2.25603571
92Autoimmune hemolytic anemia (HP:0001890)2.24016337
93Lethargy (HP:0001254)2.21894771
94Progressive cerebellar ataxia (HP:0002073)2.21364856
95Scanning speech (HP:0002168)2.20419058
96Panhypogammaglobulinemia (HP:0003139)2.19595470
97Abnormality of T cell number (HP:0011839)2.18794891
98Abnormality of the pleura (HP:0002103)2.18219412
99Hypoglycemic seizures (HP:0002173)2.17327931
100Hyperventilation (HP:0002883)2.16907185
101Recurrent cutaneous fungal infections (HP:0011370)2.16389288
102Chronic mucocutaneous candidiasis (HP:0002728)2.16389288
103Prolonged bleeding time (HP:0003010)2.15841947
104Abnormality of T cells (HP:0002843)2.15706920
105Abnormality of the heme biosynthetic pathway (HP:0010472)2.15226581
106Male infertility (HP:0003251)2.14860086
107Progressive inability to walk (HP:0002505)2.14650227
108Abnormality of the nasal mucosa (HP:0000433)2.14180529
109Gastrointestinal infarctions (HP:0005244)2.12776604
110Generalized tonic-clonic seizures (HP:0002069)2.12153948
111Recurrent bronchitis (HP:0002837)2.11986387
112Progressive muscle weakness (HP:0003323)2.11885260
113Autoimmune thrombocytopenia (HP:0001973)2.11602416
114Stomach cancer (HP:0012126)2.11483975
115Alveolar cell carcinoma (HP:0006519)2.08812294
116T lymphocytopenia (HP:0005403)2.08571328
117Esotropia (HP:0000565)2.08445691
118Epistaxis (HP:0000421)2.08194391
119Infertility (HP:0000789)2.07941352
120Nephrogenic diabetes insipidus (HP:0009806)2.07914728
121Gaze-evoked nystagmus (HP:0000640)2.07085170
122Poor suck (HP:0002033)2.07001575
123Gangrene (HP:0100758)2.06767127
124Abnormality of liposaccharide metabolism (HP:0010968)2.06500951
125Abnormality of glycosphingolipid metabolism (HP:0004343)2.06500951
126Abnormality of glycolipid metabolism (HP:0010969)2.06500951
127Mutism (HP:0002300)2.06385919
128Pulmonary fibrosis (HP:0002206)2.06100396
129Hypobetalipoproteinemia (HP:0003563)2.05741885
130Delusions (HP:0000746)2.05006954
131Absent rod-and cone-mediated responses on ERG (HP:0007688)2.02630008
132Skin rash (HP:0000988)2.02446392
133Tetany (HP:0001281)2.01653940
134Abnormality of T cell physiology (HP:0011840)2.01526204
135Pulmonary embolism (HP:0002204)2.01417804
136Hypercortisolism (HP:0001578)2.00320761
137Chest pain (HP:0100749)1.99101009
138Polyneuropathy (HP:0001271)1.97814053
139Abnormal rod and cone electroretinograms (HP:0008323)1.97787192
140Bronchiectasis (HP:0002110)1.97527350
141Hypochromic microcytic anemia (HP:0004840)1.97385643
142Systemic lupus erythematosus (HP:0002725)1.96504167
143Abnormality of B cell number (HP:0010975)1.95343596
144Purpura (HP:0000979)1.94979961
145Pancreatic fibrosis (HP:0100732)1.93943572
146Hyperphosphaturia (HP:0003109)1.92084316
147Keratoconjunctivitis sicca (HP:0001097)1.91423870
148Vacuolated lymphocytes (HP:0001922)1.91078175
149Ketoacidosis (HP:0001993)1.90676180
150CNS demyelination (HP:0007305)1.90050597
151Poor coordination (HP:0002370)1.88739631
152Anorexia (HP:0002039)1.88551221
153Nasal polyposis (HP:0100582)1.87676278
154CNS hypomyelination (HP:0003429)1.86480731
155Rhinitis (HP:0012384)1.84970326
156Progressive external ophthalmoplegia (HP:0000590)1.84889493
157Postural tremor (HP:0002174)1.83742980
158Nonprogressive disorder (HP:0003680)1.81642981
159Decreased muscle mass (HP:0003199)1.81038273
160Cerebral hemorrhage (HP:0001342)1.79518964
161Inability to walk (HP:0002540)1.79312971
162Anxiety (HP:0000739)1.77041525
163Hypokinesia (HP:0002375)1.76412537
164Reduced antithrombin III activity (HP:0001976)1.76092204
165Palpitations (HP:0001962)1.75913126
166Glycosuria (HP:0003076)1.73410711
167Abnormality of urine glucose concentration (HP:0011016)1.73410711
168X-linked dominant inheritance (HP:0001423)1.72801952
169Genital tract atresia (HP:0001827)1.72078711
170Bradykinesia (HP:0002067)1.70056775
171Upper motor neuron abnormality (HP:0002127)1.69427665
172Neoplasm of head and neck (HP:0012288)1.68683167

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K125.37553730
2MUSK4.06313442
3MAP2K73.05574585
4CASK2.67281707
5CDK192.55530835
6MST42.49232321
7GRK52.45295209
8MAP3K42.41034658
9NTRK32.29813282
10ARAF2.27969485
11NME22.20210517
12MAP2K42.07410178
13IKBKE2.07024224
14PDK42.06549031
15PDK32.06549031
16NME12.06314203
17MAP3K92.04373151
18RIPK42.01504343
19BLK1.92966339
20IKBKB1.89974597
21TLK11.87684224
22MAP4K21.86465397
23MAPKAPK51.79584308
24IRAK41.72820756
25CCNB11.72058826
26CSF1R1.71718381
27KDR1.67027567
28ADRBK21.60679790
29PINK11.58775783
30TYK21.57518234
31MINK11.56476100
32TBK11.54592276
33NUAK11.53963824
34ZAK1.53205951
35CSK1.52178518
36LYN1.47347818
37MYLK1.45454965
38PNCK1.42214812
39MAP3K141.39523337
40STK161.37713317
41ZAP701.36494431
42ITK1.31816228
43DAPK11.26362349
44VRK21.25923821
45AKT31.25827146
46MST1R1.25589954
47SYK1.24744228
48BRAF1.23924862
49PLK21.23882957
50MAP3K131.22951941
51FES1.22545978
52TESK21.20913213
53EPHA41.17248722
54KSR21.16083689
55GRK71.15318677
56DAPK21.13772003
57PRKCQ1.09769390
58CSNK1G31.08758981
59MAP2K31.08675080
60CAMKK21.08485731
61EIF2AK31.07628550
62HCK1.06918867
63LCK0.99381033
64MAPK130.98771949
65PDK10.96190537
66TNIK0.94111802
67MARK30.92793697
68CSNK1G20.92694186
69GRK60.92148594
70FLT30.90134202
71MAPKAPK30.90042878
72JAK20.87918074
73PDK20.85555480
74MAP3K30.85268278
75PIK3CG0.83540409
76MAP2K60.82148286
77INSRR0.82130034
78TAOK20.82007052
79BMPR20.77489114
80PRKCG0.75932850
81JAK30.75716359
82PIM10.75503776
83CAMK2A0.75495433
84RPS6KB10.75415040
85PDPK10.74928051
86OXSR10.74764747
87KIT0.73991891
88ERBB40.73454406
89STK390.69761537
90CSNK1G10.69745426
91TAOK30.68526801
92MAP4K10.68245207
93BCKDK0.66371680
94TEC0.65324645
95TSSK60.64263209
96MAP3K110.64189728
97SIK30.63719014
98ACVR1B0.63640712
99PLK40.63472939
100FRK0.62780282
101RAF10.61726445
102NTRK10.60810466
103TNK20.60628885
104CAMK10.59359477
105PTK2B0.59116330
106WNK40.57219289
107MAP3K10.56853345
108BTK0.56722790
109TESK10.54763742
110MAPK40.54473493
111ADRBK10.53727502
112VRK10.53573150
113TAOK10.52985779
114SGK20.52748441
115MAPK150.52477537
116HIPK20.52018204
117CAMK2B0.51063898
118CAMK2G0.50995720
119PRKG20.50908429
120NTRK20.50862222
121BUB10.50630431
122MATK0.49923066
123JAK10.49237829
124KSR10.49214496
125ABL20.49126924
126ERN10.46853868
127MAP3K60.46528224
128LMTK20.46527812
129RPS6KA50.45893373
130CDK50.45016574
131ABL10.44804415
132LRRK20.44392980
133MOS0.43903875
134STK40.42647572
135PRKCD0.40709217
136BMPR1B0.40496107
137SCYL20.40486003
138GRK10.39889203
139PRKACA0.39874092
140IGF1R0.38623429
141CSNK1A1L0.38401033
142CAMK2D0.38241290
143STK110.37565407
144SGK4940.37222029
145SGK2230.37222029
146MAPK120.36955593
147ERBB30.36106066
148FGR0.36012052
149FYN0.34895944
150TXK0.34677246
151MAP3K50.34542371
152STK100.34388911
153PIM20.33214819
154IRAK10.32376941

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.87913636
2Parkinsons disease_Homo sapiens_hsa050124.25527708
3Allograft rejection_Homo sapiens_hsa053304.12292970
4Autoimmune thyroid disease_Homo sapiens_hsa053204.01561790
5Asthma_Homo sapiens_hsa053103.97060912
6Graft-versus-host disease_Homo sapiens_hsa053323.90822061
7Type I diabetes mellitus_Homo sapiens_hsa049403.45186368
8Alzheimers disease_Homo sapiens_hsa050103.16579806
9Intestinal immune network for IgA production_Homo sapiens_hsa046723.11219025
10Staphylococcus aureus infection_Homo sapiens_hsa051502.93871528
11Huntingtons disease_Homo sapiens_hsa050162.91520547
12Antigen processing and presentation_Homo sapiens_hsa046122.69597748
13Collecting duct acid secretion_Homo sapiens_hsa049662.66927429
14Leishmaniasis_Homo sapiens_hsa051402.52915947
15Synaptic vesicle cycle_Homo sapiens_hsa047212.51904546
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.42697328
17Pyruvate metabolism_Homo sapiens_hsa006202.38989404
18Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.28189129
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.26131044
20Primary immunodeficiency_Homo sapiens_hsa053402.24641835
21Nicotine addiction_Homo sapiens_hsa050332.17181724
22Ribosome_Homo sapiens_hsa030102.09333535
23Proteasome_Homo sapiens_hsa030502.03146420
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.97965281
25Cardiac muscle contraction_Homo sapiens_hsa042601.80432488
26Hematopoietic cell lineage_Homo sapiens_hsa046401.80317436
27RNA polymerase_Homo sapiens_hsa030201.78300493
28Viral myocarditis_Homo sapiens_hsa054161.76448299
29Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.76366267
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.69778551
31Taste transduction_Homo sapiens_hsa047421.69589443
32Propanoate metabolism_Homo sapiens_hsa006401.69430458
33Olfactory transduction_Homo sapiens_hsa047401.59845850
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.53103370
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.51395791
36Vitamin B6 metabolism_Homo sapiens_hsa007501.49952440
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45491224
38Tuberculosis_Homo sapiens_hsa051521.43810679
39Vibrio cholerae infection_Homo sapiens_hsa051101.42602110
40Long-term potentiation_Homo sapiens_hsa047201.41738523
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.35802336
42Amphetamine addiction_Homo sapiens_hsa050311.31005029
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.30327884
44Fatty acid elongation_Homo sapiens_hsa000621.30128081
45Osteoclast differentiation_Homo sapiens_hsa043801.30119340
46Herpes simplex infection_Homo sapiens_hsa051681.26126085
47Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.24233570
48GABAergic synapse_Homo sapiens_hsa047271.22686066
49Folate biosynthesis_Homo sapiens_hsa007901.21800059
50Caffeine metabolism_Homo sapiens_hsa002321.20461734
51NOD-like receptor signaling pathway_Homo sapiens_hsa046211.16039201
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14458152
53Circadian entrainment_Homo sapiens_hsa047131.11685849
54Serotonergic synapse_Homo sapiens_hsa047261.10887486
55Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08557570
56Morphine addiction_Homo sapiens_hsa050321.07747313
57Phagosome_Homo sapiens_hsa041451.06559202
58Sulfur metabolism_Homo sapiens_hsa009201.06326669
59Glutamatergic synapse_Homo sapiens_hsa047241.06265564
60Butanoate metabolism_Homo sapiens_hsa006501.05893769
61Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05712167
62Dopaminergic synapse_Homo sapiens_hsa047281.05272600
63Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04068243
64Salivary secretion_Homo sapiens_hsa049701.02928698
65Cysteine and methionine metabolism_Homo sapiens_hsa002701.01298679
66NF-kappa B signaling pathway_Homo sapiens_hsa040641.00299085
67Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99213152
68Systemic lupus erythematosus_Homo sapiens_hsa053220.98738617
69Protein export_Homo sapiens_hsa030600.98019683
70Fatty acid degradation_Homo sapiens_hsa000710.96217301
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96098174
72Influenza A_Homo sapiens_hsa051640.94893001
73Legionellosis_Homo sapiens_hsa051340.93996410
74Carbon metabolism_Homo sapiens_hsa012000.92400371
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.90134496
76Toxoplasmosis_Homo sapiens_hsa051450.87269675
77Insulin secretion_Homo sapiens_hsa049110.86406074
78Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85214304
79Calcium signaling pathway_Homo sapiens_hsa040200.84410301
80Measles_Homo sapiens_hsa051620.84360951
81Malaria_Homo sapiens_hsa051440.82535098
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81626440
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.81346019
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81299196
85Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79820795
86Maturity onset diabetes of the young_Homo sapiens_hsa049500.79721362
87Peroxisome_Homo sapiens_hsa041460.79516148
88Metabolic pathways_Homo sapiens_hsa011000.79459957
89B cell receptor signaling pathway_Homo sapiens_hsa046620.79439293
90Histidine metabolism_Homo sapiens_hsa003400.78751615
91Renin secretion_Homo sapiens_hsa049240.77975922
92Lysosome_Homo sapiens_hsa041420.77348986
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77021226
94Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.75478854
95Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75339302
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75329830
97Pertussis_Homo sapiens_hsa051330.73925599
98Purine metabolism_Homo sapiens_hsa002300.70927158
99T cell receptor signaling pathway_Homo sapiens_hsa046600.70446077
100Tyrosine metabolism_Homo sapiens_hsa003500.68947972
101Pyrimidine metabolism_Homo sapiens_hsa002400.68672868
102Fructose and mannose metabolism_Homo sapiens_hsa000510.68126640
103Rheumatoid arthritis_Homo sapiens_hsa053230.67424618
104Epstein-Barr virus infection_Homo sapiens_hsa051690.66809906
105Gastric acid secretion_Homo sapiens_hsa049710.65581320
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.64916745
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64797864
108Long-term depression_Homo sapiens_hsa047300.64513950
109Homologous recombination_Homo sapiens_hsa034400.63887138
110Arachidonic acid metabolism_Homo sapiens_hsa005900.63804842
111Fatty acid metabolism_Homo sapiens_hsa012120.59764904
112Linoleic acid metabolism_Homo sapiens_hsa005910.58738213
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58710040
114Chemical carcinogenesis_Homo sapiens_hsa052040.56093294
115Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55947791
116Tryptophan metabolism_Homo sapiens_hsa003800.55234028
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54912405
118Sulfur relay system_Homo sapiens_hsa041220.54742356
119Arginine biosynthesis_Homo sapiens_hsa002200.54155597
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53794631
121Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53768050
122Phototransduction_Homo sapiens_hsa047440.53605377
123Chemokine signaling pathway_Homo sapiens_hsa040620.53419248
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53347396
125Glucagon signaling pathway_Homo sapiens_hsa049220.51275892
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50637902
127Oocyte meiosis_Homo sapiens_hsa041140.50026575
128Cholinergic synapse_Homo sapiens_hsa047250.49030294
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48415703
130Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47644859
131Cocaine addiction_Homo sapiens_hsa050300.46809088
132Shigellosis_Homo sapiens_hsa051310.46552457
133Salmonella infection_Homo sapiens_hsa051320.46228240
134Phenylalanine metabolism_Homo sapiens_hsa003600.46049118
135Jak-STAT signaling pathway_Homo sapiens_hsa046300.45627484
136Glutathione metabolism_Homo sapiens_hsa004800.45496654
137Mismatch repair_Homo sapiens_hsa034300.44596129
138Platelet activation_Homo sapiens_hsa046110.43483548
139Drug metabolism - other enzymes_Homo sapiens_hsa009830.43429799
140African trypanosomiasis_Homo sapiens_hsa051430.43032538
141Bile secretion_Homo sapiens_hsa049760.42974013
142Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41682030
143Regulation of autophagy_Homo sapiens_hsa041400.39109481
144Other glycan degradation_Homo sapiens_hsa005110.38733466
145alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36908389
146Phosphatidylinositol signaling system_Homo sapiens_hsa040700.33344550
1472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.32376181
148Oxytocin signaling pathway_Homo sapiens_hsa049210.31087403
149Glycerolipid metabolism_Homo sapiens_hsa005610.30204261
150Biosynthesis of amino acids_Homo sapiens_hsa012300.29974771
151GnRH signaling pathway_Homo sapiens_hsa049120.29346269
152ABC transporters_Homo sapiens_hsa020100.28833506
153Retinol metabolism_Homo sapiens_hsa008300.28824879
154Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.26317366
155Base excision repair_Homo sapiens_hsa034100.25204748
156Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.24474939
157TNF signaling pathway_Homo sapiens_hsa046680.24391066
158Glycosaminoglycan degradation_Homo sapiens_hsa005310.23746676
159Steroid hormone biosynthesis_Homo sapiens_hsa001400.21306626
160Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21009014
161Complement and coagulation cascades_Homo sapiens_hsa046100.18251286
162Glycerophospholipid metabolism_Homo sapiens_hsa005640.18149630
163RNA degradation_Homo sapiens_hsa030180.17599026

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