CCDC184

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.55971341
2pyrimidine nucleobase catabolic process (GO:0006208)5.27913508
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.15162827
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.11355591
5synaptic vesicle exocytosis (GO:0016079)5.06478760
6vocalization behavior (GO:0071625)5.01411006
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.98499214
8establishment of mitochondrion localization (GO:0051654)4.85705707
9layer formation in cerebral cortex (GO:0021819)4.52455589
10neuron recognition (GO:0008038)4.52312848
11protein localization to synapse (GO:0035418)4.50676778
12synaptic vesicle maturation (GO:0016188)4.42031000
13regulation of glutamate receptor signaling pathway (GO:1900449)4.39749127
14regulation of synaptic vesicle exocytosis (GO:2000300)4.39727328
15negative regulation of microtubule polymerization (GO:0031115)4.34000069
16glutamate secretion (GO:0014047)4.31730730
17dendritic spine morphogenesis (GO:0060997)4.27556400
18nucleobase catabolic process (GO:0046113)4.19666000
19neurotransmitter secretion (GO:0007269)4.07657674
20response to pheromone (GO:0019236)4.06818246
21establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.02207489
22mitochondrion transport along microtubule (GO:0047497)4.02207489
23behavioral response to nicotine (GO:0035095)4.01342883
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.00951327
25exploration behavior (GO:0035640)3.96163752
26axonal fasciculation (GO:0007413)3.91240408
27cell migration in hindbrain (GO:0021535)3.89458846
28locomotory exploration behavior (GO:0035641)3.81554713
29regulation of synaptic vesicle transport (GO:1902803)3.80109430
30ionotropic glutamate receptor signaling pathway (GO:0035235)3.76469595
31proline transport (GO:0015824)3.74381537
32regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.63931159
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.51085373
34dendrite morphogenesis (GO:0048813)3.50947639
35positive regulation of synapse assembly (GO:0051965)3.50058076
36positive regulation of synaptic transmission, GABAergic (GO:0032230)3.49203154
37glutamate receptor signaling pathway (GO:0007215)3.47598004
38regulation of neuronal synaptic plasticity (GO:0048168)3.47063010
39postsynaptic membrane organization (GO:0001941)3.44668860
40regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.43837452
41neurotransmitter transport (GO:0006836)3.40524928
42regulation of synapse structural plasticity (GO:0051823)3.39500264
43activation of protein kinase A activity (GO:0034199)3.38907178
44positive regulation of dendritic spine morphogenesis (GO:0061003)3.36956233
45neuromuscular synaptic transmission (GO:0007274)3.36809302
46neuronal action potential propagation (GO:0019227)3.36405259
47positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.34105717
48synaptic vesicle docking involved in exocytosis (GO:0016081)3.29666569
49regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.29243540
50synaptic transmission, glutamatergic (GO:0035249)3.25292034
51neuronal ion channel clustering (GO:0045161)3.25049465
52transmission of nerve impulse (GO:0019226)3.23524881
53neuron-neuron synaptic transmission (GO:0007270)3.18195729
54neurofilament cytoskeleton organization (GO:0060052)3.15593844
55auditory behavior (GO:0031223)3.15138048
56cerebellar Purkinje cell differentiation (GO:0021702)3.14825004
57synaptic vesicle endocytosis (GO:0048488)3.14415752
58regulation of vesicle fusion (GO:0031338)3.14367614
59regulation of neurotransmitter levels (GO:0001505)3.13046314
60cerebellar granule cell differentiation (GO:0021707)3.10223169
61synapse assembly (GO:0007416)3.09668990
62response to auditory stimulus (GO:0010996)3.05447230
63glycosphingolipid biosynthetic process (GO:0006688)3.04422512
64calcium ion-dependent exocytosis (GO:0017156)3.04009368
65regulation of cAMP-dependent protein kinase activity (GO:2000479)3.03805517
66dendrite development (GO:0016358)3.03200458
67startle response (GO:0001964)3.02755619
68positive regulation of dendritic spine development (GO:0060999)3.02416642
69negative regulation of synaptic transmission, GABAergic (GO:0032229)3.01781927
70mating behavior (GO:0007617)3.01630252
71dendritic spine organization (GO:0097061)3.01075996
72gamma-aminobutyric acid transport (GO:0015812)3.00859373
73presynaptic membrane assembly (GO:0097105)3.00752144
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.00140596
75axon extension (GO:0048675)2.99134707
76regulation of dendritic spine morphogenesis (GO:0061001)2.98115193
77adult walking behavior (GO:0007628)2.97743464
78adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.97225433
79central nervous system projection neuron axonogenesis (GO:0021952)2.96590170
80membrane hyperpolarization (GO:0060081)2.96314713
81regulation of postsynaptic membrane potential (GO:0060078)2.95984556
82cerebral cortex radially oriented cell migration (GO:0021799)2.94985508
83innervation (GO:0060384)2.92815830
84intraspecies interaction between organisms (GO:0051703)2.92811096
85social behavior (GO:0035176)2.92811096
86cellular potassium ion homeostasis (GO:0030007)2.91906874
87behavioral response to cocaine (GO:0048148)2.91308403
88regulation of excitatory postsynaptic membrane potential (GO:0060079)2.89964711
89regulation of respiratory system process (GO:0044065)2.88858650
90regulation of neurotransmitter secretion (GO:0046928)2.88780103
91G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.88427866
92neurotransmitter-gated ion channel clustering (GO:0072578)2.87921200
93establishment of synaptic vesicle localization (GO:0097480)2.87914581
94synaptic vesicle transport (GO:0048489)2.87914581
95retinal ganglion cell axon guidance (GO:0031290)2.87190625
96dopamine receptor signaling pathway (GO:0007212)2.86788743
97synaptic transmission, cholinergic (GO:0007271)2.85938199
98presynaptic membrane organization (GO:0097090)2.82962059
99organelle transport along microtubule (GO:0072384)2.82735773
100establishment of vesicle localization (GO:0051650)2.82662086
101prepulse inhibition (GO:0060134)2.81389442
102cerebellar Purkinje cell layer development (GO:0021680)2.81279895
103negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.80443169
104gamma-aminobutyric acid signaling pathway (GO:0007214)2.80287795
105regulation of synapse assembly (GO:0051963)2.80142980
106axon cargo transport (GO:0008088)2.79825615
107positive regulation of membrane potential (GO:0045838)2.78477233
108cerebellum development (GO:0021549)2.78222785
109long-term memory (GO:0007616)2.78183359
110protein polyglutamylation (GO:0018095)2.78104800
111synapse organization (GO:0050808)2.77862162
112membrane depolarization during action potential (GO:0086010)2.77079005
113positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.76791925
114clathrin coat assembly (GO:0048268)2.76680046
115regulation of synaptic transmission, glutamatergic (GO:0051966)2.75331785
116membrane depolarization (GO:0051899)2.75252488
117regulation of neurotransmitter transport (GO:0051588)2.74990286
118synaptic transmission (GO:0007268)2.74510833
119short-term memory (GO:0007614)2.74298469
120neuromuscular process controlling posture (GO:0050884)2.73975651
121response to histamine (GO:0034776)2.73276303
122positive regulation of synapse maturation (GO:0090129)2.73154351
123adult behavior (GO:0030534)2.72963096
124regulation of synaptic transmission, GABAergic (GO:0032228)2.72858233
125mechanosensory behavior (GO:0007638)2.72789114
126regulation of feeding behavior (GO:0060259)2.70744876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.74187791
2GBX2_23144817_ChIP-Seq_PC3_Human3.42360358
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97040867
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92838259
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.84127809
6REST_21632747_ChIP-Seq_MESCs_Mouse2.80626269
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77104975
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.75545837
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53346333
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50306756
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50306756
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.44268015
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43993715
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43982924
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.43055315
16SUZ12_27294783_Chip-Seq_ESCs_Mouse2.42332338
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38870767
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.35925007
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.35252486
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30835048
21TAF15_26573619_Chip-Seq_HEK293_Human2.25925121
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.24374979
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19228576
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.18641791
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.10812217
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.08789813
27ZNF274_21170338_ChIP-Seq_K562_Hela2.00457955
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.92227661
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.91220374
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.88290901
31IGF1R_20145208_ChIP-Seq_DFB_Human1.88087775
32RBPJ_22232070_ChIP-Seq_NCS_Mouse1.85890401
33DROSHA_22980978_ChIP-Seq_HELA_Human1.83221217
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.82954833
35RARB_27405468_Chip-Seq_BRAIN_Mouse1.82538033
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82490404
37RNF2_27304074_Chip-Seq_NSC_Mouse1.76602428
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68242047
39AR_21572438_ChIP-Seq_LNCaP_Human1.59189187
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.56291057
41SMAD4_21799915_ChIP-Seq_A2780_Human1.51792767
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51601341
43P300_19829295_ChIP-Seq_ESCs_Human1.51361834
44RING1B_27294783_Chip-Seq_ESCs_Mouse1.44766763
45MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.43322001
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40003771
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39116922
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38141549
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35567309
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30619436
51SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29853601
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.25610004
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.23790021
54GATA1_26923725_Chip-Seq_HPCs_Mouse1.23143842
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.22959274
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.22944630
57SOX2_21211035_ChIP-Seq_LN229_Gbm1.22821496
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22676955
59CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21874587
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19216843
61CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18659513
62RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18587385
63AR_25329375_ChIP-Seq_VCAP_Human1.17951046
64RING1B_27294783_Chip-Seq_NPCs_Mouse1.17281619
65STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16334245
66KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.16212941
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16027056
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14320156
69MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10075458
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.09644296
71VDR_22108803_ChIP-Seq_LS180_Human1.09175744
72P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08815912
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08711439
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08711439
75FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08279230
76UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06014736
77RUNX2_22187159_ChIP-Seq_PCA_Human1.05866089
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03396920
79STAT3_23295773_ChIP-Seq_U87_Human1.03165801
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02715742
81FUS_26573619_Chip-Seq_HEK293_Human1.01122148
82LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99580104
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99211722
84OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97555507
85NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97273585
86ER_23166858_ChIP-Seq_MCF-7_Human0.97254136
87AR_19668381_ChIP-Seq_PC3_Human0.96800406
88ARNT_22903824_ChIP-Seq_MCF-7_Human0.96052585
89TP53_20018659_ChIP-ChIP_R1E_Mouse0.95667116
90CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95034893
91ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.93820959
92DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93564012
93AHR_22903824_ChIP-Seq_MCF-7_Human0.93136792
94PRDM14_20953172_ChIP-Seq_ESCs_Human0.92803449
95SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92483182
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92290127
97MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92003892
98SMAD3_21741376_ChIP-Seq_ESCs_Human0.91876079
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91046152
100TCF4_23295773_ChIP-Seq_U87_Human0.91013680
101JUN_21703547_ChIP-Seq_K562_Human0.90989862
102GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90965146
103SOX9_26525672_Chip-Seq_HEART_Mouse0.89601928
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.88598428
105YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87963248
106ZNF217_24962896_ChIP-Seq_MCF-7_Human0.87478371
107CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.87222355
108RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.86941149
109STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86853639
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86635078
111BCAT_22108803_ChIP-Seq_LS180_Human0.86324740
112KDM2B_26808549_Chip-Seq_REH_Human0.86081158
113CTCF_27219007_Chip-Seq_Bcells_Human0.85809346
114CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.85136158
115NANOG_18555785_Chip-Seq_ESCs_Mouse0.84946963
116CBP_20019798_ChIP-Seq_JUKART_Human0.83771920

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.57054072
2MP0004859_abnormal_synaptic_plasticity4.40857818
3MP0003635_abnormal_synaptic_transmissio3.54039770
4MP0006276_abnormal_autonomic_nervous3.40623433
5MP0005423_abnormal_somatic_nervous3.40356906
6MP0004270_analgesia3.39016865
7MP0002063_abnormal_learning/memory/cond2.97958853
8MP0005645_abnormal_hypothalamus_physiol2.96713562
9MP0009745_abnormal_behavioral_response2.87263443
10MP0001968_abnormal_touch/_nociception2.74567588
11MP0002734_abnormal_mechanical_nocicepti2.70524014
12MP0001984_abnormal_olfaction2.68965492
13MP0002064_seizures2.62473304
14MP0002572_abnormal_emotion/affect_behav2.61762089
15MP0009046_muscle_twitch2.53565197
16MP0002735_abnormal_chemical_nociception2.50181160
17MP0003122_maternal_imprinting2.47450926
18MP0002184_abnormal_innervation2.46668559
19MP0000778_abnormal_nervous_system2.39830722
20MP0002272_abnormal_nervous_system2.29744060
21MP0002733_abnormal_thermal_nociception2.28151720
22MP0001440_abnormal_grooming_behavior2.23251953
23MP0001529_abnormal_vocalization2.21048650
24MP0001486_abnormal_startle_reflex2.19562169
25MP0002736_abnormal_nociception_after2.10386952
26MP0002557_abnormal_social/conspecific_i2.09255171
27MP0001970_abnormal_pain_threshold2.06261772
28MP0001501_abnormal_sleep_pattern1.95708879
29MP0002067_abnormal_sensory_capabilities1.93460248
30MP0002909_abnormal_adrenal_gland1.88591368
31MP0010386_abnormal_urinary_bladder1.80601289
32MP0004811_abnormal_neuron_physiology1.72595572
33MP0004924_abnormal_behavior1.72534312
34MP0005386_behavior/neurological_phenoty1.72534312
35MP0002638_abnormal_pupillary_reflex1.70094852
36MP0000955_abnormal_spinal_cord1.64779231
37MP0002822_catalepsy1.63811643
38MP0004142_abnormal_muscle_tone1.63268180
39MP0001502_abnormal_circadian_rhythm1.62479525
40MP0005646_abnormal_pituitary_gland1.58247989
41MP0002882_abnormal_neuron_morphology1.52086319
42MP0008877_abnormal_DNA_methylation1.48209087
43MP0001905_abnormal_dopamine_level1.48080982
44MP0005499_abnormal_olfactory_system1.45757167
45MP0005394_taste/olfaction_phenotype1.45757167
46MP0003787_abnormal_imprinting1.39947825
47MP0003329_amyloid_beta_deposits1.37411468
48MP0002066_abnormal_motor_capabilities/c1.34859398
49MP0008569_lethality_at_weaning1.32501428
50MP0001188_hyperpigmentation1.32409696
51MP0003879_abnormal_hair_cell1.29541047
52MP0000566_synostosis1.28492175
53MP0002152_abnormal_brain_morphology1.21490998
54MP0004858_abnormal_nervous_system1.21306017
55MP0000013_abnormal_adipose_tissue1.21209331
56MP0008789_abnormal_olfactory_epithelium1.20794110
57MP0004742_abnormal_vestibular_system1.15654714
58MP0009780_abnormal_chondrocyte_physiolo1.14334474
59MP0002837_dystrophic_cardiac_calcinosis1.13903980
60MP0000631_abnormal_neuroendocrine_gland1.09742981
61MP0003123_paternal_imprinting1.05972979
62MP0006292_abnormal_olfactory_placode1.05604730
63MP0002752_abnormal_somatic_nervous1.03080516
64MP0000751_myopathy1.02178355
65MP0000538_abnormal_urinary_bladder1.00816572
66MP0002751_abnormal_autonomic_nervous0.99576771
67MP0005410_abnormal_fertilization0.97211287
68MP0003121_genomic_imprinting0.97010530
69MP0002102_abnormal_ear_morphology0.96246754
70MP0001986_abnormal_taste_sensitivity0.95659410
71MP0003011_delayed_dark_adaptation0.94329170
72MP0002069_abnormal_eating/drinking_beha0.93968013
73MP0000049_abnormal_middle_ear0.93123840
74MP0006072_abnormal_retinal_apoptosis0.91877665
75MP0000569_abnormal_digit_pigmentation0.89572563
76MP0003938_abnormal_ear_development0.89124525
77MP0002876_abnormal_thyroid_physiology0.88057416
78MP0005535_abnormal_body_temperature0.86553409
79MP0001963_abnormal_hearing_physiology0.84905190
80MP0003861_abnormal_nervous_system0.84446141
81MP0004885_abnormal_endolymph0.83707799
82MP0005551_abnormal_eye_electrophysiolog0.82980287
83MP0002229_neurodegeneration0.82045598
84MP0004145_abnormal_muscle_electrophysio0.81764683
85MP0003633_abnormal_nervous_system0.81551485
86MP0003634_abnormal_glial_cell0.79728543
87MP0005253_abnormal_eye_physiology0.78662280
88MP0001177_atelectasis0.76630196
89MP0004085_abnormal_heartbeat0.75601210
90MP0005623_abnormal_meninges_morphology0.75204487
91MP0003137_abnormal_impulse_conducting0.71548352
92MP0003631_nervous_system_phenotype0.71234251
93MP0003632_abnormal_nervous_system0.71006862
94MP0005195_abnormal_posterior_eye0.69648706
95MP0003136_yellow_coat_color0.69232670
96MP0000026_abnormal_inner_ear0.68669543
97MP0003183_abnormal_peptide_metabolism0.68031974
98MP0002234_abnormal_pharynx_morphology0.65791418
99MP0003890_abnormal_embryonic-extraembry0.65781711
100MP0001299_abnormal_eye_distance/0.65135604
101MP0005084_abnormal_gallbladder_morpholo0.63875031
102MP0008961_abnormal_basal_metabolism0.62820576
103MP0001943_abnormal_respiration0.62677707
104MP0000537_abnormal_urethra_morphology0.62636895
105MP0003942_abnormal_urinary_system0.62403099
106MP0002081_perinatal_lethality0.62288552
107MP0002928_abnormal_bile_duct0.61961265
108MP0002653_abnormal_ependyma_morphology0.60815048
109MP0003119_abnormal_digestive_system0.60622427
110MP0001664_abnormal_digestion0.60002515
111MP0008872_abnormal_physiological_respon0.58602765
112MP0001485_abnormal_pinna_reflex0.57607983
113MP0004133_heterotaxia0.57306965
114MP0000534_abnormal_ureter_morphology0.56535130
115MP0002082_postnatal_lethality0.55240087
116MP0010770_preweaning_lethality0.55240087
117MP0003698_abnormal_male_reproductive0.54075623
118MP0005187_abnormal_penis_morphology0.53355674
119MP0003956_abnormal_body_size0.52813585
120MP0001348_abnormal_lacrimal_gland0.52663297
121MP0010769_abnormal_survival0.52346287

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.62715165
2Myokymia (HP:0002411)5.36332273
3Visual hallucinations (HP:0002367)4.88371026
4Focal seizures (HP:0007359)4.84881396
5Limb dystonia (HP:0002451)4.70531212
6Atonic seizures (HP:0010819)4.35666108
7Absence seizures (HP:0002121)3.92478033
8Polyphagia (HP:0002591)3.73514785
9Progressive cerebellar ataxia (HP:0002073)3.67917051
10Febrile seizures (HP:0002373)3.62959922
11Epileptic encephalopathy (HP:0200134)3.57283575
12Ankle clonus (HP:0011448)3.50353831
13Supranuclear gaze palsy (HP:0000605)3.43456034
14Mutism (HP:0002300)3.42583065
15Failure to thrive in infancy (HP:0001531)3.42122550
16Agitation (HP:0000713)3.41970767
17Dialeptic seizures (HP:0011146)3.37896407
18Pheochromocytoma (HP:0002666)3.23267160
19Gait imbalance (HP:0002141)3.13751650
20Generalized tonic-clonic seizures (HP:0002069)3.12403313
21Abnormal eating behavior (HP:0100738)3.02235500
22Amblyopia (HP:0000646)3.00831035
23Neuroendocrine neoplasm (HP:0100634)2.88373014
24Excessive salivation (HP:0003781)2.81865574
25Drooling (HP:0002307)2.81865574
26Poor suck (HP:0002033)2.80478888
27Aplasia/Hypoplasia of the brainstem (HP:0007362)2.75187776
28Hypoplasia of the brainstem (HP:0002365)2.75187776
29Progressive inability to walk (HP:0002505)2.72587648
30Broad-based gait (HP:0002136)2.69678055
31Amyotrophic lateral sclerosis (HP:0007354)2.63348264
32Medial flaring of the eyebrow (HP:0010747)2.62267714
33Anxiety (HP:0000739)2.60713311
34Hypoventilation (HP:0002791)2.53648607
35Truncal ataxia (HP:0002078)2.51216479
36Akinesia (HP:0002304)2.51193077
37Depression (HP:0000716)2.51183455
38Spastic tetraplegia (HP:0002510)2.50021279
39Sleep apnea (HP:0010535)2.49619747
40EEG with generalized epileptiform discharges (HP:0011198)2.49031167
41Abnormal hair whorl (HP:0010721)2.48713839
42Nephronophthisis (HP:0000090)2.48399837
43Lissencephaly (HP:0001339)2.47838492
44Epileptiform EEG discharges (HP:0011182)2.46497276
45Abnormality of the labia minora (HP:0012880)2.46242102
46Retinal dysplasia (HP:0007973)2.46158951
47Specific learning disability (HP:0001328)2.44618499
48Urinary urgency (HP:0000012)2.44052486
49Absent/shortened dynein arms (HP:0200106)2.42654861
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.42654861
51Hemiparesis (HP:0001269)2.41415213
52Hypsarrhythmia (HP:0002521)2.41284651
53Pachygyria (HP:0001302)2.40128022
54Action tremor (HP:0002345)2.37334137
55Congenital primary aphakia (HP:0007707)2.35603169
56Impaired vibration sensation in the lower limbs (HP:0002166)2.35147438
57Hypothermia (HP:0002045)2.33350581
58Spastic gait (HP:0002064)2.32332324
59Hyperventilation (HP:0002883)2.30671753
60Esotropia (HP:0000565)2.29972665
61Abnormality of the corticospinal tract (HP:0002492)2.29234915
62Torticollis (HP:0000473)2.27881603
63Genetic anticipation (HP:0003743)2.27438732
64Cortical dysplasia (HP:0002539)2.26595372
65Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.22129917
66Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.21376643
67Urinary bladder sphincter dysfunction (HP:0002839)2.20578552
68Rhinitis (HP:0012384)2.19995626
69Nephrogenic diabetes insipidus (HP:0009806)2.19298444
70Status epilepticus (HP:0002133)2.18605795
71Ulnar claw (HP:0001178)2.18043558
72Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.16938975
73Degeneration of the lateral corticospinal tracts (HP:0002314)2.16938975
74Focal dystonia (HP:0004373)2.15976318
75Abnormality of the lower motor neuron (HP:0002366)2.15138234
76Acute necrotizing encephalopathy (HP:0006965)2.13945496
77Abnormal respiratory motile cilium physiology (HP:0012261)2.11008599
78Shoulder girdle muscle weakness (HP:0003547)2.08471832
79Cerebral inclusion bodies (HP:0100314)2.08381587
80Hyperthyroidism (HP:0000836)2.08110327
81Split foot (HP:0001839)2.06550479
82Abnormal respiratory epithelium morphology (HP:0012253)2.06421750
83Abnormal respiratory motile cilium morphology (HP:0005938)2.06421750
84Craniofacial dystonia (HP:0012179)2.05267474
85Diplopia (HP:0000651)2.04921117
86Abnormality of binocular vision (HP:0011514)2.04921117
87Insidious onset (HP:0003587)2.04121641
88Termporal pattern (HP:0011008)2.04121641
89Papilledema (HP:0001085)2.03423513
90Fetal akinesia sequence (HP:0001989)2.02934100
91Poor eye contact (HP:0000817)2.02811625
92Neurofibrillary tangles (HP:0002185)2.02177044
93Psychosis (HP:0000709)2.00465509
94Optic nerve hypoplasia (HP:0000609)1.99561034
95Genital tract atresia (HP:0001827)1.97594221
96Abnormal ciliary motility (HP:0012262)1.97499570
97Abnormality of salivation (HP:0100755)1.97384363
98Narrow nasal bridge (HP:0000446)1.96910005
99Anosmia (HP:0000458)1.96893240
100Abnormality of midbrain morphology (HP:0002418)1.95677997
101Molar tooth sign on MRI (HP:0002419)1.95677997
102Progressive macrocephaly (HP:0004481)1.95314343
103Abnormal mitochondria in muscle tissue (HP:0008316)1.94641821
104Abnormality of calcium-phosphate metabolism (HP:0100530)1.94264058
105Postural instability (HP:0002172)1.94185731
106Lower limb muscle weakness (HP:0007340)1.93877053
107Vaginal atresia (HP:0000148)1.93256095
108Morphological abnormality of the pyramidal tract (HP:0002062)1.93108817
109Absent speech (HP:0001344)1.92756400
110Pancreatic fibrosis (HP:0100732)1.92338913
111Protruding tongue (HP:0010808)1.91497838
112Exotropia (HP:0000577)1.90772218
113Apathy (HP:0000741)1.90313218
114True hermaphroditism (HP:0010459)1.89248507
115Oligomenorrhea (HP:0000876)1.88657328
116Bradykinesia (HP:0002067)1.88175195
117Type II lissencephaly (HP:0007260)1.86985898
118Hypoplasia of the corpus callosum (HP:0002079)1.85655798
119Abnormal social behavior (HP:0012433)1.85431941
120Impaired social interactions (HP:0000735)1.85431941
121Abnormality of the renal medulla (HP:0100957)1.81072477
122Hemiplegia (HP:0002301)1.78920674
123Inability to walk (HP:0002540)1.78917254
124Hepatoblastoma (HP:0002884)1.76522127
125Oligodactyly (hands) (HP:0001180)1.72566635
126Chronic hepatic failure (HP:0100626)1.72552761
127Intention tremor (HP:0002080)1.72039193
128Dysmetria (HP:0001310)1.70730398
129Pancreatic cysts (HP:0001737)1.70341304
130Generalized myoclonic seizures (HP:0002123)1.67929030
131Poor coordination (HP:0002370)1.66981844
132Incomplete penetrance (HP:0003829)1.66717416

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.33506829
2NTRK33.37309442
3MAP3K43.10399674
4NTRK23.02256549
5MAP3K123.02003015
6MAP2K72.92583438
7MINK12.91275638
8MAP3K92.79053469
9MAPK132.61257696
10PNCK2.39746936
11CASK2.31693680
12WNK32.24844547
13MAP4K21.98659707
14DYRK21.94171105
15MAP2K41.93349798
16SIK21.90834608
17PHKG21.88305084
18PHKG11.88305084
19UHMK11.85748293
20SIK31.76747588
21PINK11.74688060
22KSR11.60115643
23DAPK21.57814790
24GRK51.44031744
25EPHA41.43211757
26TRIM281.41973977
27PAK61.40847659
28MAPK151.38978517
29CDK51.35407774
30ERBB31.31130924
31TNIK1.28366858
32PAK31.26177006
33LIMK11.18590212
34PLK21.11357167
35EPHA31.10553293
36PRKD31.08508596
37PRKCG1.06910298
38CSNK1G21.06793398
39KSR21.03917137
40BCR1.03439424
41NTRK11.01292535
42DAPK10.95071797
43DYRK1A0.94868609
44CAMK2A0.92908593
45NME10.92276338
46BMPR1B0.92032575
47ARAF0.91742596
48TYRO30.88270487
49CDK180.87149876
50CDK190.87136843
51DYRK1B0.85976227
52CAMK2B0.84518140
53CDK140.83582512
54WNK40.81963466
55RIPK40.81110136
56MARK20.80549631
57CSNK1G30.80431950
58CDK150.78768694
59LATS20.78728597
60RPS6KA20.77598865
61GRK70.74903184
62FES0.72988732
63CAMKK10.72586508
64DYRK30.72413583
65CDK11A0.71709031
66PRKCZ0.68628013
67STK110.65314294
68PRKCE0.61630293
69SGK2230.61272161
70SGK4940.61272161
71FER0.61057266
72MAP3K20.60124217
73RET0.58901174
74STK390.56651136
75PRKCH0.55832095
76PKN10.55623476
77TESK10.55208738
78CAMK2D0.55006028
79ADRBK10.52765387
80MAPK120.52459417
81ADRBK20.50593607
82CAMK2G0.49828547
83CSNK1A1L0.46938828
84CAMK40.46767103
85CCNB10.46732863
86INSRR0.44226572
87CAMK1G0.44191079
88PRKG10.43827990
89CAMKK20.43125826
90BMPR20.42701622
91CSNK1E0.42422009
92CSNK1D0.41965954
93EPHB20.40213987
94CDC42BPA0.39291281
95MAPK90.38678348
96MAPKAPK50.38557335
97LMTK20.38282139
98CSNK1A10.36667481
99MAP3K110.34717365
100MAP3K60.34238658
101CSNK1G10.34018687
102BCKDK0.33663325
103ERBB20.32930749
104SGK10.32428528
105PRKACB0.32172881
106PRKAA10.32006434
107MAPK100.30937384
108OXSR10.30885084
109FYN0.30791879
110RPS6KA30.30732370
111PRKACA0.30179977
112STK380.29997752
113FGFR20.29661874
114PTK2B0.28986468
115SGK20.28650610
116CAMK10.28626467
117BRSK10.28421395
118PRKCB0.28063371
119MAPK40.28036685
120MAP2K10.27613216
121MAPK80.27583532
122RPS6KB10.26912318
123ICK0.26613117

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.57116523
2Synaptic vesicle cycle_Homo sapiens_hsa047213.47215882
3Olfactory transduction_Homo sapiens_hsa047402.93385403
4GABAergic synapse_Homo sapiens_hsa047272.58381283
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.42871830
6Amphetamine addiction_Homo sapiens_hsa050312.34729354
7Circadian entrainment_Homo sapiens_hsa047132.29110891
8Dopaminergic synapse_Homo sapiens_hsa047282.26452857
9Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.23400175
10Glutamatergic synapse_Homo sapiens_hsa047242.20779923
11Morphine addiction_Homo sapiens_hsa050322.19864121
12Cocaine addiction_Homo sapiens_hsa050302.17428157
13Insulin secretion_Homo sapiens_hsa049112.16044710
14Long-term potentiation_Homo sapiens_hsa047202.11194365
15Collecting duct acid secretion_Homo sapiens_hsa049662.00709321
16Taste transduction_Homo sapiens_hsa047421.99983875
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.99076733
18Oxidative phosphorylation_Homo sapiens_hsa001901.92784265
19Serotonergic synapse_Homo sapiens_hsa047261.91931958
20Cholinergic synapse_Homo sapiens_hsa047251.84336404
21Parkinsons disease_Homo sapiens_hsa050121.72516831
22Vibrio cholerae infection_Homo sapiens_hsa051101.64012385
23Cardiac muscle contraction_Homo sapiens_hsa042601.61772681
24Salivary secretion_Homo sapiens_hsa049701.55852490
25Renin secretion_Homo sapiens_hsa049241.53954622
26Axon guidance_Homo sapiens_hsa043601.52333972
27Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52329906
28Alzheimers disease_Homo sapiens_hsa050101.50957952
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48558098
30Long-term depression_Homo sapiens_hsa047301.46479890
31Gastric acid secretion_Homo sapiens_hsa049711.46197062
32Gap junction_Homo sapiens_hsa045401.42005308
33Oxytocin signaling pathway_Homo sapiens_hsa049211.34096278
34GnRH signaling pathway_Homo sapiens_hsa049121.29018220
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21356938
36Huntingtons disease_Homo sapiens_hsa050161.20976163
37Calcium signaling pathway_Homo sapiens_hsa040201.20423598
38Estrogen signaling pathway_Homo sapiens_hsa049151.17243968
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15142239
40Phototransduction_Homo sapiens_hsa047441.14568043
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10829757
42Steroid biosynthesis_Homo sapiens_hsa001001.06475092
43Type II diabetes mellitus_Homo sapiens_hsa049300.99833244
44cAMP signaling pathway_Homo sapiens_hsa040240.97616299
45ErbB signaling pathway_Homo sapiens_hsa040120.97257547
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97023497
47Melanogenesis_Homo sapiens_hsa049160.86543938
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.86041072
49Alcoholism_Homo sapiens_hsa050340.83484704
50Glioma_Homo sapiens_hsa052140.82554942
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.82030178
52Hedgehog signaling pathway_Homo sapiens_hsa043400.81241351
53Oocyte meiosis_Homo sapiens_hsa041140.80569227
54Protein export_Homo sapiens_hsa030600.74791430
55Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.74666980
56MAPK signaling pathway_Homo sapiens_hsa040100.73576988
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73462089
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.72123382
59cGMP-PKG signaling pathway_Homo sapiens_hsa040220.71475133
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71328715
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.70696099
62Prion diseases_Homo sapiens_hsa050200.69511131
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.68976322
64Type I diabetes mellitus_Homo sapiens_hsa049400.68262465
65Dorso-ventral axis formation_Homo sapiens_hsa043200.67727332
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.66330466
67Glucagon signaling pathway_Homo sapiens_hsa049220.63866809
68Hippo signaling pathway_Homo sapiens_hsa043900.63606317
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63288137
70Thyroid hormone synthesis_Homo sapiens_hsa049180.62413508
71Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61525018
72Basal cell carcinoma_Homo sapiens_hsa052170.59557730
73Dilated cardiomyopathy_Homo sapiens_hsa054140.59167167
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57590818
75Phagosome_Homo sapiens_hsa041450.55040854
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54533113
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.54065282
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53859060
79Ras signaling pathway_Homo sapiens_hsa040140.53694850
80Renal cell carcinoma_Homo sapiens_hsa052110.52282353
81Pancreatic secretion_Homo sapiens_hsa049720.51036481
82Rheumatoid arthritis_Homo sapiens_hsa053230.50822360
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50767663
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50052652
85Regulation of autophagy_Homo sapiens_hsa041400.49743894
86Choline metabolism in cancer_Homo sapiens_hsa052310.48820702
87Circadian rhythm_Homo sapiens_hsa047100.48654226
88Ether lipid metabolism_Homo sapiens_hsa005650.48521583
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.47759369
90Colorectal cancer_Homo sapiens_hsa052100.46239083
91Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.45718085
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44224686
93Insulin signaling pathway_Homo sapiens_hsa049100.42991881
94Endocytosis_Homo sapiens_hsa041440.42880066
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42283301
96Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42036946
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.41579310
98Wnt signaling pathway_Homo sapiens_hsa043100.41237261
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40830739
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40701670
101VEGF signaling pathway_Homo sapiens_hsa043700.40629375
102Endometrial cancer_Homo sapiens_hsa052130.39802276
103Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38300673
104Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37882922
105Ovarian steroidogenesis_Homo sapiens_hsa049130.36187457
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36091908
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.34874890
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.34466790
109Linoleic acid metabolism_Homo sapiens_hsa005910.33931688
110Bile secretion_Homo sapiens_hsa049760.33701754
111Nitrogen metabolism_Homo sapiens_hsa009100.33255028
112alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33049539
113Fatty acid biosynthesis_Homo sapiens_hsa000610.32783814
114Rap1 signaling pathway_Homo sapiens_hsa040150.31864848
115Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31340888
116Butanoate metabolism_Homo sapiens_hsa006500.28878490
117Prolactin signaling pathway_Homo sapiens_hsa049170.28610794
118Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.28553865
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.28291304
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.22529800

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