CCDC166

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)8.85197110
2proline metabolic process (GO:0006560)7.71761975
3transcription from mitochondrial promoter (GO:0006390)7.71415414
4replication fork processing (GO:0031297)7.27222456
5embryonic process involved in female pregnancy (GO:0060136)6.50290759
6positive regulation of protein homooligomerization (GO:0032464)6.32554807
7oxidative demethylation (GO:0070989)6.15640195
8maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.06844896
9mitochondrial DNA metabolic process (GO:0032042)5.22232595
10viral mRNA export from host cell nucleus (GO:0046784)5.18928344
11DNA strand renaturation (GO:0000733)5.16827300
12somatic diversification of immune receptors via somatic mutation (GO:0002566)5.16679559
13somatic hypermutation of immunoglobulin genes (GO:0016446)5.16679559
14regulation of protein homooligomerization (GO:0032462)5.07830357
15poly(A)+ mRNA export from nucleus (GO:0016973)5.04409596
16telomere maintenance via semi-conservative replication (GO:0032201)4.97110956
17negative regulation of JAK-STAT cascade (GO:0046426)4.85146443
18GDP-mannose metabolic process (GO:0019673)4.82858373
19establishment of apical/basal cell polarity (GO:0035089)4.78049187
20mRNA cleavage (GO:0006379)4.46213878
21nucleotide-excision repair, DNA gap filling (GO:0006297)4.40988260
22negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.40914758
23regulation of integrin activation (GO:0033623)4.38807506
24pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.30538639
25mitotic G1 DNA damage checkpoint (GO:0031571)4.28294869
26establishment or maintenance of monopolar cell polarity (GO:0061339)4.26249687
27establishment of monopolar cell polarity (GO:0061162)4.26249687
28base-excision repair (GO:0006284)4.25586427
29DNA ligation (GO:0006266)4.22377759
30negative regulation of cell cycle arrest (GO:0071157)4.16917288
31DNA strand elongation involved in DNA replication (GO:0006271)4.13124871
32non-recombinational repair (GO:0000726)4.11197015
33double-strand break repair via nonhomologous end joining (GO:0006303)4.11197015
34cellular response to ATP (GO:0071318)4.10807909
35negative regulation of mRNA processing (GO:0050686)4.07712284
36mitochondrial RNA metabolic process (GO:0000959)4.07481131
37cellular response to zinc ion (GO:0071294)4.05922490
38establishment of protein localization to mitochondrial membrane (GO:0090151)4.00934942
39formation of translation preinitiation complex (GO:0001731)3.96820729
40DNA strand elongation (GO:0022616)3.91153706
41telomere maintenance via recombination (GO:0000722)3.90722785
42base-excision repair, AP site formation (GO:0006285)3.88229519
43G1 DNA damage checkpoint (GO:0044783)3.84605605
44dosage compensation (GO:0007549)3.82936847
45termination of RNA polymerase II transcription (GO:0006369)3.82431459
46positive regulation of developmental pigmentation (GO:0048087)3.76968644
47mitotic G1/S transition checkpoint (GO:0044819)3.75045932
48glutamine family amino acid biosynthetic process (GO:0009084)3.71994343
49DNA integration (GO:0015074)3.68840349
50histone H4-K12 acetylation (GO:0043983)3.66610111
51positive regulation of DNA repair (GO:0045739)3.65620702
52pyrimidine nucleotide catabolic process (GO:0006244)3.64345087
53spliceosomal tri-snRNP complex assembly (GO:0000244)3.60249351
54negative regulation of RNA splicing (GO:0033119)3.58833342
55regulation of translational fidelity (GO:0006450)3.45865157
56DNA double-strand break processing (GO:0000729)3.45768982
57embryonic placenta development (GO:0001892)3.44341882
58DNA demethylation (GO:0080111)3.40914620
59mitotic nuclear envelope reassembly (GO:0007084)3.40567284
60nuclear envelope reassembly (GO:0031468)3.40567284
61positive regulation by host of viral transcription (GO:0043923)3.37391030
62positive regulation of protein oligomerization (GO:0032461)3.35461672
63negative regulation of mRNA metabolic process (GO:1903312)3.35321179
64mitochondrial DNA replication (GO:0006264)3.32742071
65telomere maintenance via telomere lengthening (GO:0010833)3.32046020
66DNA topological change (GO:0006265)3.28546109
67mitotic recombination (GO:0006312)3.26504695
68meiotic chromosome segregation (GO:0045132)3.22586387
69regulation of double-strand break repair via homologous recombination (GO:0010569)3.22472743
70cellular zinc ion homeostasis (GO:0006882)3.19195457
71maturation of 5.8S rRNA (GO:0000460)3.18657489
72pseudouridine synthesis (GO:0001522)3.17323468
73resolution of meiotic recombination intermediates (GO:0000712)3.16517942
74negative regulation of heart rate (GO:0010459)3.02176336
75convergent extension (GO:0060026)3.00994597
76single strand break repair (GO:0000012)3.00949153
77glycerol ether metabolic process (GO:0006662)3.00582170
78negative regulation of tumor necrosis factor production (GO:0032720)2.99041059
79mRNA polyadenylation (GO:0006378)2.96554737
80regulation of protein oligomerization (GO:0032459)2.94927646
81somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.92900195
82somatic cell DNA recombination (GO:0016444)2.92900195
83negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.89314600
84V(D)J recombination (GO:0033151)2.89250071
85regulation of cilium movement (GO:0003352)2.87489693
86negative regulation of protein oligomerization (GO:0032460)2.87370750
87negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.86530017
88epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.85393622
89pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.85141289
90regulation of DNA damage checkpoint (GO:2000001)2.84736526
91mRNA 3-end processing (GO:0031124)2.83878336
92protein retention in ER lumen (GO:0006621)2.83756374
93face development (GO:0060324)2.81936226
94mRNA export from nucleus (GO:0006406)2.80435681
95somatic diversification of immune receptors (GO:0002200)2.79063927
96RNA polyadenylation (GO:0043631)2.78917167
97protein deneddylation (GO:0000338)2.75234843
98regulation of mitochondrial depolarization (GO:0051900)2.74903060
99DNA dealkylation (GO:0035510)2.72392671
100proline biosynthetic process (GO:0006561)10.4996072

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse3.29107301
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.93804507
3VDR_21846776_ChIP-Seq_THP-1_Human2.80066204
4E2F7_22180533_ChIP-Seq_HELA_Human2.78584093
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.76480633
6MYC_18358816_ChIP-ChIP_MESCs_Mouse2.68846745
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.44554151
8HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32539903
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.24534689
10DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.23841988
11DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.14371045
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.12195419
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11350446
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.03363899
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.02778460
16YY1_21170310_ChIP-Seq_MESCs_Mouse2.01720620
17PU.1_20513432_ChIP-Seq_Bcells_Mouse1.95331033
18MYC_22102868_ChIP-Seq_BL_Human1.93828321
19TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.93689943
20E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89706053
21GABP_17652178_ChIP-ChIP_JURKAT_Human1.88012615
22GABP_19822575_ChIP-Seq_HepG2_Human1.84764817
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.80962634
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80143583
25LXR_22292898_ChIP-Seq_THP-1_Human1.77337520
26KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.75068648
27DCP1A_22483619_ChIP-Seq_HELA_Human1.72902029
28CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72342367
29NOTCH1_21737748_ChIP-Seq_TLL_Human1.69200742
30BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.65183018
31XRN2_22483619_ChIP-Seq_HELA_Human1.63068518
32KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.62669920
33KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.62669920
34KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.62669920
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.60606062
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.59265331
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.58416171
38TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56965623
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.56699694
40VDR_23849224_ChIP-Seq_CD4+_Human1.54778200
41PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.52808872
42TTF2_22483619_ChIP-Seq_HELA_Human1.52478522
43RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.51984541
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.51476470
45POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51029603
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.49813009
47FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.47485949
48ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47485137
49ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46162668
50SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.45566992
51STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38997862
52SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38961337
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.37703455
54NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35775063
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.35324200
56CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.34202084
57CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.34073290
58CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33986212
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33353066
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.32041733
61NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.31416949
62NANOG_21062744_ChIP-ChIP_HESCs_Human1.31004605
63KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30932431
64GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30870863
65POU5F1_16518401_ChIP-PET_MESCs_Mouse1.29444324
66RARB_24833708_ChIP-Seq_LIVER_Mouse1.28167558
67GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27735406
68SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26887051
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.25687645
70NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.25261370
71FOXP3_21729870_ChIP-Seq_TREG_Human1.25038777
72KDM5A_27292631_Chip-Seq_BREAST_Human1.24718314
73SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.23618627
74YY1_22570637_ChIP-Seq_MALME-3M_Human1.22728404
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22243646
76ETS1_21867929_ChIP-Seq_TH2_Mouse1.21788934
77MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21245752
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21170751
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19005451
80HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17893278
81VDR_24763502_ChIP-Seq_THP-1_Human1.17518520
82STAT1_20625510_ChIP-Seq_HELA_Human1.17262998
83POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.16543534
84TCF3_18692474_ChIP-Seq_MESCs_Mouse1.14643860
85CTCF_21964334_ChIP-Seq_BJAB-B_Human1.14306878
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.13390461
87CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11313027
88POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.10660124
89RXRA_24833708_ChIP-Seq_LIVER_Mouse1.10549413
90CTCF_26484167_Chip-Seq_Bcells_Mouse1.09585304
91MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09449467
92PHF8_20622854_ChIP-Seq_HELA_Human1.08956838
93POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08655736
94ERG_21242973_ChIP-ChIP_JURKAT_Human1.08022545
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07898284
96NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.06409940
97ELF1_20517297_ChIP-Seq_JURKAT_Human1.05230624
98KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04318338
99E2F4_17652178_ChIP-ChIP_JURKAT_Human1.04040243
100RARA_24833708_ChIP-Seq_LIVER_Mouse1.03565894

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.76601192
2MP0002009_preneoplasia4.47384390
3MP0009278_abnormal_bone_marrow3.62795988
4MP0005171_absent_coat_pigmentation3.29400671
5MP0008995_early_reproductive_senescence2.99084225
6MP0005174_abnormal_tail_pigmentation2.91701177
7MP0006072_abnormal_retinal_apoptosis2.82309588
8MP0010030_abnormal_orbit_morphology2.73542396
9MP0010094_abnormal_chromosome_stability2.54573427
10MP0004233_abnormal_muscle_weight2.48401939
11MP0005075_abnormal_melanosome_morpholog2.38780887
12MP0008058_abnormal_DNA_repair2.38142834
13MP0003890_abnormal_embryonic-extraembry2.35260540
14MP0003786_premature_aging2.33637159
15MP0001545_abnormal_hematopoietic_system2.27313413
16MP0005397_hematopoietic_system_phenotyp2.27313413
17MP0003283_abnormal_digestive_organ2.22717904
18MP0003172_abnormal_lysosome_physiology2.15348535
19MP0000685_abnormal_immune_system2.01828347
20MP0000490_abnormal_crypts_of2.00378215
21MP0004957_abnormal_blastocyst_morpholog1.94330229
22MP0004133_heterotaxia1.90143812
23MP0002653_abnormal_ependyma_morphology1.89364453
24MP0000015_abnormal_ear_pigmentation1.81117730
25MP0008877_abnormal_DNA_methylation1.80873840
26MP0002166_altered_tumor_susceptibility1.71879774
27MP0003693_abnormal_embryo_hatching1.69126625
28MP0003119_abnormal_digestive_system1.65781469
29MP0005645_abnormal_hypothalamus_physiol1.64554451
30MP0003763_abnormal_thymus_physiology1.56676707
31MP0002396_abnormal_hematopoietic_system1.50429233
32MP0005220_abnormal_exocrine_pancreas1.49624720
33MP0000470_abnormal_stomach_morphology1.46980702
34MP0008932_abnormal_embryonic_tissue1.39866522
35MP0000371_diluted_coat_color1.38979426
36MP0005058_abnormal_lysosome_morphology1.38414040
37MP0003111_abnormal_nucleus_morphology1.38101814
38MP0000462_abnormal_digestive_system1.33177455
39MP0002006_tumorigenesis1.26940186
40MP0005365_abnormal_bile_salt1.24993564
41MP0000639_abnormal_adrenal_gland1.24772350
42MP0002019_abnormal_tumor_incidence1.21103085
43MP0005379_endocrine/exocrine_gland_phen1.20239642
44MP0001293_anophthalmia1.18662750
45MP0004264_abnormal_extraembryonic_tissu1.18100276
46MP0003077_abnormal_cell_cycle1.17320897
47MP0002163_abnormal_gland_morphology1.16232068
48MP0001697_abnormal_embryo_size1.14817971
49MP0006292_abnormal_olfactory_placode1.14716814
50MP0002084_abnormal_developmental_patter1.12826992
51MP0002249_abnormal_larynx_morphology1.12690605
52MP0009333_abnormal_splenocyte_physiolog1.10357683
53MP0002405_respiratory_system_inflammati1.09365574
54MP0000579_abnormal_nail_morphology1.08267966
55MP0002075_abnormal_coat/hair_pigmentati1.03831080
56MP0000313_abnormal_cell_death1.02145417
57MP0000350_abnormal_cell_proliferation1.02071003
58MP0005253_abnormal_eye_physiology1.01870039
59MP0002085_abnormal_embryonic_tissue0.98866097
60MP0001186_pigmentation_phenotype0.98606604
61MP0000689_abnormal_spleen_morphology0.98239313
62MP0003866_abnormal_defecation0.97632547
63MP0004142_abnormal_muscle_tone0.97383637
64MP0002086_abnormal_extraembryonic_tissu0.97259212
65MP0002398_abnormal_bone_marrow0.94707133
66MP0002282_abnormal_trachea_morphology0.94701208
67MP0000678_abnormal_parathyroid_gland0.93663937
68MP0001324_abnormal_eye_pigmentation0.93358162
69MP0010352_gastrointestinal_tract_polyps0.91840038
70MP0003453_abnormal_keratinocyte_physiol0.89686767
71MP0002111_abnormal_tail_morphology0.87054030
72MP0005076_abnormal_cell_differentiation0.85738188
73MP0000703_abnormal_thymus_morphology0.85675668
74MP0002751_abnormal_autonomic_nervous0.85192066
75MP0002722_abnormal_immune_system0.82043706
76MP0010155_abnormal_intestine_physiology0.80782473
77MP0000681_abnormal_thyroid_gland0.78422921
78MP0004197_abnormal_fetal_growth/weight/0.77392868
79MP0003828_pulmonary_edema0.77270061
80MP0001944_abnormal_pancreas_morphology0.76837342
81MP0005266_abnormal_metabolism0.76831844
82MP0002080_prenatal_lethality0.76508820
83MP0001145_abnormal_male_reproductive0.75782523
84MP0003567_abnormal_fetal_cardiomyocyte0.74316587
85MP0002693_abnormal_pancreas_physiology0.73530904
86MP0006082_CNS_inflammation0.72540001
87MP0002269_muscular_atrophy0.72143110
88MP0002970_abnormal_white_adipose0.70271386
89MP0001873_stomach_inflammation0.68135757
90MP0001986_abnormal_taste_sensitivity0.67699241
91MP0000477_abnormal_intestine_morphology0.67444704
92MP0002114_abnormal_axial_skeleton0.66295435
93MP0003137_abnormal_impulse_conducting0.66030916
94MP0008007_abnormal_cellular_replicative0.65312414
95MP0001672_abnormal_embryogenesis/_devel0.65051983
96MP0005380_embryogenesis_phenotype0.65051983
97MP0001340_abnormal_eyelid_morphology0.64926128
98MP0000716_abnormal_immune_system0.64530516
99MP0002429_abnormal_blood_cell0.64000620
100MP0000049_abnormal_middle_ear0.63144501

Predicted human phenotypes

RankGene SetZ-score
1Poikiloderma (HP:0001029)5.00706227
2Increased IgM level (HP:0003496)4.86124850
3Rib fusion (HP:0000902)4.62798616
4Concave nail (HP:0001598)4.59559229
5Pustule (HP:0200039)4.47262275
6Facial hemangioma (HP:0000329)4.21754197
7Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.13940404
8Rectal fistula (HP:0100590)4.10372736
9Rectovaginal fistula (HP:0000143)4.10372736
10Tongue fasciculations (HP:0001308)3.92172684
11Annular pancreas (HP:0001734)3.87152989
12Mucopolysacchariduria (HP:0008155)3.86074544
13Urinary glycosaminoglycan excretion (HP:0003541)3.86074544
14Vaginal fistula (HP:0004320)3.75882199
15Intestinal fistula (HP:0100819)3.63495472
16Dysostosis multiplex (HP:0000943)3.56324136
17Intestinal atresia (HP:0011100)3.54571946
18Abnormality of glycosaminoglycan metabolism (HP:0004371)3.53623352
19Abnormality of mucopolysaccharide metabolism (HP:0011020)3.53623352
20Abnormality of polysaccharide metabolism (HP:0011012)3.53623352
21Exertional dyspnea (HP:0002875)3.48997948
22Large for gestational age (HP:0001520)3.43227006
23Muscle fibrillation (HP:0010546)3.34756774
24Orthostatic hypotension (HP:0001278)3.32133069
25Growth hormone excess (HP:0000845)3.26893617
26Albinism (HP:0001022)3.26809087
27Abnormal hemoglobin (HP:0011902)3.26580235
28Dysautonomia (HP:0002459)3.17568259
29Turricephaly (HP:0000262)3.15376315
30Abnormality of male internal genitalia (HP:0000022)3.13842393
31Broad alveolar ridges (HP:0000187)3.06592254
32Anteriorly placed anus (HP:0001545)3.05277737
33Absent thumb (HP:0009777)3.01497264
34Type 2 muscle fiber atrophy (HP:0003554)2.93891693
35Muscle fiber atrophy (HP:0100295)2.92908380
36Type I transferrin isoform profile (HP:0003642)2.90480827
37Basal cell carcinoma (HP:0002671)2.88703230
38Pancreatic islet-cell hyperplasia (HP:0004510)2.82264703
39Squamous cell carcinoma (HP:0002860)2.77138610
40Popliteal pterygium (HP:0009756)2.76870830
41Alopecia of scalp (HP:0002293)2.67998904
42Male infertility (HP:0003251)2.62063653
43Alacrima (HP:0000522)2.61881187
44Hypochromic microcytic anemia (HP:0004840)2.59397645
45Aplasia/hypoplasia of the humerus (HP:0006507)2.57778958
46Ulnar bowing (HP:0003031)2.56010680
47Joint stiffness (HP:0001387)2.53905874
48Short humerus (HP:0005792)2.53142428
49Bifid uvula (HP:0000193)2.49767077
50Abnormal respiratory epithelium morphology (HP:0012253)2.49149502
51Abnormal respiratory motile cilium morphology (HP:0005938)2.49149502
52Short chin (HP:0000331)2.46940931
53Acute lymphatic leukemia (HP:0006721)2.45172549
54Premature graying of hair (HP:0002216)2.44363084
55Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.43456495
56Vertebral hypoplasia (HP:0008417)2.43456495
57Capillary hemangiomas (HP:0005306)2.42327053
58Absent radius (HP:0003974)2.39857283
59Median cleft lip (HP:0000161)2.38249726
60Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.35309424
61Abnormal protein N-linked glycosylation (HP:0012347)2.35309424
62Abnormal protein glycosylation (HP:0012346)2.35309424
63Abnormal glycosylation (HP:0012345)2.35309424
64Lower limb hyperreflexia (HP:0002395)2.33190338
65Aplasia involving forearm bones (HP:0009822)2.31406123
66Absent forearm bone (HP:0003953)2.31406123
67Hyperparathyroidism (HP:0000843)2.31087840
68IgA deficiency (HP:0002720)2.30991562
69Congenital hip dislocation (HP:0001374)2.30382825
70Abnormality of endocrine pancreas physiology (HP:0012093)2.29326786
71Abnormality of the pancreatic islet cells (HP:0006476)2.29326786
72Patellar aplasia (HP:0006443)2.26319559
73Hypochromic anemia (HP:0001931)2.24724162
74Amelogenesis imperfecta (HP:0000705)2.24245643
75Hypercortisolism (HP:0001578)2.19079771
76Hypoplasia of the radius (HP:0002984)2.18383287
77Abnormality of T cell physiology (HP:0011840)2.17405940
78Absent rod-and cone-mediated responses on ERG (HP:0007688)2.16941954
79IgG deficiency (HP:0004315)2.16475234
80Premature skin wrinkling (HP:0100678)2.16015359
81Coronal craniosynostosis (HP:0004440)2.13359426
82IgM deficiency (HP:0002850)2.11532976
83Decreased lacrimation (HP:0000633)2.10528549
84Progressive neurologic deterioration (HP:0002344)2.09174129
85Clumsiness (HP:0002312)2.08099209
86Hypotelorism (HP:0000601)2.05551792
87Aplasia/Hypoplasia of the patella (HP:0006498)2.03561296
88Volvulus (HP:0002580)2.03370299
89Abnormality of lateral ventricle (HP:0030047)1.98486364
90Hypokinesia (HP:0002375)1.96166298
91Cerebral hypomyelination (HP:0006808)1.96130371
92Abnormal number of erythroid precursors (HP:0012131)1.94703738
93Polycythemia (HP:0001901)1.93197144
94Hypoplasia of the ulna (HP:0003022)1.91724944
95Vertebral fusion (HP:0002948)1.91293272
96Abnormality of cells of the erythroid lineage (HP:0012130)1.90869670
97Split hand (HP:0001171)1.88659974
98Hamartoma (HP:0010566)1.88292828
99Hypotrichosis (HP:0001006)1.83722706
100Cheilitis (HP:0100825)1.82778226

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK156.97774504
2ICK5.64114578
3MAP3K64.50542472
4DDR23.53132518
5MAP3K113.04431099
6PIM23.03189235
7MATK2.93120214
8UHMK12.72632381
9DAPK12.69217216
10PINK12.65064277
11FGR2.33620310
12DYRK1B2.30203401
13YES12.26293421
14CSK2.06601572
15CDK71.94535676
16PRKD21.92968383
17TYRO31.87735264
18PIM11.49002962
19DYRK31.48332276
20HIPK21.42202565
21MAP3K101.40482770
22RPS6KL11.32195730
23RPS6KC11.32195730
24PDGFRA1.28999689
25RPS6KA61.14887487
26CHEK21.09228597
27BMX1.05312259
28MAPK111.04993746
29MAP4K11.03062815
30CDK61.02000161
31TLK11.01842326
32FLT31.01626880
33TNIK1.01318070
34STK160.98739110
35PASK0.81252838
36CDK120.80593266
37CDK80.80102205
38ATR0.78027058
39LYN0.77617851
40ERBB30.75847688
41GSK3A0.75229094
42RAF10.73664308
43BUB10.71490750
44PLK10.71000718
45CDC42BPA0.69918431
46DYRK20.69033676
47VRK10.68371558
48PHKG20.67430353
49PHKG10.67430353
50RPS6KA10.59704082
51RPS6KB10.55633047
52WEE10.55325928
53BTK0.52912728
54AKT30.51928243
55PRKAA10.50275663
56CSNK2A10.49508359
57TESK20.48646162
58RPS6KB20.48330948
59MAPK40.46236024
60TRPM70.45479640
61TEC0.45358083
62NEK20.44493648
63CDK190.44432040
64KIT0.44364577
65LCK0.42994105
66ZAP700.42110300
67MAPK30.41649828
68NLK0.40692041
69CSNK2A20.39704514
70CDK20.39561913
71PRPF4B0.39503753
72TAOK30.38914216
73MTOR0.37881308
74INSRR0.36618154
75BRD40.36516371
76SCYL20.36149443
77AURKA0.34542095
78MAP3K30.34222241
79TNK20.33259868
80BLK0.32470680
81GRK60.30912427
82MAPKAPK30.29409819
83NME20.27800786
84TAOK20.26632668
85MAPK10.25994818
86MAP3K20.25914619
87WNK30.25882471
88EIF2AK30.25873209
89ATM0.24510348
90EGFR0.22576637
91MAPK140.22101200
92MAPKAPK20.21886984
93MKNK20.21821688
94LATS20.21366829
95PRKCD0.21228581
96IKBKB0.21019847
97ACVR1B0.19730106
98CHEK10.19328935
99SIK20.19166716
100MAP2K20.18763982

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.48751350
2Base excision repair_Homo sapiens_hsa034104.88631035
3DNA replication_Homo sapiens_hsa030304.80786849
4Fatty acid biosynthesis_Homo sapiens_hsa000613.33132220
5Maturity onset diabetes of the young_Homo sapiens_hsa049503.17096444
6Nucleotide excision repair_Homo sapiens_hsa034202.92913928
7Homologous recombination_Homo sapiens_hsa034402.61288306
8Ribosome_Homo sapiens_hsa030102.59835007
9Spliceosome_Homo sapiens_hsa030402.51678071
10Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.40725843
11Folate biosynthesis_Homo sapiens_hsa007902.23501768
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.08127290
13Fanconi anemia pathway_Homo sapiens_hsa034601.96910842
14Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.94209575
15Sulfur relay system_Homo sapiens_hsa041221.93853329
16Protein export_Homo sapiens_hsa030601.86302150
17Circadian rhythm_Homo sapiens_hsa047101.83409691
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.81650391
19RNA transport_Homo sapiens_hsa030131.76673528
20RNA polymerase_Homo sapiens_hsa030201.75935418
21mRNA surveillance pathway_Homo sapiens_hsa030151.62069372
22Primary immunodeficiency_Homo sapiens_hsa053401.59998711
23Notch signaling pathway_Homo sapiens_hsa043301.54306068
24Pyrimidine metabolism_Homo sapiens_hsa002401.44724112
25Arginine and proline metabolism_Homo sapiens_hsa003301.38896713
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.38389168
27N-Glycan biosynthesis_Homo sapiens_hsa005101.38344626
28Cell cycle_Homo sapiens_hsa041101.32343529
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31695345
30Transcriptional misregulation in cancer_Homo sapiens_hsa052021.29283044
31p53 signaling pathway_Homo sapiens_hsa041151.27422987
32Non-homologous end-joining_Homo sapiens_hsa034501.18618407
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.07104896
34Hedgehog signaling pathway_Homo sapiens_hsa043401.06764526
35Basal transcription factors_Homo sapiens_hsa030221.00597687
36Biosynthesis of amino acids_Homo sapiens_hsa012300.96434452
37Glycosaminoglycan degradation_Homo sapiens_hsa005310.94064726
38Proteasome_Homo sapiens_hsa030500.93927591
39mTOR signaling pathway_Homo sapiens_hsa041500.87194873
40Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87098209
41RNA degradation_Homo sapiens_hsa030180.85287980
42Shigellosis_Homo sapiens_hsa051310.83266583
43Fructose and mannose metabolism_Homo sapiens_hsa000510.77737610
44Hippo signaling pathway_Homo sapiens_hsa043900.74027607
45Wnt signaling pathway_Homo sapiens_hsa043100.72652393
46Colorectal cancer_Homo sapiens_hsa052100.70060738
47Bladder cancer_Homo sapiens_hsa052190.67583836
48Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64610774
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.61633918
50One carbon pool by folate_Homo sapiens_hsa006700.61617155
51Fatty acid metabolism_Homo sapiens_hsa012120.61356024
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60719779
53Herpes simplex infection_Homo sapiens_hsa051680.57573958
54Thyroid cancer_Homo sapiens_hsa052160.56395804
55Legionellosis_Homo sapiens_hsa051340.54540128
56Acute myeloid leukemia_Homo sapiens_hsa052210.49972883
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48944524
58Viral carcinogenesis_Homo sapiens_hsa052030.48483073
59Galactose metabolism_Homo sapiens_hsa000520.48265654
60Epstein-Barr virus infection_Homo sapiens_hsa051690.47914510
61Oocyte meiosis_Homo sapiens_hsa041140.47613744
62Purine metabolism_Homo sapiens_hsa002300.47033622
63Huntingtons disease_Homo sapiens_hsa050160.45399808
64Parkinsons disease_Homo sapiens_hsa050120.43829696
65Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.42349209
66Basal cell carcinoma_Homo sapiens_hsa052170.41475374
67Fatty acid elongation_Homo sapiens_hsa000620.41062871
68Adherens junction_Homo sapiens_hsa045200.40217729
69Other glycan degradation_Homo sapiens_hsa005110.38702113
70Lysosome_Homo sapiens_hsa041420.38576697
71Oxidative phosphorylation_Homo sapiens_hsa001900.38267881
72Selenocompound metabolism_Homo sapiens_hsa004500.37622796
73TGF-beta signaling pathway_Homo sapiens_hsa043500.35360616
74Lysine degradation_Homo sapiens_hsa003100.34133210
75Hepatitis B_Homo sapiens_hsa051610.33045711
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.31767203
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31601939
78B cell receptor signaling pathway_Homo sapiens_hsa046620.30035640
79VEGF signaling pathway_Homo sapiens_hsa043700.29203368
80Metabolic pathways_Homo sapiens_hsa011000.28537803
81Antigen processing and presentation_Homo sapiens_hsa046120.28056766
822-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.27026630
83Chronic myeloid leukemia_Homo sapiens_hsa052200.25521381
84Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24224315
85Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.23334850
86Pentose phosphate pathway_Homo sapiens_hsa000300.20561361
87Glutathione metabolism_Homo sapiens_hsa004800.20126747
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.18910822
89Measles_Homo sapiens_hsa051620.18864794
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.17791923
91Gap junction_Homo sapiens_hsa045400.16518128
92Systemic lupus erythematosus_Homo sapiens_hsa053220.15330684
93AMPK signaling pathway_Homo sapiens_hsa041520.12435457
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.12382706
95Insulin signaling pathway_Homo sapiens_hsa049100.11181214
96Alcoholism_Homo sapiens_hsa050340.10509214
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.10371074
98HTLV-I infection_Homo sapiens_hsa051660.10139242
99MicroRNAs in cancer_Homo sapiens_hsa052060.09738431
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.09529630

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