CCDC138

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1auditory receptor cell differentiation (GO:0042491)5.34764309
2kinetochore organization (GO:0051383)5.11530691
3meiotic chromosome segregation (GO:0045132)5.11452069
4DNA strand renaturation (GO:0000733)4.96498228
5kinetochore assembly (GO:0051382)4.73569856
6attachment of spindle microtubules to kinetochore (GO:0008608)4.69451747
7piRNA metabolic process (GO:0034587)4.62932948
8chromatin remodeling at centromere (GO:0031055)4.41079598
9CENP-A containing nucleosome assembly (GO:0034080)4.40002444
10post-embryonic morphogenesis (GO:0009886)4.31828850
11DNA replication checkpoint (GO:0000076)4.31806853
12intra-S DNA damage checkpoint (GO:0031573)4.25630386
13protein K6-linked ubiquitination (GO:0085020)4.21690109
14DNA methylation involved in gamete generation (GO:0043046)4.20091297
15protein localization to chromosome, centromeric region (GO:0071459)4.19579131
16protein localization to kinetochore (GO:0034501)4.19281353
17DNA unwinding involved in DNA replication (GO:0006268)4.06875679
18mitotic metaphase plate congression (GO:0007080)3.97394545
19inner ear receptor stereocilium organization (GO:0060122)3.95717824
20DNA strand elongation involved in DNA replication (GO:0006271)3.95613987
21histone exchange (GO:0043486)3.95490804
22telomere maintenance via semi-conservative replication (GO:0032201)3.91790052
23DNA replication-independent nucleosome organization (GO:0034724)3.91265748
24DNA replication-independent nucleosome assembly (GO:0006336)3.91265748
25microtubule depolymerization (GO:0007019)3.89964338
26DNA replication initiation (GO:0006270)3.85798820
27mitotic chromosome condensation (GO:0007076)3.85787442
28DNA strand elongation (GO:0022616)3.85492148
29cilium or flagellum-dependent cell motility (GO:0001539)3.83190445
30replication fork processing (GO:0031297)3.83080167
31metaphase plate congression (GO:0051310)3.81095642
32mismatch repair (GO:0006298)3.71902225
33centriole assembly (GO:0098534)3.71037931
34DNA double-strand break processing (GO:0000729)3.66585915
35establishment of integrated proviral latency (GO:0075713)3.66243534
36regulation of nuclear cell cycle DNA replication (GO:0033262)3.63934352
37establishment of chromosome localization (GO:0051303)3.63504731
38inner ear receptor cell differentiation (GO:0060113)3.63112324
39reciprocal meiotic recombination (GO:0007131)3.62606070
40reciprocal DNA recombination (GO:0035825)3.62606070
41mitotic recombination (GO:0006312)3.62105801
42negative regulation of DNA-dependent DNA replication (GO:2000104)3.59374060
43single strand break repair (GO:0000012)3.56818305
44regulation of centriole replication (GO:0046599)3.56697804
45DNA synthesis involved in DNA repair (GO:0000731)3.56673514
46telomere maintenance via recombination (GO:0000722)3.54138026
47fusion of sperm to egg plasma membrane (GO:0007342)3.53798487
48DNA replication-dependent nucleosome organization (GO:0034723)3.53188241
49DNA replication-dependent nucleosome assembly (GO:0006335)3.53188241
50male meiosis (GO:0007140)3.52042690
51sister chromatid cohesion (GO:0007062)3.51653599
52maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.46699991
53postreplication repair (GO:0006301)3.46683316
54DNA catabolic process, exonucleolytic (GO:0000738)3.45805163
55regulation of DNA endoreduplication (GO:0032875)3.45561149
56mitotic sister chromatid segregation (GO:0000070)3.44415027
57mitotic spindle checkpoint (GO:0071174)3.43814335
58mitotic sister chromatid cohesion (GO:0007064)3.40180344
59somatic diversification of immune receptors via somatic mutation (GO:0002566)3.36990157
60somatic hypermutation of immunoglobulin genes (GO:0016446)3.36990157
61regulation of mitotic spindle checkpoint (GO:1903504)3.33888850
62regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.33888850
63non-recombinational repair (GO:0000726)3.32921078
64double-strand break repair via nonhomologous end joining (GO:0006303)3.32921078
65daunorubicin metabolic process (GO:0044597)3.32381614
66polyketide metabolic process (GO:0030638)3.32381614
67doxorubicin metabolic process (GO:0044598)3.32381614
68nuclear pore complex assembly (GO:0051292)3.31833494
69centriole replication (GO:0007099)3.28921355
70telomere maintenance via telomere lengthening (GO:0010833)3.28016440
71chromosome organization involved in meiosis (GO:0070192)3.27246867
72purine nucleobase biosynthetic process (GO:0009113)3.27207150
73regulation of double-strand break repair via homologous recombination (GO:0010569)3.23718844
74nucleotide-excision repair, DNA gap filling (GO:0006297)3.22663710
75recombinational repair (GO:0000725)3.22288115
76proteasome assembly (GO:0043248)3.21791640
77nuclear pore organization (GO:0006999)3.21148236
78sister chromatid segregation (GO:0000819)3.21011849
79double-strand break repair via homologous recombination (GO:0000724)3.20380428
80ATP-dependent chromatin remodeling (GO:0043044)3.20247177
81chromosome segregation (GO:0007059)3.20165591
82spindle checkpoint (GO:0031577)3.18424349
83negative regulation of mitotic sister chromatid separation (GO:2000816)3.16465954
84negative regulation of mitotic sister chromatid segregation (GO:0033048)3.16465954
85negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.16465954
86negative regulation of sister chromatid segregation (GO:0033046)3.16465954
87negative regulation of DNA recombination (GO:0045910)3.14421490
88negative regulation of chromosome segregation (GO:0051985)3.13750043
89IMP biosynthetic process (GO:0006188)3.12615042
90meiotic nuclear division (GO:0007126)3.12465126
91negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11499609
92regulation of centrosome cycle (GO:0046605)3.10804068
93DNA geometric change (GO:0032392)3.10183138
94DNA duplex unwinding (GO:0032508)3.08847620
95mitotic nuclear envelope disassembly (GO:0007077)3.08683580
96translesion synthesis (GO:0019985)3.08108271
97nucleobase biosynthetic process (GO:0046112)3.06492508
98resolution of meiotic recombination intermediates (GO:0000712)3.06245324
99inner ear receptor cell development (GO:0060119)3.06241450
100mitotic G2/M transition checkpoint (GO:0044818)3.05654878
101histone H2A acetylation (GO:0043968)3.05225852
102meiotic cell cycle process (GO:1903046)3.03260163
103synaptonemal complex assembly (GO:0007130)3.03087866
104spindle assembly checkpoint (GO:0071173)3.02637744
105histone mRNA metabolic process (GO:0008334)3.00587096
106DNA ligation (GO:0006266)2.99990678
107regulation of mitotic metaphase/anaphase transition (GO:0030071)2.99486569
108deoxyribonucleotide biosynthetic process (GO:0009263)2.99354182
109regulation of chromosome segregation (GO:0051983)2.99172316
110regulation of helicase activity (GO:0051095)2.98715444
111hair cell differentiation (GO:0035315)2.96423070
112cell wall macromolecule metabolic process (GO:0044036)2.96385914
113cell wall macromolecule catabolic process (GO:0016998)2.96385914
114mitotic spindle assembly checkpoint (GO:0007094)2.96123879
115regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.96034834
116sperm-egg recognition (GO:0035036)2.95589124
117protein localization to chromosome (GO:0034502)2.94589188
118regulation of mitotic sister chromatid separation (GO:0010965)2.94444963
119regulation of mitotic sister chromatid segregation (GO:0033047)2.94444963
120regulation of sister chromatid segregation (GO:0033045)2.94444963
121regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.92677869
122response to X-ray (GO:0010165)2.92151593
123chromatin assembly or disassembly (GO:0006333)2.89199844
124rRNA modification (GO:0000154)2.88361745
125negative regulation of mitosis (GO:0045839)2.85686183
126exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.85334457
127spliceosomal snRNP assembly (GO:0000387)2.84688042
128nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.83059876
129regulation of centrosome duplication (GO:0010824)2.81692127
130regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.78804625
131ribosome assembly (GO:0042255)2.78271684
132pseudouridine synthesis (GO:0001522)2.78146459
133microtubule polymerization or depolymerization (GO:0031109)2.76589224
134DNA damage response, detection of DNA damage (GO:0042769)2.76514922

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.38885414
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.29246811
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.28565017
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.54792107
5MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.11363447
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.97244564
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.47205076
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.41476208
9KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.22567256
10ZNF274_21170338_ChIP-Seq_K562_Hela2.21006991
11AR_21909140_ChIP-Seq_LNCAP_Human2.17479134
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.09833858
13E2F7_22180533_ChIP-Seq_HELA_Human11.4459997
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99133174
15PCGF2_27294783_Chip-Seq_ESCs_Mouse1.95145088
16MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88006340
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.86917447
18MYC_19030024_ChIP-ChIP_MESCs_Mouse1.82503490
19ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79310818
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76530250
21VDR_22108803_ChIP-Seq_LS180_Human1.75871837
22BP1_19119308_ChIP-ChIP_Hs578T_Human1.75460651
23EWS_26573619_Chip-Seq_HEK293_Human1.74915705
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.74545420
25IGF1R_20145208_ChIP-Seq_DFB_Human1.72970125
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.66095961
27NFE2_27457419_Chip-Seq_LIVER_Mouse1.60851708
28MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59071823
29TAF15_26573619_Chip-Seq_HEK293_Human1.58315588
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.58026333
31PCGF2_27294783_Chip-Seq_NPCs_Mouse1.55401720
32MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48796827
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48615096
34SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47146514
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46862532
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.46367206
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.46296714
38FUS_26573619_Chip-Seq_HEK293_Human1.44344007
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43605222
40FOXP3_21729870_ChIP-Seq_TREG_Human1.43049948
41NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42601097
42EZH2_22144423_ChIP-Seq_EOC_Human1.41294131
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39992587
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.38705819
45GABP_19822575_ChIP-Seq_HepG2_Human1.37535267
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36862255
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36744834
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.36230991
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.35232511
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.34472613
51GABP_17652178_ChIP-ChIP_JURKAT_Human1.34110339
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.33957140
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32850921
54P300_19829295_ChIP-Seq_ESCs_Human1.32061960
55FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31600973
56* EZH2_27294783_Chip-Seq_NPCs_Mouse1.27698154
57NANOG_16153702_ChIP-ChIP_HESCs_Human1.25068910
58* VDR_23849224_ChIP-Seq_CD4+_Human1.24321523
59ELK1_19687146_ChIP-ChIP_HELA_Human1.22984683
60PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20903238
61MYC_18940864_ChIP-ChIP_HL60_Human1.20754633
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.17539826
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17308178
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17121634
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.15464470
66CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15295504
67KAP1_22055183_ChIP-Seq_ESCs_Mouse1.14006360
68E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12275424
69XRN2_22483619_ChIP-Seq_HELA_Human1.12200662
70TTF2_22483619_ChIP-Seq_HELA_Human1.11881436
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.11531943
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11498726
73E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10982226
74CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.10548851
75STAT3_18555785_Chip-Seq_ESCs_Mouse1.10099517
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09019276
77CIITA_25753668_ChIP-Seq_RAJI_Human1.07055097
78E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06140362
79EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.05801589
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05764474
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05717825
82IRF1_19129219_ChIP-ChIP_H3396_Human1.05189959
83RNF2_27304074_Chip-Seq_NSC_Mouse1.05102799
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03372228
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03220172
86BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01857774
87POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01795462
88OCT4_18555785_Chip-Seq_ESCs_Mouse1.00562865
89PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00083662
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99152523
91BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98288472
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98010104
93NANOG_18555785_Chip-Seq_ESCs_Mouse0.97825160
94E2F1_18555785_Chip-Seq_ESCs_Mouse0.97318115
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.97118304
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97032282
97NMYC_18555785_Chip-Seq_ESCs_Mouse0.96703249
98SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95428641
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.95369595
100TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.95147547
101P300_18555785_Chip-Seq_ESCs_Mouse0.95096459
102ETS1_20019798_ChIP-Seq_JURKAT_Human0.95088463
103ZFX_18555785_Chip-Seq_ESCs_Mouse0.93738588
104* SRF_21415370_ChIP-Seq_HL-1_Mouse0.93332262
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93330845
106ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92191931
107KDM5A_27292631_Chip-Seq_BREAST_Human0.91867301
108NANOG_18555785_ChIP-Seq_MESCs_Mouse0.90524596
109EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.90281009
110P53_22387025_ChIP-Seq_ESCs_Mouse0.89934875
111KLF4_18555785_Chip-Seq_ESCs_Mouse0.89891685
112ESRRB_18555785_Chip-Seq_ESCs_Mouse0.89647350
113* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89445800
114CTCF_18555785_Chip-Seq_ESCs_Mouse0.88510794
115GBX2_23144817_ChIP-Seq_PC3_Human0.88415930
116RUNX1_27457419_Chip-Seq_LIVER_Mouse0.88173724
117CBX2_27304074_Chip-Seq_ESCs_Mouse0.86342830
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86310915
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85771792
120UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85089516
121SOX2_16153702_ChIP-ChIP_HESCs_Human0.84776612
122DCP1A_22483619_ChIP-Seq_HELA_Human0.84517808
123TP53_22573176_ChIP-Seq_HFKS_Human0.83804753
124RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83712540
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83677916
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.83489618
127* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83047384
128SMAD1_18555785_Chip-Seq_ESCs_Mouse0.82656054
129CMYC_18555785_Chip-Seq_ESCs_Mouse0.82634550
130* CRX_20693478_ChIP-Seq_RETINA_Mouse0.82237425
131ZFX_18555785_ChIP-Seq_MESCs_Mouse0.81640561
132SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80607259
133DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80580049
134HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.79128255
135IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.78854325
136CBP_20019798_ChIP-Seq_JUKART_Human0.78854325
137FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.75402447

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.30918574
2MP0008877_abnormal_DNA_methylation4.28474753
3MP0000566_synostosis4.05821343
4MP0008058_abnormal_DNA_repair3.96571543
5MP0003111_abnormal_nucleus_morphology3.93728678
6MP0003693_abnormal_embryo_hatching3.48736908
7MP0006292_abnormal_olfactory_placode3.29849352
8MP0008057_abnormal_DNA_replication3.24563631
9MP0003077_abnormal_cell_cycle3.02078700
10MP0002102_abnormal_ear_morphology2.93271600
11MP0003136_yellow_coat_color2.41148797
12MP0008007_abnormal_cellular_replicative2.40139994
13MP0002938_white_spotting2.33773042
14MP0004957_abnormal_blastocyst_morpholog2.29488662
15MP0003786_premature_aging2.25589648
16MP0008995_early_reproductive_senescence2.18576920
17MP0001986_abnormal_taste_sensitivity2.17168706
18MP0003787_abnormal_imprinting2.13647907
19MP0002210_abnormal_sex_determination2.02680746
20MP0005174_abnormal_tail_pigmentation1.98338971
21MP0009697_abnormal_copulation1.96620290
22MP0003121_genomic_imprinting1.94650136
23MP0001929_abnormal_gametogenesis1.86071745
24MP0002653_abnormal_ependyma_morphology1.85925766
25MP0003123_paternal_imprinting1.82953920
26MP0002396_abnormal_hematopoietic_system1.81555888
27MP0001293_anophthalmia1.73850192
28MP0000049_abnormal_middle_ear1.65221250
29MP0001188_hyperpigmentation1.65178434
30MP0003890_abnormal_embryonic-extraembry1.60658745
31MP0008932_abnormal_embryonic_tissue1.59620054
32MP0001145_abnormal_male_reproductive1.56879020
33MP0005171_absent_coat_pigmentation1.52825998
34MP0003698_abnormal_male_reproductive1.52443083
35MP0000653_abnormal_sex_gland1.51323450
36MP0003718_maternal_effect1.49135373
37MP0000372_irregular_coat_pigmentation1.46065461
38MP0002095_abnormal_skin_pigmentation1.45164294
39MP0008789_abnormal_olfactory_epithelium1.45043420
40MP0000015_abnormal_ear_pigmentation1.43986317
41MP0002234_abnormal_pharynx_morphology1.42707131
42MP0005410_abnormal_fertilization1.38214857
43MP0004742_abnormal_vestibular_system1.38173704
44MP0000350_abnormal_cell_proliferation1.38143443
45MP0003567_abnormal_fetal_cardiomyocyte1.37164345
46MP0003941_abnormal_skin_development1.29517387
47MP0005409_darkened_coat_color1.27529212
48MP0003880_abnormal_central_pattern1.27077171
49MP0001119_abnormal_female_reproductive1.26252696
50MP0005253_abnormal_eye_physiology1.25173191
51MP0002249_abnormal_larynx_morphology1.23737388
52MP0002736_abnormal_nociception_after1.23246597
53MP0005670_abnormal_white_adipose1.22855981
54MP0005551_abnormal_eye_electrophysiolog1.19388891
55MP0002084_abnormal_developmental_patter1.18228337
56MP0001984_abnormal_olfaction1.16651286
57MP0001286_abnormal_eye_development1.15806692
58MP0003763_abnormal_thymus_physiology1.15460388
59MP0003119_abnormal_digestive_system1.14654436
60MP0006035_abnormal_mitochondrial_morpho1.14545731
61MP0003937_abnormal_limbs/digits/tail_de1.13712581
62MP0002163_abnormal_gland_morphology1.13359082
63MP0001346_abnormal_lacrimal_gland1.13140608
64MP0000490_abnormal_crypts_of1.11512964
65MP0002160_abnormal_reproductive_system1.10466891
66MP0000631_abnormal_neuroendocrine_gland1.08814493
67MP0005394_taste/olfaction_phenotype1.07688577
68MP0005499_abnormal_olfactory_system1.07688577
69MP0004133_heterotaxia1.06042336
70MP0000026_abnormal_inner_ear1.05134179
71MP0003315_abnormal_perineum_morphology1.04200178
72MP0002697_abnormal_eye_size1.04199777
73MP0006072_abnormal_retinal_apoptosis1.02711225
74MP0000647_abnormal_sebaceous_gland1.01917620
75MP0001963_abnormal_hearing_physiology0.96120917
76MP0004808_abnormal_hematopoietic_stem0.95349737
77MP0002075_abnormal_coat/hair_pigmentati0.95186981
78MP0002751_abnormal_autonomic_nervous0.95100079
79MP0000313_abnormal_cell_death0.94803929
80MP0002161_abnormal_fertility/fecundity0.93514289
81MP0006276_abnormal_autonomic_nervous0.93502632
82MP0002085_abnormal_embryonic_tissue0.92089053
83MP0002019_abnormal_tumor_incidence0.91761112
84MP0002111_abnormal_tail_morphology0.91733024
85MP0001186_pigmentation_phenotype0.89794301
86MP0000678_abnormal_parathyroid_gland0.89603573
87MP0002088_abnormal_embryonic_growth/wei0.88794868
88MP0001730_embryonic_growth_arrest0.88770511
89MP0001485_abnormal_pinna_reflex0.88656256
90MP0010307_abnormal_tumor_latency0.88547631
91MP0004147_increased_porphyrin_level0.88483161
92MP0000427_abnormal_hair_cycle0.87482041
93MP0009703_decreased_birth_body0.87474818
94MP0002080_prenatal_lethality0.87289977
95MP0002116_abnormal_craniofacial_bone0.87152188
96MP0006036_abnormal_mitochondrial_physio0.85947665
97MP0003938_abnormal_ear_development0.85333915
98MP0005389_reproductive_system_phenotype0.84869487
99MP0001764_abnormal_homeostasis0.84140584
100MP0003861_abnormal_nervous_system0.82925366
101MP0003806_abnormal_nucleotide_metabolis0.81178031
102MP0005075_abnormal_melanosome_morpholog0.80407372
103MP0005248_abnormal_Harderian_gland0.80267546
104MP0010030_abnormal_orbit_morphology0.80254861
105MP0005380_embryogenesis_phenotype0.79666521
106MP0001672_abnormal_embryogenesis/_devel0.79666521
107MP0000383_abnormal_hair_follicle0.79494098
108MP0001968_abnormal_touch/_nociception0.78115371
109MP0000358_abnormal_cell_content/0.77185327
110MP0005379_endocrine/exocrine_gland_phen0.76932923
111MP0005395_other_phenotype0.76755402
112MP0002233_abnormal_nose_morphology0.76710831
113MP0001324_abnormal_eye_pigmentation0.76706463
114MP0000778_abnormal_nervous_system0.75962245
115MP0003186_abnormal_redox_activity0.75794211
116MP0000703_abnormal_thymus_morphology0.74912044
117MP0005084_abnormal_gallbladder_morpholo0.74641779
118MP0002638_abnormal_pupillary_reflex0.74013300
119MP0005645_abnormal_hypothalamus_physiol0.73276639
120MP0003935_abnormal_craniofacial_develop0.72556921
121MP0002090_abnormal_vision0.71698512
122MP0004215_abnormal_myocardial_fiber0.70174247
123MP0001177_atelectasis0.69724308
124MP0003122_maternal_imprinting0.69364520
125MP0003878_abnormal_ear_physiology0.68762095
126MP0005377_hearing/vestibular/ear_phenot0.68762095
127MP0005195_abnormal_posterior_eye0.68553542
128MP0001919_abnormal_reproductive_system0.68313711
129MP0001697_abnormal_embryo_size0.67798558
130MP0009672_abnormal_birth_weight0.67667056
131MP0000432_abnormal_head_morphology0.67065703
132MP0002109_abnormal_limb_morphology0.66966111
133MP0009250_abnormal_appendicular_skeleto0.65574382
134MP0005391_vision/eye_phenotype0.65521203
135MP0003699_abnormal_female_reproductive0.65476745
136MP0003984_embryonic_growth_retardation0.61509465
137MP0001529_abnormal_vocalization0.61432781
138MP0003942_abnormal_urinary_system0.60977447
139MP0004197_abnormal_fetal_growth/weight/0.60447381
140MP0003755_abnormal_palate_morphology0.59778536

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.94745297
2Chromsome breakage (HP:0040012)5.75821417
3Duplicated collecting system (HP:0000081)4.20800217
4Ectopic kidney (HP:0000086)4.11675940
5Aplasia/Hypoplasia of the uvula (HP:0010293)3.98314870
6Abnormality of the renal collecting system (HP:0004742)3.97409848
7Abnormality of chromosome stability (HP:0003220)3.87456876
8Meckel diverticulum (HP:0002245)3.82467920
9Abnormality of the preputium (HP:0100587)3.79895747
10Abnormality of the ileum (HP:0001549)3.61171817
11Abnormality of DNA repair (HP:0003254)3.35970118
12Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.26567524
13Duodenal stenosis (HP:0100867)3.18569704
14Small intestinal stenosis (HP:0012848)3.18569704
1511 pairs of ribs (HP:0000878)3.02827938
16Abnormality of the carotid arteries (HP:0005344)2.99283954
17Clubbing of toes (HP:0100760)2.93806729
18Absent thumb (HP:0009777)2.89903714
19Impulsivity (HP:0100710)2.85583595
20Hypoplasia of the fovea (HP:0007750)2.83861088
21Aplasia/Hypoplasia of the fovea (HP:0008060)2.83861088
22Reticulocytopenia (HP:0001896)2.79558139
23Dynein arm defect of respiratory motile cilia (HP:0012255)2.75199572
24Absent/shortened dynein arms (HP:0200106)2.75199572
25Sloping forehead (HP:0000340)2.70136057
26Supernumerary spleens (HP:0009799)2.69242678
27Abnormality of the duodenum (HP:0002246)2.69048247
28Birth length less than 3rd percentile (HP:0003561)2.60720851
29Abnormality of pyrimidine metabolism (HP:0004353)2.58262553
30True hermaphroditism (HP:0010459)2.58124781
31Pancreatic fibrosis (HP:0100732)2.56971533
32Septo-optic dysplasia (HP:0100842)2.56354922
33Absent radius (HP:0003974)2.52762312
34Facial cleft (HP:0002006)2.47330375
35Abnormal spermatogenesis (HP:0008669)2.46883936
36Horseshoe kidney (HP:0000085)2.41483341
37Aplasia involving forearm bones (HP:0009822)2.40442871
38Absent forearm bone (HP:0003953)2.40442871
39Optic nerve coloboma (HP:0000588)2.39264789
40Medulloblastoma (HP:0002885)2.37889922
41Myelodysplasia (HP:0002863)2.37419217
42Abnormal respiratory motile cilium morphology (HP:0005938)2.35570634
43Abnormal respiratory epithelium morphology (HP:0012253)2.35570634
44Median cleft lip (HP:0000161)2.33713046
45Pendular nystagmus (HP:0012043)2.29732048
46Patellar aplasia (HP:0006443)2.28285449
47Oligodactyly (hands) (HP:0001180)2.28137348
48Increased hepatocellular lipid droplets (HP:0006565)2.28109812
49Pancreatic cysts (HP:0001737)2.26225200
50Short thumb (HP:0009778)2.25957009
51Abnormality of midbrain morphology (HP:0002418)2.25661992
52Molar tooth sign on MRI (HP:0002419)2.25661992
53Azoospermia (HP:0000027)2.22256583
54Nephroblastoma (Wilms tumor) (HP:0002667)2.20408073
55Irregular epiphyses (HP:0010582)2.18603471
56Abnormal lung lobation (HP:0002101)2.18581621
57Abnormal respiratory motile cilium physiology (HP:0012261)2.17799172
58Aplasia/Hypoplasia of the patella (HP:0006498)2.17261758
59Hyperglycinemia (HP:0002154)2.15971169
60Acute necrotizing encephalopathy (HP:0006965)2.15567703
61Bone marrow hypocellularity (HP:0005528)2.15424401
62Duplication of thumb phalanx (HP:0009942)2.13627032
63Colon cancer (HP:0003003)2.12676969
64Preaxial hand polydactyly (HP:0001177)2.12315791
65Ependymoma (HP:0002888)2.12182317
66Hypergonadotropic hypogonadism (HP:0000815)2.11649378
67Abnormality of the fovea (HP:0000493)2.11549911
68Acute encephalopathy (HP:0006846)2.11121771
69Nephronophthisis (HP:0000090)2.10963059
70Aganglionic megacolon (HP:0002251)2.08160335
71Increased CSF lactate (HP:0002490)2.07214318
72Unilateral renal agenesis (HP:0000122)2.06340732
73Triphalangeal thumb (HP:0001199)2.06275669
74Volvulus (HP:0002580)2.04198617
75Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03655778
76Papillary thyroid carcinoma (HP:0002895)2.03322561
77Aplasia/Hypoplasia of the tongue (HP:0010295)2.02698003
78Oligohydramnios (HP:0001562)2.02186362
79Pancreatic islet-cell hyperplasia (HP:0004510)2.01130394
80Flat capital femoral epiphysis (HP:0003370)2.00612642
81Short middle phalanx of the 5th finger (HP:0004220)2.00419865
82Abnormality of methionine metabolism (HP:0010901)1.98730165
83Abnormal ciliary motility (HP:0012262)1.98651764
84Embryonal renal neoplasm (HP:0011794)1.98573482
85Lipid accumulation in hepatocytes (HP:0006561)1.98409134
86Abnormal number of incisors (HP:0011064)1.98349385
87Carpal bone hypoplasia (HP:0001498)1.98333753
88Astigmatism (HP:0000483)1.97757802
89Ureteral duplication (HP:0000073)1.97691489
90Absent septum pellucidum (HP:0001331)1.97038050
91Rhinitis (HP:0012384)1.96997036
92Mitochondrial inheritance (HP:0001427)1.96264552
93Glioma (HP:0009733)1.94883165
94Abnormality of the septum pellucidum (HP:0007375)1.93304066
95Postaxial foot polydactyly (HP:0001830)1.93042531
96Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.91882320
97Aplasia/Hypoplasia of the sternum (HP:0006714)1.91294185
98Absent epiphyses (HP:0010577)1.91204752
99Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.91204752
100Congenital primary aphakia (HP:0007707)1.90998187
101Methylmalonic acidemia (HP:0002912)1.90685640
102Selective tooth agenesis (HP:0001592)1.89288130
103Increased nuchal translucency (HP:0010880)1.89243900
104Nephrogenic diabetes insipidus (HP:0009806)1.89030053
105Optic nerve hypoplasia (HP:0000609)1.88317286
106Abnormality of the renal medulla (HP:0100957)1.87565597
107Genital tract atresia (HP:0001827)1.86857718
108Occipital encephalocele (HP:0002085)1.85370468
109Intestinal atresia (HP:0011100)1.85207442
110Abnormality of serum amino acid levels (HP:0003112)1.84462019
111Abnormal mitochondria in muscle tissue (HP:0008316)1.84078986
112Chronic hepatic failure (HP:0100626)1.82912045
113Arteriovenous malformation (HP:0100026)1.81855995
114Medial flaring of the eyebrow (HP:0010747)1.81617251
115Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81409778
116Premature graying of hair (HP:0002216)1.81371550
117Vaginal atresia (HP:0000148)1.81241067
118Progressive macrocephaly (HP:0004481)1.80155452
119Abnormality of the incisor (HP:0000676)1.80144948
120Gait imbalance (HP:0002141)1.80052242
121Abnormality of the labia minora (HP:0012880)1.79517121
122Small hand (HP:0200055)1.79466966
123Small epiphyses (HP:0010585)1.79205568
124Lip pit (HP:0100267)1.78612166
125Oligodactyly (HP:0012165)1.76590930
126Hypoplastic iliac wings (HP:0002866)1.76530573
127Dandy-Walker malformation (HP:0001305)1.76417557
128Bifid tongue (HP:0010297)1.76273487
129Sclerocornea (HP:0000647)1.75808708
130Patchy hypopigmentation of hair (HP:0011365)1.74126404
131Rhabdomyosarcoma (HP:0002859)1.74113855
132White forelock (HP:0002211)1.73515205
133Increased serum lactate (HP:0002151)1.73326478
134Absent eyebrow (HP:0002223)1.73158042
135Tubulointerstitial nephritis (HP:0001970)1.73156148
136Hepatocellular necrosis (HP:0001404)1.72918370
137Stenosis of the external auditory canal (HP:0000402)1.69970560
138Cortical dysplasia (HP:0002539)1.69110352
139Bile duct proliferation (HP:0001408)1.66671878
140Abnormal biliary tract physiology (HP:0012439)1.66671878
141Astrocytoma (HP:0009592)1.65779624
142Abnormality of the astrocytes (HP:0100707)1.65779624
143Renal Fanconi syndrome (HP:0001994)1.64513127
144Hypoplastic pelvis (HP:0008839)1.63977831
145Anencephaly (HP:0002323)1.63264485
146Oculomotor apraxia (HP:0000657)1.62444633
147Cerebral edema (HP:0002181)1.62276226
148Neoplasm of the colon (HP:0100273)1.61977893
149Dyschromatopsia (HP:0007641)1.61198935

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.09288392
2MKNK23.04366284
3STK38L3.03701262
4WEE13.02666861
5BRSK22.73997605
6NEK22.70574422
7MKNK12.65902733
8PLK42.47781055
9TRIM282.39841928
10TTK2.36523016
11CCNB12.29864118
12BUB12.25207571
13STK162.11608941
14SRPK12.09372453
15SIK32.00432751
16ACVR1B1.97498824
17ZAK1.96970313
18PLK11.89804855
19ATR1.88032491
20TNIK1.86434084
21VRK21.86061381
22CDK81.85275467
23CHEK21.84351195
24EIF2AK21.82897860
25MST41.78402216
26PLK31.74463225
27CDK71.68741803
28PNCK1.67319730
29PASK1.67020904
30BRSK11.66488400
31VRK11.59715039
32EIF2AK11.59151202
33BCR1.57451700
34FRK1.55730204
35PBK1.51505982
36TAOK21.47355954
37DYRK31.46477524
38CDK121.44603343
39STK241.41262864
40NUAK11.39195891
41CHEK11.31125550
42AURKB1.29247025
43MAP4K21.29194546
44MARK31.27898750
45TSSK61.25945853
46ADRBK21.22063322
47RPS6KA41.19716536
48ATM1.18996218
49MAP3K41.09149813
50TAF11.06746313
51YES11.05449053
52CSNK1G11.04001053
53GRK11.03565377
54STK31.02077434
55MAP2K71.00899270
56ERBB30.99754143
57AKT30.99703648
58CDK40.99234218
59LATS10.95145122
60CSNK1G30.94874458
61CSNK1G20.94453843
62CDK30.93075409
63EPHA40.90914377
64NLK0.90349982
65SGK20.90107034
66BRD40.86800210
67AURKA0.86050035
68PRKD30.84326205
69PDK40.84314050
70PDK30.84314050
71CSNK1A1L0.80204923
72BMPR1B0.79751311
73PLK20.79001124
74TGFBR10.78704064
75NME10.78322128
76MAPK130.76567555
77OXSR10.76435843
78CASK0.75231143
79TXK0.72912845
80CDK20.72627813
81STK40.72441069
82TEC0.71323512
83CDK90.70686645
84PINK10.70237546
85EIF2AK30.69740820
86CDK10.67845793
87MELK0.65657094
88BRAF0.65162311
89INSRR0.62747275
90CLK10.62371949
91STK390.60738708
92CSNK2A10.54990825
93CDK190.53044961
94RPS6KB10.53033516
95PIM10.52082402
96NEK60.51301667
97MAP3K80.48076692
98CSNK2A20.46815748
99BMPR20.46740695
100NEK10.46654961
101PRKCG0.42413960
102BCKDK0.42129422
103CSNK1E0.42049613
104FGFR10.41396721
105MUSK0.40650927
106EPHA20.39580568
107FLT30.38342799
108TESK20.37916582
109PRKDC0.36682920
110JAK30.35990975
111SIK20.35802968
112ALK0.34100622
113MINK10.34014443
114FGFR20.33787629
115MAPK140.33752527
116MAP3K120.33441840
117KIT0.33255292
118TLK10.33132532
119WNK40.32583457
120KSR10.31651232
121RPS6KA50.31079365
122STK100.30157522
123AKT10.29403857
124ERBB40.29146957
125CDK60.28768218
126CSNK1A10.28754598
127PDK20.28291702
128PRKCE0.28136859
129DYRK20.26904220
130RPS6KB20.26564240
131GSK3B0.26435060
132CSNK1D0.26260016
133WNK30.26110975
134CAMK1D0.25001335

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.81363952
2Mismatch repair_Homo sapiens_hsa034304.51218756
3Homologous recombination_Homo sapiens_hsa034404.33496416
4Fanconi anemia pathway_Homo sapiens_hsa034604.29477019
5Base excision repair_Homo sapiens_hsa034103.39347120
6Basal transcription factors_Homo sapiens_hsa030223.26530546
7Cell cycle_Homo sapiens_hsa041103.24554006
8Non-homologous end-joining_Homo sapiens_hsa034503.06195300
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.95190694
10Nucleotide excision repair_Homo sapiens_hsa034202.76325131
11RNA polymerase_Homo sapiens_hsa030202.60465772
12Spliceosome_Homo sapiens_hsa030402.54121163
13RNA transport_Homo sapiens_hsa030132.46773125
14Pyrimidine metabolism_Homo sapiens_hsa002402.45751232
15Protein export_Homo sapiens_hsa030602.43705963
16One carbon pool by folate_Homo sapiens_hsa006702.25644252
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.24705259
18RNA degradation_Homo sapiens_hsa030182.20607569
19mRNA surveillance pathway_Homo sapiens_hsa030151.85523386
20p53 signaling pathway_Homo sapiens_hsa041151.79973659
21Propanoate metabolism_Homo sapiens_hsa006401.77118057
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76584332
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.75586507
24Proteasome_Homo sapiens_hsa030501.65556299
25Oxidative phosphorylation_Homo sapiens_hsa001901.65514627
26Purine metabolism_Homo sapiens_hsa002301.64918437
27Parkinsons disease_Homo sapiens_hsa050121.57800966
28Steroid biosynthesis_Homo sapiens_hsa001001.45319750
29Herpes simplex infection_Homo sapiens_hsa051681.25608999
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.20793423
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.20195396
32Selenocompound metabolism_Homo sapiens_hsa004501.20085136
33Fatty acid elongation_Homo sapiens_hsa000621.19842355
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.19167044
35Pyruvate metabolism_Homo sapiens_hsa006201.17081835
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08996334
37Oocyte meiosis_Homo sapiens_hsa041141.03481353
38Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.01370715
39Primary immunodeficiency_Homo sapiens_hsa053400.98827930
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97110650
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89302851
42Pentose phosphate pathway_Homo sapiens_hsa000300.88292849
43Butanoate metabolism_Homo sapiens_hsa006500.86917899
44Systemic lupus erythematosus_Homo sapiens_hsa053220.84293322
45Epstein-Barr virus infection_Homo sapiens_hsa051690.83966165
46Glutathione metabolism_Homo sapiens_hsa004800.81936056
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81153439
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81113253
49Alzheimers disease_Homo sapiens_hsa050100.79310135
50Antigen processing and presentation_Homo sapiens_hsa046120.77635513
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73780925
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73221991
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72317625
54HTLV-I infection_Homo sapiens_hsa051660.70321985
55Linoleic acid metabolism_Homo sapiens_hsa005910.67575905
56Nicotine addiction_Homo sapiens_hsa050330.67481452
57Viral carcinogenesis_Homo sapiens_hsa052030.65700659
58Peroxisome_Homo sapiens_hsa041460.64496931
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63173581
60Ribosome_Homo sapiens_hsa030100.60761072
61Basal cell carcinoma_Homo sapiens_hsa052170.60716645
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60043132
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59889400
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59757300
65Vitamin B6 metabolism_Homo sapiens_hsa007500.58835891
66TGF-beta signaling pathway_Homo sapiens_hsa043500.58179751
67Carbon metabolism_Homo sapiens_hsa012000.57364094
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.57202334
69Nitrogen metabolism_Homo sapiens_hsa009100.55967004
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55279840
71NF-kappa B signaling pathway_Homo sapiens_hsa040640.55009618
72MicroRNAs in cancer_Homo sapiens_hsa052060.54289053
73Phototransduction_Homo sapiens_hsa047440.54288200
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54095675
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53809168
76Circadian rhythm_Homo sapiens_hsa047100.53598227
77Folate biosynthesis_Homo sapiens_hsa007900.52589940
78Fatty acid metabolism_Homo sapiens_hsa012120.52156196
79Caffeine metabolism_Homo sapiens_hsa002320.48789749
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48181827
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.47644282
82Arachidonic acid metabolism_Homo sapiens_hsa005900.47583752
83Tryptophan metabolism_Homo sapiens_hsa003800.46555537
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46074317
85Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46069534
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45598232
87Colorectal cancer_Homo sapiens_hsa052100.45470759
88Ovarian steroidogenesis_Homo sapiens_hsa049130.44826909
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44629168
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43930449
91Hippo signaling pathway_Homo sapiens_hsa043900.43706529
92Maturity onset diabetes of the young_Homo sapiens_hsa049500.43688844
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43611845
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42599744
95Olfactory transduction_Homo sapiens_hsa047400.42220803
96Alcoholism_Homo sapiens_hsa050340.41783173
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.41777288
98Fatty acid degradation_Homo sapiens_hsa000710.40805031
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.39550415
100Measles_Homo sapiens_hsa051620.38482860
101Arginine and proline metabolism_Homo sapiens_hsa003300.37949387
102Ether lipid metabolism_Homo sapiens_hsa005650.37279773
103Hematopoietic cell lineage_Homo sapiens_hsa046400.37146599
104Retinol metabolism_Homo sapiens_hsa008300.36405244
105Hepatitis B_Homo sapiens_hsa051610.34003309
106Wnt signaling pathway_Homo sapiens_hsa043100.32889745
107Autoimmune thyroid disease_Homo sapiens_hsa053200.31857654
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.31325092
109Hedgehog signaling pathway_Homo sapiens_hsa043400.31114566
110Renin-angiotensin system_Homo sapiens_hsa046140.30202903
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.29835042
112Cardiac muscle contraction_Homo sapiens_hsa042600.29547654
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29255525
114Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28448127
115Small cell lung cancer_Homo sapiens_hsa052220.27784334
116Notch signaling pathway_Homo sapiens_hsa043300.27303515
117Chemical carcinogenesis_Homo sapiens_hsa052040.27038542
118Metabolic pathways_Homo sapiens_hsa011000.26389612
119Sulfur relay system_Homo sapiens_hsa041220.26264377
120Lysine degradation_Homo sapiens_hsa003100.25843888
121Influenza A_Homo sapiens_hsa051640.24818850
122N-Glycan biosynthesis_Homo sapiens_hsa005100.24813651
123Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23944024
124Pathways in cancer_Homo sapiens_hsa052000.23742358
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.23626990
126Legionellosis_Homo sapiens_hsa051340.22911853
127Biosynthesis of amino acids_Homo sapiens_hsa012300.22888288
128Cyanoamino acid metabolism_Homo sapiens_hsa004600.22028388
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.21742127
130Taste transduction_Homo sapiens_hsa047420.20845696
131Regulation of autophagy_Homo sapiens_hsa041400.20519078
132Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.20103262
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.17962122
134Huntingtons disease_Homo sapiens_hsa050160.16905399
135Apoptosis_Homo sapiens_hsa042100.16163279
136beta-Alanine metabolism_Homo sapiens_hsa004100.14773352
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.14001138
138Allograft rejection_Homo sapiens_hsa053300.13774672
139Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.13327109
140Prostate cancer_Homo sapiens_hsa052150.12985503
141Vitamin digestion and absorption_Homo sapiens_hsa049770.11853448

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