CCDC122

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that contains a coiled-coil domain. Naturally occurring mutations in this gene are associated with leprosy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tryptophan catabolic process (GO:0006569)5.23184373
2indole-containing compound catabolic process (GO:0042436)5.23184373
3indolalkylamine catabolic process (GO:0046218)5.23184373
4kynurenine metabolic process (GO:0070189)4.96925501
5indolalkylamine metabolic process (GO:0006586)4.82018527
6behavioral response to nicotine (GO:0035095)4.67970587
7detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)4.60104518
8signal peptide processing (GO:0006465)4.49273684
9regulation of RIG-I signaling pathway (GO:0039535)4.35294049
10tryptophan metabolic process (GO:0006568)4.33993824
11antigen processing and presentation of endogenous antigen (GO:0019883)4.16715093
12fucose catabolic process (GO:0019317)4.14203277
13L-fucose metabolic process (GO:0042354)4.14203277
14L-fucose catabolic process (GO:0042355)4.14203277
15neutrophil activation involved in immune response (GO:0002283)4.11276090
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.10828191
17antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.98758981
18antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.98758981
19cilium or flagellum-dependent cell motility (GO:0001539)3.94911322
20neural tube formation (GO:0001841)3.89626079
21regulation of hippo signaling (GO:0035330)3.87981407
22cellular ketone body metabolic process (GO:0046950)3.75845619
23indole-containing compound metabolic process (GO:0042430)3.72180701
24detection of light stimulus involved in visual perception (GO:0050908)3.64333282
25detection of light stimulus involved in sensory perception (GO:0050962)3.64333282
26NIK/NF-kappaB signaling (GO:0038061)3.60740112
27positive regulation of interferon-alpha production (GO:0032727)3.60510160
28reflex (GO:0060004)3.51336706
29regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.47290344
30protein K11-linked deubiquitination (GO:0035871)3.47112138
31positive regulation of natural killer cell differentiation (GO:0032825)3.47037221
32immunoglobulin mediated immune response (GO:0016064)3.45244563
33regulation of gene silencing by RNA (GO:0060966)3.44413365
34regulation of posttranscriptional gene silencing (GO:0060147)3.44413365
35regulation of gene silencing by miRNA (GO:0060964)3.44413365
36ketone body metabolic process (GO:1902224)3.38919599
37behavioral response to ethanol (GO:0048149)3.35816728
38serotonin metabolic process (GO:0042428)3.34757077
39NAD biosynthetic process (GO:0009435)3.33403279
40regulation of interferon-alpha production (GO:0032647)3.33096932
41photoreceptor cell maintenance (GO:0045494)3.32379113
42positive regulation of Cdc42 GTPase activity (GO:0043089)3.31833436
43negative regulation of cytosolic calcium ion concentration (GO:0051481)3.30906894
44epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.30509340
45cellular response to exogenous dsRNA (GO:0071360)3.28386113
46response to interferon-alpha (GO:0035455)3.28324086
47interkinetic nuclear migration (GO:0022027)3.27767581
48primary amino compound metabolic process (GO:1901160)3.27742132
49protein K48-linked deubiquitination (GO:0071108)3.26043827
50positive regulation of antigen processing and presentation (GO:0002579)3.25619216
51cellular biogenic amine catabolic process (GO:0042402)3.25544011
52amine catabolic process (GO:0009310)3.25544011
53snRNA transcription (GO:0009301)3.21654347
54regulation of hypersensitivity (GO:0002883)3.21277366
55negative regulation of translation, ncRNA-mediated (GO:0040033)3.20757169
56regulation of translation, ncRNA-mediated (GO:0045974)3.20757169
57negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.20757169
58negative regulation of mast cell activation (GO:0033004)3.20438393
59positive regulation of developmental pigmentation (GO:0048087)3.19188540
60sulfation (GO:0051923)3.19061732
61regulation of T-helper 1 cell differentiation (GO:0045625)3.17988301
62necroptotic process (GO:0070266)3.17010295
63regulation of pigment cell differentiation (GO:0050932)3.15190328
64regulation of natural killer cell differentiation (GO:0032823)3.14400347
65monoubiquitinated protein deubiquitination (GO:0035520)3.12125168
66negative regulation of myeloid cell apoptotic process (GO:0033033)3.11600092
67oxidative demethylation (GO:0070989)3.10652236
68gamma-aminobutyric acid transport (GO:0015812)3.08706802
69B cell mediated immunity (GO:0019724)3.08229252
70benzene-containing compound metabolic process (GO:0042537)3.08182548
71neuronal action potential (GO:0019228)3.06780345
72reactive oxygen species biosynthetic process (GO:1903409)3.06394377
73leukocyte mediated cytotoxicity (GO:0001909)3.05105885
74establishment of protein localization to Golgi (GO:0072600)3.03507954
75regulation of sarcomere organization (GO:0060297)3.00953091
76thyroid hormone metabolic process (GO:0042403)3.00480110
77type I interferon signaling pathway (GO:0060337)2.99790181
78cellular response to type I interferon (GO:0071357)2.99790181
79response to type I interferon (GO:0034340)2.98577637
80regulation of interferon-beta biosynthetic process (GO:0045357)2.97773661
81axoneme assembly (GO:0035082)2.97222026
82auditory receptor cell stereocilium organization (GO:0060088)2.94661839
83detection of mechanical stimulus involved in sensory perception (GO:0050974)2.93776366
84regulation of dendritic cell antigen processing and presentation (GO:0002604)2.93134446
85growth hormone receptor signaling pathway (GO:0060396)2.92758318
86response to interferon-beta (GO:0035456)2.91615122
87positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.90980324
88hydrogen peroxide biosynthetic process (GO:0050665)2.88416963
89regulation of antigen processing and presentation (GO:0002577)2.87176546
90respiratory burst (GO:0045730)2.85343401
91retinal cone cell development (GO:0046549)2.83783113
92protein K63-linked deubiquitination (GO:0070536)2.81852592
93aromatic amino acid family catabolic process (GO:0009074)2.80386051
94regulation of establishment of cell polarity (GO:2000114)2.79738471
95negative regulation of systemic arterial blood pressure (GO:0003085)2.79679094
96regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.78835485
97response to pheromone (GO:0019236)2.77933486
98tachykinin receptor signaling pathway (GO:0007217)2.76855095
99positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.75681242
100negative regulation of sodium ion transport (GO:0010766)2.75547671
101T-helper 1 type immune response (GO:0042088)2.75397585
102hepatocyte apoptotic process (GO:0097284)2.73835617
103piRNA metabolic process (GO:0034587)2.73584238
104cilium organization (GO:0044782)2.73131139
105urea cycle (GO:0000050)2.73048831
106urea metabolic process (GO:0019627)2.73048831
107positive regulation of humoral immune response (GO:0002922)2.72305255
108epithelial cilium movement (GO:0003351)2.71858233
109membrane depolarization during action potential (GO:0086010)2.71453908
110cilium movement (GO:0003341)2.71257655
111cornea development in camera-type eye (GO:0061303)2.70424145
112cilium morphogenesis (GO:0060271)2.69416934
113modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.69255386
114positive regulation by organism of defense response of other organism involved in symbiotic interact2.69255386
115modulation by symbiont of host immune response (GO:0052553)2.69255386
116positive regulation by symbiont of host defense response (GO:0052509)2.69255386
117modulation by symbiont of host defense response (GO:0052031)2.69255386
118modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.69255386
119response to peptidoglycan (GO:0032494)2.68809895
120flavonoid metabolic process (GO:0009812)2.68366412
121cilium assembly (GO:0042384)2.68279088
122positive regulation of macrophage differentiation (GO:0045651)2.68214683
123nonmotile primary cilium assembly (GO:0035058)2.68174761
124cell killing (GO:0001906)2.67763226
125inner ear receptor stereocilium organization (GO:0060122)2.66783071
126G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.66092978
127neutrophil activation (GO:0042119)2.65741452
128regulation of necroptotic process (GO:0060544)2.65323608
129protein polyglutamylation (GO:0018095)2.64793264
130cellular response to sterol (GO:0036315)2.62141238
131cAMP catabolic process (GO:0006198)2.59687977
132JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.59292703
133myoblast migration (GO:0051451)2.58976884
134granulocyte activation (GO:0036230)2.58929399
135cellular response to interferon-beta (GO:0035458)2.58282706
136L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.57870607
137multicellular organism reproduction (GO:0032504)2.57136205
138positive regulation of T cell mediated cytotoxicity (GO:0001916)2.56857787
139positive regulation of interferon-beta production (GO:0032728)2.56673532
140kidney morphogenesis (GO:0060993)2.55274270
141reciprocal meiotic recombination (GO:0007131)2.54941102
142reciprocal DNA recombination (GO:0035825)2.54941102
143drug catabolic process (GO:0042737)2.54806430
144regulation of establishment or maintenance of cell polarity (GO:0032878)2.53969539
145aromatic amino acid family metabolic process (GO:0009072)2.53687076
146cellular response to growth hormone stimulus (GO:0071378)2.53261306
147regulation of rhodopsin mediated signaling pathway (GO:0022400)2.53120186
148natural killer cell mediated cytotoxicity (GO:0042267)2.52554005
149natural killer cell mediated immunity (GO:0002228)2.52554005
150positive regulation of oligodendrocyte differentiation (GO:0048714)2.52524334
151rhodopsin mediated signaling pathway (GO:0016056)2.52373750
152endosome to melanosome transport (GO:0035646)2.52022951
153endosome to pigment granule transport (GO:0043485)2.52022951
154positive regulation of B cell differentiation (GO:0045579)2.51711793
155spinal cord motor neuron differentiation (GO:0021522)2.51516334
156antigen processing and presentation via MHC class Ib (GO:0002475)2.51430841
157phospholipid efflux (GO:0033700)2.51285672
158response to hyperoxia (GO:0055093)2.50980431
159response to increased oxygen levels (GO:0036296)2.50980431
160DNA methylation involved in gamete generation (GO:0043046)2.50205171
161UDP-N-acetylglucosamine metabolic process (GO:0006047)2.49707309
162regulation of action potential (GO:0098900)2.49601583
163DNA deamination (GO:0045006)2.49596686
164interferon-gamma-mediated signaling pathway (GO:0060333)2.48429329
165positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.48092600
166phosphatidylinositol acyl-chain remodeling (GO:0036149)2.47755509
167defense response to protozoan (GO:0042832)2.47619531
168G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.47319176
169dopamine transport (GO:0015872)2.47247896
170cellular response to zinc ion (GO:0071294)2.46785505
171photoreceptor cell development (GO:0042461)2.45740064
172T cell apoptotic process (GO:0070231)2.45709194
173nitrogen cycle metabolic process (GO:0071941)2.45329232
174limb development (GO:0060173)2.44908765
175appendage development (GO:0048736)2.44908765
176programmed necrotic cell death (GO:0097300)2.44871068
177double-strand break repair via homologous recombination (GO:0000724)2.44856750
178detection of other organism (GO:0098543)2.42796676
179myeloid dendritic cell activation (GO:0001773)2.41735146
180positive regulation of natural killer cell activation (GO:0032816)2.41134798
181regulation of natural killer cell activation (GO:0032814)2.39728428
182positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.38928324
183regulation of B cell differentiation (GO:0045577)2.37822144
184killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.37669800
185disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.37669800
186positive regulation of interleukin-12 production (GO:0032735)2.36970285
187regulation of heterotypic cell-cell adhesion (GO:0034114)2.36861634
188negative regulation of nitric oxide biosynthetic process (GO:0045019)2.36126170
189acute-phase response (GO:0006953)2.32122630
190dendritic cell differentiation (GO:0097028)2.32049735
191ribosomal small subunit assembly (GO:0000028)2.31562682
192detection of bacterium (GO:0016045)2.31503087
193myeloid dendritic cell differentiation (GO:0043011)2.31088781
194superoxide anion generation (GO:0042554)2.30479891
195positive regulation of gamma-delta T cell activation (GO:0046645)2.30042159
196production of molecular mediator involved in inflammatory response (GO:0002532)2.29916886
197response to protozoan (GO:0001562)2.29813360
198JAK-STAT cascade (GO:0007259)2.29768932
199leukocyte mediated immunity (GO:0002443)2.29192436
200lymphocyte mediated immunity (GO:0002449)2.28837962

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.08090435
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.07930379
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.45618276
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.95099398
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.72414037
6GBX2_23144817_ChIP-Seq_PC3_Human3.57575556
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.41693066
8FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.34876764
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.31638390
10VDR_22108803_ChIP-Seq_LS180_Human3.14884474
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.13939224
12ZNF274_21170338_ChIP-Seq_K562_Hela3.12975893
13IRF8_27001747_Chip-Seq_BMDM_Mouse2.84838407
14GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.84138388
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.78282366
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71809117
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.69414824
18EZH2_22144423_ChIP-Seq_EOC_Human2.69372031
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.64689297
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.62087267
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.62065861
22RXR_22158963_ChIP-Seq_LIVER_Mouse2.61844810
23RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.61201246
24MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.59538311
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.47429800
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.41727436
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.39605725
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.38066561
29PPARA_22158963_ChIP-Seq_LIVER_Mouse2.35793983
30FLI1_27457419_Chip-Seq_LIVER_Mouse2.33993843
31* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.32750939
32TAF15_26573619_Chip-Seq_HEK293_Human2.27955544
33EGR1_19374776_ChIP-ChIP_THP-1_Human2.27561395
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.13983829
35GATA1_22025678_ChIP-Seq_K562_Human2.09856932
36P300_19829295_ChIP-Seq_ESCs_Human2.09745164
37AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.08602331
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.04505613
39STAT4_19710469_ChIP-ChIP_TH1__Mouse2.04303662
40SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.02751257
41CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01020006
42FUS_26573619_Chip-Seq_HEK293_Human1.97679941
43EWS_26573619_Chip-Seq_HEK293_Human1.95830333
44ER_23166858_ChIP-Seq_MCF-7_Human1.94202674
45* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.90647654
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.88940307
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.88596870
48STAT3_23295773_ChIP-Seq_U87_Human1.88576411
49SCL_19346495_ChIP-Seq_HPC-7_Human1.88215891
50LXR_22158963_ChIP-Seq_LIVER_Mouse1.86467728
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.86423475
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.85192517
53CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.83727088
54SMAD4_21799915_ChIP-Seq_A2780_Human1.78806607
55PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77598559
56UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70997928
57STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.70806101
58SPI1_23547873_ChIP-Seq_NB4_Human1.69731363
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69315721
60BCAT_22108803_ChIP-Seq_LS180_Human1.68372550
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.66948205
62TCF4_23295773_ChIP-Seq_U87_Human1.66480719
63* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.63300210
64BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62639642
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.60998403
66AR_21572438_ChIP-Seq_LNCaP_Human1.60109092
67SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56165268
68AR_25329375_ChIP-Seq_VCAP_Human1.55068922
69IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52428296
70CBP_20019798_ChIP-Seq_JUKART_Human1.52428296
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.52367931
72TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52367931
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.50254858
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50053087
75NOTCH1_21737748_ChIP-Seq_TLL_Human1.49151761
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49105894
77RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48177384
78SMAD3_21741376_ChIP-Seq_EPCs_Human1.46597566
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46528215
80TP53_16413492_ChIP-PET_HCT116_Human1.45191605
81SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45125604
82PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44137785
83CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.43512261
84MYB_26560356_Chip-Seq_TH2_Human1.42655108
85LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41431507
86EZH2_27294783_Chip-Seq_NPCs_Mouse1.40671393
87TCF4_22108803_ChIP-Seq_LS180_Human1.40166970
88* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.39119059
89CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38416401
90GATA2_22383799_ChIP-Seq_G1ME_Mouse1.38399595
91SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37478634
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36961769
93NFE2_27457419_Chip-Seq_LIVER_Mouse1.34225953
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34091051
95RUNX2_22187159_ChIP-Seq_PCA_Human1.32164854
96PRDM14_20953172_ChIP-Seq_ESCs_Human1.31224992
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30756678
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29850999
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29721098
100EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.29368536
101SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.28692051
102SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.28692051
103TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28593473
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28393623
105TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28285194
106PU_27001747_Chip-Seq_BMDM_Mouse1.26817589
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.26782218
108KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26593288
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26108207
110GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25860613
111FLI1_21867929_ChIP-Seq_TH2_Mouse1.25692505
112SMAD4_21741376_ChIP-Seq_EPCs_Human1.25609897
113CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.25024274
114REST_21632747_ChIP-Seq_MESCs_Mouse1.24890739
115FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24527514
116DROSHA_22980978_ChIP-Seq_HELA_Human1.24354124
117* SOX2_19829295_ChIP-Seq_ESCs_Human1.24250344
118* NANOG_19829295_ChIP-Seq_ESCs_Human1.24250344
119TP53_22573176_ChIP-Seq_HFKS_Human1.23956661
120ESR1_21235772_ChIP-Seq_MCF-7_Human1.23658069
121VDR_24763502_ChIP-Seq_THP-1_Human1.23408567
122MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22859532
123ARNT_22903824_ChIP-Seq_MCF-7_Human1.21608144
124NANOG_18555785_Chip-Seq_ESCs_Mouse1.20164089
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18998506
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18918463
127MYB_26560356_Chip-Seq_TH1_Human1.18300370
128CRX_20693478_ChIP-Seq_RETINA_Mouse1.17729634
129HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17131539
130AHR_22903824_ChIP-Seq_MCF-7_Human1.17062732
131IRF1_19129219_ChIP-ChIP_H3396_Human1.16794550
132NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16761640
133BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16704441
134CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16562606
135VDR_24787735_ChIP-Seq_THP-1_Human1.16549318
136CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16496727
137CBX2_27304074_Chip-Seq_ESCs_Mouse1.16275701
138MAF_26560356_Chip-Seq_TH1_Human1.15622586
139CDX2_22108803_ChIP-Seq_LS180_Human1.14001216
140* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13798921
141RUNX1_22412390_ChIP-Seq_EML_Mouse1.13183051
142* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12445267
143P53_22387025_ChIP-Seq_ESCs_Mouse1.12271375
144CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11673437
145* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11121808
146BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10417827
147CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10060854
148RNF2_27304074_Chip-Seq_NSC_Mouse1.09556428
149SOX2_21211035_ChIP-Seq_LN229_Gbm1.09550994
150SOX2_20726797_ChIP-Seq_SW620_Human1.09514564
151MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09053994
152PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08778415
153BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08380124
154GATA2_21666600_ChIP-Seq_HMVEC_Human1.08292429
155FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08141751
156TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07524543
157FOXA1_25329375_ChIP-Seq_VCAP_Human1.07277560
158FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07277560
159RUNX_20019798_ChIP-Seq_JUKART_Human1.06479192
160E2F1_18555785_Chip-Seq_ESCs_Mouse1.06386781
161OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06166168
162* KDM2B_26808549_Chip-Seq_REH_Human1.05735895
163STAT3_18555785_Chip-Seq_ESCs_Mouse1.04301995
164GATA3_26560356_Chip-Seq_TH2_Human1.03764320
165TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03735053
166FOXM1_26456572_ChIP-Seq_MCF-7_Human1.03485991
167CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.03280218
168KAP1_22055183_ChIP-Seq_ESCs_Mouse1.02375776
169SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.01972251
170ZNF217_24962896_ChIP-Seq_MCF-7_Human0.99709955
171RXR_22108803_ChIP-Seq_LS180_Human0.99327847
172P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98767112
173NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98050582
174NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98050582
175TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96271329
176SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95644007
177PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94907125
178FOXO3_23340844_ChIP-Seq_DLD1_Human0.91619071
179CJUN_26792858_Chip-Seq_BT549_Human0.90941874
180GATA3_27048872_Chip-Seq_THYMUS_Human0.90289199
181ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90241057
182ELF1_17652178_ChIP-ChIP_JURKAT_Human0.90179078
183TRIM28_21343339_ChIP-Seq_HEK293_Human0.88829659
184HOXB4_20404135_ChIP-ChIP_EML_Mouse0.88465537
185SMAD_19615063_ChIP-ChIP_OVARY_Human0.87714921
186SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84834096
187PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82943182
188CLOCK_20551151_ChIP-Seq_293T_Human0.82548627
189GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80440052
190HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.80334226
191TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.79979137
192SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79775204
193IGF1R_20145208_ChIP-Seq_DFB_Human0.79167245
194VDR_21846776_ChIP-Seq_THP-1_Human0.79051622
195ERG_20517297_ChIP-Seq_VCAP_Human0.78719090
196STAT1_17558387_ChIP-Seq_HELA_Human0.77386892
197GATA4_25053715_ChIP-Seq_YYC3_Human0.77302784

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation4.10323615
2MP0001835_abnormal_antigen_presentation3.80844602
3MP0003195_calcinosis3.62074648
4MP0000685_abnormal_immune_system3.08987624
5MP0009785_altered_susceptibility_to2.96628205
6MP0003646_muscle_fatigue2.82086770
7MP0003436_decreased_susceptibility_to2.66302133
8MP0005551_abnormal_eye_electrophysiolog2.64337293
9MP0002148_abnormal_hypersensitivity_rea2.64113907
10MP0009046_muscle_twitch2.54229876
11MP0008877_abnormal_DNA_methylation2.54199093
12MP0001968_abnormal_touch/_nociception2.48043523
13MP0002138_abnormal_hepatobiliary_system2.45483415
14MP0002254_reproductive_system_inflammat2.44064807
15MP0008057_abnormal_DNA_replication2.41764958
16MP0001501_abnormal_sleep_pattern2.37419169
17MP0003191_abnormal_cellular_cholesterol2.33487693
18MP0004043_abnormal_pH_regulation2.31539794
19MP0005360_urolithiasis2.25599218
20MP0005025_abnormal_response_to2.21924968
21MP0003136_yellow_coat_color2.12841404
22MP0003724_increased_susceptibility_to2.11294133
23MP0005000_abnormal_immune_tolerance2.10707926
24MP0002736_abnormal_nociception_after2.07701106
25MP0002102_abnormal_ear_morphology2.06047107
26MP0002006_tumorigenesis2.03621104
27MP0009745_abnormal_behavioral_response2.03564114
28MP0002419_abnormal_innate_immunity2.02923084
29MP0001346_abnormal_lacrimal_gland1.97824507
30MP0005671_abnormal_response_to1.96869397
31MP0001853_heart_inflammation1.94688282
32MP0006082_CNS_inflammation1.93558446
33MP0002139_abnormal_hepatobiliary_system1.91089586
34MP0005387_immune_system_phenotype1.88315516
35MP0001790_abnormal_immune_system1.88315516
36MP0002166_altered_tumor_susceptibility1.87261303
37MP0005646_abnormal_pituitary_gland1.86205902
38MP0005464_abnormal_platelet_physiology1.84403620
39MP0004142_abnormal_muscle_tone1.83978456
40MP0001800_abnormal_humoral_immune1.83627358
41MP0002452_abnormal_antigen_presenting1.81504364
42MP0002877_abnormal_melanocyte_morpholog1.80838581
43MP0002876_abnormal_thyroid_physiology1.76975579
44MP0005174_abnormal_tail_pigmentation1.76393298
45MP0002009_preneoplasia1.76118071
46MP0008872_abnormal_physiological_respon1.75607499
47MP0005253_abnormal_eye_physiology1.75360884
48MP0002723_abnormal_immune_serum1.72044140
49MP0003705_abnormal_hypodermis_morpholog1.71496645
50MP0006292_abnormal_olfactory_placode1.71454361
51MP0001348_abnormal_lacrimal_gland1.70610531
52MP0002837_dystrophic_cardiac_calcinosis1.70282403
53MP0001485_abnormal_pinna_reflex1.69633860
54MP0003303_peritoneal_inflammation1.69483031
55MP0003787_abnormal_imprinting1.67286625
56MP0002938_white_spotting1.63971138
57MP0006276_abnormal_autonomic_nervous1.63596660
58MP0010155_abnormal_intestine_physiology1.58586421
59MP0005365_abnormal_bile_salt1.58544421
60MP0002272_abnormal_nervous_system1.58163904
61MP0009764_decreased_sensitivity_to1.57106878
62MP0006072_abnormal_retinal_apoptosis1.56053531
63MP0001819_abnormal_immune_cell1.55565388
64MP0002420_abnormal_adaptive_immunity1.54413194
65MP0001486_abnormal_startle_reflex1.54281993
66MP0005085_abnormal_gallbladder_physiolo1.54011911
67MP0001845_abnormal_inflammatory_respons1.51894115
68MP0004145_abnormal_muscle_electrophysio1.51798902
69MP0005645_abnormal_hypothalamus_physiol1.50787324
70MP0010352_gastrointestinal_tract_polyps1.49667772
71MP0001986_abnormal_taste_sensitivity1.49645184
72MP0004147_increased_porphyrin_level1.48660742
73MP0009840_abnormal_foam_cell1.48218838
74MP0002638_abnormal_pupillary_reflex1.48158860
75MP0002396_abnormal_hematopoietic_system1.46264879
76MP0010386_abnormal_urinary_bladder1.44908061
77MP0002405_respiratory_system_inflammati1.43935499
78MP0002735_abnormal_chemical_nociception1.41128555
79MP0000631_abnormal_neuroendocrine_gland1.40532875
80MP0001533_abnormal_skeleton_physiology1.39367843
81MP0008469_abnormal_protein_level1.39308199
82MP0003186_abnormal_redox_activity1.37773807
83MP0002064_seizures1.36414394
84MP0004885_abnormal_endolymph1.36293950
85MP0004947_skin_inflammation1.34298749
86MP0002572_abnormal_emotion/affect_behav1.33430738
87MP0008875_abnormal_xenobiotic_pharmacok1.31036179
88MP0003763_abnormal_thymus_physiology1.30845686
89MP0005386_behavior/neurological_phenoty1.30663953
90MP0004924_abnormal_behavior1.30663953
91MP0003880_abnormal_central_pattern1.29526414
92MP0001851_eye_inflammation1.27565299
93MP0010234_abnormal_vibrissa_follicle1.27132194
94MP0001873_stomach_inflammation1.27124226
95MP0001545_abnormal_hematopoietic_system1.24850272
96MP0005397_hematopoietic_system_phenotyp1.24850272
97MP0003453_abnormal_keratinocyte_physiol1.24382206
98MP0001984_abnormal_olfaction1.24358241
99MP0002557_abnormal_social/conspecific_i1.23747151
100MP0003950_abnormal_plasma_membrane1.23632979
101MP0002060_abnormal_skin_morphology1.23285496
102MP0002928_abnormal_bile_duct1.23049648
103MP0005310_abnormal_salivary_gland1.22867473
104MP0000716_abnormal_immune_system1.19284825
105MP0001970_abnormal_pain_threshold1.18337814
106MP0005075_abnormal_melanosome_morpholog1.18302440
107MP0002234_abnormal_pharynx_morphology1.17691688
108MP0004133_heterotaxia1.17425466
109MP0009763_increased_sensitivity_to1.17076025
110MP0002067_abnormal_sensory_capabilities1.17043824
111MP0003941_abnormal_skin_development1.15181814
112MP0003890_abnormal_embryonic-extraembry1.14880463
113MP0000230_abnormal_systemic_arterial1.12974257
114MP0000538_abnormal_urinary_bladder1.12740747
115MP0004381_abnormal_hair_follicle1.12096082
116MP0002398_abnormal_bone_marrow1.11142445
117MP0003252_abnormal_bile_duct1.10829163
118MP0003045_fibrosis1.10116086
119MP0003635_abnormal_synaptic_transmissio1.09858267
120MP0004130_abnormal_muscle_cell1.07574439
121MP0009333_abnormal_splenocyte_physiolog1.05551553
122MP0003566_abnormal_cell_adhesion1.05522544
123MP0002733_abnormal_thermal_nociception1.05304066
124MP0004215_abnormal_myocardial_fiber1.04860754
125MP0003828_pulmonary_edema1.04855017
126MP0002095_abnormal_skin_pigmentation1.04386065
127MP0003300_gastrointestinal_ulcer1.04259501
128MP0004510_myositis1.03540854
129MP0005195_abnormal_posterior_eye1.02166927
130MP0005167_abnormal_blood-brain_barrier1.01603125
131MP0008961_abnormal_basal_metabolism1.00871972
132MP0000343_altered_response_to1.00601977
133MP0005408_hypopigmentation1.00185393
134MP0000858_altered_metastatic_potential0.99702288
135MP0004742_abnormal_vestibular_system0.99136017
136MP0005058_abnormal_lysosome_morphology0.98934945
137MP0003119_abnormal_digestive_system0.98779898
138MP0009379_abnormal_foot_pigmentation0.98563926
139MP0002063_abnormal_learning/memory/cond0.97581527
140MP0000427_abnormal_hair_cycle0.97101336
141MP0001216_abnormal_epidermal_layer0.96984858
142MP0002653_abnormal_ependyma_morphology0.96490704
143MP0000689_abnormal_spleen_morphology0.95979333
144MP0002429_abnormal_blood_cell0.95842934
145MP0005275_abnormal_skin_tensile0.95050210
146MP0002722_abnormal_immune_system0.93890413
147MP0000579_abnormal_nail_morphology0.93104633
148MP0003718_maternal_effect0.91314647
149MP0004808_abnormal_hematopoietic_stem0.90771905
150MP0000609_abnormal_liver_physiology0.90607892
151MP0003137_abnormal_impulse_conducting0.89963859
152MP0005670_abnormal_white_adipose0.88956964
153MP0002229_neurodegeneration0.88168022
154MP0005389_reproductive_system_phenotype0.87991641
155MP0010329_abnormal_lipoprotein_level0.87454998
156MP0005410_abnormal_fertilization0.87111978
157MP0005377_hearing/vestibular/ear_phenot0.86670094
158MP0003878_abnormal_ear_physiology0.86670094
159MP0005171_absent_coat_pigmentation0.85964890
160MP0003937_abnormal_limbs/digits/tail_de0.85608324
161MP0002160_abnormal_reproductive_system0.84936780
162MP0003448_altered_tumor_morphology0.84809754
163MP0002168_other_aberrant_phenotype0.84403244
164MP0006054_spinal_hemorrhage0.83840100
165MP0002752_abnormal_somatic_nervous0.83711360
166MP0005390_skeleton_phenotype0.83333326
167MP0000371_diluted_coat_color0.83182995
168MP0003698_abnormal_male_reproductive0.82776972
169MP0002734_abnormal_mechanical_nocicepti0.82757281
170MP0005266_abnormal_metabolism0.81687985
171MP0000778_abnormal_nervous_system0.81073187
172MP0001881_abnormal_mammary_gland0.80646089
173MP0005023_abnormal_wound_healing0.80616414
174MP0010678_abnormal_skin_adnexa0.80424087
175MP0003633_abnormal_nervous_system0.80278058
176MP0001324_abnormal_eye_pigmentation0.78819416
177MP0004085_abnormal_heartbeat0.78716244
178MP0008775_abnormal_heart_ventricle0.78663736
179MP0003011_delayed_dark_adaptation0.77899412
180MP0003693_abnormal_embryo_hatching0.76687427
181MP0000026_abnormal_inner_ear0.76494876
182MP0010307_abnormal_tumor_latency0.75792498
183MP0000490_abnormal_crypts_of0.75511559
184MP0000372_irregular_coat_pigmentation0.73824602
185MP0001243_abnormal_dermal_layer0.73717074
186MP0009278_abnormal_bone_marrow0.73248660
187MP0009643_abnormal_urine_homeostasis0.72733690
188MP0002019_abnormal_tumor_incidence0.71661413
189MP0009697_abnormal_copulation0.69861411
190MP0005319_abnormal_enzyme/_coenzyme0.69404963
191MP0000383_abnormal_hair_follicle0.68884096
192MP0005332_abnormal_amino_acid0.67905842

Predicted human phenotypes

RankGene SetZ-score
1Recurrent bacterial skin infections (HP:0005406)4.99053268
2Pancreatic cysts (HP:0001737)4.98888470
3Eczematoid dermatitis (HP:0000976)4.75924942
4Myositis (HP:0100614)4.65930031
5Recurrent abscess formation (HP:0002722)4.57487885
6Genetic anticipation (HP:0003743)4.44540316
7Pancreatic fibrosis (HP:0100732)4.42513295
8True hermaphroditism (HP:0010459)4.34119760
9Molar tooth sign on MRI (HP:0002419)4.05678039
10Abnormality of midbrain morphology (HP:0002418)4.05678039
11Recurrent gram-negative bacterial infections (HP:0005420)4.00849458
12Congenital stationary night blindness (HP:0007642)3.93975357
13Hyperventilation (HP:0002883)3.87919292
14Elevated erythrocyte sedimentation rate (HP:0003565)3.84624780
15Gaze-evoked nystagmus (HP:0000640)3.69320471
16Thrombocytosis (HP:0001894)3.64347513
17Progressive cerebellar ataxia (HP:0002073)3.57088495
18Nephronophthisis (HP:0000090)3.55433084
19Chronic hepatic failure (HP:0100626)3.53707932
20Attenuation of retinal blood vessels (HP:0007843)3.45032197
21Abnormality of macrophages (HP:0004311)3.44827520
22Abnormality of the renal cortex (HP:0011035)3.44508592
23Orchitis (HP:0100796)3.43152087
24Abnormality of the renal medulla (HP:0100957)3.30780925
25Recurrent skin infections (HP:0001581)3.28666252
26Cystic liver disease (HP:0006706)3.28492345
27Chronic otitis media (HP:0000389)3.17781854
28Mediastinal lymphadenopathy (HP:0100721)3.12433480
29Optic neuritis (HP:0100653)3.03951748
30Retrobulbar optic neuritis (HP:0100654)3.03951748
31Aplasia/Hypoplasia of the tibia (HP:0005772)2.98416549
32Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.97530568
33Gingival bleeding (HP:0000225)2.93110508
34Arterial thrombosis (HP:0004420)2.91785472
35Clumsiness (HP:0002312)2.90584700
36Type II lissencephaly (HP:0007260)2.87494472
37Protruding tongue (HP:0010808)2.87453458
38Abolished electroretinogram (ERG) (HP:0000550)2.85001971
39Medial flaring of the eyebrow (HP:0010747)2.84662568
40Lip pit (HP:0100267)2.82445328
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.82092693
42Abnormality of alanine metabolism (HP:0010916)2.82092693
43Hyperalaninemia (HP:0003348)2.82092693
44Prolonged partial thromboplastin time (HP:0003645)2.81952204
45Joint hemorrhage (HP:0005261)2.78162011
46Vasculitis (HP:0002633)2.76767772
47Myocardial infarction (HP:0001658)2.75494660
48Autoimmune thrombocytopenia (HP:0001973)2.75233892
49Tubular atrophy (HP:0000092)2.74939933
50Increased neuronal autofluorescent lipopigment (HP:0002074)2.68495742
51Abnormality of aromatic amino acid family metabolism (HP:0004338)2.67895657
52Abnormal hemoglobin (HP:0011902)2.67631445
53Congenital sensorineural hearing impairment (HP:0008527)2.66817413
54Increased corneal curvature (HP:0100692)2.66756106
55Keratoconus (HP:0000563)2.66756106
56Epidermoid cyst (HP:0200040)2.60917374
57Recurrent fungal infections (HP:0002841)2.60420394
58Abnormality of monocarboxylic acid metabolism (HP:0010996)2.58814896
59Inability to walk (HP:0002540)2.58206372
60Aplasia/Hypoplasia of the tongue (HP:0010295)2.58185631
61Deep venous thrombosis (HP:0002625)2.58183455
62Febrile seizures (HP:0002373)2.56401495
63Peritonitis (HP:0002586)2.56139197
64Periodontitis (HP:0000704)2.53665992
65Sclerocornea (HP:0000647)2.51241282
66Furrowed tongue (HP:0000221)2.51218869
67Large for gestational age (HP:0001520)2.44672595
68Xanthomatosis (HP:0000991)2.44480843
69Vacuolated lymphocytes (HP:0001922)2.44205443
70Progressive inability to walk (HP:0002505)2.43963123
71Bony spicule pigmentary retinopathy (HP:0007737)2.43134423
72Abnormal drinking behavior (HP:0030082)2.42947718
73Polydipsia (HP:0001959)2.42947718
74Pulmonary infiltrates (HP:0002113)2.42447587
75Vertebral compression fractures (HP:0002953)2.42226489
76Fair hair (HP:0002286)2.42079746
77Epistaxis (HP:0000421)2.41568534
78Cerebellar dysplasia (HP:0007033)2.41167712
79Congenital hepatic fibrosis (HP:0002612)2.38846584
80Abnormality of the prostate (HP:0008775)2.38442766
81Hematochezia (HP:0002573)2.38158716
82Increased IgE level (HP:0003212)2.37666201
83Autoimmune hemolytic anemia (HP:0001890)2.37382629
84Spontaneous abortion (HP:0005268)2.34895944
85Decreased circulating renin level (HP:0003351)2.34868409
86Disinhibition (HP:0000734)2.32963623
87Prostate neoplasm (HP:0100787)2.32759076
88Gait imbalance (HP:0002141)2.32630349
89Broad-based gait (HP:0002136)2.31152854
90Pendular nystagmus (HP:0012043)2.30011267
91Hypergammaglobulinemia (HP:0010702)2.29806716
92Nasal polyposis (HP:0100582)2.29401458
93Chorioretinal atrophy (HP:0000533)2.28250205
94Decreased central vision (HP:0007663)2.27935715
95Congenital primary aphakia (HP:0007707)2.27160567
96Abnormality of the common coagulation pathway (HP:0010990)2.27053602
97Absent/shortened dynein arms (HP:0200106)2.25383247
98Dynein arm defect of respiratory motile cilia (HP:0012255)2.25383247
99Reduced antithrombin III activity (HP:0001976)2.24514920
100Renal cortical cysts (HP:0000803)2.23818195
101Absent speech (HP:0001344)2.23562674
102Meningitis (HP:0001287)2.23520112
103Bile duct proliferation (HP:0001408)2.22407917
104Abnormal biliary tract physiology (HP:0012439)2.22407917
105Stomach cancer (HP:0012126)2.22277232
106Abnormal platelet function (HP:0011869)2.21667942
107Impaired platelet aggregation (HP:0003540)2.21667942
108Thrombophlebitis (HP:0004418)2.21502001
109Amyloidosis (HP:0011034)2.21130531
110Keratoconjunctivitis (HP:0001096)2.20518886
111Interstitial pulmonary disease (HP:0006530)2.20510453
112Urticaria (HP:0001025)2.20445199
113Cellulitis (HP:0100658)2.19463954
114Patellar aplasia (HP:0006443)2.18782017
115Anencephaly (HP:0002323)2.18283868
116Azoospermia (HP:0000027)2.17917695
117Pustule (HP:0200039)2.17897094
118Tetraparesis (HP:0002273)2.16780920
119Nephritis (HP:0000123)2.16343620
120Prolonged bleeding time (HP:0003010)2.14318901
121Gastrointestinal infarctions (HP:0005244)2.14270640
122Focal seizures (HP:0007359)2.13577021
123Genital tract atresia (HP:0001827)2.11389298
124Decreased electroretinogram (ERG) amplitude (HP:0000654)2.09836956
125Male pseudohermaphroditism (HP:0000037)2.09772468
126Dialeptic seizures (HP:0011146)2.09513721
127Acute myeloid leukemia (HP:0004808)2.09003766
128Birth length less than 3rd percentile (HP:0003561)2.08693258
129Hypoplasia of the pons (HP:0012110)2.08391501
130Lissencephaly (HP:0001339)2.08086333
131Congenital, generalized hypertrichosis (HP:0004540)2.07495137
132Hypoplastic ischia (HP:0003175)2.06850203
133Obstructive lung disease (HP:0006536)2.06068060
134Chronic obstructive pulmonary disease (HP:0006510)2.06068060
135Abnormality of the pons (HP:0007361)2.05995586
136Nephrogenic diabetes insipidus (HP:0009806)2.05595989
137Aplasia/Hypoplasia of the patella (HP:0006498)2.05560301
138Postaxial foot polydactyly (HP:0001830)2.05000819
139Osteolytic defects of the hand bones (HP:0009699)2.04540799
140Osteolytic defects of the phalanges of the hand (HP:0009771)2.04540799
141Abnormality of the nasal mucosa (HP:0000433)2.02814226
142Intrahepatic cholestasis (HP:0001406)2.02437360
143Chronic mucocutaneous candidiasis (HP:0002728)2.02347146
144Recurrent cutaneous fungal infections (HP:0011370)2.02347146
145Vaginal atresia (HP:0000148)2.01823214
146Abnormal delayed hypersensitivity skin test (HP:0002963)2.00988680
147Central scotoma (HP:0000603)2.00913048
148Keratoconjunctivitis sicca (HP:0001097)2.00611988
149Abnormal rod and cone electroretinograms (HP:0008323)2.00129883
150Hypercholesterolemia (HP:0003124)1.99339104
151Menorrhagia (HP:0000132)1.95935752
152Type I diabetes mellitus (HP:0100651)1.95656044
153Preaxial foot polydactyly (HP:0001841)1.95552176
154Recurrent bronchitis (HP:0002837)1.95200757
155Recurrent viral infections (HP:0004429)1.94105633
156Gingivitis (HP:0000230)1.94002073
157Esophageal varix (HP:0002040)1.92847017
158Generalized aminoaciduria (HP:0002909)1.92765295
159Abnormal ciliary motility (HP:0012262)1.92629704
160Generalized hypopigmentation of hair (HP:0011358)1.91588850
161Abnormality of macular pigmentation (HP:0008002)1.91306486
162Polyuria (HP:0000103)1.90940898
163Xerostomia (HP:0000217)1.90299491
164Pulmonary fibrosis (HP:0002206)1.90017864
165Abnormality of the intrinsic pathway (HP:0010989)1.89684558
166Joint swelling (HP:0001386)1.87499479
167Abnormality of T cell physiology (HP:0011840)1.86859806
168Widely spaced teeth (HP:0000687)1.85954544
169Abnormality of pyrimidine metabolism (HP:0004353)1.83807647
170Abnormality of iron homeostasis (HP:0011031)1.83764423
171Hypochromic anemia (HP:0001931)1.83683827
172Spondylolisthesis (HP:0003302)1.83509327
173Preaxial hand polydactyly (HP:0001177)1.83434167
174Abnormality of the ischium (HP:0003174)1.83384335
175Pulmonary embolism (HP:0002204)1.82888789
176Osteomyelitis (HP:0002754)1.82847376
177Pancreatitis (HP:0001733)1.82739722
178Increased IgM level (HP:0003496)1.82156463
179Small hand (HP:0200055)1.82139332
180Abnormal spermatogenesis (HP:0008669)1.82028589
181Gangrene (HP:0100758)1.81737260
182Increased cerebral lipofuscin (HP:0011813)1.81640375
183Systemic lupus erythematosus (HP:0002725)1.81213401
184Hypothermia (HP:0002045)1.81097919
185Hemoptysis (HP:0002105)1.80089789
186Glomerulonephritis (HP:0000099)1.79953933
187Abnormality of complement system (HP:0005339)1.79393579
188Recurrent lower respiratory tract infections (HP:0002783)1.78424718
189Poor coordination (HP:0002370)1.78312031
190Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78250991
191Absence seizures (HP:0002121)1.75716391
192Focal motor seizures (HP:0011153)1.74725785
193Hemiparesis (HP:0001269)1.74055416
194Dandy-Walker malformation (HP:0001305)1.73108106
195Aplasia/Hypoplasia of the uvula (HP:0010293)1.69930103
196Concave nail (HP:0001598)1.69559242
197Severe muscular hypotonia (HP:0006829)1.69538942
198Short foot (HP:0001773)1.68923093
199Abnormal respiratory motile cilium morphology (HP:0005938)1.68604599
200Abnormal respiratory epithelium morphology (HP:0012253)1.68604599

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK9.64893208
2MAP3K143.25543499
3ADRBK23.00847293
4FLT32.90808973
5NEK92.70631174
6ACVR1B2.65776992
7TYK22.63930991
8TRIB32.49639537
9TBK12.47303731
10KIT2.37656334
11RIPK42.29960663
12PIM22.25473087
13MAP3K132.24097727
14TAOK32.17450270
15NLK2.13150128
16WNK32.08802955
17BLK2.06767783
18GRK12.03156023
19JAK32.02036999
20INSRR2.01076279
21ERN11.98498530
22CASK1.93830837
23ZAK1.85651232
24PBK1.85565450
25IKBKB1.83423511
26MAP4K21.83339290
27IRAK41.81161020
28PASK1.76027843
29MAPK131.73230473
30IKBKE1.68268937
31OXSR11.68249918
32MAP4K11.66269077
33PKN21.65286194
34MST1R1.63349172
35MST41.57066497
36MKNK21.55442369
37TEC1.51422624
38NTRK31.50447719
39TLK11.48525114
40PINK11.46702754
41STK391.46456388
42CHUK1.45835851
43WNK41.43025147
44ADRBK11.42596907
45BCKDK1.42254851
46CSF1R1.38971099
47STK38L1.36698504
48EPHA31.34032566
49JAK11.31426412
50DAPK21.30061729
51IRAK31.27118518
52NME21.26508562
53LRRK21.26010579
54LATS11.25550157
55PIK3CG1.25389224
56TGFBR11.25170982
57ABL21.24429086
58MAP3K41.23695794
59MAP3K61.15611180
60BTK1.15105371
61MOS1.15103017
62ZAP701.14417626
63TNIK1.09916061
64MELK1.07688213
65PTK61.07673121
66JAK21.07666344
67STK31.02870694
68AKT31.02472633
69PIK3CA1.01701689
70PTK2B1.00292177
71NUAK10.98369340
72PIM10.97350875
73BMPR1B0.96451619
74MATK0.94617109
75PRKCE0.93161830
76SYK0.93078403
77STK40.92822994
78TRPM70.92760840
79VRK10.92522332
80PAK30.92514036
81CDK60.89689187
82MUSK0.88197461
83MAP2K30.86648633
84RIPK10.83838600
85BRSK20.82774584
86BMPR20.82456541
87PRKCG0.81628038
88IRAK10.81575277
89PNCK0.81495702
90CAMKK20.81102475
91FGFR40.80033545
92MAP2K20.78909721
93ERBB40.78050751
94LYN0.76684366
95STK100.76496363
96MARK10.74974158
97RPS6KA40.73219913
98FGFR20.72563015
99MAP3K30.72361011
100RAF10.71997957
101LCK0.71678089
102FER0.67584491
103TIE10.67025554
104STK160.65783506
105ABL10.65753904
106TXK0.64087305
107EIF2AK20.63196980
108DYRK1B0.62518415
109TGFBR20.61024650
110MKNK10.61017765
111TNK20.59663030
112MAPKAPK30.58418582
113OBSCN0.57832723
114HCK0.57778296
115CAMK1G0.57579419
116CAMK2A0.56911544
117SGK20.56893992
118HIPK20.56782451
119MAP3K10.56320073
120ARAF0.53731880
121TRIM280.53442449
122MAP3K50.52981129
123EPHA40.52705978
124MAP3K70.52093185
125PLK20.51496189
126PKN10.50479211
127FGFR30.49279307
128CDK40.48691462
129CAMK1D0.48674994
130CAMK10.48334285
131PRKAA20.48180067
132STK110.47713812
133CAMKK10.46747566
134ERBB20.43684149
135ITK0.43302370
136MAPKAPK50.43187017
137RET0.42608756
138TESK10.42605306
139PRKAA10.41456923
140EPHB10.40040416
141CSNK1D0.39382552
142EEF2K0.38561600
143MAPKAPK20.38361721
144PRKACA0.38097978
145SIK20.37951188
146CSNK1G20.37383040
147STK380.36280640
148GRK70.36248254
149IGF1R0.35935896
150SCYL20.35368258
151CSK0.35362378
152MAPK40.34690621
153CSNK1A1L0.34530331
154MAP2K10.34349444
155MAP2K70.34285330
156WEE10.33983342
157CSNK1G10.33811730
158PRKCD0.33212234
159MAP2K60.33125779
160PRKCQ0.32857998
161MARK30.32430994
162RPS6KB20.31408964
163PHKG20.31303311
164PHKG10.31303311
165ILK0.31117731
166NTRK20.30894031
167PLK40.30669269
168DYRK30.30568395
169PRKG10.30102968
170ERBB30.29823105
171CSNK1A10.29149217
172RPS6KA50.28245098
173PDK10.28078771
174PRKCA0.27894978
175PRKCZ0.27875081
176BCR0.27235400
177PRKACB0.26946915
178CAMK40.26060343

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.79631230
2Butanoate metabolism_Homo sapiens_hsa006502.76721203
3Linoleic acid metabolism_Homo sapiens_hsa005912.65417786
4Nicotine addiction_Homo sapiens_hsa050332.55579652
5Nitrogen metabolism_Homo sapiens_hsa009102.53029264
6alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.49630938
7Leishmaniasis_Homo sapiens_hsa051402.34259842
8Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.33256753
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30269856
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.30127226
11Staphylococcus aureus infection_Homo sapiens_hsa051502.18244825
12Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.15564756
13Primary bile acid biosynthesis_Homo sapiens_hsa001202.13556246
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.07721889
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.03941202
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.96798882
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.92462326
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.86084406
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.83378092
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.83369759
21Taste transduction_Homo sapiens_hsa047421.82789620
22Ether lipid metabolism_Homo sapiens_hsa005651.81867921
23Complement and coagulation cascades_Homo sapiens_hsa046101.78434895
24Allograft rejection_Homo sapiens_hsa053301.77699341
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76219742
26Chemical carcinogenesis_Homo sapiens_hsa052041.74896516
27Olfactory transduction_Homo sapiens_hsa047401.69919775
28Morphine addiction_Homo sapiens_hsa050321.69682861
29Jak-STAT signaling pathway_Homo sapiens_hsa046301.68553236
30Caffeine metabolism_Homo sapiens_hsa002321.68297771
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.66337885
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.64827765
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.56774958
34Graft-versus-host disease_Homo sapiens_hsa053321.56264010
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.54887534
36Malaria_Homo sapiens_hsa051441.54342803
37Measles_Homo sapiens_hsa051621.52432749
38Legionellosis_Homo sapiens_hsa051341.51922070
39Histidine metabolism_Homo sapiens_hsa003401.51172383
40Osteoclast differentiation_Homo sapiens_hsa043801.44051972
41Hematopoietic cell lineage_Homo sapiens_hsa046401.43537503
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42531843
43Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40277409
44Toxoplasmosis_Homo sapiens_hsa051451.38239507
45Herpes simplex infection_Homo sapiens_hsa051681.36415046
46Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36277186
47Pertussis_Homo sapiens_hsa051331.34440876
48TNF signaling pathway_Homo sapiens_hsa046681.33640576
49Circadian entrainment_Homo sapiens_hsa047131.33196239
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.32301624
51Tryptophan metabolism_Homo sapiens_hsa003801.31218149
52Serotonergic synapse_Homo sapiens_hsa047261.31049531
53Fanconi anemia pathway_Homo sapiens_hsa034601.30465003
54Glutamatergic synapse_Homo sapiens_hsa047241.28593751
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.26554330
56Antigen processing and presentation_Homo sapiens_hsa046121.23030782
57Influenza A_Homo sapiens_hsa051641.22925209
58Retinol metabolism_Homo sapiens_hsa008301.22755388
59Propanoate metabolism_Homo sapiens_hsa006401.20166290
60Peroxisome_Homo sapiens_hsa041461.19371362
61GABAergic synapse_Homo sapiens_hsa047271.18673587
62Homologous recombination_Homo sapiens_hsa034401.17475610
63Calcium signaling pathway_Homo sapiens_hsa040201.16340618
64Phenylalanine metabolism_Homo sapiens_hsa003601.16196917
65Glycerolipid metabolism_Homo sapiens_hsa005611.15776305
66Starch and sucrose metabolism_Homo sapiens_hsa005001.14134846
67Ovarian steroidogenesis_Homo sapiens_hsa049131.13431297
68Salivary secretion_Homo sapiens_hsa049701.13230038
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11354119
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.10438021
71Insulin secretion_Homo sapiens_hsa049111.07989449
72Folate biosynthesis_Homo sapiens_hsa007901.05720901
73Sulfur relay system_Homo sapiens_hsa041221.03948081
74Tuberculosis_Homo sapiens_hsa051521.03147212
75Primary immunodeficiency_Homo sapiens_hsa053401.02542190
76Glutathione metabolism_Homo sapiens_hsa004801.01235328
77Arachidonic acid metabolism_Homo sapiens_hsa005901.01157916
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00698313
79Apoptosis_Homo sapiens_hsa042101.00147162
80Ribosome_Homo sapiens_hsa030100.97548596
81Basal transcription factors_Homo sapiens_hsa030220.95126784
82Asthma_Homo sapiens_hsa053100.91433172
83B cell receptor signaling pathway_Homo sapiens_hsa046620.91050923
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.91029798
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.90878212
86p53 signaling pathway_Homo sapiens_hsa041150.89964001
87Hepatitis B_Homo sapiens_hsa051610.88044794
88RNA polymerase_Homo sapiens_hsa030200.86569578
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.86390209
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86233635
91Dorso-ventral axis formation_Homo sapiens_hsa043200.86120298
92Prolactin signaling pathway_Homo sapiens_hsa049170.83599181
93DNA replication_Homo sapiens_hsa030300.83453964
94Type I diabetes mellitus_Homo sapiens_hsa049400.83276760
95beta-Alanine metabolism_Homo sapiens_hsa004100.82002814
96Hepatitis C_Homo sapiens_hsa051600.80146380
97Lysine degradation_Homo sapiens_hsa003100.79810405
98ABC transporters_Homo sapiens_hsa020100.78962954
99Fatty acid biosynthesis_Homo sapiens_hsa000610.78711400
100Tyrosine metabolism_Homo sapiens_hsa003500.78487976
101One carbon pool by folate_Homo sapiens_hsa006700.76738860
102Other glycan degradation_Homo sapiens_hsa005110.75798701
103Shigellosis_Homo sapiens_hsa051310.74868252
104Fatty acid degradation_Homo sapiens_hsa000710.73528413
105Rheumatoid arthritis_Homo sapiens_hsa053230.71437501
106Arginine biosynthesis_Homo sapiens_hsa002200.69492716
107Pentose phosphate pathway_Homo sapiens_hsa000300.69423066
108Salmonella infection_Homo sapiens_hsa051320.69273241
109PPAR signaling pathway_Homo sapiens_hsa033200.69086411
110Long-term depression_Homo sapiens_hsa047300.68379712
111Chemokine signaling pathway_Homo sapiens_hsa040620.67977556
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.65535467
113Cholinergic synapse_Homo sapiens_hsa047250.65458014
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63383350
115Small cell lung cancer_Homo sapiens_hsa052220.62732729
116Amoebiasis_Homo sapiens_hsa051460.62610602
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62581571
118Gastric acid secretion_Homo sapiens_hsa049710.62115496
119Dopaminergic synapse_Homo sapiens_hsa047280.60846861
120Protein export_Homo sapiens_hsa030600.60673502
121cAMP signaling pathway_Homo sapiens_hsa040240.60264584
122Sphingolipid metabolism_Homo sapiens_hsa006000.60200434
123Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59982598
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59929225
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59483355
126African trypanosomiasis_Homo sapiens_hsa051430.59197732
127Oxytocin signaling pathway_Homo sapiens_hsa049210.58881070
128Circadian rhythm_Homo sapiens_hsa047100.58613202
129Maturity onset diabetes of the young_Homo sapiens_hsa049500.58119564
130Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.57377440
131Autoimmune thyroid disease_Homo sapiens_hsa053200.57012982
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56479149
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55107963
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.55100666
135Lysosome_Homo sapiens_hsa041420.54844658
136Regulation of autophagy_Homo sapiens_hsa041400.54710744
137Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54490925
138RNA degradation_Homo sapiens_hsa030180.53685249
139Pancreatic cancer_Homo sapiens_hsa052120.53312678
140Glycerophospholipid metabolism_Homo sapiens_hsa005640.52979168
141Fat digestion and absorption_Homo sapiens_hsa049750.52841879
142Selenocompound metabolism_Homo sapiens_hsa004500.51367898
143Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50518177
144Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49963215
145Platelet activation_Homo sapiens_hsa046110.49905092
146Pyrimidine metabolism_Homo sapiens_hsa002400.48946937
147Cyanoamino acid metabolism_Homo sapiens_hsa004600.47852653
148Renin secretion_Homo sapiens_hsa049240.47437208
149Pancreatic secretion_Homo sapiens_hsa049720.44564722
150Acute myeloid leukemia_Homo sapiens_hsa052210.44540213
151Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44283653
152Mineral absorption_Homo sapiens_hsa049780.44161720
153SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43067608
154Vitamin digestion and absorption_Homo sapiens_hsa049770.40057383
155Purine metabolism_Homo sapiens_hsa002300.39687035
156Cocaine addiction_Homo sapiens_hsa050300.39556222
157Non-homologous end-joining_Homo sapiens_hsa034500.39439937
158Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36034055
159Metabolic pathways_Homo sapiens_hsa011000.35671214
160Amphetamine addiction_Homo sapiens_hsa050310.34097585
161Type II diabetes mellitus_Homo sapiens_hsa049300.33165678
162cGMP-PKG signaling pathway_Homo sapiens_hsa040220.31698093
163Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30303698
164Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29939344
165Bile secretion_Homo sapiens_hsa049760.28064010
166Ras signaling pathway_Homo sapiens_hsa040140.24307805
167Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23614627
168TGF-beta signaling pathway_Homo sapiens_hsa043500.23521427

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