CCDC12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.13150982
2chaperone-mediated protein transport (GO:0072321)5.39546273
3DNA deamination (GO:0045006)5.34428417
4viral transcription (GO:0019083)4.93632514
5translational termination (GO:0006415)4.71395456
6purine deoxyribonucleotide catabolic process (GO:0009155)4.61316854
7ribosomal small subunit biogenesis (GO:0042274)4.60017138
8base-excision repair, AP site formation (GO:0006285)4.48037352
9SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.41780477
10cotranslational protein targeting to membrane (GO:0006613)4.31775532
11protein targeting to ER (GO:0045047)4.29094630
12protoporphyrinogen IX biosynthetic process (GO:0006782)4.28357303
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.14078526
14protein localization to endoplasmic reticulum (GO:0070972)4.08100914
15translational elongation (GO:0006414)4.05890967
16establishment of protein localization to endoplasmic reticulum (GO:0072599)4.03777665
17maturation of SSU-rRNA (GO:0030490)4.02536019
18protein complex biogenesis (GO:0070271)3.98439860
19mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.96488553
20ATP synthesis coupled proton transport (GO:0015986)3.86341011
21energy coupled proton transport, down electrochemical gradient (GO:0015985)3.86341011
22centriole replication (GO:0007099)3.84795265
23viral life cycle (GO:0019058)3.80884536
24proteasome assembly (GO:0043248)3.78995449
25mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.73940904
26mitochondrial respiratory chain complex I assembly (GO:0032981)3.73940904
27NADH dehydrogenase complex assembly (GO:0010257)3.73940904
28respiratory electron transport chain (GO:0022904)3.73360701
29mitochondrial respiratory chain complex assembly (GO:0033108)3.69158592
30telomere maintenance via semi-conservative replication (GO:0032201)3.69129693
31electron transport chain (GO:0022900)3.66660595
32establishment of protein localization to mitochondrial membrane (GO:0090151)3.62612669
33antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.61432838
34nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.59681447
35deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.57483992
36cellular protein complex disassembly (GO:0043624)3.57445056
37purine deoxyribonucleotide metabolic process (GO:0009151)3.57188143
38N-acetylneuraminate metabolic process (GO:0006054)3.56035905
39deoxyribose phosphate catabolic process (GO:0046386)3.54673156
40translational initiation (GO:0006413)3.52949967
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.48869098
42antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.44866312
43ribosomal large subunit biogenesis (GO:0042273)3.42781656
44regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.41645919
45telomere maintenance via recombination (GO:0000722)3.40341284
46DNA strand elongation involved in DNA replication (GO:0006271)3.35963092
47protein deneddylation (GO:0000338)3.34779004
48response to interferon-beta (GO:0035456)3.33325180
49protein targeting to mitochondrion (GO:0006626)3.26069958
50translation (GO:0006412)3.25378518
51deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.24878225
52DNA strand elongation (GO:0022616)3.21000201
53sequestering of actin monomers (GO:0042989)3.18278899
54protoporphyrinogen IX metabolic process (GO:0046501)3.17769145
55heme biosynthetic process (GO:0006783)3.16537831
56negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.15249462
57regulation of mitochondrial translation (GO:0070129)3.13128821
58protein complex disassembly (GO:0043241)3.12276630
59establishment of protein localization to mitochondrion (GO:0072655)3.08542517
60amino sugar catabolic process (GO:0046348)3.06991273
61purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.05137604
62ribonucleoprotein complex biogenesis (GO:0022613)3.04965052
63RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.04055876
64tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.04055876
65mannosylation (GO:0097502)3.03856763
66peptidyl-histidine modification (GO:0018202)3.02175169
672-deoxyribonucleotide metabolic process (GO:0009394)3.01888137
68positive regulation of prostaglandin secretion (GO:0032308)2.97417004
69DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.97399444
70exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.96801220
71cytidine metabolic process (GO:0046087)2.95999004
72cytidine catabolic process (GO:0006216)2.95999004
73cytidine deamination (GO:0009972)2.95999004
74macromolecular complex disassembly (GO:0032984)2.95408005
75nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.94167002
76somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.93684538
77somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.93684538
78isotype switching (GO:0045190)2.93684538
79antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.93600552
80antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.93600552
81mitotic recombination (GO:0006312)2.92672799
82positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.92426389
83intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.91710479
84signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.91710479
85signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.91074720
86signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.91074720
87signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.91074720
88protein localization to mitochondrion (GO:0070585)2.90987908
89deoxyribose phosphate metabolic process (GO:0019692)2.89133759
90antigen processing and presentation of endogenous antigen (GO:0019883)2.87899931
91respiratory chain complex IV assembly (GO:0008535)2.87874285
92negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.87334521
93negative regulation of ligase activity (GO:0051352)2.87334521
94nuclear-transcribed mRNA catabolic process (GO:0000956)2.87212380
95negative regulation of telomere maintenance (GO:0032205)2.86987983
96positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.84997243
97negative regulation of B cell apoptotic process (GO:0002903)2.84536100
98termination of RNA polymerase III transcription (GO:0006386)2.84385623
99transcription elongation from RNA polymerase III promoter (GO:0006385)2.84385623
100regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.83893349
101neutrophil activation involved in immune response (GO:0002283)2.83503164
102protein-cofactor linkage (GO:0018065)2.83308164
103rRNA methylation (GO:0031167)2.82231768
104immunoglobulin mediated immune response (GO:0016064)2.81206791
105formation of translation preinitiation complex (GO:0001731)2.80090727
106heme metabolic process (GO:0042168)2.78708835
107signal transduction involved in DNA integrity checkpoint (GO:0072401)2.78060874
108signal transduction involved in DNA damage checkpoint (GO:0072422)2.78060874
109transcription-coupled nucleotide-excision repair (GO:0006283)2.77141164
110regulation of cellular amino acid metabolic process (GO:0006521)2.76278514
111mRNA catabolic process (GO:0006402)2.75539296
112cellular response to interferon-beta (GO:0035458)2.73869018
113signal transduction involved in cell cycle checkpoint (GO:0072395)2.73771714
114anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73758935
115protein targeting to membrane (GO:0006612)2.73639101
116centriole assembly (GO:0098534)2.73507674
117Arp2/3 complex-mediated actin nucleation (GO:0034314)2.73012116
118B cell mediated immunity (GO:0019724)2.72166499
119antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.72056029
1207-methylguanosine mRNA capping (GO:0006370)2.71816893
121regulation of MHC class II biosynthetic process (GO:0045346)2.71572752
1227-methylguanosine RNA capping (GO:0009452)2.69474110
123RNA capping (GO:0036260)2.69474110
124telomere maintenance via telomere lengthening (GO:0010833)2.68177685
125negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.67725162
126negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.67542290
127water-soluble vitamin biosynthetic process (GO:0042364)2.65639269
128hydrogen ion transmembrane transport (GO:1902600)2.64678113
129tRNA processing (GO:0008033)2.63528834
130rRNA processing (GO:0006364)2.62874104
131positive regulation of ligase activity (GO:0051351)2.62867433
132pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.62563395
133defense response to protozoan (GO:0042832)2.62545079
134protein neddylation (GO:0045116)2.62270369
135deoxyribonucleotide metabolic process (GO:0009262)2.61903753
136RNA catabolic process (GO:0006401)2.61851158
137platelet dense granule organization (GO:0060155)2.61438258
138pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.61321868
139preassembly of GPI anchor in ER membrane (GO:0016254)2.59716280
140cellular component biogenesis (GO:0044085)2.59676403
141pseudouridine synthesis (GO:0001522)2.59360680
142cytochrome complex assembly (GO:0017004)2.58867798
143nucleotide-excision repair, DNA gap filling (GO:0006297)2.55484927
144transcription from mitochondrial promoter (GO:0006390)2.55286169
145establishment of viral latency (GO:0019043)2.54213278
146ATP hydrolysis coupled proton transport (GO:0015991)2.54167449
147energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.54167449
148positive regulation of gamma-delta T cell activation (GO:0046645)2.53775453
149rRNA metabolic process (GO:0016072)2.52182179
150signal peptide processing (GO:0006465)2.48228054
151DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.47526148
152rRNA modification (GO:0000154)2.45888735
153metallo-sulfur cluster assembly (GO:0031163)2.44104283
154iron-sulfur cluster assembly (GO:0016226)2.44104283
155DNA replication initiation (GO:0006270)2.43510664
156response to protozoan (GO:0001562)2.43390462
157regulation of B cell receptor signaling pathway (GO:0050855)2.41448231
158deoxyribonucleotide catabolic process (GO:0009264)2.40819144
159positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.40511813
160negative regulation of myeloid cell apoptotic process (GO:0033033)2.40495681
161mast cell activation (GO:0045576)2.40154323
162spliceosomal snRNP assembly (GO:0000387)2.38500322

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.69754601
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.32601828
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.31086538
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.29210301
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.26823493
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.22692879
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.17339767
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.11477330
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.99466234
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86783450
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.74759188
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.72504869
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.64419934
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.62088760
15IRF8_21731497_ChIP-ChIP_J774_Mouse2.46575637
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.42975890
17* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.40977712
18* FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.37443622
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.34737108
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33895779
21VDR_23849224_ChIP-Seq_CD4+_Human2.28229702
22BP1_19119308_ChIP-ChIP_Hs578T_Human2.25465754
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.24327817
24CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.21877000
25TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.19632515
26MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11700877
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.09912278
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.07606468
29* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.06243217
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.04003599
31SPI1_23547873_ChIP-Seq_NB4_Human2.01170420
32SRF_21415370_ChIP-Seq_HL-1_Mouse1.95964656
33* XRN2_22483619_ChIP-Seq_HELA_Human1.93825132
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.93096479
35HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87036113
36* FOXP3_21729870_ChIP-Seq_TREG_Human1.86154417
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.85321001
38* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.81311778
39* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.78991502
40DCP1A_22483619_ChIP-Seq_HELA_Human1.76297251
41STAT4_19710469_ChIP-ChIP_TH1__Mouse1.75591239
42SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.75568219
43* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.73563987
44CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.72552432
45FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.70500270
46NELFA_20434984_ChIP-Seq_ESCs_Mouse1.69323071
47ZNF274_21170338_ChIP-Seq_K562_Hela1.68944726
48ELK1_19687146_ChIP-ChIP_HELA_Human1.67233643
49E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.66049817
50* GABP_19822575_ChIP-Seq_HepG2_Human1.61943365
51* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.59439255
52VDR_21846776_ChIP-Seq_THP-1_Human1.59206546
53FOXM1_23109430_ChIP-Seq_U2OS_Human1.57850271
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.57227962
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.57207137
56MYC_18940864_ChIP-ChIP_HL60_Human1.55178324
57TTF2_22483619_ChIP-Seq_HELA_Human1.49708887
58THAP11_20581084_ChIP-Seq_MESCs_Mouse1.47261939
59EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.45578772
60* SCL_19346495_ChIP-Seq_HPC-7_Human1.44584448
61ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.42856719
62* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.41474444
63CIITA_25753668_ChIP-Seq_RAJI_Human1.41155009
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.41132263
65MYB_26560356_Chip-Seq_TH2_Human1.33464423
66MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32997047
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.32603521
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26866682
69* BCL6_27268052_Chip-Seq_Bcells_Human1.26337348
70ELF1_20517297_ChIP-Seq_JURKAT_Human1.24539544
71IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.23089187
72MYC_22102868_ChIP-Seq_BL_Human1.22826695
73ELK1_22589737_ChIP-Seq_MCF10A_Human1.22008788
74SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.20946717
75MAF_26560356_Chip-Seq_TH1_Human1.20499077
76YY1_22570637_ChIP-Seq_MALME-3M_Human1.20379172
77* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19857886
78IRF1_19129219_ChIP-ChIP_H3396_Human1.19536019
79PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18970322
80* IRF8_27001747_Chip-Seq_BMDM_Mouse1.18859757
81HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.18676211
82RUNX1_22412390_ChIP-Seq_EML_Mouse1.18353033
83* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17919333
84* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17438302
85RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.17378860
86TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16993741
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.16235114
88* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.16232302
89* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14851980
90IGF1R_20145208_ChIP-Seq_DFB_Human1.14210294
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13587688
92* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13443476
93CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13438675
94MYB_26560356_Chip-Seq_TH1_Human1.13362096
95MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12920350
96TP53_22573176_ChIP-Seq_HFKS_Human1.12275479
97STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11474748
98VDR_24763502_ChIP-Seq_THP-1_Human1.11415911
99SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08536195
100NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.08310110
101NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.08292931
102POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08171381
103ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04909015
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04223680
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03971608
106MAF_26560356_Chip-Seq_TH2_Human1.03585833
107GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03333909
108TFEB_21752829_ChIP-Seq_HELA_Human1.01337680
109* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01272399
110NANOG_20526341_ChIP-Seq_ESCs_Human1.00897303
111PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00767181
112UTX_26944678_Chip-Seq_JUKART_Human1.00656960
113FOXP1_21924763_ChIP-Seq_HESCs_Human1.00099612
114E2F1_20622854_ChIP-Seq_HELA_Human0.99627239
115MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98837158
116E2F1_21310950_ChIP-Seq_MCF-7_Human0.98061799
117* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96684510
118EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95934025
119CTCF_18555785_ChIP-Seq_MESCs_Mouse0.95918740
120HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94946938
121CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94527078
122KDM5A_27292631_Chip-Seq_BREAST_Human0.94007423
123CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93707779
124GATA3_26560356_Chip-Seq_TH2_Human0.91612136
125E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90861853
126BCOR_27268052_Chip-Seq_Bcells_Human0.90682530
127CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90581698
128* P300_27268052_Chip-Seq_Bcells_Human0.87272512
129SA1_27219007_Chip-Seq_Bcells_Human0.86349893
130TAF2_19829295_ChIP-Seq_ESCs_Human0.85098157
131ETV2_25802403_ChIP-Seq_MESCs_Mouse0.84441801
132SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84281112

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract4.17495885
2MP0001835_abnormal_antigen_presentation4.13684411
3MP0003693_abnormal_embryo_hatching3.25887906
4MP0009785_altered_susceptibility_to3.21753472
5MP0005671_abnormal_response_to3.04904297
6MP0002148_abnormal_hypersensitivity_rea2.95677332
7MP0000685_abnormal_immune_system2.74108458
8MP0005025_abnormal_response_to2.58481876
9MP0003763_abnormal_thymus_physiology2.56331993
10MP0003436_decreased_susceptibility_to2.55888478
11MP0005000_abnormal_immune_tolerance2.54381879
12MP0003806_abnormal_nucleotide_metabolis2.50550010
13MP0009333_abnormal_splenocyte_physiolog2.47758289
14MP0002452_abnormal_antigen_presenting2.35523891
15MP0001800_abnormal_humoral_immune2.34422907
16MP0002396_abnormal_hematopoietic_system2.29542954
17MP0002723_abnormal_immune_serum2.28589470
18MP0001819_abnormal_immune_cell2.28265400
19MP0002420_abnormal_adaptive_immunity2.28061882
20MP0001790_abnormal_immune_system2.19660172
21MP0005387_immune_system_phenotype2.19660172
22MP0002419_abnormal_innate_immunity2.17795377
23MP0004957_abnormal_blastocyst_morpholog2.14374490
24MP0001853_heart_inflammation2.13828195
25MP0002398_abnormal_bone_marrow2.10170044
26MP0008995_early_reproductive_senescence2.06799233
27MP0003724_increased_susceptibility_to2.02867142
28MP0008058_abnormal_DNA_repair1.92110724
29MP0003077_abnormal_cell_cycle1.91431500
30MP0000716_abnormal_immune_system1.90694813
31MP0002132_abnormal_respiratory_system1.87328375
32MP0005365_abnormal_bile_salt1.85320002
33MP0000689_abnormal_spleen_morphology1.80261652
34MP0000490_abnormal_crypts_of1.79270303
35MP0005464_abnormal_platelet_physiology1.78351556
36MP0002405_respiratory_system_inflammati1.76909808
37MP0002722_abnormal_immune_system1.75965514
38MP0010094_abnormal_chromosome_stability1.75314516
39MP0002429_abnormal_blood_cell1.73112306
40MP0005174_abnormal_tail_pigmentation1.70714633
41MP0006035_abnormal_mitochondrial_morpho1.70234029
42MP0010155_abnormal_intestine_physiology1.66997487
43MP0003186_abnormal_redox_activity1.66780374
44MP0008872_abnormal_physiological_respon1.62608922
45MP0005670_abnormal_white_adipose1.62501964
46MP0001529_abnormal_vocalization1.61169159
47MP0009379_abnormal_foot_pigmentation1.61107464
48MP0002166_altered_tumor_susceptibility1.59788365
49MP0008007_abnormal_cellular_replicative1.59668008
50MP0003111_abnormal_nucleus_morphology1.59598305
51MP0000858_altered_metastatic_potential1.55227833
52MP0006292_abnormal_olfactory_placode1.53420710
53MP0003195_calcinosis1.53008012
54MP0003787_abnormal_imprinting1.52587338
55MP0002006_tumorigenesis1.52393346
56MP0001845_abnormal_inflammatory_respons1.51048185
57MP0006082_CNS_inflammation1.50702784
58MP0005645_abnormal_hypothalamus_physiol1.49559991
59MP0008961_abnormal_basal_metabolism1.49253967
60MP0005075_abnormal_melanosome_morpholog1.48060075
61MP0001545_abnormal_hematopoietic_system1.46351603
62MP0005397_hematopoietic_system_phenotyp1.46351603
63MP0004808_abnormal_hematopoietic_stem1.45975957
64MP0005310_abnormal_salivary_gland1.45433610
65MP0001905_abnormal_dopamine_level1.43883238
66MP0003252_abnormal_bile_duct1.43357571
67MP0003866_abnormal_defecation1.42240200
68MP0001873_stomach_inflammation1.41477712
69MP0004043_abnormal_pH_regulation1.40858317
70MP0008875_abnormal_xenobiotic_pharmacok1.40710553
71MP0008057_abnormal_DNA_replication1.37299624
72MP0002163_abnormal_gland_morphology1.34891661
73MP0002019_abnormal_tumor_incidence1.33403994
74MP0000703_abnormal_thymus_morphology1.32789779
75MP0002254_reproductive_system_inflammat1.26429950
76MP0003786_premature_aging1.26108335
77MP0008469_abnormal_protein_level1.24114137
78MP0006072_abnormal_retinal_apoptosis1.23524318
79MP0005085_abnormal_gallbladder_physiolo1.22775450
80MP0008789_abnormal_olfactory_epithelium1.21691731
81MP0004510_myositis1.20958619
82MP0000343_altered_response_to1.18595273
83MP0000313_abnormal_cell_death1.13918387
84MP0000465_gastrointestinal_hemorrhage1.13117189
85MP0002837_dystrophic_cardiac_calcinosis1.12363414
86MP0002653_abnormal_ependyma_morphology1.09566485
87MP0004147_increased_porphyrin_level1.08131021
88MP0003123_paternal_imprinting1.05102239
89MP0002095_abnormal_skin_pigmentation1.04313583
90MP0005410_abnormal_fertilization1.04005902
91MP0005646_abnormal_pituitary_gland1.03448146
92MP0001533_abnormal_skeleton_physiology1.02178681
93MP0006036_abnormal_mitochondrial_physio1.01843377
94MP0002876_abnormal_thyroid_physiology0.99574663
95MP0002736_abnormal_nociception_after0.98906393
96MP0003448_altered_tumor_morphology0.98383107
97MP0000015_abnormal_ear_pigmentation0.98319202
98MP0005551_abnormal_eye_electrophysiolog0.97587701
99MP0002138_abnormal_hepatobiliary_system0.97559290
100MP0002693_abnormal_pancreas_physiology0.96722304
101MP0004947_skin_inflammation0.95890235
102MP0004142_abnormal_muscle_tone0.95531531
103MP0008932_abnormal_embryonic_tissue0.94193599
104MP0005636_abnormal_mineral_homeostasis0.93653167
105MP0000516_abnormal_urinary_system0.93445345
106MP0005367_renal/urinary_system_phenotyp0.93445345
107MP0001929_abnormal_gametogenesis0.93370122
108MP0005253_abnormal_eye_physiology0.93262877
109MP0001986_abnormal_taste_sensitivity0.91848416
110MP0002933_joint_inflammation0.88602966
111MP0010329_abnormal_lipoprotein_level0.88384710
112MP0002210_abnormal_sex_determination0.88044781
113MP0000372_irregular_coat_pigmentation0.87571884
114MP0004782_abnormal_surfactant_physiolog0.87492188
115MP0002277_abnormal_respiratory_mucosa0.84378504
116MP0000358_abnormal_cell_content/0.83280637
117MP0009643_abnormal_urine_homeostasis0.82584526
118MP0001919_abnormal_reproductive_system0.81877370
119MP0005266_abnormal_metabolism0.81539908
120MP0003011_delayed_dark_adaptation0.80530223
121MP0006054_spinal_hemorrhage0.80022841
122MP0005377_hearing/vestibular/ear_phenot0.79972572
123MP0003828_pulmonary_edema0.77728721
124MP0004381_abnormal_hair_follicle0.75975056
125MP0005379_endocrine/exocrine_gland_phen0.73524386
126MP0008877_abnormal_DNA_methylation0.73397180
127MP0009764_decreased_sensitivity_to0.72787809
128MP0005084_abnormal_gallbladder_morpholo0.70311442
129MP0001348_abnormal_lacrimal_gland0.69978651
130MP0000350_abnormal_cell_proliferation0.69216851
131MP0003567_abnormal_fetal_cardiomyocyte0.66060848
132MP0008260_abnormal_autophagy0.65954063
133MP0001663_abnormal_digestive_system0.65947144
134MP0003183_abnormal_peptide_metabolism0.62221883
135MP0003656_abnormal_erythrocyte_physiolo0.62190859
136MP0003943_abnormal_hepatobiliary_system0.60445357
137MP0009763_increased_sensitivity_to0.59665851
138MP0003718_maternal_effect0.57748773
139MP0009697_abnormal_copulation0.56392424
140MP0002638_abnormal_pupillary_reflex0.56168392
141MP0005451_abnormal_body_composition0.55995139
142MP0001764_abnormal_homeostasis0.55827794
143MP0005058_abnormal_lysosome_morphology0.55823894
144MP0001851_eye_inflammation0.55388026
145MP0001346_abnormal_lacrimal_gland0.53665096

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.68337982
2Abnormal number of erythroid precursors (HP:0012131)4.55212911
3Recurrent abscess formation (HP:0002722)4.41152752
4Elevated erythrocyte sedimentation rate (HP:0003565)4.30555103
5Reticulocytopenia (HP:0001896)4.22306065
6IgM deficiency (HP:0002850)3.80513870
7Recurrent bacterial skin infections (HP:0005406)3.79025881
8Progressive macrocephaly (HP:0004481)3.78964808
9Increased muscle lipid content (HP:0009058)3.54024388
10Thrombocytosis (HP:0001894)3.51379798
11Myositis (HP:0100614)3.44519218
12Petechiae (HP:0000967)3.42859794
13Cerebral edema (HP:0002181)3.35476611
14Eczematoid dermatitis (HP:0000976)3.34471455
15Aplastic anemia (HP:0001915)3.18258595
16Lactic acidosis (HP:0003128)3.17396743
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.08046704
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.08046704
19Pallor (HP:0000980)3.01044183
20Type I transferrin isoform profile (HP:0003642)3.00440306
21Hepatocellular necrosis (HP:0001404)2.97602007
22Abnormality of macrophages (HP:0004311)2.92967498
23Exertional dyspnea (HP:0002875)2.91588657
243-Methylglutaconic aciduria (HP:0003535)2.90599974
25Macrocytic anemia (HP:0001972)2.87073790
26Microvesicular hepatic steatosis (HP:0001414)2.86300151
27Mitochondrial inheritance (HP:0001427)2.83044844
28Mediastinal lymphadenopathy (HP:0100721)2.82775601
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.80505174
30Aplasia/Hypoplasia of the sacrum (HP:0008517)2.75863568
31Progressive microcephaly (HP:0000253)2.74335054
32Hepatic necrosis (HP:0002605)2.74021333
33Chronic otitis media (HP:0000389)2.67168600
34Chronic obstructive pulmonary disease (HP:0006510)2.66714249
35Obstructive lung disease (HP:0006536)2.66714249
36Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.64213110
37Recurrent bronchitis (HP:0002837)2.64041102
38Muscle fiber atrophy (HP:0100295)2.61893872
39Increased hepatocellular lipid droplets (HP:0006565)2.61257759
40IgG deficiency (HP:0004315)2.58541042
41Acute necrotizing encephalopathy (HP:0006965)2.56459114
42Type 2 muscle fiber atrophy (HP:0003554)2.53759171
43Respiratory failure (HP:0002878)2.48295211
44Stomatitis (HP:0010280)2.47501236
45Abnormality of the prostate (HP:0008775)2.46179468
46Abnormality of T cell physiology (HP:0011840)2.44629861
47Recurrent fungal infections (HP:0002841)2.43877494
48Optic disc pallor (HP:0000543)2.41702331
49Meningitis (HP:0001287)2.38939585
50Abnormal mitochondria in muscle tissue (HP:0008316)2.38928210
51Increased IgM level (HP:0003496)2.38138482
52Increased CSF lactate (HP:0002490)2.38061431
53Recurrent skin infections (HP:0001581)2.37848031
54Pustule (HP:0200039)2.34304694
55Dicarboxylic aciduria (HP:0003215)2.33355522
56Abnormality of dicarboxylic acid metabolism (HP:0010995)2.33355522
57Abnormal protein glycosylation (HP:0012346)2.32782988
58Abnormal glycosylation (HP:0012345)2.32782988
59Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32782988
60Abnormal protein N-linked glycosylation (HP:0012347)2.32782988
61Poor head control (HP:0002421)2.32279734
6211 pairs of ribs (HP:0000878)2.31452453
63Orchitis (HP:0100796)2.31196369
64Optic neuritis (HP:0100653)2.30912378
65Retrobulbar optic neuritis (HP:0100654)2.30912378
66Methylmalonic aciduria (HP:0012120)2.28346817
67Lipid accumulation in hepatocytes (HP:0006561)2.27765807
68Reduced antithrombin III activity (HP:0001976)2.27184789
69Vasculitis (HP:0002633)2.24801755
70Abnormality of T cells (HP:0002843)2.24131707
71Renal Fanconi syndrome (HP:0001994)2.23344564
72Combined immunodeficiency (HP:0005387)2.22850346
73Lymphoma (HP:0002665)2.22685891
74Increased serum lactate (HP:0002151)2.22446221
75Vacuolated lymphocytes (HP:0001922)2.20201528
76Recurrent viral infections (HP:0004429)2.18864710
77Methylmalonic acidemia (HP:0002912)2.16180942
78Respiratory difficulties (HP:0002880)2.14411814
79Abnormality of cells of the lymphoid lineage (HP:0012140)2.11655603
80Recurrent gram-negative bacterial infections (HP:0005420)2.11042412
81Lymphopenia (HP:0001888)2.09941260
82Prolonged bleeding time (HP:0003010)2.09584320
83Lethargy (HP:0001254)2.09270337
84CNS demyelination (HP:0007305)2.08840329
85Agnosia (HP:0010524)2.08533206
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.08265209
87Abnormality of alanine metabolism (HP:0010916)2.08265209
88Hyperalaninemia (HP:0003348)2.08265209
89Emotional lability (HP:0000712)2.05825951
90Abnormality of renal resorption (HP:0011038)2.05787988
91Abnormality of urine glucose concentration (HP:0011016)2.05775877
92Glycosuria (HP:0003076)2.05775877
93Birth length less than 3rd percentile (HP:0003561)2.04961962
94Nasal polyposis (HP:0100582)2.04433340
95Granulocytopenia (HP:0001913)2.04266535
96Pancytopenia (HP:0001876)2.02488041
97Basal ganglia calcification (HP:0002135)2.00987242
98Increased intramyocellular lipid droplets (HP:0012240)2.00573846
99Generalized aminoaciduria (HP:0002909)2.00418395
100Ketosis (HP:0001946)1.99753202
101Recurrent pneumonia (HP:0006532)1.97951271
102Chromsome breakage (HP:0040012)1.97277391
103Hyperglycinemia (HP:0002154)1.95387130
104Abnormal rod and cone electroretinograms (HP:0008323)1.94785066
105Pancreatic cysts (HP:0001737)1.94391916
106Oral leukoplakia (HP:0002745)1.92551925
107Leukocytosis (HP:0001974)1.92439787
108Abnormality of the renal cortex (HP:0011035)1.92342125
109B lymphocytopenia (HP:0010976)1.92120838
110Abnormality of B cell number (HP:0010975)1.92120838
111Increased serum pyruvate (HP:0003542)1.91194970
112Microretrognathia (HP:0000308)1.90317628
113Medial flaring of the eyebrow (HP:0010747)1.90240703
114Hypergammaglobulinemia (HP:0010702)1.90130990
115Decreased electroretinogram (ERG) amplitude (HP:0000654)1.88392862
116Exercise intolerance (HP:0003546)1.88000410
117Abnormality of the nasal mucosa (HP:0000433)1.87938414
118Absent rod-and cone-mediated responses on ERG (HP:0007688)1.87721012
119Abnormal delayed hypersensitivity skin test (HP:0002963)1.87550442
120Myelodysplasia (HP:0002863)1.87103571
121Recurrent cutaneous fungal infections (HP:0011370)1.86853721
122Chronic mucocutaneous candidiasis (HP:0002728)1.86853721
123Neutropenia (HP:0001875)1.85562678
124Acute encephalopathy (HP:0006846)1.83990165
125Gingivitis (HP:0000230)1.83562215
126Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83329919
127Severe combined immunodeficiency (HP:0004430)1.83317337
128Poikiloderma (HP:0001029)1.82976978
129Bone marrow hypocellularity (HP:0005528)1.82178244
130Hepatosplenomegaly (HP:0001433)1.81648043
131Ketoacidosis (HP:0001993)1.81277745
132Panhypogammaglobulinemia (HP:0003139)1.81199308
133Abolished electroretinogram (ERG) (HP:0000550)1.80373001
134Abnormality of eosinophils (HP:0001879)1.80238139
135Leukodystrophy (HP:0002415)1.80217068
136Prostate neoplasm (HP:0100787)1.77488168
137Congenital stationary night blindness (HP:0007642)1.73666359
138Absent thumb (HP:0009777)1.73538881
139Cleft eyelid (HP:0000625)1.73488079
140Ragged-red muscle fibers (HP:0003200)1.72347433
141Cutaneous photosensitivity (HP:0000992)1.71258775
142Prominent metopic ridge (HP:0005487)1.70266141
143Meckel diverticulum (HP:0002245)1.69898467
144Hypomagnesemia (HP:0002917)1.65877692
145Cerebral hypomyelination (HP:0006808)1.64822434
146Hyperphosphaturia (HP:0003109)1.64205239
147Abnormality of the ileum (HP:0001549)1.63948732
148Aplasia/hypoplasia of the uterus (HP:0008684)1.63745352
149Severe visual impairment (HP:0001141)1.60409445
150Abnormality of glycolysis (HP:0004366)1.59659309
151Abnormality of the preputium (HP:0100587)1.59155995
152Thyroiditis (HP:0100646)1.58893840

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.04742925
2CCNB13.87718234
3NME23.79648975
4BUB13.36524432
5BCKDK3.33879602
6STK162.95091202
7MAP4K12.94080299
8IRAK42.55615532
9NUAK12.53274919
10BLK2.37786043
11PIM22.31835955
12WEE12.17654779
13IRAK32.09610108
14CAMKK22.02350120
15TXK1.95058645
16KDR1.88446073
17EIF2AK11.88169900
18RPS6KA41.87468746
19TEC1.85146842
20TYK21.82601501
21BTK1.79421622
22SRPK11.72527273
23MAP4K21.69418686
24KIT1.69344621
25TBK11.69240566
26TAOK31.68332964
27VRK11.67973837
28MUSK1.67815957
29ACVR1B1.66580314
30TLK11.53235495
31ZAP701.51137833
32WNK41.49470776
33MAP3K121.46880308
34IKBKE1.45636406
35DYRK31.44340213
36JAK31.43926743
37EIF2AK31.43612753
38IKBKB1.42406633
39LIMK11.41411377
40PDK21.30810308
41TESK21.30236919
42PLK41.29944739
43SYK1.21448081
44DAPK11.20366031
45MST41.17686140
46MAP3K141.17300323
47CLK11.17217271
48MYLK1.17195336
49TAF11.16898983
50BRSK21.15802180
51DYRK21.15447404
52ADRBK21.12175575
53TRIM281.03399675
54CSNK1G31.03053408
55CDK191.02686693
56PIM11.02219571
57ARAF1.02141606
58MAP3K111.00518927
59CSF1R1.00517197
60LYN0.98243626
61RIPK40.94258137
62ZAK0.92795749
63CAMK1D0.87126169
64NEK10.86883477
65STK40.86022590
66TGFBR10.84461379
67MAP2K30.83971186
68RPS6KA50.83845705
69FES0.82717268
70NLK0.81972271
71ILK0.81866754
72PASK0.81779397
73CDK70.81447638
74AURKB0.80576783
75PAK40.80495014
76FLT30.79468955
77RPS6KB20.79089350
78FRK0.78496454
79LCK0.76877522
80EIF2AK20.74825560
81BRAF0.74713436
82CSNK1G20.73716145
83MAP2K60.73220135
84TESK10.73156247
85MKNK10.72989665
86STK100.72650311
87NEK20.72034016
88YES10.71636037
89CSNK1G10.71234954
90SIK30.70706890
91ABL20.70315761
92LRRK20.69919387
93PRKCQ0.69596933
94PBK0.69518210
95AURKA0.69417213
96WNK30.65769013
97MAP2K70.65411066
98TIE10.65281964
99BMPR1B0.65039935
100OXSR10.64155184
101PINK10.64003213
102TNK20.63908202
103CDC70.63348870
104MAPKAPK30.63156349
105GRK60.62907037
106ATR0.61870287
107NME10.61081756
108TGFBR20.60949096
109MATK0.58331216
110PLK10.57729009
111CSNK1A1L0.56552210
112INSRR0.55900543
113PLK30.55341084
114CHUK0.54706737
115MAP3K80.53661680
116MAPKAPK20.53660814
117CSNK2A10.53428631
118DAPK30.52602669
119TTK0.52409350
120GRK70.50515054
121ITK0.50125410
122CSK0.49812576
123RPS6KA60.49552173
124PRKG20.48456730
125NEK90.46768252
126GRK50.46691687
127TSSK60.46221249
128GRK10.45941886
129STK240.45786970
130HCK0.45318134
131ERN10.44727090
132PRKCI0.44149014
133RPS6KC10.44036201
134RPS6KL10.44036201
135CSNK2A20.43456337
136MAP2K20.43103296
137PRKCD0.42823393
138CAMK10.40660618
139SCYL20.40444707
140MAPK130.39484608
141MAPKAPK50.35916476
142STK390.34840176
143MAP3K40.30616112
144CHEK20.28419851

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.63792821
2Proteasome_Homo sapiens_hsa030503.69999956
3DNA replication_Homo sapiens_hsa030303.61603355
4RNA polymerase_Homo sapiens_hsa030203.01674585
5Mismatch repair_Homo sapiens_hsa034302.93141743
6Base excision repair_Homo sapiens_hsa034102.67841981
7Homologous recombination_Homo sapiens_hsa034402.55961507
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.45894997
9* Spliceosome_Homo sapiens_hsa030402.38701774
10Pyrimidine metabolism_Homo sapiens_hsa002402.21970007
11Protein export_Homo sapiens_hsa030602.17535972
12Nucleotide excision repair_Homo sapiens_hsa034202.14888680
13Primary immunodeficiency_Homo sapiens_hsa053402.06115403
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.86493049
15Oxidative phosphorylation_Homo sapiens_hsa001901.79316282
16Allograft rejection_Homo sapiens_hsa053301.71997588
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.70171528
18Parkinsons disease_Homo sapiens_hsa050121.69291917
19Basal transcription factors_Homo sapiens_hsa030221.60579189
20Graft-versus-host disease_Homo sapiens_hsa053321.47896825
21Leishmaniasis_Homo sapiens_hsa051401.47090257
22Sulfur metabolism_Homo sapiens_hsa009201.46235873
23RNA degradation_Homo sapiens_hsa030181.46133437
24Fatty acid elongation_Homo sapiens_hsa000621.42019420
25Antigen processing and presentation_Homo sapiens_hsa046121.40343281
26Fanconi anemia pathway_Homo sapiens_hsa034601.39462377
27Herpes simplex infection_Homo sapiens_hsa051681.32179020
28Huntingtons disease_Homo sapiens_hsa050161.31649705
29Measles_Homo sapiens_hsa051621.30695332
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28263520
31Other glycan degradation_Homo sapiens_hsa005111.26574729
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.25815914
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24403077
34RNA transport_Homo sapiens_hsa030131.22927120
35Non-homologous end-joining_Homo sapiens_hsa034501.22816344
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22682583
37Hematopoietic cell lineage_Homo sapiens_hsa046401.22585965
38Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20727246
39Purine metabolism_Homo sapiens_hsa002301.19400491
40Asthma_Homo sapiens_hsa053101.18270344
41Peroxisome_Homo sapiens_hsa041461.17476449
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.17090773
43Cardiac muscle contraction_Homo sapiens_hsa042601.16621541
44Legionellosis_Homo sapiens_hsa051341.15735858
45Cell cycle_Homo sapiens_hsa041101.13797113
46Collecting duct acid secretion_Homo sapiens_hsa049661.12167884
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11345900
48Propanoate metabolism_Homo sapiens_hsa006401.05550156
49Epstein-Barr virus infection_Homo sapiens_hsa051691.04893820
50Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00750588
51p53 signaling pathway_Homo sapiens_hsa041151.00719739
52Alzheimers disease_Homo sapiens_hsa050101.00570159
53Maturity onset diabetes of the young_Homo sapiens_hsa049500.98383270
54Autoimmune thyroid disease_Homo sapiens_hsa053200.97913814
55SNARE interactions in vesicular transport_Homo sapiens_hsa041300.95733415
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.95030134
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94429565
58Phototransduction_Homo sapiens_hsa047440.90394054
59Selenocompound metabolism_Homo sapiens_hsa004500.90013510
60Folate biosynthesis_Homo sapiens_hsa007900.89364336
61Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87575886
62Shigellosis_Homo sapiens_hsa051310.84414624
63Pertussis_Homo sapiens_hsa051330.83927286
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.83140374
65Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.79379106
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79165532
67Butanoate metabolism_Homo sapiens_hsa006500.78302338
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78198105
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.77831552
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.77554461
71Jak-STAT signaling pathway_Homo sapiens_hsa046300.75715705
72Influenza A_Homo sapiens_hsa051640.75503012
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.74433577
74Pyruvate metabolism_Homo sapiens_hsa006200.71944588
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71643975
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.71380261
77Tryptophan metabolism_Homo sapiens_hsa003800.70786046
78Apoptosis_Homo sapiens_hsa042100.70572791
79Systemic lupus erythematosus_Homo sapiens_hsa053220.70046052
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69894462
81Sulfur relay system_Homo sapiens_hsa041220.69765993
82Arachidonic acid metabolism_Homo sapiens_hsa005900.67824531
83Osteoclast differentiation_Homo sapiens_hsa043800.65058344
84Malaria_Homo sapiens_hsa051440.64146746
85B cell receptor signaling pathway_Homo sapiens_hsa046620.62655100
86Caffeine metabolism_Homo sapiens_hsa002320.60087701
87Tuberculosis_Homo sapiens_hsa051520.59886792
88Salmonella infection_Homo sapiens_hsa051320.58476102
89Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57952191
90Viral myocarditis_Homo sapiens_hsa054160.57676514
91Pentose phosphate pathway_Homo sapiens_hsa000300.57099600
92Rheumatoid arthritis_Homo sapiens_hsa053230.56787740
93Type I diabetes mellitus_Homo sapiens_hsa049400.55878343
94N-Glycan biosynthesis_Homo sapiens_hsa005100.55644449
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.53469057
96Viral carcinogenesis_Homo sapiens_hsa052030.51488015
97Hepatitis B_Homo sapiens_hsa051610.50982685
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.48722873
99Galactose metabolism_Homo sapiens_hsa000520.46422456
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.46366087
101Leukocyte transendothelial migration_Homo sapiens_hsa046700.45555200
102Nitrogen metabolism_Homo sapiens_hsa009100.44718837
1032-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44621164
104Lysosome_Homo sapiens_hsa041420.44595504
105Phagosome_Homo sapiens_hsa041450.44208240
106Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43648273
107Carbon metabolism_Homo sapiens_hsa012000.43416226
108One carbon pool by folate_Homo sapiens_hsa006700.43136190
109Acute myeloid leukemia_Homo sapiens_hsa052210.43096388
110Sphingolipid metabolism_Homo sapiens_hsa006000.42997137
111Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41423751
112Glutathione metabolism_Homo sapiens_hsa004800.40880013
113Renin-angiotensin system_Homo sapiens_hsa046140.40379700
114T cell receptor signaling pathway_Homo sapiens_hsa046600.40328655
115mRNA surveillance pathway_Homo sapiens_hsa030150.40112443
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.40075478
117Regulation of autophagy_Homo sapiens_hsa041400.39526523
118Toxoplasmosis_Homo sapiens_hsa051450.39054156
119HTLV-I infection_Homo sapiens_hsa051660.39011335
120Linoleic acid metabolism_Homo sapiens_hsa005910.38428523
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36597719
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.35180814
123TNF signaling pathway_Homo sapiens_hsa046680.34759766
124Drug metabolism - other enzymes_Homo sapiens_hsa009830.34576140
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34258505
126Synaptic vesicle cycle_Homo sapiens_hsa047210.33356661
127Chemical carcinogenesis_Homo sapiens_hsa052040.33004738
128Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31398984
129Vibrio cholerae infection_Homo sapiens_hsa051100.31216596
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31200831
131Metabolic pathways_Homo sapiens_hsa011000.30968500
132Fatty acid degradation_Homo sapiens_hsa000710.30833873
133beta-Alanine metabolism_Homo sapiens_hsa004100.30728190
134Notch signaling pathway_Homo sapiens_hsa043300.28960436
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.27786071
136Staphylococcus aureus infection_Homo sapiens_hsa051500.27428208
137Chemokine signaling pathway_Homo sapiens_hsa040620.26863669
138Pentose and glucuronate interconversions_Homo sapiens_hsa000400.26664550
139Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26337261
140Fatty acid metabolism_Homo sapiens_hsa012120.26224126
141Primary bile acid biosynthesis_Homo sapiens_hsa001200.25583426

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