CC2D2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a coiled-coil and calcium binding domain protein that appears to play a critical role in cilia formation. Mutations in this gene cause Meckel syndrome type 6, as well as Joubert syndrome type 9. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.80778514
2cilium movement (GO:0003341)9.79537889
3epithelial cilium movement (GO:0003351)9.12767793
4motile cilium assembly (GO:0044458)8.08800709
5regulation of cilium movement (GO:0003352)5.34210454
6left/right pattern formation (GO:0060972)5.26593287
7* cilium organization (GO:0044782)5.08604189
8* cilium assembly (GO:0042384)4.95369451
9ventricular system development (GO:0021591)4.55188173
10left/right axis specification (GO:0070986)4.45069051
11protein localization to cilium (GO:0061512)4.32742400
12* cilium morphogenesis (GO:0060271)4.18843342
13microtubule bundle formation (GO:0001578)4.17218329
14* cellular component assembly involved in morphogenesis (GO:0010927)4.03249030
15microtubule-based movement (GO:0007018)3.42225555
16* smoothened signaling pathway (GO:0007224)3.26026117
17regulation of microtubule-based movement (GO:0060632)3.25697473
18cellular potassium ion homeostasis (GO:0030007)3.24511386
19* cell projection assembly (GO:0030031)3.24312123
20determination of left/right symmetry (GO:0007368)3.22521320
21behavioral response to nicotine (GO:0035095)3.17397980
22locomotory exploration behavior (GO:0035641)3.13984314
23determination of bilateral symmetry (GO:0009855)3.08506030
24lateral ventricle development (GO:0021670)3.06129371
25centriole assembly (GO:0098534)3.05005755
26specification of symmetry (GO:0009799)3.02095475
27cell communication by electrical coupling (GO:0010644)3.01287715
28positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.97406840
29neural tube formation (GO:0001841)2.96125829
30membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.95670003
31establishment of tissue polarity (GO:0007164)2.94837094
32establishment of planar polarity (GO:0001736)2.94837094
33cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.93311382
34regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.89475234
35centriole replication (GO:0007099)2.88109443
36sperm motility (GO:0030317)2.87677869
37regulation of short-term neuronal synaptic plasticity (GO:0048172)2.86450883
38one-carbon compound transport (GO:0019755)2.85727672
39nonmotile primary cilium assembly (GO:0035058)2.83732337
40glomerular epithelial cell development (GO:0072310)2.82147024
41primary alcohol catabolic process (GO:0034310)2.79695945
42positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.75771530
43regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.74971508
44protein polyglutamylation (GO:0018095)2.74567494
45limb bud formation (GO:0060174)2.74347580
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.73600535
47cornea development in camera-type eye (GO:0061303)2.73541771
48vitamin transmembrane transport (GO:0035461)2.71870824
49photoreceptor cell maintenance (GO:0045494)2.69769218
50innervation (GO:0060384)2.68853782
51photoreceptor cell development (GO:0042461)2.68006914
52eye photoreceptor cell development (GO:0042462)2.67822499
53retinal rod cell development (GO:0046548)2.67636408
54presynaptic membrane organization (GO:0097090)2.66614672
55microtubule depolymerization (GO:0007019)2.65140086
56positive regulation of smoothened signaling pathway (GO:0045880)2.64182592
57photoreceptor cell differentiation (GO:0046530)2.61966113
58eye photoreceptor cell differentiation (GO:0001754)2.61966113
59spinal cord motor neuron differentiation (GO:0021522)2.59888869
60vocalization behavior (GO:0071625)2.58484132
61regulation of collateral sprouting (GO:0048670)2.57692917
62negative regulation of axon guidance (GO:1902668)2.57256554
63pyrimidine nucleobase catabolic process (GO:0006208)2.57018292
64establishment of nucleus localization (GO:0040023)2.56650523
65neurotransmitter-gated ion channel clustering (GO:0072578)2.54527974
66metanephric mesenchyme development (GO:0072075)2.54385995
67L-amino acid import (GO:0043092)2.54028715
68retinal ganglion cell axon guidance (GO:0031290)2.54016061
69cerebellar Purkinje cell differentiation (GO:0021702)2.53330795
70potassium ion import (GO:0010107)2.53261043
71ovulation cycle (GO:0042698)2.53071519
72positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.52929955
73microtubule polymerization or depolymerization (GO:0031109)2.51950776
74regulation of smoothened signaling pathway (GO:0008589)2.51646512
75detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.50741378
76regulation of membrane repolarization (GO:0060306)2.50624299
77neuronal ion channel clustering (GO:0045161)2.49839753
78establishment of monopolar cell polarity (GO:0061162)2.47813142
79establishment or maintenance of monopolar cell polarity (GO:0061339)2.47813142
80axoneme assembly (GO:0035082)2.47465255
81synaptic vesicle docking involved in exocytosis (GO:0016081)2.46964861
82dendrite morphogenesis (GO:0048813)2.46520107
83presynaptic membrane assembly (GO:0097105)2.46182460
84behavioral response to ethanol (GO:0048149)2.44518742
85axonal fasciculation (GO:0007413)2.44272320
86insulin-like growth factor receptor signaling pathway (GO:0048009)2.43509975
87lateral sprouting from an epithelium (GO:0060601)2.43444491
88diterpenoid biosynthetic process (GO:0016102)2.41972118
89negative regulation of T cell differentiation in thymus (GO:0033085)2.41366935
90lung epithelium development (GO:0060428)2.41267730
91regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.41099912
92endocardial cushion morphogenesis (GO:0003203)2.41012754
93retina layer formation (GO:0010842)2.39990285
94response to pheromone (GO:0019236)2.39964573
95postsynaptic membrane organization (GO:0001941)2.39385676
96dendritic spine morphogenesis (GO:0060997)2.39195117
97somite development (GO:0061053)2.38974680
98mesenchyme morphogenesis (GO:0072132)2.38842682
99atrial cardiac muscle cell action potential (GO:0086014)2.38834193
100regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.38204282
101G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.37758321
102positive regulation of potassium ion transmembrane transport (GO:1901381)2.37278818
103olfactory bulb development (GO:0021772)2.36105477
104nucleoside diphosphate phosphorylation (GO:0006165)2.35833309
105kidney mesenchyme development (GO:0072074)2.34526060
106response to xenobiotic stimulus (GO:0009410)2.33822503
107regulation of vesicle fusion (GO:0031338)2.33729512
108potassium ion homeostasis (GO:0055075)2.33365712
109axon extension involved in axon guidance (GO:0048846)2.32578886
110neuron projection extension involved in neuron projection guidance (GO:1902284)2.32578886
111glutamate receptor signaling pathway (GO:0007215)2.32346543
112glomerulus development (GO:0032835)2.31838280
113positive regulation of vesicle fusion (GO:0031340)2.31746798
114retinal cone cell development (GO:0046549)2.31283891
115terpenoid biosynthetic process (GO:0016114)2.30755232
116sodium ion export (GO:0071436)2.30563926
117negative regulation of sodium ion transport (GO:0010766)2.30191703
118amino acid import (GO:0043090)2.30168400
119regulation of glutamate receptor signaling pathway (GO:1900449)2.29638178
120regulation of rhodopsin mediated signaling pathway (GO:0022400)2.29431033
121negative regulation of cytosolic calcium ion concentration (GO:0051481)2.29139181
122negative regulation of hormone biosynthetic process (GO:0032353)2.28543812
123negative regulation of hormone metabolic process (GO:0032351)2.28543812
124synaptic vesicle exocytosis (GO:0016079)2.28356168
125regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.27599486
126negative regulation of axon extension involved in axon guidance (GO:0048843)2.27035154
127synaptic transmission, glutamatergic (GO:0035249)2.26809094
128regulation of hippo signaling (GO:0035330)2.26424788
129camera-type eye morphogenesis (GO:0048593)2.26120369
130* organelle assembly (GO:0070925)2.25812701
131rhodopsin mediated signaling pathway (GO:0016056)2.25349509
132sequestering of extracellular ligand from receptor (GO:0035581)2.25168576
133positive regulation of potassium ion transport (GO:0043268)2.25162313
134ionotropic glutamate receptor signaling pathway (GO:0035235)2.24906477
135negative regulation of astrocyte differentiation (GO:0048712)2.24352999
136intraciliary transport (GO:0042073)2.24254711
137regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.24151901
138protein localization to synapse (GO:0035418)2.22420324
139fucose catabolic process (GO:0019317)2.22094781
140L-fucose metabolic process (GO:0042354)2.22094781
141L-fucose catabolic process (GO:0042355)2.22094781
142cytoplasmic microtubule organization (GO:0031122)2.22082336
143regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.21291632
144nucleus localization (GO:0051647)2.21220402
145cerebellar granule cell differentiation (GO:0021707)2.21032323
146retinoic acid metabolic process (GO:0042573)2.21016051
147neuron cell-cell adhesion (GO:0007158)2.20595031
148relaxation of cardiac muscle (GO:0055119)2.20057750
149neuromuscular junction development (GO:0007528)2.20052027
150head development (GO:0060322)2.19716788
151synaptic vesicle maturation (GO:0016188)2.19302916
152neuron recognition (GO:0008038)2.18876165
153microtubule-based process (GO:0007017)2.18850116
154central nervous system neuron axonogenesis (GO:0021955)2.18418138
155inner ear receptor stereocilium organization (GO:0060122)2.18213561
156dendritic spine organization (GO:0097061)2.17132545
157neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.16986467
158regulation of potassium ion transmembrane transport (GO:1901379)2.16896699
159myelination in peripheral nervous system (GO:0022011)2.16455068
160peripheral nervous system axon ensheathment (GO:0032292)2.16455068
161establishment of apical/basal cell polarity (GO:0035089)2.16214711
162limb development (GO:0060173)2.16003007
163appendage development (GO:0048736)2.16003007
164positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.15829148
165inner ear receptor cell development (GO:0060119)2.15745820
166exploration behavior (GO:0035640)2.15427283
167positive regulation of glycogen biosynthetic process (GO:0045725)2.15126664
168gonadal mesoderm development (GO:0007506)2.14661893
169neuronal stem cell maintenance (GO:0097150)2.14103110
170cellular response to cholesterol (GO:0071397)2.13893179
171auditory behavior (GO:0031223)2.13380087
172regulation of non-canonical Wnt signaling pathway (GO:2000050)2.13304033
173mechanosensory behavior (GO:0007638)2.13021913
174layer formation in cerebral cortex (GO:0021819)2.12863912
175glutamate secretion (GO:0014047)2.12786236
176central nervous system projection neuron axonogenesis (GO:0021952)2.11996628
177ethanol metabolic process (GO:0006067)2.11689348
178renal tubule morphogenesis (GO:0061333)2.11516846
179cerebral cortex radially oriented cell migration (GO:0021799)2.10888514
180axonemal dynein complex assembly (GO:0070286)11.4363410
181cilium or flagellum-dependent cell motility (GO:0001539)10.3926603

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.50837832
2EZH2_22144423_ChIP-Seq_EOC_Human2.86545484
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75647102
4VDR_22108803_ChIP-Seq_LS180_Human2.71441121
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52995010
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.49459719
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.43582130
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.42384107
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35029491
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.23543903
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.23543903
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19514231
13IGF1R_20145208_ChIP-Seq_DFB_Human2.16789358
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.15493230
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14246957
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.14042682
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.10493315
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.10240836
19AR_21572438_ChIP-Seq_LNCaP_Human1.96846111
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90266605
21EWS_26573619_Chip-Seq_HEK293_Human1.90120122
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.85891950
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.84802121
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83126865
25PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.80096118
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.79197424
27DROSHA_22980978_ChIP-Seq_HELA_Human1.77676068
28SMAD4_21799915_ChIP-Seq_A2780_Human1.73001203
29SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72947072
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.72787302
31PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.68664114
32ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.65592568
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65338795
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64203700
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.63697210
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62544286
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.61549450
38EZH2_27294783_Chip-Seq_ESCs_Mouse1.60015932
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.56607975
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.55962242
41PCGF2_27294783_Chip-Seq_ESCs_Mouse1.55862813
42P300_19829295_ChIP-Seq_ESCs_Human1.55753588
43ER_23166858_ChIP-Seq_MCF-7_Human1.55238634
44HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51780041
45EP300_21415370_ChIP-Seq_HL-1_Mouse1.51609976
46ARNT_22903824_ChIP-Seq_MCF-7_Human1.50404157
47SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50143238
48AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.48750781
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48606993
50CBP_20019798_ChIP-Seq_JUKART_Human1.48023779
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.48023779
52FUS_26573619_Chip-Seq_HEK293_Human1.47537601
53AHR_22903824_ChIP-Seq_MCF-7_Human1.46496491
54SALL1_21062744_ChIP-ChIP_HESCs_Human1.44969588
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.44835664
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44773671
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44110296
58TP53_16413492_ChIP-PET_HCT116_Human1.43294687
59CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41725463
60FOXM1_26456572_ChIP-Seq_MCF-7_Human1.41200020
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.40423248
62SMAD_19615063_ChIP-ChIP_OVARY_Human1.40076205
63FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.39312747
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.39295501
65STAT3_23295773_ChIP-Seq_U87_Human1.38990426
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37810748
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36687018
68BCAT_22108803_ChIP-Seq_LS180_Human1.36394665
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.33544267
70NR3C1_21868756_ChIP-Seq_MCF10A_Human1.33254952
71TCF4_22108803_ChIP-Seq_LS180_Human1.33148456
72TP53_18474530_ChIP-ChIP_U2OS_Human1.27253253
73WT1_25993318_ChIP-Seq_PODOCYTE_Human1.26659126
74AR_19668381_ChIP-Seq_PC3_Human1.25656033
75NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24264796
76EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23989145
77SOX2_21211035_ChIP-Seq_LN229_Gbm1.23461716
78RNF2_27304074_Chip-Seq_NSC_Mouse1.22044690
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21833676
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.20904365
81SMAD4_21741376_ChIP-Seq_EPCs_Human1.20838488
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20505372
83AR_25329375_ChIP-Seq_VCAP_Human1.20485503
84FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19267044
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19123013
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19123013
87EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19106491
88MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18931663
89REST_21632747_ChIP-Seq_MESCs_Mouse1.18226175
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.17514861
91EZH2_27294783_Chip-Seq_NPCs_Mouse1.17225243
92YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17037515
93TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.16955393
94TCF4_23295773_ChIP-Seq_U87_Human1.16855101
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15938816
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14933492
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14899323
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.14480811
99TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13842304
100RXR_22108803_ChIP-Seq_LS180_Human1.11461672
101NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11421917
102NFE2_27457419_Chip-Seq_LIVER_Mouse1.11281014
103RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10944019
104RING1B_27294783_Chip-Seq_NPCs_Mouse1.10597550
105P53_22387025_ChIP-Seq_ESCs_Mouse1.10429340
106RARB_27405468_Chip-Seq_BRAIN_Mouse1.10158685
107CJUN_26792858_Chip-Seq_BT549_Human1.10060827
108ISL1_27105846_Chip-Seq_CPCs_Mouse1.09993746
109BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09861008
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08683950
111* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.08296986
112TAF15_26573619_Chip-Seq_HEK293_Human1.08254195
113JUN_21703547_ChIP-Seq_K562_Human1.07358205
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06590229
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06469033
116TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06469033
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.06451074
118RUNX2_22187159_ChIP-Seq_PCA_Human1.06373957
119E2F1_18555785_Chip-Seq_ESCs_Mouse1.05980782
120WT1_19549856_ChIP-ChIP_CCG9911_Human1.05308975
121NANOG_18555785_Chip-Seq_ESCs_Mouse1.05249856
122TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05218134
123PRDM14_20953172_ChIP-Seq_ESCs_Human1.04659683
124SMAD4_21741376_ChIP-Seq_HESCs_Human1.04225972
125TBL1_22424771_ChIP-Seq_293T_Human1.04170082
126ZNF274_21170338_ChIP-Seq_K562_Hela1.04161946
127WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04064815
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04064664
129LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03660486
130UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02311357
131SMAD3_21741376_ChIP-Seq_HESCs_Human1.01864525
132SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.00997316
133* CDX2_22108803_ChIP-Seq_LS180_Human1.00713881
134FLI1_21867929_ChIP-Seq_TH2_Mouse1.00277197
135CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99985093
136POU5F1_16153702_ChIP-ChIP_HESCs_Human0.99227341
137SOX2_19829295_ChIP-Seq_ESCs_Human0.98777644
138NANOG_19829295_ChIP-Seq_ESCs_Human0.98777644

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.67737210
2MP0000569_abnormal_digit_pigmentation2.79561581
3MP0006072_abnormal_retinal_apoptosis2.46311109
4MP0005551_abnormal_eye_electrophysiolog2.45495671
5MP0002102_abnormal_ear_morphology2.37535932
6MP0003283_abnormal_digestive_organ2.35622311
7MP0004859_abnormal_synaptic_plasticity2.16840528
8MP0000566_synostosis2.15707414
9MP0008875_abnormal_xenobiotic_pharmacok2.15404595
10MP0003122_maternal_imprinting2.12982185
11MP0009780_abnormal_chondrocyte_physiolo2.07083430
12MP0005171_absent_coat_pigmentation2.07006115
13MP0005503_abnormal_tendon_morphology1.93030604
14MP0005253_abnormal_eye_physiology1.89775952
15MP0010030_abnormal_orbit_morphology1.86242516
16MP0003878_abnormal_ear_physiology1.82145834
17MP0005377_hearing/vestibular/ear_phenot1.82145834
18MP0003950_abnormal_plasma_membrane1.75864754
19MP0001486_abnormal_startle_reflex1.70000435
20MP0003136_yellow_coat_color1.68422413
21MP0004270_analgesia1.68274453
22MP0003635_abnormal_synaptic_transmissio1.66942976
23MP0002282_abnormal_trachea_morphology1.63417423
24MP0000383_abnormal_hair_follicle1.62158635
25MP0002938_white_spotting1.60693054
26MP0008438_abnormal_cutaneous_collagen1.60052616
27MP0001299_abnormal_eye_distance/1.59828356
28MP0009384_cardiac_valve_regurgitation1.57682280
29MP0001485_abnormal_pinna_reflex1.53259396
30MP0004272_abnormal_basement_membrane1.52910008
31MP0005646_abnormal_pituitary_gland1.50542434
32MP0004145_abnormal_muscle_electrophysio1.47566109
33MP0001984_abnormal_olfaction1.47514589
34MP0001293_anophthalmia1.47433243
35MP0000778_abnormal_nervous_system1.44938000
36MP0002249_abnormal_larynx_morphology1.44903385
37MP0003942_abnormal_urinary_system1.39068258
38MP0001502_abnormal_circadian_rhythm1.36787760
39MP0006276_abnormal_autonomic_nervous1.36233568
40MP0004233_abnormal_muscle_weight1.35655700
41MP0002638_abnormal_pupillary_reflex1.34716060
42MP0004215_abnormal_myocardial_fiber1.34683156
43MP0005670_abnormal_white_adipose1.34531872
44MP0003890_abnormal_embryonic-extraembry1.31793378
45MP0009250_abnormal_appendicular_skeleto1.31306716
46MP0000049_abnormal_middle_ear1.31186139
47MP0004858_abnormal_nervous_system1.31033728
48MP0000427_abnormal_hair_cycle1.30765232
49MP0006292_abnormal_olfactory_placode1.29378183
50MP0005187_abnormal_penis_morphology1.27673142
51MP0000751_myopathy1.27492225
52MP0002108_abnormal_muscle_morphology1.26971666
53MP0003385_abnormal_body_wall1.26001272
54MP0001879_abnormal_lymphatic_vessel1.25933295
55MP0000013_abnormal_adipose_tissue1.25724332
56MP0003195_calcinosis1.25016555
57MP0004885_abnormal_endolymph1.24789495
58MP0008877_abnormal_DNA_methylation1.24323075
59MP0003880_abnormal_central_pattern1.24165532
60MP0000026_abnormal_inner_ear1.23796301
61MP0000428_abnormal_craniofacial_morphol1.22219889
62MP0000534_abnormal_ureter_morphology1.20823817
63MP0005257_abnormal_intraocular_pressure1.20735810
64MP0002063_abnormal_learning/memory/cond1.18749269
65MP0005623_abnormal_meninges_morphology1.15819203
66MP0002277_abnormal_respiratory_mucosa1.15008653
67MP0005499_abnormal_olfactory_system1.15000394
68MP0005394_taste/olfaction_phenotype1.15000394
69MP0009046_muscle_twitch1.14847222
70MP0008789_abnormal_olfactory_epithelium1.13999178
71MP0002160_abnormal_reproductive_system1.12931140
72MP0005195_abnormal_posterior_eye1.11968473
73MP0001958_emphysema1.11167725
74MP0005391_vision/eye_phenotype1.10863340
75MP0002233_abnormal_nose_morphology1.10209119
76MP0003937_abnormal_limbs/digits/tail_de1.10063872
77MP0002734_abnormal_mechanical_nocicepti1.09770948
78MP0002572_abnormal_emotion/affect_behav1.09715492
79MP0002928_abnormal_bile_duct1.09098085
80MP0009745_abnormal_behavioral_response1.09035450
81MP0002064_seizures1.08839253
82MP0010368_abnormal_lymphatic_system1.08790104
83MP0005423_abnormal_somatic_nervous1.08073144
84MP0002272_abnormal_nervous_system1.07895781
85MP0004142_abnormal_muscle_tone1.06809724
86MP0002557_abnormal_social/conspecific_i1.05783198
87MP0003119_abnormal_digestive_system1.05583909
88MP0002882_abnormal_neuron_morphology1.04922689
89MP0002234_abnormal_pharynx_morphology1.04531159
90MP0010386_abnormal_urinary_bladder1.03994696
91MP0005248_abnormal_Harderian_gland1.03627200
92MP0001529_abnormal_vocalization1.03340322
93MP0001177_atelectasis1.03311034
94MP0003279_aneurysm1.02580911
95MP0002751_abnormal_autonomic_nervous1.02550254
96MP0003115_abnormal_respiratory_system1.02258257
97MP0001501_abnormal_sleep_pattern1.01632925
98MP0000631_abnormal_neuroendocrine_gland1.01570162
99MP0002067_abnormal_sensory_capabilities1.01068019
100MP0001324_abnormal_eye_pigmentation1.00267997
101MP0005508_abnormal_skeleton_morphology0.99096588
102MP0003011_delayed_dark_adaptation0.97419092
103MP0003755_abnormal_palate_morphology0.97279507
104MP0003941_abnormal_skin_development0.96078492
105MP0002837_dystrophic_cardiac_calcinosis0.95704403
106MP0010678_abnormal_skin_adnexa0.95463211
107MP0004133_heterotaxia0.95446530
108MP0002116_abnormal_craniofacial_bone0.93595152
109MP0002876_abnormal_thyroid_physiology0.93100265
110MP0002736_abnormal_nociception_after0.92950322
111MP0002184_abnormal_innervation0.92556249
112MP0002909_abnormal_adrenal_gland0.91950604
113MP0000955_abnormal_spinal_cord0.91898589
114MP0002254_reproductive_system_inflammat0.91765228
115MP0002752_abnormal_somatic_nervous0.91652053
116MP0001440_abnormal_grooming_behavior0.91601968
117MP0003045_fibrosis0.91531887
118MP0009053_abnormal_anal_canal0.91195258
119MP0001286_abnormal_eye_development0.91125061
120MP0005174_abnormal_tail_pigmentation0.90894028
121MP0001968_abnormal_touch/_nociception0.90838875
122MP0003787_abnormal_imprinting0.90712866
123MP0003861_abnormal_nervous_system0.89010161
124MP0002090_abnormal_vision0.88611281
125MP0003634_abnormal_glial_cell0.87828519
126MP0003935_abnormal_craniofacial_develop0.87696486
127MP0003121_genomic_imprinting0.85622453
128MP0000678_abnormal_parathyroid_gland0.85362123
129MP0002735_abnormal_chemical_nociception0.84176834
130MP0008569_lethality_at_weaning0.84153015
131MP0004043_abnormal_pH_regulation0.83857100
132MP0001963_abnormal_hearing_physiology0.83565772
133MP0005645_abnormal_hypothalamus_physiol0.82772998
134MP0000537_abnormal_urethra_morphology0.82378431
135MP0002168_other_aberrant_phenotype0.81998366
136MP0000647_abnormal_sebaceous_gland0.81988057
137MP0002109_abnormal_limb_morphology0.81228758
138MP0000372_irregular_coat_pigmentation0.79149717
139MP0002152_abnormal_brain_morphology0.77682613

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.81439486
2Dynein arm defect of respiratory motile cilia (HP:0012255)8.34955615
3Absent/shortened dynein arms (HP:0200106)8.34955615
4Abnormal respiratory epithelium morphology (HP:0012253)8.26146656
5Abnormal respiratory motile cilium morphology (HP:0005938)8.26146656
6Rhinitis (HP:0012384)7.22141926
7Chronic bronchitis (HP:0004469)5.27456727
8Bronchiectasis (HP:0002110)4.86400108
9* True hermaphroditism (HP:0010459)4.20299575
10* Pancreatic cysts (HP:0001737)3.90240458
11* Nephronophthisis (HP:0000090)3.83005806
12* Abnormality of midbrain morphology (HP:0002418)3.79440567
13* Molar tooth sign on MRI (HP:0002419)3.79440567
14Aplasia of the phalanges of the hand (HP:0009802)3.73114309
15Aplasia involving bones of the extremities (HP:0009825)3.73114309
16Aplasia involving bones of the upper limbs (HP:0009823)3.73114309
17Nasal polyposis (HP:0100582)3.58981858
18* Abnormality of the renal medulla (HP:0100957)3.28235255
19Chorioretinal atrophy (HP:0000533)3.18891243
20* Cystic liver disease (HP:0006706)3.09735642
21Congenital stationary night blindness (HP:0007642)3.07406682
22* Occipital encephalocele (HP:0002085)3.04298872
23Central scotoma (HP:0000603)2.96806757
24Scotoma (HP:0000575)2.95367109
25* Postaxial foot polydactyly (HP:0001830)2.90947228
26Tubular atrophy (HP:0000092)2.83543724
27Abnormality of the nasal mucosa (HP:0000433)2.76819442
28* Aplasia/Hypoplasia of the tongue (HP:0010295)2.73938844
29Bony spicule pigmentary retinopathy (HP:0007737)2.67937968
30Chronic sinusitis (HP:0011109)2.63718511
31Infertility (HP:0000789)2.63441321
32* Congenital hepatic fibrosis (HP:0002612)2.62549357
33Broad metatarsal (HP:0001783)2.58416618
34Bronchitis (HP:0012387)2.57916216
35Focal motor seizures (HP:0011153)2.55213773
36* Chronic hepatic failure (HP:0100626)2.53467816
37Tubulointerstitial nephritis (HP:0001970)2.53165844
38* Anencephaly (HP:0002323)2.50721078
39Megalencephaly (HP:0001355)2.46958512
40Epileptic encephalopathy (HP:0200134)2.45139027
41* Postaxial hand polydactyly (HP:0001162)2.43936179
42Abnormality of the renal cortex (HP:0011035)2.31292229
43* Sclerocornea (HP:0000647)2.30285494
44Cutaneous finger syndactyly (HP:0010554)2.30218883
45Abnormality of dentin (HP:0010299)2.25930058
46Pigmentary retinal degeneration (HP:0001146)2.25461602
47Abnormal ciliary motility (HP:0012262)2.18996990
48Cutaneous syndactyly (HP:0012725)2.18763406
49Poor coordination (HP:0002370)2.15966889
50Abnormality of macular pigmentation (HP:0008002)2.14601017
51Action tremor (HP:0002345)2.13836785
52Recurrent sinusitis (HP:0011108)2.12338803
53* Preaxial hand polydactyly (HP:0001177)2.07438138
54* Male pseudohermaphroditism (HP:0000037)2.05762622
55Bell-shaped thorax (HP:0001591)2.05128049
56Tubulointerstitial abnormality (HP:0001969)2.04315327
57Bronchomalacia (HP:0002780)2.01756822
58Humeroradial synostosis (HP:0003041)1.97083142
59Synostosis involving the elbow (HP:0003938)1.97083142
60Hypoplastic left heart (HP:0004383)1.96484558
61Progressive cerebellar ataxia (HP:0002073)1.96191498
62Neonatal short-limb short stature (HP:0008921)1.95224909
63Prolonged QT interval (HP:0001657)1.94652815
64Congenital sensorineural hearing impairment (HP:0008527)1.94240795
65Follicular hyperkeratosis (HP:0007502)1.93082218
66Macroorchidism (HP:0000053)1.92683685
67Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.92239510
68Hyperventilation (HP:0002883)1.90646165
69Abnormal respiratory motile cilium physiology (HP:0012261)1.89924577
70Midline defect of the nose (HP:0004122)1.89740609
71Hepatoblastoma (HP:0002884)1.89247645
72* Furrowed tongue (HP:0000221)1.87694252
73Polydipsia (HP:0001959)1.87181950
74Abnormal drinking behavior (HP:0030082)1.87181950
75Type II lissencephaly (HP:0007260)1.86981032
76Gait imbalance (HP:0002141)1.85034680
77Febrile seizures (HP:0002373)1.84502033
78Keratoconus (HP:0000563)1.82843743
79Increased corneal curvature (HP:0100692)1.82843743
80Congenital primary aphakia (HP:0007707)1.82675389
81Ectopic anus (HP:0004397)1.82393836
82Genetic anticipation (HP:0003743)1.82208445
83Short hallux (HP:0010109)1.78679131
84Fibular aplasia (HP:0002990)1.78331838
85Supernumerary spleens (HP:0009799)1.78265767
86Median cleft lip (HP:0000161)1.77955796
87Genital tract atresia (HP:0001827)1.77899383
88Dyschromatopsia (HP:0007641)1.76026922
89Vaginal atresia (HP:0000148)1.74917580
90Focal seizures (HP:0007359)1.74816268
91Blue irides (HP:0000635)1.73625283
92Aplasia/Hypoplasia of the fibula (HP:0006492)1.73165616
93Stage 5 chronic kidney disease (HP:0003774)1.72823249
94Male infertility (HP:0003251)1.72445418
95Overgrowth (HP:0001548)1.71874828
96Hypoplastic labia majora (HP:0000059)1.71573189
97* Narrow forehead (HP:0000341)1.71449352
98Narrow nasal bridge (HP:0000446)1.70832461
99Anophthalmia (HP:0000528)1.70830599
100Hyperactive renin-angiotensin system (HP:0000841)1.70633890
101Abnormality of the middle phalanges of the toes (HP:0010183)1.70595293
102Coronal craniosynostosis (HP:0004440)1.69658864
103Atrial fibrillation (HP:0005110)1.69301518
104Aplasia/Hypoplasia of the spleen (HP:0010451)1.68640116
105* Oculomotor apraxia (HP:0000657)1.68639728
106Aplasia/Hypoplasia of the lens (HP:0008063)1.67443671
107Dysdiadochokinesis (HP:0002075)1.67158264
108Bifid tongue (HP:0010297)1.66774553
109Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.66768663
110Abnormal rod and cone electroretinograms (HP:0008323)1.66308708
111Shallow orbits (HP:0000586)1.65634478
112Medial flaring of the eyebrow (HP:0010747)1.65108682
113Absent rod-and cone-mediated responses on ERG (HP:0007688)1.65086747
114Decreased circulating renin level (HP:0003351)1.64722014
115Tubulointerstitial fibrosis (HP:0005576)1.64624691
116Recurrent otitis media (HP:0000403)1.64599519
117Trigonocephaly (HP:0000243)1.64544834
118Hemiparesis (HP:0001269)1.63616884
119Absent speech (HP:0001344)1.63204174
120Morphological abnormality of the middle ear (HP:0008609)1.63119279
121Abnormality of the fovea (HP:0000493)1.62661811
122Long nose (HP:0003189)1.62500171
123Broad foot (HP:0001769)1.62335822
124Cerebellar dysplasia (HP:0007033)1.61200318
125Nephrogenic diabetes insipidus (HP:0009806)1.59669959
126Buphthalmos (HP:0000557)1.57706450
127Specific learning disability (HP:0001328)1.57447201
128Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.56900934
129Asplenia (HP:0001746)1.56682956
130Primary atrial arrhythmia (HP:0001692)1.56635438
131Absent frontal sinuses (HP:0002688)1.56591655
132Atonic seizures (HP:0010819)1.56063122
133Renal dysplasia (HP:0000110)1.56001347
134Decreased central vision (HP:0007663)1.55160864
135Abnormality of incisor morphology (HP:0011063)1.54847214
136Type II diabetes mellitus (HP:0005978)1.54811483
137Synostosis involving bones of the feet (HP:0009140)1.53583523
138Synostosis involving bones of the lower limbs (HP:0009138)1.53583523
139Intestinal atresia (HP:0011100)1.53483096
140Hypoplastic ischia (HP:0003175)1.53056829
141* Pancreatic fibrosis (HP:0100732)1.52838792
142Syncope (HP:0001279)1.52548972
143Hypoventilation (HP:0002791)1.52295125
144Aplasia/Hypoplasia of the fovea (HP:0008060)1.51904470
145Hypoplasia of the fovea (HP:0007750)1.51904470
146Abnormality of the labia majora (HP:0012881)1.51836920
147Aplasia/Hypoplasia of the tibia (HP:0005772)1.50852428
148Omphalocele (HP:0001539)1.50377959
149Aplasia/Hypoplasia of the hallux (HP:0008362)1.49924350
150Broad toe (HP:0001837)1.49351617
151Labial hypoplasia (HP:0000066)1.49250379
152Tarsal synostosis (HP:0008368)1.48919303
153Alacrima (HP:0000522)1.48433557
154Short foot (HP:0001773)1.48151212
155Anteriorly placed anus (HP:0001545)1.48083530
156Enlarged penis (HP:0000040)1.48054935
157Abolished electroretinogram (ERG) (HP:0000550)1.47157636
158Abnormality of the nasolacrimal system (HP:0000614)1.46924885
159Abnormal EKG (HP:0003115)1.46788636
160Potter facies (HP:0002009)1.46265508
161Facial shape deformation (HP:0011334)1.46265508
162Exercise-induced myalgia (HP:0003738)1.46182570
163* Prominent nasal bridge (HP:0000426)1.44091172
164Oligodactyly (hands) (HP:0001180)1.43812152
165Gaze-evoked nystagmus (HP:0000640)1.42979761
166Fibular hypoplasia (HP:0003038)1.41216828
167Polyuria (HP:0000103)1.41146030
168Chronic otitis media (HP:0000389)1.40732681
169* Multicystic kidney dysplasia (HP:0000003)1.40481655
170* Aganglionic megacolon (HP:0002251)1.39818820
171Hyperaldosteronism (HP:0000859)1.38870099
172* Highly arched eyebrow (HP:0002553)1.37950025
173Gastrointestinal atresia (HP:0002589)1.37816877
174* Dandy-Walker malformation (HP:0001305)1.35583298
175Micropenis (HP:0000054)1.34801590

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK3.41670190
2NTRK33.09675286
3INSRR2.54703754
4LATS12.52959986
5EPHA42.51944196
6CASK2.42702453
7MKNK22.42376380
8BMPR1B2.38137398
9PRKD32.25199262
10MST42.14392532
11SIK12.00815475
12PHKG21.87983909
13PHKG11.87983909
14EPHA31.66888111
15FRK1.66464691
16PDGFRA1.64163747
17SGK21.62239994
18MAPK131.56461206
19MAP4K21.54195305
20DDR21.52805647
21NTRK21.51020182
22BRSK21.48900632
23ACVR1B1.47794168
24ADRBK21.47478445
25LMTK21.42531402
26SGK2231.37211610
27SGK4941.37211610
28MAP3K41.34653144
29BRD41.32721309
30SGK31.30868024
31FGFR21.29395644
32CDC42BPA1.29188434
33TRIM281.28392463
34PRKD21.24971498
35KSR11.24693811
36MAPK151.22530543
37PAK31.22523302
38MKNK11.21609194
39NUAK11.20922338
40CAMK1G1.19509839
41WNK11.19017963
42PIK3CA1.17979309
43NTRK11.16562126
44PRKCH1.15161383
45WNK31.14375233
46MAP2K71.13065904
47RIPK11.12722642
48MUSK1.12624501
49ERBB31.11456991
50PRPF4B1.10812260
51DMPK1.09323386
52PRKCE1.08384809
53GRK11.08028627
54MAP3K21.07981823
55AKT31.07927900
56PLK21.07214795
57STK391.05949675
58CAMK1D1.03840220
59FER1.02871171
60IRAK11.00990756
61CDK30.98943619
62PAK60.96843513
63OXSR10.96835049
64SGK10.94377886
65PRKCG0.92667573
66SIK30.91560630
67DYRK20.87399082
68NEK60.85956433
69CAMKK20.84907674
70TGFBR10.83586105
71BCR0.83373445
72CSNK1G20.81443279
73MINK10.80394000
74TIE10.77392959
75NME10.76170804
76TRIB30.75952028
77NLK0.74638176
78STK30.73854385
79MARK10.73441475
80ADRBK10.73114918
81PNCK0.72227806
82HIPK20.71368951
83TLK10.71326549
84WNK40.70061169
85CAMK2A0.69591625
86MAP3K60.69369761
87STK38L0.68920695
88CSNK1G10.68804506
89OBSCN0.66852898
90ROCK10.66494239
91PTK60.66454162
92CAMK2D0.66321513
93UHMK10.65744428
94PRKAA20.64896902
95PTK2B0.64594985
96WEE10.64502418
97EPHA20.62959792
98PLK30.61930166
99CDK50.61893426
100STK380.61405013
101ERBB20.61260622
102PDGFRB0.60008782
103TRPM70.59123549
104FGFR10.58875054
105DYRK1A0.58764918
106LATS20.58507161
107PTK20.57653114
108PRKG10.57084088
109RPS6KA30.55633548
110MYLK0.54892516
111EPHB20.54792618
112BMX0.54306503
113PINK10.54165791
114MAPK70.53371464
115MAP2K40.53054739
116PBK0.52552966
117DAPK20.52143576
118CSNK1G30.51424701
119STK110.50061368
120CSNK1A1L0.50034184
121MET0.49564723
122MAPKAPK30.49386410
123PLK40.48908774
124YES10.48797742
125PKN10.48640664
126DYRK30.45088407
127MAPK100.44488066
128VRK10.44281309
129ZAK0.43508595
130PRKAA10.43369210
131CAMK40.41942353
132GSK3B0.41818350
133PRKACA0.41510120
134TSSK60.39870577
135PLK10.38087314
136CDK80.37196578
137TTK0.34247531
138PRKCZ0.31288682
139STK240.30838899
140ERBB40.30831747

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047443.52704359
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.42142324
3Nicotine addiction_Homo sapiens_hsa050332.37852890
4Insulin secretion_Homo sapiens_hsa049112.26752612
5Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.25712585
6Chemical carcinogenesis_Homo sapiens_hsa052042.23480696
7Circadian entrainment_Homo sapiens_hsa047132.15656140
8GABAergic synapse_Homo sapiens_hsa047272.07297189
9Huntingtons disease_Homo sapiens_hsa050162.03964580
10Histidine metabolism_Homo sapiens_hsa003402.00028812
11Glutamatergic synapse_Homo sapiens_hsa047241.95935538
12beta-Alanine metabolism_Homo sapiens_hsa004101.84518068
13Linoleic acid metabolism_Homo sapiens_hsa005911.83738193
14Olfactory transduction_Homo sapiens_hsa047401.80764279
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.79948028
16Morphine addiction_Homo sapiens_hsa050321.78092912
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.77548818
18Dilated cardiomyopathy_Homo sapiens_hsa054141.76103303
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.70833361
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.69787771
21Nitrogen metabolism_Homo sapiens_hsa009101.64958317
22Amphetamine addiction_Homo sapiens_hsa050311.63116183
23Salivary secretion_Homo sapiens_hsa049701.63014247
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.60890001
25Gastric acid secretion_Homo sapiens_hsa049711.57602672
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.56166145
27Renin secretion_Homo sapiens_hsa049241.56028279
28Propanoate metabolism_Homo sapiens_hsa006401.53370477
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.50824432
30Circadian rhythm_Homo sapiens_hsa047101.49645535
31ABC transporters_Homo sapiens_hsa020101.49462227
32Retinol metabolism_Homo sapiens_hsa008301.47878847
33Aldosterone synthesis and secretion_Homo sapiens_hsa049251.44697775
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.43028686
35Long-term potentiation_Homo sapiens_hsa047201.42819774
36Taste transduction_Homo sapiens_hsa047421.42408117
37Cholinergic synapse_Homo sapiens_hsa047251.40699741
38Cocaine addiction_Homo sapiens_hsa050301.40282434
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38152311
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.37221775
41Tyrosine metabolism_Homo sapiens_hsa003501.36260669
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32959186
43Tryptophan metabolism_Homo sapiens_hsa003801.32131252
44Caffeine metabolism_Homo sapiens_hsa002321.31524287
45Dopaminergic synapse_Homo sapiens_hsa047281.31040514
46Calcium signaling pathway_Homo sapiens_hsa040201.30506998
47cGMP-PKG signaling pathway_Homo sapiens_hsa040221.30504454
48cAMP signaling pathway_Homo sapiens_hsa040241.29484759
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.29337299
50Basal cell carcinoma_Homo sapiens_hsa052171.29001871
51Type II diabetes mellitus_Homo sapiens_hsa049301.28316702
52Melanogenesis_Homo sapiens_hsa049161.27402106
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26448558
54Synaptic vesicle cycle_Homo sapiens_hsa047211.25473701
55Hedgehog signaling pathway_Homo sapiens_hsa043401.23913758
56Steroid hormone biosynthesis_Homo sapiens_hsa001401.21846988
57Serotonergic synapse_Homo sapiens_hsa047261.21121099
58alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20880368
59Oxytocin signaling pathway_Homo sapiens_hsa049211.20843136
60Maturity onset diabetes of the young_Homo sapiens_hsa049501.18809769
61Protein export_Homo sapiens_hsa030601.18732473
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14571038
63ECM-receptor interaction_Homo sapiens_hsa045121.13581948
64Fatty acid biosynthesis_Homo sapiens_hsa000611.12934217
65Steroid biosynthesis_Homo sapiens_hsa001001.12431124
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.12277711
67Axon guidance_Homo sapiens_hsa043601.11667834
68Peroxisome_Homo sapiens_hsa041461.11541706
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11146756
70Dorso-ventral axis formation_Homo sapiens_hsa043201.10560206
71Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09913025
72Basal transcription factors_Homo sapiens_hsa030221.09224341
73Gap junction_Homo sapiens_hsa045401.09081481
74Phenylalanine metabolism_Homo sapiens_hsa003601.08822886
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.05963339
76Vascular smooth muscle contraction_Homo sapiens_hsa042701.02524246
77Glucagon signaling pathway_Homo sapiens_hsa049221.02066836
78Long-term depression_Homo sapiens_hsa047301.00941555
79Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98620144
80GnRH signaling pathway_Homo sapiens_hsa049120.98610155
81RNA polymerase_Homo sapiens_hsa030200.98107766
82Thyroid hormone synthesis_Homo sapiens_hsa049180.98091425
83Oxidative phosphorylation_Homo sapiens_hsa001900.97391366
84Ovarian steroidogenesis_Homo sapiens_hsa049130.96998427
85Wnt signaling pathway_Homo sapiens_hsa043100.95657050
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93108318
87Ether lipid metabolism_Homo sapiens_hsa005650.92630284
88Glutathione metabolism_Homo sapiens_hsa004800.91447561
89Estrogen signaling pathway_Homo sapiens_hsa049150.91314217
90Melanoma_Homo sapiens_hsa052180.91187511
91Hippo signaling pathway_Homo sapiens_hsa043900.90216783
92Focal adhesion_Homo sapiens_hsa045100.89722584
93Cardiac muscle contraction_Homo sapiens_hsa042600.88957303
94Pancreatic secretion_Homo sapiens_hsa049720.88514894
95Selenocompound metabolism_Homo sapiens_hsa004500.87246224
96Fatty acid degradation_Homo sapiens_hsa000710.85927212
97Fanconi anemia pathway_Homo sapiens_hsa034600.84899134
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80447290
99Glioma_Homo sapiens_hsa052140.80129308
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79478070
101Adherens junction_Homo sapiens_hsa045200.78150061
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76885225
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76055244
104Protein digestion and absorption_Homo sapiens_hsa049740.74721674
105Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70966898
106Rap1 signaling pathway_Homo sapiens_hsa040150.69761053
107Regulation of autophagy_Homo sapiens_hsa041400.69557914
108Bile secretion_Homo sapiens_hsa049760.66894365
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66664279
110Proteoglycans in cancer_Homo sapiens_hsa052050.66073474
111Parkinsons disease_Homo sapiens_hsa050120.66072617
112ErbB signaling pathway_Homo sapiens_hsa040120.66041547
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.65846354
114Mineral absorption_Homo sapiens_hsa049780.65690647
115Tight junction_Homo sapiens_hsa045300.64328802
116TGF-beta signaling pathway_Homo sapiens_hsa043500.64223784
117Arachidonic acid metabolism_Homo sapiens_hsa005900.63482957
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.62352567
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61205572
120Ras signaling pathway_Homo sapiens_hsa040140.60711387
121Alzheimers disease_Homo sapiens_hsa050100.59847800
122MAPK signaling pathway_Homo sapiens_hsa040100.59441821
123Lysine degradation_Homo sapiens_hsa003100.58036799
124Fatty acid metabolism_Homo sapiens_hsa012120.57891018
125Inositol phosphate metabolism_Homo sapiens_hsa005620.57230196
126Insulin signaling pathway_Homo sapiens_hsa049100.53910738
127Purine metabolism_Homo sapiens_hsa002300.53260515
128Homologous recombination_Homo sapiens_hsa034400.51595120
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51173533
130Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50653081
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.49367403
132Metabolic pathways_Homo sapiens_hsa011000.49291603
133Sphingolipid metabolism_Homo sapiens_hsa006000.48432103
134Endometrial cancer_Homo sapiens_hsa052130.48222327
135Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48077320
136Choline metabolism in cancer_Homo sapiens_hsa052310.46861732
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.46037894
138Butanoate metabolism_Homo sapiens_hsa006500.44076773
139Insulin resistance_Homo sapiens_hsa049310.43066654
140Prostate cancer_Homo sapiens_hsa052150.41681386
141PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41259107
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.36965468
143MicroRNAs in cancer_Homo sapiens_hsa052060.36499565
144Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35182086

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