CC2D1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcriptional repressor that binds to a conserved 14-bp 5'-repressor element and regulates expression of the 5-hydroxytryptamine (serotonin) receptor 1A gene in neuronal cells. The DNA binding and transcriptional repressor activities of the protein are inhibited by calcium. A mutation in this gene results in nonsyndromic mental retardation-3. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sodium ion export (GO:0071436)4.37820495
2cytoskeletal anchoring at plasma membrane (GO:0007016)4.28794904
3synaptic vesicle maturation (GO:0016188)4.00669322
4cell-cell junction maintenance (GO:0045217)3.92217714
5layer formation in cerebral cortex (GO:0021819)3.80558936
6negative regulation of cell size (GO:0045792)3.77400464
7activation of Rac GTPase activity (GO:0032863)3.76416277
8desmosome organization (GO:0002934)3.75522314
9regulation of synapse maturation (GO:0090128)3.71160635
10negative regulation of erythrocyte differentiation (GO:0045647)3.67006369
11activation of protein kinase A activity (GO:0034199)3.66884308
12semaphorin-plexin signaling pathway (GO:0071526)3.66378021
13locomotory exploration behavior (GO:0035641)3.64602951
14proline biosynthetic process (GO:0006561)3.60124253
15regulation of NFAT protein import into nucleus (GO:0051532)3.46986635
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.44235580
17regulation of hydrogen peroxide metabolic process (GO:0010310)3.40340629
18synaptic vesicle docking involved in exocytosis (GO:0016081)3.40025066
19peptidyl-tyrosine autophosphorylation (GO:0038083)3.39994184
20positive regulation of histone deacetylation (GO:0031065)3.33227011
21regulation of clathrin-mediated endocytosis (GO:2000369)3.32392998
22negative regulation of fatty acid transport (GO:2000192)3.30725774
23peptidyl-lysine dimethylation (GO:0018027)3.30574370
24regulation of short-term neuronal synaptic plasticity (GO:0048172)3.28349239
25regulation of ARF protein signal transduction (GO:0032012)3.28081833
26stress fiber assembly (GO:0043149)3.21474105
27plasma membrane repair (GO:0001778)3.17075302
28apoptotic process involved in morphogenesis (GO:0060561)3.16728052
29regulation of ARF GTPase activity (GO:0032312)3.16071363
30cell junction maintenance (GO:0034331)3.13607794
31proline transport (GO:0015824)3.11251333
32signal complex assembly (GO:0007172)3.10562517
33regulation of early endosome to late endosome transport (GO:2000641)3.08826517
34regulation of mammary gland epithelial cell proliferation (GO:0033599)3.08264979
35positive regulation of CREB transcription factor activity (GO:0032793)3.07629027
36positive regulation of fatty acid beta-oxidation (GO:0032000)3.05367693
37pre-miRNA processing (GO:0031054)3.05254578
38negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.04784885
39negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.04580278
40negative regulation of cell killing (GO:0031342)3.04580278
41cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.04205516
42negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.02001568
43dopamine receptor signaling pathway (GO:0007212)3.01498198
44regulation of tight junction assembly (GO:2000810)2.99532230
45proline metabolic process (GO:0006560)2.96789733
46retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.94664971
47establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.93739258
48mitochondrion transport along microtubule (GO:0047497)2.93739258
49adherens junction assembly (GO:0034333)2.93071302
50regulation of apoptotic process involved in morphogenesis (GO:1902337)2.92919558
51regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.92409515
52positive regulation of synapse maturation (GO:0090129)2.91657777
53activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.87733218
54cellular potassium ion homeostasis (GO:0030007)2.87725407
55cell communication by electrical coupling (GO:0010644)2.82375637
56endothelial cell chemotaxis (GO:0035767)2.79587532
57negative regulation of viral release from host cell (GO:1902187)2.79537555
58apoptotic cell clearance (GO:0043277)2.78622501
59clathrin coat assembly (GO:0048268)2.78496894
60cell-substrate junction assembly (GO:0007044)2.78357868
61establishment of mitochondrion localization (GO:0051654)2.78087544
62receptor catabolic process (GO:0032801)2.78019300
63glutamate secretion (GO:0014047)2.77687502
64protein localization to endosome (GO:0036010)2.76938384
65regulation of histone deacetylation (GO:0031063)2.76899729
66cerebellar Purkinje cell layer development (GO:0021680)2.76835802
67heterochromatin organization (GO:0070828)2.75775982
68intracellular estrogen receptor signaling pathway (GO:0030520)2.72747122
69positive regulation of nuclease activity (GO:0032075)2.72719498
70positive regulation of Cdc42 GTPase activity (GO:0043089)2.72600316
71atrioventricular valve morphogenesis (GO:0003181)2.72426711
72negative regulation of myotube differentiation (GO:0010832)2.71449551
73regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.71264224
74regulation of cholesterol homeostasis (GO:2000188)2.69502218
75NLS-bearing protein import into nucleus (GO:0006607)2.68698598
76antigen processing and presentation via MHC class Ib (GO:0002475)2.68698592
77regulation of hippo signaling (GO:0035330)2.67932475
78positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.67775656
79maternal placenta development (GO:0001893)2.66306137
80Golgi transport vesicle coating (GO:0048200)2.65599662
81COPI coating of Golgi vesicle (GO:0048205)2.65599662
82positive regulation of fibroblast migration (GO:0010763)2.65253315
83regulation of cholesterol metabolic process (GO:0090181)2.64678817
84barbed-end actin filament capping (GO:0051016)2.64581449
85positive regulation of protein dephosphorylation (GO:0035307)2.64323060
86planar cell polarity pathway involved in neural tube closure (GO:0090179)2.63305997
87epithelial cell-cell adhesion (GO:0090136)2.62055628
88actin filament bundle organization (GO:0061572)2.58273433
89actin filament bundle assembly (GO:0051017)2.58273433
90response to acidic pH (GO:0010447)2.57990820
91cell-substrate adherens junction assembly (GO:0007045)2.57679332
92focal adhesion assembly (GO:0048041)2.57679332
93regulation of cholesterol biosynthetic process (GO:0045540)2.57456731
94regulation of translational termination (GO:0006449)2.56661530
95regulation of viral release from host cell (GO:1902186)2.56507077
96glutathione biosynthetic process (GO:0006750)2.56420570
97GDP-mannose metabolic process (GO:0019673)2.55060258
98activation of JUN kinase activity (GO:0007257)2.54527844
99regulation of synapse structural plasticity (GO:0051823)2.54232302
100glucose 6-phosphate metabolic process (GO:0051156)2.53270343
101hemidesmosome assembly (GO:0031581)2.53074524
102maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.52116658
103positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.50526146
104alanine transport (GO:0032328)2.49192286
105regulation of respiratory burst (GO:0060263)2.47747658
106cerebellar granule cell differentiation (GO:0021707)2.47136263
107cellular response to pH (GO:0071467)2.47067323
108macroautophagy (GO:0016236)2.46975187
109protein kinase C signaling (GO:0070528)2.46200782
110regulation of defense response to virus by virus (GO:0050690)2.45839782
111mannose metabolic process (GO:0006013)2.44928707
112regulation of glucose import in response to insulin stimulus (GO:2001273)2.44751108
113negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.43630166
114activation of MAPKKK activity (GO:0000185)2.43314701
115regulation of translational fidelity (GO:0006450)2.43279610
116G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.43094406
117regulation of nuclease activity (GO:0032069)2.42986106
118regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.42828091
119positive regulation of triglyceride biosynthetic process (GO:0010867)2.42786736
120protein targeting to plasma membrane (GO:0072661)2.42610998
121neuromuscular process controlling balance (GO:0050885)2.42249594
122thymic T cell selection (GO:0045061)2.41566377
123regulation of water loss via skin (GO:0033561)2.41431619
124glucocorticoid receptor signaling pathway (GO:0042921)2.39420130
125UV protection (GO:0009650)2.39257566
126insulin-like growth factor receptor signaling pathway (GO:0048009)2.39076708
127histone H4 deacetylation (GO:0070933)2.37970877
128myelin maintenance (GO:0043217)2.37889439
129positive regulation of axon extension (GO:0045773)2.37812316
130creatine metabolic process (GO:0006600)2.37103924
131NADH metabolic process (GO:0006734)2.36508715
132glial cell proliferation (GO:0014009)2.36425432
133establishment of nucleus localization (GO:0040023)2.35636677
134positive thymic T cell selection (GO:0045059)2.35588566
135vesicle transport along microtubule (GO:0047496)2.35112503
136cortical actin cytoskeleton organization (GO:0030866)2.34090163
137dendritic spine organization (GO:0097061)2.33673956
138antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.33538515
139antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.33538515
140vocalization behavior (GO:0071625)2.33409947
141mitotic G1 DNA damage checkpoint (GO:0031571)2.33218188
142exploration behavior (GO:0035640)2.32663450
143synaptic vesicle exocytosis (GO:0016079)2.32489053
144regulation of synaptic vesicle exocytosis (GO:2000300)2.31967030
145polarized epithelial cell differentiation (GO:0030859)2.31610940
146positive regulation of fatty acid oxidation (GO:0046321)2.31190637
147synaptic vesicle endocytosis (GO:0048488)2.30326550
148protein retention in ER lumen (GO:0006621)2.30317833
149post-embryonic morphogenesis (GO:0009886)2.30127514
150stress granule assembly (GO:0034063)2.29803665
151multicellular organismal water homeostasis (GO:0050891)2.29672571
152neurotransmitter secretion (GO:0007269)2.29422208
153cellular sodium ion homeostasis (GO:0006883)2.29300492
154cell migration in hindbrain (GO:0021535)2.29200749
155N-glycan processing (GO:0006491)2.28901668
156regulation of fatty acid beta-oxidation (GO:0031998)2.28324367
157skeletal muscle organ development (GO:0060538)2.28112185
158diaphragm development (GO:0060539)2.27660599
159negative regulation of microtubule polymerization (GO:0031115)2.27459811
160adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.26637483
161cell communication involved in cardiac conduction (GO:0086065)2.26265967
162regulation of gamma-delta T cell differentiation (GO:0045586)2.25559820
163positive regulation of protein deacetylation (GO:0090312)2.25423910
164snRNA metabolic process (GO:0016073)2.24548876
165mammary gland epithelial cell differentiation (GO:0060644)2.24168759
166renal filtration (GO:0097205)2.23127328
1672-oxoglutarate metabolic process (GO:0006103)2.20065521
168positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.19406352

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.13871776
2EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.99908089
3MYC_22102868_ChIP-Seq_BL_Human2.85497793
4STAT6_21828071_ChIP-Seq_BEAS2B_Human2.78113921
5KDM2B_26808549_Chip-Seq_SUP-B15_Human2.73070240
6KDM2B_26808549_Chip-Seq_DND41_Human2.65981585
7TP63_17297297_ChIP-ChIP_HaCaT_Human2.63403539
8LXR_22292898_ChIP-Seq_THP-1_Human2.56022707
9TCF7_22412390_ChIP-Seq_EML_Mouse2.41519982
10ZFP281_18757296_ChIP-ChIP_E14_Mouse2.34204051
11KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.32117715
12KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.27400118
13KDM2B_26808549_Chip-Seq_K562_Human2.13289570
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.12167027
15ELK3_25401928_ChIP-Seq_HUVEC_Human2.08751732
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.04658312
17ZNF263_19887448_ChIP-Seq_K562_Human2.02132471
18VDR_21846776_ChIP-Seq_THP-1_Human2.01635745
19TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.98460664
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.95851286
21RACK7_27058665_Chip-Seq_MCF-7_Human1.95185365
22EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.93403145
23KDM2B_26808549_Chip-Seq_JURKAT_Human1.84196006
24ZFP281_27345836_Chip-Seq_ESCs_Mouse1.81628317
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74577041
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.73911492
27ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.71903899
28TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69683668
29P300_27058665_Chip-Seq_ZR-75-30cells_Human1.67525638
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66677194
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.63858144
32SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.61084172
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.59888823
34DNAJC2_21179169_ChIP-ChIP_NT2_Human1.59320706
35SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.58818293
36DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.56451293
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56441810
38CREB1_26743006_Chip-Seq_LNCaP_Human1.55779839
39DROSHA_22980978_ChIP-Seq_HELA_Human1.55503749
40P68_20966046_ChIP-Seq_HELA_Human1.54486382
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52910123
42GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.52817372
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.50572038
44SMC4_20622854_ChIP-Seq_HELA_Human1.50347659
45ATF3_27146783_Chip-Seq_COLON_Human1.50121375
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.49913280
47STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.49209481
48E2F1_20622854_ChIP-Seq_HELA_Human1.46388138
49RUNX1_27514584_Chip-Seq_MCF-7_Human1.45482989
50MAF_26560356_Chip-Seq_TH1_Human1.44077353
51UTX_26944678_Chip-Seq_JUKART_Human1.43442028
52TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.42361421
53CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.39074998
54UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38527670
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37922423
56ELF1_20517297_ChIP-Seq_JURKAT_Human1.37403939
57ESR1_21235772_ChIP-Seq_MCF-7_Human1.33156649
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32797895
59SA1_27219007_Chip-Seq_Bcells_Human1.31187543
60TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29845510
61RARB_24833708_ChIP-Seq_LIVER_Mouse1.26052876
62SPI1_23127762_ChIP-Seq_K562_Human1.25342243
63MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.25207831
64* TP53_22127205_ChIP-Seq_IMR90_Human1.23414990
65SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.22677773
66CTCF_20526341_ChIP-Seq_ESCs_Human1.22313868
67SA1_27219007_Chip-Seq_ERYTHROID_Human1.21362562
68CLOCK_20551151_ChIP-Seq_293T_Human1.20251382
69EZH2_27294783_Chip-Seq_ESCs_Mouse1.20072043
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.19595007
71CTCF_26484167_Chip-Seq_Bcells_Mouse1.19351300
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.18925028
73SUZ12_27294783_Chip-Seq_ESCs_Mouse1.17844213
74TP63_22573176_ChIP-Seq_HFKS_Human1.16969809
75PPARA_22158963_ChIP-Seq_LIVER_Mouse1.16910553
76ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16856573
77BCOR_27268052_Chip-Seq_Bcells_Human1.16293449
78RARA_24833708_ChIP-Seq_LIVER_Mouse1.15692470
79ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.15552022
80TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14435660
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12993033
82NCOR1_26117541_ChIP-Seq_K562_Human1.12975101
83JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11941381
84SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.11552940
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11534931
86JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.11301830
87ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.11018641
88ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10541358
89ETS1_21867929_ChIP-Seq_TH2_Mouse1.10349949
90CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10204134
91VDR_24763502_ChIP-Seq_THP-1_Human1.08864358
92ERG_21242973_ChIP-ChIP_JURKAT_Human1.08744962
93ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08593375
94GATA1_19941827_ChIP-Seq_MEL_Mouse1.08551486
95HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08505901
96SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07721769
97BCL6_27268052_Chip-Seq_Bcells_Human1.07501263
98FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06584824
99SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06563169
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.06353747
101TET1_21451524_ChIP-Seq_MESCs_Mouse1.05293021
102NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04511263
103P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04037131
104* OCT4_19829295_ChIP-Seq_ESCs_Human1.03662044
105RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02709457
106* PHF8_20622854_ChIP-Seq_HELA_Human1.02187935
107TET1_21490601_ChIP-Seq_MESCs_Mouse1.00889931
108* FOXP1_21924763_ChIP-Seq_HESCs_Human1.00139371
109CTCF_18555785_ChIP-Seq_MESCs_Mouse0.99410799
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99345702
111FOXO3_23340844_ChIP-Seq_DLD1_Human0.98990566
112SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98348912
113YY1_22570637_ChIP-Seq_MALME-3M_Human0.98296629
114CTCF_27219007_Chip-Seq_Bcells_Human0.98220689
115GATA1_19941826_ChIP-Seq_K562_Human0.98095665
116MAF_26560356_Chip-Seq_TH2_Human0.97850272
117TP53_20018659_ChIP-ChIP_R1E_Mouse0.97391162
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97169988
119RXR_22158963_ChIP-Seq_LIVER_Mouse0.96648085
120CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96608385
121SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95746777
122TP53_23651856_ChIP-Seq_MEFs_Mouse0.95646066
123EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95376665
124CTCF_21964334_ChIP-Seq_BJAB-B_Human0.95353230
125TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.94140390
126BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93675760
127KLF5_25053715_ChIP-Seq_YYC3_Human0.91874574
128TBX20_22328084_ChIP-Seq_HEART_Mouse0.90561484
129TBX20_22080862_ChIP-Seq_HEART_Mouse0.90561484
130* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89890719

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.55290804
2MP0004859_abnormal_synaptic_plasticity3.88735240
3MP0000678_abnormal_parathyroid_gland3.81403170
4MP0002249_abnormal_larynx_morphology3.51065729
5MP0010234_abnormal_vibrissa_follicle3.42472516
6MP0003283_abnormal_digestive_organ2.97299642
7MP0010352_gastrointestinal_tract_polyps2.94026226
8MP0005360_urolithiasis2.92109852
9MP0003300_gastrointestinal_ulcer2.78871239
10MP0008961_abnormal_basal_metabolism2.64629186
11MP0005076_abnormal_cell_differentiation2.63914702
12MP0004858_abnormal_nervous_system2.51025651
13MP0005409_darkened_coat_color2.35478268
14MP0003303_peritoneal_inflammation2.20504140
15MP0005451_abnormal_body_composition2.13485544
16MP0005623_abnormal_meninges_morphology2.13146222
17MP0003566_abnormal_cell_adhesion2.09255332
18MP0001849_ear_inflammation2.03853929
19MP0003045_fibrosis1.90475893
20MP0000569_abnormal_digit_pigmentation1.89973160
21MP0002877_abnormal_melanocyte_morpholog1.84210756
22MP0003183_abnormal_peptide_metabolism1.82508047
23MP0009780_abnormal_chondrocyte_physiolo1.81926741
24MP0005670_abnormal_white_adipose1.80698017
25MP0000566_synostosis1.78222644
26MP0002822_catalepsy1.78011055
27MP0000579_abnormal_nail_morphology1.77181043
28MP0002909_abnormal_adrenal_gland1.77001240
29MP0003329_amyloid_beta_deposits1.76062712
30MP0003172_abnormal_lysosome_physiology1.73017769
31MP0009278_abnormal_bone_marrow1.71356887
32MP0001348_abnormal_lacrimal_gland1.67619939
33MP0000467_abnormal_esophagus_morphology1.66047484
34MP0004233_abnormal_muscle_weight1.65829730
35MP0000751_myopathy1.62144124
36MP0004510_myositis1.60100898
37MP0001502_abnormal_circadian_rhythm1.59417985
38MP0003635_abnormal_synaptic_transmissio1.59099588
39MP0002098_abnormal_vibrissa_morphology1.58999936
40MP0003091_abnormal_cell_migration1.56591541
41MP0009379_abnormal_foot_pigmentation1.56087981
42MP0004043_abnormal_pH_regulation1.54926726
43MP0000681_abnormal_thyroid_gland1.48178547
44MP0002653_abnormal_ependyma_morphology1.44872275
45MP0001664_abnormal_digestion1.43602683
46MP0004947_skin_inflammation1.42810458
47MP0008438_abnormal_cutaneous_collagen1.40596929
48MP0005023_abnormal_wound_healing1.40584913
49MP0000013_abnormal_adipose_tissue1.40425751
50MP0004381_abnormal_hair_follicle1.36631513
51MP0002064_seizures1.35234453
52MP0002089_abnormal_postnatal_growth/wei1.29174470
53MP0000733_abnormal_muscle_development1.28170971
54MP0005275_abnormal_skin_tensile1.24878035
55MP0000003_abnormal_adipose_tissue1.24232010
56MP0001765_abnormal_ion_homeostasis1.22736650
57MP0002269_muscular_atrophy1.18617265
58MP0004264_abnormal_extraembryonic_tissu1.18431359
59MP0000604_amyloidosis1.18195792
60MP0004811_abnormal_neuron_physiology1.16878392
61MP0004185_abnormal_adipocyte_glucose1.15726084
62MP0005423_abnormal_somatic_nervous1.15172700
63MP0010307_abnormal_tumor_latency1.14007159
64MP0003075_altered_response_to1.12322528
65MP0000747_muscle_weakness1.11472100
66MP0002796_impaired_skin_barrier1.10877076
67MP0003866_abnormal_defecation1.08380102
68MP0004087_abnormal_muscle_fiber1.07951332
69MP0000537_abnormal_urethra_morphology1.06981278
70MP0001188_hyperpigmentation1.06780745
71MP0003879_abnormal_hair_cell1.06698449
72MP0001873_stomach_inflammation1.06559084
73MP0008770_decreased_survivor_rate1.04643508
74MP0004782_abnormal_surfactant_physiolog1.04217638
75MP0005365_abnormal_bile_salt1.03971748
76MP0004130_abnormal_muscle_cell0.99001150
77MP0008260_abnormal_autophagy0.98999223
78MP0004270_analgesia0.98883442
79MP0002063_abnormal_learning/memory/cond0.98746927
80MP0003279_aneurysm0.97860188
81MP0000534_abnormal_ureter_morphology0.96764288
82MP0003123_paternal_imprinting0.94999293
83MP0005375_adipose_tissue_phenotype0.94745298
84MP0002734_abnormal_mechanical_nocicepti0.93780787
85MP0001970_abnormal_pain_threshold0.93357428
86MP0002572_abnormal_emotion/affect_behav0.92371478
87MP0001958_emphysema0.91308296
88MP0002234_abnormal_pharynx_morphology0.91109359
89MP0001346_abnormal_lacrimal_gland0.90812146
90MP0005058_abnormal_lysosome_morphology0.89917635
91MP0002254_reproductive_system_inflammat0.89449554
92MP0008569_lethality_at_weaning0.88203860
93MP0009333_abnormal_splenocyte_physiolog0.87610288
94MP0003453_abnormal_keratinocyte_physiol0.87499881
95MP0003787_abnormal_imprinting0.86386936
96MP0002896_abnormal_bone_mineralization0.84534792
97MP0000685_abnormal_immune_system0.83115043
98MP0002970_abnormal_white_adipose0.82701297
99MP0009931_abnormal_skin_appearance0.82623334
100MP0009643_abnormal_urine_homeostasis0.82154803
101MP0000470_abnormal_stomach_morphology0.81200804
102MP0000462_abnormal_digestive_system0.80390839
103MP0003634_abnormal_glial_cell0.80272408
104MP0001968_abnormal_touch/_nociception0.79971983
105MP0000759_abnormal_skeletal_muscle0.79720929
106MP0002876_abnormal_thyroid_physiology0.79454533
107MP0000538_abnormal_urinary_bladder0.79141480
108MP0003115_abnormal_respiratory_system0.78144810
109MP0004808_abnormal_hematopoietic_stem0.77517830
110MP0005397_hematopoietic_system_phenotyp0.77005744
111MP0001545_abnormal_hematopoietic_system0.77005744
112MP0002166_altered_tumor_susceptibility0.76457806
113MP0004019_abnormal_vitamin_homeostasis0.75756733
114MP0009840_abnormal_foam_cell0.75537522
115MP0010771_integument_phenotype0.75055223
116MP0001270_distended_abdomen0.74552099
117MP0009745_abnormal_behavioral_response0.74454793
118MP0004197_abnormal_fetal_growth/weight/0.73275960
119MP0005167_abnormal_blood-brain_barrier0.72949690
120MP0005083_abnormal_biliary_tract0.70215627
121MP0001730_embryonic_growth_arrest0.69139850
122MP0010630_abnormal_cardiac_muscle0.68978109
123MP0005621_abnormal_cell_physiology0.68969484
124MP0005166_decreased_susceptibility_to0.67874290
125MP0002086_abnormal_extraembryonic_tissu0.67295442
126MP0002932_abnormal_joint_morphology0.66925393
127MP0000858_altered_metastatic_potential0.66135295
128MP0005310_abnormal_salivary_gland0.66014885
129MP0002084_abnormal_developmental_patter0.65749237
130MP0005501_abnormal_skin_physiology0.65741700
131MP0005666_abnormal_adipose_tissue0.65729140
132MP0005381_digestive/alimentary_phenotyp0.65194414
133MP0002118_abnormal_lipid_homeostasis0.64485938
134MP0010155_abnormal_intestine_physiology0.64230542
135MP0003191_abnormal_cellular_cholesterol0.64168862
136MP0009384_cardiac_valve_regurgitation0.64084661
137MP0010329_abnormal_lipoprotein_level0.63809376
138MP0002060_abnormal_skin_morphology0.63662973
139MP0002272_abnormal_nervous_system0.63502170
140MP0002925_abnormal_cardiovascular_devel0.62209314
141MP0008874_decreased_physiological_sensi0.62038367
142MP0003448_altered_tumor_morphology0.61240665
143MP0001663_abnormal_digestive_system0.61008260
144MP0000477_abnormal_intestine_morphology0.59637551
145MP0003763_abnormal_thymus_physiology0.59510503
146MP0002168_other_aberrant_phenotype0.59504248
147MP0000703_abnormal_thymus_morphology0.58091230
148MP0000358_abnormal_cell_content/0.55699151
149MP0002733_abnormal_thermal_nociception0.55694868
150MP0002396_abnormal_hematopoietic_system0.54978877

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.42880476
2Stridor (HP:0010307)4.27318035
3Cerebral aneurysm (HP:0004944)3.81192953
4Distal upper limb amyotrophy (HP:0007149)3.76428383
5Upper limb amyotrophy (HP:0009129)3.76428383
6Hand muscle atrophy (HP:0009130)3.69013342
7Abnormality of the lower motor neuron (HP:0002366)3.63901974
8Hyperacusis (HP:0010780)3.62804909
9J-shaped sella turcica (HP:0002680)3.52726506
10Hyperthyroidism (HP:0000836)3.28768786
11Protrusio acetabuli (HP:0003179)3.09184096
12Abnormality of the aortic arch (HP:0012303)3.05636921
13Shallow orbits (HP:0000586)2.99593071
14Broad face (HP:0000283)2.97420672
15Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.94327816
16Myopathic facies (HP:0002058)2.83827106
17Truncus arteriosus (HP:0001660)2.81891956
18Hyperparathyroidism (HP:0000843)2.71958270
19Easy fatigability (HP:0003388)2.65119026
20Hemorrhage of the eye (HP:0011885)2.64001251
21Increased neuronal autofluorescent lipopigment (HP:0002074)2.62388686
22Achilles tendon contracture (HP:0001771)2.61116061
23Difficulty climbing stairs (HP:0003551)2.60589488
24Increased connective tissue (HP:0009025)2.56458076
25Insomnia (HP:0100785)2.54476500
26Visual hallucinations (HP:0002367)2.53141649
27Ankle contracture (HP:0006466)2.51099409
28Genu recurvatum (HP:0002816)2.50308933
29Distal lower limb muscle weakness (HP:0009053)2.43058255
30Atelectasis (HP:0100750)2.40990736
31Increased cerebral lipofuscin (HP:0011813)2.40184478
32Pointed chin (HP:0000307)2.39767443
33Abnormality of the Achilles tendon (HP:0005109)2.37145760
34Pili torti (HP:0003777)2.35592297
35Supranuclear gaze palsy (HP:0000605)2.35280988
36Bowel diverticulosis (HP:0005222)2.32754476
37Astrocytoma (HP:0009592)2.31520202
38Abnormality of the astrocytes (HP:0100707)2.31520202
39Hypercortisolism (HP:0001578)2.30068585
40Dysmetric saccades (HP:0000641)2.28741890
41Elfin facies (HP:0004428)2.28725920
42Aneurysm (HP:0002617)2.28424159
43Macroorchidism (HP:0000053)2.27941495
44Frequent falls (HP:0002359)2.27249407
45Aortic aneurysm (HP:0004942)2.26971007
46Neoplasm of the heart (HP:0100544)2.26346510
47Long toe (HP:0010511)2.26027652
48Mildly elevated creatine phosphokinase (HP:0008180)2.22936200
49Dilatation of the ascending aorta (HP:0005111)2.22410602
50Bronchomalacia (HP:0002780)2.21909496
51Hemiplegia (HP:0002301)2.19948306
52Germ cell neoplasia (HP:0100728)2.19767976
53Broad metatarsal (HP:0001783)2.19659044
54Abdominal distention (HP:0003270)2.19581827
55Abnormality of the thoracic spine (HP:0100711)2.19423758
56Malnutrition (HP:0004395)2.19129947
57Renovascular hypertension (HP:0100817)2.18781998
58Nasal polyposis (HP:0100582)2.18208679
59Segmental peripheral demyelination/remyelination (HP:0003481)2.17720611
60Bladder diverticulum (HP:0000015)2.17295919
61Abnormality of glutamine family amino acid metabolism (HP:0010902)2.17046631
62Rectal prolapse (HP:0002035)2.16684045
63Mitral valve prolapse (HP:0001634)2.16182498
64Myokymia (HP:0002411)2.16156519
65Abnormal hair laboratory examination (HP:0003328)2.15644803
66Increased variability in muscle fiber diameter (HP:0003557)2.10103220
67Amyotrophic lateral sclerosis (HP:0007354)2.09553105
68Bowel incontinence (HP:0002607)2.08500598
69Premature skin wrinkling (HP:0100678)2.07139436
70Striae distensae (HP:0001065)2.06111243
71Flat acetabular roof (HP:0003180)2.06078259
72Fragile skin (HP:0001030)2.05851448
73Atrophic scars (HP:0001075)2.05046648
74Lower limb amyotrophy (HP:0007210)2.04507723
75Turricephaly (HP:0000262)2.01800722
76Long palpebral fissure (HP:0000637)2.01084318
77Diaphragmatic weakness (HP:0009113)1.99954290
78Enlarged penis (HP:0000040)1.99868858
79Seborrheic dermatitis (HP:0001051)1.99787368
80Difficulty running (HP:0009046)1.99661564
81Reticulocytosis (HP:0001923)1.98649525
82Subacute progressive viral hepatitis (HP:0006572)1.97927687
83Lymphangioma (HP:0100764)1.97872593
84Ependymoma (HP:0002888)1.97865577
85Bundle branch block (HP:0011710)1.97345980
86Renal duplication (HP:0000075)1.95443051
87Premature rupture of membranes (HP:0001788)1.94156103
88Abnormality of oral frenula (HP:0000190)1.93878745
89Broad distal phalanx of finger (HP:0009836)1.91577773
90Apathy (HP:0000741)1.91340427
91Ankle clonus (HP:0011448)1.91274052
92Onion bulb formation (HP:0003383)1.91239693
93Abnormal large intestine physiology (HP:0012700)1.91037221
94Abnormality of the nasal mucosa (HP:0000433)1.90468657
95Rapidly progressive (HP:0003678)1.90272996
96Patellar dislocation (HP:0002999)1.90174205
97Mesangial abnormality (HP:0001966)1.89707548
98Abnormality of skeletal muscle fiber size (HP:0012084)1.87605066
99Disproportionate tall stature (HP:0001519)1.87428749
100Genetic anticipation (HP:0003743)1.86829492
101Bulbar palsy (HP:0001283)1.86735561
102Neuronal loss in central nervous system (HP:0002529)1.86450674
103Milia (HP:0001056)1.85253307
104Axonal loss (HP:0003447)1.85176705
105Increased density of long bones (HP:0006392)1.84476586
106Heterotopia (HP:0002282)1.83866165
107Akinesia (HP:0002304)1.82910182
108Sleep apnea (HP:0010535)1.82708025
109Type 1 muscle fiber predominance (HP:0003803)1.81501038
110Peripheral hypomyelination (HP:0007182)1.81329299
111Overriding aorta (HP:0002623)1.80587730
112Radial bowing (HP:0002986)1.80152234
113Dysostosis multiplex (HP:0000943)1.80121321
114Diminished motivation (HP:0000745)1.78718063
115Microretrognathia (HP:0000308)1.77248939
116Ankyloglossia (HP:0010296)1.75950754
117Papilledema (HP:0001085)1.74646223
118Hyporeflexia of lower limbs (HP:0002600)1.73446835
119Testicular atrophy (HP:0000029)1.73232014
120Abnormal gallbladder physiology (HP:0012438)1.72929803
121Cholecystitis (HP:0001082)1.72929803
122Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.72916869
123Growth hormone excess (HP:0000845)1.72824437
124Thin bony cortex (HP:0002753)1.71852923
125Peritonitis (HP:0002586)1.70834815
126Spinal canal stenosis (HP:0003416)1.70758943
127Fibroma (HP:0010614)1.70464883
128Aortic dissection (HP:0002647)1.69129363
129Resting tremor (HP:0002322)1.69013444
130Abnormality of the distal phalanges of the toes (HP:0010182)1.68642416
131Right ventricular cardiomyopathy (HP:0011663)1.68517976
132Hallux valgus (HP:0001822)1.68450007
133Distal lower limb amyotrophy (HP:0008944)1.68410219
134Impaired smooth pursuit (HP:0007772)1.68360020
135Deviation of the hallux (HP:0010051)1.68041203
136Precocious puberty (HP:0000826)1.67665828
137Hypoventilation (HP:0002791)1.67356517
138Truncal ataxia (HP:0002078)1.67083477
139Oligodontia (HP:0000677)1.66497609
140Ulnar bowing (HP:0003031)1.66199488
141Neurofibrillary tangles (HP:0002185)1.65276240
142Urinary bladder sphincter dysfunction (HP:0002839)1.65009911
143Annular pancreas (HP:0001734)1.64726906
144EMG: neuropathic changes (HP:0003445)1.63981121
145Postural instability (HP:0002172)1.63926532
146Hydroxyprolinuria (HP:0003080)1.63453646
147Abnormality of proline metabolism (HP:0010907)1.63453646
148Polygenic inheritance (HP:0010982)1.63385920
149Abnormality of the fingertips (HP:0001211)1.63009703
150Hyperphosphatemia (HP:0002905)1.62761248
151Urinary urgency (HP:0000012)1.62341666
152Hypoparathyroidism (HP:0000829)1.62339081
153Limb-girdle muscle atrophy (HP:0003797)1.62297803
154Asymmetric septal hypertrophy (HP:0001670)1.62278068
155Cerebral inclusion bodies (HP:0100314)1.61917485
156Abnormality of polysaccharide metabolism (HP:0011012)1.61870017
157Abnormality of glycosaminoglycan metabolism (HP:0004371)1.61870017
158Abnormality of mucopolysaccharide metabolism (HP:0011020)1.61870017
159Joint stiffness (HP:0001387)1.59561382
160Flat cornea (HP:0007720)1.58980103
161Exercise-induced myalgia (HP:0003738)1.58008050
162Bowing of the arm (HP:0006488)1.57928994
163Bowed forearm bones (HP:0003956)1.57928994
164Cervical subluxation (HP:0003308)1.57822477
165Emphysema (HP:0002097)1.57809182
166Fibrous tissue neoplasm (HP:0012316)1.56185580
167Mutism (HP:0002300)1.54601021
168Hamartoma of the eye (HP:0010568)1.53735509
169Fatigue (HP:0012378)1.53213663

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.61179180
2SMG13.71853771
3PKN23.40660073
4EEF2K3.16611977
5MAP3K92.97833004
6ERN12.72319048
7MAP3K102.49253266
8PRKD32.47442027
9RIPK12.40480239
10TAOK12.13273199
11MST1R1.99008953
12IRAK31.88614942
13CDK121.85402759
14TTN1.82472426
15KSR21.81814885
16ICK1.74050608
17SCYL21.73872496
18CAMKK11.73401619
19PRPF4B1.68853888
20PTK61.67912862
21LATS21.58749630
22PAK61.57423728
23PDGFRA1.57102818
24MAP3K111.50579340
25SIK21.50315554
26TYRO31.42430546
27ALK1.42037206
28STK381.40461320
29TESK11.37263798
30DAPK21.35293110
31MAP2K61.33332959
32BMX1.30495042
33MAP2K21.29017948
34NTRK31.27618419
35PRKCH1.25326478
36SIK11.22620408
37NME21.20666988
38MAP3K71.18361221
39DDR21.17520437
40MARK11.16064767
41MARK21.10248680
42RET1.09836699
43PTK21.06334891
44MAP4K11.03599768
45CAMK1G1.01231639
46MTOR1.00302919
47LRRK20.99221837
48ARAF0.97808496
49FGFR40.97562418
50NEK10.96323999
51MAPK110.96256737
52CAMK1D0.94906062
53GRK60.94898371
54PAK40.94230238
55MINK10.93981264
56MAP3K60.93077352
57MAP3K40.90402973
58RIPK40.90261950
59LMTK20.89519939
60PRKG20.88752248
61HIPK20.87648766
62MAPK120.86814682
63DMPK0.85717866
64MAPKAPK30.84251669
65PRKCI0.83887930
66MUSK0.83119387
67PRKD20.83062019
68MAP3K20.82990861
69NTRK10.81393111
70SIK30.80522821
71MAP2K30.77822562
72RPS6KA20.76571296
73NTRK20.76548596
74MAPK150.76469470
75DAPK10.75954692
76PAK20.72481005
77PAK30.71737196
78CDC42BPA0.68799724
79FER0.68602847
80PHKG10.67233784
81PHKG20.67233784
82RPS6KC10.66005361
83RPS6KL10.66005361
84PDK10.65512388
85JAK10.64742569
86IRAK20.63910817
87MAP3K130.62440416
88RPS6KA60.60711086
89PDGFRB0.59561787
90FGFR30.59397309
91PIM20.58676444
92STK110.57937623
93PDK30.57422424
94PDK40.57422424
95DYRK1B0.56816809
96NEK20.55943683
97KSR10.55845958
98BRAF0.55488777
99MAP3K10.54983246
100WNK40.54895661
101STK100.54430199
102CDK50.54088215
103PRKAA10.54043441
104EPHA40.53838250
105MAP3K30.53114332
106CDK150.52481827
107MET0.49858377
108DAPK30.49846187
109NME10.49114676
110CAMK10.48800827
111PDPK10.48461327
112SGK30.48104829
113MAP2K40.47534949
114MAP2K10.46171592
115CDK11A0.45314515
116ILK0.45211883
117CDK180.44877297
118TESK20.44798906
119PRKCZ0.42955592
120TNK20.42836216
121RAF10.42685494
122PTK2B0.42364390
123JAK20.41904450
124RPS6KB20.41578614
125KDR0.41465422
126TYK20.41377736
127CAMK2B0.40621310
128CDK60.39949062
129TAOK20.39922039
130ZAP700.39718156
131CDK140.39485393
132HCK0.39048903
133CAMK2G0.38822352
134EPHA20.38318841
135FGFR10.36855542
136CDK40.36815650
137AKT20.35805419
138PRKAA20.35604808
139EPHB10.34762389
140TBK10.34064519
141BCKDK0.33806796
142MAPK80.33301575

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.51417772
2Sulfur relay system_Homo sapiens_hsa041222.43604220
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20172403
4Other glycan degradation_Homo sapiens_hsa005112.15960955
5Fructose and mannose metabolism_Homo sapiens_hsa000511.94221103
6Synaptic vesicle cycle_Homo sapiens_hsa047211.62008487
7Glycosaminoglycan degradation_Homo sapiens_hsa005311.59450359
8mTOR signaling pathway_Homo sapiens_hsa041501.56245727
9Arginine biosynthesis_Homo sapiens_hsa002201.55913048
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.49361803
11Glioma_Homo sapiens_hsa052141.48928702
12Long-term potentiation_Homo sapiens_hsa047201.43285123
13Type II diabetes mellitus_Homo sapiens_hsa049301.42898960
14Estrogen signaling pathway_Homo sapiens_hsa049151.42634057
15Endometrial cancer_Homo sapiens_hsa052131.41326852
16Carbohydrate digestion and absorption_Homo sapiens_hsa049731.40944313
17VEGF signaling pathway_Homo sapiens_hsa043701.39438618
18Chronic myeloid leukemia_Homo sapiens_hsa052201.37530314
19Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34940791
20Gastric acid secretion_Homo sapiens_hsa049711.34644894
21Neurotrophin signaling pathway_Homo sapiens_hsa047221.34555455
22Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31828116
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30628126
24Thyroid hormone signaling pathway_Homo sapiens_hsa049191.26630347
25Non-small cell lung cancer_Homo sapiens_hsa052231.26510096
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.24691235
27Olfactory transduction_Homo sapiens_hsa047401.24427432
28Galactose metabolism_Homo sapiens_hsa000521.24372293
29GnRH signaling pathway_Homo sapiens_hsa049121.24121110
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.22012071
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.21421493
32Arginine and proline metabolism_Homo sapiens_hsa003301.18832772
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17785679
34Salivary secretion_Homo sapiens_hsa049701.15158827
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.13438573
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.12963940
37Nitrogen metabolism_Homo sapiens_hsa009101.11390582
38Bladder cancer_Homo sapiens_hsa052191.10686924
39Insulin signaling pathway_Homo sapiens_hsa049101.09683151
40Oxytocin signaling pathway_Homo sapiens_hsa049211.09011239
41Insulin secretion_Homo sapiens_hsa049111.07624848
42Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06768610
43Histidine metabolism_Homo sapiens_hsa003401.06296821
44Gap junction_Homo sapiens_hsa045401.05480410
45Longevity regulating pathway - mammal_Homo sapiens_hsa042111.05030603
46Pentose phosphate pathway_Homo sapiens_hsa000301.04787810
47Circadian entrainment_Homo sapiens_hsa047131.04548577
48Dorso-ventral axis formation_Homo sapiens_hsa043201.03746781
49Focal adhesion_Homo sapiens_hsa045101.03617052
50Pancreatic cancer_Homo sapiens_hsa052121.02766994
51Colorectal cancer_Homo sapiens_hsa052101.02413536
52Fat digestion and absorption_Homo sapiens_hsa049751.01836108
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.99767776
54Proteoglycans in cancer_Homo sapiens_hsa052050.99645146
55Glycerophospholipid metabolism_Homo sapiens_hsa005640.98180326
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97194942
57Insulin resistance_Homo sapiens_hsa049310.96887243
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.96815288
59Dopaminergic synapse_Homo sapiens_hsa047280.96344081
60Prion diseases_Homo sapiens_hsa050200.96284738
61Acute myeloid leukemia_Homo sapiens_hsa052210.96019537
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.95767476
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.95554858
64Cholinergic synapse_Homo sapiens_hsa047250.95513575
65Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95191040
66ABC transporters_Homo sapiens_hsa020100.94557694
67B cell receptor signaling pathway_Homo sapiens_hsa046620.93796889
68Biosynthesis of amino acids_Homo sapiens_hsa012300.93737413
69Glucagon signaling pathway_Homo sapiens_hsa049220.93638496
70Prolactin signaling pathway_Homo sapiens_hsa049170.91233923
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91116376
72Endocytosis_Homo sapiens_hsa041440.90923020
73Bile secretion_Homo sapiens_hsa049760.90589140
74ErbB signaling pathway_Homo sapiens_hsa040120.88882612
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87724327
76Dilated cardiomyopathy_Homo sapiens_hsa054140.86278544
77Adherens junction_Homo sapiens_hsa045200.85711617
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.85106695
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83373523
80Amphetamine addiction_Homo sapiens_hsa050310.82895914
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81879832
82Renin secretion_Homo sapiens_hsa049240.81009255
83Amoebiasis_Homo sapiens_hsa051460.79177615
84Renal cell carcinoma_Homo sapiens_hsa052110.78826048
85GABAergic synapse_Homo sapiens_hsa047270.78381648
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77513418
87Platelet activation_Homo sapiens_hsa046110.75987501
88AMPK signaling pathway_Homo sapiens_hsa041520.75378445
89Notch signaling pathway_Homo sapiens_hsa043300.74973555
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74832221
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74826308
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74620522
93Vitamin B6 metabolism_Homo sapiens_hsa007500.73904980
94Toxoplasmosis_Homo sapiens_hsa051450.73278229
95T cell receptor signaling pathway_Homo sapiens_hsa046600.73186662
96Vibrio cholerae infection_Homo sapiens_hsa051100.73170130
97Choline metabolism in cancer_Homo sapiens_hsa052310.72451389
98Thyroid cancer_Homo sapiens_hsa052160.72388935
99Glutamatergic synapse_Homo sapiens_hsa047240.72196063
100Lysosome_Homo sapiens_hsa041420.71351797
101MAPK signaling pathway_Homo sapiens_hsa040100.71212511
102Rap1 signaling pathway_Homo sapiens_hsa040150.71103349
103Melanogenesis_Homo sapiens_hsa049160.70770241
104Hepatitis C_Homo sapiens_hsa051600.70530621
105Small cell lung cancer_Homo sapiens_hsa052220.70369658
106Phenylalanine metabolism_Homo sapiens_hsa003600.69948618
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.69090304
108Fatty acid biosynthesis_Homo sapiens_hsa000610.68942371
109HIF-1 signaling pathway_Homo sapiens_hsa040660.68098098
110Lysine degradation_Homo sapiens_hsa003100.67217688
111Osteoclast differentiation_Homo sapiens_hsa043800.66797262
112Thyroid hormone synthesis_Homo sapiens_hsa049180.66235331
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64890165
114cAMP signaling pathway_Homo sapiens_hsa040240.64513079
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64308509
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63951321
117Cocaine addiction_Homo sapiens_hsa050300.63762539
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63468392
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63296128
120Hippo signaling pathway_Homo sapiens_hsa043900.62954930
121Inositol phosphate metabolism_Homo sapiens_hsa005620.61641860
122Glycerolipid metabolism_Homo sapiens_hsa005610.61206596
123Oocyte meiosis_Homo sapiens_hsa041140.60872301
124Tight junction_Homo sapiens_hsa045300.60371929
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59966123
126Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.59861576
127Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59362146
128Pancreatic secretion_Homo sapiens_hsa049720.58741353
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58043822
130Long-term depression_Homo sapiens_hsa047300.57172731
131Vitamin digestion and absorption_Homo sapiens_hsa049770.56469770
132Axon guidance_Homo sapiens_hsa043600.55296142
133PPAR signaling pathway_Homo sapiens_hsa033200.54149133
134Protein digestion and absorption_Homo sapiens_hsa049740.51411424
135Mineral absorption_Homo sapiens_hsa049780.51175962
136Vascular smooth muscle contraction_Homo sapiens_hsa042700.51170696
137Ovarian steroidogenesis_Homo sapiens_hsa049130.50835097
138Calcium signaling pathway_Homo sapiens_hsa040200.46375788
139Sphingolipid signaling pathway_Homo sapiens_hsa040710.45464531

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