CBX5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family. The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The encoded product is involved in the formation of functional kinetochore through interaction with essential kinetochore proteins. The gene has a pseudogene located on chromosome 3. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.41930959
2DNA unwinding involved in DNA replication (GO:0006268)4.76556490
3protein localization to kinetochore (GO:0034501)4.75214164
4sister chromatid segregation (GO:0000819)4.66874792
5nuclear pore organization (GO:0006999)4.59675270
6nuclear pore complex assembly (GO:0051292)4.53783747
7kinetochore organization (GO:0051383)4.38577154
8mitotic sister chromatid segregation (GO:0000070)4.34744523
9mitotic sister chromatid cohesion (GO:0007064)4.18975067
10pyrimidine nucleobase catabolic process (GO:0006208)4.13555253
11mitotic chromosome condensation (GO:0007076)4.10753988
12DNA topological change (GO:0006265)3.95003450
13protein localization to chromosome, centromeric region (GO:0071459)3.83166074
14presynaptic membrane assembly (GO:0097105)3.80470457
15CENP-A containing nucleosome assembly (GO:0034080)3.74910674
16mitotic metaphase plate congression (GO:0007080)3.73363458
17chromatin remodeling at centromere (GO:0031055)3.67214672
18pre-miRNA processing (GO:0031054)3.62882589
19kinetochore assembly (GO:0051382)3.57864312
20mitotic nuclear envelope disassembly (GO:0007077)3.53969253
21DNA replication-dependent nucleosome assembly (GO:0006335)3.51545414
22DNA replication-dependent nucleosome organization (GO:0034723)3.51545414
23DNA replication-independent nucleosome organization (GO:0034724)3.49582813
24DNA replication-independent nucleosome assembly (GO:0006336)3.49582813
25mitotic recombination (GO:0006312)3.47525665
26DNA strand elongation involved in DNA replication (GO:0006271)3.46310467
27metaphase plate congression (GO:0051310)3.44106290
28paraxial mesoderm development (GO:0048339)3.43893768
29pore complex assembly (GO:0046931)3.40708194
30regulation of sister chromatid cohesion (GO:0007063)3.40011165
31spindle checkpoint (GO:0031577)3.38877921
32IMP biosynthetic process (GO:0006188)3.36892752
33DNA replication initiation (GO:0006270)3.36871418
34DNA geometric change (GO:0032392)3.36206082
35regulation of DNA endoreduplication (GO:0032875)3.36138979
36DNA duplex unwinding (GO:0032508)3.34982162
37membrane disassembly (GO:0030397)3.34708651
38nuclear envelope disassembly (GO:0051081)3.34708651
39regulation of centriole replication (GO:0046599)3.33013909
40attachment of spindle microtubules to kinetochore (GO:0008608)3.32130483
41DNA strand elongation (GO:0022616)3.32048690
42meiotic chromosome segregation (GO:0045132)3.30726822
43positive regulation of mitotic sister chromatid separation (GO:1901970)3.29832280
44positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.29832280
45positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.29832280
46negative regulation of DNA repair (GO:0045738)3.29225449
47histone exchange (GO:0043486)3.27582967
48nucleobase catabolic process (GO:0046113)3.27492810
49glucocorticoid receptor signaling pathway (GO:0042921)3.26613817
50presynaptic membrane organization (GO:0097090)3.26208350
51telomere maintenance via semi-conservative replication (GO:0032201)3.24665946
52regulation of centrosome cycle (GO:0046605)3.21915685
53spindle assembly checkpoint (GO:0071173)3.21324941
54establishment of chromosome localization (GO:0051303)3.21218107
55negative regulation of chromosome segregation (GO:0051985)3.17834104
56double-strand break repair via nonhomologous end joining (GO:0006303)3.16244340
57non-recombinational repair (GO:0000726)3.16244340
58regulation of mitotic metaphase/anaphase transition (GO:0030071)3.16211403
59regulation of spindle organization (GO:0090224)3.15796694
60mitotic spindle checkpoint (GO:0071174)3.15750485
61regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.15009787
62regulation of centrosome duplication (GO:0010824)3.14975072
63DNA strand renaturation (GO:0000733)3.14850705
64chromosome segregation (GO:0007059)3.14532641
65negative regulation of DNA recombination (GO:0045910)3.13912953
66regulation of mitotic sister chromatid separation (GO:0010965)3.13239033
67regulation of mitotic sister chromatid segregation (GO:0033047)3.13239033
68regulation of sister chromatid segregation (GO:0033045)3.13239033
69regulation of chromosome segregation (GO:0051983)3.12808525
70negative regulation of mitotic sister chromatid separation (GO:2000816)3.11827120
71negative regulation of mitotic sister chromatid segregation (GO:0033048)3.11827120
72negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.11827120
73negative regulation of sister chromatid segregation (GO:0033046)3.11827120
74negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.11544976
75mitotic spindle assembly checkpoint (GO:0007094)3.10151255
76establishment of integrated proviral latency (GO:0075713)3.09661607
77nucleobase biosynthetic process (GO:0046112)3.08545546
78DNA double-strand break processing (GO:0000729)3.08459901
79telomere maintenance via recombination (GO:0000722)3.07651586
80negative regulation of DNA-dependent DNA replication (GO:2000104)3.07627088
81regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.07355675
82positive regulation of chromosome segregation (GO:0051984)3.04914000
83dosage compensation (GO:0007549)3.03751118
84protein localization to chromosome (GO:0034502)3.03663711
85ATP-dependent chromatin remodeling (GO:0043044)3.03532217
86nucleotide-excision repair, DNA gap filling (GO:0006297)3.01765236
87replication fork processing (GO:0031297)3.01314802
88negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.00495715
89somatic hypermutation of immunoglobulin genes (GO:0016446)2.96458920
90somatic diversification of immune receptors via somatic mutation (GO:0002566)2.96458920
91postreplication repair (GO:0006301)2.93726607
92negative regulation of translation, ncRNA-mediated (GO:0040033)2.93722360
93regulation of translation, ncRNA-mediated (GO:0045974)2.93722360
94negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.93722360
95DNA conformation change (GO:0071103)2.93530643
96chromatin assembly or disassembly (GO:0006333)2.92558965
97regulation of double-strand break repair (GO:2000779)2.89495220
98regulation of histone H3-K9 methylation (GO:0051570)2.86556261
99purine nucleobase biosynthetic process (GO:0009113)2.84730766
100chromosome condensation (GO:0030261)2.84424203
101resolution of meiotic recombination intermediates (GO:0000712)2.84230351
102regulation of RNA export from nucleus (GO:0046831)2.83900010
103olfactory bulb development (GO:0021772)2.82385697
104limb bud formation (GO:0060174)2.81170904
105microtubule depolymerization (GO:0007019)2.80881037
106DNA ligation (GO:0006266)2.78830377
107maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.78708558
108DNA replication checkpoint (GO:0000076)2.75867451
109regulation of mitotic spindle organization (GO:0060236)2.74906753
110histone H2A acetylation (GO:0043968)2.74248392
111translesion synthesis (GO:0019985)2.74200580
112negative regulation of mRNA processing (GO:0050686)2.73789087
113IMP metabolic process (GO:0046040)2.73290057
114viral mRNA export from host cell nucleus (GO:0046784)2.72485698
115DNA packaging (GO:0006323)2.72405170
116neuron cell-cell adhesion (GO:0007158)2.62542818
117retinal ganglion cell axon guidance (GO:0031290)2.58448818
118microtubule polymerization or depolymerization (GO:0031109)2.56678677
119mitotic spindle organization (GO:0007052)2.52324592
120regulation of mitotic spindle checkpoint (GO:1903504)2.49761239
121regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.49761239
122centriole replication (GO:0007099)2.48322156
123DNA damage response, detection of DNA damage (GO:0042769)2.46687637
124V(D)J recombination (GO:0033151)2.46463670
125regulation of helicase activity (GO:0051095)2.46267061
126postsynaptic membrane organization (GO:0001941)2.37632979
127L-serine metabolic process (GO:0006563)2.37484798
128intraciliary transport (GO:0042073)2.36045086
129nonmotile primary cilium assembly (GO:0035058)2.35111036
130microtubule anchoring (GO:0034453)2.32727723
131axonal fasciculation (GO:0007413)2.28621438

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.91177552
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.86725713
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.69391632
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.67988349
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.54987959
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.36458354
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.31600057
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.05839689
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.54646789
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.49302267
11* E2F1_21310950_ChIP-Seq_MCF-7_Human2.45609407
12IGF1R_20145208_ChIP-Seq_DFB_Human2.44440993
13AR_21909140_ChIP-Seq_LNCAP_Human2.42849880
14ZNF274_21170338_ChIP-Seq_K562_Hela2.26052408
15* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.23360484
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.22660291
17GBX2_23144817_ChIP-Seq_PC3_Human2.20584053
18* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.14979086
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.12749729
20* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10375491
21TAF15_26573619_Chip-Seq_HEK293_Human2.08600523
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.08357768
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05687539
24NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.03917418
25ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.01686658
26ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00252430
27E2F7_22180533_ChIP-Seq_HELA_Human10.9626868
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.94383344
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.92047510
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90365335
31SOX2_18555785_ChIP-Seq_MESCs_Mouse1.89574159
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.89502580
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.86707256
34* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82784412
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.75258620
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74031202
37* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69524396
38* EST1_17652178_ChIP-ChIP_JURKAT_Human1.69431887
39* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69208662
40P300_19829295_ChIP-Seq_ESCs_Human1.67305774
41ELK1_19687146_ChIP-ChIP_HELA_Human1.66172244
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61310324
43* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59652351
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56580892
45EZH2_22144423_ChIP-Seq_EOC_Human1.55322736
46XRN2_22483619_ChIP-Seq_HELA_Human1.54925243
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50761817
48E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.50228014
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50120387
50PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.46891246
51FUS_26573619_Chip-Seq_HEK293_Human1.45219732
52* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.43703069
53PADI4_21655091_ChIP-ChIP_MCF-7_Human1.43514376
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42211988
55* EWS_26573619_Chip-Seq_HEK293_Human1.41677375
56TTF2_22483619_ChIP-Seq_HELA_Human1.41370460
57* SOX2_16153702_ChIP-ChIP_HESCs_Human1.40034422
58VDR_22108803_ChIP-Seq_LS180_Human1.39206935
59ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39205511
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.37970382
61* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37669729
62SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.36952809
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35785650
64CIITA_25753668_ChIP-Seq_RAJI_Human1.33834662
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33302647
66* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32817640
67IRF1_19129219_ChIP-ChIP_H3396_Human1.31405818
68* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29242805
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28566494
70SMAD4_21799915_ChIP-Seq_A2780_Human1.28179932
71* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25612838
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.24962173
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.24430916
74* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24313355
75PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23189937
76RNF2_27304074_Chip-Seq_NSC_Mouse1.22495123
77GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21487868
78* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21475018
79* SMAD3_21741376_ChIP-Seq_EPCs_Human1.19509730
80* NANOG_21062744_ChIP-ChIP_HESCs_Human1.18764862
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18457332
82KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17052412
83GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16566433
84* NANOG_16153702_ChIP-ChIP_HESCs_Human1.16481760
85E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16294272
86VDR_23849224_ChIP-Seq_CD4+_Human1.16251391
87TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15883418
88SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14638552
89ETS1_20019798_ChIP-Seq_JURKAT_Human1.12920777
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12798551
91FOXP3_21729870_ChIP-Seq_TREG_Human1.11473969
92SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11151263
93TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10268181
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10268181
95FLI1_27457419_Chip-Seq_LIVER_Mouse1.08944589
96KDM5A_27292631_Chip-Seq_BREAST_Human1.07462333
97DCP1A_22483619_ChIP-Seq_HELA_Human1.07305340
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05669386
99* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05516247
100* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05183590
101FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04926584
102CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04408357
103TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03767074
104TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03600828
105STAT3_23295773_ChIP-Seq_U87_Human1.03599661
106* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03217980
107HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02353183
108* GABP_19822575_ChIP-Seq_HepG2_Human1.01406665
109UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01037187
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.99580942
111CBP_20019798_ChIP-Seq_JUKART_Human0.99580942
112PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99230165
113POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.98912008
114GABP_17652178_ChIP-ChIP_JURKAT_Human0.96743991
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96184833
116WT1_19549856_ChIP-ChIP_CCG9911_Human0.95677561
117KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95625972
118FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95430726
119TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94951460
120AR_25329375_ChIP-Seq_VCAP_Human0.94097843
121* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.94041255
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93675094
123NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93460682
124FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91897475
125* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91438158
126NANOG_18555785_Chip-Seq_ESCs_Mouse0.91188313
127KLF5_20875108_ChIP-Seq_MESCs_Mouse0.91181830
128* SOX9_26525672_Chip-Seq_HEART_Mouse0.90430913
129* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90014250
130SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.89849639
131NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.89456906
132ER_23166858_ChIP-Seq_MCF-7_Human0.89298027
133* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89219812
134* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.88899573
135TCF4_23295773_ChIP-Seq_U87_Human0.88265622
136JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.87504381
137GATA4_21415370_ChIP-Seq_HL-1_Mouse0.86783667
138MYC_22102868_ChIP-Seq_BL_Human0.86467734
139ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84408052
140CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84288147
141NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.81302163
142CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.81104868
143* MYC_18940864_ChIP-ChIP_HL60_Human0.80174223
144ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.79599544
145EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.79061068
146SOX17_20123909_ChIP-Seq_XEN_Mouse0.75577596
147POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.75508496
148CHD1_26751641_Chip-Seq_LNCaP_Human0.74537086
149* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.73813869
150ZFP281_18757296_ChIP-ChIP_E14_Mouse0.71868027
151* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.70901833

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.51158341
2MP0003123_paternal_imprinting3.39970205
3MP0003121_genomic_imprinting3.23982523
4MP0003122_maternal_imprinting3.03136775
5MP0008057_abnormal_DNA_replication2.95787215
6MP0003111_abnormal_nucleus_morphology2.86226134
7MP0003077_abnormal_cell_cycle2.61790402
8MP0010030_abnormal_orbit_morphology2.52718075
9MP0000537_abnormal_urethra_morphology2.42331810
10MP0004957_abnormal_blastocyst_morpholog2.41024050
11MP0009053_abnormal_anal_canal2.39554596
12MP0003693_abnormal_embryo_hatching2.26986531
13MP0003787_abnormal_imprinting2.24992152
14MP0002102_abnormal_ear_morphology2.18080485
15MP0008007_abnormal_cellular_replicative2.14882069
16MP0003880_abnormal_central_pattern2.12514860
17MP0008058_abnormal_DNA_repair2.01181070
18MP0003890_abnormal_embryonic-extraembry2.00513299
19MP0008877_abnormal_DNA_methylation2.00395339
20MP0001529_abnormal_vocalization1.94131783
21MP0008932_abnormal_embryonic_tissue1.84694639
22MP0001730_embryonic_growth_arrest1.70230709
23MP0003385_abnormal_body_wall1.69568007
24MP0004197_abnormal_fetal_growth/weight/1.67556173
25MP0003119_abnormal_digestive_system1.66286206
26MP0003937_abnormal_limbs/digits/tail_de1.64157187
27MP0000350_abnormal_cell_proliferation1.63711055
28MP0001293_anophthalmia1.63482218
29MP0003942_abnormal_urinary_system1.63295540
30MP0001672_abnormal_embryogenesis/_devel1.62733714
31MP0005380_embryogenesis_phenotype1.62733714
32MP0006072_abnormal_retinal_apoptosis1.62345361
33MP0000569_abnormal_digit_pigmentation1.61783762
34MP0003567_abnormal_fetal_cardiomyocyte1.61699405
35MP0002084_abnormal_developmental_patter1.60119406
36MP0002085_abnormal_embryonic_tissue1.58295028
37MP0001697_abnormal_embryo_size1.57829253
38MP0003984_embryonic_growth_retardation1.52298324
39MP0001984_abnormal_olfaction1.52057322
40MP0003136_yellow_coat_color1.50804711
41MP0002088_abnormal_embryonic_growth/wei1.50025624
42MP0003115_abnormal_respiratory_system1.46208089
43MP0003941_abnormal_skin_development1.44250200
44MP0000516_abnormal_urinary_system1.42074116
45MP0005367_renal/urinary_system_phenotyp1.42074116
46MP0010352_gastrointestinal_tract_polyps1.40338869
47MP0002234_abnormal_pharynx_morphology1.39914890
48MP0002938_white_spotting1.38777442
49MP0001299_abnormal_eye_distance/1.36383849
50MP0000049_abnormal_middle_ear1.36339295
51MP0005076_abnormal_cell_differentiation1.35177406
52MP0004233_abnormal_muscle_weight1.34559146
53MP0001188_hyperpigmentation1.34217693
54MP0000566_synostosis1.33629753
55MP0003315_abnormal_perineum_morphology1.31991321
56MP0002086_abnormal_extraembryonic_tissu1.31297303
57MP0003755_abnormal_palate_morphology1.30141657
58MP0005248_abnormal_Harderian_gland1.29983235
59MP0003935_abnormal_craniofacial_develop1.28603016
60MP0005253_abnormal_eye_physiology1.27571279
61MP0006276_abnormal_autonomic_nervous1.26247105
62MP0004270_analgesia1.25914482
63MP0009250_abnormal_appendicular_skeleto1.24717210
64MP0002249_abnormal_larynx_morphology1.24299762
65MP0000534_abnormal_ureter_morphology1.21693186
66MP0001177_atelectasis1.21591866
67MP0008789_abnormal_olfactory_epithelium1.20691976
68MP0002080_prenatal_lethality1.18916287
69MP0010307_abnormal_tumor_latency1.18079774
70MP0000428_abnormal_craniofacial_morphol1.17261738
71MP0003861_abnormal_nervous_system1.17140528
72MP0002184_abnormal_innervation1.14106821
73MP0005391_vision/eye_phenotype1.13583107
74MP0009703_decreased_birth_body1.13563217
75MP0002111_abnormal_tail_morphology1.11231483
76MP0002233_abnormal_nose_morphology1.11199744
77MP0002736_abnormal_nociception_after1.10878703
78MP0002009_preneoplasia1.10620176
79MP0001286_abnormal_eye_development1.10275300
80MP0003786_premature_aging1.06342160
81MP0002638_abnormal_pupillary_reflex1.06239549
82MP0004859_abnormal_synaptic_plasticity1.06197704
83MP0005171_absent_coat_pigmentation1.04770754
84MP0003718_maternal_effect1.04061174
85MP0009672_abnormal_birth_weight1.03969887
86MP0002932_abnormal_joint_morphology1.03881806
87MP0000432_abnormal_head_morphology1.03351724
88MP0009697_abnormal_copulation1.02934913
89MP0000955_abnormal_spinal_cord1.02195599
90MP0002116_abnormal_craniofacial_bone1.01344452
91MP0002152_abnormal_brain_morphology1.00835168
92MP0003705_abnormal_hypodermis_morpholog1.00545847
93MP0005499_abnormal_olfactory_system1.00390959
94MP0005394_taste/olfaction_phenotype1.00390959
95MP0002697_abnormal_eye_size0.99081376
96MP0002282_abnormal_trachea_morphology0.98800513
97MP0000647_abnormal_sebaceous_gland0.98663750
98MP0006292_abnormal_olfactory_placode0.97274362
99MP0002114_abnormal_axial_skeleton0.96916266
100MP0002751_abnormal_autonomic_nervous0.96668510
101MP0004808_abnormal_hematopoietic_stem0.93079587
102MP0001486_abnormal_startle_reflex0.90776533
103MP0000631_abnormal_neuroendocrine_gland0.90193397
104MP0002081_perinatal_lethality0.90070064
105MP0001346_abnormal_lacrimal_gland0.89986706
106MP0005187_abnormal_penis_morphology0.89492914
107MP0002557_abnormal_social/conspecific_i0.89244680
108MP0004811_abnormal_neuron_physiology0.88890545
109MP0006054_spinal_hemorrhage0.88611540
110MP0000778_abnormal_nervous_system0.88598424
111MP0005423_abnormal_somatic_nervous0.87638891
112MP0002752_abnormal_somatic_nervous0.86384862
113MP0002109_abnormal_limb_morphology0.86284357
114MP0002396_abnormal_hematopoietic_system0.84719271
115MP0002925_abnormal_cardiovascular_devel0.83773373
116MP0004133_heterotaxia0.83326462
117MP0002734_abnormal_mechanical_nocicepti0.83271330
118MP0009046_muscle_twitch0.83152027
119MP0002177_abnormal_outer_ear0.82112278
120MP0003635_abnormal_synaptic_transmissio0.81621696
121MP0002882_abnormal_neuron_morphology0.80797097
122MP0003943_abnormal_hepatobiliary_system0.80330915
123MP0002092_abnormal_eye_morphology0.79887082
124MP0002653_abnormal_ependyma_morphology0.79392379
125MP0003938_abnormal_ear_development0.77943110
126MP0000313_abnormal_cell_death0.77003225
127MP0001968_abnormal_touch/_nociception0.76732874
128MP0000733_abnormal_muscle_development0.74761388
129MP0005623_abnormal_meninges_morphology0.74386117
130MP0005503_abnormal_tendon_morphology0.73795846
131MP0002160_abnormal_reproductive_system0.71661069
132MP0000266_abnormal_heart_morphology0.71377789
133MP0002210_abnormal_sex_determination0.71176663
134MP0002127_abnormal_cardiovascular_syste0.68078328

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)4.04489332
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.04489332
3Volvulus (HP:0002580)3.45728874
4Cortical dysplasia (HP:0002539)3.45121977
5Abnormality of the labia minora (HP:0012880)3.00615671
6Abnormality of the 4th metacarpal (HP:0010012)2.97687444
7Nephroblastoma (Wilms tumor) (HP:0002667)2.92266356
8Embryonal renal neoplasm (HP:0011794)2.83801662
9Colon cancer (HP:0003003)2.82576007
10Abnormal lung lobation (HP:0002101)2.81605536
11Renal duplication (HP:0000075)2.73457539
12Medulloblastoma (HP:0002885)2.67738492
13Increased nuchal translucency (HP:0010880)2.67537742
14Chromsome breakage (HP:0040012)2.57475452
15Deep philtrum (HP:0002002)2.48153707
16Hepatoblastoma (HP:0002884)2.44356191
17Patellar aplasia (HP:0006443)2.43386801
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.39547550
19Asymmetry of the thorax (HP:0001555)2.38974132
20Ectopic kidney (HP:0000086)2.38941509
21Aplasia/Hypoplasia of the sternum (HP:0006714)2.38245163
22Aplasia/Hypoplasia of the patella (HP:0006498)2.34307282
23Astrocytoma (HP:0009592)2.30368823
24Abnormality of the astrocytes (HP:0100707)2.30368823
25Selective tooth agenesis (HP:0001592)2.29554093
26Aqueductal stenosis (HP:0002410)2.25831583
27Birth length less than 3rd percentile (HP:0003561)2.24729523
28Deviation of the thumb (HP:0009603)2.21741214
29Spinal cord lesions (HP:0100561)2.19943902
30Syringomyelia (HP:0003396)2.19943902
31Drooling (HP:0002307)2.19004483
32Oligodactyly (hands) (HP:0001180)2.18820403
33Septo-optic dysplasia (HP:0100842)2.18375538
34Vaginal atresia (HP:0000148)2.17199912
35Papillary thyroid carcinoma (HP:0002895)2.16834949
36Ependymoma (HP:0002888)2.16442355
37Genital tract atresia (HP:0001827)2.16298423
38Diastasis recti (HP:0001540)2.16288440
39Abnormal number of incisors (HP:0011064)2.15159925
40Abnormality of the preputium (HP:0100587)2.10695107
41Glioma (HP:0009733)2.09972518
42Abnormality of chromosome stability (HP:0003220)2.08937753
43Meckel diverticulum (HP:0002245)2.05171633
44Gait imbalance (HP:0002141)2.04904564
45Abnormality of chromosome segregation (HP:0002916)2.04539665
46Atresia of the external auditory canal (HP:0000413)2.03447421
47Broad thumb (HP:0011304)2.03001040
48Abnormality of the ileum (HP:0001549)2.02987305
49True hermaphroditism (HP:0010459)2.02612235
50Proximal placement of thumb (HP:0009623)2.00767942
51Pancreatic cysts (HP:0001737)2.00207031
52Congenital primary aphakia (HP:0007707)1.99247066
53Impulsivity (HP:0100710)1.99156623
54Abnormality of the anterior horn cell (HP:0006802)1.98591947
55Degeneration of anterior horn cells (HP:0002398)1.98591947
56Sloping forehead (HP:0000340)1.97194598
57Missing ribs (HP:0000921)1.97044024
58Rhabdomyosarcoma (HP:0002859)1.95078589
59Hypoplastic pelvis (HP:0008839)1.94639116
60Rib fusion (HP:0000902)1.94243054
61Oligodactyly (HP:0012165)1.93594571
62Medial flaring of the eyebrow (HP:0010747)1.93263518
63Preaxial hand polydactyly (HP:0001177)1.92230427
64Triphalangeal thumb (HP:0001199)1.92151577
65Duodenal stenosis (HP:0100867)1.91473821
66Small intestinal stenosis (HP:0012848)1.91473821
67Facial hemangioma (HP:0000329)1.90934753
68Midline defect of the nose (HP:0004122)1.90638393
69Broad phalanges of the hand (HP:0009768)1.89471648
70Excessive salivation (HP:0003781)1.88978205
71Supernumerary spleens (HP:0009799)1.87830331
72Nephronophthisis (HP:0000090)1.86879652
73Skull defect (HP:0001362)1.86830270
74Optic nerve hypoplasia (HP:0000609)1.84710561
75Nephrogenic diabetes insipidus (HP:0009806)1.84520086
76High anterior hairline (HP:0009890)1.84224382
77Pancreatic fibrosis (HP:0100732)1.83637271
78Lissencephaly (HP:0001339)1.83404965
79Bifid tongue (HP:0010297)1.83347878
80Gastrointestinal atresia (HP:0002589)1.83235132
81Microglossia (HP:0000171)1.81941717
82Anophthalmia (HP:0000528)1.81608158
83Poor coordination (HP:0002370)1.81385144
84Hypoplastic female external genitalia (HP:0012815)1.81062591
85Subacute progressive viral hepatitis (HP:0006572)1.80712841
86Short 5th finger (HP:0009237)1.80383242
87Tubulointerstitial nephritis (HP:0001970)1.79822302
88Aplasia/Hypoplasia of the uvula (HP:0010293)1.79768538
89Benign neoplasm of the central nervous system (HP:0100835)1.79660722
90Shawl scrotum (HP:0000049)1.79471416
91Micropenis (HP:0000054)1.78936851
92Renal hypoplasia (HP:0000089)1.78913856
93Broad finger (HP:0001500)1.78891633
94Short middle phalanx of the 5th finger (HP:0004220)1.78534246
95Labial hypoplasia (HP:0000066)1.78112986
96Mesomelia (HP:0003027)1.77681384
9711 pairs of ribs (HP:0000878)1.76883943
98Gastrointestinal carcinoma (HP:0002672)1.76481411
99Malignant gastrointestinal tract tumors (HP:0006749)1.76481411
100Absent eyebrow (HP:0002223)1.75177709
101Abnormality of the metopic suture (HP:0005556)1.74705174
102Abnormality of the incisor (HP:0000676)1.74351658
103Cutaneous finger syndactyly (HP:0010554)1.72859191
104Obsessive-compulsive behavior (HP:0000722)1.71135445
105Broad foot (HP:0001769)1.71110915
106Increased number of teeth (HP:0011069)1.70912310
107Abnormality of the nasal septum (HP:0000419)1.70618456
108Dandy-Walker malformation (HP:0001305)1.70358915
109Trigonocephaly (HP:0000243)1.70251484
110Intestinal fistula (HP:0100819)1.69803322
111Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.69412863
112Cutaneous melanoma (HP:0012056)1.69362314
113Neoplasm of striated muscle (HP:0009728)1.69269547
114Esophageal atresia (HP:0002032)1.68808920
115Rectal fistula (HP:0100590)1.68669249
116Rectovaginal fistula (HP:0000143)1.68669249
117Astigmatism (HP:0000483)1.67424383
118Neoplasm of the oral cavity (HP:0100649)1.66934881
119Absent radius (HP:0003974)1.66509297
120Postaxial hand polydactyly (HP:0001162)1.66405325
121Intestinal polyposis (HP:0200008)1.66209469
122Hyperglycinemia (HP:0002154)1.65736729
123Bicornuate uterus (HP:0000813)1.65673969
124Long eyelashes (HP:0000527)1.65456060
125Intestinal atresia (HP:0011100)1.65335121
126Abnormality of the septum pellucidum (HP:0007375)1.65049650
127Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.64799406
128Long clavicles (HP:0000890)1.64692242
129Embryonal neoplasm (HP:0002898)1.64531690
130Broad palm (HP:0001169)1.64070693
131Abnormality of the duodenum (HP:0002246)1.63646192
132Abnormality of the carotid arteries (HP:0005344)1.63030417
133Ovarian neoplasm (HP:0100615)1.62977120
134Broad phalanx (HP:0006009)1.62940395
135Cafe-au-lait spot (HP:0000957)1.62579842
136Abnormality of the parathyroid morphology (HP:0011766)1.62495214
137Bilateral microphthalmos (HP:0007633)1.62120567
138Neoplasm of the adrenal cortex (HP:0100641)1.62097228
139Abnormality of midbrain morphology (HP:0002418)1.62084755
140Molar tooth sign on MRI (HP:0002419)1.62084755
141Intestinal polyp (HP:0005266)1.60556512
142Uterine neoplasm (HP:0010784)1.60273620
143Renovascular hypertension (HP:0100817)1.60271543
144Hemivertebrae (HP:0002937)1.60230701
145Morphological abnormality of the middle ear (HP:0008609)1.59773487
146Specific learning disability (HP:0001328)1.59660671
147Cupped ear (HP:0000378)1.57240602
148Absent septum pellucidum (HP:0001331)1.56900525
149Abnormality of the distal phalanx of the thumb (HP:0009617)1.56565344
150Absent forearm bone (HP:0003953)1.56514588
151Aplasia involving forearm bones (HP:0009822)1.56514588
152Abdominal situs inversus (HP:0003363)1.55424953
153Abnormality of abdominal situs (HP:0011620)1.55424953
154Anencephaly (HP:0002323)1.52330390
155Hyperventilation (HP:0002883)1.51992158
156Pendular nystagmus (HP:0012043)1.51991968

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.55209269
2WNK33.18006682
3MKNK13.16581891
4SRPK12.88732416
5NEK12.64724016
6WEE12.42796082
7PLK32.42557259
8TRIM282.39403864
9BRSK22.33901992
10ERBB32.32513755
11ZAK2.26176087
12MKNK22.17519394
13TSSK62.15064157
14PASK2.12834190
15TNIK2.11970861
16AKT32.08445649
17NEK22.04184652
18BUB12.02613645
19BRSK11.90917594
20TTK1.84121240
21ATR1.81676535
22PLK11.80992216
23CDK121.73387200
24MAP4K21.66624921
25TAF11.66159604
26PLK41.64515514
27EIF2AK11.61931331
28PNCK1.54549997
29MAP2K71.54280672
30CHEK21.53057331
31PLK21.47189724
32LATS11.45642410
33DYRK21.45221612
34CCNB11.44909645
35ACVR1B1.41518039
36BMPR1B1.37244805
37EPHA41.34716939
38VRK21.33553144
39FGFR21.31115786
40STK38L1.30932494
41CHEK11.30041499
42* AURKB1.26722787
43VRK11.24774128
44CSNK1G11.24715459
45TGFBR11.23070004
46ATM1.17913620
47BRD41.17824900
48YES11.17702024
49SGK21.15775275
50CSNK1G21.15416183
51CSNK1A1L1.13842386
52CSNK1G31.12359574
53STK31.12114888
54CDK71.10642733
55KSR11.01068459
56CASK0.99146634
57CDK20.98706744
58PBK0.97280813
59CDK80.97274276
60CDK60.97189683
61FGFR10.95311022
62MELK0.93867666
63CDK10.93128573
64NTRK20.92699298
65STK40.92070069
66STK240.90740931
67RPS6KB10.87262872
68SCYL20.86672436
69DYRK30.84950898
70AURKA0.84105988
71RPS6KB20.82252436
72CDK40.82017017
73PDGFRA0.80647100
74BCR0.79363165
75UHMK10.78973281
76CLK10.77749887
77SGK30.76758878
78EIF2AK20.75763137
79OBSCN0.73600778
80MAPK130.72594844
81LATS20.69727771
82CDK30.65779963
83PKN20.65759746
84SIK30.65313451
85MAP3K80.65245538
86EPHB20.63171631
87ALK0.61740060
88PAK30.61372557
89RPS6KC10.61295999
90RPS6KL10.61295999
91MAP3K100.59875048
92PRKCG0.59137894
93MARK10.59070600
94PRKDC0.58540100
95DAPK10.57476941
96CAMK1G0.57154040
97TLK10.55618669
98MAPK140.55194531
99PAK40.55171463
100MINK10.54799750
101DYRK1A0.52966104
102PRKD30.52538120
103DDR20.52398255
104FRK0.52294035
105CDK180.52103048
106RPS6KA60.48958313
107CSNK1D0.47053931
108RPS6KA40.46625073
109MTOR0.46547028
110INSRR0.46442624
111EEF2K0.44559936
112AKT10.44223254
113CDK150.44086306
114PRKCE0.43800335
115EIF2AK30.43371051
116GSK3B0.42699364
117* CSNK2A10.42548112
118PAK60.40997150
119CDK11A0.40600317
120NUAK10.40523045
121CSNK2A20.40358057
122NEK90.40062497
123SGK2230.39988293
124SGK4940.39988293
125STK390.38864460
126CDK140.38299879
127MAP3K40.38281383
128PKN10.36159786
129CSNK1E0.35288778
130RPS6KA20.35265044
131MAP2K40.34619044
132FLT30.31415356
133EPHA30.31088544
134NLK0.29755454
135OXSR10.29646131

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.16795855
2Mismatch repair_Homo sapiens_hsa034304.02166341
3Cell cycle_Homo sapiens_hsa041103.33482690
4Base excision repair_Homo sapiens_hsa034102.94089891
5RNA transport_Homo sapiens_hsa030132.87548634
6Spliceosome_Homo sapiens_hsa030402.83884514
7Homologous recombination_Homo sapiens_hsa034402.76312501
8Nucleotide excision repair_Homo sapiens_hsa034202.57771882
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.51010150
10mRNA surveillance pathway_Homo sapiens_hsa030152.49679127
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.46557441
12Fanconi anemia pathway_Homo sapiens_hsa034602.38085615
13One carbon pool by folate_Homo sapiens_hsa006702.13268968
14Non-homologous end-joining_Homo sapiens_hsa034502.12327633
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.08664980
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.08417374
17Protein export_Homo sapiens_hsa030602.03820539
18Steroid biosynthesis_Homo sapiens_hsa001001.99460217
19RNA degradation_Homo sapiens_hsa030181.91903426
20Oocyte meiosis_Homo sapiens_hsa041141.81906903
21Basal cell carcinoma_Homo sapiens_hsa052171.75203929
22Propanoate metabolism_Homo sapiens_hsa006401.73716286
23Systemic lupus erythematosus_Homo sapiens_hsa053221.69498477
24Hippo signaling pathway_Homo sapiens_hsa043901.61586477
25Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.60682511
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.51668493
27Basal transcription factors_Homo sapiens_hsa030221.42358113
28MicroRNAs in cancer_Homo sapiens_hsa052061.41867914
29Butanoate metabolism_Homo sapiens_hsa006501.38742725
30Hedgehog signaling pathway_Homo sapiens_hsa043401.36900593
31p53 signaling pathway_Homo sapiens_hsa041151.36291527
32RNA polymerase_Homo sapiens_hsa030201.34084843
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.34057838
34Alcoholism_Homo sapiens_hsa050341.31961432
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27945068
36TGF-beta signaling pathway_Homo sapiens_hsa043501.27535207
37Colorectal cancer_Homo sapiens_hsa052101.26544247
38Pyrimidine metabolism_Homo sapiens_hsa002401.20992293
39Adherens junction_Homo sapiens_hsa045201.20452867
40Endometrial cancer_Homo sapiens_hsa052131.18721997
41Thyroid cancer_Homo sapiens_hsa052161.18051515
42Viral carcinogenesis_Homo sapiens_hsa052031.17973566
43Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.17077350
44Cysteine and methionine metabolism_Homo sapiens_hsa002701.16038803
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11286356
46Wnt signaling pathway_Homo sapiens_hsa043101.09342377
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07510672
48Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07299871
49HTLV-I infection_Homo sapiens_hsa051661.06438113
50Vitamin B6 metabolism_Homo sapiens_hsa007501.01054922
51Phototransduction_Homo sapiens_hsa047440.99010819
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98446581
53Proteasome_Homo sapiens_hsa030500.96833493
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93599444
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90474339
56Fatty acid elongation_Homo sapiens_hsa000620.89551474
57Pyruvate metabolism_Homo sapiens_hsa006200.89348062
58GABAergic synapse_Homo sapiens_hsa047270.85938634
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85292736
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.85260723
61Epstein-Barr virus infection_Homo sapiens_hsa051690.84865268
62Tight junction_Homo sapiens_hsa045300.83878122
63Chronic myeloid leukemia_Homo sapiens_hsa052200.83738472
64Taste transduction_Homo sapiens_hsa047420.82600556
65Small cell lung cancer_Homo sapiens_hsa052220.80518686
66mTOR signaling pathway_Homo sapiens_hsa041500.80387361
67Melanoma_Homo sapiens_hsa052180.79443010
68Non-small cell lung cancer_Homo sapiens_hsa052230.78400640
69Prostate cancer_Homo sapiens_hsa052150.77939008
70Fatty acid metabolism_Homo sapiens_hsa012120.76515484
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75446037
72Purine metabolism_Homo sapiens_hsa002300.75090054
73Melanogenesis_Homo sapiens_hsa049160.73741613
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73199161
75Proteoglycans in cancer_Homo sapiens_hsa052050.72078536
76Glioma_Homo sapiens_hsa052140.70522428
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.70032316
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68945287
79Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68544648
80Axon guidance_Homo sapiens_hsa043600.68332727
81Notch signaling pathway_Homo sapiens_hsa043300.67533236
82Pathways in cancer_Homo sapiens_hsa052000.67207965
83Viral myocarditis_Homo sapiens_hsa054160.67002611
84Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62141159
85Glutamatergic synapse_Homo sapiens_hsa047240.61613332
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60361778
87Carbon metabolism_Homo sapiens_hsa012000.60260627
88Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59776506
89Bladder cancer_Homo sapiens_hsa052190.58889524
90Cocaine addiction_Homo sapiens_hsa050300.58515396
91Long-term potentiation_Homo sapiens_hsa047200.58425359
92Dilated cardiomyopathy_Homo sapiens_hsa054140.58343160
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57979780
94Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57139446
95Lysine degradation_Homo sapiens_hsa003100.54040386
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53751842
97Focal adhesion_Homo sapiens_hsa045100.53380454
98Huntingtons disease_Homo sapiens_hsa050160.52381950
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52237580
100Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51639602
101Herpes simplex infection_Homo sapiens_hsa051680.50485773
102Morphine addiction_Homo sapiens_hsa050320.50381480
103Gap junction_Homo sapiens_hsa045400.48930794
104ErbB signaling pathway_Homo sapiens_hsa040120.48466492
105Pancreatic cancer_Homo sapiens_hsa052120.47524413
106beta-Alanine metabolism_Homo sapiens_hsa004100.47131787
107Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46624530
108FoxO signaling pathway_Homo sapiens_hsa040680.45861839
109N-Glycan biosynthesis_Homo sapiens_hsa005100.45339290
110HIF-1 signaling pathway_Homo sapiens_hsa040660.44063107
111Circadian rhythm_Homo sapiens_hsa047100.42858987
112Neurotrophin signaling pathway_Homo sapiens_hsa047220.42124813
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41728925
114Biosynthesis of amino acids_Homo sapiens_hsa012300.40334492
115Dopaminergic synapse_Homo sapiens_hsa047280.39936427
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38269342
117Hepatitis B_Homo sapiens_hsa051610.38043464
118Parkinsons disease_Homo sapiens_hsa050120.36431356
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34478021
120Nicotine addiction_Homo sapiens_hsa050330.34212345
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.33776376
1222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33549548
123Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.32966527
124Amphetamine addiction_Homo sapiens_hsa050310.32867550
125Rap1 signaling pathway_Homo sapiens_hsa040150.31920279
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31223112
127Estrogen signaling pathway_Homo sapiens_hsa049150.30512971
128Long-term depression_Homo sapiens_hsa047300.29993988
129Folate biosynthesis_Homo sapiens_hsa007900.29990657
130Insulin secretion_Homo sapiens_hsa049110.29099024
131Glucagon signaling pathway_Homo sapiens_hsa049220.28806994
132Metabolic pathways_Homo sapiens_hsa011000.28794382
133Insulin signaling pathway_Homo sapiens_hsa049100.28778789
134Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27527648
135cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27452520
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27303945
137Serotonergic synapse_Homo sapiens_hsa047260.27159449
138Tryptophan metabolism_Homo sapiens_hsa003800.26273039
139Ether lipid metabolism_Homo sapiens_hsa005650.26130671
140MAPK signaling pathway_Homo sapiens_hsa040100.25183618
141Selenocompound metabolism_Homo sapiens_hsa004500.24774970
142Renal cell carcinoma_Homo sapiens_hsa052110.21627076
143Circadian entrainment_Homo sapiens_hsa047130.21332879
144Olfactory transduction_Homo sapiens_hsa047400.21296482

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