CBX4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)4.19468375
2central nervous system myelination (GO:0022010)4.19468375
3negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.00697701
4negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.00129930
5negative regulation of cell killing (GO:0031342)4.00129930
6positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.94395217
7mannose metabolic process (GO:0006013)3.79652146
8response to muramyl dipeptide (GO:0032495)3.73149905
9regulation of NFAT protein import into nucleus (GO:0051532)3.67394603
10neuron cell-cell adhesion (GO:0007158)3.55221392
11response to laminar fluid shear stress (GO:0034616)3.48794295
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.48680498
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.48680498
14positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.47572926
15response to peptidoglycan (GO:0032494)3.44182126
16positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.40657455
17mating behavior (GO:0007617)3.39191569
18positive regulation of gamma-delta T cell activation (GO:0046645)3.36741620
19nerve growth factor signaling pathway (GO:0038180)3.31573899
20modulation by virus of host process (GO:0019054)3.23258238
21G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.21495595
22regulation of gamma-delta T cell differentiation (GO:0045586)3.19173352
23macrophage activation involved in immune response (GO:0002281)3.17533677
24apoptotic process involved in morphogenesis (GO:0060561)3.15459055
253-UTR-mediated mRNA stabilization (GO:0070935)3.13730763
26embryonic process involved in female pregnancy (GO:0060136)3.11380919
27modulation by symbiont of host cellular process (GO:0044068)3.11166027
28dendritic spine morphogenesis (GO:0060997)3.09380053
29presynaptic membrane assembly (GO:0097105)3.09307052
30positive regulation of Rap GTPase activity (GO:0032854)3.07847050
31activation of MAPKKK activity (GO:0000185)3.06293344
32regulation of mammary gland epithelial cell proliferation (GO:0033599)3.06074468
33positive T cell selection (GO:0043368)3.05111953
34regulation of Rap GTPase activity (GO:0032317)3.04742463
35antigen processing and presentation of endogenous antigen (GO:0019883)3.01352012
36positive regulation by symbiont of host defense response (GO:0052509)3.00661321
37modulation by symbiont of host defense response (GO:0052031)3.00661321
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.00661321
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.00661321
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.00661321
41modulation by symbiont of host immune response (GO:0052553)3.00661321
42regulation of type I interferon-mediated signaling pathway (GO:0060338)2.99675100
43leukocyte aggregation (GO:0070486)2.98594584
44locomotory exploration behavior (GO:0035641)2.97206199
45vocalization behavior (GO:0071625)2.96680614
46regulation of histone H3-K27 methylation (GO:0061085)2.95429783
47cellular response to virus (GO:0098586)2.90273770
48germinal center formation (GO:0002467)2.88269047
49regulation of chromatin binding (GO:0035561)2.87591137
50regulation of ARF protein signal transduction (GO:0032012)2.84946137
51presynaptic membrane organization (GO:0097090)2.84869258
52neuronal action potential propagation (GO:0019227)2.83895072
53synaptic vesicle maturation (GO:0016188)2.82985188
54negative regulation of viral release from host cell (GO:1902187)2.82678213
55regulation of short-term neuronal synaptic plasticity (GO:0048172)2.80256239
56positive regulation of Cdc42 GTPase activity (GO:0043089)2.79629890
57T cell selection (GO:0045058)2.78874676
58regulation of synaptic vesicle exocytosis (GO:2000300)2.76980986
59response to interleukin-15 (GO:0070672)2.76151003
60intracellular estrogen receptor signaling pathway (GO:0030520)2.74296193
61epithelial cell differentiation involved in prostate gland development (GO:0060742)2.73330735
62gamma-aminobutyric acid transport (GO:0015812)2.72939134
63activated T cell proliferation (GO:0050798)2.72239972
64regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.72089611
65myelin maintenance (GO:0043217)2.71903511
66protein localization to synapse (GO:0035418)2.71483152
67regulation of gamma-delta T cell activation (GO:0046643)2.70901505
68regulation of early endosome to late endosome transport (GO:2000641)2.70416778
69gamma-aminobutyric acid signaling pathway (GO:0007214)2.70265114
70axon ensheathment (GO:0008366)2.68269479
71ensheathment of neurons (GO:0007272)2.68269479
72positive regulation of protein deacetylation (GO:0090312)2.67825988
73myelination (GO:0042552)2.67080370
74negative regulation of neurotransmitter transport (GO:0051589)2.66568297
75negative T cell selection (GO:0043383)2.66132058
76lipopolysaccharide-mediated signaling pathway (GO:0031663)2.65071541
77regulation of ARF GTPase activity (GO:0032312)2.64920894
78positive regulation of keratinocyte differentiation (GO:0045618)2.64541097
79activation of Rac GTPase activity (GO:0032863)2.63404108
80ionotropic glutamate receptor signaling pathway (GO:0035235)2.62945312
81negative regulation of neurotransmitter secretion (GO:0046929)2.59493828
82transmission of nerve impulse (GO:0019226)2.58913395
83synaptic vesicle exocytosis (GO:0016079)2.58414927
84thymic T cell selection (GO:0045061)2.58348074
85positive thymic T cell selection (GO:0045059)2.58070081
86regulation of T-helper 2 cell differentiation (GO:0045628)2.57626310
87interferon-gamma secretion (GO:0072643)2.56944328
88layer formation in cerebral cortex (GO:0021819)2.56623657
89positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.56180761
90regulation of histone deacetylation (GO:0031063)2.55169836
91cellular potassium ion homeostasis (GO:0030007)2.54965692
92positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.54537074
93regulation of long-term neuronal synaptic plasticity (GO:0048169)2.53027874
94negative thymic T cell selection (GO:0045060)2.51916845
95Golgi to endosome transport (GO:0006895)2.51859914
96positive regulation of protein homooligomerization (GO:0032464)2.51746795
97positive regulation of CREB transcription factor activity (GO:0032793)2.51704993
98neuron recognition (GO:0008038)2.49759776
99protein localization to endosome (GO:0036010)2.49695841
100negative regulation of erythrocyte differentiation (GO:0045647)2.49322089
101mast cell activation involved in immune response (GO:0002279)2.48786575
102mast cell degranulation (GO:0043303)2.48786575
103regulation of dendritic spine morphogenesis (GO:0061001)2.48681842
104regulation of glutamate receptor signaling pathway (GO:1900449)2.48458630
105regulation of regulatory T cell differentiation (GO:0045589)2.48189269
106regulation of interferon-beta biosynthetic process (GO:0045357)2.47480412
107NIK/NF-kappaB signaling (GO:0038061)2.47412278
108regulation of neuronal synaptic plasticity (GO:0048168)2.47321371
109response to type I interferon (GO:0034340)2.45668842
110type I interferon signaling pathway (GO:0060337)2.44445202
111cellular response to type I interferon (GO:0071357)2.44445202
112detection of other organism (GO:0098543)2.44123673
113positive regulation of membrane potential (GO:0045838)2.43376466
114detection of bacterium (GO:0016045)2.42924847
115neutrophil activation involved in immune response (GO:0002283)2.42279810
116lipid translocation (GO:0034204)2.42041054
117phospholipid translocation (GO:0045332)2.42041054
118adherens junction assembly (GO:0034333)2.42010888
119negative regulation of toll-like receptor signaling pathway (GO:0034122)2.41051040
120regulation of dendritic spine development (GO:0060998)2.39797724
121negative regulation of bone resorption (GO:0045779)2.39093810
122regulation of glucose import in response to insulin stimulus (GO:2001273)2.38963291
123negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.38256960
124negative regulation of fatty acid transport (GO:2000192)2.38214593
125regulation of fatty acid beta-oxidation (GO:0031998)2.38130712
126serine transport (GO:0032329)2.37027881
127negative regulation of synaptic transmission, GABAergic (GO:0032229)2.36596575
128Peyers patch development (GO:0048541)2.36452606
129mucosal-associated lymphoid tissue development (GO:0048537)2.36452606
130regulation of excitatory postsynaptic membrane potential (GO:0060079)2.35923254
131L-serine transport (GO:0015825)2.35892665
132histone H3-K36 demethylation (GO:0070544)2.35759843
133tolerance induction (GO:0002507)2.34836668
134glutamate receptor signaling pathway (GO:0007215)2.33880532
135B cell receptor signaling pathway (GO:0050853)2.33493285
136regulation of viral release from host cell (GO:1902186)2.33225736
137response to nerve growth factor (GO:1990089)2.32235447
138cellular response to nerve growth factor stimulus (GO:1990090)2.32235447
139negative regulation of interleukin-8 production (GO:0032717)2.31284415
140regulation of defense response to virus by virus (GO:0050690)2.31120914
141mast cell activation (GO:0045576)2.30992211
142regulation of apoptotic process involved in morphogenesis (GO:1902337)2.29922012
143maternal placenta development (GO:0001893)2.29359811
144oligodendrocyte differentiation (GO:0048709)2.28241090
145long-term memory (GO:0007616)2.27719596
146T cell receptor signaling pathway (GO:0050852)2.27627685
147regulation of synaptic vesicle transport (GO:1902803)2.27576852
148negative regulation of myeloid cell apoptotic process (GO:0033033)2.27484087
149poly(A)+ mRNA export from nucleus (GO:0016973)2.27466000
150regulation of leukocyte degranulation (GO:0043300)2.27235381
151focal adhesion assembly (GO:0048041)2.27169623
152cell-substrate adherens junction assembly (GO:0007045)2.27169623
153T cell homeostasis (GO:0043029)2.27066955
154negative regulation of inclusion body assembly (GO:0090084)2.26710103
155cell-cell junction maintenance (GO:0045217)2.25761451
156glutamate secretion (GO:0014047)2.25661697
157negative regulation of granulocyte differentiation (GO:0030853)2.25235878
158antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.25060345
159spliceosomal tri-snRNP complex assembly (GO:0000244)2.24992464
160activation of protein kinase A activity (GO:0034199)2.24502696
161neurotransmitter secretion (GO:0007269)2.24411775
162regulation of necroptotic process (GO:0060544)2.24337087
163peptidyl-tyrosine autophosphorylation (GO:0038083)2.24273094
164activation of JUN kinase activity (GO:0007257)2.24154555
165negative regulation of interleukin-6 production (GO:0032715)2.24152039
166sodium ion export (GO:0071436)2.24040869
167negative regulation of cell size (GO:0045792)2.23922330
168mammary gland epithelial cell differentiation (GO:0060644)2.23685351
169positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.23681916
170cellular response to interleukin-15 (GO:0071350)2.23654227
171CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.23543912
172positive regulation of histone deacetylation (GO:0031065)2.22745128
173cerebellar Purkinje cell differentiation (GO:0021702)2.22646854
174negative regulation of interleukin-12 production (GO:0032695)2.22581386
175regulation of synapse structural plasticity (GO:0051823)2.22538944
176negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.22463156
177myeloid dendritic cell differentiation (GO:0043011)2.21770695
178regulation of monocyte differentiation (GO:0045655)2.21747415
179trophectodermal cell differentiation (GO:0001829)2.21526451
180regulation of postsynaptic membrane potential (GO:0060078)2.21118301
181antigen receptor-mediated signaling pathway (GO:0050851)2.19844278
182exploration behavior (GO:0035640)2.18265710
183cellular response to catecholamine stimulus (GO:0071870)2.17008895

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.02200173
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.96201644
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.67815317
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.56243440
5* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.52113974
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.47722069
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.47009810
8* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.37784573
9* ELK3_25401928_ChIP-Seq_HUVEC_Human2.36125533
10VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.34961128
11* RACK7_27058665_Chip-Seq_MCF-7_Human2.30570082
12* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.24857823
13DROSHA_22980978_ChIP-Seq_HELA_Human2.24006077
14* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.22682366
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.18247941
16* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11603391
17* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11603391
18* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.06761481
19IKZF1_21737484_ChIP-ChIP_HCT116_Human2.06104939
20* RARB_27405468_Chip-Seq_BRAIN_Mouse2.03997607
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01843898
22* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.96952911
23* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.95018893
24* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.92391724
25RUNX_20019798_ChIP-Seq_JUKART_Human1.89423748
26AR_21572438_ChIP-Seq_LNCaP_Human1.86412229
27ZNF263_19887448_ChIP-Seq_K562_Human1.86207915
28* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.84718638
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.84142479
30* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.83191521
31* EZH2_27294783_Chip-Seq_ESCs_Mouse1.78402335
32* MAF_26560356_Chip-Seq_TH2_Human1.78137368
33* RNF2_27304074_Chip-Seq_ESCs_Mouse1.73834761
34* EZH2_27304074_Chip-Seq_ESCs_Mouse1.67353380
35* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66014621
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65908119
37GBX2_23144817_ChIP-Seq_PC3_Human1.63932454
38* KDM2B_26808549_Chip-Seq_DND41_Human1.63687322
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.62763225
40CREB1_26743006_Chip-Seq_LNCaP_Human1.62090220
41IRF8_22096565_ChIP-ChIP_GC-B_Human1.62022189
42TAF15_26573619_Chip-Seq_HEK293_Human1.59752723
43* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.58226872
44* P68_20966046_ChIP-Seq_HELA_Human1.58224907
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.57369948
46* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55868329
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.54519178
48SA1_27219007_Chip-Seq_ERYTHROID_Human1.49351220
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.49221516
50TCF7_22412390_ChIP-Seq_EML_Mouse1.47688434
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.45399210
52* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.43572320
53* KDM2B_26808549_Chip-Seq_JURKAT_Human1.42876732
54* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42735889
55SCL_19346495_ChIP-Seq_HPC-7_Human1.42561358
56* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42163347
57* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.41690359
58NCOR1_26117541_ChIP-Seq_K562_Human1.40840037
59* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40416672
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.39561719
61* EED_16625203_ChIP-ChIP_MESCs_Mouse1.39390643
62* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.39046134
63TET1_21451524_ChIP-Seq_MESCs_Mouse1.38583099
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.34816517
65* RUNX1_27514584_Chip-Seq_MCF-7_Human1.33684628
66* VDR_21846776_ChIP-Seq_THP-1_Human1.33544682
67KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33301118
68TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33268624
69* ATF3_27146783_Chip-Seq_COLON_Human1.33187964
70* KDM2B_26808549_Chip-Seq_K562_Human1.32993223
71* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32363451
72REST_21632747_ChIP-Seq_MESCs_Mouse1.31006456
73PKCTHETA_26484144_Chip-Seq_BREAST_Human1.30864910
74* SMC4_20622854_ChIP-Seq_HELA_Human1.29351747
75* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28385731
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.27716996
77UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.27704541
78EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27660080
79* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26966767
80STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26048799
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.25645030
82* VDR_24763502_ChIP-Seq_THP-1_Human1.24811934
83MYC_22102868_ChIP-Seq_BL_Human1.22934988
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22614225
85CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.22034842
86WT1_19549856_ChIP-ChIP_CCG9911_Human1.21312463
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20553576
88P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20029080
89* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.19170955
90AHR_22903824_ChIP-Seq_MCF-7_Human1.18887685
91MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.18852396
92ELF1_20517297_ChIP-Seq_JURKAT_Human1.18784167
93RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.17582790
94* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16257794
95GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15286556
96* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14426117
97TP53_16413492_ChIP-PET_HCT116_Human1.13302610
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.13155453
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12900501
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.12669652
101E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12428597
102RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12167541
103REST_18959480_ChIP-ChIP_MESCs_Mouse1.11140527
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10409621
105MAF_26560356_Chip-Seq_TH1_Human1.10145487
106THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09802026
107BCOR_27268052_Chip-Seq_Bcells_Human1.09566920
108* RING1B_27294783_Chip-Seq_ESCs_Mouse1.07583313
109CTBP1_25329375_ChIP-Seq_LNCAP_Human1.07556437
110GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06362943
111GATA1_19941827_ChIP-Seq_MEL_Mouse1.06177691
112* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.06101256
113SMAD_19615063_ChIP-ChIP_OVARY_Human1.05632223
114* UTX_26944678_Chip-Seq_JUKART_Human1.05066975
115SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05059008
116* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.03885722
117TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03747289
118NR3C1_23031785_ChIP-Seq_PC12_Mouse1.03687523
119* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02690741
120ARNT_22903824_ChIP-Seq_MCF-7_Human1.02505753
121CIITA_25753668_ChIP-Seq_RAJI_Human1.01884587
122SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01763265
123* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00793432
124MYB_26560356_Chip-Seq_TH2_Human1.00075805
125RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00028028
126MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99636703
127SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99222828
128CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98914714
129BCL6_27268052_Chip-Seq_Bcells_Human0.98638191
130SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98340678
131KLF4_18555785_ChIP-Seq_MESCs_Mouse0.98280398
132* PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96993984
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96899333
134* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95640020
135LXR_22292898_ChIP-Seq_THP-1_Human0.95319381
136* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94893122
137STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94853979
138NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.94806386
139PPARA_22158963_ChIP-Seq_LIVER_Mouse0.94731655
140CTCF_21964334_ChIP-Seq_BJAB-B_Human0.94335642
141SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93967428
142ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93855624
143SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93622210
144CTCF_26484167_Chip-Seq_Bcells_Mouse0.93252837
145SPI1_23547873_ChIP-Seq_NB4_Human0.93043416
146UBF1/2_26484160_Chip-Seq_HMECs_Human0.92834606
147* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92241558
148* RING1B_27294783_Chip-Seq_NPCs_Mouse0.89034100
149PRDM14_20953172_ChIP-Seq_ESCs_Human0.88282002
150GATA3_27048872_Chip-Seq_THYMUS_Human0.87687426
151TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.87248921
152GATA1_19941826_ChIP-Seq_K562_Human0.85950650
153CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85805739
154NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85217188
155ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.84847567
156SPI1_23127762_ChIP-Seq_K562_Human0.84668742
157MYB_21317192_ChIP-Seq_ERMYB_Mouse0.84279376
158P53_22127205_ChIP-Seq_FIBROBLAST_Human0.84226263
159SMAD3_21741376_ChIP-Seq_EPCs_Human0.83732354
160VDR_24787735_ChIP-Seq_THP-1_Human0.83558220
161* RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.82785679
162IRF8_27001747_Chip-Seq_BMDM_Mouse0.79481063
163DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.78345302
164TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.78106320
165* SMAD4_21799915_ChIP-Seq_A2780_Human0.78056571
166SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.77967405
167* RXR_22108803_ChIP-Seq_LS180_Human0.77321858
168MYB_26560356_Chip-Seq_TH1_Human0.76576909

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.21229619
2MP0004859_abnormal_synaptic_plasticity3.87104502
3MP0005076_abnormal_cell_differentiation3.25011938
4MP0003635_abnormal_synaptic_transmissio2.97889522
5MP0005451_abnormal_body_composition2.95126554
6MP0003705_abnormal_hypodermis_morpholog2.63274186
7MP0005423_abnormal_somatic_nervous2.62450296
8MP0004185_abnormal_adipocyte_glucose2.57526128
9MP0003329_amyloid_beta_deposits2.53743223
10MP0000920_abnormal_myelination2.50497712
11MP0003303_peritoneal_inflammation2.50228034
12MP0003172_abnormal_lysosome_physiology2.49891584
13MP0004270_analgesia2.44213001
14MP0002822_catalepsy2.41380060
15MP0009745_abnormal_behavioral_response2.35313568
16MP0005058_abnormal_lysosome_morphology2.34618391
17MP0001501_abnormal_sleep_pattern2.32873465
18MP0005409_darkened_coat_color2.29554813
19MP0002064_seizures2.27770492
20MP0008260_abnormal_autophagy2.26146009
21MP0002272_abnormal_nervous_system2.08941506
22MP0002063_abnormal_learning/memory/cond2.05943690
23MP0001486_abnormal_startle_reflex2.02906661
24MP0010234_abnormal_vibrissa_follicle2.01956102
25MP0003763_abnormal_thymus_physiology1.92073738
26MP0009333_abnormal_splenocyte_physiolog1.91273257
27MP0003300_gastrointestinal_ulcer1.87692782
28MP0005666_abnormal_adipose_tissue1.83935187
29MP0008569_lethality_at_weaning1.79679982
30MP0004742_abnormal_vestibular_system1.78619281
31MP0002249_abnormal_larynx_morphology1.78232014
32MP0001984_abnormal_olfaction1.75858222
33MP0002572_abnormal_emotion/affect_behav1.72192217
34MP0004381_abnormal_hair_follicle1.71896908
35MP0004858_abnormal_nervous_system1.66649349
36MP0003123_paternal_imprinting1.64873500
37MP0009840_abnormal_foam_cell1.62676645
38MP0001968_abnormal_touch/_nociception1.61158375
39MP0001835_abnormal_antigen_presentation1.60519432
40MP0000685_abnormal_immune_system1.57352184
41MP0000678_abnormal_parathyroid_gland1.56483204
42MP0002877_abnormal_melanocyte_morpholog1.55455997
43MP0005645_abnormal_hypothalamus_physiol1.51579437
44MP0009780_abnormal_chondrocyte_physiolo1.50991095
45MP0004264_abnormal_extraembryonic_tissu1.46278988
46MP0002166_altered_tumor_susceptibility1.46221054
47MP0008874_decreased_physiological_sensi1.44839012
48MP0001790_abnormal_immune_system1.43904437
49MP0005387_immune_system_phenotype1.43904437
50MP0008961_abnormal_basal_metabolism1.43640049
51MP0005375_adipose_tissue_phenotype1.43277526
52MP0000604_amyloidosis1.42538797
53MP0000858_altered_metastatic_potential1.42408567
54MP0001800_abnormal_humoral_immune1.42239420
55MP0004808_abnormal_hematopoietic_stem1.42006869
56MP0009046_muscle_twitch1.40613357
57MP0005671_abnormal_response_to1.39815844
58MP0001502_abnormal_circadian_rhythm1.38700118
59MP0003866_abnormal_defecation1.36154919
60MP0010678_abnormal_skin_adnexa1.34793566
61MP0002396_abnormal_hematopoietic_system1.32275771
62MP0002909_abnormal_adrenal_gland1.31207507
63MP0004510_myositis1.28832946
64MP0003091_abnormal_cell_migration1.27511711
65MP0003690_abnormal_glial_cell1.26950923
66MP0002557_abnormal_social/conspecific_i1.25602995
67MP0002098_abnormal_vibrissa_morphology1.24022265
68MP0001851_eye_inflammation1.23726581
69MP0005000_abnormal_immune_tolerance1.23244774
70MP0002735_abnormal_chemical_nociception1.22011739
71MP0002734_abnormal_mechanical_nocicepti1.21039019
72MP0001970_abnormal_pain_threshold1.20618862
73MP0001533_abnormal_skeleton_physiology1.20378599
74MP0002067_abnormal_sensory_capabilities1.19768448
75MP0002148_abnormal_hypersensitivity_rea1.19056614
76MP0002420_abnormal_adaptive_immunity1.18190133
77MP0002733_abnormal_thermal_nociception1.17728664
78MP0002722_abnormal_immune_system1.16081838
79MP0001346_abnormal_lacrimal_gland1.15322762
80MP0002184_abnormal_innervation1.15211982
81MP0009785_altered_susceptibility_to1.14712525
82MP0003191_abnormal_cellular_cholesterol1.14469202
83MP0001819_abnormal_immune_cell1.14037691
84MP0003633_abnormal_nervous_system1.13405325
85MP0005386_behavior/neurological_phenoty1.13343296
86MP0004924_abnormal_behavior1.13343296
87MP0001440_abnormal_grooming_behavior1.12917472
88MP0001905_abnormal_dopamine_level1.12828056
89MP0002723_abnormal_immune_serum1.12256344
90MP0003724_increased_susceptibility_to1.10572794
91MP0004885_abnormal_endolymph1.10397965
92MP0005501_abnormal_skin_physiology1.09641526
93MP0000778_abnormal_nervous_system1.09218857
94MP0002429_abnormal_blood_cell1.08533880
95MP0001348_abnormal_lacrimal_gland1.06081208
96MP0002452_abnormal_antigen_presenting1.05305727
97MP0001529_abnormal_vocalization1.04694570
98MP0002405_respiratory_system_inflammati1.04153397
99MP0000465_gastrointestinal_hemorrhage1.03340398
100MP0005310_abnormal_salivary_gland1.03194988
101MP0000703_abnormal_thymus_morphology1.02762313
102MP0005174_abnormal_tail_pigmentation1.02294023
103MP0003075_altered_response_to1.01986514
104MP0002736_abnormal_nociception_after1.01549027
105MP0001545_abnormal_hematopoietic_system0.99760028
106MP0005397_hematopoietic_system_phenotyp0.99760028
107MP0010155_abnormal_intestine_physiology0.99554696
108MP0004811_abnormal_neuron_physiology0.98737324
109MP0002398_abnormal_bone_marrow0.98146820
110MP0000537_abnormal_urethra_morphology0.97942891
111MP0001216_abnormal_epidermal_layer0.97300675
112MP0001853_heart_inflammation0.96526826
113MP0009931_abnormal_skin_appearance0.96487390
114MP0000955_abnormal_spinal_cord0.96423178
115MP0000716_abnormal_immune_system0.96026478
116MP0002882_abnormal_neuron_morphology0.94657750
117MP0001873_stomach_inflammation0.94641436
118MP0006082_CNS_inflammation0.94579860
119MP0000689_abnormal_spleen_morphology0.93622444
120MP0004947_skin_inflammation0.93033117
121MP0002066_abnormal_motor_capabilities/c0.92965672
122MP0002009_preneoplasia0.90093350
123MP0006276_abnormal_autonomic_nervous0.89534178
124MP0002229_neurodegeneration0.89457941
125MP0003634_abnormal_glial_cell0.88734053
126MP0002089_abnormal_postnatal_growth/wei0.87086434
127MP0002998_abnormal_bone_remodeling0.85900829
128MP0005464_abnormal_platelet_physiology0.84879860
129MP0001845_abnormal_inflammatory_respons0.84475311
130MP0000733_abnormal_muscle_development0.82820391
131MP0005535_abnormal_body_temperature0.81977913
132MP0000013_abnormal_adipose_tissue0.80838904
133MP0000003_abnormal_adipose_tissue0.80499558
134MP0005621_abnormal_cell_physiology0.79518171
135MP0008872_abnormal_physiological_respon0.78393983
136MP0005623_abnormal_meninges_morphology0.77942296
137MP0003631_nervous_system_phenotype0.77655444
138MP0004142_abnormal_muscle_tone0.77575328
139MP0005670_abnormal_white_adipose0.77511580
140MP0003183_abnormal_peptide_metabolism0.77393506
141MP0002006_tumorigenesis0.77369254
142MP0002419_abnormal_innate_immunity0.77162832
143MP0003436_decreased_susceptibility_to0.76883000
144MP0001485_abnormal_pinna_reflex0.76371080
145MP0001919_abnormal_reproductive_system0.75280487
146MP0009278_abnormal_bone_marrow0.75091419
147MP0000383_abnormal_hair_follicle0.72746056
148MP0002796_impaired_skin_barrier0.72266283
149MP0005025_abnormal_response_to0.71857150
150MP0003453_abnormal_keratinocyte_physiol0.71627601
151MP0000490_abnormal_crypts_of0.71444917
152MP0008469_abnormal_protein_level0.71410239
153MP0004233_abnormal_muscle_weight0.71388188
154MP0003566_abnormal_cell_adhesion0.71301696
155MP0000681_abnormal_thyroid_gland0.70793955
156MP0009115_abnormal_fat_cell0.70124447
157MP0002970_abnormal_white_adipose0.69862942
158MP0000470_abnormal_stomach_morphology0.69047015
159MP0004883_abnormal_blood_vessel0.68941086
160MP0001849_ear_inflammation0.68160023
161MP0005166_decreased_susceptibility_to0.66523724

Predicted human phenotypes

RankGene SetZ-score
1Chronic otitis media (HP:0000389)4.00605816
2Focal motor seizures (HP:0011153)3.98129221
3Neurofibrillary tangles (HP:0002185)3.94807713
4Supranuclear gaze palsy (HP:0000605)3.94492656
5Cerebral inclusion bodies (HP:0100314)3.48954033
6Visual hallucinations (HP:0002367)3.47591453
7Eczematoid dermatitis (HP:0000976)3.40935819
8Obstructive sleep apnea (HP:0002870)3.37457617
9Broad face (HP:0000283)3.17714215
10Atonic seizures (HP:0010819)3.12732060
11Degeneration of the lateral corticospinal tracts (HP:0002314)3.09958392
12Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.09958392
13Focal seizures (HP:0007359)3.09691346
14Agammaglobulinemia (HP:0004432)3.04268969
15Dysmetria (HP:0001310)2.99939775
16Scanning speech (HP:0002168)2.99068279
17Myokymia (HP:0002411)2.96378625
18Panhypogammaglobulinemia (HP:0003139)2.93474063
19Peripheral hypomyelination (HP:0007182)2.92436499
20Hyperacusis (HP:0010780)2.83318567
21Papilledema (HP:0001085)2.79012028
22Verrucae (HP:0200043)2.78188425
23Papilloma (HP:0012740)2.78188425
24Recurrent bacterial skin infections (HP:0005406)2.77853775
25Sparse lateral eyebrow (HP:0005338)2.77309352
26Deep palmar crease (HP:0006191)2.73830454
27Increased IgE level (HP:0003212)2.70768466
28Thin bony cortex (HP:0002753)2.68952084
29Cellulitis (HP:0100658)2.68822778
30Recurrent abscess formation (HP:0002722)2.67922443
31Abnormal delayed hypersensitivity skin test (HP:0002963)2.66689480
32T lymphocytopenia (HP:0005403)2.65728171
33Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.63204818
34Abnormality of macrophages (HP:0004311)2.62915372
35Ankle clonus (HP:0011448)2.62803321
36Hypercortisolism (HP:0001578)2.60282509
37Chronic sinusitis (HP:0011109)2.56506233
38Germ cell neoplasia (HP:0100728)2.56108224
39Recurrent viral infections (HP:0004429)2.54600349
40Absence seizures (HP:0002121)2.53972551
41Macroorchidism (HP:0000053)2.50644388
42Inflammation of the large intestine (HP:0002037)2.50513309
43Abnormality of T cell number (HP:0011839)2.50182897
44Spastic gait (HP:0002064)2.50168313
45Asymmetry of the thorax (HP:0001555)2.49176265
46Thyroiditis (HP:0100646)2.49136977
47Truncal ataxia (HP:0002078)2.49043750
48B lymphocytopenia (HP:0010976)2.49038060
49Abnormality of B cell number (HP:0010975)2.49038060
50Urinary urgency (HP:0000012)2.48626452
51Intention tremor (HP:0002080)2.44301404
52Abnormality of the corticospinal tract (HP:0002492)2.43560585
53Gastrointestinal inflammation (HP:0004386)2.43455188
54Thickened helices (HP:0000391)2.43015575
55Ulnar bowing (HP:0003031)2.42822593
56Hyperparathyroidism (HP:0000843)2.41680083
57Long palpebral fissure (HP:0000637)2.39140676
58Diplopia (HP:0000651)2.37816322
59Abnormality of binocular vision (HP:0011514)2.37816322
60Onion bulb formation (HP:0003383)2.37151082
61Nasal polyposis (HP:0100582)2.35977521
62Colitis (HP:0002583)2.34776950
63Abnormality of the distal phalanx of the thumb (HP:0009617)2.34748157
64Dialeptic seizures (HP:0011146)2.34522647
65IgM deficiency (HP:0002850)2.30301532
66Recurrent bronchitis (HP:0002837)2.29713498
67Slow saccadic eye movements (HP:0000514)2.28849000
68Subacute progressive viral hepatitis (HP:0006572)2.27251338
69Meningitis (HP:0001287)2.27213068
70Septate vagina (HP:0001153)2.26437444
71Mutism (HP:0002300)2.23679057
72Elevated erythrocyte sedimentation rate (HP:0003565)2.23003049
73Deep venous thrombosis (HP:0002625)2.22198168
74Hemorrhage of the eye (HP:0011885)2.21540605
75Hemiplegia (HP:0002301)2.21072773
76Progressive inability to walk (HP:0002505)2.18010051
77Dysostosis multiplex (HP:0000943)2.17304763
78Micronodular cirrhosis (HP:0001413)2.15974630
79Segmental peripheral demyelination/remyelination (HP:0003481)2.15165551
80Mediastinal lymphadenopathy (HP:0100721)2.15042304
81Stereotypic behavior (HP:0000733)2.12852786
82Cerebral aneurysm (HP:0004944)2.12486648
83Abnormal social behavior (HP:0012433)2.12355125
84Impaired social interactions (HP:0000735)2.12355125
85Clumsiness (HP:0002312)2.10951053
86Poor eye contact (HP:0000817)2.10519879
87Myositis (HP:0100614)2.10080266
88Broad-based gait (HP:0002136)2.09688051
89J-shaped sella turcica (HP:0002680)2.09491877
90Hypochromic anemia (HP:0001931)2.09326588
91Drooling (HP:0002307)2.08801511
92Excessive salivation (HP:0003781)2.08801511
93Chronic obstructive pulmonary disease (HP:0006510)2.07705569
94Obstructive lung disease (HP:0006536)2.07705569
95Recurrent fungal infections (HP:0002841)2.05504943
96Abnormality of oral frenula (HP:0000190)2.05459904
97Viral hepatitis (HP:0006562)2.05158978
98Orchitis (HP:0100796)2.04071539
99Abnormality of the thoracic spine (HP:0100711)2.03161250
100Termporal pattern (HP:0011008)2.02706057
101Insidious onset (HP:0003587)2.02706057
102Achilles tendon contracture (HP:0001771)2.01975736
103Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.01811046
104Megalencephaly (HP:0001355)1.99672070
105Abnormality of saccadic eye movements (HP:0000570)1.96795094
106Growth hormone excess (HP:0000845)1.95929153
107Testicular neoplasm (HP:0010788)1.94884263
108Loss of speech (HP:0002371)1.94272683
109Easy fatigability (HP:0003388)1.94043379
110Spontaneous hematomas (HP:0007420)1.92664925
111Febrile seizures (HP:0002373)1.91854048
112Depression (HP:0000716)1.91704849
113Torticollis (HP:0000473)1.91015380
114Neuronal loss in central nervous system (HP:0002529)1.90840488
115Polygenic inheritance (HP:0010982)1.90377937
116Broad distal phalanx of finger (HP:0009836)1.89843367
117Gastrointestinal infarctions (HP:0005244)1.88986634
118Generalized tonic-clonic seizures (HP:0002069)1.88952794
119Abnormality of the phalanges of the hallux (HP:0010057)1.88486152
120Disproportionate tall stature (HP:0001519)1.87781271
121Anxiety (HP:0000739)1.87574074
122Pustule (HP:0200039)1.87232514
123Rapidly progressive (HP:0003678)1.86373344
124Abnormality of the nasal mucosa (HP:0000433)1.86347874
125Insomnia (HP:0100785)1.85637905
126Epileptic encephalopathy (HP:0200134)1.84627716
127Hyperventilation (HP:0002883)1.84448603
128Exotropia (HP:0000577)1.84086563
129Dislocated radial head (HP:0003083)1.83912037
130Interstitial pulmonary disease (HP:0006530)1.82747141
131Abnormality of the Achilles tendon (HP:0005109)1.82538358
132Abnormality of salivation (HP:0100755)1.82523686
133Amyloidosis (HP:0011034)1.80693777
134Genetic anticipation (HP:0003743)1.80624132
135Impaired smooth pursuit (HP:0007772)1.80449989
136Stridor (HP:0010307)1.79053574
137Abnormality of the radial head (HP:0003995)1.78094051
138Stomatitis (HP:0010280)1.77435529
139Widely spaced teeth (HP:0000687)1.77175550
140Increased serum ferritin (HP:0003281)1.75803011
141Parakeratosis (HP:0001036)1.75714277
142Abnormality of the fingertips (HP:0001211)1.75324576
143Deformed sella turcica (HP:0002681)1.75150263
144Hypoparathyroidism (HP:0000829)1.75123605
145Optic neuritis (HP:0100653)1.75016953
146Retrobulbar optic neuritis (HP:0100654)1.75016953
147Seborrheic dermatitis (HP:0001051)1.74849281
148Increased cerebral lipofuscin (HP:0011813)1.74789551
149Flat acetabular roof (HP:0003180)1.74502140
150Ankyloglossia (HP:0010296)1.74018740
151Progressive cerebellar ataxia (HP:0002073)1.73016865
152Recurrent skin infections (HP:0001581)1.72886709
153Supernumerary nipples (HP:0002558)1.72269219
154Eosinophilia (HP:0001880)1.72177479
155Aplasia involving bones of the upper limbs (HP:0009823)1.71813256
156Aplasia of the phalanges of the hand (HP:0009802)1.71813256
157Aplasia involving bones of the extremities (HP:0009825)1.71813256
158Abnormality of the distal phalanges of the toes (HP:0010182)1.71704737
159Hyperthyroidism (HP:0000836)1.71423024
160Sensory axonal neuropathy (HP:0003390)1.71188852
161Reticulocytosis (HP:0001923)1.70879273
162Truncus arteriosus (HP:0001660)1.70811905
163Diminished motivation (HP:0000745)1.70763307
164Dysdiadochokinesis (HP:0002075)1.70613826
165Gingivitis (HP:0000230)1.70346213
166Thoracic kyphosis (HP:0002942)1.69422697
167Abnormality of the columella (HP:0009929)1.68806879
168Bowel incontinence (HP:0002607)1.67319337
169Patellar dislocation (HP:0002999)1.64993114
170Hypertriglyceridemia (HP:0002155)1.63856342
171Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.63307291
172Abnormality of the aortic arch (HP:0012303)1.62737980
173Gastrointestinal stroma tumor (HP:0100723)1.61941763
174Heterotopia (HP:0002282)1.60543918
175Emphysema (HP:0002097)1.60523326
176Abnormality of the parietal bone (HP:0002696)1.60046810
177Vertebral compression fractures (HP:0002953)1.59428857
178Purpura (HP:0000979)1.59334957
179Vasculitis (HP:0002633)1.58623936
180Urinary glycosaminoglycan excretion (HP:0003541)1.58231890
181Mucopolysacchariduria (HP:0008155)1.58231890
182Abnormality of glycosphingolipid metabolism (HP:0004343)1.58096745

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.96187214
2CDK123.04892152
3MAP4K12.87874581
4SIK22.65580415
5SMG12.58203518
6EPHB12.57341731
7FES2.44125577
8EEF2K2.43352088
9IRAK32.27402090
10IRAK42.14200432
11EPHA41.97033338
12STK391.95538657
13MAP2K31.91851890
14MAP3K131.83857412
15MAP3K101.83149324
16GRK61.81993144
17TAOK11.78819626
18MAPK151.69820557
19MARK21.69663731
20FGFR21.65575105
21NTRK31.58568934
22RIPK41.58527759
23UHMK11.50667480
24TAOK21.47866830
25RIPK11.45301012
26MAP3K91.42046197
27NTRK21.39810684
28TNIK1.38437076
29MAP3K31.38306041
30CDK191.37847592
31CAMK1G1.37560417
32ITK1.35917139
33NME21.34303756
34SIK31.27019407
35PRKD31.24234225
36PRKCH1.24126624
37EPHA21.23750366
38NTRK11.23686951
39PKN11.21553868
40CLK11.20124811
41TNK21.17796596
42MAP3K111.17743495
43MAP3K71.17049490
44PRKD21.16183511
45SYK1.14707009
46PRKCQ1.11597626
47STK111.10491624
48IKBKE1.10189979
49PAK61.09643408
50MAPKAPK51.09250023
51KSR21.08824299
52HCK1.08734078
53* HIPK21.02734869
54PNCK1.01260119
55SIK10.98769055
56CAMK2B0.98489109
57MAP2K20.98430849
58CDK50.98201838
59MTOR0.98004484
60ERN10.96784576
61ZAP700.96322630
62TXK0.94479801
63BTK0.93138492
64OXSR10.92317218
65FGFR30.92056890
66PAK30.91463595
67RPS6KB20.90859658
68CHUK0.88223793
69CAMK1D0.86742734
70CAMK10.86733698
71JAK10.86732638
72RET0.85391082
73RPS6KL10.83562672
74RPS6KC10.83562672
75TAOK30.83513562
76FGR0.83472062
77BRAF0.82974334
78PTK60.82704274
79MARK30.82414891
80ALK0.81566890
81TRIB30.80912785
82AKT30.80263424
83LCK0.79386909
84CAMKK10.77067412
85FGFR40.76153621
86IKBKB0.75272920
87NLK0.75112520
88TYRO30.73521085
89MINK10.72778833
90ROCK20.71980782
91CSNK1A1L0.71767888
92CDC42BPA0.71756334
93DYRK1B0.70931290
94WNK10.70886079
95MAP3K10.70366884
96LRRK20.69451375
97TBK10.68650349
98MAP3K140.68381809
99IRAK10.67530750
100MARK10.66571609
101RPS6KA60.66547835
102CDK40.66273834
103MAPK110.66258267
104CSNK1G20.65451261
105ARAF0.65450152
106SGK2230.65283783
107SGK4940.65283783
108PDK10.64400857
109DMPK0.64289633
110PRKD10.63949645
111MAPK40.63695759
112BLK0.63669753
113RAF10.63439499
114MAP3K20.61509963
115FYN0.61496475
116TYK20.61420550
117SGK30.60876018
118TEC0.58399046
119PKN20.58348933
120DAPK20.57878800
121ICK0.57720884
122MAP3K40.57598515
123RPS6KA20.57566230
124MAPK130.57303522
125CDK70.56594208
126CSK0.56037458
127BRD40.55008886
128CAMK2A0.53558793
129CAMK2D0.52523886
130MAPK120.52430081
131CSF1R0.51651017
132PDPK10.51477019
133JAK20.51450111
134IRAK20.51405270
135CAMK2G0.51255410
136RPS6KA10.50455381
137WNK40.50250231
138STK100.49189622
139CDK60.48844249
140TESK20.48451475
141PIM20.48122992
142ILK0.47302630
143MAPKAPK30.43494336
144SCYL20.43493195
145JAK30.43359362
146MAP3K60.42030639
147MAPKAPK20.40883374
148STK380.37325324
149MAP3K80.36935501
150MAPK70.36462996
151LATS20.35587658
152PIM10.35378908
153CDK90.34261693
154MAPK80.33126059

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047402.38283879
2Other glycan degradation_Homo sapiens_hsa005112.02285201
3Morphine addiction_Homo sapiens_hsa050322.01144960
4Primary immunodeficiency_Homo sapiens_hsa053402.00258391
5B cell receptor signaling pathway_Homo sapiens_hsa046621.86771092
6Long-term potentiation_Homo sapiens_hsa047201.86635231
7Notch signaling pathway_Homo sapiens_hsa043301.84661725
8Glutamatergic synapse_Homo sapiens_hsa047241.84454950
9GABAergic synapse_Homo sapiens_hsa047271.83855357
10Circadian entrainment_Homo sapiens_hsa047131.83537955
11Toll-like receptor signaling pathway_Homo sapiens_hsa046201.83252421
12Salivary secretion_Homo sapiens_hsa049701.79196488
13Aldosterone synthesis and secretion_Homo sapiens_hsa049251.79004247
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74456601
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.72496288
16T cell receptor signaling pathway_Homo sapiens_hsa046601.70501070
17Renin secretion_Homo sapiens_hsa049241.67320254
18Amphetamine addiction_Homo sapiens_hsa050311.65765677
19Gastric acid secretion_Homo sapiens_hsa049711.65433872
20Bladder cancer_Homo sapiens_hsa052191.64664493
21Nicotine addiction_Homo sapiens_hsa050331.63244212
22Dopaminergic synapse_Homo sapiens_hsa047281.62088463
23Cocaine addiction_Homo sapiens_hsa050301.60127055
24Cholinergic synapse_Homo sapiens_hsa047251.54316142
25mTOR signaling pathway_Homo sapiens_hsa041501.45442711
26TNF signaling pathway_Homo sapiens_hsa046681.42464453
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.41712289
28Long-term depression_Homo sapiens_hsa047301.37526359
29Influenza A_Homo sapiens_hsa051641.36909640
30Prion diseases_Homo sapiens_hsa050201.34529576
31Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31553688
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31548633
33Serotonergic synapse_Homo sapiens_hsa047261.29018307
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.28162043
35Osteoclast differentiation_Homo sapiens_hsa043801.27285771
36Estrogen signaling pathway_Homo sapiens_hsa049151.26655614
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25310321
38Measles_Homo sapiens_hsa051621.24122709
39ErbB signaling pathway_Homo sapiens_hsa040121.22593857
40Tuberculosis_Homo sapiens_hsa051521.19963892
41Oxytocin signaling pathway_Homo sapiens_hsa049211.18281846
42cAMP signaling pathway_Homo sapiens_hsa040241.18202537
43Taste transduction_Homo sapiens_hsa047421.17219110
44Chemokine signaling pathway_Homo sapiens_hsa040621.16932581
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16505369
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14219099
47Thyroid cancer_Homo sapiens_hsa052161.13663356
48Axon guidance_Homo sapiens_hsa043601.13282929
49Dorso-ventral axis formation_Homo sapiens_hsa043201.12055676
50Thyroid hormone signaling pathway_Homo sapiens_hsa049191.11790545
51Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.11695653
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.11074444
53GnRH signaling pathway_Homo sapiens_hsa049121.10707423
54Central carbon metabolism in cancer_Homo sapiens_hsa052301.10012066
55Insulin secretion_Homo sapiens_hsa049111.09680332
56Longevity regulating pathway - mammal_Homo sapiens_hsa042111.09025623
57Insulin signaling pathway_Homo sapiens_hsa049101.08718416
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08657650
59Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07830604
60NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07514921
61Glioma_Homo sapiens_hsa052141.06950111
62VEGF signaling pathway_Homo sapiens_hsa043701.06562401
63Renal cell carcinoma_Homo sapiens_hsa052111.06475925
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04575583
65Apoptosis_Homo sapiens_hsa042101.04072316
66FoxO signaling pathway_Homo sapiens_hsa040681.02356844
67Sphingolipid signaling pathway_Homo sapiens_hsa040711.01863499
68Herpes simplex infection_Homo sapiens_hsa051680.99987125
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.98455146
70MAPK signaling pathway_Homo sapiens_hsa040100.98131942
71Calcium signaling pathway_Homo sapiens_hsa040200.98073662
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.96634129
73Phospholipase D signaling pathway_Homo sapiens_hsa040720.96631375
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95526601
75Platelet activation_Homo sapiens_hsa046110.94255955
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93390695
77Acute myeloid leukemia_Homo sapiens_hsa052210.92517347
78Insulin resistance_Homo sapiens_hsa049310.92459320
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.92447530
80Synaptic vesicle cycle_Homo sapiens_hsa047210.92223480
81Non-small cell lung cancer_Homo sapiens_hsa052230.91739059
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90847420
83Viral carcinogenesis_Homo sapiens_hsa052030.89591153
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.89388770
85Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88649521
86Choline metabolism in cancer_Homo sapiens_hsa052310.86961716
87HTLV-I infection_Homo sapiens_hsa051660.85957897
88Chronic myeloid leukemia_Homo sapiens_hsa052200.83991160
89Type II diabetes mellitus_Homo sapiens_hsa049300.83589351
90Gap junction_Homo sapiens_hsa045400.83324937
91HIF-1 signaling pathway_Homo sapiens_hsa040660.82834186
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80098460
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79967078
94Endocytosis_Homo sapiens_hsa041440.79720573
95AMPK signaling pathway_Homo sapiens_hsa041520.79334325
96Leukocyte transendothelial migration_Homo sapiens_hsa046700.79048391
97MicroRNAs in cancer_Homo sapiens_hsa052060.78419414
98Pancreatic secretion_Homo sapiens_hsa049720.76451091
99Melanogenesis_Homo sapiens_hsa049160.75195717
100Small cell lung cancer_Homo sapiens_hsa052220.75155153
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75045045
102Pancreatic cancer_Homo sapiens_hsa052120.74707695
103Ras signaling pathway_Homo sapiens_hsa040140.74013446
104Epstein-Barr virus infection_Homo sapiens_hsa051690.73185346
105Malaria_Homo sapiens_hsa051440.72322713
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72117769
107Thyroid hormone synthesis_Homo sapiens_hsa049180.71940621
108Prolactin signaling pathway_Homo sapiens_hsa049170.71900013
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69875820
110Legionellosis_Homo sapiens_hsa051340.68417429
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68240035
112AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64927345
113Lysosome_Homo sapiens_hsa041420.64706518
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64270895
115Shigellosis_Homo sapiens_hsa051310.63507672
116Salmonella infection_Homo sapiens_hsa051320.62947567
117Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60507521
118Amoebiasis_Homo sapiens_hsa051460.60240696
119Staphylococcus aureus infection_Homo sapiens_hsa051500.59404763
120Inositol phosphate metabolism_Homo sapiens_hsa005620.59397675
121Nitrogen metabolism_Homo sapiens_hsa009100.59167036
122Rap1 signaling pathway_Homo sapiens_hsa040150.58183130
123Sulfur relay system_Homo sapiens_hsa041220.56380843
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.55872361
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54958053
126Allograft rejection_Homo sapiens_hsa053300.53801556
127Viral myocarditis_Homo sapiens_hsa054160.53714930
128Fructose and mannose metabolism_Homo sapiens_hsa000510.53519650
129Intestinal immune network for IgA production_Homo sapiens_hsa046720.53112734
130Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52723211
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.47701943
132Proteoglycans in cancer_Homo sapiens_hsa052050.46829820
133Graft-versus-host disease_Homo sapiens_hsa053320.45861445
134Hepatitis B_Homo sapiens_hsa051610.45727700
135Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44778901
136Phototransduction_Homo sapiens_hsa047440.42606660
137Colorectal cancer_Homo sapiens_hsa052100.42041615
138Jak-STAT signaling pathway_Homo sapiens_hsa046300.41067104
139African trypanosomiasis_Homo sapiens_hsa051430.39398910
140Hepatitis C_Homo sapiens_hsa051600.39362544
141Toxoplasmosis_Homo sapiens_hsa051450.39046080
142Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.37590994
143Prostate cancer_Homo sapiens_hsa052150.37253101
144Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37142582
145Pertussis_Homo sapiens_hsa051330.36622838
146Adipocytokine signaling pathway_Homo sapiens_hsa049200.36273617
147Endometrial cancer_Homo sapiens_hsa052130.36177705
148Leishmaniasis_Homo sapiens_hsa051400.35910194
149NF-kappa B signaling pathway_Homo sapiens_hsa040640.35156652

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