CBX3P2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histamine transport (GO:0051608)6.55732612
2organic cation transport (GO:0015695)5.19431216
3meiotic chromosome segregation (GO:0045132)5.01099201
4resolution of meiotic recombination intermediates (GO:0000712)4.47516059
5neurotransmitter biosynthetic process (GO:0042136)4.43138282
6positive regulation of meiosis (GO:0045836)4.35846474
7exogenous drug catabolic process (GO:0042738)4.34328227
8neurotransmitter metabolic process (GO:0042133)4.30536156
9negative regulation of telomere maintenance (GO:0032205)4.28093541
10positive regulation of mast cell activation (GO:0033005)4.27586443
11regulation of activation of Janus kinase activity (GO:0010533)4.21961118
12negative regulation of mast cell activation (GO:0033004)4.20422913
13behavioral response to nicotine (GO:0035095)4.18116363
14drug transmembrane transport (GO:0006855)4.16631312
15positive regulation of meiotic cell cycle (GO:0051446)4.00480971
16azole transport (GO:0045117)3.92252550
17detection of chemical stimulus involved in sensory perception of smell (GO:0050911)3.75831656
18quaternary ammonium group transport (GO:0015697)3.58477131
19regulation of T cell tolerance induction (GO:0002664)3.58453625
20regulation of memory T cell differentiation (GO:0043380)3.57073239
21tooth mineralization (GO:0034505)3.56825438
22regulation of mast cell activation (GO:0033003)3.52447464
23negative regulation of calcium ion transport into cytosol (GO:0010523)3.51101210
24positive regulation of defense response to virus by host (GO:0002230)3.45899034
25rRNA methylation (GO:0031167)3.43359030
26reciprocal meiotic recombination (GO:0007131)3.42725545
27reciprocal DNA recombination (GO:0035825)3.42725545
28centriole replication (GO:0007099)3.40871603
29rRNA catabolic process (GO:0016075)3.37181309
30cilium or flagellum-dependent cell motility (GO:0001539)3.34490142
31regulation of T cell cytokine production (GO:0002724)3.30291495
32regulation of B cell receptor signaling pathway (GO:0050855)3.23268554
33secretory granule organization (GO:0033363)3.22237848
34regulation of tolerance induction (GO:0002643)3.21284779
35positive regulation of histone deacetylation (GO:0031065)3.20701259
36drug catabolic process (GO:0042737)3.19706655
37regulation of MHC class II biosynthetic process (GO:0045346)3.19480563
38DNA deamination (GO:0045006)3.15875871
39regulation of chronic inflammatory response (GO:0002676)3.14731346
40regulation of hexokinase activity (GO:1903299)3.13173002
41regulation of glucokinase activity (GO:0033131)3.13173002
42fatty acid elongation (GO:0030497)3.10363068
43synaptonemal complex assembly (GO:0007130)3.10285619
44sequestering of actin monomers (GO:0042989)3.08616499
45neutrophil activation (GO:0042119)3.02532541
46regulation of meiosis I (GO:0060631)3.01548063
47RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.01449498
48regulation of defense response to virus by host (GO:0050691)2.99750166
49lysosome localization (GO:0032418)2.98139801
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.96314784
51metallo-sulfur cluster assembly (GO:0031163)2.94608042
52iron-sulfur cluster assembly (GO:0016226)2.94608042
53regulation of mesenchymal cell apoptotic process (GO:2001053)2.92626834
54positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.92294900
55drug transport (GO:0015893)2.92205846
56activated T cell proliferation (GO:0050798)2.91492528
57positive regulation of mast cell activation involved in immune response (GO:0033008)2.91390390
58positive regulation of mast cell degranulation (GO:0043306)2.91390390
59positive regulation of toll-like receptor signaling pathway (GO:0034123)2.88006154
60rRNA modification (GO:0000154)2.86790702
61cellular response to exogenous dsRNA (GO:0071360)2.85407442
62regulation of telomere maintenance (GO:0032204)2.85016679
63cellular extravasation (GO:0045123)2.82892622
64regulation of growth of symbiont in host (GO:0044126)2.80638834
65negative regulation of growth of symbiont in host (GO:0044130)2.80638834
66negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.80638834
67modulation of growth of symbiont involved in interaction with host (GO:0044144)2.80638834
68synaptonemal complex organization (GO:0070193)2.79607051
69regulation of interleukin-8 secretion (GO:2000482)2.77507250
70histone H3-K36 demethylation (GO:0070544)2.72027384
71GPI anchor metabolic process (GO:0006505)2.70071961
72cytidine metabolic process (GO:0046087)2.68698302
73cytidine catabolic process (GO:0006216)2.68698302
74cytidine deamination (GO:0009972)2.68698302
75preassembly of GPI anchor in ER membrane (GO:0016254)2.68416971
76cornea development in camera-type eye (GO:0061303)2.67439438
77positive regulation of T cell mediated cytotoxicity (GO:0001916)2.67405637
78regulation of interleukin-6 biosynthetic process (GO:0045408)2.67094783
79regulation of T cell mediated immunity (GO:0002709)2.65248375
80DNA dealkylation (GO:0035510)2.64867725
81imidazole-containing compound metabolic process (GO:0052803)2.64550139
82regulation of T cell chemotaxis (GO:0010819)2.63010717
83positive regulation of T cell chemotaxis (GO:0010820)2.63010717
84piRNA metabolic process (GO:0034587)2.60746395
85chromosome organization involved in meiosis (GO:0070192)2.59685114
86response to pheromone (GO:0019236)2.56890209
87detection of chemical stimulus involved in sensory perception (GO:0050907)2.56589053
88bone trabecula formation (GO:0060346)2.56378586
89base-excision repair, AP site formation (GO:0006285)2.55657386
90positive regulation of protein deacetylation (GO:0090312)2.54973552
91purinergic nucleotide receptor signaling pathway (GO:0035590)2.54648205
92L-fucose catabolic process (GO:0042355)2.54344622
93fucose catabolic process (GO:0019317)2.54344622
94L-fucose metabolic process (GO:0042354)2.54344622
95positive regulation of hair follicle development (GO:0051798)2.53625229
96positive regulation of hair cycle (GO:0042635)2.53625229
97natural killer cell activation involved in immune response (GO:0002323)2.53405731
98protein polyglutamylation (GO:0018095)2.51342363
99centriole assembly (GO:0098534)2.50671410
100regulation of MHC class I biosynthetic process (GO:0045343)2.49747228

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.45793476
2ZNF274_21170338_ChIP-Seq_K562_Hela4.43443821
3IGF1R_20145208_ChIP-Seq_DFB_Human3.56212329
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.39195526
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.63899018
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.52718121
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.37366528
8IRF1_19129219_ChIP-ChIP_H3396_Human2.25276173
9POU3F2_20337985_ChIP-ChIP_501MEL_Human1.96907843
10ER_23166858_ChIP-Seq_MCF-7_Human1.96080499
11EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.95685351
12PCGF2_27294783_Chip-Seq_NPCs_Mouse1.94563526
13CTBP2_25329375_ChIP-Seq_LNCAP_Human1.90821835
14EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.90172464
15ZFP57_27257070_Chip-Seq_ESCs_Mouse1.89124909
16NOTCH1_21737748_ChIP-Seq_TLL_Human1.85334672
17MYB_26560356_Chip-Seq_TH2_Human1.85290076
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82489142
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79134099
20NANOG_20526341_ChIP-Seq_ESCs_Human1.75499356
21EWS_26573619_Chip-Seq_HEK293_Human1.74142399
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.70216484
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.70132814
24VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.65255841
25CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64991235
26TP53_22573176_ChIP-Seq_HFKS_Human1.62971344
27ETV2_25802403_ChIP-Seq_MESCs_Mouse1.61341224
28GBX2_23144817_ChIP-Seq_PC3_Human1.59323176
29VDR_23849224_ChIP-Seq_CD4+_Human1.59157848
30GATA3_26560356_Chip-Seq_TH2_Human1.58234319
31NANOG_19829295_ChIP-Seq_ESCs_Human1.54545689
32SOX2_19829295_ChIP-Seq_ESCs_Human1.54545689
33MYC_18940864_ChIP-ChIP_HL60_Human1.46729627
34AUTS2_25519132_ChIP-Seq_293T-REX_Human1.43916645
35FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.43437687
36FUS_26573619_Chip-Seq_HEK293_Human1.41765741
37GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.37401775
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.36944556
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36115108
40FOXA1_21572438_ChIP-Seq_LNCaP_Human1.34325270
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.34242508
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.34050979
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33882789
44AR_20517297_ChIP-Seq_VCAP_Human1.32886394
45PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.32824530
46RAC3_21632823_ChIP-Seq_H3396_Human1.32324870
47VDR_22108803_ChIP-Seq_LS180_Human1.31369351
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30260672
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29208256
50FOXP3_21729870_ChIP-Seq_TREG_Human1.27789904
51LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.24735483
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23259788
53FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23210827
54FOXA1_25329375_ChIP-Seq_VCAP_Human1.23210827
55SALL1_21062744_ChIP-ChIP_HESCs_Human1.22494649
56SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.21642091
57P300_19829295_ChIP-Seq_ESCs_Human1.20835114
58CIITA_25753668_ChIP-Seq_RAJI_Human1.20818701
59GATA3_26560356_Chip-Seq_TH1_Human1.20625926
60UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20148226
61ERA_21632823_ChIP-Seq_H3396_Human1.19334574
62CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.19199572
63TCF4_23295773_ChIP-Seq_U87_Human1.17821753
64SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16442560
65NCOR_22424771_ChIP-Seq_293T_Human1.16004008
66STAT3_23295773_ChIP-Seq_U87_Human1.15573676
67GATA3_27048872_Chip-Seq_THYMUS_Human1.14597525
68P53_21459846_ChIP-Seq_SAOS-2_Human1.14212131
69TAF2_19829295_ChIP-Seq_ESCs_Human1.12270445
70GABP_17652178_ChIP-ChIP_JURKAT_Human1.10687724
71EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09790760
72GATA3_21878914_ChIP-Seq_MCF-7_Human1.09762672
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09368014
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07230614
75HOXB7_26014856_ChIP-Seq_BT474_Human1.06279542
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.05703051
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.05589972
78GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.03973510
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.03569602
80E2F1_20622854_ChIP-Seq_HELA_Human1.03541723
81OCT4_20526341_ChIP-Seq_ESCs_Human1.03293295
82RUNX_20019798_ChIP-Seq_JUKART_Human1.03052583
83MYB_26560356_Chip-Seq_TH1_Human1.02623944
84MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02604006
85FOXH1_21741376_ChIP-Seq_ESCs_Human1.02250705
86PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02189668
87TAF15_26573619_Chip-Seq_HEK293_Human1.02142473
88CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01639440
89SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.99681280
90IRF8_21731497_ChIP-ChIP_J774_Mouse0.99605289
91FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99226616
92OCT1_27270436_Chip-Seq_PROSTATE_Human0.98851404
93MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98570951
94E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.98495054
95CBP_20019798_ChIP-Seq_JUKART_Human0.98015517
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98015517
97P300_27268052_Chip-Seq_Bcells_Human0.97593148
98GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.97400989
99FOXH1_21741376_ChIP-Seq_EPCs_Human0.96384862
100RUNX2_22187159_ChIP-Seq_PCA_Human0.95610855

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.00829066
2MP0003646_muscle_fatigue2.95724154
3MP0008877_abnormal_DNA_methylation2.90205158
4MP0000372_irregular_coat_pigmentation2.89499348
5MP0001835_abnormal_antigen_presentation2.68406254
6MP0005671_abnormal_response_to2.46814445
7MP0002102_abnormal_ear_morphology2.44864231
8MP0005075_abnormal_melanosome_morpholog2.43555120
9MP0005645_abnormal_hypothalamus_physiol2.35436275
10MP0001873_stomach_inflammation2.24055267
11MP0008872_abnormal_physiological_respon2.19493108
12MP0008057_abnormal_DNA_replication2.17770579
13MP0005387_immune_system_phenotype2.14175318
14MP0001790_abnormal_immune_system2.14175318
15MP0001529_abnormal_vocalization2.08242776
16MP0003787_abnormal_imprinting2.04214197
17MP0004043_abnormal_pH_regulation2.03959762
18MP0002160_abnormal_reproductive_system2.02636247
19MP0001919_abnormal_reproductive_system2.00895499
20MP0001986_abnormal_taste_sensitivity1.95600559
21MP0001800_abnormal_humoral_immune1.88538081
22MP0008995_early_reproductive_senescence1.82255722
23MP0005389_reproductive_system_phenotype1.81133543
24MP0005410_abnormal_fertilization1.78739390
25MP0002735_abnormal_chemical_nociception1.72935146
26MP0002148_abnormal_hypersensitivity_rea1.69864355
27MP0005085_abnormal_gallbladder_physiolo1.68093542
28MP0008058_abnormal_DNA_repair1.66595408
29MP0003195_calcinosis1.56898128
30MP0000569_abnormal_digit_pigmentation1.54229823
31MP0002723_abnormal_immune_serum1.52999497
32MP0004142_abnormal_muscle_tone1.48895607
33MP0005167_abnormal_blood-brain_barrier1.48634691
34MP0002420_abnormal_adaptive_immunity1.46635797
35MP0001819_abnormal_immune_cell1.45282181
36MP0002452_abnormal_antigen_presenting1.42848952
37MP0002822_catalepsy1.38918398
38MP0002733_abnormal_thermal_nociception1.37388362
39MP0003763_abnormal_thymus_physiology1.29859839
40MP0002837_dystrophic_cardiac_calcinosis1.26996801
41MP0009785_altered_susceptibility_to1.26975674
42MP0005551_abnormal_eye_electrophysiolog1.26355700
43MP0002419_abnormal_innate_immunity1.24960191
44MP0004381_abnormal_hair_follicle1.23549550
45MP0005000_abnormal_immune_tolerance1.23141251
46MP0004742_abnormal_vestibular_system1.23058212
47MP0010329_abnormal_lipoprotein_level1.20591495
48MP0000015_abnormal_ear_pigmentation1.20140891
49MP0006082_CNS_inflammation1.18542687
50MP0009764_decreased_sensitivity_to1.17417684
51MP0005025_abnormal_response_to1.16837465
52MP0000716_abnormal_immune_system1.13269443
53MP0003786_premature_aging1.12051622
54MP0008961_abnormal_basal_metabolism1.11675845
55MP0001764_abnormal_homeostasis1.08805410
56MP0005647_abnormal_sex_gland1.08318548
57MP0006276_abnormal_autonomic_nervous1.05912933
58MP0001501_abnormal_sleep_pattern1.05281623
59MP0000465_gastrointestinal_hemorrhage1.05052394
60MP0008875_abnormal_xenobiotic_pharmacok1.04099386
61MP0002398_abnormal_bone_marrow1.04065019
62MP0003698_abnormal_male_reproductive1.02278725
63MP0005365_abnormal_bile_salt1.01457336
64MP0006036_abnormal_mitochondrial_physio1.01393688
65MP0003436_decreased_susceptibility_to1.01380344
66MP0005083_abnormal_biliary_tract1.00467793
67MP0000685_abnormal_immune_system0.99908978
68MP0003252_abnormal_bile_duct0.99060965
69MP0005310_abnormal_salivary_gland0.98655003
70MP0005174_abnormal_tail_pigmentation0.98109201
71MP0002095_abnormal_skin_pigmentation0.97805556
72MP0001970_abnormal_pain_threshold0.96670356
73MP0005084_abnormal_gallbladder_morpholo0.96357800
74MP0005266_abnormal_metabolism0.95446049
75MP0005253_abnormal_eye_physiology0.95027265
76MP0000427_abnormal_hair_cycle0.94007747
77MP0002210_abnormal_sex_determination0.93926744
78MP0005171_absent_coat_pigmentation0.93364122
79MP0001929_abnormal_gametogenesis0.93028881
80MP0002876_abnormal_thyroid_physiology0.91879153
81MP0003136_yellow_coat_color0.91009068
82MP0004130_abnormal_muscle_cell0.90772848
83MP0001346_abnormal_lacrimal_gland0.89878196
84MP0000371_diluted_coat_color0.89786570
85MP0002429_abnormal_blood_cell0.86789341
86MP0000689_abnormal_spleen_morphology0.86328090
87MP0009745_abnormal_behavioral_response0.86003217
88MP0002163_abnormal_gland_morphology0.85897436
89MP0004484_altered_response_of0.82816694
90MP0010386_abnormal_urinary_bladder0.79506116
91MP0003172_abnormal_lysosome_physiology0.79469564
92MP0009115_abnormal_fat_cell0.78446502
93MP0006054_spinal_hemorrhage0.77915941
94MP0001845_abnormal_inflammatory_respons0.75944136
95MP0001145_abnormal_male_reproductive0.75022506
96MP0002405_respiratory_system_inflammati0.74111942
97MP0002272_abnormal_nervous_system0.74010370
98MP0005334_abnormal_fat_pad0.73675475
99MP0002722_abnormal_immune_system0.72094496
100MP0001968_abnormal_touch/_nociception0.71708777

Predicted human phenotypes

RankGene SetZ-score
1Unilateral renal agenesis (HP:0000122)5.10652893
2Progressive inability to walk (HP:0002505)4.57452610
3Hypoplasia of the fovea (HP:0007750)4.41933403
4Aplasia/Hypoplasia of the fovea (HP:0008060)4.41933403
5Conjugated hyperbilirubinemia (HP:0002908)4.09811493
6Bilateral microphthalmos (HP:0007633)4.05458274
7Abnormal delayed hypersensitivity skin test (HP:0002963)3.83475393
8Abnormality of midbrain morphology (HP:0002418)3.53988977
9Molar tooth sign on MRI (HP:0002419)3.53988977
10Abnormality of the fovea (HP:0000493)3.50225607
11Inability to walk (HP:0002540)3.17166811
12Abolished electroretinogram (ERG) (HP:0000550)3.12904981
13Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.12523125
14Abnormality of alanine metabolism (HP:0010916)3.12523125
15Hyperalaninemia (HP:0003348)3.12523125
16Abnormal drinking behavior (HP:0030082)3.04142948
17Polydipsia (HP:0001959)3.04142948
18True hermaphroditism (HP:0010459)2.99458440
19Panhypogammaglobulinemia (HP:0003139)2.98377841
20Stomatitis (HP:0010280)2.94568720
21Recurrent cutaneous fungal infections (HP:0011370)2.93964904
22Chronic mucocutaneous candidiasis (HP:0002728)2.93964904
23Attenuation of retinal blood vessels (HP:0007843)2.87335365
24Nephronophthisis (HP:0000090)2.80977871
253-Methylglutaconic aciduria (HP:0003535)2.72329316
26Pancreatic cysts (HP:0001737)2.72111223
27Abnormality of T cell physiology (HP:0011840)2.71497058
28Decreased central vision (HP:0007663)2.70285286
29Aplasia/Hypoplasia of the macula (HP:0008059)2.69192283
30Abnormality of the right ventricle (HP:0001707)2.67114791
31Congenital stationary night blindness (HP:0007642)2.63529981
32Abnormality of transition element cation homeostasis (HP:0011030)2.60330074
33Lissencephaly (HP:0001339)2.59006224
34Absent rod-and cone-mediated responses on ERG (HP:0007688)2.57865606
35Failure to thrive in infancy (HP:0001531)2.56333244
36Chronic hepatic failure (HP:0100626)2.55635347
37Aplasia cutis congenita (HP:0001057)2.54307362
38Aplasia/Hypoplasia affecting the retina (HP:0008061)2.52135975
39Abnormality of the renal medulla (HP:0100957)2.43501712
40Polyuria (HP:0000103)2.43442685
41Abnormality of T cells (HP:0002843)2.40248871
42Abnormality of the renal cortex (HP:0011035)2.39436454
43Nephrogenic diabetes insipidus (HP:0009806)2.36705341
44Decreased electroretinogram (ERG) amplitude (HP:0000654)2.33778546
45Elevated erythrocyte sedimentation rate (HP:0003565)2.32720643
46Hip dysplasia (HP:0001385)2.27247050
47Brushfield spots (HP:0001088)2.25455414
48Pancreatic fibrosis (HP:0100732)2.23810854
49Abnormal rod and cone electroretinograms (HP:0008323)2.22427929
50Encephalitis (HP:0002383)2.22260944
51Pustule (HP:0200039)2.22135353
52Tubular atrophy (HP:0000092)2.21853676
53Aplastic anemia (HP:0001915)2.21238669
54Clitoromegaly (HP:0000057)2.19773225
55Abnormality of B cell number (HP:0010975)2.19081436
56Bony spicule pigmentary retinopathy (HP:0007737)2.17984624
57Pendular nystagmus (HP:0012043)2.13096508
58Abnormality of the prostate (HP:0008775)2.12376243
59IgG deficiency (HP:0004315)2.10543194
60Sensorimotor neuropathy (HP:0007141)2.08316197
61Duplicated collecting system (HP:0000081)2.06276358
62Abnormality of T cell number (HP:0011839)2.05620743
63Agammaglobulinemia (HP:0004432)2.05057480
64B lymphocytopenia (HP:0010976)2.02476792
65Female pseudohermaphroditism (HP:0010458)2.00933217
66Hepatitis (HP:0012115)2.00263236
67Lower limb hyperreflexia (HP:0002395)2.00221212
68Recurrent skin infections (HP:0001581)1.95547022
69Abnormality of the renal collecting system (HP:0004742)1.93841948
70Abnormal biliary tract physiology (HP:0012439)1.93546175
71Bile duct proliferation (HP:0001408)1.93546175
72Abnormal urine output (HP:0012590)1.90366682
73Recurrent bacterial skin infections (HP:0005406)1.89047734
74Hypoproteinemia (HP:0003075)1.87387681
75Vacuolated lymphocytes (HP:0001922)1.84617162
76Recurrent fungal infections (HP:0002841)1.83910609
77CNS hypomyelination (HP:0003429)1.83436370
78Abnormality of iron homeostasis (HP:0011031)1.82518588
79Optic neuritis (HP:0100653)1.82282604
80Retrobulbar optic neuritis (HP:0100654)1.82282604
81Widely patent fontanelles and sutures (HP:0004492)1.79629252
82Abnormality of male internal genitalia (HP:0000022)1.78563117
83T lymphocytopenia (HP:0005403)1.77886943
84Abnormality of the clitoris (HP:0000056)1.76220765
85Abnormality of the parietal bone (HP:0002696)1.75922799
86Congenital hepatic fibrosis (HP:0002612)1.75216408
87Hyperglycinuria (HP:0003108)1.74891665
88Progressive cerebellar ataxia (HP:0002073)1.73293766
89Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73059839
90Oligohydramnios (HP:0001562)1.71681384
91Myositis (HP:0100614)1.71421347
92Absent speech (HP:0001344)1.70810138
93Tachypnea (HP:0002789)1.70567483
94Gonadal dysgenesis (HP:0000133)1.70450500
95Male pseudohermaphroditism (HP:0000037)1.69376734
96Recurrent viral infections (HP:0004429)1.67801681
97Medial flaring of the eyebrow (HP:0010747)1.66790432
98Recurrent corneal erosions (HP:0000495)1.64066290
99Keratoconus (HP:0000563)1.63105187
100Increased corneal curvature (HP:0100692)1.63105187

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.18476112
2BMPR24.58734106
3TRIM284.09380008
4SIK33.51524358
5MAP4K23.40043777
6SIK23.19804581
7TLK13.19547208
8PINK12.82518510
9CAMKK22.14485231
10FRK2.12533199
11NEK22.08446259
12BCR1.90738245
13ADRBK21.88869202
14TXK1.77920183
15MAP3K71.71071923
16BCKDK1.63980947
17MAP4K11.60490432
18TAOK31.57529454
19CCNB11.55906056
20FLT31.53654859
21GRK61.45146839
22MARK31.44466210
23BTK1.35327346
24WNK31.35028483
25ACVR1B1.31936278
26TEC1.24242666
27TNIK1.22253674
28DAPK21.20310935
29ERBB31.17060046
30SYK1.16067789
31TNK21.14484802
32MAPK131.13262164
33NUAK11.11817492
34KIT1.09968801
35ZAK1.06837002
36IRAK40.98675385
37PDK20.95297847
38ITK0.92582027
39STK110.92109827
40TAF10.89906311
41VRK20.88814300
42CSF1R0.84050156
43IKBKE0.82009753
44INSRR0.80051328
45CAMK10.79762316
46STK160.78705818
47BMPR1B0.76245471
48CAMK40.74456409
49WNK40.72492059
50CSNK1G20.71216918
51SIK10.67993002
52MATK0.67721830
53STK38L0.67641918
54CDK40.67108282
55MAPKAPK50.66758845
56PIM10.66520695
57GRK10.64982605
58MAP3K110.61986579
59VRK10.59536374
60DYRK30.58738640
61CSNK1G30.57974386
62OXSR10.57369632
63ERBB20.56977971
64MAP2K70.56722022
65IKBKB0.55434376
66PRKAA20.53994168
67LYN0.52061179
68IRAK10.51985869
69LCK0.48011867
70PTK2B0.47956921
71CSNK1A1L0.47339802
72ATR0.46376697
73CAMKK10.46140453
74DYRK1B0.45928352
75HCK0.45889542
76TBK10.43989755
77MAPKAPK30.43431790
78PRKCE0.42931395
79TYK20.42085319
80PRKCQ0.41728056
81ADRBK10.40738524
82CSNK1G10.40023266
83PIK3CG0.39032972
84BLK0.38933301
85PKN10.38573309
86MAP3K40.37843023
87PAK30.37426563
88PRKAA10.37413126
89MARK20.35314630
90PRKD20.34987291
91JAK30.33595106
92RPS6KA50.32781885
93GRK50.32742000
94PRKCI0.31879894
95YES10.30834289
96FES0.30597792
97ABL10.29542139
98IGF1R0.29078891
99TRPM70.27540232
100CHUK0.26853460

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.91074413
2Olfactory transduction_Homo sapiens_hsa047403.21062318
3Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.68928827
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.41781350
5Intestinal immune network for IgA production_Homo sapiens_hsa046722.36484134
6Linoleic acid metabolism_Homo sapiens_hsa005912.35295626
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.30914922
8Asthma_Homo sapiens_hsa053102.23162552
9Phototransduction_Homo sapiens_hsa047442.19145579
10Allograft rejection_Homo sapiens_hsa053302.14976552
11Fanconi anemia pathway_Homo sapiens_hsa034602.09854589
12Primary bile acid biosynthesis_Homo sapiens_hsa001201.96503806
13Autoimmune thyroid disease_Homo sapiens_hsa053201.92590554
14Basal transcription factors_Homo sapiens_hsa030221.91464690
15Histidine metabolism_Homo sapiens_hsa003401.88185436
16Graft-versus-host disease_Homo sapiens_hsa053321.79844665
17Butanoate metabolism_Homo sapiens_hsa006501.78211786
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.68297788
19Nitrogen metabolism_Homo sapiens_hsa009101.65463712
20Selenocompound metabolism_Homo sapiens_hsa004501.63663005
21Ether lipid metabolism_Homo sapiens_hsa005651.61316989
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.51122010
23Hematopoietic cell lineage_Homo sapiens_hsa046401.42961749
24Antigen processing and presentation_Homo sapiens_hsa046121.42205382
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.36666615
26Type I diabetes mellitus_Homo sapiens_hsa049401.33877060
27Renin-angiotensin system_Homo sapiens_hsa046141.31378732
28Caffeine metabolism_Homo sapiens_hsa002321.29648049
29Regulation of autophagy_Homo sapiens_hsa041401.28964493
30Peroxisome_Homo sapiens_hsa041461.28904235
31Fatty acid elongation_Homo sapiens_hsa000621.28640902
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.26802298
33Arachidonic acid metabolism_Homo sapiens_hsa005901.24239088
34NF-kappa B signaling pathway_Homo sapiens_hsa040641.22953651
35African trypanosomiasis_Homo sapiens_hsa051431.16204046
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12266581
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.11970453
38RNA degradation_Homo sapiens_hsa030181.11615523
39Base excision repair_Homo sapiens_hsa034101.09530092
40Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03678074
41Homologous recombination_Homo sapiens_hsa034401.03525244
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.00677742
43Morphine addiction_Homo sapiens_hsa050320.99002781
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.98952838
45Staphylococcus aureus infection_Homo sapiens_hsa051500.97971007
46Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.93898444
47Propanoate metabolism_Homo sapiens_hsa006400.93208070
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.92651323
49Jak-STAT signaling pathway_Homo sapiens_hsa046300.88409228
50Rheumatoid arthritis_Homo sapiens_hsa053230.82029745
51Lysosome_Homo sapiens_hsa041420.79690880
52Long-term depression_Homo sapiens_hsa047300.79144277
53Chemical carcinogenesis_Homo sapiens_hsa052040.79074354
54ABC transporters_Homo sapiens_hsa020100.78956884
55Herpes simplex infection_Homo sapiens_hsa051680.77629842
56Leishmaniasis_Homo sapiens_hsa051400.77361199
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.77239138
58Nicotine addiction_Homo sapiens_hsa050330.72635231
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72066022
60T cell receptor signaling pathway_Homo sapiens_hsa046600.71637931
61Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70850466
62Tryptophan metabolism_Homo sapiens_hsa003800.70553893
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70547371
64Serotonergic synapse_Homo sapiens_hsa047260.70036334
65Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.69479385
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.68574227
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67570767
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.67512771
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65036413
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64451218
71Measles_Homo sapiens_hsa051620.61614527
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59544715
73Choline metabolism in cancer_Homo sapiens_hsa052310.58391092
74Toll-like receptor signaling pathway_Homo sapiens_hsa046200.57606200
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.56007799
76RNA polymerase_Homo sapiens_hsa030200.55728568
77Taste transduction_Homo sapiens_hsa047420.54847495
78Glutamatergic synapse_Homo sapiens_hsa047240.53974297
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.53799357
80Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53233526
81Salivary secretion_Homo sapiens_hsa049700.52942596
82Oxidative phosphorylation_Homo sapiens_hsa001900.49589652
83Tuberculosis_Homo sapiens_hsa051520.48641252
84Nucleotide excision repair_Homo sapiens_hsa034200.46778790
85Calcium signaling pathway_Homo sapiens_hsa040200.46093493
86Sphingolipid metabolism_Homo sapiens_hsa006000.44657075
87GABAergic synapse_Homo sapiens_hsa047270.44512508
88Collecting duct acid secretion_Homo sapiens_hsa049660.44508019
89Pyrimidine metabolism_Homo sapiens_hsa002400.43970307
90Circadian entrainment_Homo sapiens_hsa047130.43664684
91Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41366981
92Retinol metabolism_Homo sapiens_hsa008300.41001402
93Circadian rhythm_Homo sapiens_hsa047100.40937186
94Metabolic pathways_Homo sapiens_hsa011000.39326580
95Glycerolipid metabolism_Homo sapiens_hsa005610.39200295
96Chemokine signaling pathway_Homo sapiens_hsa040620.38831909
97Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.38067437
98Arginine and proline metabolism_Homo sapiens_hsa003300.37200507
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.34967808
100Influenza A_Homo sapiens_hsa051640.34630705

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