CBX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.62859530
2paraxial mesoderm development (GO:0048339)4.42689467
3DNA replication initiation (GO:0006270)4.33830872
4DNA strand elongation involved in DNA replication (GO:0006271)4.31200593
5telomere maintenance via semi-conservative replication (GO:0032201)4.29230423
6kinetochore organization (GO:0051383)4.21498931
7DNA strand elongation (GO:0022616)4.12438280
8DNA unwinding involved in DNA replication (GO:0006268)4.06251395
9ribosomal small subunit biogenesis (GO:0042274)4.05216375
10viral transcription (GO:0019083)4.02521776
11CENP-A containing nucleosome assembly (GO:0034080)3.97102243
12chromatin remodeling at centromere (GO:0031055)3.94512822
13translational termination (GO:0006415)3.93481935
14heterochromatin organization (GO:0070828)3.91182126
15telomere maintenance via recombination (GO:0000722)3.86741661
16maturation of SSU-rRNA (GO:0030490)3.86455902
17kinetochore assembly (GO:0051382)3.85050302
18mitotic recombination (GO:0006312)3.84125933
19mitotic metaphase plate congression (GO:0007080)3.73871565
20ribosomal large subunit biogenesis (GO:0042273)3.68380937
21DNA replication checkpoint (GO:0000076)3.67891155
22DNA replication-dependent nucleosome organization (GO:0034723)3.62019990
23DNA replication-dependent nucleosome assembly (GO:0006335)3.62019990
24regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.61155226
25telomere maintenance via telomere lengthening (GO:0010833)3.57716679
26DNA replication-independent nucleosome organization (GO:0034724)3.57106307
27DNA replication-independent nucleosome assembly (GO:0006336)3.57106307
28protein localization to kinetochore (GO:0034501)3.55825020
29DNA ligation (GO:0006266)3.52488478
30regulation of nuclear cell cycle DNA replication (GO:0033262)3.44091713
31establishment of integrated proviral latency (GO:0075713)3.41989461
32metaphase plate congression (GO:0051310)3.39885448
33nuclear pore organization (GO:0006999)3.39882263
34translational elongation (GO:0006414)3.37417926
35nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.36196883
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.36091627
37nucleotide-excision repair, DNA gap filling (GO:0006297)3.35977853
38regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.32751449
39cotranslational protein targeting to membrane (GO:0006613)3.30133335
40translational initiation (GO:0006413)3.29461046
41ribonucleoprotein complex biogenesis (GO:0022613)3.27413639
42histone exchange (GO:0043486)3.27296492
43protein targeting to ER (GO:0045047)3.27218838
44mitotic sister chromatid segregation (GO:0000070)3.22556371
45nuclear pore complex assembly (GO:0051292)3.20569151
46regulation of helicase activity (GO:0051095)3.18075464
47formation of translation preinitiation complex (GO:0001731)3.17120927
48protein localization to chromosome, centromeric region (GO:0071459)3.15469834
49viral mRNA export from host cell nucleus (GO:0046784)3.12859259
50spliceosomal snRNP assembly (GO:0000387)3.11085333
51DNA damage response, detection of DNA damage (GO:0042769)3.10705175
52protein K6-linked ubiquitination (GO:0085020)3.09813582
53DNA topological change (GO:0006265)3.09626519
54establishment of protein localization to endoplasmic reticulum (GO:0072599)3.08101607
55establishment of chromosome localization (GO:0051303)3.07926201
56viral life cycle (GO:0019058)3.06754598
57sister chromatid segregation (GO:0000819)3.05863489
58cellular protein complex disassembly (GO:0043624)3.05234256
59transcription-coupled nucleotide-excision repair (GO:0006283)3.03459203
60protein localization to endoplasmic reticulum (GO:0070972)3.03059418
61attachment of spindle microtubules to kinetochore (GO:0008608)3.00943588
62mitotic sister chromatid cohesion (GO:0007064)3.00623508
63spliceosomal complex assembly (GO:0000245)2.99723860
64meiotic chromosome segregation (GO:0045132)2.98983303
65regulation of posttranscriptional gene silencing (GO:0060147)2.98626533
66regulation of gene silencing by miRNA (GO:0060964)2.98626533
67regulation of gene silencing by RNA (GO:0060966)2.98626533
68somatic diversification of immune receptors via somatic mutation (GO:0002566)2.98447211
69somatic hypermutation of immunoglobulin genes (GO:0016446)2.98447211
70regulation of double-strand break repair via homologous recombination (GO:0010569)2.98436812
71ATP-dependent chromatin remodeling (GO:0043044)2.98320217
72RNA splicing, via transesterification reactions (GO:0000375)2.96173796
73planar cell polarity pathway involved in neural tube closure (GO:0090179)2.94949008
74rRNA processing (GO:0006364)2.94756396
75mRNA splicing, via spliceosome (GO:0000398)2.93669508
76RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.93669508
77mismatch repair (GO:0006298)2.93029175
78regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.90737121
79protein complex disassembly (GO:0043241)2.89699013
80termination of RNA polymerase II transcription (GO:0006369)2.89499865
81nucleobase biosynthetic process (GO:0046112)2.87961078
82telomere maintenance (GO:0000723)2.87526089
83spindle checkpoint (GO:0031577)2.87198678
84mitotic chromosome condensation (GO:0007076)2.86452332
85nuclear-transcribed mRNA catabolic process (GO:0000956)2.86366004
86notochord development (GO:0030903)2.85897168
87telomere organization (GO:0032200)2.85305265
88DNA duplex unwinding (GO:0032508)2.83791676
89rRNA metabolic process (GO:0016072)2.83191617
90DNA geometric change (GO:0032392)2.83040567
91ribosome assembly (GO:0042255)2.82935535
92ribosome biogenesis (GO:0042254)2.82920978
93convergent extension (GO:0060026)2.81912698
94IMP biosynthetic process (GO:0006188)2.79433757
95establishment of viral latency (GO:0019043)2.78810782
96nucleosome disassembly (GO:0006337)2.78520298
97protein-DNA complex disassembly (GO:0032986)2.78520298
98negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.77668169
99negative regulation of sister chromatid segregation (GO:0033046)2.77668169
100negative regulation of mitotic sister chromatid separation (GO:2000816)2.77668169
101negative regulation of mitotic sister chromatid segregation (GO:0033048)2.77668169
102negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.77437422
103mitotic nuclear envelope disassembly (GO:0007077)2.77334559
104negative regulation of RNA splicing (GO:0033119)2.77106176
105negative regulation of chromosome segregation (GO:0051985)2.77099164
106pseudouridine synthesis (GO:0001522)2.76014942
107intra-S DNA damage checkpoint (GO:0031573)2.75909830
108exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.75730043
109proteasome assembly (GO:0043248)2.75500092
110chromatin assembly or disassembly (GO:0006333)2.74946133
111regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.73950229
112protein complex localization (GO:0031503)2.64022093
113pre-miRNA processing (GO:0031054)2.62305638
114cell migration in hindbrain (GO:0021535)2.52516211
115regulation of chromosome segregation (GO:0051983)2.52511222
116regulation of centriole replication (GO:0046599)2.52252258
117positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.52080814
118positive regulation of cell cycle G2/M phase transition (GO:1902751)2.52080814
119chromatin assembly (GO:0031497)2.47092837
120regulation of mitotic spindle organization (GO:0060236)2.45577244
121generation of neurons (GO:0048699)2.45265838
122chromosome condensation (GO:0030261)2.41927343
123body morphogenesis (GO:0010171)2.40556761
124regulation of spindle organization (GO:0090224)2.40307476
125macromolecular complex disassembly (GO:0032984)2.38264767
126protein localization to chromosome (GO:0034502)2.35284164
127regulation of translational fidelity (GO:0006450)2.32707198
128negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.32096056
129L-serine metabolic process (GO:0006563)2.31909774
130regulation of sister chromatid cohesion (GO:0007063)2.31882848
131pore complex assembly (GO:0046931)2.29747772
132mitotic spindle checkpoint (GO:0071174)2.27792855
133histone H2B ubiquitination (GO:0033523)2.27656998
134embryonic body morphogenesis (GO:0010172)2.26928084
135regulation of centrosome cycle (GO:0046605)2.26910461
136Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.25383160
137positive regulation of chromosome segregation (GO:0051984)2.25080601
138G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.24807421
139mitotic spindle organization (GO:0007052)2.24319408
140apical protein localization (GO:0045176)2.21870507
141establishment of monopolar cell polarity (GO:0061162)2.21536959
142establishment or maintenance of monopolar cell polarity (GO:0061339)2.21536959
143chromosome segregation (GO:0007059)2.21334421
144establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.20327366
145pyrimidine nucleobase catabolic process (GO:0006208)2.19863880
146mitotic cytokinesis (GO:0000281)2.19696099
147mitotic spindle assembly checkpoint (GO:0007094)2.19661909

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.56791531
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.29475731
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.28799689
4MYC_18555785_ChIP-Seq_MESCs_Mouse4.27852380
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.63672754
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.30094910
7MYC_19079543_ChIP-ChIP_MESCs_Mouse3.01702337
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.98247049
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.87882734
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.81057524
11SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.70076159
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.69406760
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.60148910
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.57287654
15NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.57049060
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.56206746
17TP63_19390658_ChIP-ChIP_HaCaT_Human2.52240778
18* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.51228704
19* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.42855036
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39277703
21* ETS1_20019798_ChIP-Seq_JURKAT_Human2.36813325
22JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.34291067
23* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27592460
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.23070688
25XRN2_22483619_ChIP-Seq_HELA_Human2.21804113
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.09289075
27* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.09217033
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.09088598
29VDR_23849224_ChIP-Seq_CD4+_Human2.05067896
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.05030291
31E2F1_21310950_ChIP-Seq_MCF-7_Human1.98005984
32ELK1_19687146_ChIP-ChIP_HELA_Human1.96749890
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.96171593
34TTF2_22483619_ChIP-Seq_HELA_Human1.92275910
35NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.89722877
36KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.89699427
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.89699427
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.89699427
39* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.89534220
40FOXP3_21729870_ChIP-Seq_TREG_Human1.89100036
41SOX2_18555785_ChIP-Seq_MESCs_Mouse1.86529403
42* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.85977850
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84356183
44AR_21909140_ChIP-Seq_LNCAP_Human1.84074176
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.84055606
46* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.79328491
47MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.77011744
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.75611736
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73351563
50DCP1A_22483619_ChIP-Seq_HELA_Human1.72562031
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69888860
52EZH2_22144423_ChIP-Seq_EOC_Human1.69456514
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.68647816
54SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.65740914
55ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.62255302
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.62198987
57* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.56828618
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56776383
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.54485640
60KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.53665046
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51990221
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.51852740
63CIITA_25753668_ChIP-Seq_RAJI_Human1.49398859
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48910223
65CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.48335827
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.45947526
67* GABP_19822575_ChIP-Seq_HepG2_Human1.41791440
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40064059
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39468603
70IRF1_19129219_ChIP-ChIP_H3396_Human1.38702683
71GATA1_26923725_Chip-Seq_HPCs_Mouse1.37979104
72* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37364347
73SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.36857438
74* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.35550726
75* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.31333142
76* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29071661
77MYC_18940864_ChIP-ChIP_HL60_Human1.28368769
78CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.25882335
79RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.24381480
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.23536320
81ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22158104
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21140717
83* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20582082
84* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.18744098
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17790944
86KDM5A_27292631_Chip-Seq_BREAST_Human1.16761754
87* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.16182238
88* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15752860
89WT1_19549856_ChIP-ChIP_CCG9911_Human1.15693261
90* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.14895730
91EZH2_27304074_Chip-Seq_ESCs_Mouse1.12038129
92* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.11894331
93SRF_21415370_ChIP-Seq_HL-1_Mouse1.10945159
94* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.10445316
95PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08898284
96KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07013564
97SOX2_16153702_ChIP-ChIP_HESCs_Human1.06174781
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03997980
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03337892
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02566654
101NANOG_16153702_ChIP-ChIP_HESCs_Human1.02283979
102* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00943398
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.98083889
104MYC_22102868_ChIP-Seq_BL_Human0.96168821
105E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95430321
106* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.95357227
107* SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.95310888
108CBX2_27304074_Chip-Seq_ESCs_Mouse0.94893534
109* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.94801557
110SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94561673
111SOX9_26525672_Chip-Seq_HEART_Mouse0.93796913
112* NANOG_21062744_ChIP-ChIP_HESCs_Human0.93574993
113* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.92868107
114OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92259846
115SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91903394
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.91343163
117NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.91208466
118* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90354392
119NOTCH1_21737748_ChIP-Seq_TLL_Human0.90040723
120CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89863893
121ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.89605788
122ERG_21242973_ChIP-ChIP_JURKAT_Human0.88373986
123RING1B_27294783_Chip-Seq_NPCs_Mouse0.87835713
124STAT3_1855785_ChIP-Seq_MESCs_Mouse0.87326368
125CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86984346
126RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.86337859
127DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.86264814
128FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.85879039
129ELK1_22589737_ChIP-Seq_MCF10A_Human0.85565878
130ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84510151
131HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.84418471
132SOX17_20123909_ChIP-Seq_XEN_Mouse0.83133338
133BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.82341132
134PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.78969816

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.04681889
2MP0010094_abnormal_chromosome_stability3.78717679
3MP0008057_abnormal_DNA_replication3.55436766
4MP0004957_abnormal_blastocyst_morpholog3.49655227
5MP0003111_abnormal_nucleus_morphology3.29243227
6MP0003077_abnormal_cell_cycle3.21033335
7MP0008058_abnormal_DNA_repair2.94135166
8MP0006292_abnormal_olfactory_placode2.88029369
9MP0003123_paternal_imprinting2.81221550
10MP0008007_abnormal_cellular_replicative2.43445519
11MP0008932_abnormal_embryonic_tissue2.39374018
12MP0000566_synostosis2.38217903
13MP0009379_abnormal_foot_pigmentation2.27080255
14MP0003121_genomic_imprinting2.20102338
15MP0003136_yellow_coat_color2.08431096
16MP0003315_abnormal_perineum_morphology2.01726677
17MP0010030_abnormal_orbit_morphology1.99539509
18MP0000778_abnormal_nervous_system1.97489053
19MP0002938_white_spotting1.74827009
20MP0000350_abnormal_cell_proliferation1.73453965
21MP0000049_abnormal_middle_ear1.67870536
22MP0003786_premature_aging1.67777087
23MP0003941_abnormal_skin_development1.62831079
24MP0001293_anophthalmia1.58591956
25MP0003937_abnormal_limbs/digits/tail_de1.55839420
26MP0003890_abnormal_embryonic-extraembry1.54259874
27MP0008877_abnormal_DNA_methylation1.52078461
28MP0002085_abnormal_embryonic_tissue1.51279882
29MP0001730_embryonic_growth_arrest1.47757009
30MP0001672_abnormal_embryogenesis/_devel1.46446685
31MP0005380_embryogenesis_phenotype1.46446685
32MP0002249_abnormal_larynx_morphology1.43353271
33MP0001299_abnormal_eye_distance/1.43281158
34MP0003567_abnormal_fetal_cardiomyocyte1.42822965
35MP0003787_abnormal_imprinting1.42759933
36MP0002396_abnormal_hematopoietic_system1.41773072
37MP0004859_abnormal_synaptic_plasticity1.40473404
38MP0009672_abnormal_birth_weight1.38232810
39MP0003119_abnormal_digestive_system1.36952251
40MP0000490_abnormal_crypts_of1.35835564
41MP0005257_abnormal_intraocular_pressure1.34784818
42MP0001697_abnormal_embryo_size1.34627589
43MP0003938_abnormal_ear_development1.33176426
44MP0004197_abnormal_fetal_growth/weight/1.33046033
45MP0008789_abnormal_olfactory_epithelium1.32562004
46MP0004133_heterotaxia1.29685808
47MP0002084_abnormal_developmental_patter1.29336259
48MP0003705_abnormal_hypodermis_morpholog1.25414767
49MP0009053_abnormal_anal_canal1.24886427
50MP0000534_abnormal_ureter_morphology1.24658879
51MP0003385_abnormal_body_wall1.24032600
52MP0001188_hyperpigmentation1.22132831
53MP0003984_embryonic_growth_retardation1.22122788
54MP0002751_abnormal_autonomic_nervous1.22118723
55MP0001286_abnormal_eye_development1.21384545
56MP0002088_abnormal_embryonic_growth/wei1.21107715
57MP0005409_darkened_coat_color1.19779118
58MP0000579_abnormal_nail_morphology1.18964524
59MP0003718_maternal_effect1.17747607
60MP0000955_abnormal_spinal_cord1.17571110
61MP0001529_abnormal_vocalization1.14928545
62MP0002184_abnormal_innervation1.13736614
63MP0003122_maternal_imprinting1.12391456
64MP0002080_prenatal_lethality1.11489604
65MP0000313_abnormal_cell_death1.09798178
66MP0002210_abnormal_sex_determination1.09571924
67MP0004270_analgesia1.07985050
68MP0002160_abnormal_reproductive_system1.07138545
69MP0001346_abnormal_lacrimal_gland1.06865558
70MP0005174_abnormal_tail_pigmentation1.05264145
71MP0002152_abnormal_brain_morphology1.04680019
72MP0002086_abnormal_extraembryonic_tissu1.04205111
73MP0003755_abnormal_palate_morphology1.04154961
74MP0000537_abnormal_urethra_morphology1.03249103
75MP0002081_perinatal_lethality1.01982823
76MP0003942_abnormal_urinary_system1.00018964
77MP0010352_gastrointestinal_tract_polyps0.99860508
78MP0002234_abnormal_pharynx_morphology0.98879576
79MP0000015_abnormal_ear_pigmentation0.98335799
80MP0002111_abnormal_tail_morphology0.97375242
81MP0005187_abnormal_penis_morphology0.96786126
82MP0000631_abnormal_neuroendocrine_gland0.96588741
83MP0004808_abnormal_hematopoietic_stem0.96491668
84MP0002277_abnormal_respiratory_mucosa0.96134158
85MP0000432_abnormal_head_morphology0.95484980
86MP0005075_abnormal_melanosome_morpholog0.94790789
87MP0005623_abnormal_meninges_morphology0.94719958
88MP0005499_abnormal_olfactory_system0.94433123
89MP0005394_taste/olfaction_phenotype0.94433123
90MP0002019_abnormal_tumor_incidence0.94198389
91MP0001119_abnormal_female_reproductive0.94071255
92MP0003115_abnormal_respiratory_system0.93995372
93MP0005248_abnormal_Harderian_gland0.93857350
94MP0000678_abnormal_parathyroid_gland0.93581475
95MP0003935_abnormal_craniofacial_develop0.93574464
96MP0005389_reproductive_system_phenotype0.93458342
97MP0002095_abnormal_skin_pigmentation0.93079903
98MP0001145_abnormal_male_reproductive0.91319209
99MP0009250_abnormal_appendicular_skeleto0.91291689
100MP0003763_abnormal_thymus_physiology0.91022034
101MP0004811_abnormal_neuron_physiology0.90719513
102MP0002102_abnormal_ear_morphology0.88445373
103MP0009703_decreased_birth_body0.87966070
104MP0002132_abnormal_respiratory_system0.87960629
105MP0002177_abnormal_outer_ear0.87730310
106MP0002092_abnormal_eye_morphology0.86064595
107MP0000428_abnormal_craniofacial_morphol0.85764528
108MP0002638_abnormal_pupillary_reflex0.85209103
109MP0002233_abnormal_nose_morphology0.85207481
110MP0010307_abnormal_tumor_latency0.85180592
111MP0002282_abnormal_trachea_morphology0.84925056
112MP0002114_abnormal_axial_skeleton0.84496735
113MP0002116_abnormal_craniofacial_bone0.82738899
114MP0002822_catalepsy0.82584681
115MP0000762_abnormal_tongue_morphology0.82260675
116MP0005423_abnormal_somatic_nervous0.82037309
117MP0002932_abnormal_joint_morphology0.81857666
118MP0001340_abnormal_eyelid_morphology0.81480632
119MP0002697_abnormal_eye_size0.80450920
120MP0002163_abnormal_gland_morphology0.79753795
121MP0002009_preneoplasia0.79738363
122MP0003861_abnormal_nervous_system0.79572442
123MP0004858_abnormal_nervous_system0.79516119
124MP0005367_renal/urinary_system_phenotyp0.79338784
125MP0000516_abnormal_urinary_system0.79338784
126MP0005391_vision/eye_phenotype0.79162838
127MP0001919_abnormal_reproductive_system0.78907233
128MP0000653_abnormal_sex_gland0.78548138
129MP0003880_abnormal_central_pattern0.78279852
130MP0002882_abnormal_neuron_morphology0.77782602
131MP0000703_abnormal_thymus_morphology0.76812655

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.02264021
2Chromosomal breakage induced by crosslinking agents (HP:0003221)3.84408742
3Chromsome breakage (HP:0040012)3.81644126
4Birth length less than 3rd percentile (HP:0003561)3.31706795
5Abnormal lung lobation (HP:0002101)3.29100948
6Supernumerary spleens (HP:0009799)3.27044089
7Nephroblastoma (Wilms tumor) (HP:0002667)3.26802614
8Medulloblastoma (HP:0002885)3.21069128
9Abnormality of cells of the erythroid lineage (HP:0012130)3.19159332
10Meckel diverticulum (HP:0002245)3.17367175
11Cortical dysplasia (HP:0002539)3.08783511
12Patellar aplasia (HP:0006443)3.07876756
13Embryonal renal neoplasm (HP:0011794)3.07845874
14Abnormality of the ileum (HP:0001549)2.98983129
15Abnormal number of erythroid precursors (HP:0012131)2.97883701
16Aplasia/Hypoplasia of the patella (HP:0006498)2.92855152
17Colon cancer (HP:0003003)2.88993270
18Abnormality of chromosome stability (HP:0003220)2.81870934
19Rhabdomyosarcoma (HP:0002859)2.80898750
20Increased nuchal translucency (HP:0010880)2.76808338
21Breast hypoplasia (HP:0003187)2.72635444
22Aplasia/Hypoplasia of the uvula (HP:0010293)2.69996793
23Abnormality of the preputium (HP:0100587)2.67936332
24Type I transferrin isoform profile (HP:0003642)2.63795540
25Abnormal number of incisors (HP:0011064)2.63182649
26Ectopic kidney (HP:0000086)2.58929006
27Absent radius (HP:0003974)2.58795308
28Aplastic anemia (HP:0001915)2.55926611
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.51438188
30Selective tooth agenesis (HP:0001592)2.47787550
31Triphalangeal thumb (HP:0001199)2.46940335
32Rib fusion (HP:0000902)2.45717134
33Small intestinal stenosis (HP:0012848)2.44565606
34Duodenal stenosis (HP:0100867)2.44565606
35Aplasia involving forearm bones (HP:0009822)2.44247928
36Absent forearm bone (HP:0003953)2.44247928
37Absent thumb (HP:0009777)2.36047432
38Macrocytic anemia (HP:0001972)2.32471364
39Impulsivity (HP:0100710)2.32337375
4011 pairs of ribs (HP:0000878)2.32204285
41Pallor (HP:0000980)2.25939940
42Ependymoma (HP:0002888)2.23703984
43Oral leukoplakia (HP:0002745)2.21634311
44Supernumerary bones of the axial skeleton (HP:0009144)2.19935439
45Abnormality of the labia minora (HP:0012880)2.18646207
46Coronal craniosynostosis (HP:0004440)2.18610990
47Hepatoblastoma (HP:0002884)2.18577142
48Myelodysplasia (HP:0002863)2.17068418
49Duplicated collecting system (HP:0000081)2.17056758
50Atresia of the external auditory canal (HP:0000413)2.16496110
51Overriding aorta (HP:0002623)2.16250627
52Diastasis recti (HP:0001540)2.14952455
53Abnormality of the duodenum (HP:0002246)2.13862797
54Abnormality of the renal collecting system (HP:0004742)2.09629957
55Supernumerary ribs (HP:0005815)2.08774158
56Neoplasm of striated muscle (HP:0009728)2.06695601
57Sloping forehead (HP:0000340)2.06135221
58Asplenia (HP:0001746)2.05204732
59Duplication of thumb phalanx (HP:0009942)2.01536896
60Carpal bone hypoplasia (HP:0001498)2.01344778
61Absent septum pellucidum (HP:0001331)2.01131157
62Tracheoesophageal fistula (HP:0002575)1.98740238
63Turricephaly (HP:0000262)1.98727164
64Anophthalmia (HP:0000528)1.97876203
65Volvulus (HP:0002580)1.97821884
66Aplasia/Hypoplasia of the spleen (HP:0010451)1.95977819
67Premature graying of hair (HP:0002216)1.95358290
68Rectal fistula (HP:0100590)1.94684198
69Rectovaginal fistula (HP:0000143)1.94684198
70Agnosia (HP:0010524)1.94111752
71Bone marrow hypocellularity (HP:0005528)1.93613180
72Abnormality of the anterior horn cell (HP:0006802)1.92639145
73Degeneration of anterior horn cells (HP:0002398)1.92639145
74Aplasia/Hypoplasia of the sternum (HP:0006714)1.92475106
75Cutaneous finger syndactyly (HP:0010554)1.92392256
76Horseshoe kidney (HP:0000085)1.91249153
77Hyperacusis (HP:0010780)1.91023198
78Intestinal atresia (HP:0011100)1.90701978
79Optic nerve coloboma (HP:0000588)1.90527664
80Cutaneous syndactyly (HP:0012725)1.89951879
81Shallow orbits (HP:0000586)1.87281643
82Insomnia (HP:0100785)1.86713890
83Abdominal situs inversus (HP:0003363)1.86446731
84Abnormality of abdominal situs (HP:0011620)1.86446731
85Cleft eyelid (HP:0000625)1.86386231
86Renal duplication (HP:0000075)1.86185665
87Short thumb (HP:0009778)1.85251943
88Septo-optic dysplasia (HP:0100842)1.84904764
89Maternal diabetes (HP:0009800)1.84886359
90Hypoplasia of the radius (HP:0002984)1.83313992
91Stenosis of the external auditory canal (HP:0000402)1.83151206
92Missing ribs (HP:0000921)1.83078206
93Partial duplication of the phalanx of hand (HP:0009999)1.82689614
94Elfin facies (HP:0004428)1.81701654
95Esophageal atresia (HP:0002032)1.81048528
96Short middle phalanx of the 5th finger (HP:0004220)1.78595684
97Clubbing of toes (HP:0100760)1.78541993
98Vertebral arch anomaly (HP:0008438)1.78395362
99Generalized hypotonia (HP:0001290)1.78183921
100Abnormality of the incisor (HP:0000676)1.77805473
101Partial duplication of thumb phalanx (HP:0009944)1.77169751
102Proximal placement of thumb (HP:0009623)1.77044108
103Short 4th metacarpal (HP:0010044)1.76962907
104Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.76962907
105Oligodactyly (HP:0012165)1.76945843
106Trigonocephaly (HP:0000243)1.76773712
107Neoplasm of the pancreas (HP:0002894)1.76491740
108Reduced antithrombin III activity (HP:0001976)1.76239561
109Myelomeningocele (HP:0002475)1.76070579
110Aplasia/Hypoplasia of the breasts (HP:0010311)1.73918716
111Anencephaly (HP:0002323)1.73807496
112Intestinal fistula (HP:0100819)1.73726258
113Abnormality of DNA repair (HP:0003254)1.73192900
114Abnormality of the phalanges of the hallux (HP:0010057)1.72956752
115Abnormality of the septum pellucidum (HP:0007375)1.72730363
116Asymmetry of the thorax (HP:0001555)1.72435661
117Rough bone trabeculation (HP:0100670)1.71720079
118Facial cleft (HP:0002006)1.71399358
119Hypoplastic pelvis (HP:0008839)1.70761507
120Preaxial hand polydactyly (HP:0001177)1.70493591
121Myokymia (HP:0002411)1.70249591
122High anterior hairline (HP:0009890)1.69407337
123Midline defect of the nose (HP:0004122)1.69155190
124Deviation of the thumb (HP:0009603)1.69121236
125Hemivertebrae (HP:0002937)1.69006409
126True hermaphroditism (HP:0010459)1.67624919
127Embryonal neoplasm (HP:0002898)1.66820571
128Abnormal sex determination (HP:0012244)1.66496557
129Sex reversal (HP:0012245)1.66496557
130Calcaneovalgus deformity (HP:0001848)1.65953304
131Bilateral microphthalmos (HP:0007633)1.65724497
132Omphalocele (HP:0001539)1.63648280
133Abnormality of the calcaneus (HP:0008364)1.63440573
134Multiple enchondromatosis (HP:0005701)1.59522713
135Choanal stenosis (HP:0000452)1.59392743
136Overlapping toe (HP:0001845)1.55211750
137Renovascular hypertension (HP:0100817)1.55204937
138Arnold-Chiari malformation (HP:0002308)1.53941542
139Aqueductal stenosis (HP:0002410)1.51964833
140Abnormality of the carotid arteries (HP:0005344)1.51728092
141Broad thumb (HP:0011304)1.50699999
142Abnormality of the parietal bone (HP:0002696)1.50622820
143Morphological abnormality of the middle ear (HP:0008609)1.49758554
144Abnormality of the antihelix (HP:0009738)1.49545014
145Obsessive-compulsive behavior (HP:0000722)1.49472170
146Aplasia of the phalanges of the hand (HP:0009802)1.49398877
147Aplasia involving bones of the extremities (HP:0009825)1.49398877
148Aplasia involving bones of the upper limbs (HP:0009823)1.49398877
149Abnormality of the diencephalon (HP:0010662)1.47847503
150Abnormality of the 4th metacarpal (HP:0010012)1.46426782
151Breast aplasia (HP:0100783)1.46091675
152Deformed tarsal bones (HP:0008119)1.44451863
153Oligodactyly (hands) (HP:0001180)1.44274822
154Partial agenesis of the corpus callosum (HP:0001338)1.43826352
155Glossoptosis (HP:0000162)1.42302636
156Absent eyebrow (HP:0002223)1.41767199

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.95983678
2BUB13.68239440
3SRPK13.67071389
4WEE13.49612493
5MKNK13.49255941
6MKNK23.46229721
7EIF2AK32.65065424
8LATS22.32462100
9TTK2.26716926
10NME22.25015120
11TLK12.12845127
12EIF2AK12.11808198
13NLK1.98013831
14CDK121.97973489
15VRK11.96641554
16NEK21.93960572
17ACVR1B1.90410530
18VRK21.88257190
19PASK1.82119884
20PLK11.76192851
21CDK71.75385362
22PLK41.74023269
23EPHB21.73964564
24MARK11.73941373
25CLK11.69770678
26TAF11.65926241
27NTRK11.63045596
28BRSK21.61006539
29PLK31.59652786
30RPS6KB21.56178723
31CHEK21.52449649
32ATR1.52191460
33AURKB1.48909109
34STK161.48301435
35TSSK61.47975250
36YES11.43646980
37LATS11.42957638
38DYRK31.40526358
39EIF2AK21.40031540
40ZAK1.37635720
41CDK41.36324809
42MAP3K91.25708059
43BRD41.22684117
44TYRO31.21742840
45EPHA21.16911342
46MAP2K71.16528826
47TGFBR11.15360331
48NTRK21.15343011
49STK41.13907602
50EEF2K1.12013751
51PBK1.11870977
52CAMK1G1.10852336
53PRKD31.08268533
54CHEK11.07163881
55AURKA1.05805375
56CDK81.03961295
57CDK191.01978567
58MST40.98637006
59ICK0.98432657
60PDGFRA0.95173448
61ATM0.94525296
62PIM10.93529374
63TESK20.93248007
64CDK11A0.90288558
65NME10.88393219
66CDK150.88230450
67CDK180.87515927
68SMG10.87510986
69CSNK1G10.85502718
70MAP3K40.84278867
71FGFR10.82271452
72MINK10.82064203
73CSNK1E0.81912554
74STK100.80922606
75CDK140.80774902
76DYRK20.79969799
77KSR10.79283791
78MAP3K80.79119746
79BRSK10.78956580
80RPS6KA40.78847987
81CDK20.78710047
82RPS6KA50.78278624
83DMPK0.78052526
84FGFR20.76483434
85MELK0.75608916
86STK38L0.75484198
87CDK60.73115621
88* CSNK2A10.71870055
89ERBB40.71744630
90PTK20.71205786
91TRIB30.70579025
92LIMK10.69483510
93IRAK40.69324858
94CSNK2A20.68593786
95CDK10.68221697
96TNIK0.68116113
97CSNK1G20.62698525
98CASK0.62051702
99ERBB30.61367824
100NUAK10.60893599
101MUSK0.60375767
102ADRBK20.60120304
103MET0.59459731
104PRKCG0.57617557
105ARAF0.57307698
106TRIM280.55929609
107MTOR0.55791041
108CCNB10.55256241
109NEK10.54833758
110STK30.54106476
111PRKCI0.52827985
112PAK40.52153611
113UHMK10.51586216
114CAMK1D0.51388995
115EPHA40.51245214
116PAK10.50010057
117WNK40.49301521
118MAP3K100.46764078
119BMPR1B0.45761612
120BCR0.45260113
121AKT20.44908707
122CSNK1G30.44179776
123TEC0.43727306
124SCYL20.43547765
125PKN20.42842062
126AKT30.42244820
127BRAF0.41638666
128TAOK20.39662430
129RPS6KA60.37715016
130CSNK1D0.34267623
131DYRK1A0.34003777
132GRK60.33322651
133FLT30.33115242
134MAPK130.32890788
135AKT10.32668646
136RPS6KL10.32512321
137RPS6KC10.32512321
138PRKDC0.32497954
139BTK0.32314959
140CDK30.32119354
141MAPK140.31432682
142PNCK0.31044463
143CSF1R0.28346534
144ALK0.28089727
145CSNK1A1L0.26280003
146RPS6KB10.25563726

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.69812206
2Mismatch repair_Homo sapiens_hsa034304.23529260
3Ribosome_Homo sapiens_hsa030104.01813892
4Spliceosome_Homo sapiens_hsa030403.61336971
5Homologous recombination_Homo sapiens_hsa034403.37213209
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.20904762
7RNA polymerase_Homo sapiens_hsa030203.08874142
8Base excision repair_Homo sapiens_hsa034103.04397042
9Nucleotide excision repair_Homo sapiens_hsa034202.90220527
10RNA transport_Homo sapiens_hsa030132.75764081
11Proteasome_Homo sapiens_hsa030502.63872915
12Cell cycle_Homo sapiens_hsa041102.63035636
13Fanconi anemia pathway_Homo sapiens_hsa034602.62124149
14Non-homologous end-joining_Homo sapiens_hsa034502.29814878
15One carbon pool by folate_Homo sapiens_hsa006702.28347729
16Pyrimidine metabolism_Homo sapiens_hsa002402.27417078
17Basal transcription factors_Homo sapiens_hsa030222.19595647
18RNA degradation_Homo sapiens_hsa030182.13148589
19mRNA surveillance pathway_Homo sapiens_hsa030151.95218517
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.62193320
21p53 signaling pathway_Homo sapiens_hsa041151.42297890
22Axon guidance_Homo sapiens_hsa043601.31543115
23Protein export_Homo sapiens_hsa030601.31391863
24Systemic lupus erythematosus_Homo sapiens_hsa053221.30396439
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23033574
26Purine metabolism_Homo sapiens_hsa002301.22957387
27Basal cell carcinoma_Homo sapiens_hsa052171.21945751
28Biosynthesis of amino acids_Homo sapiens_hsa012301.18817385
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.11877811
30Cardiac muscle contraction_Homo sapiens_hsa042601.07978010
31Steroid biosynthesis_Homo sapiens_hsa001001.07432876
32Epstein-Barr virus infection_Homo sapiens_hsa051691.04829757
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.04109165
34Melanogenesis_Homo sapiens_hsa049161.00671311
35Herpes simplex infection_Homo sapiens_hsa051681.00266997
36Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97465444
37Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96077263
38Cysteine and methionine metabolism_Homo sapiens_hsa002700.95911851
39Nicotine addiction_Homo sapiens_hsa050330.94404091
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92956729
41Central carbon metabolism in cancer_Homo sapiens_hsa052300.92353216
42Thyroid cancer_Homo sapiens_hsa052160.89645846
43MicroRNAs in cancer_Homo sapiens_hsa052060.87352037
44Pyruvate metabolism_Homo sapiens_hsa006200.86971544
45Vitamin B6 metabolism_Homo sapiens_hsa007500.79700294
46Viral carcinogenesis_Homo sapiens_hsa052030.79220605
47Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79002537
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78208595
49Alzheimers disease_Homo sapiens_hsa050100.76429236
50Lysine degradation_Homo sapiens_hsa003100.75508585
51HTLV-I infection_Homo sapiens_hsa051660.73955326
52Hippo signaling pathway_Homo sapiens_hsa043900.72685102
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72228307
54Hedgehog signaling pathway_Homo sapiens_hsa043400.71415627
55Notch signaling pathway_Homo sapiens_hsa043300.71289287
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70841154
57Gap junction_Homo sapiens_hsa045400.70199273
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.68467261
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68122454
60ErbB signaling pathway_Homo sapiens_hsa040120.67429761
61Huntingtons disease_Homo sapiens_hsa050160.67286826
62Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66649294
63Oocyte meiosis_Homo sapiens_hsa041140.66408496
64TGF-beta signaling pathway_Homo sapiens_hsa043500.65625108
65Primary immunodeficiency_Homo sapiens_hsa053400.64978889
66Arachidonic acid metabolism_Homo sapiens_hsa005900.64870178
67Antigen processing and presentation_Homo sapiens_hsa046120.64600406
68Wnt signaling pathway_Homo sapiens_hsa043100.61813496
69Carbon metabolism_Homo sapiens_hsa012000.60599627
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57782425
71Colorectal cancer_Homo sapiens_hsa052100.56989237
72Prostate cancer_Homo sapiens_hsa052150.55061472
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54882251
74Alcoholism_Homo sapiens_hsa050340.54841811
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54792615
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53313895
77Renal cell carcinoma_Homo sapiens_hsa052110.52828109
78Cocaine addiction_Homo sapiens_hsa050300.52213219
79Small cell lung cancer_Homo sapiens_hsa052220.52184777
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51889318
81Dopaminergic synapse_Homo sapiens_hsa047280.50715602
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.49142965
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.49091818
84Pathways in cancer_Homo sapiens_hsa052000.49062208
85Proteoglycans in cancer_Homo sapiens_hsa052050.48483295
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47818087
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45873787
88Asthma_Homo sapiens_hsa053100.45780467
89Sulfur relay system_Homo sapiens_hsa041220.45537089
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45514454
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.45334757
92Measles_Homo sapiens_hsa051620.45152716
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44652040
94Glioma_Homo sapiens_hsa052140.44642461
95Parkinsons disease_Homo sapiens_hsa050120.44299245
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43716577
97Dilated cardiomyopathy_Homo sapiens_hsa054140.43630642
98Glutamatergic synapse_Homo sapiens_hsa047240.42810978
99ECM-receptor interaction_Homo sapiens_hsa045120.42546579
100Adherens junction_Homo sapiens_hsa045200.40770977
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.40662628
102Propanoate metabolism_Homo sapiens_hsa006400.40269956
103Arginine and proline metabolism_Homo sapiens_hsa003300.40047119
104Pentose phosphate pathway_Homo sapiens_hsa000300.39372475
105N-Glycan biosynthesis_Homo sapiens_hsa005100.39072972
106Allograft rejection_Homo sapiens_hsa053300.38389176
107AMPK signaling pathway_Homo sapiens_hsa041520.38311369
108Intestinal immune network for IgA production_Homo sapiens_hsa046720.37748245
109Rap1 signaling pathway_Homo sapiens_hsa040150.37671430
110Graft-versus-host disease_Homo sapiens_hsa053320.37416827
111Glutathione metabolism_Homo sapiens_hsa004800.37291030
112Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33040197
113Autoimmune thyroid disease_Homo sapiens_hsa053200.32808610
114Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32392666
115Hematopoietic cell lineage_Homo sapiens_hsa046400.32259610
116Oxidative phosphorylation_Homo sapiens_hsa001900.32000431
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.30700187
118Apoptosis_Homo sapiens_hsa042100.30697939
119Hepatitis B_Homo sapiens_hsa051610.30423925
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29459562
121Melanoma_Homo sapiens_hsa052180.27372682
122Legionellosis_Homo sapiens_hsa051340.27093195
123Phototransduction_Homo sapiens_hsa047440.24560824
124Folate biosynthesis_Homo sapiens_hsa007900.24245416
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24165849
126Cyanoamino acid metabolism_Homo sapiens_hsa004600.24084097
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23162100
128RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.22713750
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.22006516
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21603902
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.21541528
132Influenza A_Homo sapiens_hsa051640.21518102
133Selenocompound metabolism_Homo sapiens_hsa004500.21177562
134Linoleic acid metabolism_Homo sapiens_hsa005910.20074257
135Tight junction_Homo sapiens_hsa045300.19588022
136Bladder cancer_Homo sapiens_hsa052190.19110668
137Acute myeloid leukemia_Homo sapiens_hsa052210.18505891
138Ether lipid metabolism_Homo sapiens_hsa005650.16770040
139Viral myocarditis_Homo sapiens_hsa054160.16422865
140Endometrial cancer_Homo sapiens_hsa052130.13764107
141Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.12765361
142Metabolic pathways_Homo sapiens_hsa011000.12551072
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.12362332
144Chronic myeloid leukemia_Homo sapiens_hsa052200.10885672
145Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.10524040
146FoxO signaling pathway_Homo sapiens_hsa040680.09740229

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