CBLN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cerebellum-specific precursor protein, precerebellin, with similarity to the globular (non-collagen-like) domain of complement component C1qB. Precerebellin is processed to give rise to several derivatives, including the hexadecapeptide, cerebellin, which is highly enriched in postsynaptic structures of Purkinje cells. Cerebellin has also been found in human and rat adrenals, where it has been shown to enhance the secretory activity of this gland. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to pheromone (GO:0019236)8.46822101
2cerebellar Purkinje cell differentiation (GO:0021702)6.58783483
3locomotory exploration behavior (GO:0035641)6.50908438
4neuronal action potential propagation (GO:0019227)6.47519101
5G-protein coupled glutamate receptor signaling pathway (GO:0007216)6.33023989
6gamma-aminobutyric acid transport (GO:0015812)6.21057475
7cellular potassium ion homeostasis (GO:0030007)6.13461692
8sodium ion export (GO:0071436)6.05494507
9* cerebellar granule cell differentiation (GO:0021707)6.02179744
10positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.92789563
11ionotropic glutamate receptor signaling pathway (GO:0035235)5.79866594
12glutamate receptor signaling pathway (GO:0007215)5.74844367
13regulation of short-term neuronal synaptic plasticity (GO:0048172)5.60123977
14vocalization behavior (GO:0071625)5.49859664
15synaptic vesicle maturation (GO:0016188)5.42740556
16positive regulation of synapse maturation (GO:0090129)5.27586221
17neurotransmitter secretion (GO:0007269)5.24641498
18positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.16691830
19synaptic transmission, glutamatergic (GO:0035249)5.16358126
20* cell differentiation in hindbrain (GO:0021533)5.08771255
21postsynaptic membrane organization (GO:0001941)5.04359401
22gamma-aminobutyric acid signaling pathway (GO:0007214)4.88841952
23neuromuscular process controlling posture (GO:0050884)4.87417206
24positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.77563906
25regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.77285612
26regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.74724086
27synaptic vesicle exocytosis (GO:0016079)4.68684903
28cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.65145214
29regulation of synaptic vesicle exocytosis (GO:2000300)4.64601375
30long-term memory (GO:0007616)4.53655737
31neuron-neuron synaptic transmission (GO:0007270)4.47624096
32layer formation in cerebral cortex (GO:0021819)4.39398434
33glutamate secretion (GO:0014047)4.39300798
34C4-dicarboxylate transport (GO:0015740)4.28885777
35potassium ion import (GO:0010107)4.26742475
36exploration behavior (GO:0035640)4.23663790
37gonadal mesoderm development (GO:0007506)4.18928931
38neurotransmitter transport (GO:0006836)4.14346752
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.13153299
40cell communication by electrical coupling (GO:0010644)4.10782301
41presynaptic membrane organization (GO:0097090)4.09844945
42transmission of nerve impulse (GO:0019226)4.05639492
43neuronal ion channel clustering (GO:0045161)4.04175502
44regulation of synapse maturation (GO:0090128)4.01402498
45neuromuscular process controlling balance (GO:0050885)4.00832691
46regulation of synaptic vesicle transport (GO:1902803)4.00061397
47adult walking behavior (GO:0007628)3.97785178
48regulation of neurotransmitter levels (GO:0001505)3.95381814
49positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.94932999
50presynaptic membrane assembly (GO:0097105)3.94740719
51establishment of nucleus localization (GO:0040023)3.90584984
52potassium ion homeostasis (GO:0055075)3.90453239
53membrane depolarization during action potential (GO:0086010)3.86781994
54cellular sodium ion homeostasis (GO:0006883)3.85959577
55regulation of glutamate receptor signaling pathway (GO:1900449)3.84861992
56regulation of excitatory postsynaptic membrane potential (GO:0060079)3.83217321
57positive regulation of potassium ion transmembrane transport (GO:1901381)3.74256311
58establishment of mitochondrion localization (GO:0051654)3.74213240
59cell migration in hindbrain (GO:0021535)3.72898742
60axon ensheathment in central nervous system (GO:0032291)3.69528219
61central nervous system myelination (GO:0022010)3.69528219
62dendrite morphogenesis (GO:0048813)3.67784910
63response to auditory stimulus (GO:0010996)3.66872262
64regulation of postsynaptic membrane potential (GO:0060078)3.64256431
65musculoskeletal movement (GO:0050881)3.63396112
66multicellular organismal movement (GO:0050879)3.63396112
67negative regulation of hormone metabolic process (GO:0032351)3.60506162
68negative regulation of hormone biosynthetic process (GO:0032353)3.60506162
69regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.59189870
70synaptic vesicle endocytosis (GO:0048488)3.58589565
71glycine transport (GO:0015816)3.58421102
72regulation of long-term neuronal synaptic plasticity (GO:0048169)3.58402241
73neuron cell-cell adhesion (GO:0007158)3.54918548
74synaptic vesicle docking involved in exocytosis (GO:0016081)3.52633505
75neurotransmitter-gated ion channel clustering (GO:0072578)3.52443595
76positive regulation of dendritic spine development (GO:0060999)3.52096391
77negative regulation of synaptic transmission, GABAergic (GO:0032229)3.51010073
78mating behavior (GO:0007617)3.49096965
79negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.48896124
80regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.48756350
81membrane depolarization (GO:0051899)3.47735321
82positive regulation of membrane potential (GO:0045838)3.46179573
83regulation of neurotransmitter secretion (GO:0046928)3.43268941
84prepulse inhibition (GO:0060134)3.42471958
85membrane hyperpolarization (GO:0060081)3.42309853
86negative regulation of microtubule polymerization (GO:0031115)3.37377968
87auditory behavior (GO:0031223)3.36718678
88regulation of voltage-gated calcium channel activity (GO:1901385)3.31490339
89dendritic spine morphogenesis (GO:0060997)3.31095465
90acidic amino acid transport (GO:0015800)3.31045496
91protein localization to synapse (GO:0035418)3.29727679
92neuron recognition (GO:0008038)3.26137526
93synapse assembly (GO:0007416)3.25955198
94long term synaptic depression (GO:0060292)3.24557979
95cell communication involved in cardiac conduction (GO:0086065)3.23789863
96positive regulation of dendritic spine morphogenesis (GO:0061003)3.23202786
97L-glutamate transport (GO:0015813)3.21906461
98activation of protein kinase A activity (GO:0034199)3.20674321
99mechanosensory behavior (GO:0007638)3.19725861
100membrane repolarization (GO:0086009)3.19453064
101neuron remodeling (GO:0016322)3.18771755
102regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.18515131
103regulation of synapse structural plasticity (GO:0051823)3.17311540
104neuromuscular process (GO:0050905)3.17003411
105regulation of calcium ion-dependent exocytosis (GO:0017158)3.16655009
106regulation of neuronal synaptic plasticity (GO:0048168)3.15918682
107regulation of synaptic plasticity (GO:0048167)3.14239213
108regulation of synaptic transmission, glutamatergic (GO:0051966)3.14067671
109positive regulation of neurotransmitter transport (GO:0051590)3.13439764
110L-amino acid import (GO:0043092)3.12640963
111regulation of neurotransmitter transport (GO:0051588)3.11921455
112cerebellar Purkinje cell layer development (GO:0021680)3.10258887
113proline transport (GO:0015824)3.09450200
114regulation of ARF protein signal transduction (GO:0032012)3.08497271
115detection of temperature stimulus involved in sensory perception (GO:0050961)3.07432609
116detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.07432609
117axonal fasciculation (GO:0007413)3.05406763
118positive regulation of potassium ion transport (GO:0043268)3.03233641
119neuromuscular synaptic transmission (GO:0007274)3.01919652
120regulation of vesicle fusion (GO:0031338)3.01556046
121dendritic spine organization (GO:0097061)2.97665879
122mitochondrion transport along microtubule (GO:0047497)2.93559326
123establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.93559326
124* synaptic transmission (GO:0007268)2.92616920
125intraspecies interaction between organisms (GO:0051703)2.91625004

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.85713924
2* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.45444415
3IKZF1_21737484_ChIP-ChIP_HCT116_Human3.42372719
4DROSHA_22980978_ChIP-Seq_HELA_Human3.09508634
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98512187
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.97878217
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.97878217
8* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94789234
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.84352266
10* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.68837927
11MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.68377441
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.61896900
13* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.60048900
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59161440
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54030322
16* EZH2_27294783_Chip-Seq_ESCs_Mouse2.50801757
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.49779788
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.45811047
19* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41226954
20GBX2_23144817_ChIP-Seq_PC3_Human2.34016341
21* REST_18959480_ChIP-ChIP_MESCs_Mouse2.33732594
22* RNF2_27304074_Chip-Seq_ESCs_Mouse2.23246117
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22006499
24* EZH2_27304074_Chip-Seq_ESCs_Mouse2.12684581
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.12499723
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.12124604
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.07568691
28ZNF274_21170338_ChIP-Seq_K562_Hela2.02765067
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.98225215
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.93676141
31* ERG_21242973_ChIP-ChIP_JURKAT_Human1.78614077
32THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67638395
33KDM2B_26808549_Chip-Seq_K562_Human1.60578503
34RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57935649
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53324524
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.51344140
37SMAD4_21799915_ChIP-Seq_A2780_Human1.45779804
38RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.42945376
39AR_19668381_ChIP-Seq_PC3_Human1.41778680
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37756950
41GATA1_26923725_Chip-Seq_HPCs_Mouse1.35853728
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.32717921
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.31167825
44GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30636616
45* RING1B_27294783_Chip-Seq_ESCs_Mouse1.28333196
46AR_21572438_ChIP-Seq_LNCaP_Human1.27166545
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26549924
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.26098732
49* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24610779
50WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21474240
51RING1B_27294783_Chip-Seq_NPCs_Mouse1.18229429
52TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.18051636
53SOX2_21211035_ChIP-Seq_LN229_Gbm1.16209165
54ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15553333
55TP53_16413492_ChIP-PET_HCT116_Human1.15129178
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.13666867
57RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13575249
58STAT3_23295773_ChIP-Seq_U87_Human1.12086616
59ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10625211
60WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10023740
61* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09901005
62SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09638669
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09023121
64CTCF_27219007_Chip-Seq_Bcells_Human1.07958236
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.07803344
66TET1_21490601_ChIP-Seq_MESCs_Mouse1.07479012
67AR_25329375_ChIP-Seq_VCAP_Human1.05473268
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05204601
69TAF15_26573619_Chip-Seq_HEK293_Human1.04338913
70TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03185016
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01355316
72CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99951653
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98527941
74CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98030053
75DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.96790636
76* SMAD3_21741376_ChIP-Seq_ESCs_Human0.96516908
77* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96002350
78EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95563366
79* TCF4_23295773_ChIP-Seq_U87_Human0.94743623
80CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94643561
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94140148
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93757449
83TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93757449
84* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.92868730
85SMAD4_21741376_ChIP-Seq_EPCs_Human0.92782668
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91764714
87* BMI1_23680149_ChIP-Seq_NPCS_Mouse0.91756070
88KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91630945
89OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91549533
90* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91244049
91CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89800957
92* CBX2_27304074_Chip-Seq_ESCs_Mouse0.89486955
93* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.88711529
94SMAD3_21741376_ChIP-Seq_EPCs_Human0.88371229
95KDM2B_26808549_Chip-Seq_JURKAT_Human0.88281322
96TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88243073
97ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88000573
98* SMAD4_21741376_ChIP-Seq_HESCs_Human0.87790479
99PIAS1_25552417_ChIP-Seq_VCAP_Human0.86893583
100TBX3_20139965_ChIP-Seq_MESCs_Mouse0.86701037
101TBX3_20139965_ChIP-Seq_ESCs_Mouse0.86419419
102SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.86160165
103* TP53_20018659_ChIP-ChIP_R1E_Mouse0.86064599
104SMAD_19615063_ChIP-ChIP_OVARY_Human0.85998094
105ARNT_22903824_ChIP-Seq_MCF-7_Human0.85929362
106RUNX2_22187159_ChIP-Seq_PCA_Human0.85667121
107RNF2_27304074_Chip-Seq_NSC_Mouse0.84668686
108RXR_22108803_ChIP-Seq_LS180_Human0.84076570
109DPY_21335234_ChIP-Seq_ESCs_Mouse0.82053847
110IGF1R_20145208_ChIP-Seq_DFB_Human0.79716131
111P53_22127205_ChIP-Seq_FIBROBLAST_Human0.79622117
112OCT4_19829295_ChIP-Seq_ESCs_Human0.79611126
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79376231
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79148310
115SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.78760612
116OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78643321
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78583237
118SOX9_26525672_Chip-Seq_HEART_Mouse0.78561594
119AHR_22903824_ChIP-Seq_MCF-7_Human0.78197270
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77696829
121RUNX1_26923725_Chip-Seq_HPCs_Mouse0.75982798

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009046_muscle_twitch5.49649897
2MP0004859_abnormal_synaptic_plasticity5.45919578
3* MP0003635_abnormal_synaptic_transmissio4.08719457
4MP0008569_lethality_at_weaning3.75307448
5MP0004145_abnormal_muscle_electrophysio3.34947739
6MP0002064_seizures3.26598413
7MP0009745_abnormal_behavioral_response3.25186715
8MP0002272_abnormal_nervous_system3.23237514
9MP0005423_abnormal_somatic_nervous3.14157435
10MP0003880_abnormal_central_pattern2.93834356
11MP0004270_analgesia2.87832666
12MP0001968_abnormal_touch/_nociception2.83746034
13MP0002063_abnormal_learning/memory/cond2.83264174
14MP0002067_abnormal_sensory_capabilities2.81663694
15MP0002734_abnormal_mechanical_nocicepti2.81498460
16MP0001440_abnormal_grooming_behavior2.79736171
17MP0002572_abnormal_emotion/affect_behav2.71160399
18MP0001501_abnormal_sleep_pattern2.39243903
19MP0002736_abnormal_nociception_after2.38623601
20* MP0002184_abnormal_innervation2.35553107
21MP0001486_abnormal_startle_reflex2.24827651
22MP0003123_paternal_imprinting2.23575506
23MP0004142_abnormal_muscle_tone2.18711133
24MP0002735_abnormal_chemical_nociception2.13993872
25MP0002733_abnormal_thermal_nociception2.05071298
26MP0004885_abnormal_endolymph1.96094288
27MP0005386_behavior/neurological_phenoty1.91011160
28MP0004924_abnormal_behavior1.91011160
29MP0001970_abnormal_pain_threshold1.89072205
30MP0003329_amyloid_beta_deposits1.88584007
31MP0002557_abnormal_social/conspecific_i1.86961027
32MP0000566_synostosis1.84955878
33MP0004742_abnormal_vestibular_system1.84834781
34MP0004147_increased_porphyrin_level1.75990979
35MP0000955_abnormal_spinal_cord1.73133827
36* MP0002066_abnormal_motor_capabilities/c1.63457133
37MP0000778_abnormal_nervous_system1.61686861
38MP0002822_catalepsy1.51528444
39MP0004811_abnormal_neuron_physiology1.46507699
40MP0003121_genomic_imprinting1.46205761
41MP0002909_abnormal_adrenal_gland1.43871236
42MP0004858_abnormal_nervous_system1.43680259
43MP0003633_abnormal_nervous_system1.42606361
44MP0006292_abnormal_olfactory_placode1.40112029
45MP0005646_abnormal_pituitary_gland1.36575465
46* MP0003632_abnormal_nervous_system1.35563527
47* MP0002882_abnormal_neuron_morphology1.33696565
48MP0001502_abnormal_circadian_rhythm1.27648930
49MP0003879_abnormal_hair_cell1.27263652
50MP0005409_darkened_coat_color1.26321815
51* MP0002152_abnormal_brain_morphology1.23824761
52* MP0003631_nervous_system_phenotype1.23451143
53MP0003690_abnormal_glial_cell1.22705532
54MP0008872_abnormal_physiological_respon1.21659878
55MP0001905_abnormal_dopamine_level1.20048981
56MP0000920_abnormal_myelination1.19308863
57MP0006276_abnormal_autonomic_nervous1.19023586
58MP0000569_abnormal_digit_pigmentation1.17160305
59MP0001984_abnormal_olfaction1.17101277
60MP0005083_abnormal_biliary_tract1.15016609
61MP0008877_abnormal_DNA_methylation1.10834697
62MP0004215_abnormal_myocardial_fiber1.09555836
63MP0000579_abnormal_nail_morphology1.09250423
64MP0003283_abnormal_digestive_organ1.04646173
65MP0002089_abnormal_postnatal_growth/wei1.04538728
66MP0002229_neurodegeneration1.03913672
67MP0003122_maternal_imprinting1.03175778
68MP0003137_abnormal_impulse_conducting1.02290363
69MP0001299_abnormal_eye_distance/1.01234313
70MP0004043_abnormal_pH_regulation1.01056373
71MP0001346_abnormal_lacrimal_gland0.96705143
72MP0000751_myopathy0.92027628
73MP0005187_abnormal_penis_morphology0.91573072
74MP0006072_abnormal_retinal_apoptosis0.90870307
75MP0001348_abnormal_lacrimal_gland0.90435061
76MP0000631_abnormal_neuroendocrine_gland0.88035563
77MP0003045_fibrosis0.85732802
78MP0001529_abnormal_vocalization0.85296195
79MP0003938_abnormal_ear_development0.85157280
80MP0002638_abnormal_pupillary_reflex0.84257749
81MP0005645_abnormal_hypothalamus_physiol0.83852224
82MP0000013_abnormal_adipose_tissue0.83605629
83MP0000604_amyloidosis0.83441219
84MP0003787_abnormal_imprinting0.82477759
85MP0002069_abnormal_eating/drinking_beha0.82061812
86MP0003634_abnormal_glial_cell0.80489196
87MP0009780_abnormal_chondrocyte_physiolo0.80357475
88MP0000026_abnormal_inner_ear0.79092711
89MP0005623_abnormal_meninges_morphology0.78312177
90MP0004484_altered_response_of0.77285708
91MP0009379_abnormal_foot_pigmentation0.76304857
92MP0002249_abnormal_larynx_morphology0.76210091
93MP0005551_abnormal_eye_electrophysiolog0.75850871
94MP0001485_abnormal_pinna_reflex0.75656829
95MP0004510_myositis0.75533735
96MP0001963_abnormal_hearing_physiology0.75299066
97MP0010769_abnormal_survival0.75008297
98MP0004233_abnormal_muscle_weight0.73882862
99MP0002752_abnormal_somatic_nervous0.72145571
100MP0010768_mortality/aging0.71649714
101MP0004085_abnormal_heartbeat0.71423754
102MP0000537_abnormal_urethra_morphology0.70893327
103MP0008874_decreased_physiological_sensi0.70634860
104MP0000747_muscle_weakness0.70244906
105MP0002082_postnatal_lethality0.69238674
106MP0010770_preweaning_lethality0.69238674
107MP0001177_atelectasis0.67141069
108MP0003861_abnormal_nervous_system0.66434090
109MP0003119_abnormal_digestive_system0.63063308
110MP0001986_abnormal_taste_sensitivity0.61895195
111MP0005535_abnormal_body_temperature0.60900750
112MP0001188_hyperpigmentation0.60887030
113MP0005499_abnormal_olfactory_system0.60232603
114MP0005394_taste/olfaction_phenotype0.60232603
115MP0002234_abnormal_pharynx_morphology0.60196444
116MP0005167_abnormal_blood-brain_barrier0.57581046
117MP0001943_abnormal_respiration0.56590957
118MP0003646_muscle_fatigue0.56588096
119MP0010030_abnormal_orbit_morphology0.56369601
120MP0000639_abnormal_adrenal_gland0.55645783
121MP0003956_abnormal_body_size0.54846863
122MP0008961_abnormal_basal_metabolism0.52088121
123MP0003866_abnormal_defecation0.45520707

Predicted human phenotypes

RankGene SetZ-score
1Action tremor (HP:0002345)7.64984446
2Progressive cerebellar ataxia (HP:0002073)7.61678815
3Visual hallucinations (HP:0002367)6.35793084
4Gaze-evoked nystagmus (HP:0000640)5.81046865
5Focal motor seizures (HP:0011153)5.72507283
6Focal seizures (HP:0007359)5.27037754
7Scanning speech (HP:0002168)5.15092367
8Dysmetric saccades (HP:0000641)5.04567202
9Myokymia (HP:0002411)4.99399376
10Atonic seizures (HP:0010819)4.94064144
11Impaired smooth pursuit (HP:0007772)4.85121626
12Dysdiadochokinesis (HP:0002075)4.83314801
13Hemiplegia (HP:0002301)4.74650620
14Abnormality of ocular smooth pursuit (HP:0000617)4.58054435
15Genetic anticipation (HP:0003743)4.46587301
16Febrile seizures (HP:0002373)4.43382633
17Intention tremor (HP:0002080)4.42825205
18Broad-based gait (HP:0002136)4.26302670
19Absence seizures (HP:0002121)4.03198214
20Diplopia (HP:0000651)4.01991629
21Abnormality of binocular vision (HP:0011514)4.01991629
22Dysmetria (HP:0001310)3.99317406
23Tetraplegia (HP:0002445)3.94041238
24Hemiparesis (HP:0001269)3.89527426
25Abnormality of the lower motor neuron (HP:0002366)3.81094783
26Truncal ataxia (HP:0002078)3.80538010
27Epileptic encephalopathy (HP:0200134)3.68110604
28Postural tremor (HP:0002174)3.60929245
29Torticollis (HP:0000473)3.55051371
30Cerebral hypomyelination (HP:0006808)3.42706271
31Dialeptic seizures (HP:0011146)3.38542413
32Status epilepticus (HP:0002133)3.36981102
33Horizontal nystagmus (HP:0000666)3.29613980
34Poor eye contact (HP:0000817)3.28568630
35Obstructive sleep apnea (HP:0002870)3.27549184
36Generalized tonic-clonic seizures (HP:0002069)3.27463979
37Annular pancreas (HP:0001734)3.21401570
38Agitation (HP:0000713)3.13475986
39Ventricular fibrillation (HP:0001663)3.13442421
40Abnormality of saccadic eye movements (HP:0000570)3.09648712
41Limb ataxia (HP:0002070)3.03163505
42Abnormal social behavior (HP:0012433)3.02595628
43Impaired social interactions (HP:0000735)3.02595628
44Amyotrophic lateral sclerosis (HP:0007354)3.01517955
45Sleep apnea (HP:0010535)3.00102865
46Depression (HP:0000716)2.95549436
47Focal dystonia (HP:0004373)2.95336799
48Cerebral inclusion bodies (HP:0100314)2.94204392
49Supranuclear gaze palsy (HP:0000605)2.84028805
50Abnormal eating behavior (HP:0100738)2.78152739
51Oligodactyly (hands) (HP:0001180)2.77996420
52Anxiety (HP:0000739)2.75479052
53Mutism (HP:0002300)2.73344478
54Papilledema (HP:0001085)2.71843294
55Abnormality of the corticospinal tract (HP:0002492)2.69418560
56Lower limb asymmetry (HP:0100559)2.68519183
57Craniofacial dystonia (HP:0012179)2.65748207
58Gait ataxia (HP:0002066)2.60965602
59Morphological abnormality of the pyramidal tract (HP:0002062)2.59817407
60Akinesia (HP:0002304)2.50911089
61Myotonia (HP:0002486)2.47332395
62Postural instability (HP:0002172)2.36827275
63Aplasia involving bones of the upper limbs (HP:0009823)2.36251826
64Aplasia of the phalanges of the hand (HP:0009802)2.36251826
65Aplasia involving bones of the extremities (HP:0009825)2.36251826
66Neuronal loss in central nervous system (HP:0002529)2.35770336
67Bundle branch block (HP:0011710)2.33167718
68Pointed chin (HP:0000307)2.30652071
69Stereotypic behavior (HP:0000733)2.25772192
70Psychosis (HP:0000709)2.21589978
71Polyphagia (HP:0002591)2.20792124
72Spinal canal stenosis (HP:0003416)2.19395410
73Spastic gait (HP:0002064)2.18226224
74Lower limb muscle weakness (HP:0007340)2.15733890
75Impaired vibration sensation in the lower limbs (HP:0002166)2.13512426
76Hand muscle atrophy (HP:0009130)2.11946665
77CNS hypomyelination (HP:0003429)2.09350242
78Slow progression (HP:0003677)2.08681943
79Excessive salivation (HP:0003781)2.06515058
80Drooling (HP:0002307)2.06515058
81Turricephaly (HP:0000262)2.03124618
82Choreoathetosis (HP:0001266)2.03030224
83Confusion (HP:0001289)2.02590357
84Shallow orbits (HP:0000586)1.96929217
85Urinary urgency (HP:0000012)1.95252003
86Abnormal hair whorl (HP:0010721)1.95022956
87Pheochromocytoma (HP:0002666)1.93734815
88Split foot (HP:0001839)1.93202848
89Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.92757397
90Degeneration of the lateral corticospinal tracts (HP:0002314)1.92757397
91Incomplete penetrance (HP:0003829)1.92037980
92Fetal akinesia sequence (HP:0001989)1.91364239
93Hypoplastic nipples (HP:0002557)1.90750752
94Ankle clonus (HP:0011448)1.90398567
95Neoplasm of the heart (HP:0100544)1.90016272
96Rigidity (HP:0002063)1.89828555
97Broad metatarsal (HP:0001783)1.89131776
98Impaired vibratory sensation (HP:0002495)1.87154723
99Aqueductal stenosis (HP:0002410)1.86419215
100Rapidly progressive (HP:0003678)1.85345640
101Oligodactyly (HP:0012165)1.85188636
102Urinary bladder sphincter dysfunction (HP:0002839)1.84198591
103Peripheral hypomyelination (HP:0007182)1.83964462
104Clonus (HP:0002169)1.81878835
105Spastic tetraplegia (HP:0002510)1.81285807
106Delusions (HP:0000746)1.80444982
107Narrow nasal bridge (HP:0000446)1.79562315
108Spastic tetraparesis (HP:0001285)1.78013079
109Bronchomalacia (HP:0002780)1.77762035
110Limb dystonia (HP:0002451)1.77317876
111Unsteady gait (HP:0002317)1.75969671
112EEG with generalized epileptiform discharges (HP:0011198)1.75606893
113Apathy (HP:0000741)1.75385377
114Progressive inability to walk (HP:0002505)1.73231637
115Epileptiform EEG discharges (HP:0011182)1.72295872
116Bradykinesia (HP:0002067)1.71694395
117Restlessness (HP:0000711)1.68965526
118Hypsarrhythmia (HP:0002521)1.68776119
119Insomnia (HP:0100785)1.67243121
120Neurofibrillary tangles (HP:0002185)1.66583735
121Absent speech (HP:0001344)1.62781221
122Megalencephaly (HP:0001355)1.62014904
123Distal upper limb amyotrophy (HP:0007149)1.61950200
124Upper limb amyotrophy (HP:0009129)1.61950200
125Amblyopia (HP:0000646)1.60797663
126Hyperventilation (HP:0002883)1.59610905
127Failure to thrive in infancy (HP:0001531)1.57488089
128Dysarthria (HP:0001260)1.57214591
129Achilles tendon contracture (HP:0001771)1.56790012
130Cerebellar atrophy (HP:0001272)1.56589671

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMKK24.53048855
2RIPK13.86141722
3NTRK33.65863144
4EPHA43.14381502
5MAP3K93.05210513
6MAP3K42.94098343
7WNK12.78689318
8CAMKK12.73422553
9NTRK22.54980022
10MINK12.53938283
11MARK12.48740792
12CDK192.41827876
13MAP2K42.31878586
14PAK62.30708563
15STK382.29574215
16PNCK2.11923843
17MAP2K71.94464686
18DAPK21.84663270
19PRPF4B1.55688045
20FGFR21.55171774
21TYRO31.53115791
22RIPK41.51985415
23PRKCG1.46431831
24ALK1.33148077
25SIK21.30413089
26UHMK11.30102405
27TNIK1.28468670
28STK111.24114300
29GRK51.22482481
30OXSR11.21260095
31SGK2231.21022738
32SGK4941.21022738
33SGK21.20499578
34CAMK1G1.19121511
35CDK51.19000341
36PRKCH1.17513208
37CAMK11.14630951
38MAPKAPK51.13418799
39SGK31.12825894
40NTRK11.11812942
41MAPK131.11810590
42CDK151.11114264
43CAMK41.07025575
44CDK181.06605728
45PINK11.05883654
46MAP3K121.04472121
47CAMK2G1.00952121
48ARAF1.00820209
49PHKG21.00546897
50PHKG11.00546897
51CDK11A0.98397971
52PTK60.96218051
53KSR20.93313617
54CDK140.92792851
55KSR10.92541004
56CDC42BPA0.87983199
57CAMK2B0.86032763
58RET0.85533214
59DYRK20.85527930
60PKN10.85489558
61DYRK1A0.84617861
62PLK20.81413004
63CAMK2A0.78578674
64PTK20.75292591
65CAMK2D0.74363639
66ROCK20.73860633
67SGK10.65541180
68BRSK10.64904003
69EPHB10.64899369
70PRKG10.63470801
71PDK10.63286702
72RPS6KA30.62506182
73MARK20.57779258
74HIPK20.56458910
75LATS20.56347918
76DAPK10.56320005
77FYN0.55937266
78RPS6KA20.55743739
79CASK0.53045263
80PDPK10.52497133
81LMTK20.51959858
82SCYL20.51917096
83PRKDC0.49779362
84CSNK1G20.46436882
85PRKD30.45937983
86ICK0.44616814
87ERBB30.43485182
88PAK30.42993939
89MAPK100.42932777
90NEK60.42855094
91PRKACA0.42083815
92LIMK10.40954469
93BRAF0.40660800
94MAP3K130.40460679
95FES0.40419588
96CSNK1E0.39888630
97SRC0.39699945
98PRKACB0.39623484
99PRKAA10.38020545
100MAPK80.37587374
101EPHB20.37338207
102ERBB20.36115601
103MAPK120.35484329
104MAPK90.35279655
105RPS6KB10.35158711
106PRKCB0.33221273
107PRKCZ0.32967524
108PRKACG0.32280186
109PRKCA0.32080298
110DAPK30.31154476
111TNK20.31135305
112GSK3B0.30525074
113BMX0.30060335
114CSNK1D0.27787973
115CAMK1D0.27543505
116DMPK0.26058499
117EEF2K0.24544617

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.81671423
2Glutamatergic synapse_Homo sapiens_hsa047243.21960463
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.03637896
4Long-term potentiation_Homo sapiens_hsa047203.03145464
5Synaptic vesicle cycle_Homo sapiens_hsa047212.91330742
6GABAergic synapse_Homo sapiens_hsa047272.81090013
7Long-term depression_Homo sapiens_hsa047302.79181346
8Circadian entrainment_Homo sapiens_hsa047132.70910985
9Taste transduction_Homo sapiens_hsa047422.57686966
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.41970670
11Morphine addiction_Homo sapiens_hsa050322.39771026
12Salivary secretion_Homo sapiens_hsa049702.31679937
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.28967668
14Amphetamine addiction_Homo sapiens_hsa050312.17385032
15Gastric acid secretion_Homo sapiens_hsa049711.95665372
16Aldosterone synthesis and secretion_Homo sapiens_hsa049251.90654829
17Dopaminergic synapse_Homo sapiens_hsa047281.87830366
18Insulin secretion_Homo sapiens_hsa049111.75595269
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.64901208
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.61545106
21Type II diabetes mellitus_Homo sapiens_hsa049301.60738960
22Cholinergic synapse_Homo sapiens_hsa047251.60077677
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.59123122
24Olfactory transduction_Homo sapiens_hsa047401.57668387
25Phosphatidylinositol signaling system_Homo sapiens_hsa040701.57030043
26Calcium signaling pathway_Homo sapiens_hsa040201.47965801
27Oxytocin signaling pathway_Homo sapiens_hsa049211.47001805
28Pancreatic secretion_Homo sapiens_hsa049721.36522786
29Serotonergic synapse_Homo sapiens_hsa047261.33559224
30Estrogen signaling pathway_Homo sapiens_hsa049151.32784196
31GnRH signaling pathway_Homo sapiens_hsa049121.30744067
32cAMP signaling pathway_Homo sapiens_hsa040241.29829675
33Renin secretion_Homo sapiens_hsa049241.29285468
34Gap junction_Homo sapiens_hsa045401.27463301
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23333583
36Thyroid hormone synthesis_Homo sapiens_hsa049181.22271600
37Cardiac muscle contraction_Homo sapiens_hsa042601.19620020
38Cocaine addiction_Homo sapiens_hsa050301.17487499
39Nitrogen metabolism_Homo sapiens_hsa009101.06711805
40Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06156559
41Phototransduction_Homo sapiens_hsa047441.03607128
42cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01948712
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01640308
44Bile secretion_Homo sapiens_hsa049760.96964434
45Phospholipase D signaling pathway_Homo sapiens_hsa040720.95172235
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.92968935
47Inositol phosphate metabolism_Homo sapiens_hsa005620.89093170
48Oocyte meiosis_Homo sapiens_hsa041140.88248676
49Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82050516
50Melanogenesis_Homo sapiens_hsa049160.79755301
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.77865960
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.74563471
53Dilated cardiomyopathy_Homo sapiens_hsa054140.74294157
54Phenylalanine metabolism_Homo sapiens_hsa003600.74042459
55Collecting duct acid secretion_Homo sapiens_hsa049660.70225934
56Prion diseases_Homo sapiens_hsa050200.69841839
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68177703
58Axon guidance_Homo sapiens_hsa043600.66346173
59Ras signaling pathway_Homo sapiens_hsa040140.65645441
60ErbB signaling pathway_Homo sapiens_hsa040120.65395493
61Choline metabolism in cancer_Homo sapiens_hsa052310.65016179
62Dorso-ventral axis formation_Homo sapiens_hsa043200.64129838
63MAPK signaling pathway_Homo sapiens_hsa040100.63476328
64Glioma_Homo sapiens_hsa052140.63329682
65Circadian rhythm_Homo sapiens_hsa047100.58271871
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57736552
67Hippo signaling pathway_Homo sapiens_hsa043900.57117956
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54663237
69mTOR signaling pathway_Homo sapiens_hsa041500.54100188
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.53810022
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52994934
72Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51606729
73Vitamin B6 metabolism_Homo sapiens_hsa007500.50552278
74Arginine and proline metabolism_Homo sapiens_hsa003300.50036073
75Mineral absorption_Homo sapiens_hsa049780.48682831
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46553961
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46043783
78beta-Alanine metabolism_Homo sapiens_hsa004100.45772538
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44144404
80VEGF signaling pathway_Homo sapiens_hsa043700.43331078
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41902737
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41045747
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.39929589
84Glucagon signaling pathway_Homo sapiens_hsa049220.37612868
85Protein digestion and absorption_Homo sapiens_hsa049740.36615318
86Hedgehog signaling pathway_Homo sapiens_hsa043400.35728628
87Histidine metabolism_Homo sapiens_hsa003400.34955155
88Ovarian steroidogenesis_Homo sapiens_hsa049130.34755785
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33259248
90Rap1 signaling pathway_Homo sapiens_hsa040150.32295528
91Proteoglycans in cancer_Homo sapiens_hsa052050.32273487
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31161482
93AMPK signaling pathway_Homo sapiens_hsa041520.31022539
94Endocytosis_Homo sapiens_hsa041440.30801856
95Alcoholism_Homo sapiens_hsa050340.29825783
96Arginine biosynthesis_Homo sapiens_hsa002200.29344576
97Alzheimers disease_Homo sapiens_hsa050100.29194160
98Endometrial cancer_Homo sapiens_hsa052130.28916078
99Fatty acid biosynthesis_Homo sapiens_hsa000610.28748786
100Basal cell carcinoma_Homo sapiens_hsa052170.27766082
101Tight junction_Homo sapiens_hsa045300.27309568
102Platelet activation_Homo sapiens_hsa046110.25411369
103Wnt signaling pathway_Homo sapiens_hsa043100.25340638
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.24537696
105Chemokine signaling pathway_Homo sapiens_hsa040620.24528202
106Vibrio cholerae infection_Homo sapiens_hsa051100.23808924
107Renal cell carcinoma_Homo sapiens_hsa052110.23083947
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.21294050
109Non-small cell lung cancer_Homo sapiens_hsa052230.21204326
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.20652799
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20363488
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.19636331
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.18968850
114Parkinsons disease_Homo sapiens_hsa050120.18887778
115Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.18070186

Most similar genes based on co-expression Upload to Enrichr

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