CBL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.72097845
2positive T cell selection (GO:0043368)5.25041137
3regulation of gamma-delta T cell differentiation (GO:0045586)5.23713312
4activated T cell proliferation (GO:0050798)5.23638855
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.03260279
6negative regulation of cell killing (GO:0031342)5.03260279
7V(D)J recombination (GO:0033151)5.01539260
8negative T cell selection (GO:0043383)4.93514464
9regulation of gamma-delta T cell activation (GO:0046643)4.89313318
10T cell selection (GO:0045058)4.58396150
11negative regulation of thymocyte apoptotic process (GO:0070244)4.54243202
12positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.09865573
13positive thymic T cell selection (GO:0045059)4.06499176
14interferon-gamma production (GO:0032609)3.96257964
15detection of molecule of bacterial origin (GO:0032490)3.95429897
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.95222462
17negative thymic T cell selection (GO:0045060)3.90197303
18positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.85350337
19detection of other organism (GO:0098543)3.79100737
20response to peptidoglycan (GO:0032494)3.78292835
21antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.76256557
22regulation of B cell receptor signaling pathway (GO:0050855)3.70497447
23neutrophil activation involved in immune response (GO:0002283)3.60145972
24thymic T cell selection (GO:0045061)3.51315609
25leukocyte aggregation (GO:0070486)3.48320219
26negative regulation of translation, ncRNA-mediated (GO:0040033)3.47376001
27regulation of translation, ncRNA-mediated (GO:0045974)3.47376001
28negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.47376001
29response to muramyl dipeptide (GO:0032495)3.45485593
30regulation of T cell tolerance induction (GO:0002664)3.45403466
31detection of external biotic stimulus (GO:0098581)3.43332613
32microglial cell activation (GO:0001774)3.43069818
33positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.39880254
34T cell receptor signaling pathway (GO:0050852)3.38812158
35response to host immune response (GO:0052572)3.38575933
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.38575933
37modulation by virus of host process (GO:0019054)3.37334733
38detection of bacterium (GO:0016045)3.35394353
39modulation by symbiont of host cellular process (GO:0044068)3.32694607
40negative regulation of T cell mediated immunity (GO:0002710)3.31950320
41mitotic sister chromatid cohesion (GO:0007064)3.31717308
42positive regulation by symbiont of host defense response (GO:0052509)3.31171988
43modulation by symbiont of host defense response (GO:0052031)3.31171988
44modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.31171988
45modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.31171988
46positive regulation by organism of defense response of other organism involved in symbiotic interact3.31171988
47modulation by symbiont of host immune response (GO:0052553)3.31171988
48response to host defenses (GO:0052200)3.28893772
49response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.28893772
50response to host (GO:0075136)3.28893772
51negative regulation of interleukin-12 production (GO:0032695)3.28307857
52cytoplasmic mRNA processing body assembly (GO:0033962)3.25261035
53regulation of thymocyte apoptotic process (GO:0070243)3.21374955
54positive regulation of B cell differentiation (GO:0045579)3.20938531
55histone H3-K4 trimethylation (GO:0080182)3.20674311
56antigen receptor-mediated signaling pathway (GO:0050851)3.20162654
57alpha-beta T cell differentiation (GO:0046632)3.18995736
58negative regulation of erythrocyte differentiation (GO:0045647)3.18550565
59positive regulation of interleukin-2 production (GO:0032743)3.18054203
60alpha-beta T cell activation (GO:0046631)3.17537882
61regulation of B cell differentiation (GO:0045577)3.16505175
62regulation of interferon-beta biosynthetic process (GO:0045357)3.15063787
63B cell receptor signaling pathway (GO:0050853)3.13630031
64T cell homeostasis (GO:0043029)3.12883659
65mast cell activation (GO:0045576)3.10546267
66detection of biotic stimulus (GO:0009595)3.07486751
67regulation of interleukin-2 biosynthetic process (GO:0045076)3.06616940
68tolerance induction (GO:0002507)3.06152923
69respiratory burst (GO:0045730)3.05943768
70regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.05903008
71negative regulation of lymphocyte mediated immunity (GO:0002707)3.03130943
72neutrophil mediated immunity (GO:0002446)3.02889872
73T cell costimulation (GO:0031295)3.01917594
74pre-miRNA processing (GO:0031054)3.00907093
75T cell differentiation (GO:0030217)2.95214499
76lymphocyte costimulation (GO:0031294)2.94767693
77regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.90510883
78positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.90510883
79macrophage activation (GO:0042116)2.88656026
80positive regulation of mast cell activation (GO:0033005)2.86898129
81T cell proliferation (GO:0042098)2.86290869
82lymphocyte homeostasis (GO:0002260)2.85421641
83leukocyte migration involved in inflammatory response (GO:0002523)2.85346499
84mast cell activation involved in immune response (GO:0002279)2.83516835
85mast cell degranulation (GO:0043303)2.83516835
86positive regulation of tolerance induction (GO:0002645)2.82419706
87phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.82110383
88response to interleukin-15 (GO:0070672)2.81642789
89positive regulation of histone deacetylation (GO:0031065)2.79418677
90regulation of leukocyte degranulation (GO:0043300)2.78173722
91regulation of tolerance induction (GO:0002643)2.77657100
92positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.77588786
93regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.77588786
94nuclear pore organization (GO:0006999)2.77363279
95negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.76974385
96regulation of mast cell degranulation (GO:0043304)2.76614536
97antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.74713672
98antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.74713672
99regulation of interleukin-12 biosynthetic process (GO:0045075)2.74695702
100regulation of T cell receptor signaling pathway (GO:0050856)2.73445301
101antigen processing and presentation of endogenous antigen (GO:0019883)2.72935160
102B cell homeostasis (GO:0001782)2.70646256
103negative regulation of leukocyte mediated immunity (GO:0002704)2.69612367
104germinal center formation (GO:0002467)2.69131554
105positive regulation of mRNA catabolic process (GO:0061014)2.68877094
106hypotonic response (GO:0006971)2.68065371
107negative regulation of histone methylation (GO:0031061)2.66976618
108histone lysine demethylation (GO:0070076)2.65282853
109regulation of myeloid leukocyte mediated immunity (GO:0002886)2.63831441
110antigen processing and presentation via MHC class Ib (GO:0002475)2.63522894
111cellular extravasation (GO:0045123)2.62534740
112myeloid leukocyte mediated immunity (GO:0002444)2.61480588
113histone H3-K4 methylation (GO:0051568)2.60240362
114CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.57587739
115negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.57164973
116regulation of histone H3-K9 methylation (GO:0051570)2.56799204
117nuclear pore complex assembly (GO:0051292)2.56715714
118immune response-activating cell surface receptor signaling pathway (GO:0002429)2.56259618
119regulation of mast cell activation involved in immune response (GO:0033006)2.56158272
120regulation of alpha-beta T cell proliferation (GO:0046640)2.55543340
121negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.54900402
122histone demethylation (GO:0016577)2.54484108
123positive regulation of granulocyte differentiation (GO:0030854)2.54137141
124myeloid cell activation involved in immune response (GO:0002275)2.53588762
125regulation of NFAT protein import into nucleus (GO:0051532)2.53415549
126neutrophil activation (GO:0042119)2.53400131
127production of molecular mediator involved in inflammatory response (GO:0002532)2.53010956
128mononuclear cell proliferation (GO:0032943)2.52008363
129macrophage activation involved in immune response (GO:0002281)2.51985538
130histone H3-K9 demethylation (GO:0033169)2.51619831
131NLS-bearing protein import into nucleus (GO:0006607)2.50054745
132lymphocyte proliferation (GO:0046651)2.49269869
133hepatocyte apoptotic process (GO:0097284)2.48798348
134negative regulation of DNA repair (GO:0045738)2.47034858
135negative regulation of B cell proliferation (GO:0030889)2.46808293
136genitalia morphogenesis (GO:0035112)2.45758624
137regulation of mRNA catabolic process (GO:0061013)2.45628540
138regulation of interleukin-2 production (GO:0032663)2.45465468
139histone H3-K36 demethylation (GO:0070544)2.45429735
140regulation of macrophage cytokine production (GO:0010935)2.44993292
141negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.44533838
142negative regulation of T-helper cell differentiation (GO:0045623)2.44533838
143pore complex assembly (GO:0046931)2.43969779
144regulation of mast cell activation (GO:0033003)2.43897292
145granulocyte activation (GO:0036230)2.43613375
146B cell proliferation (GO:0042100)2.43598685
147regulation of RNA export from nucleus (GO:0046831)2.43199276
148megakaryocyte development (GO:0035855)2.43097106
149cellular response to interleukin-15 (GO:0071350)2.42524542
150negative regulation of T cell apoptotic process (GO:0070233)2.41252093
151Peyers patch development (GO:0048541)2.40425221
152mucosal-associated lymphoid tissue development (GO:0048537)2.40425221
153T cell migration (GO:0072678)2.39158769

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.70789880
2E2F7_22180533_ChIP-Seq_HELA_Human4.79823627
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.62309870
4* EGR1_19374776_ChIP-ChIP_THP-1_Human3.94516702
5MYC_22102868_ChIP-Seq_BL_Human3.31531409
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.21470903
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.19193068
8FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.14479173
9IRF8_22096565_ChIP-ChIP_GC-B_Human3.12515484
10* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.05455613
11RUNX_20019798_ChIP-Seq_JUKART_Human3.05449301
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.95994787
13* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.94032806
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.92450797
15* IRF8_21731497_ChIP-ChIP_J774_Mouse2.92414744
16* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.83334883
17MYB_26560356_Chip-Seq_TH2_Human2.76073417
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.67144149
19SCL_19346495_ChIP-Seq_HPC-7_Human2.61116271
20VDR_21846776_ChIP-Seq_THP-1_Human2.57117680
21* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54898284
22TCF7_22412390_ChIP-Seq_EML_Mouse2.54884647
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.48231338
24UTX_26944678_Chip-Seq_JUKART_Human2.31425880
25KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.27502897
26MYB_26560356_Chip-Seq_TH1_Human2.24513412
27* MAF_26560356_Chip-Seq_TH1_Human2.23290363
28IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.20632464
29VDR_24763502_ChIP-Seq_THP-1_Human2.18065131
30BRD4_27068464_Chip-Seq_AML-cells_Mouse2.06203346
31* KDM2B_26808549_Chip-Seq_DND41_Human2.01080144
32VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.00873812
33SPI1_23127762_ChIP-Seq_K562_Human1.98706123
34GATA3_27048872_Chip-Seq_THYMUS_Human1.93895509
35* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.92377374
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.89598244
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.88204861
38* RUNX1_22412390_ChIP-Seq_EML_Mouse1.86924433
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.84406826
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.82585860
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.82585860
42KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.82585860
43STAT4_19710469_ChIP-ChIP_TH1__Mouse1.80089706
44E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70628849
45KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67141627
46* SPI1_23547873_ChIP-Seq_NB4_Human1.59393931
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59246699
48PU_27001747_Chip-Seq_BMDM_Mouse1.55345658
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.47922011
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46251960
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.40763723
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.39590737
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.38025898
54NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.37166069
55VDR_24787735_ChIP-Seq_THP-1_Human1.36969244
56* KDM2B_26808549_Chip-Seq_JURKAT_Human1.30520002
57* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27022937
58MAF_26560356_Chip-Seq_TH2_Human1.24740043
59MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21406542
60PKCTHETA_26484144_Chip-Seq_BREAST_Human1.21231061
61GATA1_22025678_ChIP-Seq_K562_Human1.19180965
62CIITA_25753668_ChIP-Seq_RAJI_Human1.15964207
63RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.15033339
64SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.11665557
65FOXO3_23340844_ChIP-Seq_DLD1_Human1.08756686
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06947564
67* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05643248
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02161565
69GATA3_26560356_Chip-Seq_TH2_Human1.01960272
70PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01338640
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99722117
72GATA1_19941827_ChIP-Seq_MEL86_Mouse0.98722100
73DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93735125
74NOTCH1_21737748_ChIP-Seq_TLL_Human0.93000150
75TFEB_21752829_ChIP-Seq_HELA_Human0.92959396
76NCOR1_26117541_ChIP-Seq_K562_Human0.92663834
77ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92591074
78* ELK3_25401928_ChIP-Seq_HUVEC_Human0.91904227
79GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90251203
80TP63_19390658_ChIP-ChIP_HaCaT_Human0.88913758
81STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87489081
82* KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.86374491
83SALL1_21062744_ChIP-ChIP_HESCs_Human0.86176826
84SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.85506848
85RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.84795434
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83835779
87LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.83562289
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83546498
89SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.83069565
90CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82899784
91P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82636924
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82195298
93PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80586362
94* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.79980168
95GATA1_19941826_ChIP-Seq_K562_Human0.79766622
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79677608
97GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79669107
98GATA2_19941826_ChIP-Seq_K562_Human0.79659611
99NFIB_24661679_ChIP-Seq_LUNG_Mouse0.78921382
100CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78875672
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.77999696
102GATA1_19941827_ChIP-Seq_MEL_Mouse0.77864199
103* TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.77355866
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77073530
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.76761318
106ETS1_22383799_ChIP-Seq_G1ME_Mouse0.76564849
107ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.74820995
108FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.74674054
109KDM2B_26808549_Chip-Seq_K562_Human0.73823716
110SMRT_27268052_Chip-Seq_Bcells_Human0.73568194
111STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.73531030
112* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.73279476
113FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.71458280
114RUNX1_27514584_Chip-Seq_MCF-7_Human0.70682931
115* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.67612890
116E2F1_21310950_ChIP-Seq_MCF-7_Human0.67589591
117GATA1_22383799_ChIP-Seq_G1ME_Mouse0.66963988

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.44344293
2MP0001835_abnormal_antigen_presentation3.28966764
3MP0002166_altered_tumor_susceptibility3.19016508
4MP0003763_abnormal_thymus_physiology3.17300794
5MP0009278_abnormal_bone_marrow3.00530600
6MP0005671_abnormal_response_to2.84692537
7MP0003303_peritoneal_inflammation2.65261136
8MP0001800_abnormal_humoral_immune2.62034256
9MP0003300_gastrointestinal_ulcer2.61292973
10MP0002006_tumorigenesis2.55150451
11* MP0000703_abnormal_thymus_morphology2.51969607
12MP0000685_abnormal_immune_system2.47252516
13MP0005000_abnormal_immune_tolerance2.40212614
14MP0008260_abnormal_autophagy2.38930718
15* MP0002398_abnormal_bone_marrow2.38326596
16* MP0005387_immune_system_phenotype2.30247077
17* MP0001790_abnormal_immune_system2.30247077
18MP0002452_abnormal_antigen_presenting2.27807478
19MP0002420_abnormal_adaptive_immunity2.25589838
20MP0001819_abnormal_immune_cell2.23120708
21* MP0002723_abnormal_immune_serum2.18685326
22MP0006082_CNS_inflammation2.09780846
23* MP0004808_abnormal_hematopoietic_stem2.09142387
24MP0003436_decreased_susceptibility_to2.08934083
25MP0005076_abnormal_cell_differentiation2.06759702
26* MP0000716_abnormal_immune_system2.04934068
27MP0002396_abnormal_hematopoietic_system2.00411040
28MP0002419_abnormal_innate_immunity1.99235300
29* MP0004947_skin_inflammation1.98003748
30MP0009785_altered_susceptibility_to1.95612373
31* MP0002722_abnormal_immune_system1.95564901
32MP0010155_abnormal_intestine_physiology1.93430777
33MP0005025_abnormal_response_to1.92587714
34* MP0002405_respiratory_system_inflammati1.88372141
35MP0003705_abnormal_hypodermis_morpholog1.85182767
36* MP0000689_abnormal_spleen_morphology1.84174142
37MP0001545_abnormal_hematopoietic_system1.77361994
38MP0005397_hematopoietic_system_phenotyp1.77361994
39MP0010094_abnormal_chromosome_stability1.76015172
40MP0009333_abnormal_splenocyte_physiolog1.68334429
41MP0010307_abnormal_tumor_latency1.64150342
42* MP0002429_abnormal_blood_cell1.63594573
43MP0002148_abnormal_hypersensitivity_rea1.63430216
44MP0005464_abnormal_platelet_physiology1.63302108
45MP0010352_gastrointestinal_tract_polyps1.60885061
46MP0005451_abnormal_body_composition1.59259307
47MP0002132_abnormal_respiratory_system1.58136958
48MP0003172_abnormal_lysosome_physiology1.57512870
49MP0008961_abnormal_basal_metabolism1.53739563
50MP0001849_ear_inflammation1.48454675
51MP0002877_abnormal_melanocyte_morpholog1.46304071
52MP0004510_myositis1.40258393
53MP0002933_joint_inflammation1.38434476
54MP0000465_gastrointestinal_hemorrhage1.36301228
55MP0001873_stomach_inflammation1.33597539
56MP0005310_abnormal_salivary_gland1.32319637
57* MP0001845_abnormal_inflammatory_respons1.29182810
58MP0003448_altered_tumor_morphology1.29114532
59MP0008877_abnormal_DNA_methylation1.28616280
60MP0003183_abnormal_peptide_metabolism1.25289125
61MP0003191_abnormal_cellular_cholesterol1.23546162
62MP0004185_abnormal_adipocyte_glucose1.21761402
63MP0008057_abnormal_DNA_replication1.20366697
64MP0001851_eye_inflammation1.16301530
65MP0004883_abnormal_blood_vessel1.13466287
66MP0002009_preneoplasia1.12901272
67MP0000490_abnormal_crypts_of1.12308920
68MP0003866_abnormal_defecation1.12113770
69MP0002998_abnormal_bone_remodeling1.09042733
70MP0003045_fibrosis1.07732917
71MP0000383_abnormal_hair_follicle1.07426218
72MP0005621_abnormal_cell_physiology1.07071001
73MP0003221_abnormal_cardiomyocyte_apopto1.06274712
74MP0001730_embryonic_growth_arrest1.05970391
75MP0001853_heart_inflammation1.05855872
76* MP0005174_abnormal_tail_pigmentation1.04687532
77MP0000858_altered_metastatic_potential1.01483464
78MP0001533_abnormal_skeleton_physiology0.97087924
79MP0003111_abnormal_nucleus_morphology0.96965387
80MP0005058_abnormal_lysosome_morphology0.95607630
81MP0003453_abnormal_keratinocyte_physiol0.94361214
82MP0003724_increased_susceptibility_to0.93982721
83MP0001672_abnormal_embryogenesis/_devel0.93004433
84MP0005380_embryogenesis_phenotype0.93004433
85* MP0002095_abnormal_skin_pigmentation0.90875954
86MP0003787_abnormal_imprinting0.87348394
87MP0003656_abnormal_erythrocyte_physiolo0.86761789
88MP0003828_pulmonary_edema0.85866678
89MP0004957_abnormal_blastocyst_morpholog0.85830650
90MP0002019_abnormal_tumor_incidence0.85193044
91MP0010678_abnormal_skin_adnexa0.81404556
92MP0001879_abnormal_lymphatic_vessel0.81192922
93MP0004264_abnormal_extraembryonic_tissu0.80928389
94MP0000767_abnormal_smooth_muscle0.79995639
95MP0003077_abnormal_cell_cycle0.78210854
96MP0009672_abnormal_birth_weight0.76100863
97MP0003690_abnormal_glial_cell0.75602963
98MP0001697_abnormal_embryo_size0.75256334
99MP0004197_abnormal_fetal_growth/weight/0.75150565
100MP0005388_respiratory_system_phenotype0.73566379
101MP0002133_abnormal_respiratory_system0.73566379
102MP0000350_abnormal_cell_proliferation0.71912879
103MP0001216_abnormal_epidermal_layer0.70746967
104MP0000733_abnormal_muscle_development0.70484569
105MP0001191_abnormal_skin_condition0.70389398
106MP0005164_abnormal_response_to0.69899146
107MP0003091_abnormal_cell_migration0.68546640
108MP0000371_diluted_coat_color0.66224822
109MP0003566_abnormal_cell_adhesion0.65963832
110MP0000920_abnormal_myelination0.64622895
111* MP0002075_abnormal_coat/hair_pigmentati0.64573132
112MP0001915_intracranial_hemorrhage0.61978134
113MP0002925_abnormal_cardiovascular_devel0.61642334
114MP0004381_abnormal_hair_follicle0.61621611
115MP0005075_abnormal_melanosome_morpholog0.60309129
116* MP0000015_abnormal_ear_pigmentation0.60283457
117MP0008007_abnormal_cellular_replicative0.59266405
118MP0008770_decreased_survivor_rate0.57908484
119MP0000313_abnormal_cell_death0.57077589
120MP0002086_abnormal_extraembryonic_tissu0.56976352
121MP0008469_abnormal_protein_level0.56164303
122MP0002088_abnormal_embryonic_growth/wei0.54479419
123MP0003984_embryonic_growth_retardation0.53987587
124MP0001784_abnormal_fluid_regulation0.49971012

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.92029969
2Abnormality of T cell number (HP:0011839)5.59925784
3Abnormality of B cell number (HP:0010975)5.44683117
4B lymphocytopenia (HP:0010976)5.44683117
5Thyroiditis (HP:0100646)5.19762606
6Panhypogammaglobulinemia (HP:0003139)5.11656129
7Recurrent viral infections (HP:0004429)4.96461036
8Severe combined immunodeficiency (HP:0004430)4.65970320
9Eosinophilia (HP:0001880)4.39796680
10Hypoplasia of the thymus (HP:0000778)4.27990863
11Recurrent fungal infections (HP:0002841)4.22738961
12Combined immunodeficiency (HP:0005387)4.00097805
13Abnormality of the fingertips (HP:0001211)3.58464751
14Eczematoid dermatitis (HP:0000976)3.56332105
15Granulocytopenia (HP:0001913)3.48370387
16Hyperacusis (HP:0010780)3.40280904
17Recurrent abscess formation (HP:0002722)3.38904012
18Abnormality of eosinophils (HP:0001879)3.36481171
19Abnormality of T cells (HP:0002843)3.29831829
20Recurrent bacterial skin infections (HP:0005406)3.05384097
21Hypoproteinemia (HP:0003075)2.97777329
22Leukocytosis (HP:0001974)2.89091210
23Chronic otitis media (HP:0000389)2.82923688
24Subacute progressive viral hepatitis (HP:0006572)2.75179533
25Autoimmune thrombocytopenia (HP:0001973)2.73500792
26Meningitis (HP:0001287)2.70072591
27Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.65878981
28Abnormal platelet volume (HP:0011876)2.61192323
29Prolonged bleeding time (HP:0003010)2.56360773
30Viral hepatitis (HP:0006562)2.52187148
31Chronic mucocutaneous candidiasis (HP:0002728)2.50333540
32Recurrent cutaneous fungal infections (HP:0011370)2.50333540
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.46267564
34Gastrointestinal infarctions (HP:0005244)2.44623254
35IgG deficiency (HP:0004315)2.44324734
36Mediastinal lymphadenopathy (HP:0100721)2.43111730
37Nasal polyposis (HP:0100582)2.42622307
38Keratoconjunctivitis sicca (HP:0001097)2.39616071
39Elfin facies (HP:0004428)2.38042843
40Transitional cell carcinoma of the bladder (HP:0006740)2.37050334
41Volvulus (HP:0002580)2.34025223
42Obstructive lung disease (HP:0006536)2.31693451
43Chronic obstructive pulmonary disease (HP:0006510)2.31693451
44Myositis (HP:0100614)2.31240591
45Bladder neoplasm (HP:0009725)2.26820618
46Bladder carcinoma (HP:0002862)2.26820618
47Encephalitis (HP:0002383)2.25768022
48Disinhibition (HP:0000734)2.23782631
49Leiomyosarcoma (HP:0100243)2.23263641
50Uterine leiomyosarcoma (HP:0002891)2.23263641
51Slow saccadic eye movements (HP:0000514)2.21158383
52Inflammation of the large intestine (HP:0002037)2.19881761
53Overriding aorta (HP:0002623)2.19112768
54Amaurosis fugax (HP:0100576)2.19091788
55Recurrent skin infections (HP:0001581)2.18507887
56Cellulitis (HP:0100658)2.18486761
57Increased nuchal translucency (HP:0010880)2.18284750
58Papillary thyroid carcinoma (HP:0002895)2.16600313
59Increased mean platelet volume (HP:0011877)2.16164152
60Gingival bleeding (HP:0000225)2.15844270
61Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.15825796
62Epistaxis (HP:0000421)2.15672840
63Heterotopia (HP:0002282)2.14442627
64Absent frontal sinuses (HP:0002688)2.13199372
65Keratoconjunctivitis (HP:0001096)2.11775698
66Gastrointestinal inflammation (HP:0004386)2.09476741
67Upper motor neuron abnormality (HP:0002127)2.09292550
68Stomatitis (HP:0010280)2.08465610
69Macroorchidism (HP:0000053)2.08069892
70Renovascular hypertension (HP:0100817)2.08012920
71Periodontitis (HP:0000704)2.06979399
72Erythroderma (HP:0001019)2.06846378
73Gastrointestinal carcinoma (HP:0002672)2.06070804
74Malignant gastrointestinal tract tumors (HP:0006749)2.06070804
75Vertebral arch anomaly (HP:0008438)2.05807545
76Long eyelashes (HP:0000527)2.03916793
77Urticaria (HP:0001025)2.03173548
78Metaphyseal cupping (HP:0003021)2.02673565
79Pustule (HP:0200039)2.02060116
80Gingivitis (HP:0000230)2.01838485
81Spontaneous hematomas (HP:0007420)2.00526947
82Recurrent bronchitis (HP:0002837)1.98034698
83IgM deficiency (HP:0002850)1.95773777
84Basal cell carcinoma (HP:0002671)1.93547276
85Colitis (HP:0002583)1.92651560
86Abnormality of the nasal mucosa (HP:0000433)1.92599821
87Peritonitis (HP:0002586)1.92060850
88Sepsis (HP:0100806)1.90654875
89Elevated erythrocyte sedimentation rate (HP:0003565)1.90560424
90Retrobulbar optic neuritis (HP:0100654)1.89006613
91Optic neuritis (HP:0100653)1.89006613
92Acute myeloid leukemia (HP:0004808)1.87919188
93Abnormality of the distal phalanx of the thumb (HP:0009617)1.84298371
94Flat cornea (HP:0007720)1.83838045
95Hematochezia (HP:0002573)1.83370413
96Orchitis (HP:0100796)1.81542538
97Increased IgE level (HP:0003212)1.81387012
98Abnormality of macrophages (HP:0004311)1.80840676
99Lymphoma (HP:0002665)1.79768773
100Hemoptysis (HP:0002105)1.79592054
101Ankyloglossia (HP:0010296)1.79591305
102Abnormality of the columella (HP:0009929)1.78175603
103Ectopic kidney (HP:0000086)1.77218542
104Renal cell carcinoma (HP:0005584)1.76943872
105Cutis marmorata (HP:0000965)1.76873663
106Abnormality of the peritoneum (HP:0002585)1.76562415
107Aplasia/Hypoplasia of the thymus (HP:0010515)1.76399650
108Broad face (HP:0000283)1.75819322
109Acute lymphatic leukemia (HP:0006721)1.75188662
110Vasculitis (HP:0002633)1.74484423
111Conjunctival telangiectasia (HP:0000524)1.74228962
112Prominent nose (HP:0000448)1.74148802
113Abnormality of oral frenula (HP:0000190)1.72960034
114Obsessive-compulsive behavior (HP:0000722)1.72070220
115Papilloma (HP:0012740)1.71951959
116Verrucae (HP:0200043)1.71951959
117Agammaglobulinemia (HP:0004432)1.70884190
118Renal duplication (HP:0000075)1.70666938
119Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.69958543
120Dislocated radial head (HP:0003083)1.68247439
121Lymphopenia (HP:0001888)1.67474117
122Inappropriate behavior (HP:0000719)1.66862858
123Recurrent gram-negative bacterial infections (HP:0005420)1.66406969
124Narrow palate (HP:0000189)1.64893684
125Arterial thrombosis (HP:0004420)1.64492355
126Low anterior hairline (HP:0000294)1.64313680
127Abnormality of the vasculature of the conjunctiva (HP:0008054)1.64042662
128Spondylolisthesis (HP:0003302)1.63424498
129Abnormality of the thymus (HP:0000777)1.62773849
130Pulmonary infiltrates (HP:0002113)1.61085112
131Abnormality of cells of the lymphoid lineage (HP:0012140)1.60852701
132Bronchiectasis (HP:0002110)1.60599687
133Chest pain (HP:0100749)1.60526764
134Ureteral obstruction (HP:0006000)1.60287818
135Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.60257172
136Short 4th metacarpal (HP:0010044)1.60257172
137Osteomyelitis (HP:0002754)1.59787145
138Insomnia (HP:0100785)1.59439536
139Fatigue (HP:0012378)1.59000999
140Amyotrophic lateral sclerosis (HP:0007354)1.58665459
141Chronic sinusitis (HP:0011109)1.58080053
142Ureteral stenosis (HP:0000071)1.58006902
143Syringomyelia (HP:0003396)1.57499084
144Spinal cord lesions (HP:0100561)1.57499084
145Pulmonary embolism (HP:0002204)1.54256287
146Long palpebral fissure (HP:0000637)1.54151311
147Cortical dysplasia (HP:0002539)1.53950099
148Nephroblastoma (Wilms tumor) (HP:0002667)1.53604152
149Skin ulcer (HP:0200042)1.51810614

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.25130650
2TXK4.19672031
3CDK123.45726129
4PRPF4B2.88015270
5SIK22.66459888
6ZAP702.44592500
7MAP3K102.29781879
8STK102.12304399
9RIPK42.10814694
10TYK22.10260646
11FGR2.09835352
12ITK2.05024283
13FGFR31.90263494
14EEF2K1.89166899
15CAMK1G1.87416378
16CLK11.86021392
17BRD41.80421458
18CAMK1D1.77277816
19PNCK1.70289571
20SMG11.69128477
21KSR21.62978890
22JAK31.61447002
23* HCK1.60581824
24GRK61.60305116
25BTK1.57474609
26WNK11.54698056
27EPHB11.50871583
28* SYK1.48289239
29CSK1.43805216
30CDK61.43510710
31JAK11.41387394
32* LCK1.34900906
33IRAK41.34215970
34NEK21.31194648
35TAF11.27816460
36CSF1R1.27495656
37FGFR21.21352229
38NEK91.16894420
39MAPK71.15355614
40MAP3K141.13491528
41FES1.12221416
42DMPK1.08969259
43IRAK21.06810167
44STK41.05642545
45IRAK11.05558602
46STK241.04614175
47TEC1.03238022
48PKN21.02819149
49ALK1.02400350
50MAP3K71.02263105
51PTK61.01986953
52KSR11.01312982
53MARK21.00454179
54STK30.99576166
55CDK190.99445999
56TGFBR20.96327695
57CDK90.95952851
58FGFR40.95825963
59PRKCQ0.93396561
60SGK30.92526903
61CDK40.91457685
62* PDGFRB0.89050678
63BMX0.84468706
64PTK2B0.84168912
65BLK0.83886986
66* YES10.83676633
67KIT0.83254059
68TRIB30.83207805
69TAOK10.83079470
70CDC70.83017356
71PRKCH0.82116880
72HIPK20.81175590
73TAOK30.80965961
74IKBKE0.80895866
75JAK20.80599879
76LYN0.80521917
77MARK30.80310810
78PIM10.79705215
79LRRK20.79308107
80MAP3K130.76653268
81NLK0.71984857
82RPS6KA40.71404490
83MAP2K30.71234342
84CSNK1A1L0.70884746
85ATR0.69553585
86MAP3K80.69150606
87PASK0.69011472
88MAP3K30.68360843
89LATS10.67919031
90MAP3K10.67528483
91MTOR0.67347513
92RAF10.63738888
93TNK20.63652313
94CHUK0.63533187
95CDK30.62740706
96MAP3K60.61586077
97TBK10.60986080
98MELK0.60814465
99DYRK30.60444927
100PIK3CG0.60362763
101CAMKK10.60107065
102IKBKB0.59850843
103ERN10.59215672
104CAMK40.58939771
105MST40.57743613
106CAMKK20.57078756
107CHEK10.56399863
108PDK10.53577251
109MATK0.52462700
110MAPK120.51201906
111TRPM70.51105800
112STK110.50922956
113RPS6KC10.50735542
114RPS6KL10.50735542
115TYRO30.50695809
116TTN0.50589240
117RET0.50301041
118* FYN0.50069932
119PDGFRA0.47963601
120MAP3K90.47267185
121MAPK40.46778085
122SGK2230.46485507
123SGK4940.46485507
124* EGFR0.46461192
125CDC42BPA0.45936768
126* ABL10.45548138
127SIK30.45463385
128RIPK10.45042119
129ATM0.44910376
130NTRK20.44074006
131MAP3K20.43846484
132RPS6KA60.38510030
133MAPKAPK20.38508760
134SGK20.37140379
135NUAK10.37039594

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.67455525
2* T cell receptor signaling pathway_Homo sapiens_hsa046602.34150086
3B cell receptor signaling pathway_Homo sapiens_hsa046622.05209424
4Osteoclast differentiation_Homo sapiens_hsa043802.02946531
5Leishmaniasis_Homo sapiens_hsa051401.90392654
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.86599573
7Antigen processing and presentation_Homo sapiens_hsa046121.80908316
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.75661745
9Hematopoietic cell lineage_Homo sapiens_hsa046401.73676751
10Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.67408014
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.60888472
12Measles_Homo sapiens_hsa051621.58191637
13Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.58080943
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.50511697
15Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.46876975
16Non-homologous end-joining_Homo sapiens_hsa034501.44131143
17Dorso-ventral axis formation_Homo sapiens_hsa043201.41765475
18Chemokine signaling pathway_Homo sapiens_hsa040621.35693082
19* Chronic myeloid leukemia_Homo sapiens_hsa052201.35415347
20Leukocyte transendothelial migration_Homo sapiens_hsa046701.32913214
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.30594532
22Toxoplasmosis_Homo sapiens_hsa051451.30510565
23Acute myeloid leukemia_Homo sapiens_hsa052211.30257397
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.23208455
25Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18878578
26Hepatitis B_Homo sapiens_hsa051611.17970529
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17506068
28Colorectal cancer_Homo sapiens_hsa052101.17494078
29Viral myocarditis_Homo sapiens_hsa054161.17430360
30Neurotrophin signaling pathway_Homo sapiens_hsa047221.15992837
31Tuberculosis_Homo sapiens_hsa051521.12978560
32Pancreatic cancer_Homo sapiens_hsa052121.12639209
33Jak-STAT signaling pathway_Homo sapiens_hsa046301.10161093
34Non-small cell lung cancer_Homo sapiens_hsa052231.07433156
35Herpes simplex infection_Homo sapiens_hsa051681.07317992
36Influenza A_Homo sapiens_hsa051641.05309651
37Platelet activation_Homo sapiens_hsa046111.04831384
38Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00190813
39MicroRNAs in cancer_Homo sapiens_hsa052060.99458279
40Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99308372
41* Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99001136
42Endometrial cancer_Homo sapiens_hsa052130.99000592
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96841273
44Graft-versus-host disease_Homo sapiens_hsa053320.95991345
45HTLV-I infection_Homo sapiens_hsa051660.95856562
46Shigellosis_Homo sapiens_hsa051310.95156835
47Pertussis_Homo sapiens_hsa051330.94377375
48Staphylococcus aureus infection_Homo sapiens_hsa051500.93810601
49TNF signaling pathway_Homo sapiens_hsa046680.90906908
50VEGF signaling pathway_Homo sapiens_hsa043700.90480409
51Adherens junction_Homo sapiens_hsa045200.89751844
52FoxO signaling pathway_Homo sapiens_hsa040680.87869355
53Apoptosis_Homo sapiens_hsa042100.87813628
54Salmonella infection_Homo sapiens_hsa051320.86616925
55Lysine degradation_Homo sapiens_hsa003100.84821493
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84232356
57Small cell lung cancer_Homo sapiens_hsa052220.83874446
58Notch signaling pathway_Homo sapiens_hsa043300.83041081
59Prostate cancer_Homo sapiens_hsa052150.82931972
60mTOR signaling pathway_Homo sapiens_hsa041500.82619264
61Renal cell carcinoma_Homo sapiens_hsa052110.81488372
62Viral carcinogenesis_Homo sapiens_hsa052030.80992286
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80515530
64Allograft rejection_Homo sapiens_hsa053300.79364884
65Inositol phosphate metabolism_Homo sapiens_hsa005620.77442157
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.76397429
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75748177
68Glioma_Homo sapiens_hsa052140.74527789
69Prolactin signaling pathway_Homo sapiens_hsa049170.74253567
70GnRH signaling pathway_Homo sapiens_hsa049120.73857892
71Amoebiasis_Homo sapiens_hsa051460.73411274
72Phagosome_Homo sapiens_hsa041450.73256817
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71390450
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.70942934
75Legionellosis_Homo sapiens_hsa051340.69534151
76MAPK signaling pathway_Homo sapiens_hsa040100.69463067
77Focal adhesion_Homo sapiens_hsa045100.69057782
78Thyroid cancer_Homo sapiens_hsa052160.68558208
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68466974
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.68145001
81Choline metabolism in cancer_Homo sapiens_hsa052310.67675027
82Malaria_Homo sapiens_hsa051440.66996692
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66688952
84mRNA surveillance pathway_Homo sapiens_hsa030150.66592974
85Bladder cancer_Homo sapiens_hsa052190.66534697
86* Proteoglycans in cancer_Homo sapiens_hsa052050.65917966
87* Endocytosis_Homo sapiens_hsa041440.65869075
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.65598166
89Type II diabetes mellitus_Homo sapiens_hsa049300.65241034
90Epstein-Barr virus infection_Homo sapiens_hsa051690.63792142
91Carbohydrate digestion and absorption_Homo sapiens_hsa049730.63626194
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63231635
93Estrogen signaling pathway_Homo sapiens_hsa049150.62317067
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61746826
95Hepatitis C_Homo sapiens_hsa051600.61651124
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60539897
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60065757
98Long-term potentiation_Homo sapiens_hsa047200.60057179
99Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.58541630
100Rap1 signaling pathway_Homo sapiens_hsa040150.58252872
101* ErbB signaling pathway_Homo sapiens_hsa040120.56372821
102* Pathways in cancer_Homo sapiens_hsa052000.56034894
103Lysosome_Homo sapiens_hsa041420.55025854
104Ras signaling pathway_Homo sapiens_hsa040140.54570335
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53846054
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53258250
107Cell cycle_Homo sapiens_hsa041100.53244016
108African trypanosomiasis_Homo sapiens_hsa051430.52402299
109Asthma_Homo sapiens_hsa053100.51719301
110p53 signaling pathway_Homo sapiens_hsa041150.51384230
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51110033
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51079508
113Autoimmune thyroid disease_Homo sapiens_hsa053200.51033879
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50464973
115Other glycan degradation_Homo sapiens_hsa005110.50037446
116HIF-1 signaling pathway_Homo sapiens_hsa040660.49954657

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »