CAV2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)6.56525252
2regulation of sequestering of triglyceride (GO:0010889)4.73437675
3desmosome organization (GO:0002934)4.65194046
4regulation of cholesterol storage (GO:0010885)4.61551196
5retina vasculature morphogenesis in camera-type eye (GO:0061299)4.51471001
6brown fat cell differentiation (GO:0050873)4.42075792
7cell-substrate junction assembly (GO:0007044)4.33502313
8negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.94519158
9lymph vessel development (GO:0001945)3.90528282
10muscle cell migration (GO:0014812)3.84447853
11surfactant homeostasis (GO:0043129)3.83464120
12vascular endothelial growth factor signaling pathway (GO:0038084)3.80815221
13triglyceride catabolic process (GO:0019433)3.79634393
14white fat cell differentiation (GO:0050872)3.77080897
15positive regulation of macrophage cytokine production (GO:0060907)3.73884109
16endodermal cell differentiation (GO:0035987)3.73478422
17regulation of transforming growth factor beta2 production (GO:0032909)3.73387628
18regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.72079554
19skin morphogenesis (GO:0043589)3.71397900
20ovulation from ovarian follicle (GO:0001542)3.54370979
21hemidesmosome assembly (GO:0031581)3.51945501
22negative regulation of protein localization to cell surface (GO:2000009)3.47805125
23lipid storage (GO:0019915)3.43615606
24mesenchymal-epithelial cell signaling (GO:0060638)3.42547318
25apoptotic cell clearance (GO:0043277)3.39399706
26extracellular fibril organization (GO:0043206)3.37428439
27valine metabolic process (GO:0006573)3.36262029
28phagocytosis, recognition (GO:0006910)3.34583593
29mesodermal cell differentiation (GO:0048333)3.30842326
30neutral lipid catabolic process (GO:0046461)3.30215452
31acylglycerol catabolic process (GO:0046464)3.30215452
32cell adhesion mediated by integrin (GO:0033627)3.23898109
33regulation of macrophage derived foam cell differentiation (GO:0010743)3.22650607
34collagen fibril organization (GO:0030199)3.20236041
35negative regulation of anoikis (GO:2000811)3.18881141
36bundle of His cell to Purkinje myocyte communication (GO:0086069)3.18351158
37regulation of endothelial cell chemotaxis (GO:2001026)3.16748459
38barbed-end actin filament capping (GO:0051016)3.15154392
39fatty acid transmembrane transport (GO:1902001)3.13505675
40protein hydroxylation (GO:0018126)3.12949573
41negative regulation of lipid storage (GO:0010888)3.10178677
42lymphangiogenesis (GO:0001946)3.10172457
43regulation of endothelial cell differentiation (GO:0045601)3.08662562
44positive regulation of osteoblast proliferation (GO:0033690)3.05906093
45negative regulation of nitric-oxide synthase activity (GO:0051001)3.05265286
46lipid particle organization (GO:0034389)3.04659062
47regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.04590009
48renal filtration (GO:0097205)3.04361490
49negative regulation of protein autophosphorylation (GO:0031953)3.03943337
50negative regulation of chondrocyte differentiation (GO:0032331)3.03367465
51growth hormone receptor signaling pathway (GO:0060396)3.00482818
52cell migration involved in heart development (GO:0060973)3.00252766
53chemical homeostasis within a tissue (GO:0048875)2.99567634
54hypotonic response (GO:0006971)2.99346030
55keratinocyte proliferation (GO:0043616)2.99286073
56polyketide metabolic process (GO:0030638)2.94945324
57doxorubicin metabolic process (GO:0044598)2.94945324
58daunorubicin metabolic process (GO:0044597)2.94945324
59protein localization to cell surface (GO:0034394)2.94653214
60plasma membrane repair (GO:0001778)2.94578878
61glomerular filtration (GO:0003094)2.93330740
62antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.93327455
63cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.92469491
64regulation of vasculogenesis (GO:2001212)2.89917019
65type B pancreatic cell proliferation (GO:0044342)2.87593912
66substrate adhesion-dependent cell spreading (GO:0034446)2.85769993
67positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.85636253
68fibril organization (GO:0097435)2.85547234
69positive regulation of cell junction assembly (GO:1901890)2.83037536
70positive regulation of focal adhesion assembly (GO:0051894)2.83037536
71regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.82439014
72lung vasculature development (GO:0060426)2.81494193
73positive regulation of lipid storage (GO:0010884)2.78134241
74positive regulation of adherens junction organization (GO:1903393)2.77940715
75negative regulation of monooxygenase activity (GO:0032769)2.77498641
76actin filament depolymerization (GO:0030042)2.77333538
77positive regulation of glomerulus development (GO:0090193)2.76264873
78negative regulation of nitric oxide biosynthetic process (GO:0045019)2.76009198
79positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.75973000
80peptidyl-proline hydroxylation (GO:0019511)2.75906105
81regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.75756334
82pericardium development (GO:0060039)2.75664808
83positive regulation of fatty acid oxidation (GO:0046321)2.75420436
84regulation of macrophage cytokine production (GO:0010935)2.75046921
85protein heterotrimerization (GO:0070208)2.74680061
86cell-substrate adherens junction assembly (GO:0007045)2.74678197
87focal adhesion assembly (GO:0048041)2.74678197
88negative regulation of systemic arterial blood pressure (GO:0003085)2.74512589
89endocardial cushion development (GO:0003197)2.73102932
90regulation of metalloenzyme activity (GO:0048552)2.73005387
91stress fiber assembly (GO:0043149)2.72690894
92biotin metabolic process (GO:0006768)2.70239937
93wound healing, spreading of epidermal cells (GO:0035313)2.69112813
94atrioventricular valve morphogenesis (GO:0003181)2.68677431
95epithelial cell-cell adhesion (GO:0090136)2.68226117
96regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.67973040
97transcytosis (GO:0045056)2.67888025
98negative regulation of cartilage development (GO:0061037)2.67623065
99positive regulation of endothelial cell migration (GO:0010595)2.66986699
100positive regulation of smooth muscle cell migration (GO:0014911)2.66621259
101neuron projection extension involved in neuron projection guidance (GO:1902284)2.65200395
102axon extension involved in axon guidance (GO:0048846)2.65200395
103regulation of anoikis (GO:2000209)2.63577295
104negative regulation of fatty acid transport (GO:2000192)2.63438651
105heart trabecula formation (GO:0060347)2.61909967
106regulation of the force of heart contraction (GO:0002026)2.60680562
107positive regulation of blood vessel endothelial cell migration (GO:0043536)2.60589436
108endothelium development (GO:0003158)2.60309626
109adherens junction assembly (GO:0034333)2.60221113
110positive regulation of endothelial cell differentiation (GO:0045603)2.60021095
111substrate-dependent cell migration (GO:0006929)2.59763548
112extracellular matrix assembly (GO:0085029)2.59369893
113aminoglycoside antibiotic metabolic process (GO:0030647)2.58338791
114triglyceride biosynthetic process (GO:0019432)2.58254609
115endothelial cell morphogenesis (GO:0001886)2.57388424
116gap junction assembly (GO:0016264)2.56844168
117regulation of lipid storage (GO:0010883)2.56712306
118positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.56310406
119cellular response to growth hormone stimulus (GO:0071378)2.55662075
120positive regulation of receptor recycling (GO:0001921)2.55144693
121basement membrane organization (GO:0071711)2.55032957
122smooth muscle tissue development (GO:0048745)2.54673313
123negative regulation of cardiac muscle tissue growth (GO:0055022)2.54478590
124negative regulation of heart growth (GO:0061117)2.54478590
125blood vessel remodeling (GO:0001974)2.54041347
126acylglycerol biosynthetic process (GO:0046463)2.52719623
127neutral lipid biosynthetic process (GO:0046460)2.52719623
128response to increased oxygen levels (GO:0036296)2.52030896
129response to hyperoxia (GO:0055093)2.52030896
130positive regulation of epithelial cell migration (GO:0010634)2.51561872
131cellular response to vitamin D (GO:0071305)2.51333664
132positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.50492966
133* membrane raft organization (GO:0031579)2.50484990
134cellular response to vitamin (GO:0071295)2.50363316
135protein localization to endosome (GO:0036010)2.50255735
136positive regulation of fatty acid beta-oxidation (GO:0032000)2.49873364
137COPI coating of Golgi vesicle (GO:0048205)2.48723964
138Golgi transport vesicle coating (GO:0048200)2.48723964
139negative regulation of smooth muscle cell migration (GO:0014912)2.48337132
140sprouting angiogenesis (GO:0002040)2.48263379
141blood vessel maturation (GO:0001955)2.47994652
142regulation of receptor binding (GO:1900120)2.46945924
143kidney mesenchyme development (GO:0072074)2.46444454
144positive regulation of vasculogenesis (GO:2001214)2.46420829
145positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.46056698
146regulation of transforming growth factor beta1 production (GO:0032908)2.45641362
147regulation of plasminogen activation (GO:0010755)2.44656333
148dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.44605846
149cell-matrix adhesion (GO:0007160)2.43867178
150positive regulation of extracellular matrix organization (GO:1903055)2.43610534
151mammary gland development (GO:0030879)2.43319615
152negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.43079139
153endothelial cell chemotaxis (GO:0035767)2.42711520
154cellular response to lithium ion (GO:0071285)2.42247010
155regulation of integrin-mediated signaling pathway (GO:2001044)2.36180722
156regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.34597975
157fatty acid beta-oxidation (GO:0006635)2.32651585
158* membrane assembly (GO:0071709)2.32467333
159vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.32317713
160glycerolipid catabolic process (GO:0046503)2.31811944
161endothelial tube morphogenesis (GO:0061154)2.31585597
162morphogenesis of an endothelium (GO:0003159)2.31585597
163ovulation (GO:0030728)2.30411341
164positive regulation of cholesterol efflux (GO:0010875)2.30368896
165positive regulation of p38MAPK cascade (GO:1900745)2.30130039
166artery development (GO:0060840)2.30011427
167positive regulation of endothelial cell apoptotic process (GO:2000353)2.29155956
168plasma lipoprotein particle clearance (GO:0034381)2.29122611
169negative regulation of smooth muscle cell proliferation (GO:0048662)2.26907610
170lung lobe morphogenesis (GO:0060463)2.26897941
171positive regulation of glucose import (GO:0046326)2.26500076
172regulation of smooth muscle cell migration (GO:0014910)2.25600019
173iron ion import (GO:0097286)2.23726550
174endocrine hormone secretion (GO:0060986)2.21665528

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.51344807
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.67652578
3* TRIM28_21343339_ChIP-Seq_HEK293_Human3.25251122
4CLOCK_20551151_ChIP-Seq_293T_Human3.11126853
5* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.82083292
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.70592736
7TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.55154469
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.25797850
9GATA2_21666600_ChIP-Seq_HMVEC_Human2.21470640
10CDX2_19796622_ChIP-Seq_MESCs_Mouse2.14001687
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.10655701
12GATA1_22025678_ChIP-Seq_K562_Human2.07894268
13* CJUN_26792858_Chip-Seq_BT549_Human2.02550790
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.01907732
15* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.96492691
16NRF2_20460467_ChIP-Seq_MEFs_Mouse1.88433204
17NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.88433204
18EP300_21415370_ChIP-Seq_HL-1_Mouse1.82172769
19PPAR_26484153_Chip-Seq_NCI-H1993_Human1.81738934
20ELK3_25401928_ChIP-Seq_HUVEC_Human1.75932826
21CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.75443023
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73422711
23ZNF217_24962896_ChIP-Seq_MCF-7_Human1.71065086
24ESR1_21235772_ChIP-Seq_MCF-7_Human1.70220837
25SOX2_20726797_ChIP-Seq_SW620_Human1.69785747
26TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67358690
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66847229
28HIF1A_21447827_ChIP-Seq_MCF-7_Human1.66281025
29* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.65190359
30ATF3_27146783_Chip-Seq_COLON_Human1.65117179
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.63724017
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.63693184
33FOXO3_23340844_ChIP-Seq_DLD1_Human1.62675881
34SOX9_24532713_ChIP-Seq_HFSC_Mouse1.59003678
35* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.58152486
36BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.58121183
37* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.54960685
38MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.54045757
39* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53330231
40UBF1/2_26484160_Chip-Seq_HMECs_Human1.51829708
41BP1_19119308_ChIP-ChIP_Hs578T_Human1.50280201
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.49127084
43TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48738875
44ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.48216901
45* CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.46268578
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.41649980
47STAT6_21828071_ChIP-Seq_BEAS2B_Human1.40689053
48SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.39575172
49SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.39575172
50RXR_22108803_ChIP-Seq_LS180_Human1.38439720
51NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.37835949
52TP53_18474530_ChIP-ChIP_U2OS_Human1.37661340
53FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.36258800
54AHR_22903824_ChIP-Seq_MCF-7_Human1.34943300
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.34900138
56AR_21909140_ChIP-Seq_LNCAP_Human1.34622644
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.34274748
58P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34108279
59RXR_22158963_ChIP-Seq_LIVER_Mouse1.32109512
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.31387318
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.30748681
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30576380
63IRF8_22096565_ChIP-ChIP_GC-B_Human1.30430678
64SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23854096
65TBX20_22328084_ChIP-Seq_HEART_Mouse1.23799540
66TBX20_22080862_ChIP-Seq_HEART_Mouse1.23799540
67PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.22786717
68ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22732978
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22113525
70HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20927846
71VDR_24787735_ChIP-Seq_THP-1_Human1.20898666
72JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20147670
73* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.18498077
74NFIB_24661679_ChIP-Seq_LUNG_Mouse1.17669328
75LXR_22158963_ChIP-Seq_LIVER_Mouse1.16898808
76IRF8_21731497_ChIP-ChIP_J774_Mouse1.15566899
77BCAT_22108803_ChIP-Seq_LS180_Human1.15369564
78EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.14237332
79SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13266533
80* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.13231394
81UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.12726280
82P63_26484246_Chip-Seq_KERATINOCYTES_Human1.12628073
83WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11130519
84JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10622557
85SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09535593
86TCF4_18268006_ChIP-ChIP_LS174T_Human1.09509836
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.08944711
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.08483035
89CTNNB1_20460455_ChIP-Seq_HCT116_Human1.08184466
90SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06323128
91TP53_22127205_ChIP-Seq_IMR90_Human1.06170052
92EED_16625203_ChIP-ChIP_MESCs_Mouse1.05441080
93SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05432833
94STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.05320152
95RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05317729
96EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05317729
97CDX2_20551321_ChIP-Seq_CACO-2_Human1.05066832
98FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04563248
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03461474
100* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03145353
101IRF8_27001747_Chip-Seq_BMDM_Mouse1.01215507
102NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00827442
103RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00663455
104PPARA_22158963_ChIP-Seq_LIVER_Mouse0.99287366
105* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98680607
106TP53_23651856_ChIP-Seq_MEFs_Mouse0.97239004
107* MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97229942
108* BRD4_25478319_ChIP-Seq_HGPS_Human0.97184617
109RACK7_27058665_Chip-Seq_MCF-7_Human0.96779818
110GATA4_21415370_ChIP-Seq_HL-1_Mouse0.96598610
111* TP63_23658742_ChIP-Seq_EP156T_Human0.96368124
112NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95879180
113TP53_16413492_ChIP-PET_HCT116_Human0.95557475
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95260302
115PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94932610
116ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.93227485
117KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91964436
118GATA4_25053715_ChIP-Seq_YYC3_Human0.91741081
119EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91597764
120RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90536971
121ELK1_22589737_ChIP-Seq_MCF10A_Human0.90300415
122* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.90165165
123FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89623817
124AR_21572438_ChIP-Seq_LNCaP_Human0.88776728
125TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88760654
126SA1_22415368_ChIP-Seq_MEFs_Mouse0.88726840
127GATA3_24758297_ChIP-Seq_MCF-7_Human0.88328229
128SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.86285156
129* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.85606416
130ZNF263_19887448_ChIP-Seq_K562_Human0.85595435
131TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.85445455
132MYB_21317192_ChIP-Seq_ERMYB_Mouse0.85351850
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84412061
134SMC3_22415368_ChIP-Seq_MEFs_Mouse0.82385092
135NR3C1_23031785_ChIP-Seq_PC12_Mouse0.81962826
136KLF5_25053715_ChIP-Seq_YYC3_Human0.80678946
137POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.80050706
138* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.78994493

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose4.25060516
2MP0008438_abnormal_cutaneous_collagen3.78610564
3MP0004130_abnormal_muscle_cell3.42242946
4MP0003191_abnormal_cellular_cholesterol3.32239196
5MP0003705_abnormal_hypodermis_morpholog3.27236272
6MP0003724_increased_susceptibility_to3.19088570
7MP0001879_abnormal_lymphatic_vessel3.06861881
8MP0005666_abnormal_adipose_tissue3.00077341
9MP0009780_abnormal_chondrocyte_physiolo2.92530723
10MP0004185_abnormal_adipocyte_glucose2.88021715
11MP0005275_abnormal_skin_tensile2.76809510
12MP0003828_pulmonary_edema2.68423679
13MP0003950_abnormal_plasma_membrane2.58076224
14MP0000013_abnormal_adipose_tissue2.56022359
15MP0005167_abnormal_blood-brain_barrier2.49753311
16MP0010368_abnormal_lymphatic_system2.40857285
17MP0005503_abnormal_tendon_morphology2.30286505
18MP0005375_adipose_tissue_phenotype2.27725437
19* MP0004272_abnormal_basement_membrane2.24137316
20MP0001958_emphysema2.02578576
21MP0000749_muscle_degeneration1.90004824
22MP0000762_abnormal_tongue_morphology1.85365927
23MP0005257_abnormal_intraocular_pressure1.85158086
24MP0003045_fibrosis1.81625007
25MP0004782_abnormal_surfactant_physiolog1.73746586
26MP0002971_abnormal_brown_adipose1.73307608
27MP0000343_altered_response_to1.73277111
28MP0005164_abnormal_response_to1.71880292
29MP0000003_abnormal_adipose_tissue1.70850233
30MP0009115_abnormal_fat_cell1.69292219
31MP0002837_dystrophic_cardiac_calcinosis1.62377464
32MP0003566_abnormal_cell_adhesion1.61273331
33MP0003941_abnormal_skin_development1.60859261
34MP0006138_congestive_heart_failure1.57296988
35MP0002295_abnormal_pulmonary_circulatio1.51103027
36MP0002166_altered_tumor_susceptibility1.45515432
37MP0010234_abnormal_vibrissa_follicle1.44754833
38MP0003279_aneurysm1.42978615
39MP0003690_abnormal_glial_cell1.42241678
40* MP0002332_abnormal_exercise_endurance1.41999606
41MP0002876_abnormal_thyroid_physiology1.33140201
42MP0005334_abnormal_fat_pad1.31022692
43MP0000733_abnormal_muscle_development1.27986444
44MP0005388_respiratory_system_phenotype1.25214520
45MP0002133_abnormal_respiratory_system1.25214520
46MP0009053_abnormal_anal_canal1.24661150
47MP0001881_abnormal_mammary_gland1.23820745
48MP0003091_abnormal_cell_migration1.23817032
49MP0004883_abnormal_blood_vessel1.23137334
50MP0002006_tumorigenesis1.23028270
51MP0002060_abnormal_skin_morphology1.22659158
52MP0005385_cardiovascular_system_phenoty1.20794282
53MP0001544_abnormal_cardiovascular_syste1.20794282
54MP0010329_abnormal_lipoprotein_level1.20637211
55MP0001533_abnormal_skeleton_physiology1.20324815
56MP0003300_gastrointestinal_ulcer1.17121111
57MP0010030_abnormal_orbit_morphology1.16376819
58MP0002254_reproductive_system_inflammat1.16149054
59MP0002796_impaired_skin_barrier1.15374383
60MP0006054_spinal_hemorrhage1.15332095
61MP0004036_abnormal_muscle_relaxation1.14900282
62MP0002108_abnormal_muscle_morphology1.14213603
63MP0005595_abnormal_vascular_smooth1.14155365
64MP0005165_increased_susceptibility_to1.12686809
65MP0008775_abnormal_heart_ventricle1.11981778
66* MP0000759_abnormal_skeletal_muscle1.11804162
67MP0000467_abnormal_esophagus_morphology1.10987941
68MP0003075_altered_response_to1.10781909
69MP0000249_abnormal_blood_vessel1.10174712
70MP0002168_other_aberrant_phenotype1.09186260
71MP0002972_abnormal_cardiac_muscle1.08788291
72* MP0004087_abnormal_muscle_fiber1.08297988
73MP0001542_abnormal_bone_strength1.07724548
74MP0003448_altered_tumor_morphology1.07640992
75MP0002009_preneoplasia1.06285724
76MP0003186_abnormal_redox_activity1.06026374
77MP0005623_abnormal_meninges_morphology1.05282656
78MP0000579_abnormal_nail_morphology1.04496681
79MP0000767_abnormal_smooth_muscle1.04097297
80MP0001853_heart_inflammation1.03636518
81MP0005508_abnormal_skeleton_morphology1.01061075
82MP0001299_abnormal_eye_distance/1.00982385
83MP0004484_altered_response_of0.99432621
84MP0009764_decreased_sensitivity_to0.98009946
85MP0005501_abnormal_skin_physiology0.97990668
86MP0005171_absent_coat_pigmentation0.97799866
87MP0005409_darkened_coat_color0.97342555
88MP0004147_increased_porphyrin_level0.97178304
89MP0005620_abnormal_muscle_contractility0.96744451
90MP0002998_abnormal_bone_remodeling0.96281328
91MP0001216_abnormal_epidermal_layer0.92460144
92MP0004233_abnormal_muscle_weight0.90073688
93MP0004215_abnormal_myocardial_fiber0.89670294
94MP0009785_altered_susceptibility_to0.88393267
95MP0009278_abnormal_bone_marrow0.88279272
96MP0010771_integument_phenotype0.88245867
97MP0002118_abnormal_lipid_homeostasis0.87795576
98MP0004084_abnormal_cardiac_muscle0.87785235
99MP0005397_hematopoietic_system_phenotyp0.87783068
100MP0001545_abnormal_hematopoietic_system0.87783068
101MP0001177_atelectasis0.87209785
102MP0005535_abnormal_body_temperature0.85977998
103MP0001243_abnormal_dermal_layer0.85669089
104MP0005058_abnormal_lysosome_morphology0.85633886
105MP0002970_abnormal_white_adipose0.85292348
106MP0005360_urolithiasis0.83969802
107MP0002234_abnormal_pharynx_morphology0.82389584
108MP0002269_muscular_atrophy0.82166790
109MP0000858_altered_metastatic_potential0.81262148
110MP0003868_abnormal_feces_composition0.80903633
111MP0002128_abnormal_blood_circulation0.80712790
112MP0001661_extended_life_span0.79393147
113MP0003303_peritoneal_inflammation0.79349737
114MP0000230_abnormal_systemic_arterial0.79271055
115MP0005197_abnormal_uvea_morphology0.78898479
116MP0009384_cardiac_valve_regurgitation0.78565137
117MP0001614_abnormal_blood_vessel0.77712968
118MP0001851_eye_inflammation0.77319005
119MP0005023_abnormal_wound_healing0.75822892
120MP0001756_abnormal_urination0.75267639
121MP0003959_abnormal_lean_body0.74887866
122MP0000627_abnormal_mammary_gland0.72792529
123MP0005330_cardiomyopathy0.72674614
124* MP0000750_abnormal_muscle_regeneration0.72454173
125MP0010630_abnormal_cardiac_muscle0.72190150
126MP0010352_gastrointestinal_tract_polyps0.71367695
127MP0002896_abnormal_bone_mineralization0.70682946
128MP0009250_abnormal_appendicular_skeleto0.70174134
129MP0002877_abnormal_melanocyte_morpholog0.69352681
130MP0010678_abnormal_skin_adnexa0.67664460
131MP0000163_abnormal_cartilage_morphology0.66295314
132MP0005193_abnormal_anterior_eye0.65716116
133MP0003453_abnormal_keratinocyte_physiol0.65516357
134MP0001915_intracranial_hemorrhage0.65477133
135MP0000751_myopathy0.64672708
136MP0002090_abnormal_vision0.64496271
137MP0009697_abnormal_copulation0.64382963
138MP0000747_muscle_weakness0.63537891

Predicted human phenotypes

RankGene SetZ-score
1Acanthosis nigricans (HP:0000956)5.54477746
2Oligomenorrhea (HP:0000876)4.84543113
3Hematochezia (HP:0002573)4.20954754
4Growth hormone excess (HP:0000845)4.09687232
5Reduced subcutaneous adipose tissue (HP:0003758)4.08961284
6Hypertriglyceridemia (HP:0002155)3.90771182
7Bone cyst (HP:0012062)3.81872737
8Increased connective tissue (HP:0009025)3.66223804
9Distal lower limb muscle weakness (HP:0009053)3.31737485
10Cerebral aneurysm (HP:0004944)3.18653037
11Premature rupture of membranes (HP:0001788)3.14584275
12Atrophic scars (HP:0001075)3.08530446
13Glucose intolerance (HP:0000833)2.99259166
14Polycythemia (HP:0001901)2.96591325
15Spinal rigidity (HP:0003306)2.92302104
16Wormian bones (HP:0002645)2.92285119
17Aortic dissection (HP:0002647)2.86559035
18Tetraparesis (HP:0002273)2.82767015
19Soft skin (HP:0000977)2.79297898
20Cardiovascular calcification (HP:0011915)2.77551340
21Broad metatarsal (HP:0001783)2.77039684
22Aortic aneurysm (HP:0004942)2.76340386
23Right ventricular cardiomyopathy (HP:0011663)2.75458936
24Short nail (HP:0001799)2.74194918
25Alopecia of scalp (HP:0002293)2.68707816
26Myocardial infarction (HP:0001658)2.68377127
27Increased variability in muscle fiber diameter (HP:0003557)2.64007262
28Osteolytic defects of the hand bones (HP:0009699)2.63979501
29Osteolytic defects of the phalanges of the hand (HP:0009771)2.63979501
30Bladder diverticulum (HP:0000015)2.63615665
31Esophageal varix (HP:0002040)2.61542754
32Distal lower limb amyotrophy (HP:0008944)2.59821001
33Abnormality of the nasal mucosa (HP:0000433)2.59232570
34Insulin-resistant diabetes mellitus (HP:0000831)2.59111673
35Vertebral compression fractures (HP:0002953)2.55552501
36Difficulty running (HP:0009046)2.54244159
37Interstitial pulmonary disease (HP:0006530)2.52604232
38Spondylolisthesis (HP:0003302)2.52486809
39Follicular hyperkeratosis (HP:0007502)2.51858525
40Ankle contracture (HP:0006466)2.51671824
41Hemorrhage of the eye (HP:0011885)2.49243770
42Mitral stenosis (HP:0001718)2.48875658
43Hyporeflexia of lower limbs (HP:0002600)2.48247401
44Mildly elevated creatine phosphokinase (HP:0008180)2.46797560
45Venous abnormality (HP:0002624)2.45291711
46Xerostomia (HP:0000217)2.44673537
47Muscle fiber splitting (HP:0003555)2.43685863
48Vascular tortuosity (HP:0004948)2.43171032
49Spontaneous hematomas (HP:0007420)2.43063222
50Insulin resistance (HP:0000855)2.42860204
51Onycholysis (HP:0001806)2.42057013
52Thick nail (HP:0001805)2.40661855
53Neck muscle weakness (HP:0000467)2.39758957
54Fragile nails (HP:0001808)2.39506296
55Cervical subluxation (HP:0003308)2.38804023
56Hypoplasia of the iris (HP:0007676)2.37840246
57Pigmentary retinal degeneration (HP:0001146)2.37746840
58Abnormality of proline metabolism (HP:0010907)2.36072040
59Hydroxyprolinuria (HP:0003080)2.36072040
60Cerebral hemorrhage (HP:0001342)2.35867326
61Natal tooth (HP:0000695)2.34181234
62Mucosal telangiectasiae (HP:0100579)2.34149448
63Arterial tortuosity (HP:0005116)2.34127578
64Vascular calcification (HP:0004934)2.31749582
65Asymmetric septal hypertrophy (HP:0001670)2.31660862
66Abnormality of skeletal muscle fiber size (HP:0012084)2.30916198
67Abnormal glucose tolerance (HP:0001952)2.30640447
68Type 1 muscle fiber predominance (HP:0003803)2.29054214
69Lipoatrophy (HP:0100578)2.27504558
70Prominent supraorbital ridges (HP:0000336)2.25724063
71Eczematoid dermatitis (HP:0000976)2.25127372
72Large hands (HP:0001176)2.24894391
73Elbow flexion contracture (HP:0002987)2.24805353
74Mitral valve prolapse (HP:0001634)2.24456700
75Bradycardia (HP:0001662)2.23809226
76Hyperpituitarism (HP:0010514)2.19432948
77Facial diplegia (HP:0001349)2.18524113
78Aplasia involving bones of the extremities (HP:0009825)2.18336209
79Aplasia involving bones of the upper limbs (HP:0009823)2.18336209
80Aplasia of the phalanges of the hand (HP:0009802)2.18336209
81Plantar hyperkeratosis (HP:0007556)2.14458061
82Hyperthyroidism (HP:0000836)2.14433295
83Complement deficiency (HP:0004431)2.12977885
84Ventricular tachycardia (HP:0004756)2.12729633
85Aortic regurgitation (HP:0001659)2.12421131
86Milia (HP:0001056)2.10630072
87Subcapsular cataract (HP:0000523)2.10122799
88Blue sclerae (HP:0000592)2.10049411
89Hyperglycinuria (HP:0003108)2.09466630
90Generalized amyotrophy (HP:0003700)2.08603323
91Pterygium (HP:0001059)2.07764626
92Nail dystrophy (HP:0008404)2.06341291
93Mitral regurgitation (HP:0001653)2.06331775
94Hypercholesterolemia (HP:0003124)2.05565343
95Popliteal pterygium (HP:0009756)2.04943716
96Tubulointerstitial fibrosis (HP:0005576)2.03384373
97Camptodactyly of toe (HP:0001836)2.03350827
98Visceral angiomatosis (HP:0100761)2.02048051
99Fragile skin (HP:0001030)2.01414243
100Protrusio acetabuli (HP:0003179)2.00873479
101Congenital, generalized hypertrichosis (HP:0004540)2.00386576
102Myoglobinuria (HP:0002913)1.99488489
103Pulmonary hypertension (HP:0002092)1.98885516
104Venous insufficiency (HP:0005293)1.98433759
105Aneurysm (HP:0002617)1.97475105
106Wrist flexion contracture (HP:0001239)1.97335062
107Hypoalphalipoproteinemia (HP:0003233)1.97075731
108Cavernous hemangioma (HP:0001048)1.93975113
109Muscle stiffness (HP:0003552)1.93714360
110Abnormal hemoglobin (HP:0011902)1.92117005
111Ridged nail (HP:0001807)1.91916334
112Recurrent gram-negative bacterial infections (HP:0005420)1.91553065
113Aortic valve stenosis (HP:0001650)1.90910303
114Autoimmune thrombocytopenia (HP:0001973)1.90766222
115Rectal prolapse (HP:0002035)1.90478604
116Ulnar bowing (HP:0003031)1.90338960
117Long foot (HP:0001833)1.90038007
118Bundle branch block (HP:0011710)1.88064384
119Chondrocalcinosis (HP:0000934)1.87997342
120Abnormality of the calf musculature (HP:0001430)1.87936472
121Shallow orbits (HP:0000586)1.87029804
122Nephritis (HP:0000123)1.86790989
123Sudden death (HP:0001699)1.86067132
124Subacute progressive viral hepatitis (HP:0006572)1.85928526
125Lower limb amyotrophy (HP:0007210)1.85608626
126Systemic lupus erythematosus (HP:0002725)1.84188188
127Hemangiomatosis (HP:0007461)1.82574647
128Gowers sign (HP:0003391)1.82413968
129Dilatation of the ascending aorta (HP:0005111)1.80917061
130Hepatosplenomegaly (HP:0001433)1.80698771
131Trismus (HP:0000211)1.80416525
132Entropion (HP:0000621)1.80132649
133Short hallux (HP:0010109)1.79759771
134Atrial fibrillation (HP:0005110)1.79366030
135Abnormal delivery (HP:0001787)1.79092364
136Amyloidosis (HP:0011034)1.78519813
137Abnormality of the lumbar spine (HP:0100712)1.77787163
138Difficulty climbing stairs (HP:0003551)1.77332391
139Exercise-induced muscle cramps (HP:0003710)1.77288235
140Joint laxity (HP:0001388)1.77001847
141Nausea (HP:0002018)1.76911642
142Abnormality of dentin (HP:0010299)1.76619438
143Ectopia lentis (HP:0001083)1.76430472
144Abnormal atrioventricular conduction (HP:0005150)1.76143591
145Knee flexion contracture (HP:0006380)1.75754738
146Increased cerebral lipofuscin (HP:0011813)1.75695891
147Abnormality of Sharpey fibers (HP:0100685)1.75474242
148Hydroureter (HP:0000072)1.75440692
149Accelerated skeletal maturation (HP:0005616)1.75378402
150Achilles tendon contracture (HP:0001771)1.75288795
151Abnormality of the acetabulum (HP:0003170)1.74911642
152Fatigable weakness (HP:0003473)1.73829349
153Abnormality of the neuromuscular junction (HP:0003398)1.73829349
154Upper limb amyotrophy (HP:0009129)1.73493206
155Distal upper limb amyotrophy (HP:0007149)1.73493206
156Round ear (HP:0100830)1.73420504
157Abnormality of complement system (HP:0005339)1.73295504
158Thin skin (HP:0000963)1.73168533
159Striae distensae (HP:0001065)1.73092314
160Scapular winging (HP:0003691)1.72833433
161Abnormality of the intrinsic pathway (HP:0010989)1.72361570
162Coronal craniosynostosis (HP:0004440)1.71865819

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.70569349
2TGFBR22.90881192
3TRIB32.85584805
4CAMK1D2.83695694
5FRK2.68911481
6MST1R2.51833297
7LMTK22.47579573
8PDK22.29244637
9LIMK12.28275223
10RIPK12.26757445
11EPHB22.25514667
12FER2.19924897
13ERN12.11565119
14SIK12.06021581
15TTN2.00399330
16MST41.96355081
17MAP3K121.94812463
18MYLK1.87573608
19PDK41.82798675
20PDK31.82798675
21CAMK1G1.80130120
22KDR1.61807755
23MUSK1.51957903
24PDGFRA1.51241448
25ERBB41.51168168
26FGFR31.49370629
27NEK91.38262646
28CDK81.38166652
29FGFR21.37702912
30PTK2B1.36428703
31TRPM71.28440442
32LRRK21.25616645
33FLT31.24965720
34MET1.18554311
35ARAF1.14529114
36MAP3K31.13808469
37DDR21.10799877
38CASK1.10408605
39BCKDK1.09221955
40MAP2K11.08510512
41LATS11.08152605
42JAK11.04158619
43PIK3CA1.02487981
44DMPK1.01455124
45PTK61.00587658
46SCYL20.99785696
47NME20.99769320
48MAP3K140.99226404
49INSRR0.98485165
50TGFBR10.98309993
51TBK10.96784858
52STK38L0.94341816
53MAP3K60.90284835
54EPHB10.89949560
55MAP3K20.89576922
56DAPK20.88754379
57STK380.87231416
58CAMKK20.86064915
59PKN20.85329513
60PRKG20.85048847
61AKT30.82202558
62EPHA30.81419742
63ERBB30.81118591
64PIM20.80848921
65GRK10.80360140
66PRKCH0.78815794
67EIF2AK10.77763851
68PRKCE0.77232310
69PHKG10.76520947
70PHKG20.76520947
71CSK0.75898580
72PIK3CG0.74909064
73PRKAA20.74830697
74BMX0.73689355
75PDGFRB0.73024127
76ROCK20.71277652
77CDK60.70153267
78IGF1R0.69390773
79TYK20.68964292
80MELK0.67704439
81PDPK10.67239032
82RET0.64912056
83JAK20.64705834
84FGFR40.64220968
85RIPK40.63266797
86STK100.61952094
87GSK3A0.61662665
88PRKD20.61398030
89MAPKAPK30.59893726
90PRKD10.59178756
91MOS0.59044691
92INSR0.58831208
93EPHA20.58251650
94STK30.57949859
95PAK40.57707411
96LATS20.57519892
97PBK0.56909094
98BCR0.55453622
99ILK0.55223223
100PTK20.53644159
101ABL10.53317061
102ROCK10.53253886
103NEK10.50435318
104DAPK30.50344969
105STK240.49153968
106ABL20.48636998
107PAK20.48623240
108GRK70.48219947
109CAMK2G0.48186406
110TESK10.47411649
111GRK50.47281972
112* SRC0.46000563
113JAK30.45653908
114MTOR0.42359322
115FGFR10.41954313
116CDK90.41714531
117NTRK10.41629503
118IRAK30.41333976
119ADRBK10.39474501
120MAP2K30.39145805
121CDC42BPA0.38898986
122PAK10.38554347
123PDK10.38371103
124FGR0.37817541
125EIF2AK30.36940270
126CAMK2D0.36772838
127MAPKAPK50.36441849
128SIK30.27290505
129AKT20.26939107
130ICK0.26294509
131MAPKAPK20.23336911
132CAMK2B0.23330006
133CCNB10.21045441
134BRSK20.20989286
135MAP3K80.19377756

Predicted pathways (KEGG)

RankGene SetZ-score
1Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.19198210
2Fatty acid biosynthesis_Homo sapiens_hsa000613.07478034
3PPAR signaling pathway_Homo sapiens_hsa033202.82158213
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.21802969
5Propanoate metabolism_Homo sapiens_hsa006402.20658784
6ECM-receptor interaction_Homo sapiens_hsa045122.10547113
7Fatty acid metabolism_Homo sapiens_hsa012121.89277835
8Sulfur metabolism_Homo sapiens_hsa009201.79144795
9Adipocytokine signaling pathway_Homo sapiens_hsa049201.78355590
10* Focal adhesion_Homo sapiens_hsa045101.68824257
11Malaria_Homo sapiens_hsa051441.66856113
12Fatty acid degradation_Homo sapiens_hsa000711.66277782
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.58520407
14Glycerolipid metabolism_Homo sapiens_hsa005611.47813022
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.44781828
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.42359309
17Staphylococcus aureus infection_Homo sapiens_hsa051501.38733307
18Amoebiasis_Homo sapiens_hsa051461.36246197
19Adherens junction_Homo sapiens_hsa045201.33872606
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.29013130
21Leukocyte transendothelial migration_Homo sapiens_hsa046701.28861412
22Rheumatoid arthritis_Homo sapiens_hsa053231.27196076
23Phagosome_Homo sapiens_hsa041451.26023522
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20319992
25Hippo signaling pathway_Homo sapiens_hsa043901.19437492
26Caffeine metabolism_Homo sapiens_hsa002321.17293248
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.17098401
28Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.12407815
29* Proteoglycans in cancer_Homo sapiens_hsa052051.12068732
30Pentose phosphate pathway_Homo sapiens_hsa000301.11111098
31Lysosome_Homo sapiens_hsa041421.10038266
32Renin secretion_Homo sapiens_hsa049241.09667329
33Insulin resistance_Homo sapiens_hsa049311.09557422
34AMPK signaling pathway_Homo sapiens_hsa041521.09080132
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.08779964
36Galactose metabolism_Homo sapiens_hsa000521.08309063
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05888273
38Pertussis_Homo sapiens_hsa051331.04608043
39Glutathione metabolism_Homo sapiens_hsa004801.01830010
40Viral myocarditis_Homo sapiens_hsa054161.01055862
41Toxoplasmosis_Homo sapiens_hsa051450.98208575
42Fatty acid elongation_Homo sapiens_hsa000620.95529243
43Dilated cardiomyopathy_Homo sapiens_hsa054140.95131767
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94477818
45* Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94380138
46Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91579088
47Small cell lung cancer_Homo sapiens_hsa052220.90625004
48HIF-1 signaling pathway_Homo sapiens_hsa040660.89588206
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.88531961
50Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.84874792
51Melanoma_Homo sapiens_hsa052180.84630288
52Histidine metabolism_Homo sapiens_hsa003400.84247141
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84243193
54Shigellosis_Homo sapiens_hsa051310.83109899
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82880551
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82335157
57Starch and sucrose metabolism_Homo sapiens_hsa005000.80648311
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.80312043
59Platelet activation_Homo sapiens_hsa046110.80112977
60Osteoclast differentiation_Homo sapiens_hsa043800.80078480
61Prion diseases_Homo sapiens_hsa050200.79728293
62Salmonella infection_Homo sapiens_hsa051320.79696293
63Circadian rhythm_Homo sapiens_hsa047100.78307478
64beta-Alanine metabolism_Homo sapiens_hsa004100.78191815
65Legionellosis_Homo sapiens_hsa051340.77846088
66TNF signaling pathway_Homo sapiens_hsa046680.77330436
67Rap1 signaling pathway_Homo sapiens_hsa040150.76639046
68Tight junction_Homo sapiens_hsa045300.76376549
69Chronic myeloid leukemia_Homo sapiens_hsa052200.75520097
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74936849
71Tuberculosis_Homo sapiens_hsa051520.74478299
72Insulin signaling pathway_Homo sapiens_hsa049100.74469391
73MicroRNAs in cancer_Homo sapiens_hsa052060.74159678
74PI3K-Akt signaling pathway_Homo sapiens_hsa041510.73734366
75Leishmaniasis_Homo sapiens_hsa051400.72954399
76Retinol metabolism_Homo sapiens_hsa008300.72514620
77African trypanosomiasis_Homo sapiens_hsa051430.71179648
78Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70932065
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.69451114
80Axon guidance_Homo sapiens_hsa043600.69342754
81Steroid hormone biosynthesis_Homo sapiens_hsa001400.69168679
82Protein digestion and absorption_Homo sapiens_hsa049740.69005494
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67529302
84Sphingolipid metabolism_Homo sapiens_hsa006000.67424028
85Thyroid cancer_Homo sapiens_hsa052160.66081561
86Folate biosynthesis_Homo sapiens_hsa007900.65875984
87Collecting duct acid secretion_Homo sapiens_hsa049660.64714361
88p53 signaling pathway_Homo sapiens_hsa041150.64141605
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.64086987
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63781284
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63516828
92Vibrio cholerae infection_Homo sapiens_hsa051100.63194023
93Pyruvate metabolism_Homo sapiens_hsa006200.62671663
94Renal cell carcinoma_Homo sapiens_hsa052110.61791057
95Renin-angiotensin system_Homo sapiens_hsa046140.61614429
96Complement and coagulation cascades_Homo sapiens_hsa046100.61506866
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61203642
98Chemical carcinogenesis_Homo sapiens_hsa052040.60776387
99Fructose and mannose metabolism_Homo sapiens_hsa000510.60634979
100Sulfur relay system_Homo sapiens_hsa041220.59922191
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.59764418
102Mineral absorption_Homo sapiens_hsa049780.59480152
103Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59432617
104TGF-beta signaling pathway_Homo sapiens_hsa043500.58411191
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.58151792
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57126265
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57058989
108Phenylalanine metabolism_Homo sapiens_hsa003600.56001956
109Hepatitis C_Homo sapiens_hsa051600.55358812
110Carbon metabolism_Homo sapiens_hsa012000.54738392
111Hematopoietic cell lineage_Homo sapiens_hsa046400.54291056
112Salivary secretion_Homo sapiens_hsa049700.52519800
113Peroxisome_Homo sapiens_hsa041460.52287430
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.50873127
115Gap junction_Homo sapiens_hsa045400.50259575
116Prostate cancer_Homo sapiens_hsa052150.49997024
117Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48895334
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.48802557
119Ras signaling pathway_Homo sapiens_hsa040140.48338659
120Glioma_Homo sapiens_hsa052140.48335931
121Bladder cancer_Homo sapiens_hsa052190.48090073
122Bile secretion_Homo sapiens_hsa049760.47929197
123Dorso-ventral axis formation_Homo sapiens_hsa043200.47857192
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46798320
125* Endocytosis_Homo sapiens_hsa041440.46701084
126Pathways in cancer_Homo sapiens_hsa052000.46570530
127Arginine and proline metabolism_Homo sapiens_hsa003300.45919870
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45042387
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.44877536
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.44402387
131Pancreatic cancer_Homo sapiens_hsa052120.42956341
132Jak-STAT signaling pathway_Homo sapiens_hsa046300.42866691
133N-Glycan biosynthesis_Homo sapiens_hsa005100.42752340
134VEGF signaling pathway_Homo sapiens_hsa043700.42701234
135Type II diabetes mellitus_Homo sapiens_hsa049300.42212791
136Fat digestion and absorption_Homo sapiens_hsa049750.41648883
137cAMP signaling pathway_Homo sapiens_hsa040240.41129794
138Gastric acid secretion_Homo sapiens_hsa049710.40872584
139Tyrosine metabolism_Homo sapiens_hsa003500.40285102
140Vitamin B6 metabolism_Homo sapiens_hsa007500.38241826
141Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37431894
142SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36538476
143Tryptophan metabolism_Homo sapiens_hsa003800.36411241
144Proteasome_Homo sapiens_hsa030500.33293774
145Selenocompound metabolism_Homo sapiens_hsa004500.33062192

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