CAV1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)7.13314572
2retina vasculature morphogenesis in camera-type eye (GO:0061299)5.96728628
3regulation of cholesterol storage (GO:0010885)5.51527498
4vascular endothelial growth factor signaling pathway (GO:0038084)4.70626535
5substrate-dependent cell migration (GO:0006929)4.54821276
6regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.47323295
7regulation of sequestering of triglyceride (GO:0010889)4.45240422
8endodermal cell differentiation (GO:0035987)4.42674541
9negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.40128753
10white fat cell differentiation (GO:0050872)4.11924773
11brown fat cell differentiation (GO:0050873)4.11598685
12regulation of vascular endothelial growth factor signaling pathway (GO:1900746)4.11136747
13barbed-end actin filament capping (GO:0051016)4.06849172
14positive regulation of macrophage cytokine production (GO:0060907)4.03776801
15cell adhesion mediated by integrin (GO:0033627)4.03299443
16apoptotic cell clearance (GO:0043277)3.97246620
17cell migration involved in heart development (GO:0060973)3.94420458
18valine metabolic process (GO:0006573)3.92515540
19triglyceride catabolic process (GO:0019433)3.92345278
20lymph vessel development (GO:0001945)3.87517974
21basement membrane organization (GO:0071711)3.85816651
22phagocytosis, recognition (GO:0006910)3.83255140
23extracellular fibril organization (GO:0043206)3.82527898
24fatty acid transmembrane transport (GO:1902001)3.82277302
25glomerular filtration (GO:0003094)3.81076633
26growth hormone receptor signaling pathway (GO:0060396)3.79695220
27blood vessel maturation (GO:0001955)3.73711469
28Golgi transport vesicle coating (GO:0048200)3.73252985
29COPI coating of Golgi vesicle (GO:0048205)3.73252985
30type B pancreatic cell proliferation (GO:0044342)3.69945806
31protein heterotrimerization (GO:0070208)3.67111311
32* membrane raft organization (GO:0031579)3.66717149
33positive regulation of blood vessel endothelial cell migration (GO:0043536)3.66528939
34negative regulation of chondrocyte differentiation (GO:0032331)3.65729810
35cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.65426604
36actin filament depolymerization (GO:0030042)3.62313038
37muscle cell migration (GO:0014812)3.61560070
38lymphangiogenesis (GO:0001946)3.61161426
39renal filtration (GO:0097205)3.59041949
40regulation of macrophage derived foam cell differentiation (GO:0010743)3.58140150
41kidney mesenchyme development (GO:0072074)3.49905658
42negative regulation of lipid storage (GO:0010888)3.49041317
43mesenchymal-epithelial cell signaling (GO:0060638)3.48377336
44sprouting angiogenesis (GO:0002040)3.47625218
45protein retention in ER lumen (GO:0006621)3.46676828
46skin morphogenesis (GO:0043589)3.46521531
47wound healing, spreading of epidermal cells (GO:0035313)3.46099335
48ovulation from ovarian follicle (GO:0001542)3.45538320
49maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.43363938
50acylglycerol catabolic process (GO:0046464)3.42867349
51neutral lipid catabolic process (GO:0046461)3.42867349
52extracellular matrix assembly (GO:0085029)3.39329083
53neuron projection extension involved in neuron projection guidance (GO:1902284)3.39156762
54axon extension involved in axon guidance (GO:0048846)3.39156762
55desmosome organization (GO:0002934)3.34581310
56regulation of vasculogenesis (GO:2001212)3.31642535
57endothelium development (GO:0003158)3.31226000
58sequestering of extracellular ligand from receptor (GO:0035581)3.29672536
59fibril organization (GO:0097435)3.28929934
60regulation of plasminogen activation (GO:0010755)3.27295166
61positive regulation of smooth muscle cell migration (GO:0014911)3.27134169
62cellular response to growth hormone stimulus (GO:0071378)3.26046111
63regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.25832455
64endothelial cell morphogenesis (GO:0001886)3.22307294
65cell migration involved in sprouting angiogenesis (GO:0002042)3.22044400
66endocardial cushion development (GO:0003197)3.20884793
67positive regulation of vasculogenesis (GO:2001214)3.19546407
68substrate adhesion-dependent cell spreading (GO:0034446)3.18612685
69regulation of tight junction assembly (GO:2000810)3.18223101
70dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.18003636
71metanephric mesenchyme development (GO:0072075)3.15894964
72stress fiber assembly (GO:0043149)3.14526892
73lipid particle organization (GO:0034389)3.13700734
74endothelial cell proliferation (GO:0001935)3.13608041
75negative regulation of fatty acid transport (GO:2000192)3.13244320
76protein localization to cell surface (GO:0034394)3.12581402
77cell-substrate adherens junction assembly (GO:0007045)3.12091597
78focal adhesion assembly (GO:0048041)3.12091597
79negative regulation of smooth muscle cell migration (GO:0014912)3.11930085
80response to gravity (GO:0009629)3.11501514
81protein hydroxylation (GO:0018126)3.09816783
82wound healing, spreading of cells (GO:0044319)3.09411396
83regulation of endothelial cell differentiation (GO:0045601)3.07963789
84regulation of macrophage cytokine production (GO:0010935)3.07269599
85positive regulation of lipid storage (GO:0010884)3.04335351
86surfactant homeostasis (GO:0043129)3.04295546
87heart trabecula formation (GO:0060347)3.04069379
88positive regulation of endothelial cell migration (GO:0010595)3.03776877
89regulation of integrin-mediated signaling pathway (GO:2001044)3.03075525
90adherens junction assembly (GO:0034333)3.03014439
91peptidyl-proline hydroxylation (GO:0019511)3.02525073
92cellular response to vitamin D (GO:0071305)3.02036917
93protein maturation by protein folding (GO:0022417)3.01420468
94hypotonic response (GO:0006971)3.01216461
95positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.00511382
96* negative regulation of endothelial cell proliferation (GO:0001937)2.96878628
97positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.91023866
98positive regulation of fatty acid oxidation (GO:0046321)2.90895872
99collagen metabolic process (GO:0032963)2.87961338
100regulation of lipid storage (GO:0010883)2.87747213
101negative regulation of cartilage development (GO:0061037)2.87722608
102regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.86968264
103positive regulation of cholesterol efflux (GO:0010875)2.86003164
104collagen fibril organization (GO:0030199)2.85545996
105positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.82458364
106regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.80868809
107positive regulation of glomerulus development (GO:0090193)2.79696185
108positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.79096956
109positive regulation of epithelial cell migration (GO:0010634)2.79072416
110negative regulation of stem cell proliferation (GO:2000647)2.78402608
111regulation of transforming growth factor beta2 production (GO:0032909)2.77179320
112positive regulation of fatty acid beta-oxidation (GO:0032000)2.76652048
113positive regulation of endothelial cell apoptotic process (GO:2000353)2.75534309
114extracellular matrix disassembly (GO:0022617)2.75305501
115positive regulation of actin filament depolymerization (GO:0030836)2.73703386
116hippo signaling (GO:0035329)2.73638686
117morphogenesis of an endothelium (GO:0003159)2.73600985
118endothelial tube morphogenesis (GO:0061154)2.73600985
119fibroblast migration (GO:0010761)2.73092419
120cardiac muscle cell proliferation (GO:0060038)2.71616147
121hemidesmosome assembly (GO:0031581)2.70870146
122extracellular matrix organization (GO:0030198)2.70738778
123extracellular structure organization (GO:0043062)2.69675409
124blood vessel endothelial cell migration (GO:0043534)2.67809632
125positive regulation of fibroblast migration (GO:0010763)2.67748140
126regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.67401452
127positive regulation of cholesterol transport (GO:0032376)2.67077269
128positive regulation of sterol transport (GO:0032373)2.67077269
129cGMP-mediated signaling (GO:0019934)2.66441801
130multicellular organismal macromolecule metabolic process (GO:0044259)2.65747312
131endothelial cell chemotaxis (GO:0035767)2.65732194
132cell-substrate junction assembly (GO:0007044)2.64098186
133positive regulation of osteoblast proliferation (GO:0033690)2.63730517
134mesodermal cell differentiation (GO:0048333)2.63675772
135* lipid storage (GO:0019915)2.62033914
136transcytosis (GO:0045056)2.61868433
137vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.61785176
138protein localization to endosome (GO:0036010)2.61528803
139protein targeting to plasma membrane (GO:0072661)2.61358099
140plasma lipoprotein particle clearance (GO:0034381)2.60703806
141regulation of smooth muscle cell migration (GO:0014910)2.59129586
142positive regulation of fatty acid metabolic process (GO:0045923)2.58818199
143collagen catabolic process (GO:0030574)2.58229111
144positive regulation of receptor recycling (GO:0001921)2.57668304
145negative regulation of protein autophosphorylation (GO:0031953)2.54759452
146plasma membrane repair (GO:0001778)2.54496493
147hyaluronan catabolic process (GO:0030214)2.54162992
148heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.54027734
149multicellular organismal metabolic process (GO:0044236)2.53828191
150chondrocyte proliferation (GO:0035988)2.53774464
151smooth muscle tissue development (GO:0048745)2.53094414
152biotin metabolic process (GO:0006768)2.51955081
153positive regulation of cartilage development (GO:0061036)2.51659939
154regulation of glomerular filtration (GO:0003093)2.51208936
155cortical actin cytoskeleton organization (GO:0030866)2.51018573
156negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.50663240
157adhesion of symbiont to host (GO:0044406)2.50375937
158platelet-derived growth factor receptor signaling pathway (GO:0048008)2.50240644
159regulation of transforming growth factor beta1 production (GO:0032908)2.48754163
160ventricular cardiac muscle cell development (GO:0055015)2.48634146
161carnitine shuttle (GO:0006853)2.47194694
162cellular response to vitamin (GO:0071295)2.46704419
163blood vessel remodeling (GO:0001974)2.45410263
164negative regulation of adherens junction organization (GO:1903392)2.45361377
165negative regulation of cell junction assembly (GO:1901889)2.45361377
166cellular response to lithium ion (GO:0071285)2.44814718
167epithelial cell-cell adhesion (GO:0090136)2.44582568
168* membrane assembly (GO:0071709)2.44276167

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.58793397
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.54649477
3TP63_17297297_ChIP-ChIP_HaCaT_Human4.07686374
4CLOCK_20551151_ChIP-Seq_293T_Human3.66369832
5RARG_19884340_ChIP-ChIP_MEFs_Mouse3.56630111
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.42360039
7GATA1_22025678_ChIP-Seq_K562_Human2.73724267
8GATA2_21666600_ChIP-Seq_HMVEC_Human2.57660039
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.46983953
10SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.31450020
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.27811650
12ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.25463294
13TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.21548843
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.21292735
15* CJUN_26792858_Chip-Seq_BT549_Human2.16498811
16SMAD_19615063_ChIP-ChIP_OVARY_Human2.15413549
17CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.10151302
18* EP300_21415370_ChIP-Seq_HL-1_Mouse2.05732557
19* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.04827469
20AR_21909140_ChIP-Seq_LNCAP_Human2.04023525
21PPAR_26484153_Chip-Seq_NCI-H1993_Human1.94812881
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85576260
23TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80757937
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.80362380
25* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.73782095
26NRF2_20460467_ChIP-Seq_MEFs_Mouse1.71400395
27NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.71400395
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.70463445
29* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.69181648
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.64221172
31ZNF263_19887448_ChIP-Seq_K562_Human1.63047354
32ESR1_20079471_ChIP-ChIP_T-47D_Human1.62567230
33TBX20_22328084_ChIP-Seq_HEART_Mouse1.62025696
34TBX20_22080862_ChIP-Seq_HEART_Mouse1.62025696
35* CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.61684145
36RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.58372702
37* ATF3_27146783_Chip-Seq_COLON_Human1.58340281
38* SOX2_20726797_ChIP-Seq_SW620_Human1.57251632
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.54296415
40KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.53281296
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.52040225
42* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.51865915
43* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.51865915
44* ELK3_25401928_ChIP-Seq_HUVEC_Human1.51505738
45BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.51263581
46* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.51015817
47* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.45523931
48* BRD4_25478319_ChIP-Seq_HGPS_Human1.45024823
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.44964262
50IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.43532359
51* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.43201533
52TP53_22127205_ChIP-Seq_IMR90_Human1.42119461
53ESR1_21235772_ChIP-Seq_MCF-7_Human1.40762139
54* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.39628904
55SALL4_18804426_ChIP-ChIP_XEN_Mouse1.38896251
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37733549
57LXR_22158963_ChIP-Seq_LIVER_Mouse1.37599528
58* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.37433046
59WT1_19549856_ChIP-ChIP_CCG9911_Human1.36524254
60* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.34565159
61EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.34551237
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.32769026
63HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.32492529
64TP53_18474530_ChIP-ChIP_U2OS_Human1.32335924
65* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.32270085
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32115412
67EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31547116
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30995400
69VDR_24787735_ChIP-Seq_THP-1_Human1.30292778
70IRF8_22096565_ChIP-ChIP_GC-B_Human1.29089297
71JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28593237
72EGR1_19374776_ChIP-ChIP_THP-1_Human1.26862606
73FOXM1_23109430_ChIP-Seq_U2OS_Human1.25960421
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25039745
75TCF4_18268006_ChIP-ChIP_LS174T_Human1.23964632
76* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.20678376
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20343172
78NFIB_24661679_ChIP-Seq_LUNG_Mouse1.19036702
79SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17732824
80P63_26484246_Chip-Seq_KERATINOCYTES_Human1.17252755
81TP53_16413492_ChIP-PET_HCT116_Human1.15787168
82TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15682220
83KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11712807
84TP53_23651856_ChIP-Seq_MEFs_Mouse1.11365928
85ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11051857
86IRF8_21731497_ChIP-ChIP_J774_Mouse1.09613315
87* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09601260
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09497498
89FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08409486
90SMC3_22415368_ChIP-Seq_MEFs_Mouse1.06888602
91* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06876400
92RXR_22158963_ChIP-Seq_LIVER_Mouse1.05918149
93* SA1_22415368_ChIP-Seq_MEFs_Mouse1.04879202
94ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.02688828
95NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02586634
96STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02121643
97ELK1_22589737_ChIP-Seq_MCF10A_Human1.00788256
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.00226865
99SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99205166
100* RXR_22108803_ChIP-Seq_LS180_Human0.99042795
101WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99027419
102MYB_21317192_ChIP-Seq_ERMYB_Mouse0.98852427
103BCAT_22108803_ChIP-Seq_LS180_Human0.96559945
104SOX17_20123909_ChIP-Seq_XEN_Mouse0.95201865
105SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.94884557
106ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94530205
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93776860
108TP63_23658742_ChIP-Seq_EP156T_Human0.93290037
109NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92311888
110P300_27058665_Chip-Seq_ZR-75-30cells_Human0.92059625
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.91461145
112IRF8_27001747_Chip-Seq_BMDM_Mouse0.88582408
113NFI_21473784_ChIP-Seq_ESCs_Mouse0.88320191
114ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88078194
115* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.88068127
116* SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.88010954
117FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87771325
118* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.85102984
119CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84401730
120RACK7_27058665_Chip-Seq_MCF-7_Human0.84033644
121SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.82907014
122TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82848347
123EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.82314984
124UBF1/2_26484160_Chip-Seq_HMECs_Human0.82230190
125MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.81633691
126FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81486425
127PPARA_22158963_ChIP-Seq_LIVER_Mouse0.81445188
128KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81279665
129KLF4_18555785_ChIP-Seq_MESCs_Mouse0.80749932
130PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.80603304
131AHR_22903824_ChIP-Seq_MCF-7_Human0.80388575
132CDX2_20551321_ChIP-Seq_CACO-2_Human0.80297152
133SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79087589
134PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78672845
135RNF2_18974828_ChIP-Seq_MESCs_Mouse0.78582532
136EZH2_18974828_ChIP-Seq_MESCs_Mouse0.78582532

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.26440606
2MP0005670_abnormal_white_adipose4.20247217
3MP0004272_abnormal_basement_membrane3.90722239
4MP0001879_abnormal_lymphatic_vessel3.89370306
5MP0010368_abnormal_lymphatic_system3.76698615
6MP0005275_abnormal_skin_tensile3.51039194
7MP0004130_abnormal_muscle_cell3.13343682
8MP0003724_increased_susceptibility_to2.82750869
9MP0005257_abnormal_intraocular_pressure2.75516022
10MP0005666_abnormal_adipose_tissue2.73813308
11MP0000013_abnormal_adipose_tissue2.64547471
12MP0003279_aneurysm2.49076025
13MP0004185_abnormal_adipocyte_glucose2.34081670
14* MP0003705_abnormal_hypodermis_morpholog2.27072927
15MP0001958_emphysema2.25169888
16MP0005167_abnormal_blood-brain_barrier2.24960627
17* MP0003828_pulmonary_edema2.24830004
18MP0005375_adipose_tissue_phenotype2.23197954
19MP0010352_gastrointestinal_tract_polyps2.19049930
20* MP0002332_abnormal_exercise_endurance2.17454796
21MP0003566_abnormal_cell_adhesion2.16459357
22* MP0003191_abnormal_cellular_cholesterol2.15982602
23MP0010030_abnormal_orbit_morphology2.10616501
24MP0003941_abnormal_skin_development1.97945168
25MP0000343_altered_response_to1.88426707
26MP0000003_abnormal_adipose_tissue1.87242694
27MP0000767_abnormal_smooth_muscle1.85270136
28MP0002837_dystrophic_cardiac_calcinosis1.79842126
29MP0000762_abnormal_tongue_morphology1.78523893
30MP0000750_abnormal_muscle_regeneration1.75562430
31* MP0006138_congestive_heart_failure1.66699240
32* MP0001542_abnormal_bone_strength1.65853712
33MP0001299_abnormal_eye_distance/1.62937697
34MP0002295_abnormal_pulmonary_circulatio1.56319606
35MP0004147_increased_porphyrin_level1.55930909
36MP0009053_abnormal_anal_canal1.52838110
37MP0002108_abnormal_muscle_morphology1.50925680
38MP0004084_abnormal_cardiac_muscle1.49462252
39* MP0001544_abnormal_cardiovascular_syste1.48892489
40* MP0005385_cardiovascular_system_phenoty1.48892489
41* MP0003091_abnormal_cell_migration1.44982027
42* MP0003950_abnormal_plasma_membrane1.44039746
43MP0009278_abnormal_bone_marrow1.43663352
44MP0008775_abnormal_heart_ventricle1.42769823
45MP0005171_absent_coat_pigmentation1.41910715
46MP0001243_abnormal_dermal_layer1.37416501
47MP0004215_abnormal_myocardial_fiber1.37236271
48MP0006054_spinal_hemorrhage1.37093121
49MP0005503_abnormal_tendon_morphology1.31971670
50* MP0009115_abnormal_fat_cell1.27510040
51* MP0002971_abnormal_brown_adipose1.26282983
52* MP0005164_abnormal_response_to1.25881011
53MP0004782_abnormal_surfactant_physiolog1.25642896
54* MP0002896_abnormal_bone_mineralization1.23513198
55MP0005623_abnormal_meninges_morphology1.23206695
56* MP0005620_abnormal_muscle_contractility1.18821498
57MP0001849_ear_inflammation1.18649746
58MP0001348_abnormal_lacrimal_gland1.18077509
59MP0002060_abnormal_skin_morphology1.15218587
60* MP0000249_abnormal_blood_vessel1.15011476
61* MP0004087_abnormal_muscle_fiber1.14536599
62* MP0002972_abnormal_cardiac_muscle1.13954595
63MP0000534_abnormal_ureter_morphology1.12959566
64MP0002877_abnormal_melanocyte_morpholog1.12611647
65MP0009250_abnormal_appendicular_skeleto1.12454716
66MP0003448_altered_tumor_morphology1.11391540
67* MP0002133_abnormal_respiratory_system1.10595108
68* MP0005388_respiratory_system_phenotype1.10595108
69MP0004233_abnormal_muscle_weight1.10460618
70MP0000467_abnormal_esophagus_morphology1.07951678
71MP0003385_abnormal_body_wall1.07027375
72* MP0005595_abnormal_vascular_smooth1.07018052
73MP0001545_abnormal_hematopoietic_system1.06926839
74MP0005397_hematopoietic_system_phenotyp1.06926839
75* MP0001533_abnormal_skeleton_physiology1.03898679
76MP0010329_abnormal_lipoprotein_level1.02922805
77MP0003567_abnormal_fetal_cardiomyocyte1.00893309
78MP0000751_myopathy1.00509552
79* MP0001614_abnormal_blood_vessel0.98149489
80* MP0005023_abnormal_wound_healing0.98103728
81MP0000733_abnormal_muscle_development0.97394191
82MP0002166_altered_tumor_susceptibility0.96292913
83MP0009764_decreased_sensitivity_to0.95403763
84MP0003300_gastrointestinal_ulcer0.95352842
85MP0005197_abnormal_uvea_morphology0.95115695
86MP0003221_abnormal_cardiomyocyte_apopto0.93995985
87MP0002234_abnormal_pharynx_morphology0.93908724
88MP0002128_abnormal_blood_circulation0.92939632
89* MP0010630_abnormal_cardiac_muscle0.92763477
90MP0005409_darkened_coat_color0.90381687
91MP0004036_abnormal_muscle_relaxation0.89980795
92* MP0005334_abnormal_fat_pad0.89695125
93MP0000858_altered_metastatic_potential0.89670387
94* MP0005330_cardiomyopathy0.89166608
95MP0003690_abnormal_glial_cell0.87961501
96MP0001177_atelectasis0.86162857
97* MP0005165_increased_susceptibility_to0.85575247
98MP0004858_abnormal_nervous_system0.85007144
99* MP0003045_fibrosis0.84794623
100MP0002925_abnormal_cardiovascular_devel0.82019478
101MP0000747_muscle_weakness0.81251914
102MP0002006_tumorigenesis0.80489615
103* MP0000759_abnormal_skeletal_muscle0.79727198
104MP0005193_abnormal_anterior_eye0.79681817
105MP0004484_altered_response_of0.78526331
106* MP0000163_abnormal_cartilage_morphology0.78461163
107MP0009384_cardiac_valve_regurgitation0.78239011
108MP0005501_abnormal_skin_physiology0.78132412
109MP0003453_abnormal_keratinocyte_physiol0.77456693
110MP0002998_abnormal_bone_remodeling0.77068044
111MP0003755_abnormal_palate_morphology0.75176132
112MP0003942_abnormal_urinary_system0.75168597
113MP0002269_muscular_atrophy0.74873766
114MP0003959_abnormal_lean_body0.74251752
115MP0002796_impaired_skin_barrier0.74217223
116MP0010771_integument_phenotype0.74026501
117MP0003186_abnormal_redox_activity0.73308881
118MP0005508_abnormal_skeleton_morphology0.72483764
119MP0000749_muscle_degeneration0.71736412
120* MP0002970_abnormal_white_adipose0.71186532
121* MP0002118_abnormal_lipid_homeostasis0.70389672
122MP0002138_abnormal_hepatobiliary_system0.69771964
123* MP0005390_skeleton_phenotype0.69559316
124MP0002177_abnormal_outer_ear0.68874399
125MP0002106_abnormal_muscle_physiology0.68465340
126MP0002933_joint_inflammation0.68186299
127* MP0002113_abnormal_skeleton_development0.67366951
128* MP0000230_abnormal_systemic_arterial0.66710613
129* MP0002168_other_aberrant_phenotype0.66703576
130* MP0001881_abnormal_mammary_gland0.66299554
131MP0002932_abnormal_joint_morphology0.66224756
132* MP0001216_abnormal_epidermal_layer0.65510462
133MP0005369_muscle_phenotype0.65043371
134MP0001915_intracranial_hemorrhage0.64705172
135* MP0000266_abnormal_heart_morphology0.64145209
136MP0002876_abnormal_thyroid_physiology0.63919963
137MP0000428_abnormal_craniofacial_morphol0.63703355
138MP0001661_extended_life_span0.63574237
139MP0010386_abnormal_urinary_bladder0.61833079
140MP0010234_abnormal_vibrissa_follicle0.61723756
141MP0002282_abnormal_trachea_morphology0.61184495

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.12071825
2Increased connective tissue (HP:0009025)4.85892629
3Cerebral aneurysm (HP:0004944)4.71410367
4Protrusio acetabuli (HP:0003179)4.54332131
5* Acanthosis nigricans (HP:0000956)4.14710632
6Spinal rigidity (HP:0003306)4.07722090
7Aortic dissection (HP:0002647)3.98457674
8Aortic aneurysm (HP:0004942)3.96973376
9Hematochezia (HP:0002573)3.82793207
10Broad metatarsal (HP:0001783)3.81168100
11Oligomenorrhea (HP:0000876)3.70796423
12Ankle contracture (HP:0006466)3.58786545
13Shallow orbits (HP:0000586)3.49168071
14Muscle fiber splitting (HP:0003555)3.46542830
15Atrophic scars (HP:0001075)3.45234155
16Type 1 muscle fiber predominance (HP:0003803)3.39227461
17Increased variability in muscle fiber diameter (HP:0003557)3.10394037
18Polycythemia (HP:0001901)3.05176903
19* Hypertriglyceridemia (HP:0002155)3.04859306
20Right ventricular cardiomyopathy (HP:0011663)3.04287254
21Difficulty running (HP:0009046)3.03899989
22Dilatation of the ascending aorta (HP:0005111)3.01682558
23Vertebral compression fractures (HP:0002953)3.00540785
24Peritonitis (HP:0002586)2.99118053
25Hyporeflexia of lower limbs (HP:0002600)2.97518670
26Follicular hyperkeratosis (HP:0007502)2.95427519
27Spondylolisthesis (HP:0003302)2.88496471
28Soft skin (HP:0000977)2.82087636
29Abnormality of dentin (HP:0010299)2.81434438
30Osteolytic defects of the hand bones (HP:0009699)2.79587468
31Osteolytic defects of the phalanges of the hand (HP:0009771)2.79587468
32Aneurysm (HP:0002617)2.76816670
33Abnormality of skeletal muscle fiber size (HP:0012084)2.76406744
34Distal lower limb muscle weakness (HP:0009053)2.70134777
35Generalized amyotrophy (HP:0003700)2.62644856
36Neonatal short-limb short stature (HP:0008921)2.57072475
37Mitral valve prolapse (HP:0001634)2.56156675
38Myocardial infarction (HP:0001658)2.54317614
39Spontaneous hematomas (HP:0007420)2.54047526
40Fragile skin (HP:0001030)2.53677289
41Natal tooth (HP:0000695)2.52363064
42Cardiovascular calcification (HP:0011915)2.51665403
43Cerebral hemorrhage (HP:0001342)2.51655725
44Popliteal pterygium (HP:0009756)2.50340385
45Mildly elevated creatine phosphokinase (HP:0008180)2.50098752
46* Lipoatrophy (HP:0100578)2.49819469
47Vascular tortuosity (HP:0004948)2.49496995
48Difficulty climbing stairs (HP:0003551)2.46776022
49Venous abnormality (HP:0002624)2.45902342
50Mitral regurgitation (HP:0001653)2.45115742
51Hemorrhage of the eye (HP:0011885)2.36517629
52Distal lower limb amyotrophy (HP:0008944)2.35407258
53Scapular winging (HP:0003691)2.34741122
54Genu recurvatum (HP:0002816)2.31599956
55Joint laxity (HP:0001388)2.30718917
56Tetraparesis (HP:0002273)2.27854240
57Aortic regurgitation (HP:0001659)2.27269550
58Pterygium (HP:0001059)2.26724282
59Bladder diverticulum (HP:0000015)2.26380430
60Facial diplegia (HP:0001349)2.26102912
61Aortic valve stenosis (HP:0001650)2.26031855
62Increased mean platelet volume (HP:0011877)2.25543094
63Amniotic constriction ring (HP:0009775)2.25141310
64Abnormality of placental membranes (HP:0011409)2.25141310
65Coronal craniosynostosis (HP:0004440)2.25061157
66Arterial tortuosity (HP:0005116)2.23063798
67Entropion (HP:0000621)2.20476673
68Hypoplasia of the iris (HP:0007676)2.20431209
69Lymphangioma (HP:0100764)2.20423017
70Pigmentary retinal degeneration (HP:0001146)2.18839541
71Myotonia (HP:0002486)2.18486358
72Insulin-resistant diabetes mellitus (HP:0000831)2.16947279
73Nemaline bodies (HP:0003798)2.16286805
74Blue sclerae (HP:0000592)2.15936631
75Abnormal delivery (HP:0001787)2.13686892
76Round ear (HP:0100830)2.12883228
77Abnormality of the nasal mucosa (HP:0000433)2.12818301
78Abnormality of the acetabulum (HP:0003170)2.12654638
79* Reduced subcutaneous adipose tissue (HP:0003758)2.11260098
80Syringomyelia (HP:0003396)2.09014400
81Spinal cord lesions (HP:0100561)2.09014400
82Wormian bones (HP:0002645)2.08664154
83Mitral stenosis (HP:0001718)2.08353522
84Ventricular tachycardia (HP:0004756)2.07640559
85Esophageal varix (HP:0002040)2.06929338
86Abnormality of the umbilical cord (HP:0010881)2.06781551
87Cervical subluxation (HP:0003308)2.06534605
88Achilles tendon contracture (HP:0001771)2.05987133
89Sudden death (HP:0001699)2.05985770
90Ileus (HP:0002595)2.05754461
91Myoglobinuria (HP:0002913)2.05590966
92Ulnar bowing (HP:0003031)2.05041614
93Atrial fibrillation (HP:0005110)2.04266361
94Venous insufficiency (HP:0005293)2.03315286
95Long toe (HP:0010511)2.03056553
96Supraventricular arrhythmia (HP:0005115)2.01695918
97Hyperextensible skin (HP:0000974)2.00243569
98Wrist flexion contracture (HP:0001239)2.00079274
99Primary atrial arrhythmia (HP:0001692)1.98883185
100Abnormality of the anterior chamber (HP:0000593)1.98151154
101Toxemia of pregnancy (HP:0100603)1.96999736
102Bowel diverticulosis (HP:0005222)1.95470277
103Hypoalphalipoproteinemia (HP:0003233)1.94697912
104Onycholysis (HP:0001806)1.93490508
105Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.93026480
106Neck muscle weakness (HP:0000467)1.92862833
107Overgrowth (HP:0001548)1.92695811
108Abnormal platelet volume (HP:0011876)1.91852721
109Hydroxyprolinuria (HP:0003080)1.91271021
110Abnormality of proline metabolism (HP:0010907)1.91271021
111Lower limb amyotrophy (HP:0007210)1.90584306
112Limb-girdle muscle weakness (HP:0003325)1.90555979
113Delayed cranial suture closure (HP:0000270)1.90528306
114Pulmonary artery stenosis (HP:0004415)1.89803526
115Complement deficiency (HP:0004431)1.88999749
116Buphthalmos (HP:0000557)1.88748560
117Joint stiffness (HP:0001387)1.88630429
118Distal upper limb amyotrophy (HP:0007149)1.87794943
119Upper limb amyotrophy (HP:0009129)1.87794943
120Decreased subcutaneous fat (HP:0001002)1.87759058
121Biconcave vertebral bodies (HP:0004586)1.87128678
122Short nail (HP:0001799)1.86580923
123Muscle stiffness (HP:0003552)1.86486264
124Microglossia (HP:0000171)1.86314299
125Bronchomalacia (HP:0002780)1.86042791
126Visceral angiomatosis (HP:0100761)1.84984184
127Abnormalities of placenta or umbilical cord (HP:0001194)1.83731573
128Delayed closure of the anterior fontanelle (HP:0001476)1.83640526
129Milia (HP:0001056)1.83336578
130* Bone cyst (HP:0012062)1.83284076
131Elbow flexion contracture (HP:0002987)1.82656462
132Slender build (HP:0001533)1.82654628
133Limb-girdle muscle atrophy (HP:0003797)1.82449230
134Interstitial pulmonary disease (HP:0006530)1.82156891
135Supraventricular tachycardia (HP:0004755)1.81782880
136Rectal prolapse (HP:0002035)1.81565419
137Delayed gross motor development (HP:0002194)1.81343661
138Neonatal death (HP:0003811)1.81079623
139Coxa vara (HP:0002812)1.80244054
140Breech presentation (HP:0001623)1.79908709
141Vascular calcification (HP:0004934)1.77747988
142Trismus (HP:0000211)1.76957521
143Protruding ear (HP:0000411)1.76236659
144Ectopia lentis (HP:0001083)1.76070300
145Knee flexion contracture (HP:0006380)1.75789572
146Eczematoid dermatitis (HP:0000976)1.75783881
147Spinal cord compression (HP:0002176)1.75604654
148Abnormal cartilage morphology (HP:0002763)1.75527643
149Wide anterior fontanel (HP:0000260)1.75466706
150Abnormality of the neuromuscular junction (HP:0003398)1.75425443
151Fatigable weakness (HP:0003473)1.75425443
152Muscular dystrophy (HP:0003560)1.75159516
153Abnormality of the Achilles tendon (HP:0005109)1.74585796
154Disproportionate tall stature (HP:0001519)1.73283339
155Mesomelia (HP:0003027)1.73198620
156Striae distensae (HP:0001065)1.71745867
157Bradycardia (HP:0001662)1.71395991
158Skin nodule (HP:0200036)1.71218123

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.92210163
2TRIB33.12283794
3TTN2.85380769
4EPHB22.69912975
5RIPK12.67067072
6EPHB12.50810701
7KDR2.48491404
8TGFBR22.45442424
9EPHA22.40556370
10NEK92.38383671
11CAMK1D2.21173651
12ERN12.10009132
13MYLK2.05377461
14MAP3K121.98129342
15MST41.98093823
16TGFBR11.94104663
17BCKDK1.89876150
18MUSK1.89778375
19FER1.88896665
20SIK11.83624451
21NTRK11.82167131
22EPHA31.82039086
23FGFR41.80680263
24FGFR31.76213386
25PDGFRA1.71618240
26MST1R1.68889717
27PTK2B1.66204855
28DDR21.57381991
29DMPK1.55674559
30PDK21.55451644
31LATS11.54539480
32ERBB41.50486632
33MAPKAPK31.50058380
34MAP3K31.47574809
35PTK61.46591959
36TRPM71.45555581
37IRAK31.37168800
38PDK41.33525744
39PDK31.33525744
40ARAF1.32122092
41LMTK21.28633094
42FLT31.28482540
43FRK1.26643727
44SCYL21.25096858
45LATS21.21449264
46NME21.18190419
47TAOK21.18011191
48CAMK1G1.16488633
49MAP2K31.15522411
50FGFR21.14753482
51PIK3CA1.11365952
52NEK11.10078725
53CDK81.06180151
54PKN21.05134332
55CSK1.04693461
56ERBB31.04374832
57ROCK21.01925078
58JAK11.00589066
59BMPR1B1.00118966
60PAK40.99685331
61MET0.98884268
62TESK10.97809143
63STK380.97268185
64BUB10.95760508
65PRKD20.94794848
66EIF2AK10.92981185
67PTK20.91862439
68PAK20.90671234
69PAK60.90304180
70LRRK20.87027711
71STK30.85707824
72PIM20.84533166
73ILK0.84253112
74TYK20.83943822
75PAK30.80243726
76MELK0.79029587
77ICK0.74612813
78TBK10.74075877
79PBK0.73951869
80CDK60.72439265
81MAP3K60.69579207
82MAP2K10.69208553
83BMX0.69049775
84MOS0.68189336
85PDGFRB0.66101194
86PRKD10.66060111
87FGFR10.65500414
88BCR0.65165117
89PRKAA20.64293041
90LIMK10.64278965
91PRKG20.64131896
92EIF2AK30.61856740
93DAPK30.61156330
94PAK10.60942622
95IGF1R0.60739713
96CDK90.60594103
97PIK3CG0.59121918
98GSK3A0.58899143
99ROCK10.58468435
100MARK30.58051095
101NUAK10.56403802
102RET0.54535781
103* INSR0.52969547
104ADRBK10.52907253
105CDC42BPA0.52515951
106JAK20.52439647
107PRKCH0.51600761
108OBSCN0.51306920
109JAK30.50639405
110ABL20.50597376
111SMG10.49681340
112PRKD30.48644445
113PHKG20.47774030
114PHKG10.47774030
115AKT30.47292835
116VRK20.47236638
117TESK20.46536970
118STK38L0.46248621
119MAP3K80.46132512
120BRSK10.46032165
121TEC0.44830321
122STK100.43118756
123CAMK2G0.42562894
124GRK70.42067756
125* SRC0.41368654
126RPS6KA20.41230631
127GRK50.38682810
128PDPK10.38074300
129CCNB10.37284922
130CAMK2D0.36170665
131MAP3K140.35492255
132AURKB0.32605166
133INSRR0.31861270
134MAPK120.31380161
135* ABL10.30744573
136BRSK20.30422544
137MAPKAPK20.29796988
138MTOR0.28714152
139PRPF4B0.28337938
140EIF2AK20.28172130
141EGFR0.26687525
142MAP3K10.23774633
143MAP3K50.22126779
144PRKCE0.21829589

Predicted pathways (KEGG)

RankGene SetZ-score
1Regulation of lipolysis in adipocytes_Homo sapiens_hsa049233.25411899
2PPAR signaling pathway_Homo sapiens_hsa033203.24773990
3ECM-receptor interaction_Homo sapiens_hsa045122.88880604
4Fatty acid biosynthesis_Homo sapiens_hsa000612.67869394
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.66874320
6Propanoate metabolism_Homo sapiens_hsa006402.58742257
7* Focal adhesion_Homo sapiens_hsa045102.44048554
8Malaria_Homo sapiens_hsa051442.05534751
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.86007788
10Fatty acid metabolism_Homo sapiens_hsa012121.85140011
11Adherens junction_Homo sapiens_hsa045201.83188102
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81341984
13Adipocytokine signaling pathway_Homo sapiens_hsa049201.80964037
14* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.79340354
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.77850716
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.74995892
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.74746904
18Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.72045985
19Dilated cardiomyopathy_Homo sapiens_hsa054141.71116002
20Glycerolipid metabolism_Homo sapiens_hsa005611.67551061
21Fatty acid degradation_Homo sapiens_hsa000711.66000943
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.59210480
23* Proteoglycans in cancer_Homo sapiens_hsa052051.58066905
24Caffeine metabolism_Homo sapiens_hsa002321.56209807
25Amoebiasis_Homo sapiens_hsa051461.51223979
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.49982005
27Small cell lung cancer_Homo sapiens_hsa052221.44733443
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.41022270
29Insulin resistance_Homo sapiens_hsa049311.40741386
30Sulfur metabolism_Homo sapiens_hsa009201.27720086
31AMPK signaling pathway_Homo sapiens_hsa041521.25542249
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.22288830
33Staphylococcus aureus infection_Homo sapiens_hsa051501.21249893
34Toxoplasmosis_Homo sapiens_hsa051451.17166977
35p53 signaling pathway_Homo sapiens_hsa041151.16855519
36Platelet activation_Homo sapiens_hsa046111.13803031
37Pentose phosphate pathway_Homo sapiens_hsa000301.13148218
38PI3K-Akt signaling pathway_Homo sapiens_hsa041511.11981313
39Rap1 signaling pathway_Homo sapiens_hsa040151.09654462
40Protein digestion and absorption_Homo sapiens_hsa049741.06268088
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05910305
42Regulation of actin cytoskeleton_Homo sapiens_hsa048101.03787163
43TGF-beta signaling pathway_Homo sapiens_hsa043501.00677865
44Thyroid cancer_Homo sapiens_hsa052161.00102603
45HIF-1 signaling pathway_Homo sapiens_hsa040660.99965484
46Proteasome_Homo sapiens_hsa030500.98492921
47Tight junction_Homo sapiens_hsa045300.97490907
48Vibrio cholerae infection_Homo sapiens_hsa051100.96661716
49Melanoma_Homo sapiens_hsa052180.96251690
50Galactose metabolism_Homo sapiens_hsa000520.95335609
51TNF signaling pathway_Homo sapiens_hsa046680.95255724
52beta-Alanine metabolism_Homo sapiens_hsa004100.94367927
53Pertussis_Homo sapiens_hsa051330.92421968
54Gap junction_Homo sapiens_hsa045400.92208313
55Phagosome_Homo sapiens_hsa041450.90820525
56Salmonella infection_Homo sapiens_hsa051320.90395854
57N-Glycan biosynthesis_Homo sapiens_hsa005100.89593575
58Fat digestion and absorption_Homo sapiens_hsa049750.88989076
59Basal cell carcinoma_Homo sapiens_hsa052170.88820145
60Complement and coagulation cascades_Homo sapiens_hsa046100.88758261
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.86804038
62Hedgehog signaling pathway_Homo sapiens_hsa043400.85899653
63* Viral myocarditis_Homo sapiens_hsa054160.84963115
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.84845798
65Carbon metabolism_Homo sapiens_hsa012000.83059474
66Renin secretion_Homo sapiens_hsa049240.82092009
67Insulin signaling pathway_Homo sapiens_hsa049100.79850107
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.79608941
69Shigellosis_Homo sapiens_hsa051310.77527519
70Glioma_Homo sapiens_hsa052140.77362635
71Osteoclast differentiation_Homo sapiens_hsa043800.76254535
72Leishmaniasis_Homo sapiens_hsa051400.74124592
73Hematopoietic cell lineage_Homo sapiens_hsa046400.72690740
74Melanogenesis_Homo sapiens_hsa049160.72068639
75Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70951019
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68662508
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67320094
78Pyruvate metabolism_Homo sapiens_hsa006200.66368985
79Folate biosynthesis_Homo sapiens_hsa007900.65329365
80Glutathione metabolism_Homo sapiens_hsa004800.64957689
81Pathways in cancer_Homo sapiens_hsa052000.64532871
82Hippo signaling pathway_Homo sapiens_hsa043900.63600123
83Legionellosis_Homo sapiens_hsa051340.63245676
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62390342
85VEGF signaling pathway_Homo sapiens_hsa043700.61823326
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.61597411
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60927667
88Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60541037
89Fatty acid elongation_Homo sapiens_hsa000620.60290008
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.60187302
91Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59875997
92Renal cell carcinoma_Homo sapiens_hsa052110.59845577
93African trypanosomiasis_Homo sapiens_hsa051430.59607280
94Ras signaling pathway_Homo sapiens_hsa040140.58980479
95Nucleotide excision repair_Homo sapiens_hsa034200.57909540
96Wnt signaling pathway_Homo sapiens_hsa043100.57213410
97Rheumatoid arthritis_Homo sapiens_hsa053230.56290048
98Vitamin B6 metabolism_Homo sapiens_hsa007500.55028012
99Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54900547
100Biosynthesis of amino acids_Homo sapiens_hsa012300.54863523
101* Endocytosis_Homo sapiens_hsa041440.52050014
102Fructose and mannose metabolism_Homo sapiens_hsa000510.50576802
103Renin-angiotensin system_Homo sapiens_hsa046140.50370555
104MicroRNAs in cancer_Homo sapiens_hsa052060.50358799
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49920476
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49364905
107Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.48012781
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.46509230
109mTOR signaling pathway_Homo sapiens_hsa041500.46117057
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45979975
111Lysosome_Homo sapiens_hsa041420.45860306
112Prostate cancer_Homo sapiens_hsa052150.45551788
113Bladder cancer_Homo sapiens_hsa052190.44223882
114Peroxisome_Homo sapiens_hsa041460.43763398
115Dorso-ventral axis formation_Homo sapiens_hsa043200.43604405
116Influenza A_Homo sapiens_hsa051640.43446969
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43148392
118Hepatitis C_Homo sapiens_hsa051600.42894417
119Pancreatic cancer_Homo sapiens_hsa052120.42646710
120Tuberculosis_Homo sapiens_hsa051520.42036741
121Phenylalanine metabolism_Homo sapiens_hsa003600.41520361
122Endometrial cancer_Homo sapiens_hsa052130.41392276
123HTLV-I infection_Homo sapiens_hsa051660.41077356
124Sulfur relay system_Homo sapiens_hsa041220.40934902
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.40212843
126Cell cycle_Homo sapiens_hsa041100.40129700
127Chronic myeloid leukemia_Homo sapiens_hsa052200.39184148
128Apoptosis_Homo sapiens_hsa042100.39114695
129Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39021099
130Axon guidance_Homo sapiens_hsa043600.38972587
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38611040
132Other glycan degradation_Homo sapiens_hsa005110.37625949
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.37055937
134Colorectal cancer_Homo sapiens_hsa052100.36551819
135Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.34989809
136Ovarian steroidogenesis_Homo sapiens_hsa049130.34576040
137Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33950556
138SNARE interactions in vesicular transport_Homo sapiens_hsa041300.33628295
139Prion diseases_Homo sapiens_hsa050200.32756319
140Sphingolipid metabolism_Homo sapiens_hsa006000.32600148
141FoxO signaling pathway_Homo sapiens_hsa040680.32501083
142Glucagon signaling pathway_Homo sapiens_hsa049220.32343095

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