CATSPER2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Catsper genes belong to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. This gene is part of a tandem repeat on chromosome 15q15; this copy of the gene is thought to be a pseudogene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-fucose metabolic process (GO:0042354)4.77619281
2L-fucose catabolic process (GO:0042355)4.77619281
3fucose catabolic process (GO:0019317)4.77619281
4behavioral response to nicotine (GO:0035095)4.67749527
5piRNA metabolic process (GO:0034587)4.37580342
6cellular ketone body metabolic process (GO:0046950)4.04286303
7DNA deamination (GO:0045006)3.98537302
8platelet dense granule organization (GO:0060155)3.68359196
9ketone body metabolic process (GO:1902224)3.57279298
10response to pheromone (GO:0019236)3.52674822
11DNA methylation involved in gamete generation (GO:0043046)3.47304482
12protein complex biogenesis (GO:0070271)3.47051134
13water-soluble vitamin biosynthetic process (GO:0042364)3.46610477
14negative regulation of telomere maintenance (GO:0032205)3.45650010
15preassembly of GPI anchor in ER membrane (GO:0016254)3.44694525
16respiratory chain complex IV assembly (GO:0008535)3.44241665
17detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.39798618
18NADH dehydrogenase complex assembly (GO:0010257)3.36904165
19mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.36904165
20mitochondrial respiratory chain complex I assembly (GO:0032981)3.36904165
21positive regulation of prostaglandin secretion (GO:0032308)3.36022077
22kynurenine metabolic process (GO:0070189)3.31270876
23indolalkylamine metabolic process (GO:0006586)3.28877029
24tryptophan catabolic process (GO:0006569)3.25093506
25indole-containing compound catabolic process (GO:0042436)3.25093506
26indolalkylamine catabolic process (GO:0046218)3.25093506
27ubiquinone biosynthetic process (GO:0006744)3.21497823
28S-adenosylmethionine metabolic process (GO:0046500)3.17997318
29axoneme assembly (GO:0035082)3.17287431
30regulation of nuclear cell cycle DNA replication (GO:0033262)3.16930092
31mannosylation (GO:0097502)3.15021979
32mitochondrial respiratory chain complex assembly (GO:0033108)3.14646651
33cytochrome complex assembly (GO:0017004)3.09666734
34RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.09096469
35protein polyglutamylation (GO:0018095)3.08538201
36detection of light stimulus involved in sensory perception (GO:0050962)3.07278620
37detection of light stimulus involved in visual perception (GO:0050908)3.07278620
38phosphatidylinositol acyl-chain remodeling (GO:0036149)3.05996416
39regulation of meiosis I (GO:0060631)3.05674512
40regulation of cilium movement (GO:0003352)3.02380208
41male meiosis I (GO:0007141)2.98936328
42tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.98309616
43RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.98309616
44phosphatidylserine acyl-chain remodeling (GO:0036150)2.97805634
45cilium morphogenesis (GO:0060271)2.94897518
46ubiquinone metabolic process (GO:0006743)2.92687832
47positive regulation of mitochondrial fission (GO:0090141)2.91126579
48positive regulation of fatty acid transport (GO:2000193)2.88821425
49protein-cofactor linkage (GO:0018065)2.87861411
50photoreceptor cell maintenance (GO:0045494)2.87495351
51L-methionine salvage (GO:0071267)2.86561983
52L-methionine biosynthetic process (GO:0071265)2.86561983
53amino acid salvage (GO:0043102)2.86561983
54nonmotile primary cilium assembly (GO:0035058)2.83679554
55base-excision repair, AP site formation (GO:0006285)2.83129641
56tryptophan metabolic process (GO:0006568)2.82862598
57protein K11-linked deubiquitination (GO:0035871)2.82111103
58iron-sulfur cluster assembly (GO:0016226)2.79026665
59metallo-sulfur cluster assembly (GO:0031163)2.79026665
60multicellular organism reproduction (GO:0032504)2.77823496
61regulation of rhodopsin mediated signaling pathway (GO:0022400)2.75136080
62peptidyl-histidine modification (GO:0018202)2.74891195
63reciprocal DNA recombination (GO:0035825)2.69375076
64reciprocal meiotic recombination (GO:0007131)2.69375076
65L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.69149293
66replication fork processing (GO:0031297)2.67532837
67male meiosis (GO:0007140)2.67045769
68negative regulation of mast cell activation (GO:0033004)2.66467961
69synapsis (GO:0007129)2.64969369
70GPI anchor metabolic process (GO:0006505)2.64812660
71rRNA catabolic process (GO:0016075)2.62703539
72nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.62646949
73positive regulation of icosanoid secretion (GO:0032305)2.61627674
74rhodopsin mediated signaling pathway (GO:0016056)2.61498883
75regulation of mitotic spindle checkpoint (GO:1903504)2.61168686
76regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.61168686
77cellular biogenic amine catabolic process (GO:0042402)2.60451612
78amine catabolic process (GO:0009310)2.60451612
79protein localization to cilium (GO:0061512)2.59928302
80protein neddylation (GO:0045116)2.59912391
81neural tube formation (GO:0001841)2.59365693
82tRNA processing (GO:0008033)2.59191564
83regulation of prostaglandin secretion (GO:0032306)2.58863493
84endoderm formation (GO:0001706)2.56652889
85recombinational repair (GO:0000725)2.56608569
86phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.55350792
87DNA double-strand break processing (GO:0000729)2.53694140
88positive regulation of defense response to virus by host (GO:0002230)2.53467055
89pyrimidine nucleobase catabolic process (GO:0006208)2.52342033
90quinone biosynthetic process (GO:1901663)2.52012897
91double-strand break repair via homologous recombination (GO:0000724)2.51911311
92regulation of telomere maintenance (GO:0032204)2.51431309
93positive regulation of organic acid transport (GO:0032892)2.49946925
94exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.49169652
95epithelial cilium movement (GO:0003351)2.46683793
96adenosine metabolic process (GO:0046085)2.44955692
97positive regulation of protein homodimerization activity (GO:0090073)2.42312424
98protein K6-linked ubiquitination (GO:0085020)2.41950997
99seminiferous tubule development (GO:0072520)2.41401680
100C-terminal protein amino acid modification (GO:0018410)2.39761627

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.13662895
2VDR_22108803_ChIP-Seq_LS180_Human2.97351599
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.79570384
4GBX2_23144817_ChIP-Seq_PC3_Human2.77154472
5HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.71718756
6IGF1R_20145208_ChIP-Seq_DFB_Human2.64025509
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.53388774
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.51034494
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.42965636
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29487407
11POU3F2_20337985_ChIP-ChIP_501MEL_Human2.26461199
12EWS_26573619_Chip-Seq_HEK293_Human2.07823085
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97918037
14CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96491665
15CTBP2_25329375_ChIP-Seq_LNCAP_Human1.95549385
16IRF1_19129219_ChIP-ChIP_H3396_Human1.94704651
17EST1_17652178_ChIP-ChIP_JURKAT_Human1.94406006
18PCGF2_27294783_Chip-Seq_ESCs_Mouse1.91696012
19P300_19829295_ChIP-Seq_ESCs_Human1.88240603
20EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.87726336
21TP53_22573176_ChIP-Seq_HFKS_Human1.86869416
22VDR_23849224_ChIP-Seq_CD4+_Human1.78696212
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76973222
24ER_23166858_ChIP-Seq_MCF-7_Human1.76781707
25ELK1_19687146_ChIP-ChIP_HELA_Human1.75080410
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.72782058
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.71682511
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.71338457
29MYC_18940864_ChIP-ChIP_HL60_Human1.69956115
30FUS_26573619_Chip-Seq_HEK293_Human1.68952065
31TAF15_26573619_Chip-Seq_HEK293_Human1.61438098
32MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.53262043
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.48871044
34SRF_21415370_ChIP-Seq_HL-1_Mouse1.48754683
35FOXA1_25329375_ChIP-Seq_VCAP_Human1.48198386
36FOXA1_27270436_Chip-Seq_PROSTATE_Human1.48198386
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47152866
38CBP_20019798_ChIP-Seq_JUKART_Human1.47152866
39AR_20517297_ChIP-Seq_VCAP_Human1.45691956
40NANOG_19829295_ChIP-Seq_ESCs_Human1.44980103
41SOX2_19829295_ChIP-Seq_ESCs_Human1.44980103
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.44397221
43BCAT_22108803_ChIP-Seq_LS180_Human1.44313056
44NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.44145673
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40474375
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.35848598
47GATA3_21878914_ChIP-Seq_MCF-7_Human1.35740287
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34934088
49GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.34821616
50AR_25329375_ChIP-Seq_VCAP_Human1.31304122
51PCGF2_27294783_Chip-Seq_NPCs_Mouse1.30476080
52HOXB7_26014856_ChIP-Seq_BT474_Human1.28907018
53SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28141376
54NCOR_22424771_ChIP-Seq_293T_Human1.27174894
55TCF4_22108803_ChIP-Seq_LS180_Human1.26875204
56ETV2_25802403_ChIP-Seq_MESCs_Mouse1.26505791
57KLF5_20875108_ChIP-Seq_MESCs_Mouse1.26434763
58STAT3_23295773_ChIP-Seq_U87_Human1.26389855
59ETS1_20019798_ChIP-Seq_JURKAT_Human1.26090324
60AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25500470
61NFE2_27457419_Chip-Seq_LIVER_Mouse1.23663388
62FOXP3_21729870_ChIP-Seq_TREG_Human1.23618075
63TCF4_23295773_ChIP-Seq_U87_Human1.23481412
64ELF1_17652178_ChIP-ChIP_JURKAT_Human1.21964066
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19832705
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.19561801
67FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19500444
68LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.16207320
69EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14673570
70SMAD4_21799915_ChIP-Seq_A2780_Human1.14377765
71IRF8_22096565_ChIP-ChIP_GC-B_Human1.13109413
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12861243
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.12471603
74AUTS2_25519132_ChIP-Seq_293T-REX_Human1.11998250
75ERA_21632823_ChIP-Seq_H3396_Human1.10688580
76BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10203613
77CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.09842197
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09496598
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09483209
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09297246
81GATA3_26560356_Chip-Seq_TH2_Human1.07959394
82PIAS1_25552417_ChIP-Seq_VCAP_Human1.06070291
83CDX2_22108803_ChIP-Seq_LS180_Human1.05861263
84PRDM14_20953172_ChIP-Seq_ESCs_Human1.05811160
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.05698532
86MYC_19829295_ChIP-Seq_ESCs_Human1.05256236
87NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.04480258
88CRX_20693478_ChIP-Seq_RETINA_Mouse1.04399162
89RUNX2_22187159_ChIP-Seq_PCA_Human1.03730647
90EZH2_22144423_ChIP-Seq_EOC_Human1.03425451
91TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03334914
92EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03267677
93P53_22387025_ChIP-Seq_ESCs_Mouse1.01597017
94FOXH1_21741376_ChIP-Seq_EPCs_Human1.01072195
95REST_21632747_ChIP-Seq_MESCs_Mouse1.00546501
96NANOG_20526341_ChIP-Seq_ESCs_Human1.00358392
97TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00285519
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00285519
99SMAD4_21741376_ChIP-Seq_EPCs_Human0.99654848
100RNF2_27304074_Chip-Seq_NSC_Mouse0.97993199

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.94432105
2MP0003195_calcinosis2.82618225
3MP0002653_abnormal_ependyma_morphology2.82298618
4MP0002102_abnormal_ear_morphology2.76299175
5MP0006072_abnormal_retinal_apoptosis2.74317272
6MP0005551_abnormal_eye_electrophysiolog2.55134661
7MP0006292_abnormal_olfactory_placode2.38141151
8MP0008872_abnormal_physiological_respon2.05031304
9MP0005084_abnormal_gallbladder_morpholo2.04848224
10MP0002876_abnormal_thyroid_physiology2.02231123
11MP0003787_abnormal_imprinting1.96674826
12MP0005645_abnormal_hypothalamus_physiol1.84981065
13MP0001984_abnormal_olfaction1.84114279
14MP0005377_hearing/vestibular/ear_phenot1.83730908
15MP0003878_abnormal_ear_physiology1.83730908
16MP0005253_abnormal_eye_physiology1.81434394
17MP0005646_abnormal_pituitary_gland1.80188724
18MP0001968_abnormal_touch/_nociception1.79367613
19MP0004147_increased_porphyrin_level1.78994303
20MP0003136_yellow_coat_color1.78515758
21MP0008875_abnormal_xenobiotic_pharmacok1.75788831
22MP0000427_abnormal_hair_cycle1.72627199
23MP0004142_abnormal_muscle_tone1.72030074
24MP0000372_irregular_coat_pigmentation1.69878057
25MP0001529_abnormal_vocalization1.68859240
26MP0002837_dystrophic_cardiac_calcinosis1.62969680
27MP0004133_heterotaxia1.56305348
28MP0002736_abnormal_nociception_after1.55667880
29MP0000569_abnormal_digit_pigmentation1.53114012
30MP0009745_abnormal_behavioral_response1.49669367
31MP0001986_abnormal_taste_sensitivity1.48585116
32MP0001501_abnormal_sleep_pattern1.44171777
33MP0002163_abnormal_gland_morphology1.43560672
34MP0006276_abnormal_autonomic_nervous1.42074604
35MP0004885_abnormal_endolymph1.41673686
36MP0003011_delayed_dark_adaptation1.40248551
37MP0001485_abnormal_pinna_reflex1.40051828
38MP0002272_abnormal_nervous_system1.39777323
39MP0009046_muscle_twitch1.38703176
40MP0004742_abnormal_vestibular_system1.37997994
41MP0003646_muscle_fatigue1.37873523
42MP0002638_abnormal_pupillary_reflex1.37108058
43MP0005174_abnormal_tail_pigmentation1.35955678
44MP0005379_endocrine/exocrine_gland_phen1.33868940
45MP0002938_white_spotting1.31933537
46MP0003880_abnormal_central_pattern1.31466948
47MP0004043_abnormal_pH_regulation1.30553959
48MP0008058_abnormal_DNA_repair1.30436248
49MP0005389_reproductive_system_phenotype1.27315750
50MP0005075_abnormal_melanosome_morpholog1.26181019
51MP0005671_abnormal_response_to1.25763992
52MP0003786_premature_aging1.25479708
53MP0001486_abnormal_startle_reflex1.24697935
54MP0001919_abnormal_reproductive_system1.20561799
55MP0008789_abnormal_olfactory_epithelium1.19677897
56MP0000631_abnormal_neuroendocrine_gland1.18373830
57MP0002095_abnormal_skin_pigmentation1.18166371
58MP0005410_abnormal_fertilization1.16625039
59MP0002160_abnormal_reproductive_system1.13103410
60MP0008995_early_reproductive_senescence1.11580926
61MP0000647_abnormal_sebaceous_gland1.10528508
62MP0002557_abnormal_social/conspecific_i1.08824057
63MP0002928_abnormal_bile_duct1.07192612
64MP0001905_abnormal_dopamine_level1.06165185
65MP0010386_abnormal_urinary_bladder1.02906171
66MP0002277_abnormal_respiratory_mucosa1.01427628
67MP0005386_behavior/neurological_phenoty1.00723931
68MP0004924_abnormal_behavior1.00723931
69MP0003718_maternal_effect0.99556970
70MP0002234_abnormal_pharynx_morphology0.98053135
71MP0003698_abnormal_male_reproductive0.96320140
72MP0002572_abnormal_emotion/affect_behav0.96299233
73MP0001929_abnormal_gametogenesis0.94783678
74MP0002210_abnormal_sex_determination0.93547484
75MP0005499_abnormal_olfactory_system0.90720681
76MP0005394_taste/olfaction_phenotype0.90720681
77MP0005332_abnormal_amino_acid0.89401915
78MP0005195_abnormal_posterior_eye0.89173268
79MP0002229_neurodegeneration0.88571667
80MP0001764_abnormal_homeostasis0.86130558
81MP0000383_abnormal_hair_follicle0.85280322
82MP0005636_abnormal_mineral_homeostasis0.83067969
83MP0006036_abnormal_mitochondrial_physio0.82275970
84MP0002064_seizures0.81977323
85MP0006054_spinal_hemorrhage0.81273055
86MP0002067_abnormal_sensory_capabilities0.81254396
87MP0003121_genomic_imprinting0.81107617
88MP0001970_abnormal_pain_threshold0.80853840
89MP0002751_abnormal_autonomic_nervous0.79058711
90MP0000653_abnormal_sex_gland0.78674050
91MP0000026_abnormal_inner_ear0.78437387
92MP0003122_maternal_imprinting0.78349120
93MP0000230_abnormal_systemic_arterial0.78267975
94MP0005167_abnormal_blood-brain_barrier0.77914988
95MP0004145_abnormal_muscle_electrophysio0.77752267
96MP0002138_abnormal_hepatobiliary_system0.77592620
97MP0001293_anophthalmia0.76323539
98MP0010329_abnormal_lipoprotein_level0.76085237
99MP0005365_abnormal_bile_salt0.75627283
100MP0000538_abnormal_urinary_bladder0.75114451

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of midbrain morphology (HP:0002418)4.10230686
2Molar tooth sign on MRI (HP:0002419)4.10230686
3Pancreatic cysts (HP:0001737)3.89161497
4Pancreatic fibrosis (HP:0100732)3.47739792
5Nephronophthisis (HP:0000090)3.45059773
6Abnormality of the renal cortex (HP:0011035)3.43416415
7True hermaphroditism (HP:0010459)3.35958471
8Congenital stationary night blindness (HP:0007642)3.10592362
9Medial flaring of the eyebrow (HP:0010747)3.08817277
10Abnormality of the renal medulla (HP:0100957)3.01977691
11Renal cortical cysts (HP:0000803)2.98358475
12Type II lissencephaly (HP:0007260)2.96151012
13Chronic hepatic failure (HP:0100626)2.85964036
14Attenuation of retinal blood vessels (HP:0007843)2.84438142
15Bile duct proliferation (HP:0001408)2.74900710
16Abnormal biliary tract physiology (HP:0012439)2.74900710
173-Methylglutaconic aciduria (HP:0003535)2.64407042
18Progressive inability to walk (HP:0002505)2.54151864
19Abolished electroretinogram (ERG) (HP:0000550)2.50108584
20Gait imbalance (HP:0002141)2.48284171
21Methylmalonic acidemia (HP:0002912)2.47419076
22Acute necrotizing encephalopathy (HP:0006965)2.47000530
23Mitochondrial inheritance (HP:0001427)2.44411144
24Thyroiditis (HP:0100646)2.44117407
25Congenital primary aphakia (HP:0007707)2.43166570
26Increased CSF lactate (HP:0002490)2.41076758
27Abnormal drinking behavior (HP:0030082)2.38168313
28Polydipsia (HP:0001959)2.38168313
29Nephrogenic diabetes insipidus (HP:0009806)2.36819665
30Cerebellar dysplasia (HP:0007033)2.35601646
31Methylmalonic aciduria (HP:0012120)2.31444690
32Acute encephalopathy (HP:0006846)2.31059304
33Polyuria (HP:0000103)2.29707913
34Tubular atrophy (HP:0000092)2.27820113
35Abnormal rod and cone electroretinograms (HP:0008323)2.24340950
36IgG deficiency (HP:0004315)2.23812108
37Hepatocellular necrosis (HP:0001404)2.21767608
38Ketosis (HP:0001946)2.21284869
39Progressive macrocephaly (HP:0004481)2.20964569
40Severe combined immunodeficiency (HP:0004430)2.20834140
41Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.20762934
42Abnormality of alanine metabolism (HP:0010916)2.20762934
43Hyperalaninemia (HP:0003348)2.20762934
44Inability to walk (HP:0002540)2.19830748
45Hepatic necrosis (HP:0002605)2.18990355
46Hypomagnesemia (HP:0002917)2.17218808
47Pendular nystagmus (HP:0012043)2.16932475
48Optic disc pallor (HP:0000543)2.16817345
49Lissencephaly (HP:0001339)2.16373649
50Hyperventilation (HP:0002883)2.16333445
51Abnormal mitochondria in muscle tissue (HP:0008316)2.14971342
52Decreased electroretinogram (ERG) amplitude (HP:0000654)2.13080044
53Cystic liver disease (HP:0006706)2.10907149
54Congenital, generalized hypertrichosis (HP:0004540)2.06957599
55Stomatitis (HP:0010280)2.06142851
56Polyphagia (HP:0002591)2.03172207
57Hyperglycinemia (HP:0002154)2.02575716
58Ketoacidosis (HP:0001993)2.01429034
59Hypoproteinemia (HP:0003075)1.99187833
60Rib fusion (HP:0000902)1.98966687
61Gaze-evoked nystagmus (HP:0000640)1.98855000
62Sclerocornea (HP:0000647)1.97834321
63Hypoplasia of the pons (HP:0012110)1.97521203
64Type I transferrin isoform profile (HP:0003642)1.96398544
65Aplasia/Hypoplasia of the tibia (HP:0005772)1.95806533
66Colon cancer (HP:0003003)1.94649523
67Abnormality of the labia minora (HP:0012880)1.94407414
68Congenital hepatic fibrosis (HP:0002612)1.94103129
69Lipid accumulation in hepatocytes (HP:0006561)1.94054135
70Occipital encephalocele (HP:0002085)1.94003818
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93509973
72Abnormal protein N-linked glycosylation (HP:0012347)1.93509973
73Abnormal protein glycosylation (HP:0012346)1.93509973
74Abnormal glycosylation (HP:0012345)1.93509973
75Stomach cancer (HP:0012126)1.93334963
76Aplasia/Hypoplasia of the tongue (HP:0010295)1.92766541
77Abnormality of the pons (HP:0007361)1.92580186
78Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.92454406
79Pachygyria (HP:0001302)1.90923218
80Hyperglycinuria (HP:0003108)1.90898695
81Hypothermia (HP:0002045)1.89354128
82Postaxial foot polydactyly (HP:0001830)1.88474825
83Genital tract atresia (HP:0001827)1.87959929
84Decreased central vision (HP:0007663)1.87680556
85Increased corneal curvature (HP:0100692)1.85158024
86Keratoconus (HP:0000563)1.85158024
87Progressive microcephaly (HP:0000253)1.82815933
88Increased serum lactate (HP:0002151)1.81712712
89Abnormal urine output (HP:0012590)1.79107237
90Retinal dysplasia (HP:0007973)1.78816211
91Aplasia/Hypoplasia of the uvula (HP:0010293)1.78503106
92Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77673524
93Aplasia/Hypoplasia of the spleen (HP:0010451)1.77003173
94Vaginal atresia (HP:0000148)1.75399755
95Agitation (HP:0000713)1.74856822
96Absent thumb (HP:0009777)1.74611508
97Absent speech (HP:0001344)1.74602007
98Male pseudohermaphroditism (HP:0000037)1.74589585
99Anencephaly (HP:0002323)1.74275635
100Lactic acidosis (HP:0003128)1.73339248

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.34790123
2MAP4K23.66998795
3ZAK2.94095398
4NUAK12.88728535
5BCKDK2.81943250
6ADRBK22.71449721
7TXK2.68489910
8WNK32.55968329
9TAOK32.24316087
10BMPR1B2.15607975
11WNK42.09587721
12MAPK132.05812725
13GRK12.00965143
14PINK11.99175234
15INSRR1.92234238
16TLK11.84831702
17MAP3K41.82650544
18MST41.69265394
19BRSK21.64885439
20TRIM281.55017669
21OXSR11.51027687
22ACVR1B1.47519978
23MAPKAPK31.27257200
24DYRK21.26912680
25CASK1.26806735
26BCR1.24207538
27STK391.22394844
28CSNK1G31.17659769
29CAMKK21.12970294
30CSNK1G21.12624831
31MAP2K71.10492367
32STK161.09239878
33TNIK1.07455420
34CSNK1G11.04503891
35PAK31.00705282
36IKBKB1.00056625
37ADRBK10.91621539
38CSNK1A1L0.90724922
39VRK10.87695386
40FLT30.87399917
41PLK20.87214016
42DAPK20.84065026
43PRKCE0.83999668
44PTK2B0.82932493
45PRKCQ0.82027950
46VRK20.80899576
47PDK20.79443100
48MKNK20.79387129
49MAP2K60.77826713
50CDK190.73408222
51ERBB30.72406105
52TEC0.72032137
53PHKG20.71029452
54PHKG10.71029452
55MAP3K140.70255804
56MARK10.69674350
57PRKCG0.69335778
58MUSK0.68302795
59PLK30.67832085
60PNCK0.66463770
61MAPKAPK50.62354134
62SRPK10.61989780
63NME10.60368181
64RPS6KA50.59770229
65NEK20.56856338
66GRK60.53794001
67EIF2AK30.53572421
68MAP2K20.52661351
69WEE10.52405831
70PKN10.50891915
71PLK40.50782472
72SYK0.49675736
73DYRK1A0.49080999
74MARK30.48663936
75PRKCI0.48337540
76MKNK10.48005955
77TNK20.46791219
78CSNK1D0.45526265
79MAP4K10.44504243
80KIT0.43265060
81TIE10.43260995
82PRKACA0.42534642
83CHUK0.42111494
84STK38L0.42081416
85IKBKE0.40601976
86CSNK1A10.40060554
87CAMK2A0.39319356
88PLK10.39278879
89KDR0.38888193
90EIF2AK20.38824077
91PIK3CA0.38154659
92PRKCA0.36748211
93CHEK20.35849677
94ATR0.34598601
95STK30.32201613
96PRKCZ0.32136191
97RPS6KA40.31618003
98IRAK10.30926866
99ATM0.30301659
100EPHA40.29775248

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047442.88101665
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.73392477
3Linoleic acid metabolism_Homo sapiens_hsa005912.63508801
4alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.63359576
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.56258120
6Butanoate metabolism_Homo sapiens_hsa006502.41955815
7Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.36215972
8Nitrogen metabolism_Homo sapiens_hsa009102.27107717
9Oxidative phosphorylation_Homo sapiens_hsa001902.22901058
10Protein export_Homo sapiens_hsa030602.13805190
11Homologous recombination_Homo sapiens_hsa034402.12838204
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.02827430
13Fanconi anemia pathway_Homo sapiens_hsa034602.02623874
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.99203414
15Ether lipid metabolism_Homo sapiens_hsa005651.98472825
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.91149410
17Propanoate metabolism_Homo sapiens_hsa006401.88493869
18RNA polymerase_Homo sapiens_hsa030201.82807181
19Parkinsons disease_Homo sapiens_hsa050121.72661140
20Selenocompound metabolism_Homo sapiens_hsa004501.71375495
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.69136065
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.66539655
23Tryptophan metabolism_Homo sapiens_hsa003801.65465944
24Caffeine metabolism_Homo sapiens_hsa002321.60723171
25Basal transcription factors_Homo sapiens_hsa030221.60255725
26Peroxisome_Homo sapiens_hsa041461.56356042
27RNA degradation_Homo sapiens_hsa030181.46990713
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46546030
29Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41208155
30Nicotine addiction_Homo sapiens_hsa050331.38613403
31Sulfur metabolism_Homo sapiens_hsa009201.37482417
32Regulation of autophagy_Homo sapiens_hsa041401.32697123
33Fatty acid elongation_Homo sapiens_hsa000621.32141270
34Primary bile acid biosynthesis_Homo sapiens_hsa001201.31982934
35Primary immunodeficiency_Homo sapiens_hsa053401.20038389
36Arachidonic acid metabolism_Homo sapiens_hsa005901.19497805
37Intestinal immune network for IgA production_Homo sapiens_hsa046721.14539608
38Proteasome_Homo sapiens_hsa030501.13971868
39Non-homologous end-joining_Homo sapiens_hsa034501.10926336
40Huntingtons disease_Homo sapiens_hsa050161.08376690
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06839776
42Sulfur relay system_Homo sapiens_hsa041221.02513782
43Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97035333
44SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94922520
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94680383
46Chemical carcinogenesis_Homo sapiens_hsa052040.94516810
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93743425
48beta-Alanine metabolism_Homo sapiens_hsa004100.93505762
49Olfactory transduction_Homo sapiens_hsa047400.91296229
50Collecting duct acid secretion_Homo sapiens_hsa049660.91076122
51Alzheimers disease_Homo sapiens_hsa050100.89776751
52Steroid hormone biosynthesis_Homo sapiens_hsa001400.88334762
53Taste transduction_Homo sapiens_hsa047420.86404864
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85257676
55Cysteine and methionine metabolism_Homo sapiens_hsa002700.84125550
56Purine metabolism_Homo sapiens_hsa002300.83850881
57Steroid biosynthesis_Homo sapiens_hsa001000.82723197
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82298875
59Pyrimidine metabolism_Homo sapiens_hsa002400.81880056
60Type I diabetes mellitus_Homo sapiens_hsa049400.81087923
61Morphine addiction_Homo sapiens_hsa050320.78677572
62Retinol metabolism_Homo sapiens_hsa008300.78023062
63Nucleotide excision repair_Homo sapiens_hsa034200.77960982
64One carbon pool by folate_Homo sapiens_hsa006700.77888582
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76974829
66Metabolic pathways_Homo sapiens_hsa011000.76212614
67Base excision repair_Homo sapiens_hsa034100.76166623
68ABC transporters_Homo sapiens_hsa020100.75803353
69Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73800017
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72240644
71Asthma_Homo sapiens_hsa053100.71159431
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69420320
73Circadian rhythm_Homo sapiens_hsa047100.67836892
74Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.64764875
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64255998
76Mismatch repair_Homo sapiens_hsa034300.62843514
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60894121
78Cardiac muscle contraction_Homo sapiens_hsa042600.60224670
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59000168
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57871880
81Graft-versus-host disease_Homo sapiens_hsa053320.57232054
82Fatty acid metabolism_Homo sapiens_hsa012120.56566281
83Fat digestion and absorption_Homo sapiens_hsa049750.55759349
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55426951
85Allograft rejection_Homo sapiens_hsa053300.54569900
86Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53553677
87Insulin secretion_Homo sapiens_hsa049110.51703934
88Autoimmune thyroid disease_Homo sapiens_hsa053200.51692089
89GABAergic synapse_Homo sapiens_hsa047270.50191369
90Vitamin digestion and absorption_Homo sapiens_hsa049770.48938063
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48246347
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47528646
93Rheumatoid arthritis_Homo sapiens_hsa053230.46304201
94RNA transport_Homo sapiens_hsa030130.44545384
95Glycerolipid metabolism_Homo sapiens_hsa005610.44314365
96Fatty acid degradation_Homo sapiens_hsa000710.41691486
97Ovarian steroidogenesis_Homo sapiens_hsa049130.39113667
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.38521557
99Serotonergic synapse_Homo sapiens_hsa047260.37719218
100Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.35189965

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