CASP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.05242169
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.50061624
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.50061624
4antigen processing and presentation of endogenous antigen (GO:0019883)5.01609808
5positive regulation of gamma-delta T cell activation (GO:0046645)4.26016001
6negative regulation of lymphocyte mediated immunity (GO:0002707)4.22256248
7negative regulation of T cell mediated immunity (GO:0002710)4.07561650
8detection of other organism (GO:0098543)4.00657201
9positive T cell selection (GO:0043368)3.91587929
10regulation of B cell receptor signaling pathway (GO:0050855)3.87560483
11macrophage activation involved in immune response (GO:0002281)3.83670880
12Arp2/3 complex-mediated actin nucleation (GO:0034314)3.82875252
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.82790848
14detection of bacterium (GO:0016045)3.80829903
15immunoglobulin mediated immune response (GO:0016064)3.80048124
16negative regulation of interleukin-12 production (GO:0032695)3.77867180
17activated T cell proliferation (GO:0050798)3.76889700
18antigen processing and presentation via MHC class Ib (GO:0002475)3.72784899
19T cell selection (GO:0045058)3.72457405
20regulation of regulatory T cell differentiation (GO:0045589)3.71599941
21regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.66656630
22negative regulation of leukocyte mediated immunity (GO:0002704)3.62262243
23positive regulation of granulocyte differentiation (GO:0030854)3.62054575
24response to type I interferon (GO:0034340)3.60535960
25cellular response to type I interferon (GO:0071357)3.58105980
26type I interferon signaling pathway (GO:0060337)3.58105980
27microglial cell activation (GO:0001774)3.56460037
28positive regulation of interferon-alpha production (GO:0032727)3.50762963
29detection of external biotic stimulus (GO:0098581)3.49862828
30regulation of T cell mediated cytotoxicity (GO:0001914)3.48835597
31thymic T cell selection (GO:0045061)3.48368148
32positive regulation of T cell mediated cytotoxicity (GO:0001916)3.46346720
33interferon-gamma production (GO:0032609)3.46142942
34detection of molecule of bacterial origin (GO:0032490)3.44228894
35leukocyte aggregation (GO:0070486)3.43865658
36regulation of tolerance induction (GO:0002643)3.42736464
37negative regulation of phagocytosis (GO:0050765)3.42196519
38neutrophil activation involved in immune response (GO:0002283)3.37162142
39regulation of interferon-alpha production (GO:0032647)3.34075093
40response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.29633738
41response to host immune response (GO:0052572)3.29633738
42regulation of interferon-beta biosynthetic process (GO:0045357)3.27821535
43regulation of gamma-delta T cell differentiation (GO:0045586)3.27374300
44negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.26981728
45positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.25991718
46positive regulation of tolerance induction (GO:0002645)3.24635173
47B cell mediated immunity (GO:0019724)3.24510932
48positive regulation of B cell differentiation (GO:0045579)3.24061486
49regulation of interleukin-12 biosynthetic process (GO:0045075)3.19391016
50leukocyte degranulation (GO:0043299)3.19039881
51regulation of natural killer cell mediated immunity (GO:0002715)3.19005432
52regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.19005432
53interferon-gamma-mediated signaling pathway (GO:0060333)3.17157339
54T cell migration (GO:0072678)3.15922282
55response to interferon-beta (GO:0035456)3.14936825
56neutrophil mediated immunity (GO:0002446)3.14299812
57negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.13673851
58regulation of B cell differentiation (GO:0045577)3.11212438
59cellular response to interferon-beta (GO:0035458)3.09457243
60dendritic cell migration (GO:0036336)3.07118117
61regulation of gamma-delta T cell activation (GO:0046643)3.06929156
62detection of biotic stimulus (GO:0009595)3.06164433
63positive regulation of mast cell activation (GO:0033005)3.05850499
64positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.05613927
65response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.05568161
66response to host (GO:0075136)3.05568161
67response to host defenses (GO:0052200)3.05568161
68response to interferon-alpha (GO:0035455)3.04397964
69cellular extravasation (GO:0045123)3.03726978
70macrophage activation (GO:0042116)3.03631659
71regulation of mast cell degranulation (GO:0043304)3.03150421
72defense response to protozoan (GO:0042832)3.02891436
73regulation of leukocyte mediated cytotoxicity (GO:0001910)3.02056320
74dendritic cell chemotaxis (GO:0002407)3.01080575
75cellular response to zinc ion (GO:0071294)3.00292670
76response to protozoan (GO:0001562)2.99690868
77regulation of mast cell activation (GO:0033003)2.98375881
78ribosomal small subunit assembly (GO:0000028)2.97189699
79negative regulation of adaptive immune response (GO:0002820)2.95852378
80T cell receptor signaling pathway (GO:0050852)2.95002609
81modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.94250542
82positive regulation by organism of defense response of other organism involved in symbiotic interact2.94250542
83modulation by symbiont of host immune response (GO:0052553)2.94250542
84positive regulation by symbiont of host defense response (GO:0052509)2.94250542
85modulation by symbiont of host defense response (GO:0052031)2.94250542
86modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.94250542
87B cell receptor signaling pathway (GO:0050853)2.93837288
88positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.92517392
89mast cell activation (GO:0045576)2.92452058
90negative regulation of T-helper cell differentiation (GO:0045623)2.91962946
91negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.91962946
92negative thymic T cell selection (GO:0045060)2.89498011
93actin nucleation (GO:0045010)2.89207724
94positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.88674190
95regulation of type I interferon-mediated signaling pathway (GO:0060338)2.88253473
96myeloid dendritic cell activation (GO:0001773)2.86987233
97response to peptidoglycan (GO:0032494)2.86583372
98regulation of response to interferon-gamma (GO:0060330)2.86261518
99NIK/NF-kappaB signaling (GO:0038061)2.85854707
100negative T cell selection (GO:0043383)2.84876742
101respiratory burst (GO:0045730)2.83968911
102regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.78639880
103positive regulation of defense response to virus by host (GO:0002230)2.75517284
104regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.73843854
105positive regulation of antigen processing and presentation (GO:0002579)2.72553831
106regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.71615902
107negative regulation of cell killing (GO:0031342)2.71162484
108negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.71162484
109response to muramyl dipeptide (GO:0032495)2.71152826
110pinocytosis (GO:0006907)2.68954315
111response to interleukin-15 (GO:0070672)2.67928115
112positive thymic T cell selection (GO:0045059)2.67439045
113neutrophil activation (GO:0042119)2.66583275
114regulation of alpha-beta T cell proliferation (GO:0046640)2.61829728
115positive regulation of interferon-beta production (GO:0032728)2.61471369
116leukocyte cell-cell adhesion (GO:0007159)2.58972584
117positive regulation of natural killer cell differentiation (GO:0032825)2.58955624
118JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.56533734
119regulation of T cell receptor signaling pathway (GO:0050856)2.55767522
120positive regulation of isotype switching (GO:0045830)2.55442637
121cellular response to exogenous dsRNA (GO:0071360)2.53732110
122regulation of RIG-I signaling pathway (GO:0039535)2.52716523
123myeloid cell activation involved in immune response (GO:0002275)2.52695117
124regulation of T cell tolerance induction (GO:0002664)2.52549211
125myeloid dendritic cell differentiation (GO:0043011)2.49273025
126regulation of antigen processing and presentation (GO:0002577)2.48159253
127granulocyte activation (GO:0036230)2.46187621
128positive regulation of alpha-beta T cell proliferation (GO:0046641)2.44859245
129polyketide metabolic process (GO:0030638)2.44133496
130doxorubicin metabolic process (GO:0044598)2.44133496
131daunorubicin metabolic process (GO:0044597)2.44133496
132tolerance induction (GO:0002507)2.42175215
133cellular response to interleukin-15 (GO:0071350)2.39643838
134lipopolysaccharide-mediated signaling pathway (GO:0031663)2.39397295
135mature B cell differentiation (GO:0002335)2.38061670
136positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.37736425
137T cell costimulation (GO:0031295)2.37715469
138positive regulation of lamellipodium assembly (GO:0010592)2.37374570
139natural killer cell mediated cytotoxicity (GO:0042267)2.37130948
140natural killer cell mediated immunity (GO:0002228)2.37130948
141cellular response to interferon-gamma (GO:0071346)2.36182619
142natural killer cell differentiation (GO:0001779)2.35564741
143production of molecular mediator involved in inflammatory response (GO:0002532)2.35405389
144negative regulation of viral genome replication (GO:0045071)2.34743708
145lymphocyte costimulation (GO:0031294)2.34666544
146antigen receptor-mediated signaling pathway (GO:0050851)2.34251049

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.00784210
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.99592593
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.16585768
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.95839191
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.93979672
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.71454831
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.37729662
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.16824167
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.12966580
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.74143472
11* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.73639150
12* IRF8_27001747_Chip-Seq_BMDM_Mouse2.65662404
13* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.65191420
14* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.63620213
15* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54872469
16* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.48059361
17SCL_19346495_ChIP-Seq_HPC-7_Human2.45815208
18* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.42435874
19* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.39846267
20* MYB_26560356_Chip-Seq_TH2_Human2.22668012
21* SPI1_23547873_ChIP-Seq_NB4_Human2.20477663
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.20276051
23MYC_22102868_ChIP-Seq_BL_Human2.14723528
24VDR_21846776_ChIP-Seq_THP-1_Human2.02189606
25* MAF_26560356_Chip-Seq_TH1_Human1.99422710
26* MYB_26560356_Chip-Seq_TH1_Human1.98236938
27* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.94885754
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.91577705
29* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.91410868
30GATA1_22025678_ChIP-Seq_K562_Human1.91202297
31* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.90823040
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89103436
33RUNX_20019798_ChIP-Seq_JUKART_Human1.88748577
34RUNX1_22412390_ChIP-Seq_EML_Mouse1.84838348
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84075985
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.83916904
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83514092
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.73945475
39VDR_24787735_ChIP-Seq_THP-1_Human1.70692432
40VDR_24763502_ChIP-Seq_THP-1_Human1.70277635
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69845135
42* SMAD_19615063_ChIP-ChIP_OVARY_Human1.69472437
43CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.65785329
44* UTX_26944678_Chip-Seq_JUKART_Human1.65337796
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.65307301
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.59542001
47FOXM1_23109430_ChIP-Seq_U2OS_Human1.52673917
48* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.52154397
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.51922494
50* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49309070
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.45719018
52* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45669388
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.45478062
54GATA2_22383799_ChIP-Seq_G1ME_Mouse1.41734874
55* RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.40107960
56STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39936329
57TCF7_22412390_ChIP-Seq_EML_Mouse1.37734047
58HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36624385
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35476610
60* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35118122
61* PU_27001747_Chip-Seq_BMDM_Mouse1.31963461
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.31657402
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30038929
64* SPI1_23127762_ChIP-Seq_K562_Human1.29489873
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.29396692
66* GATA3_27048872_Chip-Seq_THYMUS_Human1.25406095
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.24180426
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21876335
69* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.20711909
70CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.19802236
71PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19333993
72* MAF_26560356_Chip-Seq_TH2_Human1.18904370
73GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15279508
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11496547
75VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.09479750
76GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06644082
77EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04789023
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.02191526
79GATA1_19941826_ChIP-Seq_K562_Human1.01803727
80TP63_17297297_ChIP-ChIP_HaCaT_Human1.01421205
81VDR_23849224_ChIP-Seq_CD4+_Human1.00956886
82TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00631471
83* GATA3_26560356_Chip-Seq_TH2_Human0.99825272
84CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99729055
85MYC_18555785_ChIP-Seq_MESCs_Mouse0.99073757
86KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98249522
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97694617
88* FOXP3_21729870_ChIP-Seq_TREG_Human0.97180209
89KDM2B_26808549_Chip-Seq_DND41_Human0.96593652
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96541806
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95848132
92TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95226529
93SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92689927
94SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92394447
95KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.92344482
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.91159244
97* ELK1_19687146_ChIP-ChIP_HELA_Human0.90124707
98SMRT_27268052_Chip-Seq_Bcells_Human0.89726675
99GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89328853
100GATA2_21666600_ChIP-Seq_HMVEC_Human0.89173326
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89171383
102ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.88609918
103GATA2_19941826_ChIP-Seq_K562_Human0.87368248
104GATA3_26560356_Chip-Seq_TH1_Human0.87077224
105* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86151601
106E2F1_21310950_ChIP-Seq_MCF-7_Human0.86049697
107RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86013419
108FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.84812060
109PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.83570436
110* PPARA_22158963_ChIP-Seq_LIVER_Mouse0.83430490
111TFEB_21752829_ChIP-Seq_HELA_Human0.82168928
112CIITA_25753668_ChIP-Seq_RAJI_Human0.82095698
113CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.81615633
114PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81194147
115PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80572520
116GABP_17652178_ChIP-ChIP_JURKAT_Human0.79925397
117NCOR1_26117541_ChIP-Seq_K562_Human0.78995229
118BCL6_27268052_Chip-Seq_Bcells_Human0.78330497
119RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76439572
120TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76023856
121EST1_17652178_ChIP-ChIP_JURKAT_Human0.75041044
122GATA1_19941827_ChIP-Seq_MEL_Mouse0.74008434
123KDM2B_26808549_Chip-Seq_JURKAT_Human0.71860336

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.02096107
2MP0009785_altered_susceptibility_to3.10841872
3MP0005671_abnormal_response_to3.09484022
4MP0003436_decreased_susceptibility_to2.95515890
5MP0000685_abnormal_immune_system2.81894694
6MP0003724_increased_susceptibility_to2.69465562
7* MP0001800_abnormal_humoral_immune2.64232728
8MP0005000_abnormal_immune_tolerance2.62044405
9MP0005025_abnormal_response_to2.59655130
10MP0002148_abnormal_hypersensitivity_rea2.58125655
11MP0005387_immune_system_phenotype2.49526122
12MP0001790_abnormal_immune_system2.49526122
13* MP0002452_abnormal_antigen_presenting2.43797732
14MP0002166_altered_tumor_susceptibility2.42918203
15MP0003763_abnormal_thymus_physiology2.41491191
16MP0002419_abnormal_innate_immunity2.36595073
17* MP0002723_abnormal_immune_serum2.35610752
18* MP0002420_abnormal_adaptive_immunity2.29942753
19* MP0001819_abnormal_immune_cell2.29464140
20MP0006082_CNS_inflammation2.16149348
21* MP0002396_abnormal_hematopoietic_system2.13698310
22* MP0002398_abnormal_bone_marrow2.06666451
23MP0005464_abnormal_platelet_physiology2.06491510
24MP0010155_abnormal_intestine_physiology2.06449776
25MP0002006_tumorigenesis2.01807054
26MP0003303_peritoneal_inflammation1.95578002
27MP0002405_respiratory_system_inflammati1.94423584
28MP0003300_gastrointestinal_ulcer1.92623718
29MP0009333_abnormal_splenocyte_physiolog1.92207812
30* MP0000716_abnormal_immune_system1.91938920
31MP0001853_heart_inflammation1.79778757
32* MP0000689_abnormal_spleen_morphology1.75846696
33MP0001873_stomach_inflammation1.74997812
34MP0001845_abnormal_inflammatory_respons1.72732055
35* MP0002722_abnormal_immune_system1.70271068
36MP0004947_skin_inflammation1.68002335
37* MP0002429_abnormal_blood_cell1.66688385
38MP0004381_abnormal_hair_follicle1.66515991
39MP0005397_hematopoietic_system_phenotyp1.66224909
40MP0001545_abnormal_hematopoietic_system1.66224909
41MP0004808_abnormal_hematopoietic_stem1.64505048
42MP0000490_abnormal_crypts_of1.58913926
43MP0001533_abnormal_skeleton_physiology1.50155851
44MP0000858_altered_metastatic_potential1.47862840
45MP0002009_preneoplasia1.46297138
46MP0000569_abnormal_digit_pigmentation1.45246571
47MP0000465_gastrointestinal_hemorrhage1.44483870
48* MP0008469_abnormal_protein_level1.44468761
49MP0003191_abnormal_cellular_cholesterol1.42067813
50MP0006054_spinal_hemorrhage1.41575413
51MP0010352_gastrointestinal_tract_polyps1.39425573
52MP0003866_abnormal_defecation1.37872933
53MP0000703_abnormal_thymus_morphology1.33764887
54MP0003448_altered_tumor_morphology1.30297945
55MP0000343_altered_response_to1.29428433
56MP0002277_abnormal_respiratory_mucosa1.26033687
57MP0005058_abnormal_lysosome_morphology1.23571380
58MP0005075_abnormal_melanosome_morpholog1.23223385
59MP0008260_abnormal_autophagy1.20456260
60MP0004883_abnormal_blood_vessel1.20350372
61MP0005174_abnormal_tail_pigmentation1.16677394
62* MP0009764_decreased_sensitivity_to1.14186110
63MP0002138_abnormal_hepatobiliary_system1.12146355
64MP0005451_abnormal_body_composition1.12044902
65MP0005310_abnormal_salivary_gland1.10093861
66MP0009278_abnormal_bone_marrow1.09917188
67MP0002933_joint_inflammation1.07936010
68MP0008057_abnormal_DNA_replication1.07309055
69MP0005164_abnormal_response_to1.04388200
70MP0010307_abnormal_tumor_latency1.03403955
71MP0002019_abnormal_tumor_incidence1.02919212
72MP0003172_abnormal_lysosome_physiology1.02188344
73MP0004510_myositis1.00008885
74MP0005023_abnormal_wound_healing0.98333260
75MP0009763_increased_sensitivity_to0.97580994
76MP0003828_pulmonary_edema0.96813401
77MP0008007_abnormal_cellular_replicative0.96283981
78MP0003806_abnormal_nucleotide_metabolis0.93382564
79MP0002998_abnormal_bone_remodeling0.92461908
80MP0003656_abnormal_erythrocyte_physiolo0.89782519
81MP0010368_abnormal_lymphatic_system0.89428856
82MP0001851_eye_inflammation0.85283304
83MP0009840_abnormal_foam_cell0.84822764
84MP0003183_abnormal_peptide_metabolism0.83698022
85MP0003693_abnormal_embryo_hatching0.83587685
86MP0003045_fibrosis0.83457080
87MP0003186_abnormal_redox_activity0.82442086
88MP0001986_abnormal_taste_sensitivity0.82391668
89MP0003566_abnormal_cell_adhesion0.82083732
90MP0010094_abnormal_chromosome_stability0.81911475
91MP0002132_abnormal_respiratory_system0.80449217
92MP0003077_abnormal_cell_cycle0.79844673
93MP0004130_abnormal_muscle_cell0.78397850
94* MP0000249_abnormal_blood_vessel0.76978321
95MP0000609_abnormal_liver_physiology0.75781250
96MP0005390_skeleton_phenotype0.75537761
97MP0000371_diluted_coat_color0.71827384
98MP0002095_abnormal_skin_pigmentation0.71540590
99MP0004782_abnormal_surfactant_physiolog0.71342327
100MP0005166_decreased_susceptibility_to0.71143905
101MP0001663_abnormal_digestive_system0.69044740
102MP0004264_abnormal_extraembryonic_tissu0.68205966
103MP0003075_altered_response_to0.67927569
104MP0002254_reproductive_system_inflammat0.67909793
105MP0005360_urolithiasis0.67263532
106MP0000015_abnormal_ear_pigmentation0.67128272
107* MP0000598_abnormal_liver_morphology0.67127056
108MP0000477_abnormal_intestine_morphology0.66454186
109MP0001879_abnormal_lymphatic_vessel0.66330201
110MP0009765_abnormal_xenobiotic_induced0.65698642
111MP0002693_abnormal_pancreas_physiology0.64136160
112MP0003453_abnormal_keratinocyte_physiol0.63473808
113MP0002136_abnormal_kidney_physiology0.63280378
114MP0003795_abnormal_bone_structure0.63266130
115MP0003943_abnormal_hepatobiliary_system0.61682033
116MP0008961_abnormal_basal_metabolism0.60737083
117MP0005376_homeostasis/metabolism_phenot0.60678271
118MP0000604_amyloidosis0.60071978
119MP0003690_abnormal_glial_cell0.52550522
120MP0008873_increased_physiological_sensi0.51608316
121MP0001765_abnormal_ion_homeostasis0.49817741
122MP0003787_abnormal_imprinting0.49767063
123MP0004484_altered_response_of0.48642397
124MP0009115_abnormal_fat_cell0.46515205
125* MP0005319_abnormal_enzyme/_coenzyme0.45513402

Predicted human phenotypes

RankGene SetZ-score
1Elevated erythrocyte sedimentation rate (HP:0003565)4.88126110
2Recurrent abscess formation (HP:0002722)4.75139791
3Eczematoid dermatitis (HP:0000976)4.50411442
4Myositis (HP:0100614)4.42576590
5Recurrent bacterial skin infections (HP:0005406)4.25860976
6Recurrent viral infections (HP:0004429)3.77025729
7IgM deficiency (HP:0002850)3.72909649
8Recurrent fungal infections (HP:0002841)3.71785955
9Chronic otitis media (HP:0000389)3.68279373
10Keratoconjunctivitis (HP:0001096)3.58435940
11Thrombocytosis (HP:0001894)3.46997963
12Recurrent bronchitis (HP:0002837)3.44046514
13Autoimmune thrombocytopenia (HP:0001973)3.41842293
14Orchitis (HP:0100796)3.36740501
15Recurrent gram-negative bacterial infections (HP:0005420)3.28095319
16Abnormality of T cell number (HP:0011839)3.21217260
17T lymphocytopenia (HP:0005403)3.17910459
18Pustule (HP:0200039)3.17544919
19Recurrent skin infections (HP:0001581)3.17170056
20Mediastinal lymphadenopathy (HP:0100721)3.03343514
21Spontaneous hematomas (HP:0007420)2.99425553
22Nasal polyposis (HP:0100582)2.98456303
23Periodontitis (HP:0000704)2.97870143
24Recurrent cutaneous fungal infections (HP:0011370)2.96521628
25Chronic mucocutaneous candidiasis (HP:0002728)2.96521628
26Vasculitis (HP:0002633)2.95476703
27* Abnormality of T cells (HP:0002843)2.95415128
28Abnormality of the nasal mucosa (HP:0000433)2.95216329
29Combined immunodeficiency (HP:0005387)2.92956989
30Vacuolated lymphocytes (HP:0001922)2.92445528
31Meningitis (HP:0001287)2.90717189
32Abnormality of macrophages (HP:0004311)2.90048408
33Cellulitis (HP:0100658)2.89975297
34Hypochromic anemia (HP:0001931)2.85516592
35Petechiae (HP:0000967)2.85392097
36Abnormal delayed hypersensitivity skin test (HP:0002963)2.76369059
37Panhypogammaglobulinemia (HP:0003139)2.73873445
38Thyroiditis (HP:0100646)2.72957472
39* Abnormality of T cell physiology (HP:0011840)2.72100305
40Severe combined immunodeficiency (HP:0004430)2.71880189
41Hypochromic microcytic anemia (HP:0004840)2.71647073
42Anorexia (HP:0002039)2.69699115
43Eosinophilia (HP:0001880)2.68401420
44Leukocytosis (HP:0001974)2.67530594
45Optic neuritis (HP:0100653)2.66857355
46Retrobulbar optic neuritis (HP:0100654)2.66857355
47Pulmonary embolism (HP:0002204)2.65059313
48Stomach cancer (HP:0012126)2.64118197
49IgG deficiency (HP:0004315)2.62123779
50Inflammation of the large intestine (HP:0002037)2.61394332
51Abnormality of the prostate (HP:0008775)2.60919452
52B lymphocytopenia (HP:0010976)2.60513896
53Abnormality of B cell number (HP:0010975)2.60513896
54Obstructive lung disease (HP:0006536)2.60305892
55Chronic obstructive pulmonary disease (HP:0006510)2.60305892
56Lymphopenia (HP:0001888)2.60031960
57Stomatitis (HP:0010280)2.59729113
58Gangrene (HP:0100758)2.58685054
59Abnormality of cells of the lymphoid lineage (HP:0012140)2.57469165
60Gingivitis (HP:0000230)2.56601974
61Agammaglobulinemia (HP:0004432)2.56385796
62Granulocytopenia (HP:0001913)2.55737395
63Gastrointestinal inflammation (HP:0004386)2.53977845
64Abnormality of eosinophils (HP:0001879)2.51158419
65Epistaxis (HP:0000421)2.50613932
66Autoimmune hemolytic anemia (HP:0001890)2.49357974
67Hematochezia (HP:0002573)2.48344688
68Prolonged bleeding time (HP:0003010)2.44286373
69Pulmonary infiltrates (HP:0002113)2.44188398
70Interstitial pulmonary disease (HP:0006530)2.44182356
71Episodic fever (HP:0001954)2.43194935
72Gingival bleeding (HP:0000225)2.43048516
73IgA deficiency (HP:0002720)2.42621616
74Increased IgM level (HP:0003496)2.39510239
75Hemoptysis (HP:0002105)2.37348497
76Systemic lupus erythematosus (HP:0002725)2.36534483
77Osteomyelitis (HP:0002754)2.34695052
78Acute hepatic failure (HP:0006554)2.34001313
79Colitis (HP:0002583)2.32062604
80Hypergammaglobulinemia (HP:0010702)2.31064257
81Abnormal platelet function (HP:0011869)2.28881631
82Impaired platelet aggregation (HP:0003540)2.28881631
83Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.27775052
84Arterial thrombosis (HP:0004420)2.27692499
85Encephalitis (HP:0002383)2.27239269
86Hypoplasia of the thymus (HP:0000778)2.27069870
87Cheilitis (HP:0100825)2.25642736
88Basal ganglia calcification (HP:0002135)2.24929494
89Joint swelling (HP:0001386)2.16236914
90* Chronic diarrhea (HP:0002028)2.13825361
91Lymphoma (HP:0002665)2.12958968
92Keratitis (HP:0000491)2.12396889
93Peritonitis (HP:0002586)2.08912115
94Reduced antithrombin III activity (HP:0001976)2.08752807
95Verrucae (HP:0200043)2.07520352
96Papilloma (HP:0012740)2.07520352
97Chest pain (HP:0100749)2.07421970
98Skin ulcer (HP:0200042)2.07019487
99Glomerulopathy (HP:0100820)2.05477081
100Reticulocytopenia (HP:0001896)2.05442894
101Abnormality of the fingertips (HP:0001211)2.03401638
102Sepsis (HP:0100806)2.03245064
103Urticaria (HP:0001025)2.03083420
104Abnormal platelet volume (HP:0011876)1.97601530
105Prostate neoplasm (HP:0100787)1.97409124
106Neoplasm of the tracheobronchial system (HP:0100552)1.96650218
107Alveolar cell carcinoma (HP:0006519)1.96147681
108Recurrent pneumonia (HP:0006532)1.95950871
109Gastrointestinal stroma tumor (HP:0100723)1.93721197
110Microcytic anemia (HP:0001935)1.93619387
111Skin rash (HP:0000988)1.93042392
112Osteolytic defects of the phalanges of the hand (HP:0009771)1.92928607
113Osteolytic defects of the hand bones (HP:0009699)1.92928607
114Keratoconjunctivitis sicca (HP:0001097)1.92327405
115Aplastic anemia (HP:0001915)1.91636470
116Abnormality of the endocardium (HP:0004306)1.91299581
117Gastrointestinal infarctions (HP:0005244)1.91076844
118Increased IgE level (HP:0003212)1.90274753
119Vertigo (HP:0002321)1.89772299
120Polyneuropathy (HP:0001271)1.88559195
121Albinism (HP:0001022)1.88328771
122Abnormality of the pleura (HP:0002103)1.88021651
123Recurrent lower respiratory tract infections (HP:0002783)1.87535203
124Abnormality of the pericardium (HP:0001697)1.87241367
125Abnormality of iron homeostasis (HP:0011031)1.85420500

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.85019957
2ERN12.82802262
3TYK22.82143163
4TXK2.76120889
5MAP3K142.63472672
6KIT2.55407373
7BLK2.48234270
8JAK32.43587981
9TBK12.40344522
10TGFBR22.37157092
11IKBKE2.30372845
12ZAP702.21728467
13IRAK42.18939156
14TEC2.15191098
15STK102.12641922
16KDR1.97434473
17CSF1R1.87867334
18BTK1.81860695
19TNK21.80493128
20PRPF4B1.76764065
21PIM21.74735515
22JAK11.72625459
23IRAK31.65648356
24GRK61.63848603
25FLT31.59958374
26ITK1.58581590
27NME21.58549971
28IKBKB1.57008072
29FGFR41.45577643
30TAOK31.42408943
31MAP2K31.41868287
32SYK1.38479151
33FGFR31.36729232
34IRAK11.32968723
35CSK1.30126088
36BMPR21.27129411
37LCK1.24832030
38NEK91.18511226
39FGR1.17844800
40RPS6KA41.17384184
41PIM11.17053923
42ACVR1B1.14093994
43LRRK21.08381499
44PKN21.08285082
45CDK121.08270973
46CHUK1.07338500
47CAMKK21.06040345
48HCK1.05532082
49MST41.03167436
50EEF2K1.02181874
51MAP3K100.98878226
52* LYN0.97911122
53TGFBR10.97355173
54MAP3K130.96202086
55MATK0.94613617
56NLK0.94038846
57YES10.91574586
58TESK20.87196728
59MAP3K10.86483140
60EIF2AK30.84959935
61RIPK40.84365622
62STK40.83183348
63SIK20.83030408
64CLK10.81744968
65PDK10.81728098
66EIF2AK10.81248705
67JAK20.80304933
68SCYL20.77121655
69TAOK10.74532321
70EIF2AK20.73159327
71PAK40.70722224
72CDK60.70692420
73CAMKK10.69887376
74FES0.65794366
75ADRBK20.65172671
76MAP3K20.61872392
77IRAK20.61661031
78MARK20.61188875
79PIK3CG0.60683966
80MAP3K70.60428651
81TRPM70.60125751
82MARK30.60011732
83RIPK10.59984464
84PASK0.59781874
85PTK2B0.59175416
86PRKG20.58819891
87MAP3K60.56091682
88EPHB10.55655682
89MAP3K120.55555098
90MAP3K30.55119423
91RPS6KB20.54031385
92MAP3K110.53262982
93CDK40.53187447
94MAP3K80.52908161
95FRK0.52557428
96NEK20.52218365
97MAPK110.50574558
98FYN0.50388148
99CDK70.49945281
100MAPK70.49578436
101TIE10.49007595
102MAPK120.48580679
103PTK60.48502757
104EPHA30.48052589
105CDC70.47635050
106ATR0.47186861
107GRK70.47133620
108NUAK10.47099734
109BRSK20.45602462
110ABL10.45215955
111PRKCQ0.45214609
112MELK0.43112683
113MAP2K20.42712131
114PDPK10.41492155
115HIPK20.40971156
116STK380.40540234
117WNK10.40418531
118PRKCD0.39726207
119MAP2K60.39023192
120MAPK40.38388820
121ADRBK10.38357255
122GRK10.38109088
123TESK10.37752808
124MAPKAPK20.36128320
125SIK30.36011632
126STK110.35393297
127STK160.34848207
128RPS6KA60.34027927
129TLK10.33243357
130TRIB30.31767269
131IGF1R0.31737159
132AURKB0.31658764
133MAP3K50.30987776
134PRKD20.30519776
135RET0.30236195
136KSR20.30095822
137SGK20.29786692
138OXSR10.29719543
139SGK30.27895517

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.27057352
2Leishmaniasis_Homo sapiens_hsa051402.66150753
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.51012865
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.46774223
5Measles_Homo sapiens_hsa051622.33201325
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.28195883
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.27896574
8Antigen processing and presentation_Homo sapiens_hsa046122.10149681
9DNA replication_Homo sapiens_hsa030302.00795828
10Staphylococcus aureus infection_Homo sapiens_hsa051502.00786988
11Allograft rejection_Homo sapiens_hsa053301.97963205
12Hematopoietic cell lineage_Homo sapiens_hsa046401.96166832
13* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.92368277
14Osteoclast differentiation_Homo sapiens_hsa043801.91838470
15* Toll-like receptor signaling pathway_Homo sapiens_hsa046201.85032044
16* Herpes simplex infection_Homo sapiens_hsa051681.81278138
17B cell receptor signaling pathway_Homo sapiens_hsa046621.79831818
18Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.74279553
19* Legionellosis_Homo sapiens_hsa051341.62322592
20Graft-versus-host disease_Homo sapiens_hsa053321.61389655
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.60567308
22Malaria_Homo sapiens_hsa051441.56854627
23Influenza A_Homo sapiens_hsa051641.55441347
24Pertussis_Homo sapiens_hsa051331.54224792
25Other glycan degradation_Homo sapiens_hsa005111.53257689
26Caffeine metabolism_Homo sapiens_hsa002321.50752280
27Ribosome_Homo sapiens_hsa030101.48817312
28* Toxoplasmosis_Homo sapiens_hsa051451.43996135
29T cell receptor signaling pathway_Homo sapiens_hsa046601.34280995
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.33657060
31* NOD-like receptor signaling pathway_Homo sapiens_hsa046211.33081326
32Shigellosis_Homo sapiens_hsa051311.27723296
33* Apoptosis_Homo sapiens_hsa042101.26268548
34Base excision repair_Homo sapiens_hsa034101.25648792
35Leukocyte transendothelial migration_Homo sapiens_hsa046701.23041320
36Asthma_Homo sapiens_hsa053101.21106540
37* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18242926
38* TNF signaling pathway_Homo sapiens_hsa046681.17917379
39* Tuberculosis_Homo sapiens_hsa051521.15958097
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.13583616
41* Hepatitis B_Homo sapiens_hsa051611.11601198
42Mismatch repair_Homo sapiens_hsa034301.11048938
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10871586
44Non-small cell lung cancer_Homo sapiens_hsa052231.09663781
45Autoimmune thyroid disease_Homo sapiens_hsa053201.05564773
46Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04738471
47Salmonella infection_Homo sapiens_hsa051321.01332083
48Non-homologous end-joining_Homo sapiens_hsa034501.00362204
49Acute myeloid leukemia_Homo sapiens_hsa052211.00006906
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99324608
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.98364316
52Pentose and glucuronate interconversions_Homo sapiens_hsa000400.96503601
53Hepatitis C_Homo sapiens_hsa051600.94110452
54Chemokine signaling pathway_Homo sapiens_hsa040620.92495014
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.89580930
56* Viral myocarditis_Homo sapiens_hsa054160.89568352
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85629178
58Homologous recombination_Homo sapiens_hsa034400.85412128
59Small cell lung cancer_Homo sapiens_hsa052220.83295894
60Platelet activation_Homo sapiens_hsa046110.81754211
61* p53 signaling pathway_Homo sapiens_hsa041150.81608059
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80004573
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79431961
64Lysosome_Homo sapiens_hsa041420.78444176
65Chronic myeloid leukemia_Homo sapiens_hsa052200.77585552
66One carbon pool by folate_Homo sapiens_hsa006700.76428953
67Pancreatic cancer_Homo sapiens_hsa052120.76268386
68Complement and coagulation cascades_Homo sapiens_hsa046100.73673476
69Dorso-ventral axis formation_Homo sapiens_hsa043200.72670144
70Epstein-Barr virus infection_Homo sapiens_hsa051690.71809487
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.70641352
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.70168150
73HTLV-I infection_Homo sapiens_hsa051660.69585708
74FoxO signaling pathway_Homo sapiens_hsa040680.69070966
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.68825294
76Regulation of autophagy_Homo sapiens_hsa041400.68583471
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68350952
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66541150
79African trypanosomiasis_Homo sapiens_hsa051430.65784032
80* Viral carcinogenesis_Homo sapiens_hsa052030.65480663
81Pentose phosphate pathway_Homo sapiens_hsa000300.64867594
82VEGF signaling pathway_Homo sapiens_hsa043700.64358204
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60811427
84Cell cycle_Homo sapiens_hsa041100.58646647
85Pyrimidine metabolism_Homo sapiens_hsa002400.58628334
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55891708
87Galactose metabolism_Homo sapiens_hsa000520.55650455
88Nucleotide excision repair_Homo sapiens_hsa034200.55166341
89Renin-angiotensin system_Homo sapiens_hsa046140.54790484
90Inositol phosphate metabolism_Homo sapiens_hsa005620.54546412
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54357680
92Sulfur relay system_Homo sapiens_hsa041220.52597217
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.51345935
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.50703897
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.49609899
96Endocytosis_Homo sapiens_hsa041440.49413497
97Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49104986
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48680027
99Rheumatoid arthritis_Homo sapiens_hsa053230.48547062
100Thyroid cancer_Homo sapiens_hsa052160.48322172
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.48021254
102Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47663542
103Type I diabetes mellitus_Homo sapiens_hsa049400.47658471
104Renal cell carcinoma_Homo sapiens_hsa052110.46929671
105Choline metabolism in cancer_Homo sapiens_hsa052310.46838036
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46647584
107Phagosome_Homo sapiens_hsa041450.46214520
108Insulin resistance_Homo sapiens_hsa049310.45801505
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.45588811
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.44184260
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.43465669
112Folate biosynthesis_Homo sapiens_hsa007900.42877025
113Spliceosome_Homo sapiens_hsa030400.42748782
114mTOR signaling pathway_Homo sapiens_hsa041500.42390983
115Systemic lupus erythematosus_Homo sapiens_hsa053220.41260637
116Prolactin signaling pathway_Homo sapiens_hsa049170.40858509
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40760541
118Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.39734150
119ABC transporters_Homo sapiens_hsa020100.37956083
120MAPK signaling pathway_Homo sapiens_hsa040100.37067112
121Linoleic acid metabolism_Homo sapiens_hsa005910.36665211
122Colorectal cancer_Homo sapiens_hsa052100.36007372
123N-Glycan biosynthesis_Homo sapiens_hsa005100.35719429
124Proteasome_Homo sapiens_hsa030500.35615767
125RNA degradation_Homo sapiens_hsa030180.34803028
126Fanconi anemia pathway_Homo sapiens_hsa034600.34604682
127Arachidonic acid metabolism_Homo sapiens_hsa005900.34365770
128Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33137998
129HIF-1 signaling pathway_Homo sapiens_hsa040660.28951237
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27575794
131Ether lipid metabolism_Homo sapiens_hsa005650.26893189
132Endometrial cancer_Homo sapiens_hsa052130.23880908
133GnRH signaling pathway_Homo sapiens_hsa049120.22271555
134Type II diabetes mellitus_Homo sapiens_hsa049300.21351370
135Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.20082003

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