CASP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.19567393
2protein neddylation (GO:0045116)4.74544910
3DNA ligation (GO:0006266)4.61818963
4ribonucleoprotein complex disassembly (GO:0032988)4.45503840
5organelle disassembly (GO:1903008)4.39320936
6establishment of viral latency (GO:0019043)4.38667233
7ribosomal small subunit assembly (GO:0000028)4.38205634
8viral transcription (GO:0019083)4.22735438
9protein deneddylation (GO:0000338)4.22079958
10folic acid-containing compound biosynthetic process (GO:0009396)4.18164741
11translational termination (GO:0006415)4.12422235
12DNA deamination (GO:0045006)4.08503712
13proteasome assembly (GO:0043248)4.07863296
14cullin deneddylation (GO:0010388)4.07754990
15DNA strand elongation involved in DNA replication (GO:0006271)4.03715205
16ribosome assembly (GO:0042255)4.02987481
17negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.00992092
18mitotic metaphase plate congression (GO:0007080)3.95230717
19regulation of mitotic spindle checkpoint (GO:1903504)3.88841733
20regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.88841733
21protein localization to kinetochore (GO:0034501)3.87366203
22regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.85292714
23DNA strand elongation (GO:0022616)3.82193191
24negative regulation of RNA splicing (GO:0033119)3.81116834
25histone exchange (GO:0043486)3.74506836
26DNA catabolic process, exonucleolytic (GO:0000738)3.74443888
27telomere maintenance via semi-conservative replication (GO:0032201)3.70137562
28negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.69948282
29negative regulation of ligase activity (GO:0051352)3.69948282
30translational elongation (GO:0006414)3.64942437
31DNA replication initiation (GO:0006270)3.60918065
32pyrimidine nucleobase catabolic process (GO:0006208)3.60827195
33nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.60762505
34somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.60157495
35somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.60157495
36isotype switching (GO:0045190)3.60157495
37formation of translation preinitiation complex (GO:0001731)3.60150068
38regulation of protein heterodimerization activity (GO:0043497)3.58266312
39negative regulation of DNA-dependent DNA replication (GO:2000104)3.57027578
40negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.56271469
41negative regulation of DNA recombination (GO:0045910)3.56107111
42regulation of helicase activity (GO:0051095)3.54123865
43translational initiation (GO:0006413)3.51747487
44positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.51354261
45DNA topological change (GO:0006265)3.48536406
46DNA demethylation (GO:0080111)3.47351056
47negative regulation of sister chromatid segregation (GO:0033046)3.46897447
48negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.46897447
49negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.46897447
50negative regulation of mitotic sister chromatid segregation (GO:0033048)3.46897447
51negative regulation of mitotic sister chromatid separation (GO:2000816)3.46897447
52IMP metabolic process (GO:0046040)3.46603994
53mitotic recombination (GO:0006312)3.44823112
54anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.43550608
55regulation of sarcomere organization (GO:0060297)3.37360598
56protein localization to chromosome, centromeric region (GO:0071459)3.37123768
57attachment of spindle microtubules to kinetochore (GO:0008608)3.36253720
58negative regulation of chromosome segregation (GO:0051985)3.35559214
59DNA replication-dependent nucleosome organization (GO:0034723)3.35446902
60DNA replication-dependent nucleosome assembly (GO:0006335)3.35446902
61cellular protein complex disassembly (GO:0043624)3.35218791
62exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.34733317
63telomere maintenance via recombination (GO:0000722)3.34376994
64spindle checkpoint (GO:0031577)3.34037761
65viral life cycle (GO:0019058)3.32888566
66response to X-ray (GO:0010165)3.30994907
67mitotic spindle checkpoint (GO:0071174)3.30967297
68maturation of SSU-rRNA (GO:0030490)3.30551288
69nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.30225782
70metaphase plate congression (GO:0051310)3.29381220
71regulation of cellular amino acid metabolic process (GO:0006521)3.26998294
72ribosomal small subunit biogenesis (GO:0042274)3.26776627
73regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.25621992
74dosage compensation (GO:0007549)3.24315475
75SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.23556980
76DNA replication-independent nucleosome assembly (GO:0006336)3.23340178
77DNA replication-independent nucleosome organization (GO:0034724)3.23340178
78protein complex disassembly (GO:0043241)3.22854975
79mitotic nuclear envelope disassembly (GO:0007077)3.19663738
80DNA dealkylation (GO:0035510)3.19378241
81DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.17343460
82regulation of chromatin binding (GO:0035561)3.16052349
83DNA duplex unwinding (GO:0032508)3.16036763
84signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.15468156
85signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.15468156
86signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.15468156
87protein targeting to ER (GO:0045047)3.13499401
88signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.11490072
89intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.11490072
90cotranslational protein targeting to membrane (GO:0006613)3.10890731
91DNA geometric change (GO:0032392)3.09223674
92regulation of mitotic metaphase/anaphase transition (GO:0030071)3.08848491
93regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.08848491
94mitotic spindle assembly checkpoint (GO:0007094)3.08484831
95mitotic G2/M transition checkpoint (GO:0044818)3.07025389
96cell fate commitment involved in formation of primary germ layer (GO:0060795)3.06290972
97kinetochore organization (GO:0051383)3.06120374
98negative regulation of mRNA processing (GO:0050686)3.05506939
99nucleotide-excision repair, DNA gap filling (GO:0006297)3.05328628
100spindle assembly checkpoint (GO:0071173)3.05063043
101regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.04936252
102membrane disassembly (GO:0030397)3.02805716
103nuclear envelope disassembly (GO:0051081)3.02805716
104chaperone-mediated protein transport (GO:0072321)3.01942188
105regulation of telomere maintenance via telomerase (GO:0032210)3.01821983
106macromolecular complex disassembly (GO:0032984)3.01757069
107double-strand break repair via nonhomologous end joining (GO:0006303)3.00555984
108non-recombinational repair (GO:0000726)3.00555984
109signal transduction involved in cell cycle checkpoint (GO:0072395)2.99194309
110regulation of ubiquitin-protein transferase activity (GO:0051438)2.98621356
111positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.98393342
112signal transduction involved in DNA damage checkpoint (GO:0072422)2.98196972
113signal transduction involved in DNA integrity checkpoint (GO:0072401)2.98196972
114establishment of protein localization to endoplasmic reticulum (GO:0072599)2.98154432
115DNA replication checkpoint (GO:0000076)2.98082470
116termination of RNA polymerase II transcription (GO:0006369)2.97820735
117translesion synthesis (GO:0019985)2.96449288
118nuclear pore complex assembly (GO:0051292)2.96353452
119establishment of chromosome localization (GO:0051303)2.94243012
120CENP-A containing nucleosome assembly (GO:0034080)2.93751102
121cytidine metabolic process (GO:0046087)2.92750031
122cytidine catabolic process (GO:0006216)2.92750031
123cytidine deamination (GO:0009972)2.92750031
124chromatin remodeling at centromere (GO:0031055)2.92169939
125de novo protein folding (GO:0006458)2.91747363
126histone mRNA metabolic process (GO:0008334)2.91105443
127female gonad development (GO:0008585)2.91040401
128RNA-dependent DNA replication (GO:0006278)2.90377298
129RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.90223641
130alternative mRNA splicing, via spliceosome (GO:0000380)2.89693413
131regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.89265146
132regulation of sister chromatid segregation (GO:0033045)2.89229424
133regulation of mitotic sister chromatid separation (GO:0010965)2.89229424
134regulation of mitotic sister chromatid segregation (GO:0033047)2.89229424
135regulation of ligase activity (GO:0051340)2.88641196
136chromatin assembly or disassembly (GO:0006333)2.88439873
137telomere maintenance via telomere lengthening (GO:0010833)2.88409192
138positive regulation of chromosome segregation (GO:0051984)2.88273278
139nuclear-transcribed mRNA catabolic process (GO:0000956)2.87523272
140positive regulation of ligase activity (GO:0051351)2.86670957
141protein localization to endoplasmic reticulum (GO:0070972)2.86609295
142heart contraction (GO:0060047)2.86322122
143heart process (GO:0003015)2.86322122
144nuclear pore organization (GO:0006999)2.85999808
145replication fork processing (GO:0031297)2.85916598
146ATP-dependent chromatin remodeling (GO:0043044)2.83955964
147protein localization to chromosome (GO:0034502)2.82653628
148mRNA splicing, via spliceosome (GO:0000398)2.82411215
149RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.82411215
150RNA splicing, via transesterification reactions (GO:0000375)2.79886636
151nucleobase catabolic process (GO:0046113)2.79545143
152DNA double-strand break processing (GO:0000729)2.78848049
153establishment of integrated proviral latency (GO:0075713)2.78610732
154ribosomal large subunit biogenesis (GO:0042273)2.78021330
155sister chromatid segregation (GO:0000819)2.76822002
156spliceosomal snRNP assembly (GO:0000387)2.73107569
157mitotic chromosome condensation (GO:0007076)2.72275264
158mRNA catabolic process (GO:0006402)2.69322303
159regulation of histone H3-K9 methylation (GO:0051570)2.68869938
160postreplication repair (GO:0006301)2.68294685
161nucleobase biosynthetic process (GO:0046112)2.68036379
162RNA catabolic process (GO:0006401)2.67068259
163ribonucleoprotein complex biogenesis (GO:0022613)2.65439796
164negative regulation of microtubule polymerization (GO:0031115)2.64268619
165protein-DNA complex disassembly (GO:0032986)2.63850661
166nucleosome disassembly (GO:0006337)2.63850661
167chromatin assembly (GO:0031497)2.62247906
168mitotic sister chromatid cohesion (GO:0007064)2.61168954
169negative regulation of mRNA metabolic process (GO:1903312)2.60668589
170regulation of RNA export from nucleus (GO:0046831)2.59602190
171purine nucleobase biosynthetic process (GO:0009113)2.58612629
172kinetochore assembly (GO:0051382)2.58013156
173regulation of sister chromatid cohesion (GO:0007063)2.57996842
174heterochromatin organization (GO:0070828)2.57344667
175histone H2A acetylation (GO:0043968)2.57263295
176IMP biosynthetic process (GO:0006188)2.56541503
177negative regulation of histone methylation (GO:0031061)2.55480488
178viral mRNA export from host cell nucleus (GO:0046784)2.54848914
179spliceosomal complex assembly (GO:0000245)2.54716046
180antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.52653007
181antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.52653007
182maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.49993395

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.20794996
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.97729682
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.96993977
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.86037352
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.36240544
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.21055152
7MYC_19079543_ChIP-ChIP_MESCs_Mouse2.78168872
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.59900580
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.59037966
10MYC_22102868_ChIP-Seq_BL_Human2.46511035
11XRN2_22483619_ChIP-Seq_HELA_Human2.38803837
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.38700272
13ELF1_17652178_ChIP-ChIP_JURKAT_Human2.37387107
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.33333291
15NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29429978
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23837524
17VDR_22108803_ChIP-Seq_LS180_Human2.20205382
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.19846750
19ZNF274_21170338_ChIP-Seq_K562_Hela2.18180634
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.14749960
21TP63_19390658_ChIP-ChIP_HaCaT_Human2.04466888
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.01072011
23E2F7_22180533_ChIP-Seq_HELA_Human10.0384114
24ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.98335838
25FLI1_27457419_Chip-Seq_LIVER_Mouse1.96655388
26AR_21909140_ChIP-Seq_LNCAP_Human1.96614612
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95352823
28EWS_26573619_Chip-Seq_HEK293_Human1.94333365
29* VDR_23849224_ChIP-Seq_CD4+_Human1.94049210
30KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.93027863
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.90808487
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.90003500
33IGF1R_20145208_ChIP-Seq_DFB_Human1.86056402
34ELK1_19687146_ChIP-ChIP_HELA_Human1.82081354
35KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.81871651
36ETS1_20019798_ChIP-Seq_JURKAT_Human1.80434997
37* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.80356489
38TTF2_22483619_ChIP-Seq_HELA_Human1.78701579
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78356151
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.77639728
41CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77343836
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73460611
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.69665980
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69400849
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67827591
46* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66281053
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.62275895
48FOXP3_21729870_ChIP-Seq_TREG_Human1.61604776
49DCP1A_22483619_ChIP-Seq_HELA_Human1.60949448
50VDR_21846776_ChIP-Seq_THP-1_Human1.60805457
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.58792016
52KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.58792016
53KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.58792016
54IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57712484
55FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.57510196
56* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56158466
57GABP_19822575_ChIP-Seq_HepG2_Human1.55705831
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.54588132
59NANOG_16153702_ChIP-ChIP_HESCs_Human1.54041477
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.53660697
61* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.53578454
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52609228
63* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50157450
64FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47462112
65TAF15_26573619_Chip-Seq_HEK293_Human1.47189789
66FUS_26573619_Chip-Seq_HEK293_Human1.47158552
67SRF_21415370_ChIP-Seq_HL-1_Mouse1.46904050
68KDM5A_27292631_Chip-Seq_BREAST_Human1.46551329
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45940595
70CIITA_25753668_ChIP-Seq_RAJI_Human1.44761364
71JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.44020380
72NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.43136651
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39792408
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.38696424
75IRF1_19129219_ChIP-ChIP_H3396_Human1.33702242
76P300_19829295_ChIP-Seq_ESCs_Human1.33269835
77SOX2_16153702_ChIP-ChIP_HESCs_Human1.32079113
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31445357
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.29522572
80GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28298273
81ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28273024
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.26672306
83* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24468014
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.23675406
85E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23411639
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.21426602
87HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21400042
88PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20105099
89MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.20062153
90KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.16840307
91SPI1_23547873_ChIP-Seq_NB4_Human1.14902560
92ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14833124
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.14384525
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14039456
95KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13794845
96THAP11_20581084_ChIP-Seq_MESCs_Mouse1.13750108
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13136803
98NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11797968
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11612729
100PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10510178
101MAF_26560356_Chip-Seq_TH1_Human1.10068310
102WT1_19549856_ChIP-ChIP_CCG9911_Human1.09990684
103* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.08023123
104* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.07578207
105MYB_26560356_Chip-Seq_TH2_Human1.07370770
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06493024
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05375153
108TCF7_22412390_ChIP-Seq_EML_Mouse1.03672390
109CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03184615
110DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02981438
111* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.01856631
112EZH2_27294783_Chip-Seq_NPCs_Mouse1.01634330
113ZNF263_19887448_ChIP-Seq_K562_Human1.00804713
114CHD1_26751641_Chip-Seq_LNCaP_Human1.00076371
115UTX_26944678_Chip-Seq_JUKART_Human0.98617689
116NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97091033
117BP1_19119308_ChIP-ChIP_Hs578T_Human0.95811021
118CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95502981
119STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95426759
120MYC_18940864_ChIP-ChIP_HL60_Human0.95403320
121OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94524563
122PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94345494
123NOTCH1_21737748_ChIP-Seq_TLL_Human0.94302768
124SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93849129
125* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93712713
126FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93335732
127ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92917513
128IRF8_22096565_ChIP-ChIP_GC-B_Human0.92810045
129* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92313407
130CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92290937
131NFE2_27457419_Chip-Seq_LIVER_Mouse0.91740379
132RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.91550799
133* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91513673
134GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90125577
135* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.89979688
136GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89221179
137* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89215778
138MYB_26560356_Chip-Seq_TH1_Human0.88979978
139KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.88779654
140POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.88308485
141SCL_19346495_ChIP-Seq_HPC-7_Human0.87828766
142RUNX1_22412390_ChIP-Seq_EML_Mouse0.87632740
143* NANOG_21062744_ChIP-ChIP_HESCs_Human0.87188616
144SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85717874

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008877_abnormal_DNA_methylation3.56108916
2MP0003693_abnormal_embryo_hatching3.55537809
3MP0003950_abnormal_plasma_membrane3.38338847
4MP0010094_abnormal_chromosome_stability3.35878821
5MP0001188_hyperpigmentation3.15234976
6MP0001529_abnormal_vocalization3.03425342
7MP0003941_abnormal_skin_development3.02903137
8MP0004957_abnormal_blastocyst_morpholog2.94105427
9MP0003111_abnormal_nucleus_morphology2.93750760
10MP0008057_abnormal_DNA_replication2.90495238
11MP0003077_abnormal_cell_cycle2.86879206
12MP0010352_gastrointestinal_tract_polyps2.84395243
13MP0000537_abnormal_urethra_morphology2.72613266
14MP0002396_abnormal_hematopoietic_system2.46450644
15MP0008007_abnormal_cellular_replicative2.45264589
16MP0003718_maternal_effect2.28936472
17MP0000490_abnormal_crypts_of2.23235965
18MP0008058_abnormal_DNA_repair2.22841460
19MP0001348_abnormal_lacrimal_gland2.14744684
20MP0009697_abnormal_copulation2.04104584
21MP0002138_abnormal_hepatobiliary_system2.02726590
22MP0000569_abnormal_digit_pigmentation1.98489993
23MP0006054_spinal_hemorrhage1.95235652
24* MP0000350_abnormal_cell_proliferation1.94285171
25MP0001835_abnormal_antigen_presentation1.85369988
26MP0000749_muscle_degeneration1.84182827
27MP0005076_abnormal_cell_differentiation1.81022648
28MP0008932_abnormal_embryonic_tissue1.79953608
29MP0009053_abnormal_anal_canal1.78899092
30MP0003786_premature_aging1.76947870
31MP0010307_abnormal_tumor_latency1.75805897
32MP0001730_embryonic_growth_arrest1.73244653
33MP0009333_abnormal_splenocyte_physiolog1.72346136
34MP0003890_abnormal_embryonic-extraembry1.69868516
35MP0006035_abnormal_mitochondrial_morpho1.69360605
36MP0005084_abnormal_gallbladder_morpholo1.66835992
37MP0003806_abnormal_nucleotide_metabolis1.65602542
38MP0001545_abnormal_hematopoietic_system1.62902861
39MP0005397_hematopoietic_system_phenotyp1.62902861
40* MP0002398_abnormal_bone_marrow1.62793219
41MP0010234_abnormal_vibrissa_follicle1.58840310
42MP0004808_abnormal_hematopoietic_stem1.56762410
43MP0006276_abnormal_autonomic_nervous1.53898985
44MP0005174_abnormal_tail_pigmentation1.53496238
45MP0000685_abnormal_immune_system1.48189225
46MP0002254_reproductive_system_inflammat1.45286832
47* MP0000703_abnormal_thymus_morphology1.37962014
48MP0005671_abnormal_response_to1.37186677
49MP0002166_altered_tumor_susceptibility1.34546857
50MP0002019_abnormal_tumor_incidence1.34442249
51MP0003186_abnormal_redox_activity1.33118794
52MP0003567_abnormal_fetal_cardiomyocyte1.32552717
53* MP0000313_abnormal_cell_death1.32254008
54MP0003656_abnormal_erythrocyte_physiolo1.29596240
55MP0002132_abnormal_respiratory_system1.29457639
56MP0001697_abnormal_embryo_size1.28454175
57MP0002877_abnormal_melanocyte_morpholog1.28222711
58MP0005380_embryogenesis_phenotype1.28003621
59MP0001672_abnormal_embryogenesis/_devel1.28003621
60MP0006036_abnormal_mitochondrial_physio1.27675688
61* MP0003763_abnormal_thymus_physiology1.26935042
62MP0002722_abnormal_immune_system1.26722063
63* MP0002080_prenatal_lethality1.24843024
64MP0002822_catalepsy1.22634173
65MP0000358_abnormal_cell_content/1.21473469
66MP0003984_embryonic_growth_retardation1.20892272
67MP0002938_white_spotting1.20542167
68MP0001800_abnormal_humoral_immune1.20402443
69MP0002084_abnormal_developmental_patter1.20332291
70MP0002085_abnormal_embryonic_tissue1.20004673
71MP0002088_abnormal_embryonic_growth/wei1.19311788
72MP0002086_abnormal_extraembryonic_tissu1.19155592
73* MP0002429_abnormal_blood_cell1.19144211
74MP0004197_abnormal_fetal_growth/weight/1.18488759
75* MP0000716_abnormal_immune_system1.16362078
76* MP0001819_abnormal_immune_cell1.15761173
77* MP0002420_abnormal_adaptive_immunity1.14111721
78MP0000372_irregular_coat_pigmentation1.14012280
79MP0009379_abnormal_foot_pigmentation1.12717565
80MP0003705_abnormal_hypodermis_morpholog1.12713368
81MP0004084_abnormal_cardiac_muscle1.12393609
82MP0003880_abnormal_central_pattern1.12284873
83MP0000858_altered_metastatic_potential1.12193490
84MP0009765_abnormal_xenobiotic_induced1.12115134
85MP0002006_tumorigenesis1.10255044
86MP0003315_abnormal_perineum_morphology1.10219114
87* MP0002452_abnormal_antigen_presenting1.09732984
88MP0000689_abnormal_spleen_morphology1.08344509
89MP0003436_decreased_susceptibility_to1.07780670
90MP0003121_genomic_imprinting1.07433986
91MP0009278_abnormal_bone_marrow1.05547473
92MP0009785_altered_susceptibility_to1.04850807
93MP0005187_abnormal_penis_morphology1.04486572
94MP0001984_abnormal_olfaction1.03200143
95MP0000477_abnormal_intestine_morphology1.01876253
96MP0008872_abnormal_physiological_respon1.01598911
97MP0000516_abnormal_urinary_system1.01104463
98MP0005367_renal/urinary_system_phenotyp1.01104463
99MP0004215_abnormal_myocardial_fiber1.00611787
100* MP0008789_abnormal_olfactory_epithelium1.00306191
101* MP0001293_anophthalmia0.97287692
102MP0004147_increased_porphyrin_level0.95838885
103MP0004133_heterotaxia0.95651290
104MP0003221_abnormal_cardiomyocyte_apopto0.95578339
105MP0010155_abnormal_intestine_physiology0.94594901
106MP0006292_abnormal_olfactory_placode0.93322263
107MP0001873_stomach_inflammation0.93234127
108MP0001849_ear_inflammation0.93140296
109MP0002723_abnormal_immune_serum0.91455072
110MP0003303_peritoneal_inflammation0.91316934
111* MP0003861_abnormal_nervous_system0.91248471
112MP0005025_abnormal_response_to0.91187930
113MP0000778_abnormal_nervous_system0.90435475
114MP0002405_respiratory_system_inflammati0.90336395
115MP0001915_intracranial_hemorrhage0.90013299
116* MP0005499_abnormal_olfactory_system0.89415249
117* MP0005394_taste/olfaction_phenotype0.89415249
118MP0002163_abnormal_gland_morphology0.88320313
119MP0002148_abnormal_hypersensitivity_rea0.88043462
120MP0005000_abnormal_immune_tolerance0.85548329
121* MP0002092_abnormal_eye_morphology0.83440016
122MP0002736_abnormal_nociception_after0.83405420
123MP0003300_gastrointestinal_ulcer0.82706321
124MP0003448_altered_tumor_morphology0.82489660
125MP0003119_abnormal_digestive_system0.82399125
126MP0000647_abnormal_sebaceous_gland0.79959078
127MP0009703_decreased_birth_body0.79487902
128MP0001853_heart_inflammation0.79254348
129MP0006072_abnormal_retinal_apoptosis0.78580727
130MP0009672_abnormal_birth_weight0.78385674
131MP0005464_abnormal_platelet_physiology0.78231948
132MP0008770_decreased_survivor_rate0.77453844
133MP0005395_other_phenotype0.77394547
134MP0003123_paternal_imprinting0.77368547
135MP0002751_abnormal_autonomic_nervous0.76992157
136MP0002095_abnormal_skin_pigmentation0.75983039
137* MP0002102_abnormal_ear_morphology0.75668499
138MP0008004_abnormal_stomach_pH0.75519985
139MP0000465_gastrointestinal_hemorrhage0.74998143
140* MP0001286_abnormal_eye_development0.74895298
141MP0003787_abnormal_imprinting0.74799370
142* MP0001119_abnormal_female_reproductive0.74308040
143MP0005384_cellular_phenotype0.71399256
144MP0002090_abnormal_vision0.70707474
145MP0001929_abnormal_gametogenesis0.70530963
146MP0001764_abnormal_homeostasis0.69790106
147MP0003011_delayed_dark_adaptation0.68660444
148MP0005623_abnormal_meninges_morphology0.66750591
149MP0009763_increased_sensitivity_to0.64541858
150MP0002210_abnormal_sex_determination0.63758581
151MP0001177_atelectasis0.62751978

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.20242321
2Abnormality of cells of the erythroid lineage (HP:0012130)4.18430709
3Abnormal number of erythroid precursors (HP:0012131)4.00436306
4Reticulocytopenia (HP:0001896)3.69687807
5Abnormality of the heme biosynthetic pathway (HP:0010472)3.67543217
6Exercise-induced muscle cramps (HP:0003710)3.45976222
7Colon cancer (HP:0003003)3.40002683
8Birth length less than 3rd percentile (HP:0003561)3.36203146
9Increased serum pyruvate (HP:0003542)3.31519359
10Type 2 muscle fiber atrophy (HP:0003554)3.26079324
11Abnormality of glycolysis (HP:0004366)2.99339707
12Volvulus (HP:0002580)2.98791230
13Amniotic constriction ring (HP:0009775)2.96527903
14Abnormality of placental membranes (HP:0011409)2.96527903
15Abnormal lung lobation (HP:0002101)2.94713162
16Short 4th metacarpal (HP:0010044)2.91438967
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.91438967
18Patellar aplasia (HP:0006443)2.90453747
19Cortical dysplasia (HP:0002539)2.89183743
20Pallor (HP:0000980)2.86719485
21Carpal bone hypoplasia (HP:0001498)2.78052160
22Aplasia/Hypoplasia of the patella (HP:0006498)2.75530291
23Medulloblastoma (HP:0002885)2.73099626
24Abnormal hair whorl (HP:0010721)2.72966769
25Muscle fiber atrophy (HP:0100295)2.71354886
26Calf muscle hypertrophy (HP:0008981)2.70261549
27Abnormality of B cell number (HP:0010975)2.67067308
28Renal cortical cysts (HP:0000803)2.64955079
29Hyperglycinemia (HP:0002154)2.64392714
30Proximal placement of thumb (HP:0009623)2.63884744
31Increased nuchal translucency (HP:0010880)2.59240982
32Stenosis of the external auditory canal (HP:0000402)2.57316190
33Atrophy/Degeneration involving motor neurons (HP:0007373)2.57026902
34Deviation of the thumb (HP:0009603)2.55418263
35Cutaneous melanoma (HP:0012056)2.54313289
36B lymphocytopenia (HP:0010976)2.52402344
37IgM deficiency (HP:0002850)2.52076178
38Methylmalonic acidemia (HP:0002912)2.51147761
39Combined immunodeficiency (HP:0005387)2.48319214
40Poor suck (HP:0002033)2.47620106
41Thrombocytosis (HP:0001894)2.46356138
42Nephroblastoma (Wilms tumor) (HP:0002667)2.45859717
43Abnormality of serum amino acid levels (HP:0003112)2.44912467
44Amyotrophic lateral sclerosis (HP:0007354)2.44628595
45Pelvic girdle muscle weakness (HP:0003749)2.40493309
46Embryonal renal neoplasm (HP:0011794)2.39174325
47Facial hemangioma (HP:0000329)2.34207281
48Abnormality of aspartate family amino acid metabolism (HP:0010899)2.34003063
49Meckel diverticulum (HP:0002245)2.33701823
50Ependymoma (HP:0002888)2.33419458
51Hyperacusis (HP:0010780)2.32690160
52Cutis marmorata (HP:0000965)2.32116943
53Abnormality of the astrocytes (HP:0100707)2.31379915
54Astrocytoma (HP:0009592)2.31379915
55Neoplasm of the adrenal gland (HP:0100631)2.30986061
56Abnormality of the anterior horn cell (HP:0006802)2.30458201
57Degeneration of anterior horn cells (HP:0002398)2.30458201
58Increased density of long bones (HP:0006392)2.30451998
59Posterior subcapsular cataract (HP:0007787)2.29887943
60Basal cell carcinoma (HP:0002671)2.27818589
61Subacute progressive viral hepatitis (HP:0006572)2.25843087
62Disinhibition (HP:0000734)2.24819093
63Selective tooth agenesis (HP:0001592)2.24766238
64Muscle hypertrophy of the lower extremities (HP:0008968)2.23521334
65Atresia of the external auditory canal (HP:0000413)2.23274181
66Abnormal number of incisors (HP:0011064)2.23108151
67Supernumerary spleens (HP:0009799)2.22176310
68Myelodysplasia (HP:0002863)2.21288995
69Oral leukoplakia (HP:0002745)2.21262542
70Abnormality of methionine metabolism (HP:0010901)2.20633294
71Abnormality of the clitoris (HP:0000056)2.18706721
72Squamous cell carcinoma (HP:0002860)2.15444651
73Methylmalonic aciduria (HP:0012120)2.14257119
74Abnormality of the intervertebral disk (HP:0005108)2.13072565
75Small intestinal stenosis (HP:0012848)2.13011126
76Duodenal stenosis (HP:0100867)2.13011126
77Recurrent viral infections (HP:0004429)2.12039465
78Severe combined immunodeficiency (HP:0004430)2.11382843
79Abnormality of chromosome stability (HP:0003220)2.09910184
80Asymmetry of the thorax (HP:0001555)2.09432899
81Gonadotropin excess (HP:0000837)2.07061749
82Aplasia/Hypoplasia of the uvula (HP:0010293)2.06981180
83Decreased muscle mass (HP:0003199)2.06546265
84Macrocytic anemia (HP:0001972)2.05482386
85Viral hepatitis (HP:0006562)2.05193571
86Abnormality of serine family amino acid metabolism (HP:0010894)2.04221725
87Abnormality of glycine metabolism (HP:0010895)2.04221725
88Chromsome breakage (HP:0040012)2.01968571
89Abnormality of reticulocytes (HP:0004312)2.01802450
90Agnosia (HP:0010524)2.01434850
91Increased IgM level (HP:0003496)1.99853414
92Inappropriate behavior (HP:0000719)1.99008162
93Abnormality of T cell number (HP:0011839)1.98969415
94Abolished electroretinogram (ERG) (HP:0000550)1.98514072
95Popliteal pterygium (HP:0009756)1.97340299
96Aplasia/Hypoplasia of the sternum (HP:0006714)1.96834488
97Amaurosis fugax (HP:0100576)1.95582948
98T lymphocytopenia (HP:0005403)1.94746255
99Glossoptosis (HP:0000162)1.93817914
100Clitoromegaly (HP:0000057)1.93758429
101Abnormality of the 4th metacarpal (HP:0010012)1.93529000
102Cellular immunodeficiency (HP:0005374)1.92829210
103Spinal cord lesions (HP:0100561)1.92683814
104Syringomyelia (HP:0003396)1.92683814
105Postnatal microcephaly (HP:0005484)1.92447512
106Abnormality of the musculature of the pelvis (HP:0001469)1.92438773
107Abnormality of the hip-girdle musculature (HP:0001445)1.92438773
108Progressive inability to walk (HP:0002505)1.91978197
109Horseshoe kidney (HP:0000085)1.91613188
110Abnormality of the prostate (HP:0008775)1.90744831
111Thick lower lip vermilion (HP:0000179)1.90569025
112Chronic otitis media (HP:0000389)1.90224491
113Sacral dimple (HP:0000960)1.89802535
114Acute encephalopathy (HP:0006846)1.89437162
115Aplastic anemia (HP:0001915)1.89061292
116Heterotopia (HP:0002282)1.88933297
117Multiple enchondromatosis (HP:0005701)1.88832467
118Aplasia/Hypoplasia involving the musculature (HP:0001460)1.88628691
119Abnormality of the duodenum (HP:0002246)1.87869160
120Overlapping toe (HP:0001845)1.87797542
121Neoplasm of the pancreas (HP:0002894)1.86790855
122Increased number of teeth (HP:0011069)1.86594300
123Breast hypoplasia (HP:0003187)1.86544255
124Optic nerve coloboma (HP:0000588)1.85786958
125Petechiae (HP:0000967)1.85441317
126Abnormality of the vitamin B12 metabolism (HP:0004341)1.83925990
127Bifid tongue (HP:0010297)1.83557330
128Hypochromic anemia (HP:0001931)1.83532956
129Abnormality of the septum pellucidum (HP:0007375)1.82866253
13011 pairs of ribs (HP:0000878)1.81849815
131IgG deficiency (HP:0004315)1.81738097
132Malignant gastrointestinal tract tumors (HP:0006749)1.80593385
133Gastrointestinal carcinoma (HP:0002672)1.80593385
134Dyschromatopsia (HP:0007641)1.80075687
135Microvesicular hepatic steatosis (HP:0001414)1.78811095
136Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.78422133
137Abnormal gallbladder physiology (HP:0012438)1.77327987
138Cholecystitis (HP:0001082)1.77327987
139Chromosomal breakage induced by crosslinking agents (HP:0003221)1.76702287
140Glioma (HP:0009733)1.76392514
141Thyroiditis (HP:0100646)1.76082382
142Neoplasm of the colon (HP:0100273)1.75215821
143Hypoplasia of the thymus (HP:0000778)1.75036975
144Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74166662
145Abnormal protein N-linked glycosylation (HP:0012347)1.74166662
146Abnormal protein glycosylation (HP:0012346)1.74166662
147Abnormal glycosylation (HP:0012345)1.74166662
148Prostate neoplasm (HP:0100787)1.74112538
149Renal duplication (HP:0000075)1.73295717
150Acute myeloid leukemia (HP:0004808)1.72978984
151Pancytopenia (HP:0001876)1.72653939
152Upper limb muscle weakness (HP:0003484)1.71864931
153Abnormality of the preputium (HP:0100587)1.71435500
154Pancreatic islet-cell hyperplasia (HP:0004510)1.71322757
155Elfin facies (HP:0004428)1.71122736
156Short middle phalanx of the 5th finger (HP:0004220)1.70595756
157Abnormal platelet volume (HP:0011876)1.69134271
158Cleft eyelid (HP:0000625)1.68605953
159Sloping forehead (HP:0000340)1.68549160
160Small hand (HP:0200055)1.68498723
161Dandy-Walker malformation (HP:0001305)1.68263680
162Abnormality of the metopic suture (HP:0005556)1.67860735
163Shoulder girdle muscle weakness (HP:0003547)1.66817625
164Lymphoma (HP:0002665)1.66624773
165Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.66090530
166Rhabdomyosarcoma (HP:0002859)1.65945223
167Insomnia (HP:0100785)1.65603976
168Lissencephaly (HP:0001339)1.65055322
169Pendular nystagmus (HP:0012043)1.64748068
170Cafe-au-lait spot (HP:0000957)1.64599195
171Spinal cord compression (HP:0002176)1.64227230
172Wrist flexion contracture (HP:0001239)1.63886603
173Abnormality of the ileum (HP:0001549)1.62907254
174Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.62902832
175Poikilocytosis (HP:0004447)1.62197497
176Uterine neoplasm (HP:0010784)1.60942314
177Increased mean platelet volume (HP:0011877)1.60784302
178Abnormality of the carotid arteries (HP:0005344)1.59056527

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.97125404
2TRIM283.65835408
3CDC73.49044795
4EIF2AK33.25964928
5ERBB32.90767223
6EEF2K2.90226741
7MAP3K102.66952110
8DYRK22.50121449
9NUAK12.28915244
10ACVR1B2.27757593
11SRPK12.17406995
12NEK22.13951042
13DYRK32.11736039
14TNIK2.10119229
15VRK22.06428995
16PKN22.03385314
17PIM21.97476460
18TGFBR11.91264632
19MKNK11.74953833
20WEE11.74242019
21WNK31.73610937
22ZAK1.73118786
23SIK31.71032357
24SCYL21.70047426
25PBK1.68688423
26BUB11.55357538
27RPS6KB21.55140038
28EIF2AK11.51620934
29BMPR1B1.44434849
30PASK1.38835156
31TESK21.37651019
32TAF11.35195606
33RPS6KA41.34626376
34ATR1.32978821
35PLK21.30733344
36SIK21.30390344
37TXK1.28204581
38JAK31.25576536
39NME21.24190696
40STK161.20750795
41LRRK21.19833638
42PLK41.18109824
43EPHB21.17307605
44VRK11.17256955
45MUSK1.16537726
46PLK11.14945208
47CDK61.14314617
48MAP3K121.12782441
49MAPK131.12711516
50STK101.11450911
51TSSK61.10977694
52AURKB1.10748063
53TYK21.10176291
54PTK61.07810707
55MAP4K11.01828430
56MAP3K141.01754404
57CSNK1A1L1.01110570
58CCNB11.00588323
59FLT31.00361116
60PLK30.99403652
61STK30.98472312
62CHEK20.97560242
63CHUK0.96355845
64TESK10.95686107
65CDK70.95500873
66PAK40.94378301
67CHEK10.93629602
68CSNK1G30.93060184
69CDK40.90037194
70EIF2AK20.89207586
71MAPKAPK50.87990865
72DYRK1B0.87403340
73PIM10.86092343
74MAP3K80.85589445
75KDR0.85171539
76NEK10.84379311
77LIMK10.83442320
78TTK0.82865472
79MAP3K40.81112225
80TBK10.81040149
81ILK0.80893518
82CDK80.80811129
83ALK0.80061431
84GRK60.77848029
85MAP2K70.77560899
86TRIB30.77350403
87CASK0.77041130
88MAP3K60.75189657
89BRSK20.74657865
90CDK90.74614681
91TEC0.72961532
92MINK10.71701180
93MST40.70344106
94ATM0.68855028
95AURKA0.68009954
96BCKDK0.67071399
97STK40.65826407
98CDK20.65108541
99STK240.62844426
100CSNK1G20.60950740
101CLK10.60712976
102MKNK20.59697721
103KSR10.59047304
104MAP3K50.57586466
105EGFR0.55877538
106CDK120.55236179
107IKBKB0.55044749
108CSF1R0.54697499
109OXSR10.53661203
110GRK70.52305761
111KIT0.52241449
112CSNK1G10.50401739
113CDK140.49816936
114CDK10.49428801
115RPS6KA10.49207703
116BCR0.48775477
117BRSK10.48373440
118STK38L0.47006421
119MATK0.46931970
120DAPK10.46082572
121CDK180.45256827
122NTRK20.44502965
123FGFR10.42487424
124BTK0.42345609
125UHMK10.42338076
126CDK190.42174509
127CSNK2A20.41926779
128MAPK40.41655989
129TIE10.41152586
130PIK3CG0.40411422
131PAK10.39830426
132CSNK2A10.38953182
133MAPKAPK20.38820109
134MAPK90.38411679
135RAF10.38393224
136SYK0.38354521
137PAK20.38124271
138YES10.37773571
139ERBB40.37420304
140ERBB20.37418248
141BRD40.36805417
142IGF1R0.35615285
143MELK0.35606260
144MAP4K20.33348482
145FGR0.31553988
146CDK150.31512767
147CDK11A0.26146696
148PDK20.26033458

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.22774603
2Mismatch repair_Homo sapiens_hsa034303.21412049
3Ribosome_Homo sapiens_hsa030103.10608407
4Spliceosome_Homo sapiens_hsa030402.98776888
5Protein export_Homo sapiens_hsa030602.94284504
6Cell cycle_Homo sapiens_hsa041102.55496589
7Base excision repair_Homo sapiens_hsa034102.46863741
8Steroid biosynthesis_Homo sapiens_hsa001002.46833150
9Proteasome_Homo sapiens_hsa030502.45607231
10One carbon pool by folate_Homo sapiens_hsa006702.44838262
11RNA transport_Homo sapiens_hsa030132.31310537
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.13885579
13Nucleotide excision repair_Homo sapiens_hsa034202.06421789
14Propanoate metabolism_Homo sapiens_hsa006401.93597153
15mRNA surveillance pathway_Homo sapiens_hsa030151.87191020
16Fatty acid elongation_Homo sapiens_hsa000621.86848680
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85966362
18Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.85762422
19Homologous recombination_Homo sapiens_hsa034401.82682543
20Cysteine and methionine metabolism_Homo sapiens_hsa002701.74351245
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.70136072
22RNA polymerase_Homo sapiens_hsa030201.68584778
23Pyrimidine metabolism_Homo sapiens_hsa002401.68528239
24* p53 signaling pathway_Homo sapiens_hsa041151.60321133
25Pyruvate metabolism_Homo sapiens_hsa006201.56917987
26Antigen processing and presentation_Homo sapiens_hsa046121.54459917
27Chronic myeloid leukemia_Homo sapiens_hsa052201.54205837
28Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.51324761
29Allograft rejection_Homo sapiens_hsa053301.49765011
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44121639
31Epstein-Barr virus infection_Homo sapiens_hsa051691.42258520
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.39865719
33Non-homologous end-joining_Homo sapiens_hsa034501.39647935
34Fanconi anemia pathway_Homo sapiens_hsa034601.39435562
35* Viral carcinogenesis_Homo sapiens_hsa052031.39205730
36Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38099850
37Measles_Homo sapiens_hsa051621.37313762
38* Viral myocarditis_Homo sapiens_hsa054161.37230269
39Systemic lupus erythematosus_Homo sapiens_hsa053221.35411662
40RNA degradation_Homo sapiens_hsa030181.34229312
41Parkinsons disease_Homo sapiens_hsa050121.33826349
42* Colorectal cancer_Homo sapiens_hsa052101.32479990
43* Herpes simplex infection_Homo sapiens_hsa051681.31307431
44Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.30513832
45Small cell lung cancer_Homo sapiens_hsa052221.27992329
46Graft-versus-host disease_Homo sapiens_hsa053321.25402911
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.25402147
48* Apoptosis_Homo sapiens_hsa042101.24725413
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23238606
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.20716868
51Intestinal immune network for IgA production_Homo sapiens_hsa046721.12581746
52Shigellosis_Homo sapiens_hsa051311.08581789
53* MicroRNAs in cancer_Homo sapiens_hsa052061.07724530
54NF-kappa B signaling pathway_Homo sapiens_hsa040641.07313703
55Endometrial cancer_Homo sapiens_hsa052131.05143184
56Primary immunodeficiency_Homo sapiens_hsa053401.04527353
57Pancreatic cancer_Homo sapiens_hsa052121.04163208
58Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03396534
59HTLV-I infection_Homo sapiens_hsa051661.02813760
60Oxidative phosphorylation_Homo sapiens_hsa001901.00799141
61* Hepatitis B_Homo sapiens_hsa051611.00530538
62Biosynthesis of amino acids_Homo sapiens_hsa012300.99916307
63Carbon metabolism_Homo sapiens_hsa012000.99388406
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96681502
65Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94068688
66Leishmaniasis_Homo sapiens_hsa051400.91706350
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.90792326
68Acute myeloid leukemia_Homo sapiens_hsa052210.90535137
69T cell receptor signaling pathway_Homo sapiens_hsa046600.88946317
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88868409
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86976609
72Autoimmune thyroid disease_Homo sapiens_hsa053200.86462107
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.86408808
74Sulfur metabolism_Homo sapiens_hsa009200.85996387
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85525984
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84334915
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.82202138
78Basal transcription factors_Homo sapiens_hsa030220.82043210
79Glutathione metabolism_Homo sapiens_hsa004800.82016714
80Influenza A_Homo sapiens_hsa051640.81946654
81* Toxoplasmosis_Homo sapiens_hsa051450.80954931
82Hematopoietic cell lineage_Homo sapiens_hsa046400.79772714
83Peroxisome_Homo sapiens_hsa041460.76776305
84Regulation of autophagy_Homo sapiens_hsa041400.74005982
85Huntingtons disease_Homo sapiens_hsa050160.71422546
86Hepatitis C_Homo sapiens_hsa051600.71404216
87* TNF signaling pathway_Homo sapiens_hsa046680.71037854
88Asthma_Homo sapiens_hsa053100.70223560
89Non-small cell lung cancer_Homo sapiens_hsa052230.70136106
90* Legionellosis_Homo sapiens_hsa051340.69586265
91Thyroid cancer_Homo sapiens_hsa052160.67968823
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67172279
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67159500
94* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66669489
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66317812
96Alcoholism_Homo sapiens_hsa050340.65181631
97Prolactin signaling pathway_Homo sapiens_hsa049170.64552963
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.64294484
99Bladder cancer_Homo sapiens_hsa052190.64087519
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62888915
101B cell receptor signaling pathway_Homo sapiens_hsa046620.61814583
102Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59771016
103Hippo signaling pathway_Homo sapiens_hsa043900.59113393
104Phototransduction_Homo sapiens_hsa047440.58473560
105Selenocompound metabolism_Homo sapiens_hsa004500.58302010
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.57270882
107Adherens junction_Homo sapiens_hsa045200.56952828
108Oocyte meiosis_Homo sapiens_hsa041140.56879762
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55949059
110Toll-like receptor signaling pathway_Homo sapiens_hsa046200.55224524
111Notch signaling pathway_Homo sapiens_hsa043300.53032832
112Caffeine metabolism_Homo sapiens_hsa002320.52939603
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.52553429
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50661744
115Purine metabolism_Homo sapiens_hsa002300.50433403
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50149336
117TGF-beta signaling pathway_Homo sapiens_hsa043500.49436640
118Chemokine signaling pathway_Homo sapiens_hsa040620.45966895
119Axon guidance_Homo sapiens_hsa043600.45924818
120Vitamin B6 metabolism_Homo sapiens_hsa007500.45540525
121* Pathways in cancer_Homo sapiens_hsa052000.44869707
122Prostate cancer_Homo sapiens_hsa052150.44843887
123Metabolic pathways_Homo sapiens_hsa011000.43773612
124Fatty acid metabolism_Homo sapiens_hsa012120.43752478
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43718611
126Tryptophan metabolism_Homo sapiens_hsa003800.43298346
127N-Glycan biosynthesis_Homo sapiens_hsa005100.43274897
128Fatty acid degradation_Homo sapiens_hsa000710.42584861
129Type I diabetes mellitus_Homo sapiens_hsa049400.42575603
130Central carbon metabolism in cancer_Homo sapiens_hsa052300.41993960
131Osteoclast differentiation_Homo sapiens_hsa043800.41809623
132Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41322523
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.40785394
134VEGF signaling pathway_Homo sapiens_hsa043700.39110867
135Butanoate metabolism_Homo sapiens_hsa006500.38216388
136Salmonella infection_Homo sapiens_hsa051320.37495366
137mTOR signaling pathway_Homo sapiens_hsa041500.36713901
138Basal cell carcinoma_Homo sapiens_hsa052170.35640905
139Rheumatoid arthritis_Homo sapiens_hsa053230.35594607
140Alzheimers disease_Homo sapiens_hsa050100.33426146
141Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32909075
142Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.31170758
143Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.28572296
144Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.27698595
145Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25758707
146Renin-angiotensin system_Homo sapiens_hsa046140.25343400
147beta-Alanine metabolism_Homo sapiens_hsa004100.23124776
148Arginine and proline metabolism_Homo sapiens_hsa003300.22139180
149SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20192234
150Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.19341166
151Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.18495595

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