CASP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.41390921
2DNA unwinding involved in DNA replication (GO:0006268)5.07229803
3replication fork processing (GO:0031297)4.88496477
4DNA double-strand break processing (GO:0000729)4.64529911
5DNA strand elongation involved in DNA replication (GO:0006271)4.51576300
6telomere maintenance via semi-conservative replication (GO:0032201)4.49328815
7DNA strand elongation (GO:0022616)4.30578067
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.19899921
9DNA replication initiation (GO:0006270)4.18062038
10negative regulation of DNA-dependent DNA replication (GO:2000104)4.05498458
11telomere maintenance via recombination (GO:0000722)4.00634855
12RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.96385947
13mitotic recombination (GO:0006312)3.96102761
14viral transcription (GO:0019083)3.95994481
15maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.95782889
16protein K6-linked ubiquitination (GO:0085020)3.82555570
17response to pheromone (GO:0019236)3.78474640
18translational termination (GO:0006415)3.77633831
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.73600980
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.73600980
21DNA catabolic process, exonucleolytic (GO:0000738)3.67185856
22cullin deneddylation (GO:0010388)3.64006727
23nucleotide-excision repair, DNA gap filling (GO:0006297)3.61167582
24mitotic sister chromatid cohesion (GO:0007064)3.57154961
25recombinational repair (GO:0000725)3.56359027
26double-strand break repair via homologous recombination (GO:0000724)3.55795070
27respiratory chain complex IV assembly (GO:0008535)3.53626338
28negative regulation of RNA splicing (GO:0033119)3.48902352
29protein deneddylation (GO:0000338)3.48812416
30mitotic chromosome condensation (GO:0007076)3.45878653
31positive regulation of gamma-delta T cell activation (GO:0046645)3.45569593
32L-fucose metabolic process (GO:0042354)3.45063706
33L-fucose catabolic process (GO:0042355)3.45063706
34fucose catabolic process (GO:0019317)3.45063706
35exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.40848336
36telomere maintenance via telomere lengthening (GO:0010833)3.40679944
37antigen processing and presentation of endogenous antigen (GO:0019883)3.38620048
38nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.38465357
39SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.38427091
40negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.36232638
41proteasome assembly (GO:0043248)3.35457922
42translational elongation (GO:0006414)3.35034638
43regulation of mitotic spindle checkpoint (GO:1903504)3.34372944
44regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.34372944
45definitive hemopoiesis (GO:0060216)3.34099043
46DNA topological change (GO:0006265)3.32929892
47negative regulation of phagocytosis (GO:0050765)3.31107409
48synapsis (GO:0007129)3.28460942
49cotranslational protein targeting to membrane (GO:0006613)3.27941427
50protein targeting to ER (GO:0045047)3.26121857
51cytochrome complex assembly (GO:0017004)3.24718414
52nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.24551937
53regulation of helicase activity (GO:0051095)3.16619313
54protein localization to kinetochore (GO:0034501)3.13734523
55ribosomal small subunit biogenesis (GO:0042274)3.13671052
56centriole replication (GO:0007099)3.13591366
57DNA strand renaturation (GO:0000733)3.13237386
58DNA replication-independent nucleosome assembly (GO:0006336)3.12441658
59DNA replication-independent nucleosome organization (GO:0034724)3.12441658
60establishment of protein localization to endoplasmic reticulum (GO:0072599)3.09032166
61histone exchange (GO:0043486)3.07673571
62somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.07328933
63somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.07328933
64isotype switching (GO:0045190)3.07328933
65CENP-A containing nucleosome assembly (GO:0034080)3.06916432
66purine nucleobase biosynthetic process (GO:0009113)3.06882684
67platelet dense granule organization (GO:0060155)3.05625540
68kinetochore assembly (GO:0051382)3.03407097
69translesion synthesis (GO:0019985)3.03192302
70kinetochore organization (GO:0051383)3.01543837
71DNA ligation (GO:0006266)3.01389368
72negative regulation of DNA recombination (GO:0045910)3.01000055
73protein localization to endoplasmic reticulum (GO:0070972)3.00740291
74nucleobase biosynthetic process (GO:0046112)2.99795308
75V(D)J recombination (GO:0033151)2.98809330
76megakaryocyte development (GO:0035855)2.98144027
77DNA recombination (GO:0006310)2.98009036
78maturation of SSU-rRNA (GO:0030490)2.97062858
79viral life cycle (GO:0019058)2.96501423
80preassembly of GPI anchor in ER membrane (GO:0016254)2.96478520
81DNA duplex unwinding (GO:0032508)2.95877938
82chromatin remodeling at centromere (GO:0031055)2.95136970
83negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.94470126
84neural tube formation (GO:0001841)2.94419231
85meiotic chromosome segregation (GO:0045132)2.93541003
86DNA geometric change (GO:0032392)2.92674663
87DNA replication checkpoint (GO:0000076)2.92577738
88pseudouridine synthesis (GO:0001522)2.92303091
89positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.91437590
90negative regulation of mRNA processing (GO:0050686)2.91256186
91translational initiation (GO:0006413)2.90775296
92double-strand break repair (GO:0006302)2.90695776
93regulation of centriole replication (GO:0046599)2.90267790
94somatic diversification of immune receptors (GO:0002200)2.89698835
95lactate metabolic process (GO:0006089)2.89265255
96mannosylation (GO:0097502)2.88527756
97nuclear pore complex assembly (GO:0051292)2.88076065
98cellular protein complex disassembly (GO:0043624)2.87902802
99alternative mRNA splicing, via spliceosome (GO:0000380)2.87625125
100regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.87383913
101dosage compensation (GO:0007549)2.86562984
102non-recombinational repair (GO:0000726)2.85293236
103double-strand break repair via nonhomologous end joining (GO:0006303)2.85293236
104T cell homeostasis (GO:0043029)2.85126291
105positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.83768886
106somatic diversification of immunoglobulins (GO:0016445)2.83611054
107DNA replication-dependent nucleosome assembly (GO:0006335)2.82349543
108DNA replication-dependent nucleosome organization (GO:0034723)2.82349543
109nuclear-transcribed mRNA catabolic process (GO:0000956)2.81102585
110* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.78321028
111* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.78321028
112* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.78321028
113nuclear pore organization (GO:0006999)2.78093542
114deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.77591684
115termination of RNA polymerase II transcription (GO:0006369)2.77201367
116mismatch repair (GO:0006298)2.76949376
117* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.76925368
118telomere maintenance (GO:0000723)2.76921891
119regulation of gamma-delta T cell differentiation (GO:0045586)2.76745767
120protein complex disassembly (GO:0043241)2.76461763
121rRNA modification (GO:0000154)2.76413925
122telomere organization (GO:0032200)2.76302010
123maturation of 5.8S rRNA (GO:0000460)2.75272802
124protein localization to chromosome, centromeric region (GO:0071459)2.74711159
125protein complex biogenesis (GO:0070271)2.72617055
126regulation of nuclear cell cycle DNA replication (GO:0033262)2.72525955
127mRNA splicing, via spliceosome (GO:0000398)2.71948854
128RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.71948854
129* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.71585699
130* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.71585699
131IMP biosynthetic process (GO:0006188)2.71373006
132DNA deamination (GO:0045006)2.71253901
133mRNA catabolic process (GO:0006402)2.69965531
134* signal transduction involved in cell cycle checkpoint (GO:0072395)2.69427463
135DNA synthesis involved in DNA repair (GO:0000731)2.69212831
136regulation of DNA endoreduplication (GO:0032875)2.68214337
137RNA splicing, via transesterification reactions (GO:0000375)2.68140417
138regulation of histone H3-K9 methylation (GO:0051570)2.67992129
139histone H2A acetylation (GO:0043968)2.67714739
140negative regulation of thymocyte apoptotic process (GO:0070244)2.67586106
141positive regulation of B cell differentiation (GO:0045579)2.67382171
142regulation of B cell receptor signaling pathway (GO:0050855)2.66741379
143regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.66555197
144DNA conformation change (GO:0071103)2.65937440
1453-UTR-mediated mRNA stabilization (GO:0070935)2.65531730
146anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.64672083
147base-excision repair (GO:0006284)2.64363218
148somatic recombination of immunoglobulin gene segments (GO:0016447)2.64300942
149negative regulation of mRNA metabolic process (GO:1903312)2.64286064
150regulation of B cell differentiation (GO:0045577)2.63656421
151DNA demethylation (GO:0080111)2.63576412
152chromatin assembly or disassembly (GO:0006333)2.63380800
153reciprocal meiotic recombination (GO:0007131)2.63169903
154reciprocal DNA recombination (GO:0035825)2.63169903
155sister chromatid segregation (GO:0000819)2.62946969
156mitochondrial respiratory chain complex assembly (GO:0033108)2.62161143
157L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.61929534
158RNA catabolic process (GO:0006401)2.61849590
159somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.61741671
160somatic cell DNA recombination (GO:0016444)2.61741671
161* signal transduction involved in DNA damage checkpoint (GO:0072422)2.61083723
162* signal transduction involved in DNA integrity checkpoint (GO:0072401)2.61083723
163resolution of meiotic recombination intermediates (GO:0000712)2.61083303
164formation of translation preinitiation complex (GO:0001731)2.60079027
165intra-S DNA damage checkpoint (GO:0031573)2.58109257
166antigen processing and presentation via MHC class Ib (GO:0002475)2.57594574
167ATP-dependent chromatin remodeling (GO:0043044)2.56195100
168macromolecular complex disassembly (GO:0032984)2.55506278
169somatic hypermutation of immunoglobulin genes (GO:0016446)2.54418761
170somatic diversification of immune receptors via somatic mutation (GO:0002566)2.54418761
171postreplication repair (GO:0006301)2.53639230

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.99353707
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.96609750
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.66558434
4SALL1_21062744_ChIP-ChIP_HESCs_Human3.20313336
5ZNF274_21170338_ChIP-Seq_K562_Hela3.10539896
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.01585872
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.95153295
8* MYC_18555785_ChIP-Seq_MESCs_Mouse2.94208332
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.89757686
10MYC_22102868_ChIP-Seq_BL_Human2.74848704
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.53409491
12SCL_19346495_ChIP-Seq_HPC-7_Human2.49893800
13EWS_26573619_Chip-Seq_HEK293_Human2.48999337
14VDR_22108803_ChIP-Seq_LS180_Human2.48897452
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.32068599
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.27869142
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.26058429
18CIITA_25753668_ChIP-Seq_RAJI_Human2.23452809
19IGF1R_20145208_ChIP-Seq_DFB_Human2.18646516
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.17336547
21TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.12173337
22* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.10871747
23ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.09366168
24* E2F1_21310950_ChIP-Seq_MCF-7_Human2.08230394
25VDR_21846776_ChIP-Seq_THP-1_Human2.05516758
26FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.02228706
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.01795468
28EST1_17652178_ChIP-ChIP_JURKAT_Human1.98211975
29FUS_26573619_Chip-Seq_HEK293_Human1.97692966
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92123822
31* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.92038080
32HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.90586196
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.90506070
34VDR_23849224_ChIP-Seq_CD4+_Human1.90337695
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.89741931
36HOXB4_20404135_ChIP-ChIP_EML_Mouse1.89474099
37MYC_19079543_ChIP-ChIP_MESCs_Mouse1.88303820
38SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.87031632
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.86029288
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.83441612
41* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.83033994
42AR_21909140_ChIP-Seq_LNCAP_Human1.82977197
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.82735645
44FOXP3_21729870_ChIP-Seq_TREG_Human1.81038585
45MYC_18940864_ChIP-ChIP_HL60_Human1.81035865
46XRN2_22483619_ChIP-Seq_HELA_Human1.80221126
47SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.78923894
48* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77488384
49* SPI1_23547873_ChIP-Seq_NB4_Human1.76431920
50ERG_20887958_ChIP-Seq_HPC-7_Mouse1.74350624
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.72491055
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72154559
53SRF_21415370_ChIP-Seq_HL-1_Mouse1.71510995
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.71436216
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.70143829
56* MYB_26560356_Chip-Seq_TH2_Human1.66641484
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60772846
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60468551
59CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.60249634
60ELK1_19687146_ChIP-ChIP_HELA_Human1.58253718
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.57593984
62RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55403721
63GBX2_23144817_ChIP-Seq_PC3_Human1.54182361
64MAF_26560356_Chip-Seq_TH1_Human1.53392338
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.51149517
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.50967978
67GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.50655852
68P300_19829295_ChIP-Seq_ESCs_Human1.50408653
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48757250
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.48241683
71MYB_26560356_Chip-Seq_TH1_Human1.47866875
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46333652
73UTX_26944678_Chip-Seq_JUKART_Human1.46116745
74IRF1_19129219_ChIP-ChIP_H3396_Human1.45872018
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.43981570
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.43581084
77TTF2_22483619_ChIP-Seq_HELA_Human1.42578069
78* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42159405
79VDR_24763502_ChIP-Seq_THP-1_Human1.41565988
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.39745908
81* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38808853
82MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.38153841
83TAF15_26573619_Chip-Seq_HEK293_Human1.37546890
84CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37020304
85CREB1_15753290_ChIP-ChIP_HEK293T_Human1.36711100
86RUNX1_22412390_ChIP-Seq_EML_Mouse1.36263094
87FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35288125
88* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.34533682
89GATA1_22025678_ChIP-Seq_K562_Human1.34296464
90ER_23166858_ChIP-Seq_MCF-7_Human1.33725692
91MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33288911
92NOTCH1_21737748_ChIP-Seq_TLL_Human1.32657556
93DCP1A_22483619_ChIP-Seq_HELA_Human1.31587911
94TCF7_22412390_ChIP-Seq_EML_Mouse1.29210022
95GABP_19822575_ChIP-Seq_HepG2_Human1.28903176
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.28762629
97POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28231628
98* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25728140
99CTBP1_25329375_ChIP-Seq_LNCAP_Human1.25396036
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24763509
101STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.24206364
102* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.22786765
103IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22451801
104CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21052030
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.20154071
106CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19731370
107TP53_22573176_ChIP-Seq_HFKS_Human1.17462742
108EZH2_27294783_Chip-Seq_NPCs_Mouse1.17397470
109GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15432966
110BRD4_27068464_Chip-Seq_AML-cells_Mouse1.13681601
111KDM5A_27292631_Chip-Seq_BREAST_Human1.13380614
112NFE2_27457419_Chip-Seq_LIVER_Mouse1.12902454
113NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.11503041
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10539505
115NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.10322459
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10090978
117GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09835912
118NANOG_19829295_ChIP-Seq_ESCs_Human1.09304714
119SOX2_19829295_ChIP-Seq_ESCs_Human1.09304714
120GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09274810
121SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08593594
122PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08323723
123DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08172235
124HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07911013
125E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07427793
126CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06509507
127PCGF2_27294783_Chip-Seq_NPCs_Mouse1.06486027
128* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.06343729
129* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05173426
130IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.04326995
131CBP_20019798_ChIP-Seq_JUKART_Human1.04326995
132RUNX_20019798_ChIP-Seq_JUKART_Human1.03299531
133* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00833141
134UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00665094
135BCAT_22108803_ChIP-Seq_LS180_Human1.00575143
136TFEB_21752829_ChIP-Seq_HELA_Human0.98820242
137THAP11_20581084_ChIP-Seq_MESCs_Mouse0.97374012
138GATA3_26560356_Chip-Seq_TH2_Human0.96445083
139IRF8_27001747_Chip-Seq_BMDM_Mouse0.95464517
140YY1_21170310_ChIP-Seq_MESCs_Mouse0.94454446
141FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94318120
142FOXA1_25329375_ChIP-Seq_VCAP_Human0.94318120
143CRX_20693478_ChIP-Seq_RETINA_Mouse0.93868778
144AR_20517297_ChIP-Seq_VCAP_Human0.93816797
145FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93562358
146CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.93542839
147ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93069005
148MAF_26560356_Chip-Seq_TH2_Human0.92799364
149TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92796241
150LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91810227
151TCF4_22108803_ChIP-Seq_LS180_Human0.89245760
152FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87852380
153MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87781079
154HOXB7_26014856_ChIP-Seq_BT474_Human0.85797568
155SALL4_22934838_ChIP-ChIP_CD34+_Human0.85661050
156RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.84996622
157AR_25329375_ChIP-Seq_VCAP_Human0.84343229
158CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83417413
159ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83134410

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.98789984
2MP0010094_abnormal_chromosome_stability3.47991352
3MP0008057_abnormal_DNA_replication2.94879464
4MP0003693_abnormal_embryo_hatching2.89805780
5MP0002102_abnormal_ear_morphology2.88144726
6MP0003763_abnormal_thymus_physiology2.84248490
7MP0004808_abnormal_hematopoietic_stem2.67474623
8MP0003077_abnormal_cell_cycle2.66845411
9MP0000372_irregular_coat_pigmentation2.61520482
10MP0003111_abnormal_nucleus_morphology2.60782088
11MP0001835_abnormal_antigen_presentation2.58789206
12MP0006054_spinal_hemorrhage2.37717381
13MP0008058_abnormal_DNA_repair2.34470190
14MP0003718_maternal_effect2.29786107
15MP0004957_abnormal_blastocyst_morpholog2.25294769
16MP0002398_abnormal_bone_marrow2.22421331
17MP0008007_abnormal_cellular_replicative2.20899089
18MP0000569_abnormal_digit_pigmentation2.11879096
19MP0005671_abnormal_response_to2.08256553
20MP0000490_abnormal_crypts_of2.03505093
21MP0001800_abnormal_humoral_immune1.99640702
22MP0000685_abnormal_immune_system1.94851801
23MP0005174_abnormal_tail_pigmentation1.94256410
24MP0010352_gastrointestinal_tract_polyps1.92361705
25MP0005397_hematopoietic_system_phenotyp1.91387223
26MP0001545_abnormal_hematopoietic_system1.91387223
27MP0002166_altered_tumor_susceptibility1.88514951
28MP0000703_abnormal_thymus_morphology1.88434797
29* MP0002420_abnormal_adaptive_immunity1.82851953
30MP0005367_renal/urinary_system_phenotyp1.80201102
31MP0000516_abnormal_urinary_system1.80201102
32MP0000689_abnormal_spleen_morphology1.80194647
33* MP0001819_abnormal_immune_cell1.79275488
34MP0002722_abnormal_immune_system1.79171903
35MP0006072_abnormal_retinal_apoptosis1.77069102
36MP0002095_abnormal_skin_pigmentation1.75805663
37MP0005075_abnormal_melanosome_morpholog1.74737708
38* MP0002452_abnormal_antigen_presenting1.73927799
39MP0000716_abnormal_immune_system1.72318145
40MP0003195_calcinosis1.69399214
41MP0000465_gastrointestinal_hemorrhage1.69295214
42MP0009333_abnormal_splenocyte_physiolog1.66355602
43MP0009278_abnormal_bone_marrow1.64208414
44MP0002429_abnormal_blood_cell1.63223150
45MP0005646_abnormal_pituitary_gland1.62638730
46MP0008872_abnormal_physiological_respon1.61167462
47MP0002723_abnormal_immune_serum1.60463422
48MP0001873_stomach_inflammation1.57316098
49MP0009785_altered_susceptibility_to1.56657894
50MP0002234_abnormal_pharynx_morphology1.55069332
51MP0010307_abnormal_tumor_latency1.53315236
52MP0005000_abnormal_immune_tolerance1.49942137
53MP0005025_abnormal_response_to1.49436626
54MP0002405_respiratory_system_inflammati1.47360992
55MP0005551_abnormal_eye_electrophysiolog1.46162839
56MP0003806_abnormal_nucleotide_metabolis1.43071654
57MP0002019_abnormal_tumor_incidence1.42523821
58MP0005253_abnormal_eye_physiology1.41085952
59MP0003866_abnormal_defecation1.40827401
60MP0002006_tumorigenesis1.40515097
61MP0010155_abnormal_intestine_physiology1.39307750
62MP0001790_abnormal_immune_system1.39269785
63MP0005387_immune_system_phenotype1.39269785
64MP0002148_abnormal_hypersensitivity_rea1.39212534
65MP0000350_abnormal_cell_proliferation1.38916809
66MP0001986_abnormal_taste_sensitivity1.36470852
67MP0005464_abnormal_platelet_physiology1.35904189
68MP0006036_abnormal_mitochondrial_physio1.35321315
69MP0000015_abnormal_ear_pigmentation1.30516561
70MP0005645_abnormal_hypothalamus_physiol1.25516801
71* MP0001929_abnormal_gametogenesis1.22192298
72MP0000631_abnormal_neuroendocrine_gland1.21429159
73* MP0000313_abnormal_cell_death1.20994207
74MP0003786_premature_aging1.20783045
75MP0003123_paternal_imprinting1.19374169
76MP0001764_abnormal_homeostasis1.18550451
77MP0003121_genomic_imprinting1.18454389
78MP0002419_abnormal_innate_immunity1.14953317
79MP0003436_decreased_susceptibility_to1.13431216
80MP0001968_abnormal_touch/_nociception1.13163454
81MP0005084_abnormal_gallbladder_morpholo1.12785053
82MP0002282_abnormal_trachea_morphology1.12080557
83MP0000427_abnormal_hair_cycle1.11613015
84MP0002210_abnormal_sex_determination1.08709735
85MP0005395_other_phenotype1.08404706
86MP0008877_abnormal_DNA_methylation1.07796547
87MP0008932_abnormal_embryonic_tissue1.07182626
88MP0001730_embryonic_growth_arrest1.06511902
89MP0000858_altered_metastatic_potential1.06453702
90MP0003943_abnormal_hepatobiliary_system1.06188469
91MP0002736_abnormal_nociception_after1.04220242
92* MP0000653_abnormal_sex_gland1.03603361
93MP0001145_abnormal_male_reproductive1.03085476
94MP0006035_abnormal_mitochondrial_morpho1.02868954
95MP0008789_abnormal_olfactory_epithelium1.02603480
96* MP0002751_abnormal_autonomic_nervous1.00130260
97MP0003880_abnormal_central_pattern1.00073707
98MP0006292_abnormal_olfactory_placode0.98448528
99MP0005076_abnormal_cell_differentiation0.97511968
100MP0001529_abnormal_vocalization0.97104978
101MP0001853_heart_inflammation0.96892977
102MP0003300_gastrointestinal_ulcer0.95548893
103MP0003698_abnormal_male_reproductive0.95199072
104* MP0001119_abnormal_female_reproductive0.95136871
105MP0002938_white_spotting0.94093812
106MP0001845_abnormal_inflammatory_respons0.93553293
107MP0008995_early_reproductive_senescence0.92098583
108MP0004147_increased_porphyrin_level0.90706219
109MP0008775_abnormal_heart_ventricle0.89610997
110MP0009697_abnormal_copulation0.88142750
111MP0001697_abnormal_embryo_size0.87896683
112MP0002075_abnormal_coat/hair_pigmentati0.87709149
113MP0002080_prenatal_lethality0.86110743
114MP0004947_skin_inflammation0.85788646
115MP0003567_abnormal_fetal_cardiomyocyte0.84562321
116MP0005389_reproductive_system_phenotype0.84488118
117MP0003646_muscle_fatigue0.80765196
118MP0002160_abnormal_reproductive_system0.80543598
119MP0000477_abnormal_intestine_morphology0.80349216
120MP0001672_abnormal_embryogenesis/_devel0.80266606
121MP0005380_embryogenesis_phenotype0.80266606
122MP0002086_abnormal_extraembryonic_tissu0.79086909
123MP0004197_abnormal_fetal_growth/weight/0.78115099
124MP0000647_abnormal_sebaceous_gland0.77919693
125MP0003984_embryonic_growth_retardation0.77695618
126MP0000613_abnormal_salivary_gland0.77582604
127MP0002009_preneoplasia0.77305527
128MP0000371_diluted_coat_color0.76936511
129MP0001485_abnormal_pinna_reflex0.75746822
130MP0004043_abnormal_pH_regulation0.75737847
131MP0002088_abnormal_embryonic_growth/wei0.75263729
132MP0001293_anophthalmia0.73103889
133MP0005410_abnormal_fertilization0.73102776
134MP0001324_abnormal_eye_pigmentation0.72535218
135MP0002933_joint_inflammation0.72019389
136MP0005409_darkened_coat_color0.72005893
137MP0008875_abnormal_xenobiotic_pharmacok0.71774273
138MP0005220_abnormal_exocrine_pancreas0.71770708
139MP0001186_pigmentation_phenotype0.71414613
140MP0003787_abnormal_imprinting0.70478760
141MP0001984_abnormal_olfaction0.70414944
142MP0004264_abnormal_extraembryonic_tissu0.69161888
143MP0003448_altered_tumor_morphology0.68215564
144MP0003937_abnormal_limbs/digits/tail_de0.67003827
145MP0003303_peritoneal_inflammation0.66735773
146MP0001915_intracranial_hemorrhage0.66708881
147MP0000383_abnormal_hair_follicle0.66332615
148MP0003828_pulmonary_edema0.65648112
149MP0002085_abnormal_embryonic_tissue0.64037508
150MP0003186_abnormal_redox_activity0.62737860
151MP0004381_abnormal_hair_follicle0.62665137
152MP0002132_abnormal_respiratory_system0.62660409
153MP0008873_increased_physiological_sensi0.61353529
154MP0005171_absent_coat_pigmentation0.60511736
155MP0005391_vision/eye_phenotype0.58045693
156MP0006276_abnormal_autonomic_nervous0.57984989
157MP0001919_abnormal_reproductive_system0.57844727
158MP0000358_abnormal_cell_content/0.56620197
159MP0001286_abnormal_eye_development0.56036283
160MP0003119_abnormal_digestive_system0.54072996

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)4.13296864
2Reticulocytopenia (HP:0001896)3.81218904
3Thrombocytosis (HP:0001894)3.70785272
4Abnormality of cells of the erythroid lineage (HP:0012130)3.59632363
5Abnormal number of erythroid precursors (HP:0012131)3.55004373
6Pancreatic cysts (HP:0001737)3.46093398
7Chronic otitis media (HP:0000389)3.18460704
8Thyroiditis (HP:0100646)3.15590669
9Abnormality of the labia minora (HP:0012880)3.13395818
10Volvulus (HP:0002580)3.10088903
11Recurrent viral infections (HP:0004429)3.00897622
12Chromsome breakage (HP:0040012)2.98636594
13Pancreatic fibrosis (HP:0100732)2.97518081
14Abnormality of the fingertips (HP:0001211)2.97269967
15True hermaphroditism (HP:0010459)2.94121792
16Colon cancer (HP:0003003)2.89619415
17Petechiae (HP:0000967)2.85648742
18Molar tooth sign on MRI (HP:0002419)2.85470062
19Abnormality of midbrain morphology (HP:0002418)2.85470062
20Recurrent bronchitis (HP:0002837)2.82554029
21Myelodysplasia (HP:0002863)2.78400166
22Short 4th metacarpal (HP:0010044)2.75585463
23Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.75585463
24T lymphocytopenia (HP:0005403)2.74181473
25Chromosomal breakage induced by crosslinking agents (HP:0003221)2.73672297
26Amaurosis fugax (HP:0100576)2.72691386
27Neoplasm of the adrenal cortex (HP:0100641)2.71126957
28Lymphoma (HP:0002665)2.67982427
29Panhypogammaglobulinemia (HP:0003139)2.66772344
30Abnormality of T cells (HP:0002843)2.64251098
3111 pairs of ribs (HP:0000878)2.63979377
32Aplastic anemia (HP:0001915)2.62597320
33Acute myeloid leukemia (HP:0004808)2.62301217
34B lymphocytopenia (HP:0010976)2.61172944
35Abnormality of B cell number (HP:0010975)2.61172944
36Nephronophthisis (HP:0000090)2.60384182
37Abnormal delayed hypersensitivity skin test (HP:0002963)2.59508744
38Elevated erythrocyte sedimentation rate (HP:0003565)2.56299522
39Spinal cord lesions (HP:0100561)2.55524300
40Syringomyelia (HP:0003396)2.55524300
41Abnormality of T cell physiology (HP:0011840)2.51065610
42Myositis (HP:0100614)2.49538993
43Methylmalonic acidemia (HP:0002912)2.49471910
44Abnormality of T cell number (HP:0011839)2.48027776
45Basal cell carcinoma (HP:0002671)2.45555413
46Prolonged bleeding time (HP:0003010)2.44136884
47IgG deficiency (HP:0004315)2.42465915
48Albinism (HP:0001022)2.41547312
49Pendular nystagmus (HP:0012043)2.41044652
50Agnosia (HP:0010524)2.40610723
51Increased nuchal translucency (HP:0010880)2.39226286
52Prostate neoplasm (HP:0100787)2.38145049
53Birth length less than 3rd percentile (HP:0003561)2.36952619
54Medulloblastoma (HP:0002885)2.36181064
55Abnormality of chromosome stability (HP:0003220)2.35433745
56Sloping forehead (HP:0000340)2.33190625
573-Methylglutaconic aciduria (HP:0003535)2.32958597
58Abolished electroretinogram (ERG) (HP:0000550)2.32380934
59Recurrent abscess formation (HP:0002722)2.32281309
60Glioma (HP:0009733)2.31253328
61Severe combined immunodeficiency (HP:0004430)2.31052115
62Cellulitis (HP:0100658)2.30341152
63Progressive inability to walk (HP:0002505)2.28630476
64Congenital stationary night blindness (HP:0007642)2.28042630
65Abnormality of the renal medulla (HP:0100957)2.27881022
66Meningitis (HP:0001287)2.27594142
67Spontaneous hematomas (HP:0007420)2.27434757
68Recurrent fungal infections (HP:0002841)2.27011655
69Hypoproteinemia (HP:0003075)2.27001121
70Abnormality of the prostate (HP:0008775)2.26658353
71Abnormality of the renal cortex (HP:0011035)2.26566859
72Acute lymphatic leukemia (HP:0006721)2.23813357
73Increased CSF lactate (HP:0002490)2.23093203
74Pallor (HP:0000980)2.23035837
75Hypothermia (HP:0002045)2.22897496
76Hepatocellular necrosis (HP:0001404)2.21717772
77Abnormality of the astrocytes (HP:0100707)2.19245690
78Astrocytoma (HP:0009592)2.19245690
79Agammaglobulinemia (HP:0004432)2.17398665
80Acute necrotizing encephalopathy (HP:0006965)2.15165832
81Type I transferrin isoform profile (HP:0003642)2.13480031
82Duodenal stenosis (HP:0100867)2.12070739
83Small intestinal stenosis (HP:0012848)2.12070739
84Stomach cancer (HP:0012126)2.10907295
85Acute encephalopathy (HP:0006846)2.10733566
86Combined immunodeficiency (HP:0005387)2.10673742
87Abnormality of the preputium (HP:0100587)2.09525030
88Methylmalonic aciduria (HP:0012120)2.09336667
89Progressive macrocephaly (HP:0004481)2.08567351
90Mitochondrial inheritance (HP:0001427)2.08070390
91Neoplasm of the adrenal gland (HP:0100631)2.07786972
92Lymphopenia (HP:0001888)2.05579449
93Proximal placement of thumb (HP:0009623)2.04487302
94Cutis marmorata (HP:0000965)2.03914514
95Optic nerve coloboma (HP:0000588)2.03827050
96Poikiloderma (HP:0001029)2.03478926
97Abnormality of cells of the lymphoid lineage (HP:0012140)2.02742755
98Small hand (HP:0200055)2.01626143
99Hepatic necrosis (HP:0002605)2.01235623
100Attenuation of retinal blood vessels (HP:0007843)2.00307230
101Bone marrow hypocellularity (HP:0005528)1.99871382
102Gastrointestinal inflammation (HP:0004386)1.99725921
103Abnormal biliary tract physiology (HP:0012439)1.98933511
104Bile duct proliferation (HP:0001408)1.98933511
105Meckel diverticulum (HP:0002245)1.98314845
106Abnormality of the heme biosynthetic pathway (HP:0010472)1.97450288
107Abnormality of DNA repair (HP:0003254)1.96215594
108Mediastinal lymphadenopathy (HP:0100721)1.94862602
109Recurrent bacterial skin infections (HP:0005406)1.94404383
110Abnormal lung lobation (HP:0002101)1.93440580
111Deviation of the thumb (HP:0009603)1.92844261
112Aplasia/Hypoplasia of the uvula (HP:0010293)1.90604251
113Aplasia/Hypoplasia of the patella (HP:0006498)1.90586215
114Ectopic kidney (HP:0000086)1.90512975
115Abnormality of the ileum (HP:0001549)1.90458344
116Clubbing of toes (HP:0100760)1.89129074
117Cystic liver disease (HP:0006706)1.88402981
118Increased serum lactate (HP:0002151)1.87088449
119Chronic hepatic failure (HP:0100626)1.87085832
120Ependymoma (HP:0002888)1.86430396
121Pancreatic islet-cell hyperplasia (HP:0004510)1.86233181
122Absent thumb (HP:0009777)1.86108536
123Macrocytic anemia (HP:0001972)1.85690230
124Triphalangeal thumb (HP:0001199)1.84584153
125Duplicated collecting system (HP:0000081)1.84561571
126Abnormal protein glycosylation (HP:0012346)1.83383468
127Abnormal glycosylation (HP:0012345)1.83383468
128Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83383468
129Abnormal protein N-linked glycosylation (HP:0012347)1.83383468
130Renal cortical cysts (HP:0000803)1.83060163
131Medial flaring of the eyebrow (HP:0010747)1.81671803
132Verrucae (HP:0200043)1.81605036
133Papilloma (HP:0012740)1.81605036
134Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80704642
135Hypochromic microcytic anemia (HP:0004840)1.80566576
136Sclerocornea (HP:0000647)1.80404626
137Decreased electroretinogram (ERG) amplitude (HP:0000654)1.80358440
138Abnormality of the carotid arteries (HP:0005344)1.79860768
139Patellar aplasia (HP:0006443)1.79707865
140Hypoplasia of the thymus (HP:0000778)1.79296583
141Aqueductal stenosis (HP:0002410)1.79194356
142Prominent nose (HP:0000448)1.78806701
143Hyperacusis (HP:0010780)1.78565576
144High pitched voice (HP:0001620)1.78358953
145Inflammation of the large intestine (HP:0002037)1.77872645
146Cutaneous melanoma (HP:0012056)1.77751183
147Selective tooth agenesis (HP:0001592)1.77398434
148Intestinal atresia (HP:0011100)1.77177649
149Abnormal platelet function (HP:0011869)1.76662617
150Impaired platelet aggregation (HP:0003540)1.76662617
151Abnormal mitochondria in muscle tissue (HP:0008316)1.75273260
152Aplasia/Hypoplasia of the tongue (HP:0010295)1.75064739
153Congenital, generalized hypertrichosis (HP:0004540)1.74911091
154Long eyelashes (HP:0000527)1.74500225
155Periodontitis (HP:0000704)1.74465418
156Abnormality of the duodenum (HP:0002246)1.74129552
157Dandy-Walker malformation (HP:0001305)1.74125996
158IgA deficiency (HP:0002720)1.73292186
159Autoimmune hemolytic anemia (HP:0001890)1.73203824
160Preaxial hand polydactyly (HP:0001177)1.72917366
161Ureteral stenosis (HP:0000071)1.72517708
162Chronic diarrhea (HP:0002028)1.71885982
163Hyperventilation (HP:0002883)1.71873720
164Abnormality of the renal collecting system (HP:0004742)1.70993409
165Microretrognathia (HP:0000308)1.70665503
166Epistaxis (HP:0000421)1.70622311
167Anencephaly (HP:0002323)1.70293337
168Eosinophilia (HP:0001880)1.69616725
169Pancytopenia (HP:0001876)1.69615609
170Fair hair (HP:0002286)1.64091887
171Progressive microcephaly (HP:0000253)1.61662533
172Abnormal rod and cone electroretinograms (HP:0008323)1.61635060

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.73555062
2VRK23.18977462
3CDC73.06267705
4EEF2K2.76898876
5TRIM282.71735319
6BMPR1B2.54904995
7ACVR1B2.34107145
8MAP4K22.32599634
9MKNK12.28278281
10KIT2.21217085
11TGFBR12.15311446
12PASK2.14843081
13WNK32.09699976
14NEK22.09308713
15BTK2.08826592
16WEE12.01837789
17FLT32.00632018
18CLK11.98832634
19TXK1.95859395
20MAP3K101.81187838
21NME21.77427981
22TAF11.70097623
23STK101.66462889
24JAK31.65379821
25TNIK1.64788352
26BLK1.63615396
27ZAP701.63514261
28SRPK11.56324734
29PLK21.56155725
30VRK11.53478470
31RPS6KB21.53451794
32ATR1.50145081
33TEC1.45969532
34DYRK31.43992543
35STK41.43055682
36INSRR1.41222146
37RPS6KA41.41020694
38CSF1R1.40825503
39MAPK131.34434783
40CDK71.31295096
41BRSK21.30680219
42GRK11.30320053
43PIM21.28353998
44TYK21.27434771
45BCR1.27032831
46LRRK21.26819687
47ADRBK21.21867440
48PIM11.21315211
49BUB11.21116922
50SYK1.18521482
51GRK61.16088216
52CDK121.15722270
53OXSR11.15329302
54SCYL21.13295712
55CSNK1G31.09537908
56AURKB1.06525288
57MAP3K81.02759689
58MKNK21.02253508
59CSNK1G11.01653199
60EIF2AK21.00869076
61CCNB11.00788404
62TAOK20.99978740
63CDK40.96203771
64BRD40.95873017
65STK390.95846750
66PLK40.94642356
67NLK0.93490881
68LYN0.93009720
69ITK0.92514103
70MAPKAPK50.92418573
71LCK0.92028773
72IRAK40.91923732
73CDK80.91515249
74FRK0.91204146
75TSSK60.90099842
76EIF2AK30.89489473
77NEK10.88799812
78PKN20.86938400
79CSNK1G20.86505389
80CSNK1A1L0.85868264
81CHUK0.85763904
82PLK10.84977135
83STK160.83845169
84CDK60.83605724
85PAK40.79948864
86SIK30.79310174
87TTK0.78493243
88TESK20.77517893
89TAOK30.76110911
90EIF2AK10.75939901
91MAPKAPK30.75882197
92TLK10.75026490
93YES10.74171251
94EPHA30.73865246
95HIPK20.72750711
96FGFR30.72087265
97CHEK10.71498601
98ATM0.70530638
99DYRK20.70506619
100ERBB30.69333952
101BRSK10.67672596
102MATK0.65871188
103MST40.65504629
104TNK20.64397980
105ZAK0.64363796
106KDR0.64347400
107BCKDK0.63523861
108TGFBR20.62890170
109FER0.62822741
110IKBKB0.61565064
111CHEK20.61363541
112IKBKE0.60888123
113CSK0.60639508
114FGFR20.58392559
115PAK30.55747406
116CDK90.55373584
117CDK20.53483735
118DYRK1B0.52677865
119PLK30.52642630
120MAP2K30.52573849
121RPS6KA60.51847143
122HCK0.50767093
123RPS6KC10.50663192
124RPS6KL10.50663192
125MAP3K140.50516724
126PBK0.48706320
127DAPK10.48322691
128MAPK110.47138713
129RPS6KA50.46954168
130NUAK10.46689457
131GRK50.44957986
132PDK20.44590780
133STK30.41113147
134MARK30.40477050
135PRKCI0.39080490
136PIK3CA0.38567500
137PRKCQ0.37916544
138ADRBK10.37026149
139PRKCE0.34746054
140PTK2B0.32953179
141MINK10.32431483
142ABL10.31451761
143* CSNK2A10.29482716
144CDK30.28955766
145CSNK1D0.27735136
146CSNK1A10.26159832
147FES0.26107981
148IGF1R0.25401693

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.79760385
2Mismatch repair_Homo sapiens_hsa034303.75986072
3Base excision repair_Homo sapiens_hsa034103.25163947
4Ribosome_Homo sapiens_hsa030102.87662621
5Spliceosome_Homo sapiens_hsa030402.81655081
6Homologous recombination_Homo sapiens_hsa034402.66348145
7Cell cycle_Homo sapiens_hsa041102.45558169
8Primary immunodeficiency_Homo sapiens_hsa053402.43873652
9Nucleotide excision repair_Homo sapiens_hsa034202.39756283
10Non-homologous end-joining_Homo sapiens_hsa034502.18639631
11Propanoate metabolism_Homo sapiens_hsa006402.00478447
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.95715358
13Fanconi anemia pathway_Homo sapiens_hsa034601.90826355
14RNA polymerase_Homo sapiens_hsa030201.88054807
15RNA transport_Homo sapiens_hsa030131.87013197
16Pyrimidine metabolism_Homo sapiens_hsa002401.85114537
17Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.70314007
18Herpes simplex infection_Homo sapiens_hsa051681.64182089
19Antigen processing and presentation_Homo sapiens_hsa046121.60088314
20mRNA surveillance pathway_Homo sapiens_hsa030151.59510055
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57592501
22RNA degradation_Homo sapiens_hsa030181.54765324
23p53 signaling pathway_Homo sapiens_hsa041151.52997076
24Phototransduction_Homo sapiens_hsa047441.49744114
25Selenocompound metabolism_Homo sapiens_hsa004501.46795800
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.42374478
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42026854
28B cell receptor signaling pathway_Homo sapiens_hsa046621.41871209
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.34422437
30Measles_Homo sapiens_hsa051621.33898562
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.33240871
32One carbon pool by folate_Homo sapiens_hsa006701.33184463
33Hematopoietic cell lineage_Homo sapiens_hsa046401.33040425
34Butanoate metabolism_Homo sapiens_hsa006501.28735052
35Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.26422459
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.25098045
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.24573078
38Basal transcription factors_Homo sapiens_hsa030221.23033731
39Oxidative phosphorylation_Homo sapiens_hsa001901.19772414
40Leishmaniasis_Homo sapiens_hsa051401.19770648
41Systemic lupus erythematosus_Homo sapiens_hsa053221.18883491
42Epstein-Barr virus infection_Homo sapiens_hsa051691.16550068
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16153970
44Viral carcinogenesis_Homo sapiens_hsa052031.16079256
45Fatty acid elongation_Homo sapiens_hsa000621.14890413
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.14718378
47Parkinsons disease_Homo sapiens_hsa050121.14686005
48Nitrogen metabolism_Homo sapiens_hsa009101.14295794
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.13529402
50Autoimmune thyroid disease_Homo sapiens_hsa053201.12329387
51Hepatitis B_Homo sapiens_hsa051611.06972539
52HTLV-I infection_Homo sapiens_hsa051661.04826696
53Graft-versus-host disease_Homo sapiens_hsa053321.04339351
54Chronic myeloid leukemia_Homo sapiens_hsa052201.02119008
55Small cell lung cancer_Homo sapiens_hsa052221.02002476
56Proteasome_Homo sapiens_hsa030501.01332998
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.99902448
58Linoleic acid metabolism_Homo sapiens_hsa005910.98501495
59T cell receptor signaling pathway_Homo sapiens_hsa046600.98442464
60Thyroid cancer_Homo sapiens_hsa052160.97787994
61Viral myocarditis_Homo sapiens_hsa054160.97671071
62Legionellosis_Homo sapiens_hsa051340.96425700
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.96027179
64Type I diabetes mellitus_Homo sapiens_hsa049400.95411714
65Acute myeloid leukemia_Homo sapiens_hsa052210.94864455
66Caffeine metabolism_Homo sapiens_hsa002320.94624208
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94220853
68Colorectal cancer_Homo sapiens_hsa052100.92620522
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92606517
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91082641
71Protein export_Homo sapiens_hsa030600.90084112
72N-Glycan biosynthesis_Homo sapiens_hsa005100.89462245
73Peroxisome_Homo sapiens_hsa041460.87952286
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87645477
75Shigellosis_Homo sapiens_hsa051310.86925378
76Purine metabolism_Homo sapiens_hsa002300.84740150
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84544575
78Tryptophan metabolism_Homo sapiens_hsa003800.84303298
79MicroRNAs in cancer_Homo sapiens_hsa052060.84036589
80Notch signaling pathway_Homo sapiens_hsa043300.83825973
81Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83011049
82Influenza A_Homo sapiens_hsa051640.82621459
83Ether lipid metabolism_Homo sapiens_hsa005650.82340883
84Osteoclast differentiation_Homo sapiens_hsa043800.82027319
85Toxoplasmosis_Homo sapiens_hsa051450.79873284
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.77872839
87* Apoptosis_Homo sapiens_hsa042100.76761405
88Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76423883
89Steroid biosynthesis_Homo sapiens_hsa001000.76162513
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75202339
91Non-small cell lung cancer_Homo sapiens_hsa052230.73814907
92Pancreatic cancer_Homo sapiens_hsa052120.71662179
93Other glycan degradation_Homo sapiens_hsa005110.69886818
94Platelet activation_Homo sapiens_hsa046110.65825468
95Huntingtons disease_Homo sapiens_hsa050160.64935878
96Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63688360
97Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63627162
98Pyruvate metabolism_Homo sapiens_hsa006200.62849543
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62540711
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.62174063
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60180557
102Alcoholism_Homo sapiens_hsa050340.57064338
103Allograft rejection_Homo sapiens_hsa053300.54876722
104Glutathione metabolism_Homo sapiens_hsa004800.54703971
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54463673
106Regulation of autophagy_Homo sapiens_hsa041400.54252072
107Pertussis_Homo sapiens_hsa051330.52568602
108Olfactory transduction_Homo sapiens_hsa047400.51661598
109Metabolic pathways_Homo sapiens_hsa011000.50937888
110Pathways in cancer_Homo sapiens_hsa052000.50013360
111Endometrial cancer_Homo sapiens_hsa052130.49870183
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49856336
113Chemokine signaling pathway_Homo sapiens_hsa040620.49443195
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49258465
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.47221676
116Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46245834
117Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46068200
118Fatty acid metabolism_Homo sapiens_hsa012120.45434067
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.44285455
120Chemical carcinogenesis_Homo sapiens_hsa052040.42968740
121Prostate cancer_Homo sapiens_hsa052150.41695004
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41154017
123Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40074382
124Asthma_Homo sapiens_hsa053100.38454790
125Alzheimers disease_Homo sapiens_hsa050100.38187927
126Lysine degradation_Homo sapiens_hsa003100.37917134
127TNF signaling pathway_Homo sapiens_hsa046680.37028142
128Drug metabolism - other enzymes_Homo sapiens_hsa009830.36329119
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36322898
130Oocyte meiosis_Homo sapiens_hsa041140.36267235
131Adherens junction_Homo sapiens_hsa045200.35485173
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.35358929
133Neurotrophin signaling pathway_Homo sapiens_hsa047220.34457217
134Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34079000
135Tuberculosis_Homo sapiens_hsa051520.33937464
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33022955
137Glycerolipid metabolism_Homo sapiens_hsa005610.32847459
138Arachidonic acid metabolism_Homo sapiens_hsa005900.32704214
139AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.32413347
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32347180
141Sulfur metabolism_Homo sapiens_hsa009200.31643723
142Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31378560
143Malaria_Homo sapiens_hsa051440.29838217
144Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.28764447
145Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28567586
146Hepatitis C_Homo sapiens_hsa051600.28534133
147Basal cell carcinoma_Homo sapiens_hsa052170.27947117
148Pentose phosphate pathway_Homo sapiens_hsa000300.27234810
149Taste transduction_Homo sapiens_hsa047420.27216508
150Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.27161687
151Retinol metabolism_Homo sapiens_hsa008300.24763544
152Fatty acid degradation_Homo sapiens_hsa000710.24360559
153Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19445097
154Vitamin B6 metabolism_Homo sapiens_hsa007500.18128903
155Rheumatoid arthritis_Homo sapiens_hsa053230.18002669
156Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.16160762

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